KR20160012157A - Cell collection device - Google Patents

Abstract

[PROBLEMS] When a cell harvesting member collects cells of the cervix, it does not fall out of the tubular body, but provides a means of easily separating from the tubular body after collection.
A cell harvesting apparatus 10 includes a cell harvesting member 12 capable of being attached to the front end of a tubular body 11 and a tubular body 11, And an operating member 13 for changing the posture of the lock portion 31 in the lock posture or the release posture. The operation member 13 is actuated on the proximal end side in a state of being inserted into the tube 11, thereby changing the posture of the lock portion 31.

Description

CELL COLLECTION DEVICE

 The present invention relates to a cell harvesting apparatus capable of removing a cell harvesting member at the tip of a tubular member or a bar member.

In the diagnosis of cervical cancer, cells are collected from the cervix and the collected cells are stained on a slide glass and observed with a microscope. This diagnosis is called cervical cytology. In addition, the collected cells are returned to an examination center or the like and observed at an examination center.

A cell equipped with a brush or the like at the distal end of the bar member is used for collecting cells in the cervix (see Patent Document 1). Cells of the uterine cervix are collected on the brush by rotating the bar member with the brush of the device in contact with the cervix. Then, the brush attached with the cells is rubbed on a slide glass, and the cells are smudged. When the inspection is performed in the inspection center, only the part of the device such as the brush of the device is broken into the container and the container is returned to the inspection center.

Patent Document: Japanese Patent Application Laid-Open No. 4-500320

For example, in Patent Document 1, a thin breaking point 16 is provided in the shaft portion 15 in order to put only a part of the device such as a brush into the container. Therefore, the shaft portion 15 can be broken at the break point 16 so that only the brush end portion can be put into the container. It is also conceivable that a structure capable of removing the brush or the like from the tubular body is adopted.

However, when taking the cells of the cervix, the device is repeatedly moved or rotated in the pulling direction. This operation may break the break point 16 in the vagina or cause the brush or the like to come off the tube.

SUMMARY OF THE INVENTION The present invention has been made in view of the above problems, and an object of the present invention is to provide a means by which a cell harvesting member can be easily separated from a tubular body or a stem after harvesting, without withdrawing from the tubular body when collecting cells of the uterine cervix .

(1) A cell harvesting apparatus according to the present invention comprises a tubular body having a first end and a second end, a cell harvesting member attachable to the first end of the tubular body, and a cell harvesting member attached to the first end of the tubular body A locking position for holding the cell harvesting member in a state of being mounted on the first end of the tubular body, or a locking posture for holding the cell harvesting member in a state of being mounted on the first end of the tubular body And an operating member for changing the attitude of the locking portion in the unlocking posture. And the operating member is moved in the posture by operating the second end side in a state of being inserted into the tubular body.

In collecting cervical cells, the cell harvesting apparatus is used in a state where the cell harvesting member is attached to the tubular body, and the operating member is in the locking posture. In this state, the cell harvesting member is fixed to the tubular body, and the cell harvesting member does not fall out of the tubular body even if the tubular body is moved longitudinally or rotated about the longitudinal direction. Further, since the operation of the operating member is performed at the second end side of the tubular body, even if an external force is applied to the first end side of the tubular body, the unlocking portion does not suddenly become the disengaged posture.

After the cervical cells are collected, the operating member is operated at the second end of the tube so that the locking portion is changed from the locked position to the released position. As a result, the cell harvesting member can be separated from the tubular body.

(2) The locking portion may be provided on the operating member.

As a result, the number of components is reduced, and the structure of the apparatus is simplified.

(3) The cell harvesting member has an elastically deformable deformation portion, and the locking portion may press the deformation portion to the tubular body in the locking posture.

The cell harvesting member is fixed to the tubular body by friction generated between the deformed portion pressed against the lock portion and the tubular body. It is not necessary to provide a structure for engaging a cell harvesting member and a tubular body such as a hook or a hole, thereby simplifying the structure.

(4) The deformed portion may be engaged with the tubular body by being pressed against the lock portion.

The cell harvesting member is firmly fixed to the tubular body by the deformation portion and the tubular body being engaged.

(5) The operating member may be held in a state in which the locking portion is in the locking posture by being screwed to the tubular body at the second end side of the tubular body.

This prevents the lock portion from unintentionally changing its posture from the lock posture to the release posture.

(6) The operating member may be held on the second end side of the tubular body in a state in which the locking portion is brought into the locking posture by being engaged with the tubular body.

This prevents the lock portion of the operating member from suddenly changing from the locked position to the released position unintentionally.

(7) The locking portion includes a fitting portion for fitting the cell harvesting member and the tubular body around a virtual line passing through the first end and the second end so as not to be rotatable with each other, And may have a screw coupling portion.

The rotation of the tubular body is transmitted to the cell collection member by the fitting portion, and the force in the direction in which the cell collection member is separated from the tubular body is transmitted by the threaded portion. Thus, since the force is transmitted from the tubular body to the cell harvesting member by dividing the tubular body into the fitting portion and the screw coupling portion, the load on the locking portion is reduced.

(8) The locking portion includes a fitting portion in which the cell harvesting member and the tubular body are fitted so as to be mutually non-rotatable around imaginary lines passing through the first and second ends, and a holding portion in which the operating member and the cell harvesting member are engaged It may have a loose engagement portion.

The rotation of the tubular body is transmitted to the cell collection member by the fitting portion, and the force in the direction in which the cell collection member is separated from the tubular body is transmitted by the engagement portion. Since the force is transmitted from the tubular body to the cell harvesting member by dividing the engaging portion and the engaging portion, the load on the locking portion is reduced.

(9) The engaging portion is engaged with the cell harvesting member in a locking posture at a first rotational position of the operating member about an imaginary line passing through the first and second ends, And may not be engaged with the cell harvesting member.

As a result, the engagement portion changes its posture with a simple operation.

(10) The present invention relates to a cell harvesting apparatus in which an engaging portion is provided on one side of a rod or a cell harvesting member, and the cell harvesting member is detachable at the distal end of the rod. Wherein the engaging portion includes a convex portion or a concave portion extending along the longitudinal direction of the rod or the cell harvesting member and a protruding portion or a concave portion protruding toward the outside of the rod or the cell harvesting member and elastically protruding from the engaging posture to the releasing posture And a pressing portion that protrudes to the outer surface of the rod or the cell harvesting member and is pressed to change the posture from the engagement posture to the release posture. A cylindrical portion into which the convex portion or the concave portion and the pawl can be inserted into the inner space, a concave portion or a convex portion into which the convex portion or the concave portion can be inserted, And a hole through which the hook in the engagement posture is inserted and engageable is provided.

The cell harvesting device is used for harvesting cervical cells, with cell harvesting members mounted on the bar. The convex portion or the concave portion and the hook of the engaging portion are inserted into the inner space of the cylindrical portion so that the convex portion is inserted into the concave portion and the hook is engaged with the hole of the peripheral wall so that the cell- And is fixed with respect to the rotational direction about the longitudinal direction.

After the cervical cells are harvested, the pressurizing portion is pressed to change the posture of the engagement portion to the release posture. The hooks of the releasing posture fall out of the hole of the peripheral wall of the cylindrical portion. As a result, the cell harvesting member and the bar can move relative to each other in the longitudinal direction and the rotating direction, and the cell harvesting member is pulled out of the bar.

(11) The pawl, the pressurizing portion, and the hole are provided at a position symmetrical with respect to a center line along the longitudinal direction of the rod or the cell harvesting member, and the convex portion and the concave portion are formed on the center line .

A pair of claws, a pressurizing portion and a hole are provided. Therefore, even when some external force is applied to one pressing portion at the time of collecting the cervical cells and the corresponding hook is released from the hole and released from the hole, The cell harvesting member does not fall out of the bar because it is in the engaged state.

Further, since the pair of hooks, the pressurizing portion and the hole are provided at symmetrical positions with respect to the center line along the length direction of the bar or cell harvesting member, there is little possibility that an external force is applied to both pressing portions at once.

(12) The engagement portion may be provided in the bar material.

Thereby, it is not necessary to contact the cell harvesting member when pressing the pressing portion.

(13) The convex portion may be provided on the bar material.

This makes it easy to increase the distance between the convex portion and the hook in the bar material, so that the amount of movement of the hook from the engagement posture to the release posture can be increased. As a result, the amount of engagement between the hook and the hole of the peripheral wall can be increased.

(14) The convex portion may have a tapered shape tapering toward the tip, and the tapered surface may be in pressure contact with the concave portion in a state in which the cell collection member is attached to the distal end of the bar material.

The pushing force of the operator and the rotating force of the operator are transmitted to the cell harvesting member by the pressure contact between the tapered surface of the convex portion and the concave portion so that the load on the engaging portion between the hook and the hole of the circumferential wall It does not.

According to the present invention, by operating the operating member at the second end of the tubular body, the posture of the lock portion that keeps the tubular body and the cell harvesting member in the mounted state is changed. Therefore, when collecting cells of the cervical portion, , And the cell harvesting member is easily separated from the tubular body after harvesting.

Further, according to the present invention, since the convex portion is inserted into the concave portion and the hook in the engaging posture is engaged with the hole in the peripheral wall of the cylindrical portion, when the cells of the cervix are taken, the cell- After harvesting, the cell harvesting members are easily separated from the bar stock.

