KR20160111606A - Process management method using process management system for preparing herbal medicine - Google Patents
Process management method using process management system for preparing herbal medicine Download PDFInfo
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- 241000411851 herbal medicine Species 0.000 title claims abstract description 66
- 238000000034 method Methods 0.000 title claims abstract description 61
- 238000007726 management method Methods 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 claims abstract description 154
- 238000000605 extraction Methods 0.000 claims abstract description 110
- 239000003814 drug Substances 0.000 claims abstract description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 39
- 239000011230 binding agent Substances 0.000 claims abstract description 33
- 239000000203 mixture Substances 0.000 claims description 22
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 22
- 238000004821 distillation Methods 0.000 claims description 18
- 229940079593 drug Drugs 0.000 claims description 18
- 235000003599 food sweetener Nutrition 0.000 claims description 17
- 239000003765 sweetening agent Substances 0.000 claims description 17
- 238000004806 packaging method and process Methods 0.000 claims description 15
- 238000009472 formulation Methods 0.000 claims description 14
- 239000000284 extract Substances 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 12
- 230000003287 optical effect Effects 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000010521 absorption reaction Methods 0.000 claims description 10
- 238000012856 packing Methods 0.000 claims description 8
- 238000012795 verification Methods 0.000 claims description 7
- 238000001704 evaporation Methods 0.000 claims description 6
- 230000008020 evaporation Effects 0.000 claims description 6
- 150000002952 aconitine derivatives Chemical class 0.000 claims description 5
- 238000007689 inspection Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 230000005856 abnormality Effects 0.000 claims description 4
- 239000012907 medicinal substance Substances 0.000 claims description 4
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 230000002496 gastric effect Effects 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 235000012907 honey Nutrition 0.000 claims description 3
- 239000002085 irritant Substances 0.000 claims description 3
- 231100000021 irritant Toxicity 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 244000144977 poultry Species 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 239000002562 thickening agent Substances 0.000 claims description 3
- 238000004364 calculation method Methods 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 abstract description 7
- 238000012544 monitoring process Methods 0.000 abstract description 4
- 229930014626 natural product Natural products 0.000 abstract description 4
- 238000011156 evaluation Methods 0.000 abstract description 3
- 230000000704 physical effect Effects 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 238000003070 Statistical process control Methods 0.000 description 4
- 239000008186 active pharmaceutical agent Substances 0.000 description 3
- 229940088679 drug related substance Drugs 0.000 description 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000013022 venting Methods 0.000 description 2
- XFSBVAOIAHNAPC-XTHSEXKGSA-N 16-Ethyl-1alpha,6alpha,19beta-trimethoxy-4-(methoxymethyl)-aconitane-3alpha,8,10alpha,11,18alpha-pentol, 8-acetate 10-benzoate Chemical compound O([C@H]1[C@]2(O)C[C@H]3[C@@]45C6[C@@H]([C@@]([C@H]31)(OC(C)=O)[C@@H](O)[C@@H]2OC)[C@H](OC)[C@@H]4[C@]([C@@H](C[C@@H]5OC)O)(COC)CN6CC)C(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-XTHSEXKGSA-N 0.000 description 1
- XFSBVAOIAHNAPC-UHFFFAOYSA-N Aconitin Natural products CCN1CC(C(CC2OC)O)(COC)C3C(OC)C(C(C45)(OC(C)=O)C(O)C6OC)C1C32C4CC6(O)C5OC(=O)C1=CC=CC=C1 XFSBVAOIAHNAPC-UHFFFAOYSA-N 0.000 description 1
- 229940039750 aconitine Drugs 0.000 description 1
- STDXGNLCJACLFY-UHFFFAOYSA-N aconitine Natural products CCN1CC2(COC)C(O)CC(O)C34C5CC6(O)C(OC)C(O)C(OC(=O)C)(C5C6OC(=O)c7ccccc7)C(C(OC)C23)C14 STDXGNLCJACLFY-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
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- 230000004048 modification Effects 0.000 description 1
- 229940124595 oriental medicine Drugs 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 229940126532 prescription medicine Drugs 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 238000000275 quality assurance Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
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Abstract
Description
The present invention relates to a process for preparing a herbal medicine preparation process using a herbal medicine preparation process management system, and more particularly, it relates to a method for preparing a herbal medicine preparation process by appropriately grasping the physical and chemical properties of natural materials, (Extraction time, extraction water amount, amount of binding agent, etc.) precisely adjusted so that the optimal herbal medicine according to the prescription is prepared and provided to the patient, and the physical and chemical properties of the prepared herbal medicine are grasped DB, it is possible to prepare the same Chinese medicine even if the same condition is prescribed, such as when the same prescription or repeated prescription for the same Chinese medicine or the same patient is made, and the quality of herbal medicine is compared The process of confirming In order to prepare the Chinese medicine, the same Chinese medicine with the same physical characteristics is prepared by using the statistical process control method and the real time monitoring of the Chinese medicine preparation process, so that the same Chinese medicine is prepared and supplied to the patient. The present invention relates to a method of managing a herbal medicine preparation process by a herbal medicine preparation process management system.
