KR20150095346A - Apparatus for measuring health indexes in retinal vessels using an optical sensor and method for processing light reflected from vessels for calculation of health indexes - Google Patents

Apparatus for measuring health indexes in retinal vessels using an optical sensor and method for processing light reflected from vessels for calculation of health indexes Download PDF

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KR20150095346A
KR20150095346A KR1020140016535A KR20140016535A KR20150095346A KR 20150095346 A KR20150095346 A KR 20150095346A KR 1020140016535 A KR1020140016535 A KR 1020140016535A KR 20140016535 A KR20140016535 A KR 20140016535A KR 20150095346 A KR20150095346 A KR 20150095346A
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South Korea
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light
retina
blood vessel
light source
vessel inside
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KR1020140016535A
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Korean (ko)
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KR101571135B1 (en
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서민아
김재헌
이석
김철기
정진욱
박기호
이택진
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한국과학기술연구원
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Abstract

A portable apparatus for measuring a health index includes a light source which emits infrared rays to a retinal vessel of an object, a photodiode which receives light reflected on the retinal vessel, and a processor which calculates a value related to the health index of the retinal vessel by measuring the intensity of the light inputted to the photodiode. Thereby, the health index is conveniently, safely, and precisely measured in the retinal vessel by using the transparency of an eye to the retina with regard to the light.

Description

TECHNICAL FIELD The present invention relates to an apparatus for measuring intra-vascular health index using a photo sensor and a method for processing a vascular light reflected from a subject,

Embodiments relate to the field of optics and medical devices. Particularly, in the embodiments, the concentration of representative health indicators including blood glucose, cholesterol, oxygen, and carbon dioxide is estimated by irradiating light in a blood vessel inside the retina with light of a specific wavelength, and the result is transmitted to a communication device wirelessly .

Periodic observation of blood vessel and cholesterol ratio and rate of change in blood vessels is very important for early detection of lifestyle-related diseases (for example, diabetes mellitus) that are difficult to cure and are at high risk for various complications. One of the major health indicators is the rate of change in blood glucose concentration. To measure this, we use a method of analyzing the blood components extracted from the blood. However, in the case of blood collection, it is an invasive method that damages the body, giving pain and suffering to the patient, and there is also concern about infection.

Therefore, methods of measuring blood glucose without blood sampling are being designed. For example, a biosensor device capable of measuring blood glucose in the body by attaching a sensor to the body that senses radio waves coming back by irradiating a weak microwave to blood vessels in the skin, and a tissue patch adhered to the skin for a predetermined period of time And a method of measuring blood glucose through this body fluid have been proposed. In addition, a real-time blood glucose measurement technique using an internal nano-porous sensor has been developed by domestic research team. However, this blood sugar measuring device has a limitation in that it has an operating life of about 30 days and has to undergo a surgical method of inserting into the human body. In addition, there is no current measurement method that allows individuals to periodically observe health indicators (eg, cholesterol, oxygen, and carbon dioxide) other than blood sugar.

A method designed to break out of this surgical method is optical biosensor technology that analyzes the components of health indicators in blood vessels using light. Representative techniques include spectroscopy using far infrared rays and Raman spectroscopy techniques that are transparent to most organs of the human body. Raman spectroscopy is a method of estimating the concentration of glucose by measuring the degree of scattering due to the rotation of excited glucose molecules in the excitation laser light and the method of measuring the health indicators such as blood glucose in the blood using infrared spectroscopy And measuring the concentration of glucose using the degree of scattering. Infrared wavelengths are transparent to the organs of the human body and are therefore known to be very safe when low power is used because they do not cause secondary reactions. All of these techniques are based on measuring the blood glucose level in the blood vessels by measuring the radio waves reflected from thin skin and the transmitted radio waves by irradiating the radio waves to the skin tissue of the human body.

However, these methods have disadvantages in that most of the irradiated light does not reach the blood vessel because the blood vessel to be measured is located under the skin tissue, and the accuracy of measurement is low due to errors in measuring light reflected from other tissues of the skin.

Omar S. Khalil, DIABETES TECHNOLOGY & THERAPEUTICS Vol. 6, No. 5 (2004)

One aspect of the present invention is to eliminate the inconvenience such as pain and mental burden caused by blood collection when blood glucose is measured periodically by patients and fear of infection through a blood collection site, And to manage the results effectively.

