KR20160123951A - Biometric information measuring sensor, Biometric information measuring system and Measuring method biometric information using the same - Google Patents

Abstract

Disclosed are a biometric information measuring sensor, a biometric information system, and a method for measuring biometric information using the same. The disclosed biometric information measuring sensor includes at least one bio-marker measuring area for measuring a bio-marker inside an object to be examined. An electrode unit having an operation electrode, an opponent electrode, and a reference electrode can be formed in the bio-marker measuring area. A plurality of needle units invaded or inserted into the object to be examined can be formed in each electrode unit. Needle units formed in an electrode unit of the same bio-marker measuring areas can have the same length, and needle units formed in an electrode unit of different bio-marker measuring areas can have different lengths.

Description

TECHNICAL FIELD [0001] The present invention relates to a biometric information measuring sensor, a biometric information system, and a biometric information measuring method using the biometric information measuring sensor,

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sensor for measuring biometric information using a micro needle inserted into a living body, and a biometric information measurement method using the same.

As interest in health increases, various types of bioinformation measuring devices are being developed. The biometric information detection method can be largely divided into an invasive method and a noninvasive method. Various types of biometric information measuring apparatus can be used according to the biometric information of the subject to be measured.

In order to detect a change in the state of a subject, it is required to accurately detect the presence and concentration change of a bio-marker, i.e., biological analyte, which is a biological indicator inside the subject. The change of the state of the subject can be objectively determined by measuring the presence and concentration change of the biological analysis objects including the biomarkers.

In order to measure the presence and concentration change of the biomarkers existing in the living body of the subject, blood can be collected from the subject. However, repeated blood sampling from the subject may cause pain to the subject, and it may not be easy to accurately analyze changes in the biological analysis subject.

In one aspect of the present disclosure, there is provided a bio-information measuring sensor having a structure capable of measuring the presence or concentration change of biomarkers that may be present inside a subject.

In another aspect of the present disclosure, a method of measuring biometric information using a bio-information measuring sensor is provided.

A plurality of biomarker measurement regions;

An electrode unit formed on the biomarker measurement area and including a working electrode and a counter electrode spaced apart from the working electrode;

And a needle portion formed on the electrode portion,

At least some of the needle portions formed in different biomarker measurement regions among the plurality of biomarker measurement regions have different lengths.

The electrode unit may further include a reference electrode spaced apart from the working electrode and the counter electrode.

The counter electrode may have a larger surface area than the working electrode.

The nibs may be formed on the working electrode and the counter electrode, respectively.

And an enzyme formed on the needle portion formed on the working electrode.

The needle portions formed in the same biomarker measurement region among the plurality of biomarker measurement regions have the same length,

Needle portions formed in different biomarker measurement regions may have different lengths.

Wherein the biomarker measurement region includes a first biomarker measurement region having a relatively long needle portion longer than other biomarker measurement regions,

The lengths of the needle portions of the biomarker measurement region other than the first biomarker measurement region may be substantially equal to each other.

The needle portions having different lengths may have different regions to which the enzymes are attached.

The areas of the areas where the enzymes are attached to the needle parts having different lengths may be equal to each other.

The number of needle units of the needle parts having different lengths may include needle parts having different numbers.

The cross section of the needle portion may have a shape of at least one of a circle, an ellipse, and a polygon.

And a transmitter formed in one area of the bio-information measuring sensor.

A plurality of biomarker measurement areas, electrode parts formed on the biomarker measurement area, the electrode parts including a working electrode and a counter electrode spaced apart from the working electrode, and a needle part formed on the electrode part, Wherein at least some of the needle portions formed in different biomarker measurement regions of the biomarker measurement region of the biomarker measurement region have different lengths; And

And a terminal unit for calculating the biometric information of the subject from the electrical signals transmitted from the biometric information measurement sensor.

Wherein the terminal unit comprises: a communication unit for transmitting an electric signal transmitted from the biometric information measurement sensor; And a controller for calculating a result of the biometric information of the subject using the electrical signal.

A biometric information measuring method using a biometric information measuring sensor,

Attaching the biometric information measurement sensor to a subject,

The present invention provides a biometric information measuring method for receiving an electrical signal detected from the needle portion inserted into the body of a subject and measuring the concentration of the biomarker corresponding to the electrical signal.

The concentration values in the blood vessels of the biomarkers can be calculated by applying weights to the concentration values of the biomarkers calculated from the electrical signals measured from the needle portions.

The length of the needle portion in which the enzyme corresponding to the biomarker having a relatively high concentration in the blood vessel of the subject among the biomarkers is disposed is shorter than the length of the needle in which the enzyme corresponding to the relatively low concentration biomarker in the blood vessel of the subject is placed Can be formed shorter than the length of the portion.

The present disclosure provides a biometric information measurement sensor including needles having different lengths. It is possible to reduce a measurement error in the presence and concentration change of various biomarkers in the subject. In the measurement of biometric information, it is possible to reduce the pain of the subject by eliminating the need for a repeated blood collection process on the subject.

