KR20170001661A - Reactant-conversion process at the liquid-liquid interface - Google Patents

Abstract

The present invention relates to a process for converting a reaction material on a liquid-liquid interface. More specifically, the present invention relates to a process for converting a reaction material on a liquid-liquid interface, which remarkably increases the yield of products as well as reaction efficiency by quickly carrying out a reaction taking place on the interface between two liquids under a favorable condition.

Description

Reactant-conversion process at the liquid-liquid interface {Reactant-conversion process at the liquid-liquid interface}

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a process for converting a reactant at a liquid-liquid interface, and more particularly, to a process for converting a reactant in a liquid- To a reaction process which can be improved.

Conventionally, a method of using a reaction in two unmixed liquids includes a method in which a reaction material is dispersed in each liquid phase that is not mixed so that a reaction occurs at the interface between two phases, and a method in which two reaction materials are dispersed in a liquid phase, And a method of selectively moving the liquid phase to another liquid phase.

Although the above methods use an enzyme or a catalytic material, there is a possibility that the materials for carrying out the catalytic reaction are spread evenly in one liquid rather than at the interface, and the efficiency of the reaction may be lowered. There is a problem that the amount of the catalyst located at the interface at which the reaction occurs is significantly decreased because the catalyst is floated in the upper part of the liquid located at the upper part or sinks to the lower part of the liquid located at the lower part. Further, the reaction occurring at the interface between the two liquids can be carried out more smoothly in a faster condition, thereby increasing the reaction efficiency and not significantly improving the yield of the reaction product. Further, any reaction mediated by the catalyst may be a reversible reaction. Even if the catalyst is converted into the product by the catalyst, when the time for separation of the product is delayed, the product is converted into the reaction product again to obtain the desired product There was no problem.

JP 1997-248585 A (published September 22, 1997)

SUMMARY OF THE INVENTION The present invention has been made in order to solve the problems as described above, and it is an object of the present invention to provide a method for introducing a structure capable of being positioned at the interface to place a reaction catalyst on a liquid- The present invention is to provide a reaction material conversion process which can significantly improve the conversion yield of reactants at the liquid-liquid interface by including a catalyst.

In order to solve the above-mentioned problems, the present invention provides a reaction process for performing a reaction under a structure floating on a liquid-liquid interface.

According to a preferred embodiment of the present invention, the structure comprises a reaction catalyst.

According to a preferred embodiment of the present invention, the first liquid, the second liquid and the structure may satisfy the following equation (1).

[Equation 1]

First liquid density <Structure average density <Second liquid density

According to a preferred embodiment of the present invention, the reactants in the first liquid and / or the reactants in the second liquid are capable of forming the product by the reaction catalyst in the structure, Or in the second liquid.

According to a preferred embodiment of the present invention, the first liquid and the second liquid are each independently water, isooctane, dichlorohexane, hexane, heptane, cyclohaxane, Diethylether, octane, ethyl acetate, dichloromethane, chloroform, carbon tetrachloride, toluene, tetrahydrofuran, tetrahydrofuran, And may include at least one solvent selected from the group consisting of acetone, pyridine, ethylene glycol, and butanediol.

According to a preferred embodiment of the present invention, there is provided a liquid container comprising a first liquid, a second liquid and a third liquid which are not mixed with each other, the second liquid forms an interface with the first liquid and the third liquid, 3 liquids are separated from each other, the structure comprising a first structure and a second structure, wherein the first structure is present at an interface formed between the first liquid and the second liquid, 3 liquid. &Lt; / RTI &gt;

According to a preferred embodiment of the present invention, the first liquid, the second liquid, the third liquid, the first structure and the second structure can satisfy the following Equation 2 and Equation 3.

[Equation 2]

First liquid density <First structure average density <Second liquid density

[Equation 3]

Second liquid density <second structure average density <third liquid density

According to a preferred embodiment of the present invention, each of the first structure and the second structure may comprise the same reaction catalyst or different reaction catalysts.

According to a preferred embodiment of the present invention, the reactants in the first liquid and / or the reactants in the second liquid form an intermediate by the reaction catalyst in the first structure, To form the final product.

According to one preferred embodiment of the present invention, as the reaction progresses, the concentration of the reactant in the first liquid becomes lower and the concentration of the final product in the third liquid increases.

According to a preferred embodiment of the present invention, the first liquid, the second liquid and the third liquid are each independently water, isooctane, dichlorohexane, hexane, heptane, Examples of the solvent include cyclohexane, diethylether, octane, ethyl acetate, dichloromethane, chloroform, carbon tetrachloride, toluene, tetrahydrofuran at least one liquid selected from the group consisting of tetrahydrofuran, acetone, pyridine, ethylene glycol, and butanediol.

According to a preferred embodiment of the present invention, the structure comprises a reaction catalyst; A body supporting the reaction catalyst; And a floating portion.

According to a preferred embodiment of the present invention, the floating portion is coupled to the body portion, causing the structure to float on the liquid-liquid interface.

According to a preferred embodiment of the present invention, there is provided a process for producing a catalyst according to claim 10, wherein at least one body part is laminated with at least one body part, and the reaction catalyst is adsorbed on the body part by ionic bonding, As shown in Fig.

According to a preferred embodiment of the present invention, the body portion is stacked with at least one body portion, the body portion includes a carrier, and the reaction catalyst may be fixed to the carrier.

According to a preferred embodiment of the present invention, the body portion may include a first body and a second body, and further includes a carrier between the first body and the second body, And may be fixed to the surface of the carrier.

According to a preferred embodiment of the present invention, the carrier is selected from the group consisting of polymer fibers, electrically conductive polymers, porous particles, spherical particles, nanoparticles, beads, carbon nanotubes, wires, pilas, graphene, Or more species.

According to a preferred embodiment of the present invention, the carrier may be bonded to the reaction catalyst by simple adsorption, ionic bonding and covalent bonding by a functional group, and the reaction catalyst may be fixed to the carrier.

According to a preferred embodiment of the present invention, the reaction catalyst may include at least one selected from an enzyme, an organic catalyst, and an inorganic catalyst.

According to a preferred embodiment of the present invention, the enzyme is selected from the group consisting of a carbonic anhydrase, trypsin, chymotrypsin, subtilisin, papain, sumolysin, lipase, peroxidase, tyrosinase, lacase, Wherein the enzyme is selected from the group consisting of lanase, lactase, organic phosphohydrolase, choline esterase, glucose oxidase, pyranose oxidase, formate dehydrogenase, aldehyde dehydrogenase, alcohol dehydrogenase, glucose dehydrogenase and glucose isomerase Or more of the above enzymes.

According to a preferred embodiment of the present invention, the inorganic catalyst is selected from the group consisting of platinum, platinum, rhodium, palladium, lead, iridium, rubidium, iron, nickel, zinc, cobalt, copper, manganese, titanium, ruthenium, silver, molybdenum, tungsten, And at least one inorganic catalyst selected from the group consisting of aluminum, iron, antimony, tin, bismuth, barium, osmium, nitrogen oxide, copper oxide, manganese oxide, titanium oxide, vanadium oxide and zinc oxide.