Generally, the patient is consulted to the oriental clinic for diagnosis or treatment, and herbal medicine is prepared by herbal medicine.
At this time, the patient's condition varies, and the prescriptions for the various patients are different accordingly.
Recently, a lot of patients who are diagnosed and prescribe them, and a lot of Chinese medicine clinics or other customers who need other Chinese medicine preparations, efficiently register the necessary information for Chinese medicine preparations and conduct joint venting.
There is a need to prepare a precise Chinese medicine so that there is no mistake in the prescription given to the patient in the implementation of such joint venting.
In particular, since Chinese medicine is fundamentally formulated by extracting, crushing, and mixing natural products, a high-level management system is required to ensure the quality equivalence of the final drug product.
For example, in the case of preparing a prescription A, differences in the extraction rates are caused by differences in the preparation method and extraction method. As a result, there is a difference in the extraction ratio of the major active ingredients for each medicament constituting the prescription A, A is a prescription, but in fact all of the other drugs can be prepared. It is important to understand that the effects of aspirin on the cardiovascular and analgesic effects of 10 mg and 100 mg of aspirin are very serious and important.
In addition, a record of the existing registered patient or illness, as well as a record of herbal medicine preparation for the prescription given to them, is used to prepare the same quality Chinese herbal medicine when the same patient or the same symptom is repeatedly prescribed at a later date And it is possible to reduce cost and save time by preparing and managing using existing records and data.
However, it is a fact that there is no professional management system for this purpose.
Therefore, it is necessary to precisely adjust the physical and chemical properties of the raw natural materials and to prepare them in accordance with them (extraction time, extraction water amount, amount of binding agent, etc.) and to grasp the physicochemical properties of the prepared herbal medicine If the same prescription or equivalent condition is prepared afterwards, it is necessary to check whether the quality is maintained through comparison.
Of course, in the case of a general manufacturing industry that mass-produces small items, it is true that these techniques of quality control are generally commercialized. Unusual, however, the Chinese medicine is a system that requires small quantity production of various kinds of products, And management methods.
In order to construct the management system and management method for this purpose, we introduced statistical process control in the Chinese medicine preparation process, and by using the existing records and data as comparative values, it is possible to automate physical property check, It is necessary to ensure the quality assurance of the product.
SUMMARY OF THE INVENTION Accordingly, the present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a method and apparatus for accurately determining physical and chemical characteristics of natural products, (Extraction time, extraction water amount, amount of binding agent, and the like) precisely so that an optimal herbal medicine according to the prescription is prepared and provided to the patient.
It is also an object of the present invention to provide a system and a method for diagnosing a pharmacologically active pharmacologically active pharmacologically acceptable pharmacologically acceptable pharmacologically active pharmacological agent, In addition to the process of confirming that the quality of herbal medicine is kept the same by comparing with the existing DB, the equivalence evaluation is performed by real-time monitoring of the herbal medicine preparation process through the statistical process control method in preparation of Chinese medicine, The same herbal medicine that is guaranteed to be provided to the patient.