According to an embodiment of the present invention, a portable health index measurement device includes: a light source for irradiating infrared rays to blood vessels inside a retina of a subject; A photodiode for receiving light reflected from a blood vessel inside the retina; And a processor for calculating a value related to the health index of the blood vessel inside the retina by measuring the intensity of the light incident on the photodiode.

According to an embodiment of the present invention, there is provided a blood vessel reflection light processing method comprising the steps of: irradiating a blood vessel inside a retina of a subject with a light source to infrared rays; Introducing light reflected from a blood vessel inside the retina into a photodiode; Measuring the intensity of light incident on the photodiode; And calculating a value associated with the health index of the blood vessel inside the retina through the intensity of the measured light.

According to one aspect of the present invention, by measuring the health index in the blood vessel inside the retina, the health index can be measured more accurately in a short time.

Also, according to an aspect of the present invention, the measured health index data can be transmitted to a communication device and managed effectively.

1 is a schematic perspective view of a portable health indicator measurement device according to an embodiment of the present invention.
2 is a cross-sectional view illustrating an internal structure of a portable health indicator measurement device according to an embodiment of the present invention.
3 is a flowchart of a method for processing reflected light of a blood vessel according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

1 is a schematic perspective view of a portable health indicator measurement device according to an embodiment of the present invention.

In one embodiment, the portable health indicator measurement device 100 may include a body 110 with one or more of the other components of the device mounted thereon. The main body 110 is small and lightly housed so that the user can use it with one hand. The portable health indicator 100 may include an eye contact unit 110 attached to the body 110 to measure the health indicators in the blood vessels inside the retina so as to irradiate light directly to the eyeball of the object, (120). At this time, the object may be human or animal. In one embodiment, the body 110 of the portable health indicator measurement device 100 may include a display 130 for displaying measured health indicator data.

2 is a cross-sectional view illustrating an internal structure of a portable health indicator measurement device according to an embodiment of the present invention.

The portable health indicator measurement device may include a light source 210 and a photodiode 270. The infrared rays irradiated from the light source 210 enter the eye 240 of the subject and reach the blood vessel inside the retina. At this time, since there is a liquid capable of absorbing light in the eye, among the health indexes including blood glucose, cholesterol, oxygen and carbon dioxide, the absorption to the health index to be measured is high and the absorption to water is low A light source can be used. For example, when a blood glucose is to be measured, absorption of blood sugar is high and absorption of water is low. Or, generally, absorption for health indicators is high, and absorption for water may use light in the lower wavelength band.

Light 250 reflected from the retinal vessels is incident on a health indicator and is sent to a photodiode 270. The photodiode 270 measures the intensity of the incident light and analyzes the intensity of light measured through the processor 280. The processor computes a health index value in the blood vessel by estimating absorption of light by blood glucose, cholesterol, oxygen, and carbon dioxide. Each element that can be a health indicator, such as blood sugar, cholesterol, etc., has its own absorption wavelength, so the amount of each health indicator can be determined through the intensity of infrared rays having a specific wavelength. For example, if the reflectance of a specific wavelength of infrared light in a retinal blood vessel of a normal person with a blood glucose concentration of 100 mg / dl on fasting is 1, the reflectance is 1.1 in a diabetic patient with a blood glucose concentration of 200 mg / dl, The relative reflectance or absorptivity according to the change in the blood glucose concentration is compared with the reference value such that the reflectance is set to 1.15 for a person with 250 mg / dl. At this time, since the reflectance or absorptivity of infrared rays is linearly proportional to the change in concentration of blood sugar in the blood, the blood glucose concentration of the subject can be calculated by measuring the reflectance. Measurements of blood glucose as well as other health indicators are made in a similar way. Accordingly, a user who wishes to measure a health indicator of an object through the portable health indicator measuring apparatus according to an embodiment can check the health state of the object through the calculated health indicator value, and can track the change of the health state.

Since the eye is transparent to the retina with respect to light, it is easy to observe the blood vessels inside the retina using light. Therefore, the measurement of the health index using the blood vessels in the retina can reduce the errors due to the surrounding environment as compared with the measurement through other parts such as the skin, thereby making it possible to measure the accurate concentration of each index. In other words, since blood glucose can be measured very easily and precisely compared to a technique of measuring blood glucose in the blood vessel through the skin in the past, it has an advantageous effect over the prior art.