According to a preferred embodiment of the present invention, the enzyme may form aggregates of enzymes through a crosslinking agent.

According to a preferred embodiment of the present invention, the enzyme may form an aggregate of enzymes in which enzymes are integrated through a crosslinking agent and a quencher.

According to another preferred embodiment of the present invention, the crosslinking agent is selected from the group consisting of diisocyanate, dianhydride, diepoxide, dialdehyde, diimide, 1-ethyl- At least one crosslinking agent selected from the group consisting of bis (imidoesters), bis (succinimidyl esters), diacid chlorides, dopamine, compounds comprising a dopamine derived catechol group, zeniprin and ethylene glycol diglycidyl ether .

According to another preferred embodiment of the present invention, the quenching agent is selected from the group consisting of methanol, ethanol, 1-propanol, 2-propanol, butyl alcohol, acetone, polyethylene glycol, ammonium sulfate, sodium chloride, sodium sulfate, sodium phosphate, , Potassium sulfate, and potassium phosphate.

According to another preferred embodiment of the present invention, each of the first body and the second body may be a lattice-shaped planar structure, and each of the first body and the second body may have the reaction material, An opening can be formed.

According to another preferred embodiment of the present invention, the first body and the second body may be arranged in parallel with each other in the vertical direction.

According to another preferred embodiment of the present invention, the floating portion includes a first structure coupled to one end of the body portion and a second structure coupled to the other end portion of the body portion, wherein the first structure and the second structure The structure may move up and down in a state in which the body portion is immersed in the first liquid and the second liquid so as to float on the interface between the first liquid and the second liquid.

According to another preferred embodiment of the present invention, the first structure or the second structure may include a fluid storage portion in which a fluid may be stored, and may be connected to the first structure or the second structure And a pump for allowing the fluid to flow in and out of the fluid reservoir.

According to another preferred embodiment of the present invention, the fluid that flows into the fluid reservoir through the pump may be air or the first liquid and the second liquid.

According to another preferred embodiment of the present invention, the reactant may be contained in at least one liquid selected from the first liquid and the second liquid.

According to another preferred embodiment of the present invention, the floating portion has at least one void space in which the floating control material can be included, and the average density of the structure can be adjusted by adjusting the volume of the hollow voids.

According to another preferred embodiment of the present invention, the floating control material is at least one substance selected from the group consisting of air, nitrogen, oxygen, argon, carbon dioxide, neon, ozone, helium, methane, xenon, krypton, hydrogen .

According to another preferred embodiment of the present invention, the average density of the structure can be controlled by adjusting the material of the body portion and / or the floating portion.

(ABS), polycarbonate (PC), polyvinyl alcohol (PVA), polystyrene (PS), or the like may be used as the material of the body portion and / or the floating portion. According to another preferred embodiment of the present invention, , Polylactic acid, polycaprolactam, polycaprolactone, polylactic-co-glycolic acid, polyacrylonitrile, polyester, polyethylene, polyethyleneimine, polypropylene oxide, polyurethane, polyglycolic acid, polyethylene terephthalate, poly One selected from the group consisting of methyl methacrylate, polydimethylsiloxane, polystyrene-co-maleic anhydride, Teflon, collagen, nylon, cellulose, chitosan, glass, gold, silver, aluminum, iron, Or more.

Hereinafter, terms used in the present invention will be described.

As used herein, the terms "comprises" and "having" are used to specify that a feature, a number, a step, an operation, an element, a component, or a combination thereof is described in the specification, It is to be understood that the foregoing does not preclude the presence or addition of other features, numbers, steps, operations, elements, parts, or combinations thereof. Also, where a section such as a layer, a film, an area, a plate, or the like is referred to as being "on" another section, it includes not only the case where it is "directly on" another part but also the case where there is another part in between. On the contrary, where a section such as a layer, a film, an area, a plate, etc. is referred to as being "under" another section, this includes not only the case where the section is "directly underneath"

The process of converting the reactants at the liquid-liquid interface of the present invention carried out in the presence of the structure not only prevents conversion of the converted product into the reactant through the interfacial reaction between the liquid and the liquid, It is possible to remarkably improve the yield of the produced material and to separate the substance present in the specific liquid at a high concentration and / or recover it at a high concentration. It is also possible to synthesize the material through separation of the enantiomer and interfacial reaction.

1 is a schematic diagram illustrating a process for converting a reactant at a liquid-liquid interface according to one embodiment of the present invention.
2 is a perspective view illustrating a structure according to an embodiment of the present invention.
3 is an exploded perspective view of a structure according to an embodiment of the present invention.
FIG. 4 is a plan view showing a reaction catalyst bonded to a carrier of a structure according to an embodiment of the present invention. FIG.
5 is a cross-sectional view illustrating a floating portion of a structure according to an embodiment of the present invention.
6 is a cross-sectional view illustrating a first modification of the structure floating unit according to an embodiment of the present invention.
7 is a cross-sectional view showing a second modification of the structure floating unit according to an embodiment of the present invention.
8 is a cross-sectional view showing a third modification of the structure body floating unit according to an embodiment of the present invention.
FIGS. 9 to 11 are plan views showing a procedure for fabricating a structure according to an embodiment of the present invention.
Fig. 12 shows a real image of the structure prepared in Preparation Example 1. Fig.
13A to 13D are photographs of the measurement results of the degree of suspension of the structure according to Examples 1 to 4 of the present invention.
Fig. 14 is a photograph showing that the size of the air gap in the floating part of the structure is adjusted to adjust the degree of floating of the structure.
15 is a photograph and a conceptual view showing a reaction process of the structure according to the fifth embodiment of the present invention.
16 is a graph of the reaction result performed in Experimental Example 1. Fig.
Figure 17 is a schematic diagram of a preferred embodiment of the reactant conversion process of the present invention.

Hereinafter, the present invention will be described in more detail.

As described above, according to the conventional art, there is a problem that the efficiency of the reaction is lowered because the materials for carrying out the catalytic reaction spread evenly in one liquid. When two liquids form an interface and are located at the upper and lower sides, There is a problem in that the amount of the catalyst located at the interface at which the reaction occurs is significantly reduced because it floats in the upper layer portion or sinks to the lower layer portion of the liquid located in the lower portion.

Further, any reaction mediated by the catalyst may be a reversible reaction. Even if the reactant is converted into the product by the catalyst, if the time for the separation of the product is delayed, the product is converted again into the reactant, Can not be obtained.

Therefore, the present invention sought to solve the above-mentioned problems by performing the conversion of the reactants under the structure located at the liquid-liquid interface.

The reaction material conversion process of the present invention performs a reaction under a structure located at a liquid-liquid interface, and each of the liquids may contain a reaction material (or a solute) and a solution, or either liquid may contain only a solution .

