KR20160147421A - Cube-shaped valve block device installed in simulated moving bed process system - Google Patents

Abstract

The present invention relates to a cube type valve block device installed to a simulated moving bed process system. More particularly, the cube type valve block device is formed between a main pipe transferring various solvents and a column separating a mixed solvent, and has a plurality of transfer paths formed inside for transferring a solvent to a desired place. Thus, the cube type valve block device excludes a conventional pipe line having a complex structure, and makes the flow in the transfer paths smooth by minimizing interruptions in the transfer paths, thereby minimizing a dead volume generated in the pipe line caused by the interruptions. Also, the simulated moving bed process system has efficiency increased by imparting a gradient to the transfer paths in which solvents flow, and by completely discharging the solvents.

Description

[0001] The present invention relates to a cube-type valve block device installed in a simulated moving bed process system,

The present invention relates to a cube-type valve block device installed in a simulated moving bed process system, and more particularly to a cube-type valve block device installed between a main pipe to which various solvents are transferred and a column separating a mixed solvent, The piping line of the conventional complex structure is eliminated and the piping between each flow is minimized to smooth the flow, thereby minimizing the dead volume generated in the piping, And more particularly, to a cube-type valve block device installed in a simulated moving bed process system in which solvent is completely discharged by giving an inclination to a transfer path through which solvent flows, thereby increasing the efficiency of the simulated moving bed process system.

In general, the Simulated Moving Bed (SMB) technology is a technique that moves the mobile phase and the stationary phase countercurrently in a batch chromatography, (True Moving Bed) technique in which the material is moved in the direction of the flow of the fixed bed due to the difference in adsorption strength between the adsorbent and the adsorbed material of the adsorbent, It is a continuous separation chromatographic process simulating the movement of a fixed bed while organically operating with a valve capable of continuously changing the flow of the mobile phase.

In order to obtain the desired separation in the continuous transfer layer, the column switching interval, the discharge flow rate of each separated product, and the circulating solvent flow rate must be precisely controlled. Since each process variable has a large time-varying characteristic and a nonlinear characteristic, There are many difficulties in changing control elements while monitoring variables at the same time.

In addition, in the conventional SMB processing apparatus, piping lines where the interference and flow intersect each other are complicated, and efficient operation is impossible.

Japanese Patent Application Laid-Open No. 10-2012-0008594

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems,

A plurality of transfer paths are formed inside the main pipe for separating the mixed solvent from the main pipe to which the various solvents are transferred and the solvent is transferred to a desired location, thereby eliminating the conventional complicated piping lines, It is possible to minimize the dead volume generated in the piping and to provide a gradient to the conveying path through which the solvent is completely discharged to increase the efficiency of the simulated moving bed process system It is an object of the present invention to provide a cube-type valve block device installed in a simulated moving bed process system.

In addition, a plurality of valve blocks can be freely adjusted in accordance with the shape of the flow chip so that the flow path can be freely adjusted while minimizing the dead zone where the solvent is mixed and the solvent is accumulated Another object is to provide a cube-type valve block device installed in a highly scalable simulated moving bed process system.

In order to accomplish the above object, the present invention provides a cube-type valve block device installed between a main pipe through which a mixed solvent or a pure solvent is transferred and a column separating a solvent mixed therewith,

A plurality of main pipes connected to each of the main pipes to supply a mixed solvent and a pure solvent and connected to the column to transfer the introduced mixed solvent and pure solvent to the column, A main block;

A connection block connected between the plurality of main blocks to divide the function of introducing or discharging the solvent through the main block;

And an open / close valve connected to the upper and lower portions of the main block and the connection block for selectively controlling the transfer of the solvent by opening and closing the cube-type valve block device. .

According to another aspect of the present invention, there is provided a main block comprising: a plurality of main flow path inlets formed on one end surface of a main block to be connected to an outlet side of a column;

A plurality of main channel outlets formed on an opposite side of the main channel inlet port and connected to the inlet side of the column;

A solvent inflow / outflow port formed on one side of the main block and through which the solvent is introduced or discharged by the function of the connection block;

And a plurality of valve connectors formed on the upper and lower surfaces of the main block and connected to the on-off valves. The present invention relates to a cube-type valve block device installed in a simulated moving bed process system.

