KR20160062532A - Spray apparatus comprising air and coating solution injection nozzle - Google Patents
Spray apparatus comprising air and coating solution injection nozzle Download PDFInfo
- Publication number
- KR20160062532A KR20160062532A KR1020140165405A KR20140165405A KR20160062532A KR 20160062532 A KR20160062532 A KR 20160062532A KR 1020140165405 A KR1020140165405 A KR 1020140165405A KR 20140165405 A KR20140165405 A KR 20140165405A KR 20160062532 A KR20160062532 A KR 20160062532A
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- KR
- South Korea
- Prior art keywords
- coating liquid
- stent
- nozzle
- cleaning liquid
- coating
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B17/00—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups
- B05B17/04—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods
- B05B17/06—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations
- B05B17/0607—Apparatus for spraying or atomising liquids or other fluent materials, not covered by the preceding groups operating with special methods using ultrasonic or other kinds of vibrations generated by electrical means, e.g. piezoelectric transducers
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The injection device for an ultrasonic stent coating for spraying a coating liquid onto a stent fixed by a stent transfer device according to the present invention and generating ultrasonic waves to coat the surface of the stent is supplied with a coating liquid containing a drug from a coating liquid supply part And a cleaning liquid spraying part for spraying and discharging the cleaning liquid from an air discharge part and a cleaning liquid supply part for generating ultrasonic waves in spraying the coating liquid and discharging the air supplied from the air supply part, A coating liquid spray nozzle for spraying the coating liquid toward the upper side of the stent while being spaced apart from the stent by a predetermined distance and a coating liquid spray nozzle for spraying the coating liquid from the coating liquid spray nozzle to the coating liquid spray nozzle, Wherein the air discharge portion includes a supply member An ultrasonic nozzle tip member for generating ultrasonic waves toward the stent at the time of spraying the coating liquid and a through hole formed at the center of the ultrasonic nozzle tip member and for supplying compressed air supplied through an air supply member connected to the air supply unit to the stent And the air discharge nozzle discharges compressed air discharged through the air discharge nozzle to focus the coating liquid injected from the coating liquid injection nozzle with the stent.
Description
BACKGROUND OF THE
Generally, a stent is developed for the treatment of coronary artery. When a blood or body fluid does not flow smoothly in a blood vessel, a gastrointestinal tract, or a bile duct due to a malignant or benign disease, Is a cylindrical medical material used to normalize the flow of blood or body fluids by inserting it into a closed or clogged area.
More specifically, coronary artery stenosis, such as arteriosclerosis, is generally treated using percutaneous transluminal coronary angioplasty, which was performed in 1977 by Gruentzig < RTI ID = 0.0 > ) Has been inserted into a balloon-shaped device called a catheter, and has been actively practiced worldwide since its first operation.
However, conventional catheter-based coronary angioplasty has been associated with acute closure and restenosis during or after the procedure.
Therefore, in order to reduce the problems of restenosis and the like, there have been conventionally used atherectomy, rotabulation, transluminal extraction catheter, excimer laser coronary angioplasty and stent, New methods such as the insertion of a magnetic field have been studied.
However, in these methods, there is no way to reliably relieve the restenosis phenomenon other than the procedure of widening and maintaining the physically restenosed region by inserting the stent.
Even if the stent is used to maintain the extension after percutaneous coronary angioplasty (PTCA), there is a problem that restenosis occurs at a rate of about 20 to 30%, although the restenosis rate is low, as compared with the case of only PTCA.
In addition, for example, in the treatment of a patient suffering from an esophageal cancer, when expanding the narrowed esophageal region by a physical force in accordance with the proliferation of the cancer and allowing the patient to ingest the food, May be performed.
However, conventional metal stents have a problem in that as the size of the tumor increases with the lapse of time, the invasion of the cancer continues between the gaps of the stent metal mesh, resulting in a restenosis phenomenon in which the esophageal lumen narrows again.
In addition, since the intestinal thickening is the main cause of restenosis after insertion of the stent, recently, a drug capable of inhibiting the migration and proliferation of vascular smooth muscle cells, which is a direct cause of intimal thickening, is coated on the stent, A drug release type stent for preventing restenosis by releasing a drug has been developed.
