KR20160041670A - Blood analysis apparatus attachable to smartphone - Google Patents

Blood analysis apparatus attachable to smartphone Download PDF

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KR20160041670A
KR20160041670A KR1020140136084A KR20140136084A KR20160041670A KR 20160041670 A KR20160041670 A KR 20160041670A KR 1020140136084 A KR1020140136084 A KR 1020140136084A KR 20140136084 A KR20140136084 A KR 20140136084A KR 20160041670 A KR20160041670 A KR 20160041670A
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smartphone
blood
biosensor
pin
case
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KR101645811B1 (en
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이승노
김현기
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(주) 더바이오
이승노
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Priority to PCT/KR2014/009886 priority patent/WO2016056694A1/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1468Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose

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Abstract

The present invention relates to a smartphone attachable device for analyzing blood, which can be easily detachable to a local wireless communication reader such as a smartphone. According to the present invention, the smartphone attachable device for analyzing blood comprises: a case (100) for forming the outside of the smartphone attachable device for analyzing blood; a clip (200) attached on one surface of the case (100) for pressurizing other objects; a roof antenna (300) installed inside the case (100); a driving circuit (400) connected to the roof antenna (300) for enabling the smartphone attachable device for analyzing blood to play a role of an NFC tag by generating and supplying power, and enabling the smartphone attachable device to perform signal processing and fixed operation; and a port (500) inserted with an electrochemical biosensor for transmitting an electrochemical signal generated in the electrochemical biosensor to the driving circuit (400).

Description

TECHNICAL FIELD [0001] The present invention relates to a blood analyzer,

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a blood analyzer using an NFC sensor tag, and more particularly, to a smartphone-attached blood analyzer capable of easily attaching and detaching to and from a short range wireless communication reader such as a smart phone.

Near Field Communication (hereinafter, referred to as NFC) is a communication technique in which wireless data is transmitted and received within a relatively short distance of about 10 cm. NFC is similar to Bluetooth but it does not have to be set up between devices like Bluetooth, it has short communication distance, excellent encryption technology, and it is attracting attention as a next generation short range communication technology because of its excellent security and low price. Since the latest smartphones have NFC functions built in, they can take advantage of the NFC functions and the range of NFC usage is wide.

In the conventional NFC sensor tag, since the power consumption of the sensor is high, the data of the sensor tag is stored by using a separate power supply device (battery). Therefore, the battery of the sensor tag is very difficult to be practically used in terms of the size and cost of the sensor tag.

Depending on the smartphone maker, NFC tag stickers are provided by default when purchasing smartphones. If you have these tag stickers, you can set up NFC functions as you want. NFC-enabled smartphones have built-in NFC apps to enable this feature. In addition, the devices that provide the NFC function also provide the functions of Bluetooth, such as photo, video, and app, and the NFC has better security because it can be done at a shorter distance than Bluetooth. Also, there are many uses depending on whether to leave a secret message between each other or to use smart phone function setting and storage using tag sticker. The commands stored in the NFC tag sticker can be deleted with a simple delete button and can be reused indefinitely several times. In addition to the stickers provided by the manufacturer of the smartphone, this tag sticker can be purchased separately. The price of the tag sticker is also low, so it is quite fun and convenient to use one by one in office, bed, Can be used.

The recently released Android operating system based smartphones have the above-mentioned NFC function basically, but some smart devices such as the iPhone 5 do not have this NFC function. However, NFC function cases are sold separately, so users can buy them if necessary.

An electronic device using such an NFC function is disclosed in Patent Document 1. The device disclosed in Patent Document 1 is a 'near-field wireless communication based electrochemical biosensor' invented by the present inventor. As shown in FIG. 1, a smart phone 1 as an NFC reader and a biosensor 3 as an NFC tag And measures the blood glucose level in the blood using the smartphone (1).

However, since the electrochemical biosensor based on the conventional short range wireless communication is difficult to align the NFC module integrated in the smartphone with the NFC integrated biosensor, general users without expert knowledge are inconvenient to use. In addition, since the locations of the short-range wireless communication components are different in each smartphone maker, the biosensor that has worked well in certain smartphones often fails to operate in other smartphones.