In addition, it is possible to measure not only blood glucose but also health indicators (for example, cholesterol, oxygen, carbon dioxide, etc.) measurable through blood while changing the wavelength of light to be irradiated to the eyeball.

The light source 210 may be any light source that emits infrared rays such as an LED, a laser, or the like. According to an embodiment of the present invention, the infrared rays irradiated by the light source 210 may have high absorption for health indicators and low absorption for water. For example, the wavelength of the infrared ray irradiated by the light source 210 may be a wavelength of 1 μm or more and 3 μm or less. Further, the wavelength of the infrared ray may be 900 nm or more and 1700 nm or less.

In addition, according to an embodiment of the present invention, the light source 210 may be a broadband infrared light source, and in this case, a plurality of health indicators can be measured simultaneously. Blood glucose, and cholesterol have unique absorption wavelengths. These wavelengths do not overlap each other. Therefore, when an infrared light source having a wide wavelength range is used, the reflected light from the retinal blood vessels is received, A plurality of health indicators can be obtained at the same time by measuring the intensities.

According to the embodiment of the present invention, since the light irradiated from the light source does not have to pass through a thick skin layer as in the prior art, the portable health index measuring device can be applied to a conventional apparatus for measuring blood glucose concentration in a blood vessel And a light source 210 having a lower output than the light source 210.

According to one embodiment of the present invention, the portable health indicator measurement apparatus may further include a wireless communication module 290. [ The wireless communication module 290 transmits the health index data calculated by the processor in the photodiode 270 to an external communication device such as a smart phone or a computer. Accordingly, when a user using the portable health indicator measures the light in the eyeball with the eye contact portion touching the eye of the subject, the concentration of the health indicator in the blood in the blood vessel is measured in real time and transmitted to the external communication device The result can be confirmed at a desired communication device (e.g., a computer of a primary care doctor).

In accordance with one embodiment of the present invention, the portable health indicator measurement apparatus may further include one or more mirrors 260. The mirror 260 reflects from a blood vessel inside the retina and changes the direction of the light coming into the health index measuring device so that it can be incident on the photodiode 270. The health index measuring device includes a mirror 260 to convert the light traveling direction in the health index measuring device to the longitudinal direction of the main body 110 (FIG. 1), and then to allow the light to enter the photodiode 270 have. In other words, since the main body 110 (FIG. 1) can be extended in the longitudinal direction, a user who wants to check his or her health condition through the health indicator measures the body 110 It becomes possible to use a health indicator measuring device in a posture.

According to one embodiment of the present invention, the portable health indicator measurement apparatus may further include a condenser lens 220. The condensing lens 220 condenses the light emitted from the light source 210 so as to be incident on the retina 230 of the target object accurately and the light 250 reflected from the blood vessel inside the retina is reflected by the inside of the health indicator .

As described above, the portable health index measuring device measures the intensity of reflected light and measures the concentration of the health indicators in the blood vessels inside the retina after irradiating the eye with the infrared rays which are safe to the human body. In addition, the result is transmitted to an external communication device through a wireless communication module, so that a medical staff such as a primary care physician can check the health state of the object in real time, thereby making it a quick and convenient medical device.

3 is a flowchart of a blood vessel reflection light processing method according to an embodiment. The blood vessel reflection light processing method can be performed for calculating the health index using the portable health indicator measurement device described above.

Specifically, first, a blood vessel inside the retina of the subject can be irradiated with infrared rays by a light source. Next, light reflected from the blood vessel inside the retina can be incident on the photodiode. Then, the intensity of the light incident on the photodiode can be measured. The intensity of the measured light can then be used to calculate values associated with the health indicators of the blood vessels inside the retina.

According to one embodiment, the value associated with the computed health indicator may be wirelessly transmitted to the communication device.

According to one embodiment, when the light reflected from the blood vessel inside the retina is incident on the photodiode, the direction of the reflected light is switched through a mirror, or the light reflected from the blood vessel inside the retina is condensed through the condenser lens .

In addition, according to one embodiment, when infrared rays are irradiated to blood vessels inside the retina, light other than infrared rays emitted from the light source can be blocked.