1A is a schematic view of a bio-information measuring sensor according to the disclosure.
1B is a view showing a biomarker measurement area of the bio-information measuring sensor according to the disclosure.
2A is a view showing the attachment of a biometric information measurement sensor according to the disclosure to a subject.
FIG. 2B is a view showing a structure in which an enzyme is attached to a needle portion of a bio-information measuring sensor according to the disclosure shown in FIG. 2A. FIG.
2C is a view showing a modified example of the needle portion of the biometric information measurement sensor according to the disclosure.
3A and 3B are plan views showing an electrode structure of a bio-information measuring sensor according to the disclosure.
4A to 4C are views showing various examples of the electrode structure of the bio-information measuring sensor according to the disclosure.
FIG. 5 is a graph showing that a biomarker diffused in a subject is measured with time using the bio-information measuring sensor according to the disclosure.
FIG. 6 is a graph showing the results of measurement of biomarkers diffused in a subject using the biomedical information measuring sensor according to the disclosure, as a concentration value according to the measurement position.
7 is a view showing a modification of the biometric information measurement sensor according to the disclosure.
FIG. 8 is a diagram illustrating transmission of biometric information measured from a subject to the analysis unit using the biometric information measurement sensor according to the disclosure. FIG.
FIG. 9 is a block diagram illustrating a biometric information measurement sensor according to the disclosure and a biometric information analysis system including the same.
FIG. 10 is a flowchart schematically illustrating a method of measuring biometric information using the bio-information measuring sensor according to the present disclosure.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. Like reference numerals in the drawings may refer to like elements. The size and thickness of each component shown in the drawings may be exaggerated for clarity of description and are arbitrarily shown for convenience of explanation, and thus the present invention is not necessarily limited to the illustrated ones. It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The appearances of the singular forms herein may include a plurality of representations unless expressly limited otherwise.

1A is a schematic view of a bio-information measuring sensor according to the disclosure.

1A, the bio-information measuring sensor 100 may include a base 10 formed of an insulating material, and the base 10 may include at least one biomarker measuring area A1, A2, A3, . For example, in FIG. 1, the base 10 is formed of four biomarker measurement regions of a first region A1, a second region A2, a third region A3 and a fourth region A4 . However, the present invention is not limited thereto, and the number of the biomarker measurement regions is not limited. The first electrode unit 22 is formed in the first area A1 and the first electrode unit 22 is formed of a first electrode unit 22 including at least one needle formed into a probe shape so as to be inserted into the body of the subject. The needle portion N1 may be formed. The second electrode portion 24 may be formed in the second region A2 and the second electrode portion 24 may include the second needle portion N2. The third electrode portion 26 may be formed on the third region A3 and the third electrode portion 26 may include the third needle portion N3. The fourth electrode A4 may include a fourth electrode portion 28 and the fourth electrode portion 28 may include a fourth needle portion N4.

The first electrode unit 22 may include a working electrode having an enzyme capable of detecting a biomarker and a counter electrode spaced apart from the working electrode. electrode. The first needle unit N1 may be formed on the working electrode, the counter electrode, or the reference electrode, and an enzyme capable of detecting the biomarker only on the first needle unit N1 formed on the working electrode is formed by coating or the like . This will be described later.

The second electrode portion 24, the third electrode portion 26, and the fourth electrode portion 28 may be similarly applied to the first electrode portion 22. That is, the second electrode unit 24, the third electrode unit 26, and the fourth electrode unit 28 may also include a working electrode and a counter electrode spaced apart from the working electrode, . The second needle portion N2, the third needle portion N3, or the fourth needle portion N4 may be formed on the working electrode and the counter electrode. An enzyme capable of detecting the biomarker may be formed in the second needle portion N2, the third needle portion N3, or the fourth needle portion N4.

The first needle portion N1, the second needle portion N2, the third needle portion N3 and the fourth needle portion N4 of the bioinformation measuring sensor 100 according to the disclosure shown in FIG. May be formed to have a height. That is, the needle portions N1, N2, N3, and N4 formed in the biomarker measurement areas A1, A2, A3, and A4 may have different lengths. The length of the first needle portion N1 is the longest and the length of the second needle portion N2, the third needle portion N3 and the fourth needle portion N4 may be shorter. The needle portions N1, N2, N3, and N4 are areas that can be invaded or inserted into the surface of the subject during the measurement of the biometric information. The needle portions N1, N2, N3, and N4 may be invaded or inserted into the surface of the subject to measure the presence and concentration of the biomarkers .

The lengths of the needle portions N1, N2, N3 and N4 are different from each other. However, the lengths of the needle portions N1, N2, N3 and N4 are not limited thereto, And the lengths of the remaining needle portions may be equal to each other. For example, the length of the first needle portion N1 is longer than the length of the remaining needle portions N2, N3, N4, and the lengths of the second needle portion N2, the third needle portion N3, N4 may be substantially equal to each other.

1A, the first to fourth regions A1 to A4, which are biomarker measurement regions, are shown in the base 10 of the bio-information measuring sensor 100 as having a 2 × 2 array structure. However, And the first area A1 to the fourth area A4 may have an array structure of 2 × 3, 3 × 3, 4 × 2, 4 × 3, 4 × 4, It may also have an array structure.

1B is a view showing a biomarker measurement area of the bio-information measuring sensor according to the disclosure.

Referring to FIG. 1B, the n-th region An, which is a biomarker measurement region, may include a counter electrode 20a and a working electrode 20b. A needle portion N including a plurality of needles may be formed on the counter electrode 20a and the working electrode 20b. The number of needles formed in the needle portion N is not limited, and the needles may be formed on the counter electrode 20a and the working electrode 20b in various arrangements. For example, the portion of the needle (N) is in one direction the N needles comprises (N _11, N ₁₂ ..., N _1N), M (M is an integer) in the other direction (N is an integer) And an array of N * M needles including needles N ₁₁ , N ₂₁ ..., N _M1 . However, the shape of the needle of the needle portion N is not limited thereto.

FIG. 2A is a diagram showing the attachment of the bio-information measuring sensor 100 according to the disclosure to the subject SP. FIG.