Examples of the above agents include taxol (Paclitaxel), mitomycin C, adriamycin, genistein, tyrphostin, cytochalasin, ), Sirolimus (Rapamycin), and the like. Coating of such a drug is performed by coating a part or all of the stent so that a coating solution in which the drug and the biocompatible polymer are dissolved in the solvent is present on the surface of the stent .
The conventional stent coating method includes, for example, an immersion method in which a stent is immersed in a coating solution, followed by drying, and a spray method in which a coating solution is sprayed.
Here, in the dipping method, there is a case where a web (coating between struts) or a bridge is generated in the space portion of the stent by immersion, and in addition to the possibility that the web or bridge affects the mechanical function of the stent, If a part of the web or bridge is destroyed or peeled and flows to peripheral blood vessels after mounting, it may cause blood circulation disorder, which is not preferable.
On the other hand, the spray method can form a coating layer by spraying a coating liquid onto the outer and / or inner circumferential surface of the stent while rotating the stent and / or moving the spray nozzle, for example, as shown in Japanese Patent No. 10-1374073.
However, as in the prior art, the spray method is more liable to waste the coating liquid than the amount of the sprayed coating liquid adhered to the stent, and in particular, when the scattered coating liquid is adsorbed to the coating apparatus, There arises a problem that the operation is difficult or the management cost is increased.
SUMMARY OF THE INVENTION The present invention has been conceived in order to solve the above-mentioned problems, and it is an object of the present invention to provide a stent with a coating solution uniformly sprayed to a stent, The present invention also provides an injection apparatus for an ultrasound stent coating having an air injection nozzle and a coating liquid injection nozzle which can be used for a stent coating.
However, the object of the present invention is not limited to the above-mentioned objects, and other objects not mentioned can be clearly understood by those skilled in the art from the following description.
In order to achieve the above object, an ultrasonic stent-coating spraying apparatus for spraying a coating liquid onto a stent fixed in position by a stent transfer device according to an embodiment of the present invention and generating ultrasonic waves to coat the surface of the stent, And a cleaning liquid supply unit for supplying the cleaning liquid from the air discharge unit and the cleaning liquid supply unit for generating the ultrasonic waves when spraying the coating liquid and discharging the compressed air supplied from the air supply unit, Wherein the coating liquid injecting unit includes a coating liquid spray nozzle for spraying the coating liquid toward the upper side of the stent while being spaced apart from the stent by a predetermined distance and a coating liquid spray unit for connecting the coating liquid spray nozzle and the coating liquid supply unit, Wherein the coating liquid is supplied to the coating liquid injection nozzle Wherein the air discharging portion includes an ultrasonic nozzle tip member for generating an ultrasonic wave toward the stent when spraying the coating liquid and a through hole formed at the center of the ultrasonic nozzle tip member, And an air discharge nozzle for discharging the compressed air supplied through the member toward the stent. The compressed air discharged through the air discharge nozzle focuses the coating liquid injected from the coating liquid spray nozzle with the stent do.
According to another aspect of the present invention, there is provided an injection apparatus for coating an ultrasonic stent, wherein the coating liquid injection nozzle is disposed at a predetermined angle with respect to the ground.
According to another aspect of the present invention, there is provided an injection apparatus for coating an ultrasonic stent, the apparatus including a cleaning liquid injection unit for spraying a cleaning liquid supplied from a cleaning liquid supply unit, the cleaning liquid injection unit being disposed at a position facing the coating liquid injection nozzle, A cleaning liquid spray nozzle for spraying the cleaning liquid toward the coating liquid spray nozzle and the ultrasonic nozzle tip member, and a cleaning liquid supply part for supplying the cleaning liquid to the cleaning liquid spray nozzle, And the cleaning liquid supply member supplying the cleaning liquid to the cleaning liquid supply unit.
According to another aspect of the present invention, there is provided an injection apparatus for coating an ultrasonic stent, wherein the coating liquid spray nozzle is disposed closer to the ultrasonic nozzle tip member than the cleaning liquid spray nozzle.
In addition, the ultrasonic stent-coating spraying apparatus according to the present invention may include a coating liquid spray nozzle, an ultrasonic nozzle tip member, and a vertical transfer unit for vertically moving the cleaning liquid spray nozzle. The vertical transfer unit may include a coating liquid spray nozzle, A support member to which the nozzle tip member and the cleaning liquid jetting nozzle are mounted; a pair of the support member, which is disposed between the upper frame and the lower frame in a direction perpendicular to the paper surface and on which the support member is mounted, A rotary member which is formed in a cylindrical shape and has a thread on an outer circumferential surface of a lower end of the lower end thereof and which is disposed between the guide bars and rotatably supports the support member in a vertical direction, And a knob member for rotating the rotary member All.