In addition, the reactant may be a liquid (i.e., a solution) itself, in which case each of the liquids may become a reactant and cause a reaction to generate a new product at the interface of the liquid and the liquid or to decompose the reactant.

The first liquid and the second liquid may include a first liquid and a second liquid which are not mixed with each other, and the density of the first liquid and the second liquid and the structure may satisfy the following equation (1).

[Equation 1]

First liquid density <Structure density <Second liquid density

Referring to Figure 1, a structure is present at the interface formed between the first liquid 3 and the second liquid 5 (i.e., it floats in the first liquid), and the reactant and / The reactant material forms a product by the reaction catalyst in the structure. And, the formed product material is present in the first liquid and / or the second liquid, preferably in the second liquid.

In the present invention, the structure may include a reaction catalyst that catalyzes the reaction of the reactant. The reactant may be contained in at least one liquid selected from the first liquid and the second liquid.

In addition, the reactant may be a first liquid and a second liquid per se, in which case the first liquid and the second liquid become reactants respectively and a new product is produced at the interface of the first liquid and the second liquid It is possible to cause a reaction in which the reactant is decomposed. In addition, the reactant may be a first component and a second component, respectively, included in the first liquid and the second liquid, wherein the first component and the second component may react at the liquid interface.

The first liquid and the second liquid are each independently selected from the group consisting of water, isooctane, dichlorohexane, hexane, heptane, cyclohaxane, diethylether, the solvent may be selected from the group consisting of octane, ethyl acetate, dichloromethane, chloroform, carbon tetrachloride, toluene, tetrahydrofuran, acetone, pyridine, Ethylene glycol and butanediol, and preferably at least one selected from the group consisting of water, isooctane, 1,6-dichlorohexane, hexane, and heptane, and more preferably, it may include water and isooctane.

Taking the reactant material conversion as a specific example, assuming that the first liquid is water, the second liquid is iso-octene, and the first liquid contains alcohol and organic acid as the reactants, Can react with an ester compound by a lipase (reaction catalyst). When the ester compound as a resultant substance is continuously present in the first liquid, the reactant organic acid and alcohol There is a problem that the yield of the desired product material may be significantly lowered due to the reverse reaction. Accordingly, it is preferable that the product produced by the reaction of the reactant generated in the first liquid is separated from the first liquid as soon as possible. If the second liquid having a higher solubility than the first liquid is prepared for the product, The product material can be transferred from the first liquid to the second liquid and stored in the first liquid and / or the second liquid, preferably dissolved in the second liquid.

And, the product material present in the first liquid must quickly move to the second liquid before the reverse reaction to the reaction material occurs. If the first liquid portion at the interface between the first liquid as the reaction site and the second liquid as the mobile storage site If the reaction to the product material occurs, the product material can be transferred to the second liquid as quickly as possible. Therefore, if the reaction catalyst is present at the interface of two liquids, there is an advantage that the product material can be moved to and stored in the second liquid so that the yield of the desired product material can be remarkably increased.

Accordingly, the present invention can improve the reaction yield by applying the reaction catalyst in a structure that can float on the interface between the first liquid and the second liquid to perform the reaction.

Further, as shown in Figs. 15 (a) and 15 (b), the present invention is characterized in that a specific substance present in a specific liquid is selectively separated Or can be obtained at a high concentration.

More specifically, the reaction material conversion process of the present invention includes a first liquid, a second liquid, and a third liquid, wherein the second liquid forms an interface with the first liquid and the third liquid, Wherein the first liquid and the third liquid are separated from each other and the structure includes a first structure and a second structure, the first structure being present at an interface formed between the first liquid and the second liquid, 2 &lt; / RTI &gt; liquid and the third liquid.

Here, the first liquid, the second liquid, the third liquid, the first structure, and the second structure may satisfy Equation 2 and Equation 3 below.

[Equation 2]

First liquid density <First structure density <Second liquid density

[Equation 3]

Second liquid density < Second structure density < Third liquid density

The first liquid, the second liquid and the third liquid are each independently selected from the group consisting of water, isooctane, dichlorohexane, hexane, heptane, cyclohexane, diethyl But are not limited to, diethylether, octane, ethyl acetate, dichloromethane, chloroform, carbon tetrachloride, toluene, tetrahydrofuran, acetone, , Pyridine, ethylene glycol, and butanediol. The solvent may be at least one solvent selected from the group consisting of pyridine, pyridine, ethylene glycol, and butanediol.

In addition, each of the first structure and the second structure may include the same reaction catalyst or different reaction catalysts.

As shown in FIG. 15 (b), the reactant in the first liquid and the reactant in the second liquid form an intermediate by the reaction catalyst in the first structure, and the intermediate is the first liquid and / Is present in the liquid, preferably at a higher concentration in the second liquid than in the first liquid, and the intermediate forms the final product by the reaction catalyst in the second structure. That is, as the reaction material conversion step proceeds, the concentration of the reactant in the first liquid becomes lower and the concentration of the final product in the third liquid increases. 15 (b)), it is possible to move and separate a specific substance from the first liquid (A in Fig. 15 (b)) to the second liquid (in Fig. 15 (b)

In addition, the reactants in the first liquid and the final product in the third liquid may be the same or different materials as described above, depending on the type of reactants in the second liquid and the type of reaction catalyst in the second structure .

15 (b), the first liquid is a liquid in which 2-phenoxypropionic acid including both the (R) phase and the (S) phase is dissolved in water as a solvent, and the third liquid The liquid includes only water, and the second liquid is a liquid dissolved in butyl alcohol in iso-octane as a solvent, and the first liquid and the third liquid are separated by the diaphragm. The second liquid forms an interface between the first liquid and the third liquid.

The first structure including the reaction catalyst floats on the interface between the first liquid and the second liquid, the second structure including the reaction catalyst floats on the interface between the second liquid and the third liquid, Upon initiation of the reaction, 2-phenoxypropionic acid containing both the (R) phase and the (S) phase in the first liquid reacts with the butyl alcohol in the second liquid to form butyl-2-phenoxypropanoate 2-phenoxypropanoate) is formed from the product, which is present in the second liquid. At this time, the reaction rate is increased by the reaction catalyst in the first structure and the yield of butyl-2-phenoxypropanoate is increased. The butyl-2-phenoxypropanoate of the second liquid reacts with the reaction catalyst of the second structure at the interface with the second liquid to form butyl alcohol and 2-phenoxypropionic acid on the (R) 2-phenoxypropionic acid on (R) is dissolved in the second liquid. That is, the 2-phenoxypropionic acid which is present in the first liquid but not in the second liquid before the start of the reaction moves from the first liquid to the second liquid as the reaction proceeds, and the 2-phenoxypropionic acid 1 liquid and can be obtained at a high concentration. Alternatively, the compound (S) is obtained by converting the (S) phase compound into the (R) phase compound or selectively separating only the (R) phase or the (S) phase from the compound containing both the (R) phase and the You can do it.

