KR20160086672A - Perfusion device for organ harvest surgery - Google Patents

Abstract

The present invention relates to an intraperitoneal organ perfusion device for an organ enucleation surgery. A perfusion step of feeding a preserving liquid in the artery of an organ donor to stably enucleating his/her organ can be easily and rapidly performed, and an organ can be maintained without being damaged for several hours in the preserving liquid. The intraperitoneal organ perfusion device comprises: an intubation tube unit formed in a tube shape having a feeding hole defined therein, inserted in the left aorta femoralis of the inguinal region of the human body, and mounted on the directly lower part of the diaphragm of the main artery; a blocking unit for blocking the arterial tube path by a first balloon and a second balloon which are respectively mounted on the front end and the middle part of the intubation tube and expanded by feeding a saline solution; a catheter for supplying a saline solution to the first balloon and the second balloon through the intubation tube; and a preserving liquid fed from the outside of the human body into an organ to be enucleated through the intubation tube and the arterial tube path blocked by the intubation tube. According to the present invention, peeling and friction of the main artery under the diaphragm, peeling of the abdominal main artery for inserting a catheter, and friction of both side iliac main arteries are not needed. Compared to a conventional surgery, according to the present invention, a danger is reduced just by exposing one side aorta femoralis and inserting a catheter in the exposed aorta femoralis. A danger is reduced, so a surgery can be rapidly operated in a safe state.

Description

[0001] Description [0002] Perfusion device for organ harvest surgery [0003]

The present invention relates to a long-term perfusion process in which a preservative is injected into the aorta of an organ donor to extract organs of a organ donor in an intact state, and relates to an intraperitoneal long-term perfusion apparatus for organ harvesting surgery, .

For organ transplant surgery, it is necessary to take the donor's organs into a state of being able to donate to a healthy condition. Types of donors include bio-donors and brain death donors. Bio-donors refer to living persons. Brain death donors refer to persons who have fallen into brain death. In the case of brain death donors, it is common to collect several organs available to the body at once.

The organs most commonly used in brain death donors are the kidneys and liver, and the pancreas and small intestine can also be used.

Successful organ harvesting requires two steps before the donor can stop the heart.

First, blood in the organs to be used should be quickly washed away with cold preservation fluid, and blood vessels in organs should be filled with preservative to prevent blood clots from forming in the capillaries.

Second, during the injection of the preserving liquid, the body cavity should be filled with ice to lower the body temperature so that the organs can be transformed into the low temperature ecology within a short period of time.

The preservation liquid is a liquid specially designed for organ transplantation surgery, and the blood in the organs is washed out with this liquid, and when the organ is stored in this liquid, the organ can be maintained for several hours without being damaged by the cell.

The process of injecting this preserving fluid into the artery supplying the blood to the organ in a short period of time is referred to as " perfusion ", and the operation procedure of the current perfusion is as shown in Fig. After the catheter (21) is inserted into the abdominal aorta above the iliac artery, the left and right iliac arteries are ligated and the aorta under the diaphragm is ligated with a forceps (30).

Then, after the storage liquid L contained in the pouch is injected into the abdominal aorta at a high speed through the catheter 21, a hole is made in the inferior vein located on the right side of the aorta so that all the blood in the organ donor body is discharged, The renal artery and bilateral renal arteries are infused with perfusion fluid, which allows the blood of the organs, usually the liver, kidneys, and small intestine, to be used, and to fill the bloodstream with perfusion fluid.

However, this operation becomes a very difficult process in some cases. In the case of brain-dead patients, the entire brain has lost its physiological activity, and the patient is progressing slowly to a cardiac condition with a medical death, so that the vital signs are often very unstable.

Such conventional "perfusion" surgery requires various steps such as detachment of the diaphragmatic artery, ligation of the abdominal aorta, ligation of the abdominal aorta for catheter insertion, and ligation of bilateral perforation arteries, and there is a risk that massive hemorrhage may occur.

In addition, successful long-term extraction requires all surgical procedures required for "perfusion" to be completed while maintaining a constant blood pressure and oxygen saturation prior to the "perfusion" procedure, which may require long operative procedures or unexpected bleeding, The quality of the organ is deteriorated and the result of the transplantation operation is not good.

It is an object of the present invention to finish all the surgical procedures necessary for " perfusion " quickly and easily while maintaining a state of maintaining a constant blood pressure and oxygen saturation before " perfusion "

The purpose of the present invention is to ligate thin blood vessels that approach and branch to the abdominal aorta deeply located in the abdominal cavity during perfusion, to insert a catheter into the aorta, and to ligature the aorta of the right lower diaphragm with a forceps And thus it is possible to omit the process of peeling off.