1 is a perspective view showing an external configuration of a cell sampling device 10 according to a first embodiment.
2 is a perspective view showing the external structure of the tubular body 11. Fig.
[Fig. 3] Fig. 3 is a perspective view showing the external structure of the cell harvesting member 12. [Fig.
[Fig. 4] Fig. 4 is a perspective view showing the external structure of the operating member 13. Fig.
5 is an enlarged cross-sectional view showing a cross section including a centerline 102 of the cell sampling device 10;
6 is an enlarged cross-sectional view of the cell harvesting apparatus 10 in a state in which the elastic pieces 42, 43 are changed to attitude in an unfolding posture.
[Fig. 7] Fig. 7 is a perspective view showing the external configuration of the cell sampling device 50 according to the second embodiment.
8 is a perspective view showing the external configuration of the tube body 51. FIG.
[Fig. 9] Fig. 9 is a perspective view showing the outer structure of the cell-harvesting member 52. Fig.
10 is a perspective view showing an external configuration of the operating member 53. Fig.
11 is a cross-sectional view taken along the line XI-XI in FIG. 7;
12 is an enlarged cross-sectional view showing a cross section including the centerline 102 of the cell collection device 50. FIG.
[Fig. 13] Fig. 13 is an enlarged cross-sectional view of the cell collection device 50 showing a process in which the male threaded portion 61 is changed to the unfolded posture.
[Fig. 14] Fig. 14 is a perspective view showing the vicinity of the engaging portion 72 of the cell sampling device 70 according to the modified example of the second embodiment.
15 is an enlarged cross-sectional view showing a cross section including a centerline 102 of the cell collection device 70;
16 is an enlarged cross-sectional view of the cell sampling device 70 in a state in which the engaging portion 72 is changed to the unlocked posture.
[Fig. 17] Fig. 17 is a perspective view showing the external configuration of the cell collection device 80 according to the third embodiment.
18 is a perspective view showing the outer structure of the tubular body 81 and the cap 84. Fig.
19 is a perspective view showing the outer configuration of the cell-harvesting member 52. FIG.
20 is a perspective view showing the external configuration of the operating member 53. Fig.
21 is an enlarged cross-sectional view showing a cross section including the center line 102 of the cell sampling device 50;
22 is an enlarged cross-sectional view of the cell harvesting apparatus 80 in a state in which the lock portion 96 has been changed to a disengaged posture.
[Fig. 23] Fig. 23 is a sectional view showing a modification of the fourth embodiment.
24 is a cross-sectional view showing a release posture in a modified example of the fourth embodiment.
25 is a perspective view showing the external configuration of the cell collection device 110 according to the fifth embodiment.
Fig. 26 is a perspective view showing the outer structure of the tube 111, the operating member 113, and the coil spring 131. Fig.
FIG. 27 is a perspective view showing the outer configuration of the cell-gathering member 112; FIG.
28 is a perspective view showing the external structure of the lock member 114. FIG.
29 is an enlarged cross-sectional view showing a cross section including a centerline 102 of the cell collection device 110;
30 is an enlarged cross-sectional view of the cell harvesting apparatus 110 in a state in which the lock member 114 has changed posture to the release posture.
[Fig. 31] Fig. 31 is a perspective view showing the external configuration of the cell collection device 150 according to the sixth embodiment.
32 is a perspective view showing the external structure of the tube body 151;
33 is a perspective view showing the external configuration of the cell harvesting apparatus 152. FIG.
Fig. 34 is a perspective view showing the external configuration of the operating member 153; Fig.
35 is a cross-sectional view taken along the line VV in Fig. 31;
36 is an enlarged cross-sectional view of a cell collection device 150 showing a cross section including a center line 102 of the cell collection device 150. FIG.
37 is an enlarged cross-sectional view of the cell harvesting apparatus 150 showing a process in which the male threaded portion 161 is changed to the unfolded posture.
38 is a perspective view showing the external configuration of the cell collection device 210 according to the seventh embodiment.
39 is a perspective view showing the external structure of the rod material 211. Fig.
FIG. 40 is a perspective view showing the outer structure of the cell-harvesting member 212; FIG.
41 is an enlarged cross-sectional view showing a cross section including the center line 102 of the cell collection device 210;
42 is an enlarged cross-sectional view of the cell harvesting apparatus 210 in a state where the claws 222 and 223 are changed to the unfolded posture.
43 is an enlarged cross-sectional view showing a modified example in which the concave portion 246 is provided in the rod member 211 and the convex portion 221 is provided in the cell-gathering member 212. FIG.
44 is an enlarged sectional view showing a modified example in which only one of the pair of claws 222 and 223, the pressing portions 224 and 225 and the holes 249 and 250 are provided.
45 is an enlarged cross-sectional view of a modified example in which a coil spring 235 is provided in the concave portion 246 of the cell harvesting member 212;
46 is an enlarged cross-sectional view showing a release state of a modified example in which a coil spring 235 is provided in the concave portion 246 of the cell harvesting member 212;
47 is an exploded perspective view showing a modified example of the cell harvesting apparatus 210;
48 is an exploded perspective view showing a modified example of the cell harvesting apparatus 210;
49A is a view showing a convex portion 221 of the rod material 211 along a center line 102 in a modified example of the cell harvesting apparatus 210 and FIG. A view of a concave portion 246 of the cell harvesting member 212 in a modified example of the apparatus 210 along a center line 102;
50 is an enlarged cross-sectional view along a vertical direction (direction in which the pressing portions 224 and 225 are installed) showing a state in which the cap 300 is mounted in a modified example of the cell sampling device 210 And 50B are enlarged cross-sectional views along the left and right directions (directions in which the pressing portions 224 and 225 are not provided) showing a state in which the cap 300 is mounted in a modified example of the cell harvesting apparatus 210 .
51A is an enlarged cross-sectional view along a vertical direction (direction in which the pressing portions 224 and 225 are installed) showing a state in which the cap 300 is mounted in a modified example of the cell sampling device 210 And 51B are enlarged cross-sectional views along the left and right directions (directions in which the pressing portions 224 and 225 are not provided) showing a state in which the cap 300 is mounted in the modified example of the cell harvesting apparatus 210 .
52 is an enlarged cross-sectional view along a vertical direction (direction in which the pressing portions 224 and 225 are installed) showing a state in which the cap 300 is mounted in a modified example of the cell sampling device 210 And 52B are enlarged cross-sectional views along the left and right directions (directions in which the pressing portions 224 and 225 are not provided) showing a state in which the cap 300 is mounted in a modified example of the cell harvesting apparatus 210 .
53 is an enlarged sectional view along the vertical direction (direction in which the pressing portions 224 and 225 are installed) showing a state in which the cap 300 is mounted in a modified example of the cell sampling device 210 And 53 (B) are enlarged cross-sectional views along the left and right directions (directions in which the pressing portions 224 and 225 are not provided) showing a state in which the cap 300 is mounted in the modified example of the cell harvesting apparatus 210 .
54A is an enlarged cross-sectional view along a vertical direction (a direction in which the pressing portions 224 and 225 are installed) showing a state in which the cap 300 is mounted in a modified example of the cell sampling device 210 And 54 (B) are enlarged cross-sectional views along the left and right directions (directions in which the pressing portions 224 and 225 are not provided) showing a state in which the cap 300 is mounted in a modified example of the cell harvesting apparatus 210 .

Hereinafter, embodiments of the present invention will be described with reference to the drawings. It goes without saying that the present embodiment is merely an example of the present invention, and that the present embodiment may be appropriately changed without departing from the gist of the present invention.

[First Embodiment]

1, the cell harvesting apparatus 10 has a tubular body 11, a cell harvesting member 12, and an operating member 13. The cell harvesting member 12 is detachably mounted on the distal end side of the tubular body 11. The operating member (12) is inserted into the tube body (11). In this embodiment, the direction in which the elongated tubular body 11 extends is referred to as the longitudinal direction 101. An imaginary line passing through the center of the tube 11 along the longitudinal direction 101 is referred to as a center line 102. The direction of rotation about the center line 102 is referred to as the rotation direction 103. [ The side of the tubular body 11 on which the practitioner grips is referred to as a proximal side (right side in Fig. 1) and the side where the cell collection member 12 is mounted is referred to as a distal side (left side in Fig. 1). The tip end of the tubular body 11 corresponds to the first end, and the base end of the tubular body 11 corresponds to the second end.

[Tubular body (11)]

As shown in Figs. 1 and 2, the tubular member 11 is a member of a long tubular shape elongated in the longitudinal direction 101. The tubular member 11 has openings at its front end and rear end, respectively, and the inner space is continuous between the front end and the rear end. The tubular body 11 is formed, for example, as a molded product of a synthetic resin. The material and shape of the tube 11 are not particularly limited, and may be polygonal, for example. The external dimensions of the tubular body 11 and the length of the longitudinal direction 101 are set so as to be best suited for the operator to reach the proximal end of the cell harvesting member 12 to the cervical portion.

As shown in Fig. 2 and Fig. 5, holes 20 and 21 are provided on the tip end side of the tube 11. The holes 20 and 21 penetrate the wall of the tube 11 in the radial direction from the tip end side of the tube 11, respectively. The holes 20 and 21 have a quadrangular shape formed by their peripheries. The holes 20 and 21 are arranged as a pair at positions symmetrical with respect to the center line 102. A female thread 22 is formed on the inner wall of the base end side of the tubular body 11. The female screw 22 is screwed to the male screw 33 of the operating member 13. [

[Cell harvesting member (12)]

3 and 4, the cell harvesting member 12 has a main body 40, a brush 41, and resilient pieces 42, 43. The main body 40 is, for example, a molded product of synthetic resin. The brush 41 is inserted into a hole 44 formed at the tip end side of the main body 40 and fixed with an adhesive or the like. The brush 41 has a plurality of synthetic resin fibers fixed on a shaft made of stainless steel. The structure or shape of the brush 41 may be any known one such as a molded product of an elastomer. Therefore, as in this embodiment, the shaft extends along the center line 102 of the tube 11, and the fibers may be radially extended from the shaft, or other shapes may be employed.

The main body 40 has a substantially cylindrical outer shape. On the base end side surface of the main body 40, convex portions 48, 49 protruding from the surface are provided. The convex portions 48 and 49 each have a semi-cylindrical shape. The diameter of the circle along the outer circumferential surface of the convex portions 48 and 49 is slightly smaller than the inner diameter of the tube body 11. The protrusions 48 and 49 are inserted into the openings of the front end of the tube 11 and engaged with each other so that the main body 40 is positioned and mounted at a position where the respective axes coincide with the tip of the tube 11.

Elastic pieces 42 and 43 protrude from the base-end side surface of the main body 40. The elastic pieces 42 and 43 are each in the form of a thin plate that can be elastically deformed and are disposed at positions where the front and back surfaces are parallel to each other and are symmetrical with respect to the center line 102. [ The elastic pieces 42 and 43 have hooks 45 and 46 at their respective projecting ends. The claws 45 and 46 protrude outward from the elastic pieces 42 and 43, respectively, away from the center line 102. The hooks 45 and 46 are sized and shaped so as to enter the holes 20 and 21 of the tube 11.

The distance between the front ends of the hooks 45, 46 is shorter than the inner diameter of the tubular body 11. The elastic pieces 42 and 43 do not come into pressure contact with the opening edge of the tube 11 and the inner wall of the tube 11 in the state where the elastic pieces 42 and 43 are not elastically deformed , Entry and exit are possible. In other words, the cell harvesting member 12 attached to the distal end of the tubular body 11 in a state where the elastic pieces 42 and 43 are not elastically deformed is positioned in the longitudinal direction of the tubular body 11 101 are in a state along the gravity direction, they easily fall out of the tubular body 11 by gravity. The elastic pieces 42 and 43 correspond to the deformed portion.

Between the elastic pieces 42 and 43 on the surface on the base end side of the main body 40, a hole 47 extending toward the tip side along the center line 102 is formed. The hole 47 is cylindrical in shape, and the distal end portion of the locking portion 31 of the operation member 13, which will be described later, can enter.

(Operation member 13)

4 and 5, the operating member 13 has a rod portion 30, a lock portion 31, and a handle portion 32. As shown in Fig. The rod portion 30 is a substantially columnar member elongated in the longitudinal direction 101. The length of the rod portion 30 is equal to or slightly shorter than the length of the tubular body 11 in the longitudinal direction 101. The rod portion 30 has an outer diameter that can be inserted into the inner space of the tubular body 11. 4, the rod portion 30 may be formed with a plurality of elongated grooves in the longitudinal direction 101 to reduce the amount of resin.

A locking portion 31 is provided at the tip end side of the operating member 13. The lock portion 31 is integrally formed with the rod portion 30 and is a portion whose tip is tapered at the tip end side of the rod portion 30. The distal end of the locking portion 31 is an outer diameter allowing entry into the hole 47 from between the elastic pieces 42 and 43 of the cell harvesting member 12. [ The proximal end side of the lock portion 31 is continuous with the outer circumferential surface of the rod portion 30 and its outer diameter is larger than the interval between the surfaces of the elastic pieces 42 and 43 facing each other.

At the base end of the rod section (30), a handle section (32) is provided. The grip portion 32 is a cylindrical shape having an outer diameter larger than the outer diameter of the rod portion 30 and the inner diameter of the tube 11. The outer diameter of the rod portion 30 is slightly smaller than the inner diameter of the tube body 11. [ On the outer circumferential surface of the grip portion 32, a plurality of concave grooves along the longitudinal direction are formed at intervals in the circumferential direction to prevent slippage.

On the outer peripheral surface of the base end portion of the rod portion 30, a male screw 33 is formed. The male screw 33 is inserted into the inner space of the tube 11 and screwed to the female screw 22 of the tube 11.

[Use of cell harvesting apparatus (10)] [

The cell harvesting apparatus 10 may be configured such that the cell harvesting member 12 is attached to the tubular body 11 and the operating member 13 is in a state of locking the locking member 31 Lt; / RTI > The cell harvesting member 12 is fixed with respect to the tubular body 11 in the longitudinal direction 101 and the rotating direction 103 when the locking portion 31 is in the locking posture. Therefore, when the operator grips the proximal end side of the tubular body 11 and performs an operation such as pulling, pulling, or rotating, the force is transmitted to the cell harvesting member 12 so that the cell harvesting member 12 moves integrally with the tubular body 11 Or rotate.

The operation member 13 is inserted from the base end and the male thread 33 of the operating member 13 and the tubular body 11 are inserted into the tubular body 11 with the cell collecting member 12 mounted on the tip end of the tubular body 11, The lock portion 31 of the operating member 13 is in a state in which the locking portion 31 reaches the distal end side of the tubular body 11 most. At this time, the distal end of the lock portion 31 enters the hole 47 of the cell harvesting member 12. The circumferential surface of the lock portion 31 enters between the elastic pieces 42 and 43 of the cell harvesting member 12 and the side of the claws 45 and 46 of the elastic pieces 42 and 43 is moved away from the centerline 102 And elastically deforms away from and outward. The operating member 13 does not move in the longitudinal direction 101 with respect to the tube 11 unless the screw connection between the male screw 33 and the female screw 22 is released.

The elastic pieces 42 and 43 are pressed outward by the locking part 31 and elastically deformed so that the claws 45 and 46 enter the holes 20 and 21 of the tubular body 11 respectively. The thin plate portions on the side of the main body 40 are sandwiched between the locking portions 31 and the peripheries of the holes 20 and 21 of the tubular body 11 than the claws 45 and 46 of the elastic pieces 42 and 43 And is pressed by the tubular body 11 by the lock portion 31. The elastic pieces 42 and 43 are sandwiched between the locking portions 31 and the holes 20 and 21 of the tubular body 11 so that the elastic pieces 42 and 43 are inclined relative to the tubular body 11 in the longitudinal direction 101, Or does not rotate along the direction of rotation 103. [ Even if a large force is applied to the cell harvesting member 12, the elastic pieces 42 and 43 are engaged with the tubular body 11 in the longitudinal direction It is prevented from moving along the rotation axis 101 or rotating along the rotation direction 103. The posture (the position in the longitudinal direction 101 in this embodiment) of the lock portion 31 that elastically deforms the elastic pieces 42 and 43 in this manner corresponds to the lock posture.