According to the injection apparatus for coating an ultrasonic stent with the air injection nozzle and the coating liquid injection nozzle according to the present invention, the coating liquid containing the medicament is precisely sprayed toward the stent in a predetermined direction by using air injected at high pressure during the ultrasonic coating There is an advantage that the coating liquid can be uniformly coated on the stent.
1 is a perspective view schematically showing a stent coating system to which an injection apparatus for coating an ultrasonic stent according to the present invention is applied.
2 is a front view showing an injection apparatus for an ultrasonic stent coating having an air injection nozzle and a coating liquid injection nozzle according to an embodiment of the present invention.
3 is a partially enlarged view showing a jetting portion including an air jetting nozzle and a coating liquid jetting nozzle according to the present invention.
FIG. 4 is an exemplary view illustrating a process of coating a stent through an injection device for coating an ultrasonic stent according to the present invention.
FIG. 5 is an exemplary view illustrating a process of cleaning a nozzle through an injection device for coating an ultrasonic stent according to the present invention.
FIG. 6 is a perspective view schematically showing a stent delivery apparatus constituting the stent coating system of the present invention. FIG.
7 is a cross-sectional view showing the configuration of the stent delivery device of Fig.
Fig. 8 is an exemplary view showing a joint state of a joint portion and an LM driver in the stent delivery device of Fig. 6; Fig.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a detailed description of preferred embodiments of the present invention will be given with reference to the accompanying drawings. In the following description of the present invention, detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.
Embodiments in accordance with the concepts of the present invention can make various changes and have various forms, so that specific embodiments are illustrated in the drawings and described in detail in this specification or application. It is to be understood, however, that it is not intended to limit the embodiments according to the concepts of the present invention to the particular forms of disclosure, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.
It is to be understood that when an element is referred to as being "connected" or "connected" to another element, it may be directly connected or connected to the other element, . On the other hand, when an element is referred to as being "directly connected" or "directly connected" to another element, it should be understood that there are no other elements in between. Other expressions that describe the relationship between components, such as "between" and "between" or "neighboring to" and "directly adjacent to" should be interpreted as well.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In this specification, the terms "comprises ",or" having ", or the like, specify that there is a stated feature, number, step, operation, , Steps, operations, components, parts, or combinations thereof, as a matter of principle.
FIG. 1 is a perspective view schematically showing a stent coating system to which an injection apparatus for coating an ultrasonic stent according to the present invention is applied. FIG. 2 is a perspective view of a stent coating system for applying an ultrasonic stent coating apparatus according to an embodiment of the present invention. FIG. 3 is a partially enlarged view showing a jetting portion including an air jetting nozzle and a coating liquid jetting nozzle according to the present invention. FIG.
Referring to the drawings, a
The
The coating
The coating
The coating
The medicament contained in the coating liquid 3 used in the
An
The ultrasonic
An
The
The cleaning
The cleaning
Therefore, the cleaning
The
The coating
A pair of guide bars 144 and 144 may be disposed in the first through
In addition, the
A
Although not specifically shown, a thread may be formed on the inner circumferential surface of the second through
The
FIG. 4 is an exemplary view illustrating a process of coating a stent through an injection device for coating an ultrasonic stent according to the present invention. FIG. 5 is a view illustrating a process of cleaning a nozzle through an injection device for coating an ultrasonic stent, Fig.
Referring to the drawings, the
That is, when the
Therefore, the sprayed
The
5, the ultrasonic stent-
Therefore, there is a feature that the clogging phenomenon of the nozzle due to the
FIG. 6 is a perspective view schematically showing a stent delivery system constituting the stent coating system of the present invention, FIG. 7 is a cross-sectional view showing the structure of a stent delivery system, FIG. 8 is a view showing a state where the joint part and the LM drive part Fig.
Referring to the drawings, the
Particularly, the
The
In addition, the
One end of the
The rotational
The
Therefore, the rotational power generated through the rotational
The
Accordingly, the linear motion of the
The
More specifically, the
Therefore, it is possible to prevent the scattered coating liquid from being adsorbed to other constituent parts of the
In the present invention, the shape of the case is shown as a rectangle. However, if the coating liquid can be prevented from being adsorbed by the transfer device, the shape of the case can be variously changed.