1A and 2B, the needle portions N1, N2, N3 and N4 of the bioinformation measuring sensor 100 are attached to the surface of the subject SP by being inserted or inserted. The depth to be inserted or inserted into the inspected object SP may vary depending on the heights of the needle portions N1, N2, N3 and N4 of the bioinformation measuring sensor 100. The subject SP may include a skin layer SP1, a dermis layer SP2 and a subcutaneous layer SP3 downward from the surface of the subject SP and a blood vessel capable of moving blood may be positioned below the dermis layer SP2. The first needle portion N1 having the longest length among the needle portions N1, N2, N3 and N4 of the bioinformation measuring sensor 100 according to the present disclosure is inserted or implanted into the dermal layer SP2 or the subcutaneous layer SP3, . When the bioinformation measuring sensor 100 is mounted on the subject SP, the distal end of the first needle portion N1 may penetrate to a position where some capillaries exist, Or may not be inserted.

The subject SP may be a person or an animal, a person, or a part of an animal as an object to be measured for biometric information. Examples of various types of biomarkers present in blood vessels of the subject SP include glucose, C-reactive protein (CRP), vitamin AST (aspartate aminortansferase), ALT alanin aminotrasferase, glutamate, uric acid, potassium, sodium, calcium or various female hormones. Biomarkers existing in the blood vessels of the subject SP may escape from blood vessels due to diffusion and may exist in body fluids such as intracellular fluids, sweat, saliva, etc., and may tend to decrease gradually in accordance with the diffusion distance from blood vessels . When the length of the needle portions N1, N2, N3, and N4 of the respective measurement regions is diversified, the needle portions N1, N2, N3, N4) can be measured simultaneously according to the concentration. The lengths of the needle portions N1, N2, N3 and N4 suitable for the concentration measurement values of the respective biomarkers are calculated, and the lengths of the needle portions N1, N2, N3 and N4 are arranged in one biometric information measuring sensor, It can be measured at the same time.

The target biomolecule among the biomarkers existing in the subject SP of FIG. 2A can be referred to as a target biomolecule. An enzyme capable of binding with a specific biomolecule can be attached to the surface of the first needle unit N1 formed on the first working electrode 220 by a coating or the like so that a desired target biomolecule can be detected, (probe biomolecule). The probe biomolecule can change the electrical response corresponding to the electrical stimulation inside the subject (SP). The probe biomolecule can be selected according to the type of the target biomolecule to be detected.

Different probe bio-molecules may be attached to each of the needle portions N1, N2, N3, and N4. The first probe biomolecule may be attached to the surface of the first needle portion N1 of the first electrode portion 22 and the surface of the second needle portion N2 of the second electrode portion 24, The third probe biomolecule and the fourth probe biomolecule may also be attached to the third needle portion N3 of the fourth electrode portion 26 and the fourth needle portion N4 of the fourth electrode portion 28, . There is no limitation on the kind of the first to fourth probe bio-molecules.

The first to fourth probe biomolecules are all the same type of biomolecules and can detect the difference in concentration of the same target biomolecules according to the position in the subject SP. The first to fourth probe biomolecules may include different types of probe biomolecules. Various biomarkers present in the blood of the subject (SP) may have different concentrations. For example, glucose has a concentration of 70 to 120 mg / dL, CRP has a concentration of 150 to 500 ug / dL, and vitamin C has a concentration of 0.4 to 1.5 mg / dL. In order to measure a biomarker having a relatively low concentration, a needle having a relatively long length is inserted into the vicinity of the blood vessel of the subject SP to measure the concentration, It is possible to prevent the inaccuracy of measurement due to diffusion. In addition, when a biomarker having a relatively high concentration in a blood vessel is to be measured, a relatively accurate measurement result can be obtained even when a needle portion having a short length is employed.

2A, the first needle portion N1 is inserted to the lower end of the dermal layer SP2, the second needle portion N2 is inserted to the middle portion of the dermal layer SP2, the third needle portion SP3 is inserted into the dermal layer SP2 and the fourth needle portion SP4 is shown as having a length inserted into the uppermost portion of the dermal layer SP2. However, the lengths of the needle portions N1, N2, N3, and N4 of the bioinformation measuring sensor 100 according to the present disclosure are not limited thereto.

FIG. 2B is a view showing a structure in which an enzyme capable of binding specific biomolecules is attached to a needle portion of a bio-information measuring sensor according to the present disclosure shown in FIG. 2A so that a desired target biomolecule can be detected.

2A and 2B, on the surfaces of the needle portions N1, N2, N3 and N4 of the bioinformation measuring sensor 100, a desired biomarker, that is, a target biomolecule, Enzymes, i.e. probe biomolecules (P1, P2, P3, P4), can be coated, respectively. The probe biomolecules P1, P2, P3, and P4 need not be attached to the entire surfaces of the needle portions N1, N2, N3, and N4. The probe biomolecules P1, P2, P3, and P4 may be attached only to the ends of the needle portions N1, N2, N3, and N4, respectively.