After the cervical cells are collected, as shown in Fig. 6, the proximal end side of the tubular body 11 and the handle 32 of the operating member 13 are held by the practitioner so that the handle 32 is held in the tubular body 11 . The threaded engagement of the female screw 22 of the tubular body 11 and the male screw 33 of the operating member 13 is released. As the operating member 13 is moved in the direction of extracting from the base end of the tubular body 11, the locking portion 31 is separated from the elastic pieces 42 and 43 of the cell harvesting member 12. When the lock portion 31 is not pressed, the elastic pieces 42 and 43 are resiliently returned to their original state. That is, the distance between the tips of the hooks 45 and 46 is shorter than the inner diameter of the tube 11. The posture (in this embodiment, the position in the longitudinal direction 101) of the lock portion 31 in which the resilient pieces 42 and 43 are not elastically deformed corresponds to the release posture.

The elastic pieces 42 and 43 returned to the original state can enter and exit without any pressing contact with the opening edge of the tube 11 and the inner wall of the tube 11. [ Therefore, the cell harvesting member 12 mounted on the tip of the tubular body 11 is moved in the longitudinal direction 101 of the tubular body 11 along the gravity direction with the cell harvesting member 12 downward, And easily escapes from the tubular body 11. The missing cell harvesting member 12 is accommodated in a storage container (not shown).

[Function and effect of the first embodiment]

According to the first embodiment, in collecting the cervical cells, the cell harvesting member 12 is mounted on the tubular body 11 and the cell collecting member 12 is attached to the tubular body 11 by the locking portion 31 of the operating member 13. [ The cell collecting member 12 does not come off from the tubular body 11 even if the tubular body 11 is moved in the longitudinal direction 101 or rotated in the rotating direction 103. [ Since the operating member 13 is operated at the proximal end side of the tubular member 11, the locking member 31 does not move (change posture) unintentionally even when an external force is applied to the distal end side of the tubular member 11. After the cervical cells are collected, the operation member 13 is operated at the proximal end side of the tubular body 11 so that the locking part 31 moves (changes posture) and the cell harvesting member 12 moves from the tubular body 11 And becomes detachable.

Further, since the lock portion 31 is provided on the operation member 13, the number of parts of the cell sampling device 10 is reduced, and the device structure is simplified.

The cell harvesting member 12 has elastically deformable elastic pieces 42 and 43 and the elastic pieces 42 and 43 are pressed by the tubular body 11 so that the locking pieces 31 The cell harvesting member 12 is fixed to the tubular body 11 by the friction generated between the elastic pieces 42 and 43 pressed against the tubular body 11 and the tubular body 11. Although the hooks 45 and 46 are provided on the elastic pieces 42 and 43 in the present embodiment, the cell collecting member 12 can be attached to the tubular body 11 even if the hooks 45 and 46 are not provided. The structure of the cell harvesting apparatus 10 is simplified by not providing the hooks 45 and 46.

Since the claws 45 and 46 of the elastic pieces 42 and 43 are engaged with the holes 20 and 21 of the tube 11 by being pressed by the locking portion 31, 11).

The operating member 13 is held on the base end side of the tube body 11 so as not to move in the longitudinal direction 101 with respect to the tube body 11 by screwing the female screw 22 and the male screw 33, The operation member 13 unexpectedly moves in the longitudinal direction 101 to prevent the cell harvesting member 12 from escaping from the tube 11.

[Second Embodiment]

7, the cell collection device 50 has a tubular body 51, a cell harvesting member 52, and an operating member 53. As shown in Fig. The cell harvesting member 52 is detachably mounted on the distal end side of the tubular body 51. The operating member (53) is inserted into the tube body (51). In the present embodiment, the direction in which the elongated tubular body 51 extends is referred to as the longitudinal direction 101. An imaginary line passing through the center of the tube 51 along the longitudinal direction 101 is referred to as a center line 102. The direction of rotation about the center line 102 is referred to as the rotation direction 103. [ 7), and the side on which the cell harvesting member 52 is mounted is referred to as a distal end side (left side in Fig. 7). The tip of the tube 51 corresponds to the first end, and the base end of the tube 51 corresponds to the second end.

[Tubular body (51)]

As shown in Figs. 7 and 8, the tubular body 51 is a tubular member whose outer shape is elongated in the longitudinal direction 101 and which is hexagonal. The tubular body 51 has a front end and a rear end respectively opened, and a circular inner space is continuous between the front end and the rear end. The tubular body 51 is formed, for example, as a molded product of a synthetic resin. The material and shape of the tubular body 11 are not particularly limited, and may be, for example, a cylindrical shape. The outer dimensions of the tubular body 51 and the length of the longitudinal direction 101 are set so as to be best suited for the operator to reach the base end side and to allow the cell harvesting member 52 to reach the cervical portion.

 As shown in Figs. 11 and 12, grooves 54 are provided on the surface of the tube 51 on the tip side. The groove 54 extends in the longitudinal direction from the front end face of the tube body 51 and shows a hexagon along the outer shape of the tube body 51 viewed from the viewpoint along the center line 102. [ The groove 54 is inserted with the convex piece 58 of the cell harvesting member 52. The depth along the center line 102 of the groove 54 is about the same as the dimension at which the convex piece 58 protrudes from the main body 55 along the centerline 102 in the cell harvesting member 52. [

[Cell harvesting member (52)]

9 and 12, the cell harvesting member 52 has a main body 55 and a brush 56. As shown in Fig. The main body 55 is, for example, a molded product of synthetic resin. The brush 56 is inserted into a hole 57 formed at the tip end side of the main body 55 and fixed by an adhesive or the like. The brush 56 has a plurality of synthetic resin fibers fixed on a shaft made of stainless steel. The structure or shape of the brush 56 may be any known one such as a molded article of an elastomer. Therefore, as in this embodiment, the shaft extends along the center line 102 of the tubular body 51, the fibers may be radially extended from the shaft, or other shapes may be employed.

The main body 55 has a substantially hexagonal columnar outer shape. A convex piece 58 protruding from the surface of the body 55 is provided on the base end side of the body 55. The convex piece 58 protrudes along the center line 102 from the base end side of the main body 55 and shows a hexagonal shape as viewed from the viewpoint along the center line 102. [ The dimension at which the convex piece 58 protrudes from the main body 55 along the center line 102 is approximately the same as the dimension along the center line 102 of the male thread portion 61 of the operation member 53 described later. The thickness of the convex piece 58 is set so as to be insertable into the groove 54 of the tube 51. The convex piece 58 is inserted into the groove 54 of the tubular body 51 and the base end surface of the tubular body 51 and the surface of the base end of the tubular body 51 abut each other, 51 at the positions where their respective axes coincide with each other. The main body 55 does not rotate in the rotational direction 103 with respect to the tubular body 51 by the fitting of the convex piece 58 and the groove 54. [ The groove 54 and the convex piece 58 correspond to the fitting portion.

A threaded hole 59 extending toward the distal end side along the center line 102 is formed on the inner side of the convex piece 58 on the base end side of the main body 55. The screw hole 59 has a cylindrical shape and is screwed to the male threaded portion 61 of the operation member 53, which will be described later. The depth along the center line 102 of the screw hole 59 is about the same as the dimension along the center line 102 of the male screw portion 61 of the operating member 53 described later.

(Operation member 53)

10 and 12, the operating member 53 has a rod portion 60, a male screw portion 61, and a handle portion 62. As shown in Figs. The rod portion 60 is a substantially columnar member elongated in the longitudinal direction 101. The rod portion 60 has an outer diameter that can be inserted into the inner space of the tubular body 51 and the length of the longitudinal direction 101 is slightly longer than the length of the tubular body 51 in the longitudinal direction 101.

On the tip end side of the operating member 53, a male threaded portion 61 is provided. The male screw portion 61 is integrally formed on the distal end side of the rod portion 60. [ The male screw portion 61 can be screwed into the screw hole 59 of the cell harvesting member 52. The male threaded portion 61 corresponds to the locking portion and the threaded portion. The posture in which the male screw portion 61 is screwed into the screw hole 59 corresponds to the locking posture and the posture in which the male screw portion 61 has escaped from the screw hole 59 corresponds to the release posture.

At the base end of the rod portion (60), a handle portion (62) is provided. The grip portion 62 is in the shape of a hexagonal column having an outer diameter larger than the outer diameter of the rod portion 60 and the inner diameter of the tube body 51. [ The outer diameter of the rod portion 60 is slightly smaller than the inner diameter of the tubular body 51.

[Use of cell harvesting device 50]

The cell harvesting apparatus 50 is configured such that the cell harvesting member 52 is attached to the tubular body 51 and the male threaded portion 61 of the operating member 53 is screwed into the screw hole 59, To be used in a state of being screwed on. The cell collection member 52 is fixed with respect to the tubular body 51 in the longitudinal direction 101 and the rotation direction 103 when the male screw portion 61 is in the locking posture. Therefore, when the operator grips the proximal end side of the tubular body 51 and performs manipulation such as pushing and pulling or rotating, the force is transmitted to the cell harvesting member 52 so that the cell harvesting member 52 moves integrally with the tubular body 51 Or rotate.

The convex piece 58 of the cell harvesting member 52 and the groove 54 of the tubular body 51 are fitted to each other with the cell collecting member 52 mounted on the tip of the tubular body 51, do. Therefore, the cell-gathering member 52 does not rotate in the rotating direction 103 with respect to the tube body 51. The operating member 53 is inserted from the base end and the male screw portion 61 of the operating member 53 is screwed into the screw hole 59 of the cell harvesting member 52. [ Therefore, the cell harvesting member 52 does not move in the longitudinal direction 101 with respect to the tube body 51.

After the cervical cells are collected, as shown in Fig. 13, the proximal end of the tubular body 51 and the handle portion 62 of the operating member 53 are held by the practitioner so that the handle portion 62 is held in the tubular body 51 . As a result, the male threaded portion 61 of the operating member 53 is disengaged from the screw hole 59 of the cell harvesting member 52. The cell collecting member 52 attached to the distal end of the tubular body 51 is moved in the longitudinal direction 101 of the tubular body 51 along the gravity direction with the cell harvesting member 52 downward, And easily escapes from the tubular body 51. The missing cell collecting member 52 is accommodated in a storage container (not shown).

The operating member 53 is moved by the user so that the relative position along the center line 102 of the tubular body 51 and the operating member 53 does not change when the handle portion 62 is rotated relative to the tubular body 51 The threaded portion 61 of the operating member 53 is disengaged from the screw hole 59 of the cell harvesting member 52 and the cell collecting member 52 is separated from the distal end of the tubular body 51, The convex piece 58 exits from the groove 54. The dimension along the center line 102 of the convex piece 58 and the dimension along the center line 102 of the male screw portion 61 are equal to each other so that the distance between the male screw portion 61 and the male screw portion 61 When the male screw portion 61 comes out of the screw hole 59, the male screw portion 58 and the groove 54 are engaged with each other and the convex portion 58 comes out of the groove 54, ).

According to the second embodiment, the same operational effects as those of the first embodiment can be obtained.

The rotation of the tubular body 51 is transmitted to the cell collection member 52 by fitting the groove 54 of the tubular body 51 and the convex piece 58 of the cell collection member 52, The threaded hole 59 of the body 52 and the threaded portion 61 of the operating member 53 or the tip of the tube 51 and the body 55 of the cell- The force is transmitted in the direction in which the cell collection member 52 is separated from the tubular body 51. [ Since the force is transmitted from the tubular body 51 to the cell harvesting member 52 by such fitting and screwing, the load on each member constituting the cell harvesting apparatus 50 is reduced.

[Third Embodiment]

The cell harvesting apparatus 70 according to the third embodiment differs from the cell harvesting apparatus 50 according to the second embodiment in that a connecting hole 71 is formed in place of the screw hole 59 of the cell harvesting member 52 And the engaging portion 72 is provided instead of the male screw portion 61 of the operating member 53. The other structures are the same. Hereinafter, the engaging hole 71 and the engaging portion 72 will be described in detail. In the cell harvesting apparatus 70, the members having the same reference numerals as the cell harvesting apparatus 50 according to the second embodiment are the same members as the cell harvesting apparatus 50.

14 and 15, in the inside of the convex piece 58 on the base-end side of the main body 55 of the cell-gathering member 52, an engaging hole (not shown) extending toward the tip side along the center line 102 71 are formed. The engaging hole 71 is substantially cylindrical. The convex portions 73 and 74 protruding in the direction of narrowing the opening, that is, the inward direction approaching the center line 102, are provided symmetrically with respect to the center line 102 at the opening perimeter of the engaging hole 71 . The convex portions 73 and 74 protrude so as to narrow the inner diameter of the engaging portion 71. [ A space continuous to the inside of the engaging hole 71 (the tip end side of the main body 55) is formed between the convex portions 73 and 74.