The
The
As shown in the drawing, the
A
The
Particularly, it is possible to guide the movement of the
While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. will be. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.
1: stent 10: stent coating system
100: Injection device for ultrasonic stent coating
110:
111: coating liquid spray nozzle 112: coating liquid supply member
113:
120:
121: air supply part 122: ultrasonic nozzle tip member
123: through hole 124: air discharging member
125: Air supply member
130: Cleaning liquid dispenser
131: Cleaning liquid spray nozzle 132: Cleaning liquid supply member
133: Cleaning liquid supply unit
140: Vertical transfer part
141: support member 142: first through hole
143: second through hole 144: guide bar
145: rotating member 146: threaded
147: Handle member
150: upper frame 160: lower frame
200: Stent delivery device
Claims (5)
A coating liquid dispensing part for dispensing a coating liquid containing a medicament from a coating liquid supply part and injecting the coating liquid;
An air discharge unit for generating ultrasonic waves when spraying the coating liquid and discharging compressed air supplied from the air supply unit; And
And a cleaning liquid spraying unit for spraying the cleaning liquid supplied from the cleaning liquid supply unit,
The coating liquid injector may include:
A coating liquid spray nozzle for spraying the coating liquid toward the upper side of the stent while being spaced apart from the stent by a predetermined distance; And
And a coating liquid supply member connected between the coating liquid spray nozzle and the coating liquid supply unit and supplying the coating liquid to the coating liquid spray nozzle,
The air discharge portion
An ultrasonic nozzle tip member for generating ultrasonic waves toward the stent when injecting the coating liquid; And
And an air discharge nozzle disposed in a through hole formed at the center of the ultrasonic nozzle tip member and discharging compressed air supplied through an air supply member connected to the air supply unit toward the stent,
Wherein the compressed air discharged through the air discharge nozzle focuses the coating liquid injected from the coating liquid injection nozzle with the stent.
Wherein the coating liquid spraying nozzle is disposed in a state of being inclined at a predetermined angle with respect to the ground surface.
Further comprising a cleaning liquid jetting section for jetting cleaning liquid supplied from the cleaning liquid supply section,
Wherein the cleaning liquid jetting unit comprises:
A cleaning liquid spray nozzle disposed at a position facing the coating liquid spray nozzle and spraying the cleaning liquid toward the coating liquid spray nozzle and the ultrasonic nozzle tip member; And
And a cleaning liquid supply member connected between the cleaning liquid supply unit for supplying the cleaning liquid and the cleaning liquid spray nozzle and supplying the cleaning liquid to the cleaning liquid spray nozzle. Spraying device.
Wherein the coating liquid spray nozzle is disposed closer to the ultrasonic nozzle tip member than the cleaning liquid spray nozzle.
And a vertical transfer unit for vertically moving the coating liquid spray nozzle, the ultrasonic nozzle tip member, and the cleaning liquid spray nozzle,
Wherein the vertical transfer unit comprises:
A support member to which the coating liquid spray nozzle, the ultrasonic nozzle tip member, and the cleaning liquid spray nozzle are mounted;
A pair of guide bars disposed between the upper frame and the lower frame in a direction perpendicular to the paper and mounted with the support members and guiding movement of the support members in the vertical direction;
A rotary member formed in a cylindrical shape and having a thread formed on an outer peripheral surface of a lower end from an upper end thereof and disposed between the guide bars to vertically transfer the support member by rotation; And
And a grip member mounted on an upper end of the rotating member to rotate the rotating member.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020140165405A KR20160062532A (en) | 2014-11-25 | 2014-11-25 | Spray apparatus comprising air and coating solution injection nozzle |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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KR1020140165405A KR20160062532A (en) | 2014-11-25 | 2014-11-25 | Spray apparatus comprising air and coating solution injection nozzle |
Publications (1)
Publication Number | Publication Date |
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KR20160062532A true KR20160062532A (en) | 2016-06-02 |
Family
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Family Applications (1)
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KR1020140165405A KR20160062532A (en) | 2014-11-25 | 2014-11-25 | Spray apparatus comprising air and coating solution injection nozzle |
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KR (1) | KR20160062532A (en) |
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2014
- 2014-11-25 KR KR1020140165405A patent/KR20160062532A/en not_active Application Discontinuation
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