Application No. 10-2013-0086035 (March 23, 2013)

[0001] The present invention relates to a smartphone-attached hematology analyzer that applies an NFC function embedded in a smartphone in accordance with an increase in the penetration rate of a smartphone (smart device) (Mounted) By rotating the smartphone flip case by 180 ° and then touching the app for blood glucose measurement or by rotating the smartphone flip case by 180 °, the smartphone maker is automatically connected to the built-in NFC device, The blood-analyzing apparatus comprising:

When the user inserts the disposable electrochemical biosensor into the port (biosensor insertion portion) of the smartphone attachment type blood analysis device, a message to inject blood is displayed on the blood glucose measurement app, which is a display part of the smartphone, Is injected into the biosensor, the smart blood cell analyzer automatically measures the blood and reports the result of the diagnosis through the data communication to the display part of the smartphone, And an object of the present invention is to provide a smartphone attachment type blood analysis apparatus as far as possible.

According to an aspect of the present invention, there is provided a smartphone-attached blood analyzer capable of short-range wireless communication with a smartphone, the smartphone-attached blood analyzer comprising: ; A clip attached to one surface of the case to press another object; A loop antenna installed inside the case; A driving circuit connected to the loop antenna for generating and supplying a power source for performing a signal processing and a predetermined operation so that the smart-phone-attached blood analyzer can serve as an NFC tag, and an electrochemical biosensor inserted therein, And a port for transmitting an electrochemical signal generated from the chemical biosensor to the driving circuit.

In addition, the cradle-type smartphone-attached blood analyzer according to the present invention is a smartphone-attached blood analyzer according to the present invention; And a bottom plate hinged to the main body for accommodation, wherein the smartphone-attached blood analyzer is inserted into the main body.

The smartphone-attached blood analyzer (including the cradle type) according to the present invention can be easily installed and utilized in a reader such as a smart phone having an embedded NFC function, so that it is convenient to use. In particular, if you are using a smartphone, download the smartphone app for blood analysis (blood glucose, anemia, blood coagulation time measurement, etc.), launch the app, insert an electrochemical biosensor for diagnostic purpose, It is possible to easily perform field diagnosis such as blood glucose measurement.

In addition, when used as a blood glucose meter in conjunction with a smart phone, it is easy to carry, and unlike conventional blood glucose meters, there is no need to replace the battery because it is unnecessary to replace the battery. There is an advantage to manage.

1 is a schematic diagram of a conventional short-range wireless communication based electrochemical biosensor
2 is a perspective view of a smartphone-attached blood analyzer according to the present invention;
FIG. 3 is an internal configuration diagram of a smartphone-attached blood analyzer according to the present invention
FIG. 4 is a view showing the state of use of the smartphone attachment blood analyzer according to the present invention in a cover of a smartphone
5 shows a case where a biosensor for blood glucose measurement is inserted into a port
6 is an exemplary diagram of a communication protocol between a smartphone-attached blood analyzer and a smartphone according to the present invention.
Fig. 7 is a schematic view showing a blood-
8 is a flowchart illustrating a process of configuring a smartphone-attached blood analyzer according to the present invention as a cradle type
Fig. 9 is a view showing the state of use of the stand-type smartphone-attached blood analyzer
FIG. 10 is a view showing another embodiment of a smartphone attachment type blood analyzer according to the present invention
Fig. 11 is a diagram showing the state of use of the smartphone-attached blood analyzer shown in Fig. 10

BRIEF DESCRIPTION OF THE DRAWINGS The above and other features and advantages of the present invention will be more apparent from the following detailed description taken in conjunction with the accompanying drawings, in which: FIG.

FIG. 2 is a perspective view of a smartphone attachment type blood analysis apparatus according to the present invention, and FIG. 3 is an internal configuration diagram of a smartphone attachment type blood analysis apparatus according to the present invention.

The smartphone attachment blood analyzer 10 according to the present invention includes a case 100, a clip 200 attached to the case, a loop antenna 300 installed inside the case 100, and a loop antenna 300 connected to the loop antenna 300 And a port 500 exposed to the outer surface of the case 100 and electrically connected to the driving circuit 400.

The case 100 surrounds the loop antenna 300, the driving circuit 400, and the port 500 and is a constituent element of the smartphone attachment blood analysis apparatus according to the present invention. Generally, it is made of plastic material which is light and has appropriate strength and can transmit electromagnetic waves, but it can be formed of other materials. However, it should be transparent in the NFC frequency band because it needs to be capable of short-range wireless communication with the NFC reader. For example, it is necessary to be able to pass electromagnetic waves in the 13.56 MHz band, which is currently the most commonly used NFC frequency band. The case 100 is preferably formed in the form of a flat plate for reasons such as the arrangement of the loop antenna 300 and the driving circuit 400, and ease of detachment and attachment with the NFC reader.

A coupling slit 110 may be formed on a side surface of the case 100. This is necessary for implementing the smartphone-attachable blood analyzer 10 according to the present invention in the form of a cradle, which will be described later.