An engaging portion 72 is provided at the tip end side of the operating member 53. [ The engaging portion 72 is integrally formed on the distal end side of the rod portion 60. The engaging portion 72 has a small-diameter portion 75 and a blade piece 76, 77. The small diameter portion 75 has an outer diameter smaller than the outer diameter of the rod portion 60 and is capable of entering along the center line 102 between the convex portions 73 and 74 of the engaging hole 71. On the leading end side of the small diameter portion 75, blade pieces 76 and 77 are provided symmetrically with respect to the center line 102 as a center. The blade pieces 76 and 77 protrude outwardly from the center line 102, respectively. The blade pieces 76 and 77 are each in the shape of a partial circle and are of a size and shape capable of entering into the space between the convex portions 73 and 74 of the engaging hole 71. The surfaces of the blade pieces 76 and 77 on the side of the rod portion 60 are inclined surfaces 78 and 79 that are inclined in a direction approaching the rod portion 60. The blade pieces 76 and 77 enter the engaging hole 71 and are engageable with the convex portions 73 and 74.

[Use of cell harvesting device 70]

The convex piece 58 of the cell harvesting member 52 and the groove 54 of the tubular body 51 are fitted to each other with the cell collecting member 52 mounted on the tip of the tubular body 51, do. Therefore, the cell-gathering member 52 does not rotate in the rotating direction 103 with respect to the tube body 51. The operating member 53 is inserted from the base end and the engaging portion 72 of the operating member 53 is engaged with the engaging hole 71 of the cell harvesting member 52. [

More specifically, as shown in Fig. 16, when the engaging portion 72 and the blade piece 76 are engaged with the convex portions 73, 74 of the engaging hole 71 The member 53 is positioned. The engaging portion 72 of the operating member 53 inserted into the tubular body 51 from the proximal end side of the tubular body 51 at the second rotational position is in contact with the convex portions 73, (Toward the front end side) of the engaging hole 71 through the space between them. 15, when the operating member 53 is rotated from the second rotation position to the first rotation position, the blade pieces 76 and 77 move to the positions where they contact the convex portions 73 and 74. [ The inclined surfaces 78 and 79 of the blade pieces 76 and 77 come into contact with the convex portions 73 and 74 and are guided by the inclined surfaces 78 and 79 so that the engaging portions 72 are engaged with the engaging portions 71 It touches the inner side. As a result, the operating member 53 can not rotate beyond the first rotational position. The cell collecting member 52 does not move in the longitudinal direction 101 with respect to the tubular body 51 due to the engagement between the engaging portion 72 and the engaging hole 71. [ The engaging portion 72 at the first rotational position is in the lock posture and the engaging portion 72 at the second rotational position is the release posture.

16, the proximal end side of the tubular body 51 and the handle portion 62 of the operating member 53 are held by the practitioner so that the handle portion 62 is held by the tubular body 51, To the second rotation position. The engaging portion 72 of the operating member 53 is disengaged from the engaging hole 71 of the cell harvesting member 52 when the handle portion 62 is slightly separated from the tubular body 51. [ The cell collection member 52 attached to the distal end of the tubular body 51 is easily moved by the gravity when the longitudinal direction 101 of the tubular body 51 is in the state of gravity along the cell collecting member 52 downward And is removed from the tubular body 51. The missing cell collecting member 52 is accommodated in a storage container (not shown).

According to the third embodiment, the same operational effects as those of the second embodiment can be obtained.

In order to rotate the operating member 53 to the first rotational position or the second rotational position, since the knob portion 62 of the operating member 53 is only rotated by about 90 degrees, the engaging portion 72 The posture changes.

[Fourth Embodiment]

17, the cell harvesting apparatus 80 has a tubular body 81, a cell harvesting member 82, an operating member 83, and a cap 84. As shown in Fig. The cell harvesting member 82 is detachably mounted on the distal end side of the tubular body 81. The cell harvesting member 82 is inserted into the tube 81. The cap 84 is mounted on the base end side of the tubular body 81. In the present embodiment, the direction in which the elongated tubular body 81 extends is referred to as the longitudinal direction 101. An imaginary line passing through the center of the tube 81 along the longitudinal direction 101 is referred to as a center line 102. The direction of rotation about the center line 102 is referred to as the rotation direction 103. [ 17), and the side on which the cell harvesting member 82 is mounted is referred to as a distal end side (left side in Fig. 17). The tip of the tube 81 corresponds to the first end, and the base end of the tube 81 corresponds to the second end.

[Tubular body 81 and cap 84]

As shown in Figs. 17 and 18, the tube body 81 is a member having a long and thin cylindrical shape in the longitudinal direction 101. The tubular body 81 has a front end and a rear end respectively opened, and a circular inner space is continuous between the front end and the rear end. The tube body 81 is formed, for example, as a molded product of a synthetic resin. The material and shape of the tubular body 81 are not particularly limited, and may be polygonal, for example. The external dimension of the tubular body 81 and the length of the longitudinal direction 101 are set so as to be most suitable for the operator to hold the proximal end side and to allow the cell harvesting member 82 to reach the cervical portion.

A male threaded portion 85 is provided on the outer peripheral surface of the base end side of the tubular body 81. A cap 84 is mounted on the male threaded portion 85. The cap 84 is cylindrical in shape to cover the base end side of the tubular body 81 and also closes the opening at the base end side of the tubular body 81. 21, a female screw portion 86 is formed on the inner peripheral surface of the cap 84. As shown in Fig. The female screw portion 86 and the male screw portion 85 are screwed together so that the base end of the tube body 81 is covered by the cap 84 and closed.

As shown in Fig. 21, a groove 87 is provided on the surface of the tube 81 on the tip side. The groove 87 extends in the longitudinal direction on the front end side of the tubular body and shows a circular shape along the outer shape of the tubular body 51 as viewed from the viewpoint along the center line 102. [ In the groove 87, the convex piece 91 of the cell harvesting member 82 is inserted.

As shown in Fig. 21, a large-diameter portion 95 having an expanded inner diameter is formed at the distal end side of the tube 81. As shown in Fig. The large-diameter portion 95 is formed slightly on the proximal end side of the tip of the tubular body 81. The large-diameter portion 95 is a shape in which the central portion of the longitudinal direction 101 has the largest inner diameter, and has a tapered shape with its inner diameter reduced toward the tip end side and the base end side.

[Cell harvesting member (82)]

19 and 21, the cell harvesting member 82 has a main body 88 and a brush 89. As shown in Fig. The main body 88 is, for example, a molded product of synthetic resin. The brush 89 is inserted into a hole 90 formed in the front end side of the main body 88 and fixed with an adhesive or the like. The brushes 89 are formed by fixing a plurality of synthetic resin fibers on a shaft made of stainless steel. The structure or shape of the brush 89 may be any known one such as a molded article of an elastomer. Therefore, as in this embodiment, the shaft extends along the center line 102 of the tube 81, and the fibers may be radially extended from the shaft, or other shapes may be employed.

The main body 88 has a substantially cylindrical outer shape. A convex piece 91 protruding from the surface of the body 88 is provided on the base end side of the body 88. The convex piece 91 protrudes along the center line 102 from the base end side of the main body 88 and shows a circular shape when viewed along the center line 102. [ The thickness of the convex piece 91 is set so as to be insertable into the groove 87 of the tube body 81. [ The convex piece 91 is inserted into the groove 87 of the tubular body 81 and the base end side face of the body 88 and the front end side face of the tubular body 81 come into contact with each other, ) At the positions where the respective axes coincide with each other.

The elastic pieces 92 and 93 are protruded from the base-end side surface on the inner side of the convex piece 91 on the base end side of the main body 88. The elastic pieces 92 and 93 are each in the form of a thin plate capable of being elastically deformed, and are arranged at positions where the front and back surfaces are parallel to each other and are symmetrical with respect to the center line 102.

In the elastic pieces 92 and 93, the distance between the position farthest from the center line 102 is shorter than the inner diameter of the tube body 81. [ The elastic pieces 92 and 93 can easily enter and exit the opening of the front end of the tube 11 in a state where the elastic pieces 92 and 93 are not elastically deformed. The elastic pieces 92 and 93 correspond to the deformed portion.

Between the elastic pieces 92 and 93 on the base end side of the main body 88, a hole 94 is formed extending along the center line 102 to the tip side. The hole 94 is cylindrical, and a locking portion 96 of the operation member 83, which will be described later, is inserted.

(Operation member 83)

As shown in Figs. 20 and 21, the operating member 83 is a substantially quadrangular prism member elongated in the longitudinal direction 101. The operating member 83 is an outer diameter that can be inserted into the inner space of the tube body 81 and the length of the longitudinal direction 101 is slightly longer than the length of the tube body 81 in the longitudinal direction 101.

A lock portion 96 is provided on the tip end side of the operating member 83. [ The lock portion 96 is provided with a pair of elastically deformable portions 88 opposing each other via a slit 99 passing through the operating member 83 in the direction perpendicular to the longitudinal direction 101 at the tip end side of the operating member 83 97, and 98, respectively. The elastic deforming parts 97 and 98 are curved outwardly in the state where no external force is applied. When the compressive force along the longitudinal direction 101 is applied to the lock portion 96, the elastic deformation portions 97 and 98 are elastically deformed to warp outward largely. The elastic deforming portion 97 is formed with a slot 100 along the longitudinal direction 101 to facilitate deformation. The same elongated hole 100 is formed in the elastic deforming portion 98 as well.

[Use of cell harvesting device 80]

The cell harvesting apparatus 80 is configured such that the cell harvesting member 82 is attached to the tubular body 81 and the operating member 83 is inserted into the tubular body 81 and the tubular body 81 Is closed by the cap 84. [0052] As shown in Fig. In this state, the locking portion 96 is in the locking posture. In the locking posture, the cell harvesting member 82 is fixed with respect to the tubular body 81 in the longitudinal direction 101 and the rotation direction 103. Therefore, when the operator grips the proximal end side of the tubular body 81 and performs an operation such as pushing, pulling, or rotating, the force is transmitted to the cell harvesting member 82 so that the cell harvesting member 82 moves integrally with the tubular body 81 Rotate.

21, when the operation member 83 is inserted from the base end of the tubular body 81 in a state where the cell harvesting member 82 is attached to the tip of the tubular body 81, The large-diameter portion 95 of the main body 100 reaches. The distal end of the lock portion 96 enters the hole 90 of the cell harvesting member 82 and the elastic deformation portions 97 and 98 are located inside the elastic pieces 92 and 93 of the cell harvesting member 82 . In this state, the proximal end side of the operating member 83 protrudes outward from the base end of the tubular body 81.

The base end side of the operating member 83 protruding from the base end of the tubular body 81 is pushed into the inner space of the tubular body 81 by screwing the cap 84 to the male threaded portion 85 of the tubular body 81. [ The elastic deformed portions 97 and 98 of the lock portion 96 are pushed against the inner wall of the large diameter portion 95 via the elastic pieces 92 and 93 in the large diameter portion 95 of the tube body 81 And a compressive force in the longitudinal direction 101 is applied to the lock portion 96. The elastic deformation portions 97 and 98 are elastically deformed outward by the compressive force to elastically deform the elastic pieces 92 and 93 between the inner and outer walls. That is, the elastic deformation portions 97 and 98 elastically deform the elastic pieces 92 and 93 outwardly, thereby pressing the elastic pieces 92 and 93 against the inner wall of the large-diameter portion 95.

The resilient pieces 92 and 93 are sandwiched between the lock portion 31 and the inner wall of the large diameter portion 95 of the tube body 11 Do not move along the direction 101 or rotate along the direction of rotation 103. [ Thus, the posture (the position in the longitudinal direction 101) of the lock portion 96 elastically deforming the elastic pieces 92 and 93 corresponds to the lock posture.

After the cervical cells are collected, the cap 84 is separated from the tube 81 by the practitioner as shown in Fig. As a result, the compressive force applied to the lock portion 96 is lost, and the elastic deformation portions 97 and 98 return to their original state. As the operating member 83 is moved in the direction of withdrawing from the base end of the tubular body 81, the locking portion 96 is drawn out of the large-diameter portion 95 and the elastic deformation portions 97 and 98 are pulled out from the cell- The elastic pieces 92 and 93 are separated from each other. The posture (in this embodiment, the position in the longitudinal direction 101) of the lock portion 96 in which the elastic pieces 92 and 93 are not elastically deformed corresponds to the release posture.

The elastic pieces 92 and 93 returned to the original state can easily enter and exit the opening of the front end of the tube body 81. [ The cell harvesting member 82 attached to the distal end of the tubular body 81 can be moved in the direction of gravity along the longitudinal direction 101 of the tubular body 81 with the cell harvesting member 82 downward, So that it can be easily removed from the tubular body 81. The missing cell harvesting member 82 is accommodated in a storage container (not shown).