In the main block of the present invention, a main flow path is formed in the main flow path inlet and the main flow path outlet to communicate with each other to transfer the solvent to the column.

A solvent transfer path formed to communicate with the solvent inflow / outflow port and to which a mixed solvent or a pure solvent is transferred;

A solvent connecting passage formed to communicate with the valve connecting port at right angles to the main flow path and the solvent transfer path and to transfer the solvent transferred through the solvent transfer path to the main flow path or to transfer the solvent of the main flow path to the solvent transfer path, The present invention relates to a cube-type valve block device installed in a simulated moving bed process system.

In addition, the connection block of the present invention is connected between the plurality of main blocks, and main block connection ports are formed on both sides so as to communicate with the main flow port and the main flow path outlet of the main block, And a plurality of valve connection holes are formed in the valve body, respectively.

In addition, in the connecting block of the present invention, a solvent transfer path for transferring the solvent to the main block is formed by connecting the main block connecting port and the valve connecting port to each other. In the cubic valve block unit .

The cube-type valve block device installed in the simulated moving bed process system of the present invention is characterized in that the main blocks are connected in series on both sides of the connecting block, .

The main block of the present invention is connected in series to both sides of the connection block, and a plurality of the main blocks are connected in series according to the quantity of the mixed solvent and the pure solvent. The cubic valve Block device.

The main block of the present invention is connected in series to both sides of the connection block, and a plurality of the main blocks are connected in parallel according to the number of the columns. will be.

In addition, in the present invention, the block bonding is performed by applying heat and pressure at a high temperature in a state of attaching a thermally fusible film between the block and the block, wrapping the edges of the blocks through the clamp, and then pressing and clamping the clamp on the block by the fixing member To a cube-type valve block device installed in a simulated moving bed process system.

As described above, the cubic valve block device installed in the simulated moving bed process system of the present invention is formed between the main pipe through which various solvents are transferred and the column separating the mixed solvent, And the solvent is transported to a desired location, the piping line of the conventional complicated structure is eliminated, the piping between each flow is minimized to smooth the flow, thereby minimizing the dead volume generated in the piping, It is possible to increase the efficiency of the simulated moving bed process system by completely discharging the solvent by giving an inclination to the conveying passage through which the solvent flows.

In addition, a plurality of valve blocks can be freely adjusted in accordance with the shape of the flow chip so that the flow path can be freely adjusted while minimizing the dead zone where the solvent is mixed and the solvent is accumulated It has an excellent scalability.

1 is a perspective view of a schematic simulated moving bed process system in accordance with an embodiment of the present invention,
2 is a perspective view of a cube-type valve block device according to an embodiment of the present invention,
3 is a perspective view of a main block according to an embodiment of the present invention,
4 is a perspective view illustrating a connection block according to an embodiment of the present invention,
5 to 7 are schematic views showing an operational flow of a cube-type valve block apparatus according to an embodiment of the present invention.

The present invention having such characteristics can be more clearly described by the preferred embodiments thereof.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Before describing in detail several embodiments of the present invention with reference to the accompanying drawings, it is to be understood that the present invention is not limited to the details of construction and the arrangement of components shown in the following detailed description or illustrated in the drawings will be. The invention may be embodied and carried out in other embodiments and carried out in various ways. It should also be noted that the device or element orientation (e.g., "front," "back," "up," "down," "top," "bottom, Expressions and predicates used herein for terms such as "left," " right, "" lateral," and the like are used merely to simplify the description of the present invention, Or that the element has to have a particular orientation. Also, terms such as " first "and" second "are used herein for the purpose of the description and the appended claims, and are not intended to indicate or imply their relative importance or purpose.

Therefore, the embodiments described in the present specification and the configurations shown in the drawings are merely the most preferred embodiments of the present invention, and not all of the technical ideas of the present invention are described. Therefore, It should be understood that various equivalents and modifications may be present.

FIG. 1 is a perspective view of a schematic simulated moving bed process system according to an embodiment of the present invention, FIG. 2 is a perspective view of a cubic valve block device according to an embodiment of the present invention, FIG. FIG. 4 is a perspective view illustrating a connection block according to an embodiment of the present invention. Referring to FIG.

As shown in FIGS. 1 to 4, the cubic valve block device installed in the simulated moving bed process system of the present invention includes a main pipe through which a mixed solvent or a pure solvent is respectively transferred, and a column And 1) to selectively transfer the solvent in various directions. The cube-type valve block device comprises a main block 10, a connecting block 20, and an on-off valve 30.

