KR20160075906A - COMPOSITION COMPRISING ALCOHOL EXTRACTS FROM Tranmetes hirsuta FOR TREATING OR PREVENTING HYPERLIPIDEMIA - Google Patents

Abstract

More particularly, the present invention relates to an alcohol extract which is effective for the treatment and prevention of hyperlipidemia and contains an alcohol extract which can be used for the treatment and prevention of obesity as an active ingredient.
The composition comprising the alcohol extract of Trident mushroom as an active ingredient of the present invention inhibits the activity of pancreatic cholesterol esterase and pancreatic lipase, and can be usefully used for the treatment or prevention of hyperlipemia.

Description

TECHNICAL FIELD [0001] The present invention relates to a composition for treating or preventing hyperlipidemia, which comprises an extract of Tranmethorhusta,

More particularly, the present invention relates to a composition for treating or preventing hyperlipidemia, which comprises an alcohol extract of Tridenthuista which is effective for the treatment and prevention of hyperlipidemia.

Hyperlipidemia refers to a disease of high blood fat content. Generally, when total cholesterol is over 240 ㎎ / dl or triglycerides are over 200 ㎎ / dl, it is called hyperlipidemia. Hyperlipidemia is known to be a major cause of hypertension, myocardial infarction, and stroke due to cholesterol blocks the blood vessels and inhibits blood circulation.

BACKGROUND ART In order to prevent or treat hyperlipidemia due to cholesterol, studies have been made on substances that inhibit the absorption of cholesterol. Currently, statin drugs are widely used for the treatment of hyperlipidemia due to inhibition of cholesterol absorption. The drug in this series is an inhibitor of Hmg-CoA reductase and has the effect of inhibiting cholesterol synthesis and lowering blood LDL-cholesterol. In addition, ezetimibe, niacin and fibrate preparations are mainly used. However, there is a possibility that side effects such as myalgia, constipation or digestive disorder and hepatic dysfunction are rarely observed when the drug is administered.

In PCT / KR2012 / 10604, it has been disclosed that the alcohol extract of Pseudomonas aeruginosa can inhibit the activity of pancreatic cholesterol ester raise and lower the absorption of cholesterol, thereby being used as a composition for treating and preventing hyperlipidemia.

In PCT / KR2012 / 10612, it has been disclosed that the water extract of red mulberry can inhibit the activity of pancreatic cholesterol ester raise and lower the absorption of cholesterol, thereby being used as a composition for treating and preventing hyperlipemia.

In PCT / KR2012 / 10550, it has been disclosed that the alcohol extract of the flower shield mushroom can inhibit the activity of pancreatic cholesterol ester raise and lower the absorption of cholesterol, thereby being used as a composition for treating and preventing hyperlipidemia.

On the other hand, in order to treat and prevent hyperlipidemia due to triglyceride, studies have been made on drugs having a mechanism of action that acts on digestive enzymes and inhibits the absorption of fat.

Xenical ^TM (orlistat) is well known as a typical drug. It inhibits the activity of TGL by covalent bonding with serine, which is the active site of triglyceride lipase (TGL), and prevents the fat from being degraded and absorbed .

"Development of specific egg yolk antibodies to the pancreatic lipase domain for obesity inhibition" Kor . J. Microbiol . Biotechnol . Vol. 36, No. 4, 299-306 (2008) proposes a method of inhibiting the absorption of fat by inhibiting the activity of pancreatic lipase using a specific egg yolk antibody.

In PCT / KR2012 / 10558, it has been disclosed that the alcohol extract of yellow vanda mushroom can be used as a composition for treating and preventing obesity by inhibiting the activity of pancreatic lipase.

In PCT / KR2012 / 10602, it has been disclosed that water extract of Chrysanthemum morbus Mushroom can be used as a composition for treating and preventing obesity by inhibiting the activity of pancreatic lipase.

On the other hand, in PCT / KR2012 / 10621, water extract of acacia mushroom suppresses the activity of pancreatic lipase and the activity of raising pancreatic cholesterol ester, and it is known that it can inhibit fat absorption.

However, there is a continuing need for a new mushroom extract which can inhibit the absorption of fat and cholesterol and effectively prevent hyperlipidemia and obesity.

A problem to be solved by the present invention is to provide a novel mushroom extract which can inhibit the absorption of fat and cholesterol without showing any side effects in vivo.

Another object of the present invention is to provide a novel mushroom extract which can inhibit the activity of raising pancreatic cholesterol ester and the activity of pancreatic lipase.