When a plurality of substances are present in a liquid through such a method, a specific substance can be separated from the liquid and obtained at a high concentration.

In addition, as shown in the schematic view of FIG. 17, the reaction material conversion process at the liquid-liquid interface of the present invention includes a first liquid and a third liquid separated from each other in a lower portion of the reaction tank, Liquid is present and can be carried out under process conditions in which the structure is present at the interface of the first liquid and the third liquid, the interface of the third liquid and the second liquid, and the second liquid and the fourth liquid interface, respectively.

At this time, the first liquid and the second liquid are denser than the third liquid, and the second liquid is denser than the fourth liquid. However, the first liquid not directly contacting does not necessarily have to be lower in density than the fourth liquid.

In addition, each of the structures (first to third structures) existing at the interfaces may include different kinds of reaction catalysts.

Specifically, A, which is a reaction material in the first liquid, reacts with B of the third liquid by the reaction catalyst of the first structure to form a C-generating material, and then the C- The A-producing material or the D-producing material, which is a product material, is formed in the second liquid by the reaction catalyst. Next, the A-producing material or the D-producing material, which is the second liquid producing material, reacts with the E-reactive material of the fourth liquid by the reaction catalyst of the third structure to form the F-producing material.

The reaction catalysts in the first to third structures may be the same as each other, or may include other reaction catalysts.

As described above, the reaction material conversion process at the liquid-liquid interface of the present invention can change the reaction process while changing the kind of the liquid and the kind of the reaction catalyst.

Hereinafter, the structure including the reaction catalyst used in the reaction material conversion process at the liquid-liquid interface of the present invention will be described in detail. Hereinafter, a structure (or a structure) according to an embodiment of the present invention will be described in more detail with reference to the drawings, but the present invention can be implemented in various different forms and is not limited to the embodiments described herein. In the drawings, the same or similar elements are denoted by the same reference numerals throughout the specification.

The structure comprises a reaction catalyst; A body supporting the reaction catalyst; And at least one floating part coupled to the body part and allowing the body part to float on the liquid-liquid interface.

FIG. 1 is a schematic view illustrating a process of converting a reactant at a liquid-liquid interface according to an embodiment of the present invention. Referring to FIG. 1, The process (1) may include the water tank (7) and the structure (2).

Meanwhile, in an embodiment of the present invention, the water tank 7 can receive the first liquid and the second liquid therein. At this time, in one embodiment of the present invention, the two liquids include a first liquid (3) and a second liquid (5) that do not interact, the second liquid may be located on the first liquid, The liquid may be located on the second liquid, but is not limited thereto.

The structure 2 according to an embodiment of the present invention can support the reaction catalyst 60 and can float on the interface of the first liquid 3 and the second liquid 5. [ At this time, the reaction catalyst 60 may be formed to react with a reactant (not shown) present in any one of the first liquid 3 and the second liquid 5.

The liquid in which the structure 2 according to one embodiment of the present invention floats may be water containing an organic acid (reactant).

Referring to FIG. 1, an organic acid present in water as a reaction material may react with a reaction catalyst 60 supported on the body portion 10 of the structure 2 to become an ester.

1, the structure 2 according to an embodiment of the present invention can be formed by removing any substance present in the first liquid by the reaction catalyst 60 or by removing the reacting substance from the product material . &Lt; / RTI &gt;

In the present invention, the structure may be formed in a structure in which the material itself differs in density from the liquid, or is floating in the structure.

Referring to FIG. 2, the structure 2 according to an embodiment of the present invention may include a body portion 10 and a floating portion 30. The structure 2 according to an embodiment of the present invention can support the reaction catalyst 60 including the body portion 10 and can protect the reaction catalyst for a long period of time against changes in the external environment.

In addition, the structure 2 according to an embodiment of the present invention includes the floating portion 30 so that the body portion 10 can float on the interface between the first liquid and the second liquid.

In addition, the reaction catalyst (60) is contained in any one of the first liquid and the second liquid, the first liquid and the second liquid, and the other liquid or the first liquid not containing the reactant The first material and the second liquid.

Referring to FIG. 3, the body 10 may include a first body 11 and a second body 21 in one embodiment of the present invention. At this time, the reaction catalyst 60 is positioned between the first body 11 and the second body 21 so that the reaction catalyst can be supported between the first body and the second body.

In an embodiment of the present invention, the first and second bodies 11 and 21 may be made of acrylonitrile-butadiene-styrene (ABS), polycarbonate (PC), polyvinyl alcohol (PVA), polystyrene (PS) , Polylactic acid, polycaprolactam, polycaprolactone, polylactic-co-glycolic acid, polyacrylonitrile, polyester, polyethylene, polyethyleneimine, polypropylene oxide, polyurethane, polyglycolic acid, polyethylene terephthalate, poly One or more members selected from the group consisting of methyl methacrylate, polydimethylsiloxane, polystyrene-co-maleic anhydride, teflon, collagen, nylon, cellulose, chitosan, glass, gold, silver, aluminum, iron, &Lt; / RTI &gt;

Meanwhile, in the embodiment of the present invention, the first body 11 and the second body 21 may be in the form of a polygonal, circular, or elliptical shape such as a square, a rhombus, or a hexagon, It does not. In addition, the first body 11 and the second body may have openings 13 and 23 formed therein so that the reactive material can approach from the outside to the inside.

Referring to FIG. 3, the first body 11 and the second body 21 are arranged in parallel to each other in the vertical direction, and each may be a planar structure in the form of a lattice. Also, it may have a third body, a fourth body, and a fifth body that are the same or similar to the first body, the second body, and the like.

Meanwhile, in an embodiment of the present invention, the second body 21 may be disposed adjacent to the surface of the first liquid 3. [ That is, for example, the second body 21 may be immersed in the first liquid 3 or floated on the first liquid 3 in contact with the first liquid 3.

In an embodiment of the present invention, the first body 11 and the second body 21 are separated into a single structure and are arranged in parallel with each other, but the present invention is not limited thereto and the first body and the second body may be integrally formed.

In an embodiment of the present invention, protrusions 15 and 25 may be formed at both ends of the body 10 to be coupled to the floating unit 30. [ However, the protrusions 15 and 25 of the body 10 may be inserted into the coupling grooves 33a and 37b of the floating portion 30, but the present invention is not limited thereto.

In addition, the body may have three or more body parts, and each reaction body may be provided with a different reaction catalyst, and the degree of floating of the structure may be controlled to perform the reaction material conversion. For example, the A reaction catalyst is applied to the first body, the B reaction catalyst is applied to the second body, and the C reaction catalyst is applied to the third body, the A reaction catalyst is present only in the first liquid, The second liquid interface, and the C-reactive catalyst may be present only in the second liquid.