For example, the first probe biomolecule P1 may be attached only to the end of the first needle portion N1, and the second probe biomolecule P2 may be attached only to the end of the second needle portion N2 have. The third probe biomolecule P3 may be attached only to the end of the third needle portion N3 and the fourth probe biomolecule P4 may be attached only to the end of the fourth needle portion N4. The first needle portion N1, the second needle portion N2, the third needle portion N3 and the fourth needle portion N4 are respectively inserted from the surface of the subject SP into the depths d1, d2, d3 And d4 (d1 > d2 > d3 > d4). At this time, the first probe molecule P1 attached to the end of the first needle portion N1 has a depth d1 and a depth d2 which are regions between the end portion of the first needle portion N1 and the end portion of the second needle portion N2 To the first needle portion N1 corresponding to the region between the first needle portion N1 and the second needle portion N2. The second probe molecule P2 is located only at the end of the second needle portion N2 corresponding to the region between the depths d2 and d3 which is an area between the end of the second needle portion N2 and the end of the third needle portion N3 . The third probe molecule P3 has a third needle portion N3 corresponding to an area between the depths d3 and d4 which is an area between the end of the third needle portion N3 and the end portion of the fourth needle portion N4, It can be attached only to the end portion. Further, the fourth probe molecule P4 may be attached only to the fourth needle portion N4 corresponding to the region between the depth SP of the subject SP and the depth d4.

The attachment regions of the probe biomolecules P1, P2, P3 and P4 attached to the needle portions N1, N2, N3 and N4 respectively correspond to the attachment portions of the needle portions N1 , N2, N3, N4). As described above, in the attachment region of the bio molecules P1, P2, P3, and P4 of the needle portions N1, N2, N3, and N4 of the sensor 100, The depth of the biomarker measurement depth can be divided by making the depths of the biomolecules P1, P2, P3, and P4 different from each other.

The biomarker which is exited from the blood vessel below the dermal layer SP2 of the subject SP and diffuses toward the surface of the subject SP is a first probe biomolecule attached to the end of the first needle portion N1 Lt; RTI ID = 0.0 > P1). ≪ / RTI > The areas of the second probe biomolecules P2 attached to the ends of the second needle portion N2 and the regions d2 to d3 of the third needle portion N3 closer to the surface of the skin of the subject SP, (D3 to d4) of the third probe biomolecule (P3) attached to the fourth needle portion N4 and the fourth probe biomolecule (P4) formed at the end of the fourth needle portion N4.

The probe biomolecules (P1, P2, P3, P4) can be the same or different kinds of enzymes, and there is no limitation. It is possible to detect the diffusion velocity and the concentration change of the biomarker by measuring the time and concentration at which the specific biomarker is released from the blood vessel of the subject SP and reaches the measurement depth of each of the needle portions N1, N2, N3 and N4 have. The biomolecules P1, P2, P3, and P4 of the respective needle portions N1, N2, N3, and N4 are dispersed in the direction of the surface of the specimen SP while a specific biomarker is extracted from the blood vessel of the subject SP, The concentration can be measured in the attachment region of the liquid. At this time, the time difference in which the biomarkers reach the same concentration value in each of the needle portions N1, N2, N3, and N4 is used, or the time difference between the biomarkers in the needle portions N1, N2, N3, The actual concentration of the biomarker in the blood vessel can be detected using the marker.

Various biomarkers present in blood vessels of the subject SP may have different concentrations. Low concentration biomarkers can be measured near the blood vessels using relatively long needles, and high concentration biomarkers are relatively accurate even when measuring the concentration using relatively short needles Can be measured.

2C is a view showing a modification of the needle portion of the bio-information measuring sensor according to the present disclosure.

2B and 2C, the lengths of the respective needle portions N1, N2, N3, and N4 may be different from each other, and the probe biomolecules P1, P2, P3, and P4 at the biomarker measurement depth, The areas of the attachment regions of the first and second electrodes may be different from each other. The results of measurement of the biomarkers of the respective needle portions N1, N2, N3 and N4 are compared with the attachment regions of the probe biomolecules P1, P2, P3 and P4 of the needle portions N1, N2, N3 and N4, It may be required to make the areas of the electrodes equal to each other. The number of unit needles of the needle portions N1, N2, N3, and N4 may be different from each other in order to make the biomarker measurement areas of the needle portions N1, N2, N3, and N4 of the bio- . 2C, the first needle portion N1 has two unit needles, the second needle portion N2 has four, the third needle portion N3 has six, and the fourth needle portion N4 has nine. It is to be understood that the present invention is not limited thereto. For example, the number of the unit needles of the second needle portion N2 may be larger than that of the first needle portion N1. N2, N3, and N4 of the needle units N1, N2, N3, and N4 so that the attachment areas of the probe biomolecules P1, P2, P3, and P4 of the respective needle portions N1, The numbers can be arbitrarily changed.

3A and 3B are plan views showing an electrode structure of a bio-information measuring sensor according to the present disclosure.

1 and 3A, the biomarker measurement areas A1, A2, A3, and A4 formed on the base 10 of the bio-information measuring sensor 100 are respectively provided with a first electrode unit 22, The third electrode portion 26, and the fourth electrode portion 28 are respectively formed on the surface of the substrate. Each of the electrode units may include counter electrodes 222, 242, 262, and 282 spaced apart from the working electrodes 220, 240, 260, and 280 and the working electrodes 220, 240, For example, the first electrode unit 22 may include a first working electrode 220 and a first counter electrode 222 spaced apart from the first working electrode 220. The first needle portion N1 may be formed to protrude into the first working electrode 220 and the first counter electrode 222, respectively. The first counter electrode 222 may be spaced apart from the first actuating electrode 220 and may have a relatively larger area than the first actuating electrode 220. This description can be similarly applied to the other electrode portions, that is, the second electrode portion 24 to the fourth electrode portion 28. That is, the counter electrodes 222, 242, 262, and 282 may have a larger surface area than the working electrodes 220, 240, 260, and 280 formed on the same electrode units 22, 24, 26, and 28. Needles N1, N2, N3 and N4 may be formed on the working electrodes 220, 240, 260 and 280 and the counter electrodes 222 and 242, 262 and 282, respectively.