A problem to be solved by the present invention is to provide a composition capable of inhibiting the absorption of fat and cholesterol and treating or preventing hyperlipidemia.

In order to accomplish the above object, the present invention provides a composition for treating or preventing hyperlipidemia, which comprises an alcohol extract having a carbon number of 1 to 10 of Tridenthuista as an active ingredient.

The present invention provides a medicament for treating or preventing hyperlipidemia, which comprises an alcohol extract having a carbon number of 1 to 10 of Tridenthuista as an active ingredient.

The present invention provides a method for treating or preventing hyperlipidemia, comprising administering to an animal an alcohol extract having a carbon number of 1 to 10 of Trident herbicide.

The present invention provides a health functional food for improving or preventing hyperlipidemia, which comprises an alcohol extract having a carbon number of 1 to 10 of Tridenthuista as an active ingredient.

The present invention also provides a composition for inhibiting the activity of raising pancreatic cholesterol ester comprising an alcohol extract having 1 to 10 carbon atoms of Tridenthuista as an active ingredient.

The present invention provides a medicament for inhibiting the activity of raising pancreatic cholesterol ester comprising an alcohol extract having 1 to 10 carbon atoms of Tridenthuista as an active ingredient.

The present invention provides a method for inhibiting the activity of pancreatic cholesterol esterase, comprising administering to an animal an alcohol extract of 1 to 10 carbon atoms of Tridenthuissta.

The present invention provides a health functional food for inhibiting the activity of raising pancreatic cholesterol ester comprising an alcohol extract having a carbon number of 1 to 10 of Tridenthuista as an active ingredient.

The present invention also provides a composition for inhibiting the activity of pancreatic lipase comprising an alcohol extract having 1 to 10 carbon atoms of Tridenthuisuta as an active ingredient.

The present invention provides a medicament for inhibiting the activity of pancreatic lipase comprising an alcohol extract having 1 to 10 carbon atoms of Tridenthuista as an active ingredient.

The present invention provides a method of inhibiting the activity of pancreatic lipase comprising administering to an animal an alcohol extract of 1 to 10 carbon atoms of Tridenthuissta.

The present invention provides a health functional food for inhibiting the activity of pancreatic lipase comprising an alcohol extract having 1 to 10 carbon atoms of Tridenthuista as an active ingredient.

In addition, the present invention can be used as a composition for prevention and treatment of obesity by inhibiting the activity of pancreatic lipase and inhibiting the absorption of fat by the alcohol extract having 1 to 10 carbon atoms in Tridenthuista.

In the present invention, the extract of the above-mentioned Trangerhuista extract, in particular the alcohol extract of Trangerhuisuta, lowers the activity of the pancreatic cholesterol ester raise and effectively inhibits the activity of the pancreatic lipase (triglyceride lipase, TGL) To replace drugs that treat or prevent hyperlipidemia.

In the present invention, the alcohol extract having a carbon number of 1 to 10 of the Trangerhuister may be one obtained by extracting a lower alcohol having 1 to 5 carbon atoms as an extraction solvent. When trmanhyltasota is extracted with a low-alcohol having 1 to 5 carbon atoms, it exhibits excellent digestion and absorption inhibitory effects of the body fat.

Particularly, as such an alcohol extracting solvent, a lower alcohol having 1 to 5 carbon atoms, more preferably ethanol, and most preferably 90 to 100% (v / v) ethanol can be used.

In the present invention, the weight or weight of the mushroom is understood to refer to the weight or weight of the dried mushroom unless otherwise noted.

On the other hand, the alcohol extract of the above-mentioned Transthoracicola may be prepared by a conventional method for producing a plant extract. Preferably, after removing the residue after drying and pulverizing the above-mentioned Trangerhuister, 0.1 to 20 g of the pulverized product is added per 100 ml of the alcohol having 1 to 10 carbon atoms, more preferably, 1 to 20 g of the pulverized product per 100 ml of the extraction solvent, 5 g may be added to the solution. When the content of the truncated trehalose powder is too small as compared with the extraction solvent, the effect of the trangerhirt stearate is not sufficient, and when the amount of the extractant is too large relative to the amount of the extraction solvent, It is not preferable from the viewpoint of productivity because the production cost is increased.