The clip 200 is attached to one side of the case 100 so that the case 100 and the clip 200 press both sides of different objects so that the smartphone attachment type blood analysis apparatus 10 according to the present invention is attached And the like. Here, the other object may be a cover of a smart phone or the like or a smart phone body.

FIG. 4 shows a state in which a smartphone-attached blood analyzer according to the present invention is attached to a cover of a smartphone. 4 (a), when the smartphone-attached blood analyzer 10 according to the present invention is attached to a cover of a smartphone, the smartphone cover is rotated 180 degrees as shown in FIG. 4 (b) Since the phone-attached blood analyzer 10 can be brought close to the rear surface of the smartphone, i.e., the position where the NFC module is embedded, it is difficult to view the screen of the smartphone when using the NFC function using the smartphone. There is no effect. At this time, if part or all of the opposite surface of the case 100 on which the clip 200 is attached is formed of a high friction coefficient material such as silicone rubber, the smartphone-attached blood analyzer according to the present invention may be mounted on a cover And when the smartphone cover is rotated by 180 ° and then placed on the floor, the smartphone does not flow even if there is a certain degree of inclination on the floor (in this case, as opposed to that shown in FIG. 4 (a) Should be attached so that it protrudes outward.

The loop antenna 300 is a component that enables communication with an NFC reader such as a smart phone. In the case where the loop surface of the loop antenna is disposed in parallel to the plate surface of the case 100, the smartphone-attached blood analyzer 10 according to the present invention is disposed parallel to the back surface of the smartphone, The loop surface is placed in the propagation direction of the radio wave, so that the signal induced in the loop antenna is maximized and the energy efficiency is improved. Further, the loop antenna 300 may be provided with a matching circuit so that the MCI / EMC function may be performed.

The driving circuit 400 is connected to the loop antenna 300 to generate and supply power from a reader such as a smart phone so that the smartphone-attached blood analyzer 10 according to the present invention can act as an NFC tag, And to perform certain operations. The driving circuit 400 includes an NFC bridge chip 410 for processing a short-range wireless communication signal and a communication protocol and generating power, a power chip 420 for converting the power generated by the NFC bridge chip 410 and supplying the power to other devices, An MCU 430 for performing an arithmetic operation and an analog-to-digital conversion, and an operation chip 440 for performing an operation.

The NFC bridge chip 410 is connected to the loop antenna 300 and processes signals and protocols. The NFC bridge chip 410 is a component that receives current induced in the loop antenna 300 and supplies power to the entire driving circuit 400. As a representative NFC bridge chip 410, there is TNB-131M of 3A logic company, and TNB-131M has an energy harvesting function through induction current, so that NFC tag can be implemented without battery.

The power supply chip 420 is a component that regulates or regulates the power transmitted from the NFC bridge chip 410. Since the power transmitted from the NFC bridge chip 410 may fluctuate with time, it may be a component that stabilizes the power.

The MCU 430 is a component that performs arithmetic and analog-to-digital conversion. Although the operation chip 440 may differ depending on the characteristics of the operation chip 440, the operation chip 440 generates analog data. Therefore, it is necessary to convert the analog data into digital data, and the MCU 430 plays the role. In addition, it is necessary to process the values measured by the operation chip 440 and to transfer the data to the NFC reader through the NFC function. The MCU 430 also performs this function. That is, the MCU 430 performs the same function as the CPU of the computer.

The operation chip 440 is a component that senses an electrochemical signal transmitted from the port 500, amplifies the signal if necessary, and transmits the amplified signal to the MCU 430. The operation chip 440 may have various forms depending on the role of the smartphone attachment type blood analysis apparatus 10 according to the present invention. For example, one or more circuits having various electrochemical sensing functions, such as a blood glucose measuring circuit, an anemia measuring circuit, and a blood coagulation time measuring circuit. The following is an example of a blood glucose measurement circuit, but a similar approach is possible for circuits that perform other functions.

The port 500 is an element for inserting an electrochemical biosensor such as a biosensor for blood glucose measurement to transmit an electrochemical signal generated from the biosensor to the operation chip 440. The port 500 is composed of a plurality of metal pins according to the type of the biosensor. For example, a biosensor for blood glucose measurement requires a 4-pin port.

FIG. 5 illustrates a case where a biosensor for blood glucose measurement is inserted into a port, and FIG. 6 illustrates an example of a communication protocol between a smartphone-attached blood analyzer and a smartphone according to the present invention. The first port P1 is connected to the reference electrode E1 of the biosensor for blood glucose measurement and the second pin P2 is connected to the strip recognition electrode E2 , The third pin (P3) is connected to the blood inlet recognition electrode (E3), and the fourth pin (P4) is connected to the working electrode (E4).