The working electrodes 220, 240, 260 and 280, the counter electrodes 222, 242, 262 and 282 and the needle portions N1, N2, N3 and N4 may be formed of a conductive material, Metal oxides or conductive polymers. Specifically, it may be formed of a metal such as Al, Cu, Au, Ag, Pt, Ti or Mo, or a metal oxide such as ITO (indium tin oxide), AZO (aluminum zinc oxide) or IZO (indium zinc oxide). The working electrodes 220, 240, 260 and 280 and the counter electrodes 222, 242, 262 and 282 may be formed in such a manner that their surfaces are in contact with the skin layer SP1 of the subject SP have.

The needle portions N1, N2, N3 and N4 may be formed so as to protrude vertically upward from the surfaces of the working electrodes 220, 240, 260 and 280 and the counter electrodes 222, 242, 262 and 282, The width gradually decreases toward the distal end, and the distal end portion of the distal end portion may have a pointed shape. The lengths of the needle portions N1, N2, N3 and N4 protruding from the surfaces of the working electrodes 220, 240, 260 and 280 and the counter electrodes 222, 242, 262 and 282 are the same as the skin layers SP1), the dermal layer SP2, and the subcutaneous layer SP3. The thicknesses of the skin layer SP1, the dermal layer SP2 and the subcutaneous layer SP3 may vary depending on the region of the subject SP and the needle portions N1, N2, N3, and N4 may be arbitrarily selected from several hundreds of micrometers to several thousands of micrometers. The widths of the needle portions N1, N2, N3, and N4 can be arbitrarily selected from several micrometers to several hundreds of micrometers. The cross-sectional shapes of the needle portions N1, N2, N3, and N4 may be circular, elliptical, or polygonal, but are not limited thereto, and some may have a round shape and some may have a polygonal shape. The lengths of the needle portions N1, N2, N3 and N4 formed in the working electrodes 220, 240, 260 and 280 and the counter electrodes 222, 242, 262 and 282 in the same biomarker measuring region are the same can do.

When the needle portions N1, N2, N3 and N4 are inserted into the subject SP, the position of the subject SP with respect to the skin layer SP1, the dermal layer SP2 and the subcutaneous layer SP3 of the subject SP, The concentration of biomarkers diffused from blood vessels may vary. For example, when measuring the concentration of glucose, the concentration of the glaucose gradually decreases according to the distance from the blood vessel, and the needle portions N1, N2, N3, and N4 inserted at different positions in the subject SP ) Can be measured differently from each other. When an electrical signal is applied to the working electrodes 220, 240, 260, and 280 and the counter electrodes 222, 242, 262, and 282 in the state where probe bio-molecules are attached to the needle portions N1, N2, N3, , Different electrical signals may be output depending on the concentration of the target biomolecule bound to the probe biomolecule.

For example, the principle of detecting glucose in a biomarker will be described as follows. Glucose oxidase or glucose dehydrogenase may be bound to the needle portions N1, N2, N3, N4 of the working electrodes 220, 240, 260, 280 by a probe biomolecule by coating or the like. When the needle portions N1, N2, N3 and N4 are inserted into the subject SP, the glucose exiting from the blood vessel of the subject SP by diffusion differs from the glucose of the needle portions N1, N2, N3 and N4 Can be bound to an oxidizing enzyme. At this time, when an electrical signal is applied to the working electrodes 220, 240, 260 and 280, the glucose oxidase is activated and reacts with glucose to react with gluconic acid and hydrogen peroxide (H ₂ O ₂ ) Can be generated. And, hydrogen peroxide can decompose and generate electrons (e-). The resistance value of the intercellular fluid in the subject SP may change due to the electrons generated therein, and the measured current value may change. As a result, when glucose binds to the needle portions N1, N2, N3 and N4 of the working electrodes 220, 240, 260 and 280, a chemical reaction in which glucose is oxidized may occur. Depending on the concentration of glucose, Electrical signals having different sizes, for example, first to fourth electrical signals, may be detected.

3A, the counter electrodes 222, 242, 262 and 282 may serve as reference electrodes serving as a reference for the potential of the working electrodes 220, 240, 260 and 280, The reference electrode R in a ground state can be formed separately from the counter electrodes 222, 242, 262, and 282 as shown in FIG.

4A to 4C are plan views showing various examples of the electrode structure of the bio-information measuring sensor according to the present disclosure.

1, 3A, and 3B, the biomarker measurement areas A1, A2, A3, and A4 formed on the base 10 of the biometric information measurement sensor 100 are illustratively shown in the shape and arrangement structure thereof, It is not limited. For example, the biomarker measurement areas A1, A2, A3, and A4 may be formed to have different areas, and the shapes may be formed to be different from each other. The shapes of the working electrodes 220, 240, 260, and 280 and the counter electrodes 222, 242, 262, and 282 may be different from each other.