In this case, the extraction conditions are not particularly limited, but it is preferable to mix the trimer hydrides with an alcohol having 1 to 10 carbon atoms as an extraction solvent, and then heat at a temperature of 20 to 60 ° C for 12 to 36 hours, more preferably 30 To 40 < 0 > C for 20 to 24 hours.

Extraction at an excessively low temperature condition requires a long time for extracting an active ingredient, and extraction at an excessively high temperature may deteriorate the activity, which is undesirable.

When the extraction time is too short, the concentration of the effective component to be extracted is low, and when the extraction is performed for an excessively long time, the concentration of the extraction effective ingredient increases with the increase of the extraction time.

Then, the alcohol extract of the Trident herbicide extracted by the above-mentioned method is filtered through a filter or the like, and the filtrate is centrifuged to remove the precipitate, followed by concentration under reduced pressure or concentration, followed by lyophilization.

On the other hand, the content of the alcohol extract of Tranmethorhusta as an active ingredient in the composition for treating or preventing obesity and hyperlipidemia in the above-described embodiment is not limited, but may be preferably 0.001 to 50% by weight. When the content of the alcohol extract of the active ingredient tranquilhyrsuta is less than 0.001% by weight, digestion and absorption of the fat in the body are insignificant. When the content is more than 50% by weight, the effect of increasing the inhibitory activity is insignificant It is not economical. More preferably, the content of the alcohol extract of Tridenthuista in the composition may be 0.01 to 50% by weight, and most preferably 0.1 to 30% by weight.

The present invention provides a medicament for treating or preventing hyperlipidemia or obesity comprising an alcohol extract of Tridenthuista contained in the composition as an active ingredient according to an embodiment. Such medicines containing an alcohol extract of Tridenthuista as an active ingredient may further contain appropriate carriers, excipients and diluents conventionally used for the production thereof.

Examples of carriers, excipients, and diluents that can be included in pharmaceuticals containing the alcohol extract of Tridenthirtta of the present invention as an active ingredient include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, , Alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil have.

Each of the medicines containing the alcohol extract of the present invention as an active ingredient can be used as oral formulations such as powders, granules, tablets, suspensions, emulsions and syrups according to a conventional method.

The oral formulations are meant to include solid and liquid formulations for oral administration and solid formulations for oral administration may include tablets, pills, powders, granules, capsules and the like, For example, starch, calcium carbonate, sucrose or lactose, gelatin and the like in combination with at least one excipient. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid preparations for oral use include suspensions, solutions, emulsions, and syrups. In addition to water and liquid paraffin, which are commonly used simple diluents, various excipients such as wetting agents, sweetening agents, have.

A preferable dosage of the composition containing the alcohol extract of Trident's Hydrusha of the present invention varies depending on the condition and body weight, the degree of disease, the drug form, the administration route and the period, but can be appropriately selected by those skilled in the art. Preferably, the medicinal product containing the alcohol extract of the present invention as an active ingredient is 0.0001 to 100 mg / kg per day on the basis of the amount of the alcohol extract of Tridenthuissta, and more preferably 0.01 to 10 mg / Mg / kg < / RTI > The administration may be carried out once a day or divided into several doses. The dose and the number of administrations do not limit the scope of the present invention in any aspect.

According to another embodiment of the present invention, there is provided a health functional food for improving or preventing hyperlipidemia or obesity comprising an alcohol extract of Tridenthuista as an active ingredient. Herein, the term "health functional food" means a natural product or a processed product containing one or more nutrients, preferably a state of being able to be directly eaten through a certain processing step.

Examples of the health functional food to which the alcohol extract of the present invention can be added include various foods, beverages, gums, tea, vitamin complex, and the like. In addition, in the present invention, the food may contain special nutritional foods (eg, crude oil, infant formula, etc.), meat products, fish products, tofu, mackerel, noodles (eg, (Such as soy sauce, soybean paste, hot pepper paste, mixed sauce), sauces, confectionery (eg snacks), dairy products (eg fermented milk, cheese), other processed foods, kimchi, pickled foods (For example, fruits and vegetables, beverages, fermented beverages, etc.), natural seasonings (eg, ramen soup, etc.). The food, beverage or food additive may be prepared by a conventional production method.

In the present specification, the functional food refers to a food group which is imparted with added value to function and express the function of the food by using physical, biochemical, biotechnological techniques, etc., Means a food which is processed and designed so that the body control function related to restoration and the like is sufficiently expressed to the living body. The functional food may include a food-acceptable food-aid additive, and may further comprise suitable carriers, excipients and diluents conventionally used in the production of functional foods.