When you run the app for blood glucose measurement on your smartphone, you will see a message such as "Please insert the strip" and insert the biosensor for blood glucose measurement into the 1st pin (P1) and 2nd pin (P2 (The reference electrode and the strip recognition electrode are electrically connected to each other in the portion indicated by the dotted line in FIG. 5). In the smartphone-attached blood analyzer 10 according to the present invention, The insertion of the biosensor is recognized and the blood glucose measurement process is prepared. Next, when a user inputs blood into the blood inflow section, a guide message such as " Blood is buried " is output from the smartphone, and since the reference electrode and the blood inflow recognition electrode are short-circuited, (P3) is short-circuited to recognize the blood flow and drives the blood glucose measurement process. At this time, if the first pin (P1) and the third pin (P3) are short-circuited from the beginning, it can be recognized that the biosensor for blood glucose measurement has already been used.

Next, the blood glucose level in the blood can be measured by measuring the electrochemical signal between the first pin P1 and the fourth pin P4 for a predetermined measurement time (for example, 5 seconds). The blood glucose level can be determined according to a predetermined formula using an electrochemically generated current signal at the time of measurement, and temperature correction can be performed through a temperature sensor built in the blood type analyzer. If the blood glucose level is transmitted to the smartphone through the NFC communication in the smartphone-attached blood analyzer 10 according to the present invention, the blood glucose level can be immediately confirmed on the screen of the smartphone.

Although the biosensor for measuring blood glucose has been described above, the same process can be applied to other types of measurement sensors.

FIG. 7 illustrates a smartphone-attached blood analysis apparatus of a cradle type, FIG. 8 illustrates a process of configuring a smartphone-attached blood analysis apparatus according to the present invention as a cradle type, FIG. FIG. 2 is a view showing the state of use of a smartphone-attached blood analyzer of a stand type according to the present invention. The bed type smartphone-attached blood analyzer includes a main body 600 for a smart-phone-attached blood analysis apparatus according to the present invention and a bottom plate 700 hinged to the main body 600 .

The mounting body 600 is configured to include a mounting jaw 610 and a hinge rod 620, and a coupling protrusion 630 may be further formed.

The mounting jaw 610 is formed by protruding from the mounting body 600 so as to mount an NFC reader such as a smart phone when the mounting body 600 is installed at an angle.

The hinge rod 620 is formed at the lower end of the mounting body so as to be inserted into the hinge hole 710 of the bottom plate 700 to allow rotation and angle adjustment between the mounting body 600 and the bottom plate 700.

The coupling protrusions 630 are formed on the inner side of two arms arranged at equal intervals of the width of the smartphone attachment type blood analysis apparatus 10 according to the present invention, (Not shown). Therefore, by adjusting the degree (height) of the slide fastening of the smartphone attachment blood analysis device 10 according to the present invention and the engagement protrusion 630 after the NFC reader is mounted on the mounting jaw 610, The smart-phone-attached blood analysis apparatus 10 according to the present invention can maintain optimum communication.

The combining slit 110 may be formed in the mounting body 600 and the engaging projection 630 may be formed in the smartphone attachment blood analysis apparatus 10 according to the present invention. It is more convenient and more apparent that the coupling slit 110 is formed in a depressed shape rather than the coupling protrusion 630 protruding from the blood analyzer 10. In the present embodiment, the combining slit 110 and the coupling protrusion 630 have been described as an example. However, if the smart-phone-attaching blood analyzer 10 according to the present invention can be stably installed in the main body 600, Other types of coupling means may be used.

The bottom plate 700 is formed with a hinge hole 710 at one side so as to be hinged to the mounting body 600. 7, when the mounting body 600 and the bottom plate 700 are overlapped with each other and the space occupied by the mounting body 600 is reduced and the NFC reader is required to be mounted, the bottom plate 700 Can be rotated with respect to the mounting body 600 so that the mounting body 600 stands at an angle and the NFC reader can be placed on the mounting jaw 610. It is also possible to have a structure in which a hinge bar is formed on the bottom plate 700 on the mounting main body 600.

Fig. 10 shows another embodiment of a smartphone-attached blood analyzer according to the present invention, and Fig. 11 shows a state of use thereof.

The smartphone attachment type blood analysis apparatus 10 according to the present invention may be a U-shaped type in which an inner space 120 is formed in the case 100 by extending one end of the case 100 instead of having a clip. At this time, it is preferable that the open portion of the U-shape is formed to be narrower than the U-shaped folded portion so as to hold the smartphone cover well, and the friction portion 130 is formed so as to hold the smartphone cover better It is possible.