FIG. 4 is a plan view showing a reaction catalyst fixed to a carrier of a structure according to an embodiment of the present invention. FIG.

4, in an embodiment of the present invention, the carrier 50 is positioned between the first body 11 and the second body 21, and the reaction catalyst 60 is disposed between the first body 11 and the second body 21 To be fixed.

At this time, the reaction catalyst 60 may be bonded to the surface of the carrier 50 and fixed. In one embodiment of the present invention, the carrier 50 may be a nanostructure, but is not limited thereto.

In one embodiment of the present invention, the carrier may comprise at least one selected from polymer fibers, electrically conductive polymers, porous particles, spherical particles, nanoparticles, beads, carbon nanotubes, wires, filaments, graphene, And may include at least one carrier selected from the group consisting of polymer fibers, porous particles, carbon nanotubes, graphene and fullerenes.

Meanwhile, in one embodiment of the present invention, the polymer fiber may be selected from the group consisting of polyvinyl alcohol, polyacrylonitrile, nylon, polyester, polyurethane, polyvinyl chloride, polystyrene, cellulose, chitosan, polylactic acid, Polyglycolic acid, polyglycolic acid, polycaprolactone, collagen, polypyrrole, polyaniline and poly (styrene-co-maleic anhydride), preferably chitosan, polylactic acid, polylactic- And at least one polymer fiber selected from the group consisting of glycolic acid polycaprolactone, collagen, polypyrrole, polyaniline and poly (styrene-co-maleic anhydride), and the polymer fiber is modified to form a functional group Polymeric fiber having a functional group.

In addition, the carrier may be a polymer matrix in which the polymer fiber aggregate including a plurality of polymer fibers including a functional group forms a three-dimensional network structure. In addition, the polymer matrix may include a plurality of fiber pillars formed by protruding a part of the polymer fibers of the polymer fiber aggregate out of the surface of the polymer matrix.

Then, the functional group and the reaction catalyst may be coupled to each other to fix the reaction catalyst to the support. At this time, depending on the reaction catalyst, the functional group to be reacted varies, so that the functional group can be specified depending on the reaction catalyst.

Meanwhile, in one embodiment of the present invention, the reaction catalyst may be adsorbed and fixed on the carrier, but is not limited thereto.

Referring to FIG. 2, the floating unit 30 may include a first structure 31 and a second structure 35 coupled to the body 10 in an embodiment of the present invention.

Referring to FIG. 3, the first structure 31 may be coupled to the left end of the body 10, and the second structure 35 may be coupled to the other end of the body, It can be coupled to the right end.

5 to 8, in one embodiment of the present invention, the first structure 31 and the second structure 35 have a rectangular parallelepiped shape and a fluid storage portion S, which is a space in which a fluid can be stored, .

6 to 8, a structure 2 according to an embodiment of the present invention is configured to be suspended in two liquids so as to float on the interface between the first liquid 3 and the second liquid 5, Lt; / RTI &gt;

6 to 8, in one embodiment of the present invention, the first structure 31 and the second structure 35 are arranged in such a manner that the amount of the air and the liquid 3, 5 present in the fluid reservoir S It affects the buoyancy, so adjust the buoyancy by adjusting it.

In this case, since the fluid storage portion S of the first structure 31 and the second structure 35 is a space in which the air and the liquid 3, 5 are stored, the first structure and the second structure are increased in volume It can be made of a material which does not cause a reducing deformation.

In one embodiment of the present invention, the buoyancy control may be more complicated because the change in buoyancy of the first structure 31 and the second structure 35 must be taken into consideration when the volume of the first structure 31 and the second structure 35 changes.

That is, in one embodiment of the present invention, the first structure 31 and the second structure 35 are made of acrylonitrile-butadiene-styrene (ABS), polycarbonate (PC), polyvinyl alcohol (PVA), polystyrene ), Polylactic acid, polycaprolactam, polycaprolactone, polylactic-co-glycolic acid, polyacrylonitrile, polyester, polyethylene, polyethyleneimine, polypropylene oxide, polyurethane, polyglycolic acid, polyethylene terephthalate, One selected from the group consisting of polymethylmethacrylate, polydimethylsiloxane, polystyrene-co-maleic anhydride, teflon, collagen, nylon, cellulose, chitosan, glass, gold, silver, aluminum, iron, Or more.

Referring to FIG. 6, a first valve 39, a first pump 41, a second valve 43, and an air tank 45 may be disposed in the first structure 31.

At this time, as shown in FIG. 6, inlet ports 31a and 35a are formed on the side surfaces of the first structure 31 and the second structure 35 so that fluid can flow into the left and lower ends of the first structure and the second structure And the discharge ports 31b and 35b are formed in the right lower end so that the fluid can be discharged.

In one embodiment of the present invention, the first structure 31 and the second structure 35 are fluid (air or liquid) present in the fluid reservoir S through the inlets 31a and 35a and the outlets 31b and 35b. (3, 5)).

The first valve 39 and the third valve 46 are installed in the first structure 31 and the second structure 35 respectively and the first valve 39 and the third valve 46 are connected to the inlet ports 31a and 35a, And controls the flow path for flowing the fluid into the interior of the second structure.

Referring to FIG. 6, when the first valve 39 is opened, the first liquid 3 and the second liquid 5 outside the first structure 31 flow into the interior. Thus, the structure 2 according to an embodiment of the present invention can move downward by reducing buoyancy.

The second valve 43 and the fourth valve 49 are installed inside the first structure 31 and the second structure 35 and one end is connected to the discharge ports 31b and 35b, And controls the flow path for discharging the fluid to the outside of the second structure.

The other end of the second valve 43 and the fourth valve 49 are respectively connected to the first pump 41 and the second pump 47 so that the first structure 31 and the second The first liquid 3 and the second liquid 5 which are the fluids inside the structure 35 are moved to the outside.

Referring to FIG. 6, when the first pump 41 operates to send fluid, the first liquid 35 and the second liquid 5, which are the fluid inside the first structure 31, So that the amount of fluid inside the first structure is reduced and the buoyant force of the first structure is increased.

At this time, the first pump 41 is a pump for discharging the fluid in one direction. However, the present invention is not limited to this, and the pump may be a pump for causing the fluid to flow in both directions. If the first pump 41 is a bi-directional pump, the first pump can be operated to allow fluid to flow through the first valve 39.

Referring to FIG. 6, when the fluid is discharged by the first pump 41, the air tank 45 separates the air from the first structure 31 by the amount of the first liquid 3 and the second liquid 5, Thereby increasing the buoyancy of the first structure.

At this time, the air tank 45 may be an air cylinder tank and may be filled with compressed air. Further, the air tank 45 is effective for adjusting the buoyancy when the first structure 31 is in a position where air can not be obtained from the atmosphere.

Referring to FIG. 7, in an embodiment of the present invention, a fluid is present in the first structure 31, and a first pump 41 is provided outside the first structure to form one end of the first structure, for example, 1 &lt; / RTI &gt; structure.