Here, the column (1) separates the mixed solvent introduced by a material such as resin filled in the inside at a time difference so that the resin prevents the solvent from being mixed and the solvent is separated into the pure solvent.

The pure solvent transferred through the main pipe is a fluid for transferring a mixed solvent, and usually an organic solvent such as water is used.

As shown in FIGS. 1 to 3, the main block 10 is connected to each main pipe to introduce a mixed solvent and a pure solvent for transfer. The mixed solvent and the pure solvent are introduced into the column 1 And is connected to the column 1 for transferring the solvent, and guides the solvent to discharge the solvent separated from the column 1 to the outside.

Here, the main block 10 is formed in a rectangular or square cube shape, and a through hole is formed on each surface.

2 to 3, a plurality of main channel inlet ports 11 are formed on one end surface of the main block 10 so as to be connected to the outlet side of the column 1, A plurality of main flow path outlets 12 connected to the inlet side of the column 1 are formed on the opposite surface of the main flow path 11.

In addition, solvent inflow / outflow ports 13 and 14 are formed on one surface of the main block 10, that is, both side surfaces of the surface on which the main flow path inlet port 11 and the main flow path port 12 are formed, The solvent is introduced or discharged through the main block 10 by the function. At this time, the solvent inflow / outflow ports 13 and 14 may be formed on both sides or only one side of the main block 10 depending on the position of the main block 10, as shown in FIGS. 3A and 3B.

On the upper and lower surfaces of the main block 10, a plurality of valve connection ports 15 connected to the on-off valve 30 are formed. At this time, four valve connecting ports 15 are formed on one surface of the main block 10, and two pairs of the valve connecting ports 15 serve as inflow / outflow functions. The other main flow path inlet ports 11, main flow path outlet port 12 and solvent inlet / outlet ports 13 and 14 are formed on each side of the main block 10, but the installation conditions of the cube- The number of designs can be changed by function and environment.

The main block 10 has a through hole (main channel inlet port 11, main channel outlet port 12, solvent inlet / outlet ports 13 and 14, and valve connection port 15) The flow path connecting the through-holes is formed in the main block 10. The flow path connecting the through-holes is formed in the main block 10, as shown in FIG.

3, the main flow path 16 is formed so that the main flow path inlet 11 and the main flow path outlet 12 are communicated with each other, and the main flow path 10 is formed on both sides of the main block 10, A solvent transfer path 17 is formed so that the solvent inflow / outflow ports 13 and 14 are formed so as to communicate with each other and the valve connection port 15 is communicated with the main path 16 and the solvent transfer path 17 at right angles, A solvent connecting path 18 is formed.

Here, the main passage 16 and the solvent conveying passage 17 are formed in a straight line so as to be connected only to through-holes positioned in the same line, and the solvent connecting passage 18 is perpendicularly communicated therewith. 3, the solvent transfer path 17 is formed in a " + "shape in communication with the solvent connecting path 18, and the main path 16 communicates with the solvent connecting path 18 to form a" So that the solvent transferred through the solvent transfer path 17 through the solvent connecting path 18 is transferred to the main flow path 16 or the solvent of the main flow path 16 is transferred to the solvent transfer path 17 .

The solvent connecting paths 18 are connected to one main passage 16 and a solvent conveying path 17 so as to be connected to valve connecting ports 15 formed on four sides of the main block 10, A connection passage 18 is formed and connected to the valve connection port 15.

The solvent transfer path 17 communicates solvent inlet / outlet ports 13 and 14 formed on both sides of the main block 10. As described above, the solvent inlet / 3 (B), the end of the solvent conveyance path 17 is directly communicated with the solvent connection passage 18 when formed on one side of the block 10 so that it is formed in the form of " do. The solvent transfer process by the above structure will be described in detail in the following method.

The connection block 20 is formed in a rectangular or square cube shape as shown in FIG. 2 or 4, and is connected between the plurality of main blocks 10 so that the solvent flows through the main block 10 It serves to distinguish the function of discharge.