In order to achieve the above-mentioned object, a method of managing a herbal medicine preparation process by a herbal medicine preparation process management system according to the present invention is a system for preparing a herbal medicine preparation process, wherein the preparation process management system comprises: Receiving prescription information and dispensing instructions on the type and amount of prescription medicines, formulations, extraction solvents, sweeteners, dosages, and packaging methods; Based on the prescription information, the water absorption of the medicinal material according to the kind of the medicinal material is calculated, and the extraction water amount and the extraction time are automatically calculated by reflecting the amount of the extraction solvent and the sweetener, and the extraction power, Determining a formulation including an automatic calculation of the amount of excipient; Transmitting the preparation prescription information and preparation instructions and the determined preparation method to the process system and preparation work instruction sheet of each preparation step and displaying the same; The preparation process management system prepares the preparation process management system in accordance with the received information and the preparation process, inputs the process content and the result as a QR code for each preparation process step, inputs the finish information of the process to the QR code, Checking whether or not the precise preparation by the preparation method determined in step < RTI ID = 0.0 > The preparation process management system is characterized in that the pharmaceutical preparation prepared in the preparation process is put into an extractor linked with the preparation process management system and the extractor is operated so that the preparation process management system extracts extraction time and output by the preparation method determined in the previous step Information is transmitted to the extractor so that an extraction operation is performed, and after the extraction by the extractor is completed, inspection of physical information of concentration, acidity, salinity, and chromaticity of the extract is performed, and the information is received and stored; Formulating the extract into any one of a tablet, a pill, a solid, a thickener, a powder, a granule, a tablet or a capsule; Packaging the herbal medicine with the correct dosage and packaging method according to the preparation instructions; Confirming that the packaging is completed in the same manner as the preparation instructions for the packaged herbal medicine; And packaging and dispensing the validated herbal medicine.
In the present invention, when the extraction time is longer than 75 minutes, the preparation method is generally used. If the extraction time is 45 minutes to 75 minutes, it is general. If the extraction time is less than 15 minutes, .
In the present invention, the determination of the water absorption degree, extraction power, extraction water amount, extraction time,
1. Water absorption of the medicinal substance = classification factor * (amount of water + dry drug discretion - wet drug discretion)
However, the classification coefficients were classified into two groups: seeds (1.5), rootstocks (1.3), cutaneous (1.2), outcrops (1.1), furrows (1.1), poultry (1.3).
2. Extracting power is 3.4 ~ 3.6kwh in case of containing more than 20% of minerals in the whole composition, 50% or more of near apices and aconitine alkaloid in total composition, 3.4 ~ 3.6kwh in whole composition, 0.3 to 0.4 kwh in the case of 10% or more of the flow, 0.8 to 1.0 kwh in the case of 10% or more of the total flow, and 1.7 to 1.9 kwh otherwise.
3. Extraction water =
+ Evaporation i
+ (Pack number +3) * Pack capacity
+ Addition amount of distillation (5000 ~ 8000) * Distillation variable i
- Amount of sweeteners added
However, evaporation amount = 187.5 * thermal power + 543.75
Amount of sweetener added = (0.85 * 1 pack capacity * total packs) / sweetener sugar content
Distillation variable: distillation extraction = 1, non-distillation extraction = 0
4. Extraction time = 2/3 * (Extraction water / 1000-5) + 45 + alpha
However, α is a special drug extraction coefficient,
If a drug containing an Aconitine Alkaloid is included: 1,
If gastrointestinal irritant medicines (Supervision, Won, Correspondence) are included: 0.5,
When distillation extraction is applied: Set to 1.5.
5. Binder Consumption
=
However, when the binder use factor is honey: binder use factor = 1/2 * circle diameter + 0.05,
When the binder use factor is a starch paste: binder use factor = 3/10 * diameter of the ring + 0.06,
When the binder use factor is a purified water: binder use factor = 3/5 * diameter of the ring + 0.06,
.
In the present invention, the preparation process management system receives the QR code information attached to each pharmaceutical preparation at each preparation process step to check whether it coincides with the pharmaceutical preparation in the prescription information of the work instruction sheet, The control unit 10 receives the weight information of the pharmaceutical preparation from the work instruction sheet and checks whether or not it matches the prescription amount of the pharmaceutical preparation in the prescription information of the work instruction sheet. .
In the present invention, the error range of the prescription amount of the pharmaceutical preparation is set to be within 5%.