In order to achieve the above-mentioned object, the apparatus for endovascular peritoneal organs for organ harvesting according to the present invention has a tubular shape having an inlet hole therein, and is inserted into the left femoral artery of the inguinal region of the body, An insertion tube portion; A blocking unit installed at an intermediate position between the distal end of the insertion tube and the first balloon and the second balloon expanded by the infusion of saline to prevent unnecessary leakage of the preservation liquid; A catheter through which the saline solution is supplied to each of the first balloon and the second balloon through the tube; A connector through which the preserving liquid can be injected from the outside of the body into the insertion tube; And the like.

In the configuration provided so that the object of the present invention can be sufficiently achieved, the insertion tube portion includes: respective fixing grooves formed so that the first balloon and the second balloon are installed; And a discharge hole through which the outer surface of the tube between the fixing grooves is cut so that the storage liquid to be injected is discharged into the aorta.

The first balloon and the second balloon of the blocking portion are fixed to the inner diameter of the first balloon and the second balloon and fastened and fixed to the fixing groove of the tube, And a coupling tube projecting from the tightening fixture and connected to the catheter through a through hole of the fixing groove.

In the configuration in which the object of the present invention is sufficiently achieved, the discharge hole is formed by piercing the outer surface of the tube, and is formed at the position of the celiac artery, the superior mesenteric artery, and the renal artery origin of the aorta.

In the configuration provided so that the object of the present invention is sufficiently achieved, the first balloon provided in the tube of the occlusion unit is inflated at the position just under the diaphragm at the insertion tube portion, and the second balloon is inflated at the position in the chamber just above the iliac artery .

In the configuration provided so that the object of the present invention is sufficiently achieved, the fastening fastening portion of the first and second balloons has a smaller diameter than the fastening hole diameter formed in the insertion tube portion, and is formed of a stretchable material so that the fastening fastening portion is tightly fixed .

According to the present invention, there is no need for a conventional method, namely, separation and ligation of the lower diaphragmatic artery, ligation of the abdominal aorta for insertion of the catheter, and ligation of the bilateral iliac arteries. Exposure of one femoral artery, Insertion alone has the same effect as the existing surgery and provides an advantage of speeding up the operation.

In particular, instead of the abdominal aorta, which is deeply located in the abdominal cavity and large in diameter, it is located directly under the skin of the inguinal region and approaches the femoral artery which is easy to handle. Advantages are provided.

FIG. 1 is a view showing a perfusion process of a conventional organ extraction surgery. FIG.
FIG. 2 is a state diagram showing a configuration of an intra-abdominal intragastric perfusion device for organ harvesting surgery of the present invention. FIG.
FIG. 3 is a state in which a long-term perfusion device applying the embodiment of the present invention is applied to the aorta. FIG.
FIG. 4 is a cross-sectional view showing an inflated state of the balloon of the obstruction in the organ perfusion device according to the present invention. FIG.

The following detailed description of the invention refers to the accompanying drawings, which illustrate, by way of illustration, specific embodiments in which the invention may be practiced. These embodiments are described in sufficient detail to enable those skilled in the art to practice the invention. It should be understood that the various embodiments of the present invention are different, but need not be mutually exclusive. For example, certain features, structures, and characteristics described herein may be implemented in other embodiments without departing from the spirit and scope of the invention in connection with one embodiment.

It is also to be understood that the position or arrangement of the individual components within each disclosed embodiment may be varied without departing from the spirit and scope of the invention.

The following detailed description is, therefore, not to be taken in a limiting sense, and the scope of the present invention is to be limited only by the appended claims, along with the full scope of equivalents to which such claims are entitled, if properly explained.

In the drawings, like reference numerals refer to the same or similar functions throughout the several views, and length and area, thickness, and the like may be exaggerated for convenience.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings, so that those skilled in the art can easily carry out the present invention.

FIG. 2 is a view showing a configuration of an intra-abdominal intragastric perfusion apparatus for organ harvesting according to the present invention. The present invention is an apparatus for facilitating a "perfusion" process in a long-term extraction operation of a brain death donor,

One end of the hose-shaped insertion tube 100, which is preferably made of a silicone material free from harm to the human body, is a first balloon 210 which is inflated with infusion of saline solution to block the end, 100 and the opposite end of the insertion tube 100 is connected to a connection port 136 for connecting the storage liquid L to be injected into the aorta A. The second balloon 250 is surrounded by an outer diameter of the insertion tube 100, And a catheter 300 made of a high-quality material necessary for inflating the first balloon 210 and the second balloon 250 to prevent the preservation liquid from leaking through an unnecessary path when the preservation liquid L is injected.