10 A smartphone-attached blood analyzer according to the present invention
100 Case 110 Coupling slit
120 internal space 130 friction part
200 Clip 300 Loop Antenna
400 driver circuit 410 NFC bridge chip
420 power chip 430 MCU
440 operation chip 500 port
600 mounting body 610 mounting chin
620 hinge pin 630 engaging projection
700 Base plate 710 Hinge hole

Claims (14)

As a smartphone-attached blood analyzer capable of short-range wireless communication with a smartphone,
A case 100 forming an outer wall of the smartphone-attached blood analyzer;
A clip (200) attached to one surface of the case (100) to press another object;
A loop antenna 300 installed inside the case 100;
A driving circuit 400 connected to the loop antenna 300 for generating and supplying a power source to perform a signal processing and a predetermined operation so that the smartphone attachment blood analysis device can serve as an NFC tag,
And a port (500) through which an electrochemical biosensor is inserted to transmit an electrochemical signal generated from the electrochemical biosensor to the driving circuit (400).
The method according to claim 1,
Wherein the case (100) is in the form of a plate, and the loop surface of the loop antenna (300) is arranged in parallel with the plate surface of the case (100).
The method according to claim 1,
And a part or all of the opposite surface of the case (100) on which the clip (200) is attached is made of a silicone rubber material.
The method according to claim 1,
The driving circuit 400 is connected to the loop antenna 300 to process a signal and a protocol and receives an electric current induced in the loop antenna 300 to supply electric power to the driving circuit 400. [ (410);
A power supply chip 420 for regulating or regulating power transmitted from the NFC bridge chip 410;
An MCU 430 for performing arithmetic and analog-to-digital conversion,
And an operation chip (440) for sensing an electrochemical signal transmitted from the port (500) and transmitting the electrochemical signal to the MCU (430).
The method of claim 4,
Wherein the operation chip (440) comprises at least one of a blood glucose measuring circuit, an anemia measuring circuit, and a blood coagulation time measuring circuit.
The method according to claim 1,
The port 500 includes a first pin P1 connected to the reference electrode E1 of the biosensor and a second pin P2 connected to the strip recognition electrode E2, P1) and the second pin (P2), thereby recognizing the insertion of the biosensor.
The method of claim 6,
Wherein the biosensor is a biosensor for measuring blood glucose, the driving circuit 400 includes a blood glucose measurement circuit, and the port 500 is connected to the blood inlet recognition electrode E3 of the biosensor The method according to claim 1, further comprising a pin (P3), and recognizing whether the inflow of blood or the reuse of the biosensor is detected by sensing a short circuit between the first pin (P1) and the third pin (P3) Blood analysis device.
The method of claim 7,
The port 500 further comprises a fourth pin P4 connected to the working electrode E4 of the biosensor for measuring blood glucose and the fourth pin P4 connected between the first pin P1 and the fourth pin P4. And measuring the blood glucose level in the blood by measuring the electrochemical signal.
The method according to claim 1,
Wherein the loop antenna (300) further comprises a matching circuit to perform an MCI / EMC function.
The method according to claim 1,
The smartphone attachment blood analysis apparatus 10 is a U-shaped type in which the clip 100 is provided instead of the clip 100 and one end of the case 100 is bent so that the inner space 120 is formed in the case 100 A smartphone attachment type blood analysis device characterized by.
A smartphone-attached blood analyzer (10) according to any one of claims 1 to 10;
A mounting body 600 into which the smartphone-attached blood analyzer 10 is inserted,
And a bottom plate (700) hinged to the mounting body (600).
The method of claim 11,
And a mounting tongue (610) protruding from the mounting body (600).
The method of claim 11,
A hinge pin 620 is formed on one of the mounting body 600 or the bottom plate 700 and a hinge hole 710 is formed on the other of the mounting body 600 and the bottom plate 700. The mounting body 600 and the bottom plate 700 ) Are hinged to each other. ≪ IMAGE >
The method of claim 11,
The binding slit 110 is formed in one of the smart blood cell attachment type blood analyzer 10 or the main body 600 and the other is formed with a coupling protrusion 630, Wherein the device (10) and the mounting body (600) are slidably coupled.
KR1020140136084A 2014-10-08 2014-10-08 Blood analysis apparatus attachable to smartphone KR101645811B1 (en)

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PCT/KR2014/009886 WO2016056694A1 (en) 2014-10-08 2014-10-21 Smartphone attachment type blood analysis device

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