According to the fourth embodiment, the same operational effects as those of the first embodiment can be obtained.

In this embodiment, the cap 84 is screwed into the male threaded portion 85 of the tubular body 81 so that the compression force is applied to the lock portion 96. However, the male threaded portion 85 and the female threaded portion 86, The cap 84 may be engaged with the base end side of the tubular body 81 to make it impossible to move in the longitudinal direction 101. [

The elastic pieces 92 and 93 of the cell harvesting member 82 are pressed against the inner wall of the tubular body 81 in a state where the elastic deformation portions 97 and 98 of the operating member 83 are elastically deformed The elastic deformation portions 97 and 98 of the operating member 83 are widened as the operating member 83 is moved in the pulling direction from the tube body 81, The lock portion 96 may be changed from the locked position to the unlocked position by being pushed into the tubular body 81 by the operation member 83 being pushed into the tapered state.

More specifically, as shown in Fig. 23, the elastic deformation portions 97 and 98 are resiliently returned in a state in which the lock portion 96 is located in the large-diameter portion 95, and the elastic deformation portions 97, 98 to the inner wall of the large-diameter portion 95. The elastic pieces 92 and 93 do not move along the longitudinal direction 101 with respect to the tube body 81 or rotate along the rotation direction 103. [ Although not shown in the drawings, the operation member 83 is configured such that the spacer 104 or the like is provided on the base end side of the tubular body 81 or engaged with the tubular body 81 so as not to be pushed into the tubular body 81 .

The above-described spacers are separated or disengaged, so that the operating member 83 can be pushed into the tube 81. [ 24, the distal end of the lock portion 96 is moved into the hole 94 of the cell harvesting member 82 and the elastic deformation portions 97, 98 are elastically deformed so as to narrow the gap. As a result, the elastic pieces 92 and 93 are resiliently returned to be able to escape from the large-diameter portion 95 of the tube body 81. The cell collecting member 82 is separated from the distal end of the tube 81 by pressing the cell collecting member 82 by abutting the tip of the lock portion 96 against the end surface of the hole 94.

According to this modified example, the same operational effects as those of the fourth embodiment can be obtained.

[Fifth Embodiment]

As shown in Fig. 25, the cell collection device 110 has a tube 111, a cell collection member 112, an operation member 113, and a lock member 114. As shown in Fig. The cell collecting member 112 is detachably mounted on the distal end side of the tube 111. The operating member 113 is inserted into the tube 111. The locking member 114 is embedded in the tubular body 111 and engaged with the cell harvesting member 112. In this embodiment, the direction in which the elongated tubular body 111 extends is referred to as the longitudinal direction 101. An imaginary line passing through the center of the tube 111 along the longitudinal direction 101 is referred to as a center line 102. The direction of rotation about the center line 102 is referred to as the rotation direction 103. [ The side on which the operator holds the tubular body 111 is referred to as a proximal side (right side in FIG. 25), and the side on which the cell collection member 112 is mounted is referred to as a distal side (left side in FIG. 25). The tip of the tube 111 corresponds to the first end, and the base end of the tube 111 corresponds to the second end.

[Tubular body (111)]

As shown in Figs. 26 and 29, the tubular body 111 is a member having a long tubular shape elongated in the longitudinal direction 101. The tubular member 111 has a front end and a rear end respectively opened, and an inner space is continuous between the front end and the rear end. The tube body 111 is formed, for example, as a molded product of a synthetic resin. The material and shape of the tubular body 111 are not particularly limited, and may be polygonal, for example. The external dimensions of the tubular body 111 and the length of the longitudinal direction 101 are set so as to be best suited for the operator to reach the base end side and to allow the cell collection member 112 to reach the cervical portion.

29, a seat portion 119 for positioning the cell-gathering member 112 is provided at the distal end side of the inner space of the tube 111. [ The seat portion (119) has a through hole (120) along the center line (102).

[Cell harvesting member (112)]

27 and 29, the cell harvesting member 112 has a main body 115 and a brush 116. As shown in Fig. The main body 115 is, for example, a molded product of synthetic resin. The brush 116 is inserted into a hole 117 formed in the front end side of the main body 115 and fixed with an adhesive or the like. The brush 116 has a plurality of synthetic resin fibers fixed on a shaft made of stainless steel. The structure or shape of the brush 116 may be any known one such as a molded article of an elastomer. Therefore, as in this embodiment, the axis extends along the center line 102 of the tube 111, the fibers may be radially extended from the axis, or other shapes may be employed. In Fig. 27, the brush 116 is omitted.

The main body 115 has a substantially conical outer shape. The outer diameter of the base end side of the main body 115 is slightly smaller than the inner diameter of the tubular body 111. Therefore, the main body 115 can enter the inner space from the tip end of the tube 111. An engaging portion 118 protruding from the surface along the center line 102 is provided on the base end side of the main body 115. The engaging portion 118 has a substantially cylindrical shape, and a brush-shaped engaging piece 129 is formed at the projecting end thereof to widen the outer diameter. The engaging portion 118 is an external dimension that can be inserted into the through hole 120 of the seat portion 119 of the tube 111.

When the main body 115 is inserted into the internal space at the front end of the tubular body 111, the engaging portion 118 passes through the through hole 120 of the seat portion 119 and the base- (119). As a result, the main body 115 is positioned and mounted at the tip of the tube 111.

(Operation member 113)

As shown in Figs. 26 and 29, the operating member 113 is a member having a long and slender shape in the longitudinal direction 101 and a circular tube shape. The operating member 113 is an outer diameter that can be inserted into the inner space of the tube 111. The length of the operating member 113 in the longitudinal direction 101 is slightly shorter than the length in the longitudinal direction 101 of the tube 111. [ The distal end of the operating member 113 is open, and a tapered guide surface 121 is provided on the inner circumferential surface side of the circumferential edge to widen the inner diameter.

At the base end of the operating member 113, a flange portion 122 projecting outwardly away from the center line 102 is provided. The outer diameter of the flange portion 122 is larger than the inner diameter of the tubular body 111. The operation member 113 inserted from the proximal end side of the tubular body 111 is further prevented from being inserted by the flange portion 122 abutting the proximal end of the tubular body 111. [

[Locking member 114]

As shown in Figs. 28 and 29, the lock member 114 has an outer cylinder portion 123 and a pinch portion 124. As shown in Fig. The outer cylinder 123 is a cylindrical shape in which a space for operating the pinch portion 124 is cut. The outer tube 123, which is spaced apart, is connected by a connecting portion 132. The outer diameter of the outer tube 123 is smaller than the inner diameter of the tube 111. The outer diameter of the outer tube 123 is set so as to be in contact with the seat 119 of the tube 111. The lock member 114 inserted into the inner space from the base end side of the tube 111 is positioned with respect to the tip direction by abutting the outer tube portion 123 against the seat portion 119. [

The pinch portion 124 is connected to the base end side of the outer cylinder 123. The pinch portion 124 is capable of changing the posture such that the pair of flat plate members 125 and 126 are rotated by the elastic deformation of the connecting portion of the outer cylinder 123 and the connecting portion 132. [ The pair of the flat plate members 125 and 126 becomes an attitude in which the proximal end side is relatively widened with respect to the distal end side in the state where no external force is applied. Claw portions 127, 128 projecting in the opposite directions are formed on the tip end sides of the flat plate members 125, 126, respectively. The claw portions 127 and 128 are fitted into the proximal end side of the main body 115 from the engaging piece 129 of the engaging portion 118 of the cell harvesting member 112 and are engageable with the engaging portion 118 .

[Coil springs (130, 131)]

A coil spring 130 (not shown) is inserted into a space between the pair of flat plate members 125 and 126 at the tip end side of the connecting portion 132 in an assembled state in which the lock member 114 is inserted into the tube 111, Are assembled with the longitudinal direction 101 in the compression direction. The coil spring 130 allows the pinch portion 124 to be engaged with the engaging piece 129 of the engaging portion 118 while being engaged with the engaging portion 118 of the main body 115 of the cell harvesting member 112 And is held in the compressed state between the connecting portions 132 of the locking member 114. [

A coil spring 131 is disposed between the lock member 114 and the operating member 113 with the longitudinal direction 101 in the compression direction. The coil spring 131 is elastically supported in such a direction as to abut the distal end of the outer cylinder 123 of the lock member 114 and the operating member 113 and to pull the operating member 113 out of the base end of the tube 111. [ The guide surface 121 of the operating member 113 resiliently supported by the coil spring 131 comes into contact with or near the base end of the flat plate members 125 and 126 of the lock member 114. [ In this state, the flat plate members 125 and 126 do not receive sufficient force to change the posture from the operating member 113, and the proximal end side is held in a posture relatively widened with respect to the distal end side. At this time, the posture of the lock member 114 corresponds to the lock posture.

[Use of cell collection device 110]

The cell harvesting apparatus 110 may be configured such that the cell harvesting member 112 is attached to the tubular body 111 and the operating member 113 is attached to the locking member 114 and the cell harvesting member 112 Is in a locking posture in which the engaging portion 118 is engaged. The main body 115 is pressed against the seat portion 119 by the engagement of the lock member 114 and the engagement portion 118 of the cell collection member 112 so that the cell- Is fixed with respect to the direction (101) and the rotation direction (103). Therefore, when the practitioner grips the proximal end side of the tubular body 111 and pushes or pulls or rotates the tubular body 111, the force is transmitted to the cell harvesting member 112 so that the cell harvesting member 112 moves or moves integrally with the tubular body 111 Rotate.

The lock member 114, the coil spring 130, the coil spring 131, and the coil spring 131 are attached from the base end side of the tube body 111 in a state where the cell collection member 112 is mounted on the tip of the tube body 111, , And the operating member 113 are inserted in this order. The pawl portions 127 and 128 of the flat plate members 125 and 126 of the locking member 114 are engaged with the engaging portion 118 of the cell harvesting member 112 inserted into the through hole 120 of the seat portion 119 The guide surface 121 of the operating member 113 abuts against the base end of the flat plate members 125 and 126 when the operating member 113 is pushed into the tube 111 against the elastic supporting force of the coil spring 131, And the base ends of the flat plate members 125 and 126 are guided along the guide surface 121 in the direction of narrowing the gap. The leading end side of the flat plate members 125 and 126 widens and the gap between the claw portions 127 and 128 becomes larger than the outer diameter of the engaging piece 129 of the engaging portion 118. [

When the operation member 113 is further pushed into the tubular body 111 in a state where the cell collection member 112 is fixed so as not to come out from the tubular body 111 in order to resist the elastic supporting force of the coil spring 130, 130 are compressed and deformed to move the lock member 114 until the lock member 114 abuts on the seat portion 119. [ Thereafter, when the pushing of the operating member 113 is stopped, the operating member 113 is moved in the direction in which the operating member 113 is pulled out of the tube 111 by the elastic supporting force of the coil spring 130. The guide surface 121 of the operating member 113 also moves toward the proximal end side of the tube 111. [ The flat plate members 125 and 126 are resiliently returned to the proximal end side in the posture relatively widened relative to the distal end side so that the claw portions 127 and 128 are engaged with the engaging portion 118 of the cell- The lock member 114 and the engaging portion 118 are engaged with each other. The cell collecting member 112 is held in a state in which it is mounted on the distal end side of the tubular body 111 against the elastic supporting force of the coil spring 131 by this engagement.

The operator pushes the flange 122 of the operating member 113 toward the proximal end side of the tube 111 against the elastic supporting force of the coil spring 131 as shown in Fig. The operating member 113 is pushed into the tube 111 and the guide surface 121 of the operating member 113 slides against the base ends of the flat plate members 125 and 126 and moves along the guide surface 121 The base ends of the flat plate members 125 and 126 are guided in the direction to narrow the gap. The leading end side of the flat plate members 125 and 126 widens and the gap between the claw portions 127 and 128 becomes larger than the outer diameter of the engaging piece 129 of the engaging portion 118. [ That is, the engaging portion 118 and the lock member 114 are disengaged from each other. At this time, the posture of the lock member 114 corresponds to the release posture.

When the deflection fitting portion 118 and the locking member 114 are disengaged from each other, the cell collection member 112 is pulled out from the distal end of the tubular body 111 by the elastic supporting force of the coil spring 130. The extracted cell-harvesting member 112 is accommodated in a storage container (not shown).

According to the fifth embodiment, the same operational effect as that of the first embodiment can be obtained.