Referring to FIG. 4A, a working electrode 230 formed in a circular shape and a counter electrode 232 spaced apart from the working electrode may be formed in the biomarker measurement region An. As described above, the shape of the working electrode 230 is not limited, such as circular, round, and polygonal. Referring to FIG. 4B, a counter electrode 242 having a shape that surrounds the working electrode 240 while being separated from the rectangular working electrode 240 may be formed. Referring to FIG. 4C, a counter electrode 252 having a shape that surrounds the working electrode 250 while being spaced apart from the circular working electrode 250 may be formed. The counter electrodes 232, 242 and 252 may be formed to have a relatively larger area than the working electrodes 230, 240 and 250 so as to accommodate all the signals generated from the working electrodes 230, 240 and 250 The working electrodes 230, 240 and 250 and the counter electrodes 232, 242 and 252 may be provided with needle portions as shown in FIGS. 1, 3A and 3B. The working electrode 230 and the counter electrode 232 in the same biomarker measurement area An may be formed to have the same length but are not limited thereto.

FIG. 5 is a graph showing that the biomarker diffused in a subject is measured with time using the bio-information measuring sensor according to the present invention. Herein, the abscissa represents the time (Time) at which the biomarker emitted by the diffusion from the subject (SF) of FIG. 2B reaches each of the needle portions N1, N2, N3 and N4 of the biometric information measurement sensor 100 . The vertical axis represents the concentration of the biomarker emitted from the blood vessel of the subject SP.

2B and 5, a biomarker, for example, GLUCOSE, which is emitted from a blood of a subject SF, is contained in body fluids to form subcutaneous layer SP3, dermal layer SP2 of subject SR, As shown in FIG.

The concentration of glucose measured at the first needle portion N1 is higher than that at the second needle portion N2 and the concentration of glucose measured at the second needle portion N2 is higher than that at the third needle portion N3 And the concentration of glucose measured at the third needle portion N3 is higher than that at the fourth needle portion N4. In order for the concentration of glucose in each of the needle portions N1, N2, N3 and N4 to reach the same value G ', t1 in the first needle portion N1, t2 in the second needle portion N2, T3 is required for the needle portion N3, and t4 is required for the fourth needle portion N4. As described above, the time required for the biomarkers diffused from the blood to reach the respective needle portions N1, N2, N3 and N4 can be changed according to the subject SF to be measured. Even the same inspected object (SF) may vary depending on the state of the inspected object (SF) and the measurement time.

The bio-information measuring sensor according to the present invention includes needle portions N1, N2, N3 and N4 having various lengths so that a biomarker can detect a constant concentration value G 'in each needle portion N1, N2, N3, N4, T2, t3-t2, t4-t3, ...) of the time t that the blood vessel reaches the blood vessel (blood vessel) B, the respective weights can be tabulated and applied to the biomarker concentration calculation formula in the blood vessel. This is shown in Equation (1).

..., vn are weights in the respective needle portions N1, N2, ..., Nn, and C1, C2, ..., Vn are the weights of the biomarkers in the blood vessel, ..., Cn are the concentration values of the biomarkers measured at the respective needle portions N1, N2, ..., Nn. The biomarkers diffused and discharged from the blood of the subject SF may cause timelag according to the diffusion time to the body fluids or the interstitial fluid (ISF), and thus the measurement of the biomarkers An error may exist. As described above, the bioinformation measuring sensor 100 according to the present disclosure includes needle portions N1, N2, ..., Nn having various lengths, and each of the needle portions N1, N2, ..., (V1, v2, ..., vn) according to the difference of the time (time) at which the concentration value of the biomarker reaches a predetermined concentration value according to the measurement value.

FIG. 6 is a graph showing the results of measurement of biomarkers diffused in a subject using the bio-information measuring sensor according to the present invention as concentration values with time. Here, the abscissa represents the time (Time) at which the biomarker emitted by the diffusion from the subject (SF) of FIG. 2B reaches the respective needle portions N1, N2, N3 and N4 of the bioinformation measuring sensor 100 . The vertical axis represents the concentration of the biomarker emitted from the blood vessel of the subject SP.

2B and 6, a biomarker, for example, Glucose, which is emitted from a blood of a subject SF, is contained in body fluids to form subcutaneous layer SP3, dermis layer SP2 of subject SR, As shown in FIG. After the same time t 'elapses, the concentration of glucose measured at the first needle portion N1 is higher than that of the second needle portion N2, and the concentration of glucose measured at the second needle portion N2 is The concentration of glucose measured at the third needle portion N3 is higher than that of the third needle portion N3, and the concentration of glucose measured at the third needle portion N3 is higher than that of the fourth needle portion N4. The bio-information measuring sensor according to the present disclosure includes needle portions N1, N2, N3, and N4 having various lengths, and biopsies at the respective needles N1, N2, N3, and N4 at predetermined time t ' The weights can be applied to the concentration values of the markers and applied to the equation of the biomarker concentration in the blood. This is shown in Equation (2).

Wn are the concentration weights in the respective needle portions N1, N2, ..., Nn, and C1, C2, ..., Nn are the concentration values of the biomarkers in the blood vessel, for example glucose, , ..., Cn are the concentration values of the biomarkers measured at the respective needle portions N1, N2, ..., Nn.

7 is a view showing a modification of the biometric information measuring sensor according to the present disclosure.

Referring to FIG. 7, referring to FIGS. 1 and 2, a plurality of needle portions N10, N20, N30, and N40 having different lengths may be formed on the bio-information measurement sensor 100. FIG. Here, the first needle portion N10 may have a relatively long length as compared with the other needle portions N20, N30, and N40. The second needle portion N20, the third needle portion N30 and the fourth needle portion N40 may have a length shorter than the length of the first needle portion N10. The second needle portion N20, The lengths of the three needle portions N30 and the fourth needle portion N40 may be the same or substantially the same.