The connecting block 20 is connected between the plurality of main blocks 10. The connecting block 20 is provided on both sides of the main block 10 so as to communicate with the main flow inlet 11 and the main flow outlet 12 of the main block 10, And a plurality of valve connectors 22 connected to the on / off valve 30 are formed on the upper and lower surfaces of the connection block 20, respectively. At this time, the main block connecting ports 21 are formed in accordance with the number of the main flow inlet 11 or the main flow outlet 12.

The connection block 20 is provided with a solvent transfer path 23 for connecting the main block connection port 21 and the valve connection port 22 to transfer the solvent to the main block 10, The path 23 is formed in the form of "┓, ┛ 'on the front surface as shown in Fig.

1 and 2, the on / off valve 30 is connected to the upper and lower portions of the main block 10 and the connection block 20, and is connected to the valve connection ports 15 and 22, So that the solvent is selectively transported.

Here, the structure and function of the on-off valve 30 is a general electronic on-off valve, which is operated by a control unit (not shown), so that no other description is given.

2, the main block 10 is formed on both sides of the connecting block 20, that is, the two main blocks 10 are connected to each other The main block 10 and the connection block 20 are connected in series in a manner that the block 20 is formed.

The main block 10 is connected in series to both sides of the connecting block 20, and a plurality of the main blocks 10 are further connected in series as the types of the mixed solvent and the pure solvent are varied. That is, one main block 10 is formed on both sides of the connection block 20, and the other main blocks 10 are attached to one side of the main block 10 The quantity increases.

2, the main block 10 on the left side of the connection block 20 is a block into which mixed solvent and pure solvent flows, and the main block 10 on the right side is separated from the column 1 Is the block from which the pure solvent is discharged. Therefore, the left main block 10 is provided with a solvent inlet 13 of the solvent inlet / outlet ports 13 and 14, and the right main block 10 is provided with a solvent outlet port 13 of the solvent inlet / (14) is formed.

The main block 10 is connected in series to both sides of the connection block 20. In this state, the main blocks 10 are connected in parallel according to the number of the columns 1, 20) are also increased in parallel. However, the main blocks 10 formed in parallel may communicate with each other, while the connection blocks 20 formed in parallel are not in communication with each other. At this time, the connection block 20 is connected to the main block 10 only in series, and is not communicated in parallel.

As shown in FIG. 3 (B), the solvent inflow / outflow ports 13 and 14 are formed on only one end surface of the last main block 10 of the main block 10 formed in parallel, And is connected to the valve connector 15 through the solvent conveying path 17.

In the meantime, the plurality of block joints are formed by bonding heat-sealing films between blocks and blocks, applying heat and pressure at a high temperature to each other, or wrapping the edges of connected blocks through a clamp (not shown) (Not shown) while clamping the clamp to the block.

When a block is joined to the clamp, a through hole is formed at the same position in the clamp according to the through hole formed in the block, and the clamp is connected to the block by the fixing member, (Not shown) are formed on one surface of the block so as to be coupled with the fixing member.

Hereinafter, a method of operating the cube-type valve block device in the simulated moving bed process system will be described in detail with reference to the drawings.

5 to 7 are schematic views showing an operational flow of a cube-type valve block apparatus according to an embodiment of the present invention.

As shown in FIGS. 5 to 7, in the method of operating the cube-type valve block device of the present invention, first, a plurality of columns 1 are provided. In the present invention, four columns (first column, second column, 3 column and 4 column) are formed, and one kind of mixed solvent is repeatedly circulated while separating through four columns (1), and the separated pure solvent is discharged to the outside.

First, as shown in FIGS. 5 to 6, the mixed solvent introduced through the solvent inlet 13 of the main block 10 is conveyed through the introduced pure solvent for transfer. First, through the first column 1, Flows through the main flow passage inlet 11 of the main block 10 on the column 1 side and is conveyed along the main flow passage 16 and then is conveyed to the second column 1 through the main flow passage outlet 12 , The solvent discharged from the second column 1 flows through the main flow passage inlet 11 of the main block 10 on the third column 1 side and is conveyed along the main flow passage 16, Is transferred to the third column 1 through the outlet 12 and the solvent passing through the fourth column 1 forms a circulating flow which is transferred to the first column 1 of the first column.

As described above, the solvent can be circulated and the external mixed solvent can be transferred to any one of the columns 1 to 4 of the column 1 according to the set conditions. Can be arbitrarily controlled according to the setting conditions.