According to one embodiment, when infrared rays are irradiated to blood vessels inside the retina, the wavelength of the infrared rays may be 1 탆 or more and 3 탆 or less or 900 nm or more and 1700 nm or less. According to one embodiment, the light source may be a broadband infrared And the step of computing a value associated with the health indicator may comprise simultaneously computing values associated with the plurality of health indicators.

210: light source 220: condenser lens
240: eyeball 260: mirror
270: photodiode 280: processor
290: Communication module

Claims (16)

A portable health indicator measurement device,
A light source for irradiating infrared rays to blood vessels inside the retina of the subject;
A photodiode for receiving light reflected from a blood vessel inside the retina; And
A processor for measuring intensity of light incident on the photodiode and calculating a value related to a health index of a blood vessel inside the retina;
And a portable health indicator measuring device. The method according to claim 1,
And a wireless communication module for transmitting the value calculated by the processor to an external communication device. The method according to claim 1,
Further comprising a mirror for converting a direction of light reflected from a blood vessel inside the retina and making the light enter the photodiode. The method according to claim 1,
And a condensing lens for condensing the light by the light source into a blood vessel inside the retina. The method according to claim 1,
The portable health indicator measurement device comprises:
A main body on which the light source, the photodiode, and the processor are mounted; And
And an eye contact portion attached to the body to contact the object so as to surround the eyeball of the object. The method according to claim 1,
Wherein the light source emits infrared rays having a wavelength of 1 占 퐉 or more and 3 占 퐉 or less. The method according to claim 1,
Wherein the light source irradiates infrared rays having a wavelength of 900 nm or more and 1700 nm or less. The method according to claim 1,
Wherein the light source is a broadband infrared light source and the processor simultaneously calculates values associated with a plurality of health indicators. Irradiating a blood vessel inside the retina of the subject with infrared light by a light source;
Introducing light reflected from a blood vessel inside the retina into a photodiode;
Measuring the intensity of light incident on the photodiode; And
Calculating a value associated with a health index of the blood vessel inside the retina through the intensity of the measured light;
The method comprising the steps of: 10. The method of claim 9,
And wirelessly transmitting a value associated with the calculated health index to a communication device. 10. The method of claim 9,
Wherein the step of entering the photodiode comprises the step of switching the direction of the light reflected by the blood vessel inside the retina through the mirror. 10. The method of claim 9,
Wherein the step of entering the photodiode comprises the step of condensing light reflected from a blood vessel inside the retina through a condenser lens. 10. The method of claim 9,
Wherein the step of irradiating the blood vessel inside the retina with infrared light comprises blocking light other than infrared rays emitted from the light source. 10. The method of claim 9,
Wherein the step of irradiating the blood vessel inside the retina with infrared light comprises irradiating the infrared ray having a wavelength of not less than 1 占 퐉 and not more than 3 占 퐉. 10. The method of claim 9,
Wherein the step of irradiating the blood vessel inside the retina with infrared light comprises irradiating infrared rays having a wavelength of 900 nm or more and 1700 nm or less. 10. The method of claim 9,
Wherein the light source is a broadband infrared light source and wherein calculating the value associated with the health index of the blood vessel inside the retina through the intensity of the measured light comprises simultaneously calculating values associated with the plurality of health indexes, A method for treating blood vessel reflection light for calculation.
KR1020140016535A 2014-02-13 2014-02-13 Apparatus for measuring health indexes in retinal vessels using an optical sensor and method for processing light reflected from vessels for calculation of health indexes KR101571135B1 (en)

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US11291374B2 (en) 2019-04-10 2022-04-05 Samsung Electronics Co., Ltd. Apparatus and method for estimating bio-information
US11730421B2 (en) 2019-03-29 2023-08-22 Welch Allyn, Inc. Sepsis detection and monitoring

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JP4872082B2 (en) 2006-06-07 2012-02-08 国立大学法人九州工業大学 Personal authentication method and personal authentication device using fundus blood flow measurement by laser light
JP5170625B2 (en) 2006-10-04 2013-03-27 幸功 瀧畑 Infrared fundus photographing method and apparatus

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Publication number Priority date Publication date Assignee Title
US11730421B2 (en) 2019-03-29 2023-08-22 Welch Allyn, Inc. Sepsis detection and monitoring
US11291374B2 (en) 2019-04-10 2022-04-05 Samsung Electronics Co., Ltd. Apparatus and method for estimating bio-information

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