The first needle unit N10 to the fourth needle unit N40 are disposed on the surface SP of the subject SP to measure the biometric information of the subject SP using the bio- The dermal layer SP2 and the subcutaneous layer SP3 of the subject SP with the skin layer SP1. When the same enzyme, that is, the probe biomolecule is attached so that the first needle portion N10 to the fourth needle portion N40 can measure the same biomarker, the position of the subject SP and the surface of the subject SP It is possible to measure the concentration of the biomarker according to the depth from the biomarker. 5, the concentration of the biomarker in the blood vessel of the subject SP is calculated in consideration of the time difference between the measurement results of the first needle portion N10 and the other needle portions N20, N30, and N40 . 6, the concentration of the biomarker in the blood vessel of the subject SP can be calculated in consideration of the measurement depth. Also, the concentration of the biomarker at different positions having the same or similar depth from the surface of the subject SP can be measured using the second needle portion N20 to the fourth needle portion N40. At this time, the concentration of the biomarker measured in the first needle portion N10 and the time difference are used to cause diffusion from the blood vessel portion of the subject SP before the second needle portion N20 to the fourth needle portion N40 The concentration of the biomarker can be predicted.

FIG. 8 is a diagram illustrating transmission of biometric information measured from a subject to the analyzer using the bio-information measuring sensor according to the present disclosure; FIG.

8, an electrical signal measured by the needle portions N1, N2, N3, and N4 by attaching the bio-information measuring sensor 100 to the subject SP can be measured in one region of the bio- And can be transmitted to the terminal unit 200 outside the bioinformation measuring sensor 100 through the formed transmitter 40. 5 shows an example in which the electric signal measured by the bio-information measuring sensor 100 is wirelessly transmitted to the terminal unit 200 through the transmitter 40. However, the present invention is not limited thereto, The terminal unit 200 may be connected by wire to directly transmit electric signals. The terminal unit 200 is an information processing unit such as a mobile device such as a smart phone or a tablet or a PC, and a storage unit. FIG. 7 is a view showing a modification of the biometric information measurement sensor according to the present disclosure.

Referring to FIG. 7, referring to FIGS. 1 and 2, a plurality of needle portions N10, N20, N30, and N40 having different lengths may be formed on the bio-information measurement sensor 100. FIG. Here, the first needle portion N10 may have a relatively long length as compared with the other needle portions N20, N30, and N40. The second needle portion N20, the third needle portion N30 and the fourth needle portion N40 may have a length shorter than the length of the first needle portion N10. The second needle portion N20, The lengths of the three needle portions N30 and the fourth needle portion N40 may be the same or substantially the same.

The first needle unit N10 to the fourth needle unit N40 are disposed on the surface SP of the subject SP to measure the biometric information of the subject SP using the bio- The dermal layer SP2 and the subcutaneous layer SP3 of the subject SP with the skin layer SP1. When the same enzyme, that is, the probe biomolecule is attached so that the first needle portion N10 to the fourth needle portion N40 can measure the same biomarker, the position of the subject SP and the surface of the subject SP It is possible to measure the concentration of the biomarker according to the depth from the biomarker. 5, the concentration of the biomarker in the blood vessel of the subject SP is calculated in consideration of the time difference between the measurement results of the first needle portion N10 and the other needle portions N20, N30, and N40 . 6, the concentration of the biomarker in the blood vessel of the subject SP can be calculated in consideration of the measurement depth. Also, the concentration of the biomarker at different positions having the same or similar depth from the surface of the subject SP can be measured using the second needle portion N20 to the fourth needle portion N40. At this time, the concentration of the biomarker measured in the first needle portion N10 and the time difference are used to cause diffusion from the blood vessel portion of the subject SP before the second needle portion N20 to the fourth needle portion N40 The concentration of the biomarker can be predicted.

FIG. 8 is a diagram illustrating transmission of biometric information measured from a subject to the analyzer using the bio-information measuring sensor according to the present disclosure; FIG.

8, an electrical signal measured by the needle portions N1, N2, N3, and N4 by attaching the bio-information measuring sensor 100 to the subject SP can be measured in one region of the bio- And can be transmitted to the terminal unit 200 outside the bioinformation measuring sensor 100 through the formed transmitter 40. 5 shows an example in which the electric signal measured by the bio-information measuring sensor 100 is wirelessly transmitted to the terminal unit 200 through the transmitter 40. However, the present invention is not limited thereto, The terminal unit 200 may be connected by wire to directly transmit electric signals. The terminal unit 200 may be a device including an information processing unit such as a mobile device such as a smart phone or tablet, a PC, a storage unit, and a display. In addition, the terminal unit 200 may be a wearable device or other electronic device for health care.

9 is a block diagram showing a bio-information measuring sensor according to the present disclosure and a bio-information analyzing system including the same.

9, the electrical signal measured from the bio-information measuring sensor 100 is transmitted to the communication unit 220 of the terminal unit 200, and the transmitted electrical signal is calculated by a predetermined algorithm in the control unit 210 The resultant value for the biometric information of the subject SP can be calculated. The biometric information measured by the biometric information measurement sensor 100 can be stored by the storage unit 240 and compared with the biometric information of the subject SP already stored in the storage unit 240, The amount of change in the biometric information of the subject SP in accordance with the amount of change. The result of the comparison of the biometric information measurement result of the subject SP with the previous measurement result can be output through the display unit 230. [ The biometric information of the subject SP measured by the biometric information measurement sensor 100 can be set in a manner desired by the user through the user interface 250. [

FIG. 10 is a flowchart schematically illustrating a method of measuring biometric information using the bio-information measuring sensor according to the present disclosure.