[Sixth Embodiment]

As shown in Fig. 31, the cell collection device 150 has a tubular body 151, a cell collection member 152, and an operation member 153. The cell harvesting member 152 is detachably attached to the distal end side of the tube 151. The operating member 153 is inserted into the tube 151. In the present embodiment, the direction in which the elongated tubular body 151 extends is referred to as the longitudinal direction 101. An imaginary line passing through the center of the tube 151 along the longitudinal direction 101 is referred to as a center line 102. The direction of rotation about the center line 102 is referred to as the rotation direction 103. [ 31), and the side on which the cell harvesting member 152 is mounted is referred to as a distal end side (left side in Fig. 31). The tip of the tube 151 corresponds to the first end, and the base end of the tube 151 corresponds to the second end.

[Body (151)]

31 and 32, the tubular body 151 is a cylindrical tubular member whose outer shape is elongated in the longitudinal direction 101 and which is shaped like a cylinder. The tubular body 151 has a front end and a rear end respectively opened, and a circular inner space is continuous between the front end and the rear end. The tube body 151 is formed, for example, as a molded product of a synthetic resin. The material and shape of the tubular body 151 are not particularly limited, and may be, for example, a prismatic shape. The external dimension of the tubular body 151 and the length of the longitudinal direction 101 are set so as to be best suited for the proximal end side to reach the cell collecting member 152 to the cervical portion.

As shown in Figs. 35 and 36, grooves 154 are provided on the surface of the tube 151 on the tip side. The groove 154 extends in the longitudinal direction from the front end side of the tube 151 and shows a hexagon along the outer shape of the tube 151 as seen from the viewpoint along the center line 102. [ The groove 154 is inserted with the convex piece 158 of the cell harvesting member 152. The depth along the center line 102 of the groove 154 is about the same as the dimension at which the convex piece 158 protrudes from the body 155 along the centerline 112 in the cell harvesting member 152. [

As shown in FIGS. 32 and 36, a large-diameter portion 166 having a large inner diameter is provided on the inner surface of the base end side of the tube 151. The large-diameter portion 166 extends in the longitudinal direction from the opening on the base end side of the tubular body 151. In the large-diameter portion 166, a bulge portion 167 is provided at the base end side of the tube body 151. Four swelling portions 167 are arranged at intervals in the circumferential direction of the inner surface of the tube body 151. Each swollen portion 167 and the step portion 168 at the leading end of the large-diameter portion 166 are apart from each other in the longitudinal direction. The flange portion 163 of the operating member 153 is inserted into the large-diameter portion 166 to engage with the respective bulging portions 167.

[Cell harvesting member (152)]

33 and 36, the cell harvesting member 152 has a main body 155 and a brush 156. As shown in Fig. The main body 155 is, for example, a molded product of synthetic resin. The brush 156 is inserted into a hole 157 formed at the tip end side of the main body 155 and is fixed with an adhesive or the like. The brush 156 is formed by fixing a plurality of synthetic resin fibers on a shaft made of stainless steel. The structure or shape of the brush 156 may be any known one such as a molded article of an elastomer. Therefore, as in this embodiment, the shaft extends along the center line 102 of the tubular body 151, the fibers may be radially extended from the shaft, or other shapes may be employed.

The main body 155 has a substantially cylindrical outer shape. A convex piece 158 protruding from the surface of the body 155 is provided on the base end side of the body 155. The convex piece 158 protrudes along the center line 102 from the base end side of the main body 155 and shows a hexagonal shape when viewed along the center line 102. [ The dimension at which the convex piece 158 protrudes from the main body 155 along the center line 102 is the same as the dimension along the center line 102 of the male thread portion 161 of the operation member 153 described later.

The thickness of the convex piece 158 is set so as to be insertable into the groove 154 of the tube 151. [ The convex piece 158 has a tapered shape in which the thickness of the convex piece 158 decreases from the main body 155 toward the leading end. The convex piece 158 is inserted into the groove 154 of the tube body 151 and the surface 169 of the base end side of the body 155 and the tip side surface of the tube body 151 abut each other, And is positioned and mounted at a position where the respective axes coincide with the tip of the tube 151. The main body 155 does not rotate in the rotational direction 103 with respect to the tube body 151 by the fitting of the convex piece 158 and the groove 154. [ The groove 154 and the convex piece 158 correspond to the fitting portion.

A threaded hole 159 is formed on the inner side of the convex piece 158 on the base end side face 169 of the main body 155 so as to extend along the center line 102 to the tip side. The screw hole 159 has a cylindrical shape and is screwed to the male screw portion 161 of the operation member 153, which will be described later. The depth along the center line 102 of the screw hole 159 is about the same as the dimension along the center line 102 of the male screw portion 161 of the operation member 153 described later.

[Operation member 153]

34 and 36, the operating member 153 has a rod portion 160, a male screw portion 161, a handle portion 162, and a flange portion 163. The rod portion 160 is a substantially columnar member elongated in the longitudinal direction 101. The rod portion 160 is an outer diameter that can be inserted into the inner space of the tube body 151 and the length of the longitudinal direction 101 is slightly longer than the length of the tube body 151 in the longitudinal direction 101.

A male threaded portion 161 is provided at the tip end side of the operating member 153. The male screw portion 161 is integrally formed on the tip end side of the rod portion 160. [ The male screw portion 161 enters the screw hole 159 of the cell harvesting member 152 and is screwable. And the male threaded portion 161 corresponds to the lock portion and the threaded portion. The posture in which the male screw portion 161 is screwed into the screw hole 159 corresponds to the locking posture and the posture in which the male screw portion 161 has escaped from the screw hole 159 corresponds to the release posture.

A handle 162 is provided at the base end of the rod 160. The handle portion 162 has a star-shaped cross section having a minimum outer diameter larger than the outer diameter of the rod portion 160 and the inner diameter of the tube body 151. The outer diameter of the rod portion 160 is slightly smaller than the inner diameter of the tubular body 151.

A flange portion 163 is provided at the base end side of the rod portion 160 with a distance from the handle portion 162 toward the tip end side. The flange portion 163 protrudes outward from the outer peripheral surface of the rod portion 160 and continues along the outer peripheral surface of the rod portion 160. The surface 164 on the tip side of the flange portion 163 is an inclined surface facing away from the center line 102 and the base surface 165 of the flange portion 163 is orthogonal to the center line 102. [ A space is provided between the face 165 and the handle portion 162 so that the swelled portion 167 of the tube 151 can be disposed. The outer diameter of the flange portion 163 is smaller than the diameter of the large diameter portion 166 of the tubular body 151 and the distance between the tip end of the bulged portion 167 and the outer diameter of the inner space other than the large diameter portion 166 of the tubular body 151 Diameter.

[Use of cell collection device 150]

The cell harvesting apparatus 150 may be configured such that the cell harvesting member 152 is attached to the tubular body 151 and the male threaded portion 161 of the operating member 153 is screwed into the screw hole 159, To be used in a state of being screwed on. The cell collection member 152 is fixed with respect to the tubular body 151 in the longitudinal direction 101 and the rotation direction 103 when the male thread portion 161 is in the locking posture. Therefore, when the practitioner grips the proximal end side of the tubular body 151 and performs pushing, pulling, or rotating operations, the force is transmitted to the cell harvesting member 152 so that the cell harvesting member 152 moves integrally with the tubular body 151 Or rotate.

The convex piece 158 of the cell harvesting member 152 and the groove 154 of the tubular body 151 are fitted to each other with the cell collecting member 152 mounted on the tip of the tubular body 151, do. Therefore, the cell-gathering member 152 does not rotate in the rotating direction 103 with respect to the tube body 151. [ The operating member 153 is inserted from the base end and the male screw portion 161 of the operating member 153 is screwed into the screw hole 159 of the cell harvesting member 152. [ Therefore, the cell-retrieving member 152 does not move in the longitudinal direction 101 with respect to the tube 151.

When the operating member 153 is inserted into the opening of the base end of the tubular body 151 from the side of the male screw portion 161 at the time of assembling the cell harvesting apparatus 150, the surface 164 of the flange portion 163, The flange portion 163 is elastically deformed so that the diameter of the large diameter portion 166 is expanded by coming into contact with the flange portion 167 and the flange portion 163 enters between the step portion 168 and the bulged portion 167. In this state, the flange portion 163 is engaged with the stepped portion 168 and the bulging portion 167 to be engaged with each other, and the relative movement of the flange portion 163 with respect to the tube body 151 is restricted with respect to the longitudinal direction 101. Further, in the engaging state, the operating member 153 is relatively rotatable in the rotating direction 103 with respect to the tube body 151.

After the cervical cells have been collected, as shown in Fig. 37, the proximal end side of the tubular body 151 and the handle portion 162 of the operating member 153 are held by the practitioner so that the handle portion 162 is held in the tubular body 151 . As a result, the male threaded portion 161 of the operating member 153 comes out of the screw hole 159 of the cell-gathering member 152. The tubular body 151 and the operating member 153 do not move relative to each other in the longitudinal direction 101 so that the male threaded portion 161 of the operating member 153 is pulled out from the threaded hole 159 of the cell collecting member 152 , The cell collecting member 152 is separated from the tip of the tube 151 and the convex piece 158 exits from the groove 154. The dimension along the center line 102 of the convex piece 158 and the dimension along the center line 102 of the male screw portion 161 are the same so that the distance between the male screw portion 161 and the male screw portion 161 158 and the groove 154 are engaged with each other and the male screw portion 161 is pulled out of the screw hole 159. The male screw portion 159 is pulled out of the groove 154 and easily escapes from the tube body 151 by gravity . The missing cell collection member 152 is accommodated in a storage container (not shown).

 According to the sixth embodiment, the same operational effects as those of the second embodiment can be obtained.

[Seventh Embodiment]

38, the cell harvesting apparatus 210 has a rod member 211 and a cell harvesting member 212. As shown in Fig. The cell-gathering member 212 is detachably attached to the distal end side of the rod 211. In the present embodiment, the direction in which the elongated bar material 211 extends is referred to as the longitudinal direction 101. An imaginary line passing through the center of the rod 211 along the longitudinal direction 101 is referred to as a center line 102. The direction of rotation about the center line 102 is referred to as the rotation direction 103. [ 38, and the side on which the cell harvesting member 212 is mounted is referred to as a distal end side (left side in FIG. 38).

[Rods (211)]

As shown in Figs. 38 and 39, the rod member 211 is an elongated member in the lengthwise direction 101. Fig. The rod 211 is formed, for example, in the shape of a cylinder as a molded product of synthetic resin. The material and shape of the bar material 211 are not particularly limited and may be, for example, a polygonal columnar shape. In addition, a plurality of elongated grooves may be formed in the longitudinal direction 101 to reduce the amount of resin, such as the rod 211. The external dimensions of the rod 211 and the length of the longitudinal direction 101 are set so as to be best suited for the operator to reach the proximal end side and to allow the cell harvesting member 212 to reach the cervical portion.

As shown in Figs. 39 and 41, an engaging portion 220 is provided at the distal end side of the rod material 211. Fig. The engaging portion 220 includes a convex portion 221 protruding in the longitudinal direction 101 from the tip end of the rod 211, hooks 222 and 223 protruding toward the outside of the rod 211, hooks 222 And 223, respectively, as shown in Fig. The claws 222 and 223 and the pressing portions 224 and 225 are disposed as a pair at positions symmetrical with respect to the center line 102. Since the claws 222 and 223 and the pressing portions 224 and 225 have the same shape except for the different arrangement, the claws 222 and 223 and the pressing portions 224 and 225 are provided with a pair of one- A detailed configuration is described by taking the portion 224 as an example.

The convex portion 221 is an outer shape of a substantially columnar shape protruding along the longitudinal direction 101 from the tip end of the rod member 211. The circumferential surface 226 of the convex portion 221 has a tapered shape that tapers toward the protruding end from the rod 211, that is, toward the tip. The center of the convex portion 221 coincides with the center line 102 of the bar material 211. That is, the convex portion 221 is disposed on the center line 102 of the rod 211. The tapered shape of the convex portion 221 has a shape in which the circumferential surface 226 of the convex portion 221 abuts against the circumferential surface 247 of the concave portion 246 when the concave portion 246 is inserted into the concave portion 246 described later.

The claws 222 and 223 protrude outward from the vicinity of the front end of the rod 211 and perpendicular to the center line 102. The claws 222 are in the shape of a mountain protruding toward the outside of the bar material 211 in the cross section along the center line 102. An inclined surface 227 inclined in a direction approaching the center line 102 toward the tip is formed at the tip end side of the hook 222. On the proximal end side of the claw 222, there is formed an engaging surface 228 which is substantially perpendicular to the center line 102. The inclined surface 227 and the engaging surface 228 are continuous and the boundary between the inclined surface 227 and the engaging surface 228 is a mountain-shaped ridge line. The distance from the centerline 102 of the mountain-shaped ridgeline of the claw 222 is approximately equal to the distance from the centerline 102 of the outer peripheral surface of the base end side of the rod 211.