In the present invention, the preparation process management system transmits extraction information such as extraction power, extraction time, extraction water amount, extraction method, sweetener amount, and ethanol addition amount to the user, and when extraction is completed by the extraction method using the information The extraction control unit receives the extraction completion signal from the extraction unit connected to the process management system server wirelessly or by wire, and extracts 4cc of the extraction optical density sensor, the refractive optical salinity sensor, the acidity sensor and the optical chromaticity sensor, 1cc, the information on concentration, salinity, acidity, and chromaticity measured by each sensor provided in the extractor is transmitted and stored, and the newly measured value is stored in the same existing prescription By calculating the average and standard deviation of each stored value, the probability density If within a certain range, and calculates the number of newly measured value, characterized in that, by sending the information and the deviation is not equal when there is outside the range, and transmits the information to manage the accuracy equal to that of the formulation.
In the present invention, the dispensing process management system automatically outputs the coupon delivery electronic invoice according to the address information of the recipient of the work instruction sheet to output the invoice, and reads the bar code information of the invoice before dispatch to the scanner, And information indicating that there is no abnormality is transmitted. In case of discrepancy, information indicating that the dispatch is impossible is transmitted so as to manage the accuracy of dispatch.
In the present invention, the preparation process management system is characterized by generating a preparation operation log, a formulating operation log, a verification operation and a packing operation log.
The method of preparing the herbal medicine preparation process by the herbal medicine preparation process management system according to the present invention can accurately grasp the physicochemical characteristics of the natural product which is the raw material of the herbal medicine and provide the optimal preparation method for each of various prescriptions And an extraction method (extraction time, extraction water amount, amount of binding agent, etc.) are precisely adjusted, so that an optimal Chinese medicine suitable for a prescription is prepared and provided to a patient.
In addition, the present invention can identify the physical and chemical properties of the herbal medicine which has been prepared, and make it into a database. Thus, even when the herbal preparations of the same condition are to be made in the same prescription or repeated prescriptions for the same oriental medicine or the same patient, , It is confirmed that the quality of herbal medicine is kept the same. In addition, by performing statistical process control method for the preparation of herbal medicine, the equivalence evaluation is performed by real-time monitoring of the herbal medicine preparation process. It is effective to prepare the same herbal medicine to be provided to the patient.
1 is a view illustrating a method of managing a herbal medicine preparation process by a herbal medicine preparation process management system according to the present invention,
BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, preferred embodiments of a method of preparing a herbal medicine preparation process by a herbal medicine preparation process management system according to the present invention will be described in detail with reference to the accompanying drawings.
1 is a view illustrating a method of managing a herbal medicine preparation process by the herbal medicine preparation process management system according to the present invention.
As shown in the figure, the method of managing a herbal medicine preparation process according to the herbal medicine preparation process management system according to the present invention includes a step (S100) of receiving prescription information and preparation instructions, a step S200 of determining a preparation method according to prescription information of a pharmaceutical preparation, (Step S300), checking whether the preparation according to the preparation method determined according to each preparation process step (S400) is performed along with the preparation according to the preparation method (S400), extracting operation by the extractor and extracting (S 500) of inspecting and storing physical information such as concentration, acidity, salinity, acidity and the like (S500), formulating the extract into a selected one of the formulations (S600), preparing the formulated herbal medicine (S700), a step of inspecting the packaged herbal medicine according to the preparation instructions (S800), a step of packaging and inspecting the herbal medicine And it comprises a step (S900) to.
The step (S100) of receiving the prescription information and the prescription instructions may include a step of determining whether the prescription information and the prescription instructions are included in the prescription information based on basic information such as the name of the medical institution requesting prescription, , An extracting solvent using water or an ethanol solution, a sweetener having a brix, a dose per pack or pack in the case of tablet, a dosage such as a single dose (g) in the case of other formulations, Means receiving information or instructions on the packaging method, such as the type of pack, package unit, box type, and package unit in case of other formulations.
Next, in the step S200 of determining a preparation method according to the prescription information of the pharmaceutical preparation, the water absorption degree of the medicinal material according to the kind of the medicinal material is calculated through the received prescription information, and the amount of extracted water And calculating the extraction time automatically, and automatically calculating the amount of binding agent and excipient according to the extraction power and formulation.
Herein, the following definitions will be described in detail in determining the water absorption degree, extraction power, extraction water amount, extraction time and amount of the binding agent of the medicinal substance.
First, the water absorption of the medicinal product is determined by the following equation.
Water absorption of the medicinal substance = classification factor * (amount of water + dry drug discretion - wet drug discretion)
However, the classification coefficients were classified into two groups: seeds (1.5), rootstocks (1.3), cutaneous (1.2), outcrops (1.1), furrows (1.1), poultry (1.3).