Meanwhile, as shown in FIGS. 5 and 7, the mixed solvent is separated into the first pure solvent and the second pure solvent through the first column (1) to the fourth column (1) The solvent conveyed through the main flow path 16 is transferred to the solvent connecting path 18 by controlling the opening and closing of the opening and closing valve 30, To the solvent transfer path connected to the connection path (18), and is discharged to the outside through the solvent transfer path (17).

The separated pure solvent is discharged from the column 1 through the opening / closing control of the opening / closing valve 30 to the set condition It can be discharged arbitrarily.

Here, the introduction of the mixed solvent and the pure solvent for transfer and the outflow of the separated pure solvent are separated by blocking the opening / closing valve 30 of the connection block 20.

Thus, the solvent flow of the present invention can be controlled according to the conditions of the simple flow control valve and various flow paths in the block, thereby reducing the dead-leg in the SMB equipment and producing a high purity substance In order to maximize the efficiency of the SMB production process, it is possible to design the total line volume excluding the column within 5% of the column volume.

10: Main block 11: Main flow path inlet
12: Main flow path outlet 13: Solvent inlet
14: solvent outlet 15,22: valve connector
16: main flow path 17: solvent transfer path
18: solvent connection path
20: connection block 21: main block connector
22: valve connection port 23: solvent delivery path
30: opening / closing valve

Claims (9)

A cube-type valve block device installed between a main pipe through which a mixed solvent or a pure solvent is respectively transferred and a column separating a solvent mixed, and selectively transporting the solvent in various directions,
A plurality of main pipes connected to each of the main pipes to supply a mixed solvent and a pure solvent and connected to the column to transfer the introduced mixed solvent and pure solvent to the column, A main block;
A connection block connected between the plurality of main blocks to divide the function of introducing or discharging the solvent through the main block;
An on / off valve connected to the upper and lower portions of the main block and the connection block to selectively control the solvent to be transferred by opening and closing;
Wherein the cube-type valve block device is installed in the simulated moving bed process system.
The apparatus of claim 1,
A plurality of main flow path inlets formed on one end surface of the main block to be connected to an outlet side of the column;
A plurality of main channel outlets formed on an opposite side of the main channel inlet port and connected to the inlet side of the column;
A solvent inflow / outflow port formed on one side of the main block and through which the solvent is introduced or discharged by the function of the connection block;
A plurality of valve connectors formed on upper and lower surfaces of the main block and connected to the on-off valves;
Wherein the cube-type valve block device is installed in the simulated moving bed process system.
3. The apparatus according to claim 2, wherein, in the main block,
A main flow path formed in the main flow path inlet and the main flow path outlet to communicate with each other to transfer the solvent to the column;
A solvent transfer path formed to communicate with the solvent inflow / outflow port and to which a mixed solvent or a pure solvent is transferred;
A solvent connecting passage formed to communicate with the valve connecting port at right angles to the main flow path and the solvent transfer path and to transfer the solvent transferred through the solvent transfer path to the main flow path or to transfer the solvent of the main flow path to the solvent transfer path, ;
Wherein the cube-type valve block device is installed in the simulated moving bed process system.
3. The method of claim 2,
The connecting block is connected between the plurality of main blocks. The main block connecting port is formed on both sides of the main block so as to communicate with the main channel inlet and the main channel outlet. A plurality of valves And a connecting hole is formed in the valve body.
5. The method of claim 4,
And a solvent transfer path for transferring the solvent to the main block through the main block connection port and the valve connection port is formed in the connection block.
6. The method according to any one of claims 1 to 5,
Wherein the cube-type valve block device installed in the simulated moving bed process system is installed in the simulated moving bed process system, wherein the main block is connected in series to both sides of the connecting block.
The method according to claim 6,
Wherein the main block is connected in series to both sides of the connection block, and a plurality of the main blocks are connected in series according to the number of mixed solvents and pure solvents.
The method according to claim 6,
Wherein the main blocks are connected in series to both sides of the connection block, and a plurality of the main blocks are connected in parallel according to the number of the columns.
The method according to claim 6,
The block bonding is performed by applying heat and pressure at a high temperature in a state where a block of a thermally fusible film is stuck between the block and the block, wrapping the edges of the blocks through a clamp, A cube-type valve block device installed in the simulated moving bed process system.

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