A groove 229 extending along the center line 102 is formed between the claw 222 and the convex portion 221. A groove 230 is formed in the hook 223. The groove 229 opens to the outer surface of the rod 211. That is, the groove 229 passes through the rod 211. A space is formed between the claw 222 and the convex portion 221 by the groove 229. The ridgeline of the claw 222 approaches toward the center line 102 by elastically deforming the elastic deforming portion 231 located outside the groove 229 to tilt toward the convex portion 221 side. As shown in Fig. 41, the posture of the claw 222 to which the resiliently deformed portion 231 is not resiliently deformed is referred to as the engagement posture. 42, the posture of the claw 222, in which the elastically deformed portion 231 is inclined toward the convex portion 221 side, is referred to as a release posture. Likewise, due to the elastic deformation of the tongue-and-groove shaped portion 232 located on the outer side of the groove 230, the claw 223 changes posture from the engagement posture to the release posture.

The pressing portions 224 and 225 are provided on the outer sides of the elastic deforming portions 231 and 232, respectively. The pressurizing portion 224 is outwardly protruded from the outer surface of the elastic material portion 231 while being exposed to the outer surface of the rod material 211. 41, the pressing portion 224 has a mountain-like shape in a cross section along the center line 102 and is formed on an inclined surface 233 facing the base end side of the rod member 211, A plurality of grooves extending in the longitudinal direction 101 are formed at intervals. The pressing portion 224 is easily pushed in from the base end side of the rod material 211 by the inclined face 233 facing the proximal end side and the finger of the practitioner is easily slid toward the distal end side by the plurality of grooves formed in the inclined face 233 Do not. Further, a plurality of grooves are similarly formed on the inclined surface 234 of the pressing portion 225 as well.

[Cell harvesting member (212)]

As shown in Figs. 40 and 41, the cell harvesting member 212 has a main body 240 and a brush 241. Fig. The main body 240 is, for example, a molded product of synthetic resin. The brush 241 is inserted into a hole 242 formed at the tip end side of the main body 240 and fixed with an adhesive or the like. The brush 241 has a plurality of synthetic resin fibers fixed on a shaft made of stainless steel. The structure or shape of the brush 241 may be any known one such as a molded article of an elastomer. Therefore, as in the present embodiment, the axis extends along the center line 102 of the rod 211, the fibers may be radially extended from the axis, or other shapes may be employed.

A cylindrical portion 243 is formed on the base end side of the main body 240. The cylindrical portion 243 has an opening 244 on the base end side. The engaging portion 220 of the rod 211 can be inserted into the inner space of the cylindrical portion 243 through the opening 244 of the cylindrical portion 243. [ The opening 244 is elongated in the direction in which the claws 222 and 223 of the engaging portion 220 are disposed (vertical direction in Fig. 40). The inner space of the cylindrical portion 243 is set to a dimension and a shape in which the convex portion 221 and the hooks 222 and 223 of the engaging portion 220 can be inserted.

A concave portion 246 is formed in the end surface 245 opposite to the opening 244 in the inner space of the cylindrical portion 243. The concave portion 246 is provided on the centerline 102 of the cell harvesting member 212 and extends along the centerline 102 to the distal end side. The concave portion 246 is set to a shape and dimensions corresponding to the convex portion 221 of the engaging portion 220. That is, the concave portion 246 has a tapered shape in which its circumferential surface 247 is reduced in diameter toward the tip side so as to abut the circumferential surface 226 of the convex portion 221.

A pair of holes 249 and 250 are formed in the peripheral wall 248 of the cylindrical portion 243 so as to penetrate the peripheral wall 248 in a direction perpendicular to the center line 102. The holes 249 and 250 are disposed as a pair at positions symmetrical with respect to the center line 102. Since the holes 249 and 250 have the same shape except for the different arrangement, a detailed configuration will be described with respect to the holes 249 and 250 by taking a pair of one-side holes 249 as an example.

The hole 249 is a rectangular through hole. The shape of the hole 249 is set corresponding to the hook 222 of the engaging portion 220. The hooks 222 can be inserted into the holes 249. Therefore, the dimension of the hole 249 is set larger than the outer dimension of the hook 222. The engaging surface 228 of the hook 222 can be brought into contact with the peripheral edge of the hole 249 while the engaging claw 222 is inserted into the hole 249. [ As a result, the hooks 222 and the holes 249 are engaged with each other. Further, a hook 223 is inserted into the hole 250 and engaged.

[Cell harvesting device 210 in which the rod 211 and the cell harvesting member 212 are engaged]

The cell harvesting apparatus 210 is used in a state where the cell harvesting member 212 is mounted on the rod 211 in collecting the cervical cells. The convex portion 221 and the hooks 222 and 223 of the engaging portion 220 of the bar 211 are inserted into the inner space from the opening 244 of the cylindrical portion 243 of the cell harvesting member 212. The engaging portion 220 is inserted by arranging the hooks 222 and 223 in the elongated direction of the opening 244 with respect to the elongated opening 244. The cell collecting member 212 is substantially fixed with respect to the rotation direction 103 with respect to the bar member 211 by inserting the hooks 222 and 223 into the opening 244. [ The convex portion 221 is inserted into the concave portion 246 and the claws 222 and 223 are engaged with the holes 249 and 250 in the circumferential wall 248 of the cylindrical portion 243, The member 212 is fixed with respect to the rod member 211 in the longitudinal direction 101 and the rotational direction 103. [

The tapered circumferential surface 226 of the convex portion 221 of the engaging portion 220 is inserted into the concave portion 246 while the cell collecting member 212 is mounted on the rod 211 as shown in Fig. Is in press contact with the peripheral surface The pressing force of the circumferential surface 226 and the circumferential surface 247 causes the force of pushing the rod material 211 to the distal end side along the longitudinal direction 101 and the force of rotating the rod material 211 in the rotational direction 103 And is transferred to the cell harvesting member 212. The claws 222 and 223 of the engaging portion 220 inserted into the holes 249 and 250 of the peripheral wall 248 of the cylindrical portion 243 are engaged with the peripheries of the holes 249 and 250 It is preferable that it does not abut the edge. As a result, no load is applied to the hooks 222 and 223 in the transmission of these forces.

Even if the circumferential surface 226 slips with respect to the circumferential surface 247 when the rotating force in the rotation direction 103 is transmitted from the rod 211 to the cell harvesting member 212, 223 abut against the peripheral edges of the holes 249, 250 so that the rod 211 does not revolve with respect to the cell harvesting member 212.

The engagement of the claws 222 and 223 with the holes 249 and 250 of the peripheral wall 248, for example, the engagement surface 228 of the claw 222 is engaged with the peripheral edge of the hole 249 The force for pulling the bar material 211 along the longitudinal direction 101 toward the proximal end side is transmitted to the cell harvesting member 212.

 After the cervical cells are collected, as shown in FIG. 42, the pressurizing portions 224 and 225 are pressed to change the posture of the claws 222 and 223 in the engagement posture to the release posture. The inclined surfaces 233 and 234 of the pressing portions 224 and 225 are directed toward the base end side of the bar stock 211 so that they do not come into direct contact with the cell gathering member 212 but press the pressing portions 224 and 226 from the base end side of the bar stock 211, 225 can be pressurized. Since the pressing portions 224 and 225 are disposed at symmetrical positions with respect to the center line 102 and the pressing directions are opposite to each other, the pressing portions 224 and 225 are fitted so that both of them can be easily pressed at one time Do.

The elastic deformation portions 231 and 232 are elastically deformed so as to be close to the convex portion 221 by the pressing portions 224 and 225 being pressed. As a result, the claws 222 and 223 also move in the direction of approaching the convex portion 221, thereby becoming the releasing posture. The claws 222 and 223 in the unlocking posture are disengaged from the holes 249 and 250 in the peripheral wall 248 of the cylindrical portion 243. As a result, the cell-gathering member 212 and the rod 211 can be relatively moved in the longitudinal direction 101. The cell collecting member 212 does not rotate in the rotating direction 103 with respect to the bar stock 211 in the state where the hooks 222 and 223 are inserted into the opening 244. [ The cell collecting member 212 is removed from the rod 211 by operating the longitudinal direction 101 of the rod 211 along the vertical direction so that the cell collecting member 212 is below the rod 211. The missing cell harvesting member 212 is accommodated in a storage container (not shown).

[Operation and effect of the seventh embodiment]

According to the seventh embodiment, the convex portion 221 of the engaging portion 220 is inserted into the concave portion 246 of the cylindrical portion 243, and the claws 222 and 223 in the engaged position are inserted into the cylindrical portion When the cells of the uterine cervix are collected by engaging with the holes 249 and 250 of the peripheral wall 248 of the cell harvesting members 212 and 243, the cell harvesting members 212 do not come off from the bar stock 211, Is easily separated from the rod 211.

 Further, since the pair of hooks 222, 223, the pressing portions 224, 225, and the holes 249, 250 are provided, the pressing portions 224, 225 at the time of collecting the cervical cells produce any external force The other of the claws 222 and 223 is in engagement with the holes 249 and 250 even if one of the corresponding claws 222 and 223 is applied in the unlocking posture and exits the holes 249 and 250 The cell collecting member 212 does not come off from the rod 211.

Since the pair of the hooks 222 and 223, the pressing portions 224 and 225 and the pair of the holes 249 and 250 are provided at positions symmetrical with respect to the center line 102, the pressing portions 224 and 225 There is less chance of external force applied at one time.

Further, since the engaging portion 220 is provided on the rod 211, it is not necessary to contact the cell collecting member 212 when pressing the pressing portions 224 and 225.

Since the convex portion 221 is provided on the rod 211, it is easy to increase the distance between the convex portion 221 and the claws 222 and 223 in the rod 211. [ This makes it possible to increase the amount of movement of the hooks 222, 223 from the engaged position to the released position. As a result, the amount of engagement between the claws 222, 223 and the holes 249, 250 of the peripheral wall 248 of the cylindrical portion 243 can be increased.

The convex portion 221 has a tapered shape in which the circumferential surface 226 is tapered toward the distal end and the circumferential surface 226 is formed in a state in which the cell gathering member 212 is mounted on the rod 211 When the practitioner pushes the bar 211 and the rotating force is transmitted to the cell harvesting member 212, these forces are transmitted to the hooks 222 and 223 and the circumferential surface 247 of the concave portion 246, No load is applied to the engagement portions with the holes 249 and 250. [

[Modified example of the seventh embodiment]

The convex portion 221 is provided in the rod 211 and the concave portion 246 is provided in the cell collecting member 212 so that the convex portion 221 is inserted into the concave portion 246 A configuration may be employed in which the concave portion 246 is provided in the bar material 211 and the convex portion 221 is provided in the cell collecting member 212 as shown in Fig.

In the above-described seventh embodiment, a pair of the hooks 222 and 223, the pressing portions 224 and 225, and the holes 249 and 250 are shown. However, as shown in FIG. 44, Only one of them may be provided with only the hook 222, the pressing portion 224 and the hole 249, for example. According to this configuration, it is not necessary to provide a space for a pair of the pawls 222 and 223, the pressing portions 224 and 225, and the holes 249 and 250, so that the external dimension of the rod 211 can be reduced, 220 can be made compact. The convex portion 221 and the concave portion 246 may be disposed offset from the center line 102.

In the seventh embodiment described above, a coil spring 235 may be provided in the concave portion 246 of the cell harvesting member 212 as shown in Figs. 45 and 46. Fig. 45, in a state where the cell-gathering member 212 is mounted on the rod member 211, the convex portion 221 of the rod member 211 is inserted into the concave portion 246 while compressively deforming the coil spring 235 And the claws 222 and 223 are engaged with the holes 249 and 250 of the peripheral wall 248 of the cylindrical portion 243 so that the cell collecting member 212 is moved in the longitudinal direction 101 and the direction of rotation 103. As shown in Fig. Further, the cell-gathering member 212 is retained in the state of being mounted on the rod 211 against the elastic support force of the coil spring 235.

46, the pressing portions 224, 225 are pressed and elastically deformed such that the elastic deforming portions 231, 232 come close to the convex portion 221, so that the hooks 222, 223 move and become the releasing posture . Therefore, the cell-gathering member 212, which receives the elastic support force of the coil spring 235, escapes from the rod 211 along the longitudinal direction 101. Therefore, the cell harvesting member 212 is reliably and easily separated from the bar material 211.