FIG. 3 is a state in which a long-term perfusion device according to an embodiment of the present invention is applied to an aorta. FIG. 3 is a block diagram illustrating the configuration of an embodiment of the present invention.

The insertion tube 100 inserted into the aorta of a patient to be organs to be extracted has a hose shape and is inserted into the femoral artery from the inguinal position of the body and is mounted to the lower portion of the diaphragm of the aorta, An inflow hole 107 having a passage is formed.

The insertion tube part 100 includes an induction part 130 for allowing the liquid injected into the inflow hole 107 to be discharged to the outside and an injection part 110 connected to the preservation liquid L and saline solution at the inguinal part of the body, .

The guiding part 130 provided in the insertion tube part 100 is provided with a first balloon 210 and a second balloon 210 which are installed at the distal end and the intermediate position to block unnecessary leakage of the preservative L from the aorta A during inflation, 250 are provided on the upper and lower sides of the opening.

4 is a sectional view showing a state in which the balloon of the blocking portion is inflated in the organ perfusion device to which the present invention is applied. In the guide portion 130 of the insertion tube portion 100, the first balloon 210 and the second balloon 250, And a through hole 146 is formed in the fixing groove 140 to connect the balloon 210 and the catheter 300 to each other.

A discharge hole 112 is formed in the inflow portion 130 between the fixing grooves 140 so that the storage liquid L injected through the connection port 136 is discharged into the aorta A.

When the first balloon 210 is positioned directly beneath the diaphragm, the discharge hole 112 is formed in the celiac artery, the superior mesenteric artery, And puncture the origin of the renal artery.

And is formed by perforating the outer surface located between the position of the right coronary artery and the position of the celiac artery in the blocked arterial line (A).

This is to shorten the travel distance so that the preservation fluid (L) can flow rapidly into the celiac artery, the superior mesenteric artery, the left renal artery, and the right renal artery.

In forming the insertion tube portion 100, it is preferable that the insertion tube portion 100 is formed of a silicone material free from any harm to the human body.

The first balloon 210 and the second balloon 250 of the blocking portion 200 are fixed to the inner diameters of the first balloon 210 and the second balloon 250 and are fixed to the fixing groove of the insertion tube portion 100 And the tightening fixing portions 213 and 253 are fastened and fixed to the catheter 300 through the through holes 146 of the fixing groove 140 So that the tube 220 is formed by protruding.

The tightening fixing portions 213 and 253 of the first and second balloons 210 and 250 are formed to have a diameter smaller than the diameter of the fixing groove 140 formed in the guide portion 130 of the insertion tube portion 100.

The first and second balloons 210 and 250 are formed of elastic materials so as to be tightly fixed to the fixing grooves 140 by the elasticity of the tightening fixing portions 213 and 253 when the tightening fixing portions 213 and 253 of the first and second balloons 210 and 250 are formed.

The insertion tube part 100 has a connecting cap 136 connected to a supply pipe 410 formed in a pouch 400 of a storage liquid and a connecting cap 310 for supplying saline to the periphery of the connecting cap 136. [ The catheter 300 is provided.

According to the present invention having the above-described constitution, in carrying out the "perfusion" surgery for extracting organs from organ donors in a short period of time, If it is determined that donation is appropriate, prepare the ice and approach the femoral artery, which is located in the inguinal region and easily touched by hand (without approaching the aorta deeply located in the abdomen as in the conventional method).

The femoral artery in the inguinal region of the body is selected in a state in which the first and second balloons 210 and 250 of the insertion tube portion 100 of the present invention are shrunk and the insertion tube portion 100 is inserted into the femoral artery Insert it with an appropriate depth.

It is appropriate to insert the insertion tube portion 100 into the arterial duct A of the femoral artery and insert it to a position directly under the diaphragm.

Thereafter, saline is connected to the pouch 400 filled with the preserving liquid L and the saline connection cap 310 at the end of the injection unit 110 of the insertion tube 100 exposed in the femoral artery of the body, , Saline solution is first injected through the catheter 300 so that the first balloon 210 and the second balloon 250 are inflated.

The saline solution is injected into the first and second balloons 210 and 250 along the catheter 300, so that it is expanded in the artery line A.