Referring to FIGS. 9 and 10, first, the bio-information measuring sensor 100 according to the present disclosure is attached to the subject SP (S10). The skin layer SP1 and the subcutaneous layer SP3 may be included depending on the region of the subject SP and the biometric information may be appropriately adjusted according to the body parts of the biomarker and the subject SP to be measured A biometric information measurement sensor including needles N1, N2, N3 and N4 having a predetermined length can be selected. Then, the electric signal measured by the bio-information measuring sensor 100 is transmitted to the communication unit of the external terminal (S20). In the terminal 200, the concentration of the corresponding biomarker is calculated using the bioelectric signal transmitted from the bio-information measuring sensor 100 (S30). The calculated result value may be displayed on the display unit 230 or may be stored in the storage unit 240 (S40).

Many embodiments other than the above-described embodiments are within the scope of the claims of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS The present invention is capable of various modifications and various embodiments, and specific embodiments are illustrated in the drawings and described in detail in the detailed description. It is to be understood, however, that the invention is not to be limited to the specific embodiments, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.

10: Base, 100: Biometric information measuring sensor
22: first electrode portion, 24: second electrode portion
26: third electrode part, 28: fourth electrode part
100: Biometric information measuring sensor,
220, 230, 240, 250, 260, 280: working electrode
222, 232, 242, 252, 262, 282: a counter electrode,
A1, A2, A3, A4, An: a biomarker measurement area,
N1, N2, N3, N4, N10, N20, N30, N40:
SP: subject, SP1: skin layer
SP2: dermal layer, SP3: subcutaneous layer

Claims (24)

A plurality of biomarker measurement regions;
An electrode unit formed on the biomarker measurement area and including a working electrode and a counter electrode spaced apart from the working electrode;
And a needle portion formed on the electrode portion,
Wherein at least some of the needle portions formed in different biomarker measurement regions among the plurality of biomarker measurement regions have different lengths. The method according to claim 1,
Wherein the electrode unit further comprises a reference electrode spaced apart from the working electrode and the counter electrode. The method according to claim 1,
Wherein the counter electrode has a larger surface area than the working electrode. The method of claim 3,
And the nail portion is formed on the working electrode and the counter electrode, respectively. 5. The method of claim 4,
And an enzyme formed on the needle portion formed on the working electrode. The method according to claim 1,
The needle portions formed in the same biomarker measurement region among the plurality of biomarker measurement regions have the same length,
Needle portions formed in different biomarker measurement regions have different lengths. The method according to claim 1,
Wherein the biomarker measurement region includes a first biomarker measurement region having a relatively long needle portion longer than other biomarker measurement regions,
Wherein the lengths of the needle portions of the remaining biomarker measurement regions other than the first biomarker measurement region are substantially equal to each other. The method according to claim 1,
Wherein the needle regions having different lengths have different regions to which enzymes are attached. The method according to claim 1,
Wherein the areas of the areas where the enzymes are attached to the needle parts having different lengths are different from each other. 10. The method of claim 9,
Wherein the number of the unit needles of the needle parts having different lengths is different from that of the needle parts. The method according to claim 1,
Wherein the needle section has a shape of at least one of a circular shape, an elliptical shape, and a polygonal shape. The method according to claim 1,
Wherein the biometric information measuring sensor further comprises a transmitter formed in one area of the biometric information measuring sensor. A plurality of biomarker measurement regions, electrode portions formed in the biomarker measurement region, the electrode portions including a working electrode and a counter electrode spaced apart from the working electrode, and a needle portion formed on the electrode portion, At least some of the needle portions formed in different biomarker measurement regions of the marker measurement region have different lengths; And
And a terminal unit for calculating biometric information of the subject from the electrical signals transmitted from the biometric information measurement sensor. 14. The method of claim 13,
Wherein the electrode unit includes a reference electrode spaced apart from the working electrode and the counter electrode. 14. The method of claim 13,
The needle portions formed in the same biomarker measurement region among the plurality of biomarkers have the same length,
The needle portions formed in different biomarker measurement regions have different lengths. 14. The method of claim 13,
Wherein the needle portions are formed on the working electrode and the counter electrode,
And an enzyme formed on the working electrode. 17. The method of claim 16,
Wherein the lengths of the needle parts differ from each other in the areas where the enzymes are attached. 17. The method of claim 16,
Wherein the areas of the areas to which the enzymes are attached are different from each other in the needle parts having different lengths. 19. The method of claim 18,
Wherein the number of needle units of the needle units having different lengths are different from each other. 14. The method of claim 13,
Wherein the terminal unit comprises: a communication unit for transmitting an electric signal transmitted from the biometric information measurement sensor; And
And a controller for calculating a result of the biometric information of the subject using the electrical signal. A biometric information measuring method using a biometric information measuring sensor,
A biometric information measuring apparatus according to claim 1,
And measuring the concentration of the biomarker corresponding to the electric signal by receiving the electric signal detected from the needle portion inserted into the body of the subject. 22. The method of claim 21,
Wherein the needle portions are formed on the working electrode and the counter electrode, and the enzyme is formed on the working electrode. 23. The method of claim 22,
And calculating concentration values in the blood vessels of the biomarkers by applying weights to the concentration values of the biomarkers calculated from the electrical signals measured from the needle portions. 23. The method of claim 22,
The length of the needle portion in which the enzyme corresponding to the biomarker having a relatively high concentration in the blood vessel of the subject among the biomarkers is disposed is shorter than the length of the needle in which the enzyme corresponding to the relatively low concentration biomarker in the blood vessel of the subject is placed Is shorter than the length of the portion.

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