Next, the extraction power is set to 3.4 to 3.6 kwh in the case where the extracting power is 20% or more of the total constituents, the case where the near-end diameter is 50% or more of the whole constitution, and the case where the drug containing alkaline aconitine is contained, In the case of 10% or more of the whole composition, it is determined as 0.3 to 0.4 kwh. In case of 10% or more of the whole composition, 0.8 to 1.0 kwh is preferably set.
The following is the definition of the extraction water quantity.
Extraction water =
+ Evaporation i
+ (Pack number +3) * Pack capacity
+ Addition amount of distillation (5000 ~ 8000) * Distillation variable i
- Amount of sweeteners added
However, evaporation amount = 187.5 * thermal power + 543.75
Amount of sweetener added = (0.85 * 1 pack capacity * total packs) / sweetener sugar content
Distillation parameters: distillation = 1, not = distillation = 0.
The following is the definition of the extraction time.
Extraction time = 2/3 * (extraction water / 1000 - 5) + 45 +
At this time, α: a special medicinal material extraction coefficient,
If a drug containing an Aconitine Alkaloid is included: 1,
If gastrointestinal irritant medicines (Supervision, Won, Correspondence) are included: 0.5,
When distillation extraction is applied: Set to 1.5.
Next is the amount of binder used.
Binder usage
=
.
However, when the binder use factor is honey: binder use factor = 1/2 * circle diameter + 0.05,
When the binder use factor is a starch paste: binder use factor = 3/10 * diameter of the ring + 0.06,
When the binder use factor is a purified water: binder use factor = 3/5 * diameter of the ring + 0.06,
As an example.
In addition, the drug discretion varies depending on each drug substance, and in particular, the disintegration loss coefficient depending on the drug substance is also determined according to a database (DB) sorted by each drug substance. In the present invention, a database for the frictional coefficient of the medicament is constructed and used for 890 or more kinds of medicines.
Particularly, in the preparation method, when the extraction time is longer than 75 minutes, it is promoted, when the extraction time is 45 minutes to 75 minutes, it is general, when the extraction time is 15 minutes or less, when the extraction time is unnecessary, .
At this time, the preparation method of pharmaceuticals is classified into propellant, general medicine, post-infusion, and post-infusion.
The following is a step S300 of the preparation process management system, which transmits the preparation preparation information and preparation instructions and the determined preparation method to the process system and the preparation work instruction sheet of each preparation step and displays it (S300).
Next, in step S400, it is determined whether the preparation according to the preparation method according to the preparation method and the preparation according to the preparation method determined in each preparation step are performed. The preparation process management system prepares it in accordance with the received information and the preparation method, The process contents and results are inputted into the QR code and the completion information of the process is inputted into the QR code to check whether the precise preparation according to the preparation method determined in the previous steps has been performed.
Particularly, the preparation process management system receives the QR code information attached to each pharmaceutical preparation at each preparation process step to check whether it coincides with the pharmaceutical preparation in the prescription information of the work instruction sheet, and sends a warning if it does not match. The weight information is received, and it is checked whether or not the weight information matches the prescription amount of the pharmaceutical preparation in the prescription information of the work instruction sheet. If the weight information is out of the error range, a warning is sent and the preparation is checked according to the preparation method.
Here, the error range of the prescribed amount of the pharmaceutical preparation is preferably set to be within 5%.
Next, a step S500 of inspecting and storing physical information such as concentration, acidity, salinity, acidity and the like after the extraction operation by the extractor (S500) is performed by the preparation process control system by using the preparation preparation prepared in the preparation process, And the extracting operation is performed by sending the extracting information such as the extraction time and the output to the extracting device by the preparation method determined in the previous step while the extracting device is operated while the extracting device is operated, After the extraction by the extractor is completed, the extract is inspected for physical information of concentration, acidity, salinity and chromaticity, and the information is transmitted and stored.
In detail, the preparation process management system transmits extraction information such as extraction power, extraction time, extraction water amount, extraction method, sweetener amount, and ethanol amount to the extractor, and puts the preparation agent into an extractor to operate the extractor. Thereafter, when extraction is completed in the extractor, the preparation process management system transmits comparison operation information for comparison with the result, monitors the concentration, pH and chromaticity of the extract in real time, and stores the compared measurement information.