In this case, the first pump 41 may be a one-directional pump or a two-way pump, and the buoyant force may be adjusted by introducing or discharging air or liquid 3, 5, which is fluid, into the first structure 31.

Referring to FIG. 8, a first valve 39, a first pump 41, a second valve 43, and an air tank 45 may be disposed in the first structure 31. 8, outlets 31b and 35b are formed on the side surfaces of the first structure 31 and the second structure 35 so as to discharge the fluid to the lower right end of the first structure and the second structure, as shown in FIG. do.

The first valve 39 and the third valve 46 are installed in the first structure 31 and the second structure 35 respectively and the first valve 39 and the third valve 46 are connected to the air tank 45, 2 Controls the opening and closing of the flow path for introducing the fluid into the inside of the structure.

In one embodiment of the present invention, when the first valve 39 is opened, the compressed air in the air tank 45 of the first structure 31 flows into the fluid reservoir S of the first structure. Thus, the structure 2 according to an embodiment of the present invention can move downward by reducing buoyancy.

The other end of the second valve 43 is connected to the first pump 41 to move the air, which is the fluid inside the first structure 31, to the outside by the pump dispensing operation.

Referring to FIG. 8, when the first pump 41 operates to send fluid, the air inside the first structure 31 can be discharged to the outside through the second valve 43.

As a result, the amount of air in the first structure decreases and the buoyant force of the first structure increases, so that the structure 2 according to an embodiment of the present invention can move upward.

The operation principle of the first structure 31 is the same as that of the third valve 46, the second pump 47 and the fourth valve 49 of the second structure 35 and will not be described below.

Referring to FIG. 2, protrusions 33 and 37 may be formed in a rectangular parallelepiped shape in the first structure 31 and the second structure 35, respectively, in an embodiment of the present invention.

The protrusions 33 and 37 may be formed on one side where the first structure 31 is coupled to the body 10 or on the left side where the second structure 35 is coupled to the body 10 have.

2, the protrusions 33 and 37 may be formed with coupling grooves 33a and 37b into which the protrusions 15 and 25 of the body 10 are inserted and fitted. At this time, the coupling grooves 33a and 37b may be formed so as to correspond to the protrusions so as to be fitted to the protrusions 15 and 25. [

FIGS. 9 to 11 are plan views illustrating a procedure for fabricating a structure according to an embodiment of the present invention. The structure 2 according to an embodiment of the present invention can be manufactured by 3D printing.

11, a carrier 50 coupled with an enzyme is coupled to the upper surface of the second body 21, and the reaction catalyst 60 is coupled between the first body and the second body by covering the first body 11 .

The protrusions 15 and 25 of the first body 11 and the second body 21 are formed in the first structure 31 and the second structure 35 formed in 3D printing by the engagement grooves 33a and 37b ).

The structure 2 according to an embodiment of the present invention includes the first structure 31 and the second structure 35 and is capable of absorbing buoyancy in a state of being immersed in the first liquid 3 and the second liquid 5. [ It is possible to make it float on the interface between the first liquid and the second liquid by adjusting.

In this case, in one embodiment of the present invention, the buoyant force can be controlled by adjusting the amount of air present in the fluid reservoir of the first structure 1 or adjusting the volume of the fluid reservoir, The buoyant force may be adjusted by adjusting the amounts of the first liquid 3 and the second liquid 5.

Accordingly, the structure (2) according to an embodiment of the present invention can be used for the separation of substances in the mixture, separation of an enantiomer and / or synthesis of an ingredient through an interfacial reaction through a catalytic reaction by a reaction catalyst bonded to the carrier (50) Can be used.

According to a preferred embodiment of the present invention, the reaction catalyst in the structure may include at least one selected from the group consisting of an enzyme as an organic catalyst and an inorganic catalyst, and the organic catalyst may be selected from the group consisting of carbonic anhydrase, trypsin, chymotrypsin, The present invention also relates to a method for producing dehydrogenase, which comprises administering to a mammal an effective amount of at least one compound selected from the group consisting of dexamethasone, dexamethasone, dexamethasone, dexamethasone, dexamethasone, dexamethasone, An enzyme, an aldehyde dehydrogenase, an alcohol dehydrogenase, a glucose dehydrogenase, and a glucose isomerization enzyme.

According to a preferred embodiment of the present invention, the inorganic catalyst is selected from the group consisting of platinum, platinum, rhodium, palladium, lead, iridium, rubidium, iron, nickel, zinc, cobalt, copper, manganese, titanium, ruthenium, silver, molybdenum, tungsten, And at least one inorganic catalyst selected from the group consisting of aluminum, iron, antimony, tin, bismuth, barium, osmium, nitrogen oxide, copper oxide, manganese oxide, titanium oxide, vanadium oxide and zinc oxide.

The enzyme may form an enzyme aggregate through crosslinking between enzymes using a crosslinking agent.

The crosslinking agent may be selected from the group consisting of diisocyanate, dianhydride, diepoxide, dialdehyde, diimide, 1-ethyl-3-dimethylaminopropylcarbodiimide, glutaraldehyde, bis (imidoesters) A compound containing diacid chloride, a dopamine, a compound containing a dapamine-derived catechol group, a zeniphine, and an ethylene glycol diglycidyl ether. Preferably, the crosslinking agent is a diisocyanate, One or more cross-linking agents selected from the group consisting of dianhydride, diepoxide, dialdehyde, diimide, 1-ethyl-3-dimethylaminopropyl carbodiimide, glutaraldehyde and glutaraldehyde.

The enzyme may be an enzyme aggregate formed by cross-linking enzymes using a cross-linking agent after precipitating an enzyme using a precipitating agent.

At this time, the quenching agent may be selected from the group consisting of methanol, ethanol, 1-propanol, 2-propanol, butyl alcohol, acetone, polyethylene glycol, ammonium sulfate, sodium chloride, sodium sulfate, sodium phosphate, potassium chloride, potassium sulfate, May be used alone or in combination, and preferably one or more quartz agents selected from the group consisting of methanol, ethanol, 1-propanol, 2-propanol, butyl alcohol, acetone, polyethylene glycol and ammonium sulfate.

Hereinafter, the present invention will be described with reference to the following examples. The following examples are provided to illustrate the invention, but the scope of the present invention is not limited by the following examples.

[ Example ]

Preparation Example  1: Fabrication of the structure

The two floating portions and the three body portions were made of the ABS (Acrylonitrile Butadiene Styrene) polymer in the form as shown in FIG. 3, and then assembled to form a structure composed of the three-layer body portion and the floating portion . At this time, the floating portion of the structure is hollow. The body portion is obtained by immobilizing 10 mg of lipase in 1 mg of a polymer nanofiber made of PS-PSMA (Polystyrene-Poly (styrene-co-maleic anhydride)) per one body part as a floating part and a reaction catalyst before assembly.