In the present specification, beverage means a generic term for drinking or enjoying a taste and is intended to include a functional beverage. The beverage is not particularly limited as long as it contains an alcoholic extract of the above-mentioned Trangerhitsuta as an active ingredient as an essential ingredient at the indicated ratio, and may be added with various flavors or natural carbohydrates as an additional ingredient ≪ / RTI > Examples of such natural carbohydrates include monosaccharides such as disaccharides such as glucose and fructose such as maltose, sucrose and the like and polysaccharides such as dextrins, cyclodextrins and the like, and Xylitol, sorbitol, and erythritol. Natural flavors (tau martin, stevia extract (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharin, aspartame, etc.) can be advantageously used as flavors other than those described above The ratio of the natural carbohydrate may be generally about 1 to 20 g, preferably 5 to 12 g per 100 ml of the composition of the present invention. In addition, the composition of the present invention may be used for natural fruit juice, fruit juice drink, And may further contain flesh for manufacture.

In addition to the above, the health functional food of the present invention may contain various kinds of nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, colorants and heavies (cheese, chocolate etc.), pectic acid and its salts, And salts thereof, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated drinks, and the like. These components can be used independently or in combination. The proportion of such additives is not so critical, but may be selected in the range of 0 to 20 parts by weight per 100 parts by weight of the alcohol extract of the present invention.

In the present specification, functional beverages are used to control the bio-defense rhythm of the beverage group or beverage composition to which the added value is imparted so that the function of the beverage functions for a specific purpose by using physical, biochemical, biotechnological techniques, Means a beverage which has been designed so that the body control function related to restoration and the like is sufficiently expressed in the living body.

The above-mentioned functional beverage is not particularly limited to the other components other than the alcohol extract of the present invention as an essential ingredient in the indicated ratios, and may contain various flavors or natural carbohydrates as an additional ingredient can do. Examples of such natural carbohydrates include monosaccharides such as disaccharides such as glucose and fructose such as maltose, sucrose and the like and polysaccharides such as dextrins, cyclodextrins and the like, and xylitol , Sorbitol, and erythritol. Natural flavors (tau martin, stevia extract (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharin, aspartame, etc.) can be advantageously used as flavors other than those described above The ratio of the natural carbohydrate is generally about 1 to 20 g, preferably 5 to 12 g per 100 ml of the composition of the present invention.

In addition, in a health functional food for the purpose of improving or preventing hyperlipidemia or obesity, the amount of the extract may be 0.01 to 15% by weight of the total food, and the beverage composition may contain 0.02 to 5 g , Preferably 0.3 to 1 g.

According to another embodiment of the present invention, there is provided a method for preparing an alcohol extract of Transthoracis suta as described above.

According to an embodiment of the present invention, there is provided a method for preparing an alcohol extract of Trangerhuistera comprising the steps of: preparing a trangerhuistera; mixing the trangerhuistera with an alcohol having 1 to 10 carbon atoms; At a temperature of 20 to 60 DEG C for 12 to 36 hours.

Meanwhile, in the method for producing an alcohol extract having a carbon number of 1 to 10 according to the above-described embodiment of the present invention, the alcohol is an alcohol having 1 to 5 carbon atoms, more preferably ethanol, most preferably 90 to 100 % (v / v) ethanol. When extracted with such an extraction solvent, it was found that cholesterol from the digestive tract and the effect of reducing the amount of fat absorption from the digestive tract were remarkably exhibited in addition to the effect of inhibiting digestion and absorption of cholesterol and inhibiting digestion and absorption of fat in the extracted extract. The specific extraction time, the extraction temperature, and the mixing ratio of the extractant and the extraction solvent are the same as those described above.

The composition comprising the alcohol extract of Tridenthichter of the present invention as an active ingredient inhibits the activity of pancreatic cholesterol esterase and pancreatic lipase to inhibit digestion and absorption of cholesterol, fat, or both to treat or prevent hyperlipidemia Can be usefully used for the prophylactic use and the therapeutic or prophylactic use of obesity.

FIG. 1 is a graph showing the inhibitory activity of pancreatic cholesterol ester raise of the alcohol extract of Tridenthuista compared with a control.
Fig. 2 is a graph showing the inhibitory activity of pancreatic lipase in the alcohol extract of Tridenthuista compared with the control. Fig.
FIG. 3 is a graph showing measurement of neutral fat absorption inhibition by ethanol extract of Tranmets hirsute.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the structure and effects of the present invention will be described in detail with reference to specific embodiments of the present invention. It should be understood, however, that the following examples are provided for a better understanding of the invention and are not to be construed as limiting the scope of the invention.