In the seventh embodiment described above, there is shown a configuration in which the engaging portion 22 is provided on the rod 211, and the cylindrical portion 243 is provided on the cell harvesting member 212. However, The cell collecting member 212 may be provided with the engaging portion 220. [

In the seventh embodiment described above, the convex portion 221 has a tapered shape in which the circumferential surface 226 is tapered toward the distal end. In the state where the cell collection member 212 is mounted on the rod 211, The circumferential surface 226 of the convex portion 221 and the circumferential surface 247 of the concave portion 246 do not come into pressure contact with each other but the concave portion 246 is pressed against the circumferential surface 247 of the concave portion 246 May be adopted. In this configuration, the force in the rotation direction 103 is not transmitted by the pressing contact between the convex portion 221 and the concave portion 246. [ The force in the rotating direction 103 is transmitted from the rod member 211 to the cell harvesting member 212 by, for example, engaging the hooks 222 and 223 with the holes 249 and 250. [ When the convex portion 221 is polygonal and the concave portion 246 is a polygonal shape in which the polygonal shape of the convex portion 221 is fitted into the concave portion 246, The force in the direction 103 is transmitted from the rod 211 to the cell harvesting member 212.

In the seventh embodiment described above, the convex portion 221 of the engaging portion 220 of the rod member 211 is an outer shape of a substantially columnar shape protruding along the longitudinal direction 101 from the tip end of the rod member 211, As shown in Figs. 47 and 48, the convex portion 221 has a shape of "+ (positive)" in cross section perpendicular to the center line 102, which protrudes along the longitudinal direction 101 from the tip end of the rod 211 The outer shape of the column body may also be used.

The concave portion 246 formed in the end surface 245 opposite to the opening 244 in the inner space of the cylindrical portion 243 in conformity with the shape of the convex portion 221 is formed in the convex portion 221 of the " The outer surface of the " + " shape corresponds to the outer surface of the convex portion 221 of the " + " shape and the outer surface of the convex portion 221, Respectively.

The convex portion 221 and the concave portion 246 having the "+" shape corresponding to each other can easily transmit the force in the direction of rotation 103 from the rod 211 to the cell harvesting member 212. The convex portion 221 is not easily bent against the external force from the direction orthogonal to the center line 102 and the convex portion 221 is bent so that the claws 222 and 223 come out of the holes 249 and 250 Is not easily generated.

As shown in Fig. 49 (A), the convex portion 221 of the " + " shape has the convex portion 221 in the center line 102 (the direction perpendicular to the plane of Fig. (The dimension d1 along the left-right direction in FIG. 49 (A) and the dimension d2 along the vertical direction) may be different from each other. As a result, when the convex portion 221 is rotated 90 degrees about the center line 102, the cross-sectional shape of " - "

When the shape of the convex portion 221 described above is adopted, as shown in Fig. 49 (B), concave portions 221 formed on the end face 245 of the cylindrical portion 243 in conformity with the shape of the convex portion 221 described above The "+" -shaped groove of the portion 246 also has two "- (minus)" shapes (the dimension d1 along the left and right direction in FIG. 49 (B) perpendicular to the center line 102, (D2)).

The convex portion 221 and the concave portion 246 described above are formed in such a manner that the claws 222 and 223 of the rod member 211 and the holes 249 and 250 of the circumferential wall 248 of the cylindrical portion 243 are engaged with each other . (The dimension d1) which is the thicker side of the "+" shape of the convex portion 221 and the "-" shape (the dimension d1) which is the thicker side of the "+" shape of the concave portion 246, The hooks 222 and 223 can be engaged with the holes 249 and 250. [

Conversely, the relative positional relationship between the rod 211 and the cylindrical portion 243 of the cell-gathering member 212 is rotated by 90 degrees with respect to the centerline 102 so that the hooks 222 and 223 engage with the holes 249 and 250 Shape (dimension d1), which is the thicker side of the convex portion 221, is larger than the " - " shape (the dimension d1) of the concave portion 246 the convex portion 221 in the shape of the "-" shape is thicker than the concave portion 246, so that the cell gathering member 212 is placed on the rod 211 at this positional relationship, Can not be mounted. The convex portion 221 is formed in the concave portion 246 in a state in which the claws 222 and 223 are not engaged with the holes 249 and 250 at the time of assembling the rod 211 and the cell harvesting member 212 It is prevented from being inserted.

Each of the cell collecting apparatuses 10, 50, 70, 80, 110, 150 and 210 may have a cap 300 covering the cell collecting members 12, 52, 82, 112, 152, do. As shown in Fig. 50, the cap 300 is a cylindrical shape capable of containing the cell-gathering member 212, The ends 301 and 302 are open. Therefore, the inner diameter of the cap 300 is equal to or slightly larger than the maximum outer diameter of the cell harvesting member 212. The end 301 of the cap 300 may be clogged and the inner diameter of the cap 300 may be constant along the longitudinal direction 101 You do not have to do.

50, the state in which the cell harvesting member 212 is mounted on the bar stock 211, that is, the hooks 222, 223 of the bar stock 211 are inserted into the holes 249, 250 of the cell harvesting member 212 The cap 300 is inserted into the cell harvesting apparatus 210 by inserting the cell harvesting member 212 into the end 302 of the cap 300 while being fitted. The end 302 of the cap 300 abuts against the end faces 251 and 252 on the tip end side of the pressing portions 224 and 225 (the side facing the end 302 of the cap 300). The end faces 251 and 252 are planes substantially orthogonal to the center line 102 of the rod 211 and protrude outward from the outer peripheral surface of the end 300 of the cap 300 mounted on the cell harvester 210 . The dimension at which the end faces 251 and 252 protrude from the outer circumferential surface of the cap 300 is greater than the dimension at which the pushing portions 224 and 225 can press toward the center line 102. [ The end faces 251 and 252 protrude outward beyond the outer circumferential face on the end 302 side of the cap 300 even when the pressing portions 224 and 225 are pressed toward the center line 102. [

Since the end 302 of the cap 300 is not inserted to the base end side (right side in FIG. 50) of the rod member 211 than the end faces 251 and 252, the cap 300 is mounted on the cell- The pressing portions 224 and 225 are pushed into the inner space of the cap 300 and are not pressed toward the center line 102. [ That is, when the cap 300 is mounted on the cell harvesting apparatus 210, the hooks 222 and 223 are not removed from the holes 249 and 250. Thereby, when the cap 300 is separated from the cell harvesting apparatus 210, the cell harvesting member 212 together with the cap 300 does not unintentionally escape from the bar stock 211.

As shown in Fig. 51, the end faces 251 and 252 of the pressing portions 224 and 225 are formed so that the outer side relative to the center line 102 is closer to the tip end side of the rod material 211 The end 302 of the cap 300 rides over the end faces 251 and 252 and is more reliably prevented from advancing toward the proximal end side of the bar stock 211. As a result,

As shown in Fig. 52, even when the end faces 251 and 252 of the pressing portions 224 and 225 are not brought into contact with the end face 302 of the cap 300, The rod 211 is shifted in phase by 90 degrees with respect to the center line 102 from the distal end side of the rod 211, that is, the pushing portions 224 and 225, and the rods 211 are provided on the distal end side of the rod 211 rather than the end faces 251 and 252, The protrusions 253 and 254 protruding outward from the outer circumferential surface of the protrusion 252 may be provided. The convex portions 253 and 254 protrude from the outer surface of the end portion 302 side of the cap 300 to the outside of the rod member 211. The end face 302 of the cap 300 mounted on the cell sampling device 210 is in contact with the convex portions 253 and 254 so that the end faces 251 and 252 of the pressing portions 224 and 225 And therefore the same operational effect as that described above can be obtained. Further, only one of the convex portions 253 and 254 may be provided on the rod member 211. [

53, the end surfaces 251 and 252 of the pressing portions 224 and 225 may be bent in a direction away from the end surface 302 of the cap 300, An annular flange 255 projecting outwardly from the outer peripheral surface of the rod member 211 may be provided at the tip end side of the rod member 211. [ The flange 255 protrudes outwardly of the bar stock 211 from the outer peripheral surface of the end of the cap 300 on the side of the end 302. The end face 302 of the cap 300 attached to the cell sampling device 210 is in contact with the face on the side of the tip end of the flange 255 and is pressed against the end face 251 of the pressing portion 224, Since it does not advance to the base end side of the base plate 211, the same operational effect as that described above can be obtained. The flange 255 may be provided only on a part of the periphery of the center line 102 without being necessarily provided continuously around the center line 102 of the rod material 211.

54, even if the end faces 251 and 252 of the pressing portions 224 and 225 do not come in contact with the end face 302 of the cap 300, Diameter portion 256 having an outer diameter larger than the outer diameter of the end portion 302 of the cap 300 may be provided on the tip end side of the cap 300. [ The end face 302 of the cap 300 attached to the cell harvesting apparatus 210 is in contact with the end face of the large diameter portion 256 and extends from the end faces 251 and 252 of the pressing portions 224 and 225 And does not advance to the base end side of the bar material 211, so that the same operational effect as that described above can be obtained. The large diameter portion 256 may not necessarily be provided continuously around the center line 102 of the rod member 211 but may be provided as a convex portion only in a part around the center line 102.

10, 50, 70, 80, 110, 150: Cell harvesting device
11, 51, 81, 111, 151:
12, 52, 82, 112, 152: cell harvesting member
13, 53, 83, 113, 153: operating member
31:
42, 43, 92, 93: Elastic piece (deformation part)
54, 154: groove (fitting portion)
58, 158: convex portion (fitting portion)
59, 159: Screw hole (threaded portion)
61, 161: Male threaded portion (locking portion, threaded portion)
72: engaging portion (locking portion)
96: locking portion 114: locking member
210: cell harvesting apparatus 211: sewing machine
212: cell harvesting member 220:
221: convex portion 222, 223: hook
224, 225: pressing portion 243: cylindrical portion
246: recess 248: circumferential wall
249, 250: hole

Claims (14)

A tubular body having a first end and a second end,
A cell harvesting member attachable to a first end of the tubular body,
A locking part for holding the cell harvesting member in a state of being mounted on a first end of the tubular body,
A lock position in which the cell harvesting member is held on the first end of the tubular body or a lock posture in which the cell harvesting member is held in a disengaged posture in which the cell harvesting member is not mounted on the first end of the tubular body A cell harvesting apparatus having an operating member,
Wherein the operating member is moved in the posture by operating the second end side while the operating member is inserted into the tubular body. The method according to claim 1,
And the locking portion is provided on the operating member. 3. The method of claim 2,
Wherein the cell harvesting member has an elastically deformable deformation portion,
Wherein the locking portion presses the deformed portion to the tubular body in the locking posture. The method of claim 3,
And the deforming portion is engaged with the tubular body by being pressed against the lock portion. 5. The method according to any one of claims 2 to 4,
Wherein the operating member is held in a state in which the locking portion is in a locking posture by being screwed to the tubular body at a second end side of the tubular body. 5. The method according to any one of claims 2 to 4,
Wherein the operating member is held in a state in which the locking portion is in a locking posture by being engaged with the tubular body at a second end side of the tubular body. 3. The method of claim 2,
Wherein the locking portion includes a fitting portion for fitting the cell harvesting member and the tube body around a virtual line passing through the first end and the second end so as not to be rotatable with each other and a screw coupling portion for screwing the operating member and the cell harvesting member Lt; / RTI > 3. The method of claim 2,
Wherein the locking portion includes a fitting portion for fitting the cell harvesting member and the tubular body non-rotatably around virtual lines passing through the first and second ends, and an engaging portion for engaging the operating member and the cell harvesting member Lt; / RTI > 9. The method of claim 8,
Wherein the engaging portion engages with the cell harvesting member in a locking posture at a first rotational position of the operating member about an imaginary line passing through the first and second ends, And is not engaged with the harvesting member. A cell harvesting apparatus in which an engaging portion is provided on one side of a bar or cell harvesting member and the cell harvesting member is detachable at the tip of the bar harvesting material,
The engaging portion
A convex portion or a concave portion extending along the longitudinal direction of the rod or the cell harvesting member,
A hook protruding toward the outside of the rod or the cell harvesting member and elastically changing its posture from the engagement posture to the release posture,
And a pressing portion which is exposed to the outer surface of the rod or the cell harvesting member and is urged to change the posture from the engagement posture to the release posture,
On the other side of the rod or the cell harvesting member,
A cylindrical portion into which the convex portion or the concave portion and the hook are insertable into the inner space,
A concave portion or a convex portion into which the convex portion or the concave portion can be inserted,
And a hole is provided in the peripheral wall of the cylindrical portion, and a hole is formed in the engaging posture in which the hook is inserted and engageable. 11. The method of claim 10,
The pair of hooks, the pressing portion and the hole are provided at positions symmetrical with respect to the center line along the longitudinal direction of the rod or the cell harvesting member,
And the convex portion and the concave portion are disposed on the center line. The method according to claim 10 or 11,
And the engaging portion is provided in the bar material. 13. The method of claim 12,
And the convex portion is provided in the bar material. 14. The method according to any one of claims 10 to 13,
Wherein the convex portion has a tapered shape tapering toward the tip and the tapered surface of the convex portion is in contact with the concave portion in a state where the cell collection member is attached to the distal end of the bar material.

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