In this case, it is preferable that the concentration is measured using a refraction type optical density sensor, the acidity is measured using an acidity sensor, and the chromaticity is measured using an optical chromaticity sensor.
More specifically, the preparation process management system receives the information of the QR code attached to each pharmaceutical preparation at each of the preparation process steps and checks whether it coincides with the pharmaceutical preparation in the prescription information of the work instruction sheet. At this time, So that the accuracy of the preparation is managed.
The preparation process control system receives the weight information of the pharmaceutical preparation from the electronic balance and checks whether or not it matches the prescribed amount of the pharmaceutical preparation in the prescription information of the work instruction sheet. At this time, if the information exceeds the error range, Manage the accuracy of the preparation. Here, the error range of the prescribed amount of the pharmaceutical preparation is preferably within 5%.
And, the preparation process management system makes it possible to check the preparation accuracy according to the preparation method.
On the other hand, as a method of managing the accuracy of formulation, extraction information such as extraction power, extraction time, extraction water amount, extraction method, sweetener amount, and ethanol addition amount is transmitted by the preparation process management system, So that extraction is completed by the extraction method.
Upon completion of the extraction, an extracting completion signal is received from the extracting apparatus connected to the preparation process management system via a wireless or wired connection, and a refractive optical density sensor, a refractive optical salinity sensor, an acidity sensor and an optical chromaticity sensor And 4 cc of the extract solution is injected into each of 1 cc.
The preparation process management system receives and stores information on the concentration, salinity, acidity, and chromaticity measured by each sensor installed in the extractor when a predetermined amount of 1cc is injected from the extractor according to the sent operation information.
At the same time, store the newly measured values for the same existing prescription (ie, the same type and amount of medicinal material and the same extraction method).
The average and standard deviation of each stored concentration, acidity, salinity, and chromaticity values are calculated, the probability density function is calculated, and compared with the existing formulation data for equality verification, a range of newly measured values (Preferably, an average of ± 3.5 * standard deviation), and when information is out of the range, information indicating that the information is not equivalent and the deviation (average-newly measured value) Manage accuracy.
Next, the step of formulating the extract into any one of a tablet, a pill, a tablet, a thickener, a powder, a granule, a tablet, and a capsule (S600).
(S700) including packing the formulated herbal medicine in accordance with the basic information and preparation instructions, and packaging the herbal medicine in a packing method, wherein the packaged herbal medicine is dispensed with instructions for preparation, that is, And inspecting whether or not the packaging has been completed according to the type of pack (S800). At this time, the inspection step confirms whether or not the result is a work instruction sheet.
Finally, the step S900 includes packing and delivering the inspected Chinese medicine.
It is possible to check whether the information of the work instruction sheet matches the invoice and to receive the invoice history information such as the dispatch collection delivery of the dispatcher to track the delivery and check whether the work created in the work log is incomplete or not, And verifies whether it is.
Particularly, the dispensing process management system automatically outputs the coupon sending electronic invoice according to the address information of the recipient of the work instruction sheet to output the invoice, and reads the bar code information of the invoice before dispatch to the scanner, And information indicating that there is no abnormality is transmitted. In case of discrepancy, information indicating that the product is unavailable is transmitted so that the accuracy of the product is controlled.
Meanwhile, in the preparation process management system, when an abnormality occurs in the preparation step, the formulating step, the inspection step, and the verification of the invoice conformity of the packaging, the system notifies the operator of the preparation process To be more complete.
When the equivalence is confirmed by the result comparison in the formulation step, the next step is performed. However, if the equivalence is not confirmed, a notification signal is generated so that the process control of the worker is completed.
Further, in the above-described one-shot preparation process management system, preparatory work log, formulated work log, verification work and packing work log are generated.
The preparation operation log is classified according to the extraction method according to the extraction method, and the formulation operation log is composed of a tableting operation log for extracting solvent, extraction time, extraction power and the like, and a tablet, And so on.
The inspection log records the basic information, the number of packs, the pack capacity, the pack type, etc., and the packing log book records the packing material, the packaging unit, the turbidity verification, the presence of foreign matter, and the equivalence verification. That is, it is preferable that the production of the working log is recorded in a comprehensive manner for the whole process.
The terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary terms and the inventor may appropriately define the concept of the term in order to best describe its invention It should be construed as meaning and concept consistent with the technical idea of the present invention.
Therefore, the configurations shown in the drawings and the embodiments described herein are merely the most preferred embodiments of the present invention, and are not intended to represent all of the technical ideas of the present invention. Therefore, It is to be understood that equivalents and modifications are possible.
DESCRIPTION OF THE REFERENCE NUMERALS
Claims (8)
The preparation process management system is a system for preparing pharmaceuticals from the medical institution requesting prescription, basic information such as the name of the medical institution, the name of the patient, preparation date, prescription information and preparation instructions Receiving an item;
Based on the prescription information, the water absorption of the medicinal material according to the kind of the medicinal material is calculated, and the extraction water amount and the extraction time are automatically calculated by reflecting the amount of the extraction solvent and the sweetener, and the extraction power, Determining a formulation including an automatic calculation of the amount of excipient;
Transmitting the preparation prescription information and preparation instructions and the determined preparation method to the process system and preparation work instruction sheet of each preparation step and displaying the same;
The preparation process management system prepares the preparation process management system in accordance with the received information and the preparation process, inputs the process content and the result as a QR code for each preparation process step, inputs the finish information of the process to the QR code, Checking whether or not the precise preparation by the preparation method determined in step < RTI ID = 0.0 >
The preparation process management system is characterized in that the pharmaceutical preparation prepared in the preparation process is put into an extractor linked with the preparation process management system and the extractor is operated so that the preparation process management system extracts extraction time and output by the preparation method determined in the previous step Information is transmitted to the extractor so that an extraction operation is performed, and after the extraction by the extractor is completed, inspection of physical information of concentration, acidity, salinity, and chromaticity of the extract is performed, and the information is received and stored;
Formulating the extract into any one of a tablet, a pill, a solid, a thickener, a powder, a granule, a tablet or a capsule;
Packaging the herbal medicine with the correct dosage and packaging method according to the preparation instructions;
Confirming that the packaging is completed in the same manner as the preparation instructions for the packaged herbal medicine; And
And packaging and dispensing the verified herbal medicine. The method according to claim 1,
The preparation method is characterized in that when the extraction time is 75 minutes or longer, the propagation time is 45 minutes to 75 minutes, the extraction time is 15 minutes or less, and when the extraction time is unnecessary, A method for the preparation of herbal medicine by the herbal medicine preparation process management system.
The determination of the water absorption, extraction power, extraction water amount, extraction time, and amount of binding agent of the medicinal material is defined as follows.
1. Water absorption of the medicinal substance = classification factor * (amount of water + dry drug discretion - wet drug discretion)
However, the classification coefficients were classified into two groups: seeds (1.5), rootstocks (1.3), cutaneous (1.2), outcrops (1.1), furrows (1.1), poultry (1.3).
2. Extracting power is 3.4 ~ 3.6kwh in case of containing more than 20% of minerals in the whole composition, 50% or more of near apices and aconitine alkaloid in total composition, 3.4 ~ 3.6kwh in whole composition, 0.3 to 0.4 kwh in the case of 10% or more of the flow, 0.8 to 1.0 kwh in the case of 10% or more of the total flow, and 1.7 to 1.9 kwh otherwise.
3. Extraction water =
+ Evaporation i
+ (Pack number +3) * Pack capacity
+ Addition amount of distillation (5000 ~ 8000) * Distillation variable i
- Amount of sweeteners added
However, evaporation amount = 187.5 * thermal power + 543.75
Amount of sweetener added = (0.85 * 1 pack capacity * total packs) / sweetener sugar content
Distillation variable: distillation extraction = 1, non-distillation extraction = 0
4. Extraction time = 2/3 * (Extraction water / 1000-5) + 45 + alpha
However, α is a special drug extraction coefficient,
If a drug containing an Aconitine Alkaloid is included: 1,
If gastrointestinal irritant medicines (Supervision, Won, Correspondence) are included: 0.5,
When distillation extraction is applied: Set to 1.5.