Hereinafter, the present invention will be described in detail with reference to examples.

EXAMPLES: Preparation of Tranmetes hirsuta Alcohol Extract

2 g of dried Tranmetes hirsuta powder supplied by Gyeongsangbuk-do Forestry Environment Research Institute was mixed with 50 ml of ethanol as an extraction solvent, and the mixture was extracted by shaking incubation at 37 ° C for 24 hours. The supernatant of the shaking incubator was centrifuged at 2500 rpm for 10 minutes, then the Tranmetes hirsuta alcohol extract was collected and stored at -20 ° C

Experimental Example :

One. Tranmetes hirsuta Pancreatic cholesterol by alcohol extract Esther Reyes  Active measurements and results

Pancreatic cholesterol esterase plays a role in recognizing acyl chain-bearing substrates as non-specific and isolating acyl chains. To measure the pancreatic cholesterol ester raising activity by the Tranmetes hirsuta alcohol extract of the examples, a poison flinic acid cholesterol ester raise made in Sigma chemical was used as an enzyme. The pancreatic cholesterol esterase cleaved the chromogenic substrate (p-nirophenylbutyrate), and the activity of the enzyme was confirmed by the color reaction. The inhibitory effect of the enzyme was measured by the change of absorbance at 405 nm using a microplate reader and calculated as% based on the absorbance at 405 nm of the untreated group of Tranmetes hirsuta alcohol extract.

The activity of the enzyme was determined by the Tranmetes hirsuta alcohol extract of the examples. As a result, it was confirmed that the Tranmetes hirsuta alcohol extract decreased the pancreatic cholesterol ester raising activity. The results are briefly shown in Fig.

2. Measurement and Results of Pancreatic Lipase Activity by Tranmetes hirsuta Alcohol Extract

Pancreatic lipase plays a role in recognizing acyl chain-bearing substrates nonspecifically and isolating acyl chains. To measure pancreatic lipase activity by Tranmetes hirsuta alcohol extract, porcine pancreatic lipase type 2 (Sigma chemical, Type II, manufactured by Sigma Chemical Co., Ltd.) was used. The pancreatic lipase degrades the chromogenic substrate (p-nirophenylbutyrate) and the activity of the enzyme is detected by the color reaction. The inhibitory effect of the enzyme was measured by changing the absorbance at 405 nm using a microplate reader and calculated as% based on the absorbance at 405 nm of the untreated group. The activity of the enzyme by Tranmetes hirsuta alcohol extract And the results showed that the extract of Tranmets hirsuta alcohol of the Example decreased pancreatic lipase activity. The results are briefly shown in Fig.

3. Measurement of Neutral Fat Absorption by Tranmetes hirsute Ethanol Extract

In order to examine whether the ethanol extract of Tranmets hirsute ethanol of the example showing the inhibition effect of pancreatic lipase activity was effective at the individual level, plasma triglyceride was measured. A 0.5 ml oral fat suspension was orally administered to 8-week-old Balb / c mice (male, body weight ~ 25 g) fasted for 16 hours. The fat suspension consisted of 30% olive oil, 0.5% (w / v) carboxymethylcellulose sodium (CMC-Na) and 1% (v / v) Tween 80. In the experimental group, Tranmetes hirsute ethanol extract 200 mg (8 g / kg). After 2 hours, mouse blood was collected and centrifuged at 3000 rpm for 15 minutes at 4 ° C. The amount of triacylglycerol in the serum was measured using a serum triglyceride determination kit (Sigma). As a result, it was confirmed that the extract of Tranmets hirsute alcohol of the example lowered the neutral fat absorption. The results are briefly shown in Fig.

Preparation Example: Preparation using Tranquil Hirsch Alcohol Extract

Production Example 1. Preparation of powder

20 mg of Transthoracic alcohol extract powder, 100 mg of lactose, 10 mg of talc.

The above ingredients were mixed and filled in an airtight container to prepare powders.

Production Example 2. Preparation of tablets

10 mg of Trichirhuisuta alcohol extract, 100 mg of corn starch, 100 mg of lactose, 2 mg of magnesium stearate.

After mixing the above components, tablets were prepared by tableting according to the usual preparation method of tablets.