12 (a) and 12 (b) are photographs of a structure in which the floating part and the body part are assembled in a state in which the reaction catalyst is not immobilized.

FIG. 12 (c) shows a photograph of the structure after applying the reaction catalyst in water.

Preparation Example  2: Fabrication of structure

A structure was prepared in the same manner as in Preparation Example 1 except that a floating portion having a smaller vacancy than the vacant space in the floating portion of Preparation Example 1 was used.

Preparation Example  3: Fabrication of the structure

A structure was prepared in the same manner as in Preparation Example 1 except that a floating portion having larger vacancies than the vacant voids in the floating portion of Preparation Example 1 was used.

Example  One

As the first solvent, water was prepared by mixing blue dye (acid blue). Then, hexane was prepared as a second solvent.

Next, the first solvent was put in an empty bottle, and then the structure of Preparation Example 1 was added. Next, the second solvent was injected to confirm the floating degree of the structure, and the photograph is shown in FIG. 13 (a).

Example  2

As the first solvent, water was prepared by mixing blue dye (acid blue). Then, isooctane was prepared as a second solvent.

Next, the first solvent was put in an empty bottle, and then the structure of Preparation Example 1 was added. Next, the second solvent was injected to confirm the floating degree of the structure, and the photograph is shown in FIG. 13 (b).

Example  3

As the first solvent, water was prepared by mixing blue dye (acid blue). Then, diethyl ether was prepared as a second solvent.

Next, the first solvent was put in an empty bottle, and then the structure of Preparation Example 1 was added. Next, the second solvent was injected to confirm the floating degree of the structure, and the photograph is shown in FIG. 13 (c).

Example  4

As the first solvent, water was prepared by mixing blue dye (acid blue). Cyclohexane was prepared as a second solvent.

Next, the first solvent was put in an empty bottle, and then the structure of Preparation Example 1 was added. Next, the second solvent was injected to confirm the floating degree of the structure, and the photograph is shown in FIG. 13 (d)

Comparative Example  One

The same procedure as in Example 2 was carried out except that only the structure was suspended on the interface between the first solvent and the second solvent without applying the reaction catalyst to the structure.

Experimental Example  1: Evaluation of structure flotation depending on solution

13 (a) to 13 (d) show the photographs of Examples 1 to 4, respectively. It can be confirmed that the degree of floating of the structure relative to the first liquid differs depending on the type of the solution of the first solvent .

It can be confirmed that the structures of Examples 1 to 4 have the same average density, and the density of the second liquid is different from each other.

Experimental Example  2: Reaction experiment

The experiment was evaluated for the material conversion reaction under the first and second liquids of Example 2 and Comparative Example 1 above.

As the first liquid, 2-phenoxypropionic acid was dissolved in water as a solvent to prepare a 10 mM aqueous solution of 2-phenoxypropionic acid.

As the second liquid, a solution prepared by dissolving butyl alcohol in isooctane at a concentration of 1 M was prepared.

Next, in Example 2, the structure of Example 1 was floated at the interface between the first solvent and the second solvent, and the structure of Comparative Example 1 was not applied to the reaction catalyst, and the reaction was allowed to proceed, The concentration of 2-phenoxypropanoate (2-phenoxypropanoate) was measured and the results are shown in FIG.

As shown in FIG. 16, in the case of Comparative Example 1, there is almost no change in the concentration of the produced material after about 4 hours, whereas in the case of Example 2, the concentration of the produced material continuously increases with time .

Experimental Example  3: Floating portion  Measurement of structure float according to internal pore size

As the first solvent, water was prepared by mixing blue dye (acid blue). Then, isooctane was prepared as a second solvent.

Next, three bottles were prepared by injecting the first solvent into the empty bottle. Each of the following three bottles was filled with each of the structures prepared in Preparation Examples 1 to 3.

Next, the second solvent was injected to confirm the floating degree of the structure, and the photograph is shown in FIG.

Referring to FIG. 14, it can be seen that the floating degree of the structure is different according to the pore size in the floating portion of the structure, and it is confirmed that the degree of floating of the structure can be controlled through controlling the average density of the structure.

Example  5

As the first liquid, 2-phenoxypropionic acid was dissolved in water as a solvent to prepare a 10 mM aqueous solution of 2-phenoxypropionic acid.

As the second liquid, a solution in which butyl alcohol was dissolved in isooctane at a concentration of 1 M was prepared.

As the third liquid, only water was prepared.

Next, the first liquid and the third liquid were poured into the reactor provided with the diaphragm, respectively, and then the structure of Preparation Example 1 was placed in the first liquid, and the structure of Preparation Example 1 was placed in the third liquid.

Next, the second liquid is poured, and the baffle is installed on the second liquid side so that the product produced in the first liquid and the second liquid interface dissolves well in the second liquid, and the structure of the second liquid and the third liquid interface It was installed so that a good reaction with the reaction catalyst was performed. Further, a magnetic stirrer was installed at the bottom of the reactor, and a magnetic bar was charged into the first liquid and the third liquid.

In the reaction, the stirring speed of the second liquid was 75 rpm, the first liquid and the third liquid were stirred at 150 rpm, and the reaction temperature was 24 to 25 ° C.

The reaction was initiated under the above conditions, and the concentration of 2-phenoxypropionic acid in the first liquid and the second liquid was measured over time, and the results are shown in Table 1 below.

division The first liquid Third liquid Reaction time Concentration of 2-phenoxypropionic acid (mM) Concentration of 2-phenoxypropionic acid (mM) 0 hours 10 0 12 hours 6.7 0.51 24 hours 6.1 0.80 36 hours 5.9 0.83 48 hours 5.8 0.87

From the results of the experiment in Table 1, it was confirmed that 2-phenoxypropionic acid, which is the reactant of the first liquid, migrates to the third liquid, and the product is formed at a high reaction rate between the first liquid and the second liquid , And it was confirmed that the reaction was performed at a high reaction rate even between the second liquid and the third liquid.