5. Binder Consumption
=
However, when the binder use factor is honey: binder use factor = 1/2 * circle diameter + 0.05,
When the binder use factor is a starch paste: binder use factor = 3/10 * diameter of the ring + 0.06,
When the binder use factor is a purified water: binder use factor = 3/5 * diameter of the ring + 0.06,
Wherein the method comprises the steps of:
The preparation process management system receives the QR code information attached to each pharmaceutical preparation at each preparation process step to check whether it coincides with the pharmaceutical preparations contained in the prescription information of the work instruction sheet and sends a warning if not, , And a warning is sent when an error is out of the error range, and it is checked whether the preparation is appropriate for the preparation method so as to manage the accuracy of the preparation. A method of management of herbal medicine preparation process by management system.
Wherein the error of the prescription amount of the pharmaceutical preparation is within 5%.
The preparation process management system transmits extraction information such as extraction power, extraction time, extraction water amount, extraction method, sweetener amount, and ethanol addition amount to the user, and when extraction is completed by the information, And the extractive optical signal is received from an extractor connected wirelessly or by wire, and 4cc of the extractive liquid is injected into each of the refraction type optical density sensor, refraction type optical salinity sensor, acidity sensor and optical chromaticity sensor provided in the extractor Salinity, acidity, and chromaticity measured by the respective sensors installed in the extractor when the operation information is transmitted from the extractor, and stores the newly measured values in the same existing prescription, Calculate the probability density function by calculating the mean and standard deviation of When the measured value is within a certain range, information indicating that the measured value is equivalent is transmitted, and when the measured value is out of the range, information indicating that the measured value is not equal and deviation is transmitted to manage the accuracy of the formulation. How to manage herbal medicine manufacturing process.
The dispensing process management system automatically outputs the dispatch electronic invoice according to the address information of the recipient of the work instruction sheet to output the invoice, and reads the bar code information of the invoice before dispatch to the scanner to match the dispensing information of the work instruction sheet And information indicating that there is no abnormality is sent. In case of inconsistency, information indicating that the product is unavailable is transmitted so that the accuracy of the product is managed. In the herbal medicine preparation process management system, How to manage the preparation process.
Wherein the preparation process management system generates a preparation process log, a formulation log, a verification process, and a packing log.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108513633A (en) * | 2017-09-01 | 2018-09-07 | 深圳市中瑞远博软件信息有限公司 | A kind of extracts of Chinese herbal medicine concentration intelligent control system |
| KR102095230B1 (en) * | 2019-07-26 | 2020-03-31 | 구태훈 | Integrated management system of medicinal decoction outside of the hospital |
| KR102095752B1 (en) * | 2019-07-26 | 2020-04-01 | 구태훈 | System for managing integrated quality for a herbal medicine |
| KR20200056005A (en) * | 2018-11-14 | 2020-05-22 | 김헌성 | Medicinal decoctions method for based on ICT |
| KR20210009637A (en) * | 2019-07-17 | 2021-01-27 | 주식회사 케이엘아이에스 | Process control method for preparing herbal medicine |
| KR20210047586A (en) * | 2019-10-22 | 2021-04-30 | 주식회사 케이엘아이에스 | Auto control system of vessel for extracting herb medicine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2009037382A (en) * | 2007-08-01 | 2009-02-19 | Atsumi Tec:Kk | System for monitoring manufacturing line |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108513633A (en) * | 2017-09-01 | 2018-09-07 | 深圳市中瑞远博软件信息有限公司 | A kind of extracts of Chinese herbal medicine concentration intelligent control system |
| WO2019041293A1 (en) * | 2017-09-01 | 2019-03-07 | 深圳市中瑞远博软件信息有限公司 | Intelligent control system for concentrating chinese herbal medicine extract |
| KR20200056005A (en) * | 2018-11-14 | 2020-05-22 | 김헌성 | Medicinal decoctions method for based on ICT |
| KR20210009637A (en) * | 2019-07-17 | 2021-01-27 | 주식회사 케이엘아이에스 | Process control method for preparing herbal medicine |
| KR102095230B1 (en) * | 2019-07-26 | 2020-03-31 | 구태훈 | Integrated management system of medicinal decoction outside of the hospital |
| KR102095752B1 (en) * | 2019-07-26 | 2020-04-01 | 구태훈 | System for managing integrated quality for a herbal medicine |
| KR20210047586A (en) * | 2019-10-22 | 2021-04-30 | 주식회사 케이엘아이에스 | Auto control system of vessel for extracting herb medicine |
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