Production Example 3. Preparation of capsules

10 mg of Transthoracilis alcohol extract powder, 3 mg of crystalline cellulose, 14.8 mg of lactose, and 0.2 mg of magnesium stearate.

The above components were mixed according to a conventional capsule preparation method and filled in gelatin capsules to prepare capsules.

Production Example 4. Production of liquid agent

20 mg of Transthoracic alcohol extract powder, 10 g of isomerized sugar, 5 g of mannitol, and purified water.

Each component was added to purified water in accordance with the usual liquid preparation method and dissolved, and the lemon flavor was added in an appropriate amount. Then, the above components were mixed, and purified water was added thereto. The whole was adjusted to 100 ml with purified water, And sterilized to prepare a liquid preparation.

Production Example 5. Production of Health Food

Vitamin B acetate 0.2 mg, Vitamin C 10 mg, Vitamin B 0.1 mg, Vitamin B 0.15 mg, Vitamin B6 0.5 mg, Vitamin B12 0.2 mg, Vitamin A acetate 70 mg, Vitamin E acetate 1.0 mg, Vitamin B1 0.13 mg, 10 ㎍ of biotin, 1.7 ㎎ of nicotinic acid amide, 50 ㎍ of folate, 0.5 mg of calcium pantothenate, 1.75 mg of ferrous sulfate, 0.82 mg of zinc oxide, 25.3 mg of magnesium carbonate, 15 mg of potassium phosphate, 55 mg of potassium citrate, 90 mg of potassium citrate, 100 mg of calcium carbonate, and 24.8 mg of magnesium chloride.

Although the composition ratio of the above-mentioned vitamin and mineral mixture is comparatively mixed with a composition suitable for health food as a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional method for producing healthy foods , Granules can be prepared and used in the manufacture of health food compositions according to conventional methods.

Claims (20)

A composition for the treatment or prevention of hyperlipidemia comprising an alcohol extract having 1 to 10 carbon atoms of Trangerhuista as an active ingredient. The composition of claim 1, wherein the alcohol is an alcohol having from 1 to 5 carbon atoms. The composition of claim 1, wherein the alcohol is ethanol. 4. The composition of claim 3, wherein the ethanol is 90 to 100% (v / v). The composition according to any one of claims 1 to 4, wherein the extract is extracted with 90 to 100% (v / v) ethanol at a temperature of 20 to 60 DEG C for 12 to 36 hours. . 5. The composition according to any one of claims 1 to 4, wherein the extract is obtained by mixing 0.1 to 20 g of tridentate hydrate per 100 ml of alcohol having 1 to 10 carbon atoms. The composition according to any one of claims 1 to 4, wherein the composition comprises 0.001 to 50% by weight of an alcohol extract having 1 to 10 carbon atoms in the trandium hydr. The composition according to any one of claims 1 to 4, wherein the extract inhibits the activity of pancreatic cholesterol ester raise. The composition according to any one of claims 1 to 4, wherein the extract inhibits the activity of pancreatic lipase. A medicament for the treatment or prevention of hyperlipidemia comprising an alcohol extract having a carbon number of 1 to 10 of Trangerhuista as an active ingredient. 11. The medicament according to claim 10, wherein the medicament is a powder, a granule, a tablet, a suspension, an emulsion, or a syrup. A health-functional food for improving or preventing hyperlipidemia, comprising an alcohol extract having 1 to 10 carbon atoms of Trangerhuista as an active ingredient. 13. The health functional food according to claim 12, wherein the health functional food is food, food additive or beverage. A method for the treatment or prevention of hyperlipidemia comprising administering to a mammal in need thereof a therapeutically effective amount of an alcohol extract having a carbon number of 1 to 10 of Trmanhylsuta. Wherein the activity of the cholesterol esterase is inhibited. Wherein the activity of the pancreatic lipase is inhibited. A method for preparing a composition for the treatment or prevention of hyperlipidemia by drying an extracted liquid obtained by mixing dried trmanhylsuta with an alcohol having from 1 to 10 carbon atoms. 18. The method according to claim 17, wherein the extract is obtained by extracting dried Trident herbicide and alcohol having 1-10 carbon atoms in a shaking incubator. 19. The method according to claim 18, characterized in that the supernatant of the shake incubator is centrifuged to obtain an extract. A composition for the treatment or prevention of obesity comprising an alcohol extract having a carbon number of 1 to 10 of Trangerhuista as an active ingredient.

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