1: liquid-liquid interfacial reactant conversion process
2: Structure 3: First liquid
5: second liquid 7: water tank
10: Body part 11: First body
13, 23: opening 15, 25:
21: second body 30: floating part
31: first structure 33, 37:
33a, 37a: coupling groove 35: second structure
39: first valve 41: first pump
43: second valve 45: air tank
46: third valve 47: second pump
49: fourth valve 50: carrier
60: Reaction catalyst

Claims (25)

The structure is placed at the liquid-liquid interface,
Characterized in that the structure comprises a reaction catalyst.
Reactant conversion process at liquid - liquid interface.
2. The method of claim 1, wherein the first liquid, the second liquid,
A reaction material conversion step at a liquid-liquid interface characterized by satisfying the following equation 1;
[Equation 1]
First liquid density <Structure average density <Second liquid density
3. The method according to claim 2, wherein at least one of the first liquid and the second liquid comprises a reactive material,
Wherein the reactant forms a product by catalysis on a reaction catalyst contained in the structure.
3. The method of claim 2, wherein the first and second liquids are each independently selected from the group consisting of water, isooctane, dichlorohexane, hexane, heptane, cyclohexane, diethyl But are not limited to, diethylether, octane, ethyl acetate, dichloromethane, chloroform, carbon tetrachloride, toluene, tetrahydrofuran, acetone, , Pyridine, ethylene glycol, and butanediol. A process for the conversion of a reactant at a liquid-liquid interface.
2. The method according to claim 1, wherein the first liquid, the second liquid, the third liquid and the first structure and the second structure,
The third liquid forms an interface with the first liquid and the second liquid, wherein the first liquid and the second liquid are separated from each other,
The structure includes a first structure and a second structure, wherein the first structure is present at the interface formed between the first liquid and the third liquid, and the second structure is present at the interface formed between the second liquid and the third liquid Wherein the reactant material is a liquid material.
6. The process according to claim 5, wherein the first liquid, the second liquid, the third liquid, the first structure and the second structure satisfy the following Equation 2 and Equation 3: ;
[Equation 2]
First liquid density <First structure average density <Third liquid density
[Equation 3]
Second liquid density <second structure average density <third liquid density
6. The process of claim 5, wherein each of the first and second structures comprises the same reaction catalyst or different reaction catalysts.
6. The method of claim 5, wherein the first liquid comprises a reactive material,
The reaction material forms an intermediate in the third liquid by the reaction catalyst included in the first structure,
Wherein the intermediate material forms a final product in a third liquid by a reaction catalyst included in the second structure.
6. The method of claim 5, wherein the first liquid, the second liquid and the third liquid are each independently water, isooctane, dichlorohexane, hexane, heptane, cyclohaxane, Diethylether, octane, ethyl acetate, dichloromethane, chloroform, carbon tetrachloride, toluene, tetrahydrofuran, tetrahydrofuran, Wherein at least one selected from the group consisting of acetone, pyridine, ethylene glycol and butanediol is contained in the reaction liquid at the liquid-liquid interface.
2. The method of claim 1,
A reaction catalyst;
A body portion including the reaction catalyst; And
And a floating portion for allowing the structure to be positioned at the liquid-liquid interface by engagement with the body portion.
[10] The apparatus of claim 10, wherein the body portion is stacked with at least one body portion,
Wherein the reaction catalyst is fixed to the reaction catalyst by adsorption, ionic bonding, covalent bonding or an adhesive material to the body part.
[10] The apparatus of claim 10, wherein the body portion is stacked with at least one body portion,
Wherein the body portion includes a carrier,
Wherein the reaction catalyst is fixed to the carrier.
13. The method of claim 12, wherein the carrier is selected from the group consisting of polymer fibers, electrically conductive polymers, porous particles, spherical particles, nanoparticles, beads, carbon nanotubes, wires, filaments, graphene, Wherein at least one of the at least one reactant and the at least one reactant is present in the liquid-liquid interface.
13. The process of claim 12, wherein the carrier is fixed to the reaction catalyst by adsorption, ionic bonding, covalent bonding or an adhesive material.
The process according to claim 10, wherein the reaction catalyst comprises at least one selected from an enzyme as an organic catalyst and an inorganic catalyst.
16. The method of claim 15, wherein the enzyme is selected from the group consisting of a carbonic anhydrase, a trypsin, a chymotrypsin, a subtilisin, a papain, a suramolysin, a lipase, a peroxidase, a tyrosinase, a lacase, a cellulase, a xylanase, , At least one selected from the group consisting of organic phosphohydrolase, choline esterase, glucose oxidase, pyranose oxidase, formate dehydrogenase, aldehyde dehydrogenase, alcohol dehydrogenase, glucose dehydrogenase, and glucose isomerase The liquid-liquid interface being a reaction product.
The method of claim 15, wherein the inorganic catalyst is selected from the group consisting of platinum, platinum, rhodium, palladium, lead, iridium, rubidium, iron, nickel, zinc, cobalt, copper, manganese, titanium, ruthenium, silver, molybdenum, tungsten, Characterized in that it comprises at least one selected from the group consisting of antimony, tin, bismuth, barium, osmium, nitrogen oxide, copper oxide, manganese oxide, titanium oxide, vanadium oxide and zinc oxide. Reactant conversion process.
17. The method of claim 16,
Wherein the enzyme forms an enzyme aggregate through cross-linking between enzymes using a cross-linking agent.
17. The method of claim 16,
The enzyme precipitates an enzyme through a quartz agent,
A process for the conversion of a reactant at a liquid-liquid interface, characterized in that an enzyme aggregate is formed through crosslinking between enzymes using a crosslinking agent.
The method of claim 18 or 19, wherein the cross-linking agent is selected from the group consisting of diisocyanate, dianhydride, diepoxide, dialdehyde, diimide, 1-ethyl-3-dimethylaminopropylcarbodiimide, glutaraldehyde, bis (Imidoesters), bis (succinimidyl esters), diacid chlorides, dopamine, compounds containing a dapamine-derived catechol group, jenipine, and ethylene glycol diglycidyl ether A process for the conversion of a reactant at a liquid-liquid interface.
The method of claim 19, wherein the quencher is selected from the group consisting of methanol, ethanol, 1-propanol, 2-propanol, butyl alcohol, acetone, polyethylene glycol, ammonium sulfate, sodium chloride, sodium sulfate, sodium phosphate, potassium chloride, And an aqueous solution thereof. The process for converting a reactant in a liquid-liquid interface.
11. The apparatus of claim 10, wherein the body is a lattice-like planar structure,
Wherein the body is formed with an opening through which reactants can be accessed from the outside to the inside.
11. The device of claim 10, wherein the floating portion has at least one void,
Wherein the suspension control material comprises at least one material selected from the group consisting of air, nitrogen, oxygen, argon, carbon dioxide, neon, ozone, helium, methane, xenon, krypton, hydrogen,
Wherein the volume of the voids is adjusted to adjust the average density of the structure.
11. The method of claim 10, wherein the average density of the structure is controlled by changing at least one of a material and a composition of the body portion and the floating portion.
The method of claim 10, wherein the material of the body portion and the material of the floating portion are each independently selected from the group consisting of nitrile-butadiene-styrene (ABS), polycarbonate (PC), polyvinyl alcohol (PVA), polystyrene (PS), polylactic acid, Polyacrylic acid, polymethyl methacrylate, polymethyl methacrylate, polymethyl methacrylate, polymethyl methacrylate, polymethyl methacrylate, polymethyl methacrylate, polymethyl methacrylate, polymethyl methacrylate, polymethyl methacrylate, Characterized by comprising at least one selected from the group consisting of siloxane, polystyrene-co-maleic anhydride, Teflon, collagen, nylon, cellulose, chitosan, glass, gold, silver, The process of converting the reactants at the liquid-liquid interface

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