Accordingly, the practitioner hands the first and second balloons 210 and 250, which are inflated, from the outside of the body, and the first balloons 210 are positioned under the diaphragm and the second balloons 250 are positioned in the room immediately above the iliac artery Is confirmed by palpation, the inside of the arterial line, that is, the arterial line (A) is blocked.

At this time, the range in which the first and second balloons 210 and 250 block the aorta is cut off from the diaphragm immediately below the diaphragm to the position below the left and right aneurysm.

As described above, in the state where the arterial line A from the lower portion of the diaphragm to the lower right of the left and right anterior descending artery is blocked by the inflated first and second balloons 210 and 250, the infusion of the insertion tube 100 inserted into the body inguinal region Thereby opening the supply pipe 410 of the pouch 400 connected to the part 110. [

When the supply pipe 410 of the pouch 400 is opened, the storage liquid L filled in the pouch 400 is moved to the inflow hole 107 through the infusion unit 110, The stored preservative liquid L is discharged to the discharge hole 112 of the induction unit 130 and the discharged preservative liquid L is rapidly injected through the arterial line A into the organ side to be extracted.

This is because the inflated first and second balloons 210 and 250 block the portion of the aorta A from the lower right portion of the diaphragm to the lower portion of the left and right anterior descending arteries and therefore the storage liquid L can not move to another portion, It is rapidly injected because it is intensively injected into the organs of the target to be positioned between the position from the position and the position under the left and right superior arteries.

In this way, the storage liquid (L) is rapidly injected into the organ of the target to be extracted, and a hole is made in the inferior vein to drain blood in the blood vessel. At the same time, filling the prepared ice into the abdominal cavity achieves all the purposes of releasing blood in the organ, preserving liquid perfusion, and maintaining a cold state.

While the present invention has been described in connection with what is presently considered to be practical exemplary embodiments, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, It is to be understood that the invention may be embodied in many other specific forms without departing from the spirit or essential characteristics thereof. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

100: insertion tube portion 104: tube 107: inlet hole
110: injection part 112: discharge hole 130: guide part
136: Connecting port 140: Fixing groove 146: Through hole
200: breaking portion 210: first balloon 213, 253: tightening fixing portion
215, 258: Connecting port 220: Coupling pipe 250: Second balloon
300: Catheter 310: Inlet port 400: Pouch
410: supply tube L: preservative A: aorta

Claims (5)

An induction part 130 having an inlet hole 107 through which the liquid is moved and inserted into the femoral artery at the position of the body inguinal region and entering the lower portion of the diaphragm of the aorta A, An insertion tube part 100 composed of an injection part 110 exposed and connected to a preservation liquid L;
A blocking unit 200 mounted on a front end and an intermediate position outer surface of the inflow unit 130 and having a first balloon 210 and a second balloon 250 to be inflated inside the aorta A;
A catheter 300 for supplying saline solution to the first balloon 210 and the second balloon 250 through the inflow hole 107 in the injection unit 110 to which the preserving liquid L is connected; Organs for organ harvesting.
The method according to claim 1,
The induction unit (130)
A discharging hole 112 formed by perforating the storage liquid L injected into the inlet hole 107 to be discharged to the outside of the guide portion 130,
A fixing groove 140 formed at the front end and an intermediate position of the outer surface of the insertion tube 100 so that the first balloon 210 and the second balloon 250 are installed,
Wherein a through hole (146) through which the catheter (300) connected to each balloon (210, 250) is perforated is formed in the fixing groove (140).
3. The method of claim 2,
The first balloon (210) and the second balloon (250) of the blocking portion (200)
Tightening fixing portions 213 and 253 that are tightened and fixed to the fixing grooves 140 of the tube 104 by being expanded and contracted by the inner diameters of the first and second balloons 210 and 250,
And a coupling tube (220) protruding from the tightening fixing parts (213, 253) and connected to the catheter (300) through the through hole (146) of the fixing groove (140).
3. The method of claim 2,
The discharge hole (112)
The first balloon 210 and the second balloon 250 are installed between the fixation groove 140 and the outer surface of the guide portion 130 located in the celiac artery and the superior mesenteric artery and the renal artery origin of the aorta A, Wherein the peritoneal organs are perforated.
5. The method of claim 4,
The first balloon 210 into which the saline solution is injected is expanded at a position immediately below the diaphragm of the ductal tube A,
The second balloon 250 is inflated at a position immediately above the iliac artery of the artery line A to block an unnecessary leaking portion of the preservation liquid L so that the preservation liquid L is injected into the organ to be extracted through the discharge hole Wherein the orifice is inserted into the peritoneal cavity.

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