KR20150083231A - Drug Injection Pump using Osmotic Pressure - Google Patents

Abstract

The present invention relates to a drug injection pump using osmotic pressure, comprising: a housing; a drug storage unit disposed inside the housing to store a drug within a contractible container, and formed with a drug discharge hole, for discharging the stored drug to the outside by pressure, on one side thereof; and a driving unit disposed on one side of the drug storage unit and pressing the drug storage unit in the case that the container is expanded due to the osmotic pressure. The driving unit includes: at least two containers storing solutions with different concentrations; a tube connecting the two or more containers and moving the solutions stored in the containers; a membrane positioned within the tube and making solvents and solutes within the solutions permeate through selectively; and an opening and closing adjustment unit adjusting an opening degree of the tube to control a solution amount moving through the tube. The present invention may inject the dangerous drug into a patient precisely and continuously with regular injection pressure, thereby being capable of minimizing side effects which may occur to the patient.

Description

[0001] The present invention relates to an osmotic pressure pump,

The present invention relates to a drug infusion pump using osmotic pressure.

Generally, a drug infusion pump is a therapeutic device for continuously and safely supplying a very small amount of drug to highly sensitive and highly potentially adverse drugs.

Conventionally, when a drug to be injected to a patient is prescribed, the drug is fixed at a position higher than the injection position of the patient, and the opening and closing parts are manipulated to determine the injection rate and injection amount of the drug according to experience.

However, such a drug injector has a problem that the pressure and the injection rate vary depending on the amount of the drug contained in the container. Therefore, in the case of a drug requiring a precise dosage due to an anesthetic agent and an analgesic agent, a general drug injector can not be used.

Therefore, in order to solve the above problems, Korean Patent Registration No. 1106286 has proposed a drug infusion pump.

However, there is a problem in that the electric and mechanical drug injection pump requires a lot of energy and power to increase the drug injection pressure. If the injection pressure is low, the body fluid in the patient's body may flow back to the drug injector.

Accordingly, the present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a technique capable of stable injection of a drug by generating a high injection pressure using low power or energy.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are not to be construed as limiting the present invention. Aspects of the present invention will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings, in which: FIG. It will be possible.

According to an aspect of the present invention, there is provided a drug delivery device comprising: a housing; a drug reservoir disposed inside the housing and capable of contracting, the drug discharge port through which a drug stored by pressure is discharged, And a driving unit positioned at one side of the drug storage unit and pressing the drug storage unit when the container is inflated by osmotic pressure, wherein the driving unit includes at least two containers in which solutions having different concentrations are stored, A tube through which the solution stored in the container is transferred, a semi-permeable membrane positioned inside the tube and selectively permeating the solvent and the solute in the solution, Closing means for adjusting the amount of the solution.

The osmotic pressure generating vessel is connected to one side of the osmotic pressure generating vessel by a first tube, and the concentration of the solvent in the osmotic pressure generating vessel is lower than the concentration of the solvent stored in the osmotic pressure generating vessel. A second tube formed on the other side of the pressure regulating container and connected to the pressure regulating container for storing a low solvent, and a solvent same as the solvent stored in the pressure regulating container is stored, And a storage container.

Wherein the semipermeable membrane comprises a first semipermeable membrane formed on the first tube positioned between the osmotic pressure generating vessel and the pressure regulating vessel and having a porous membrane selectively permeating the solvent and the solute in the solution, And a second semipermeable membrane formed to selectively permeate the solvent and the solute in the solution, wherein the osmotic pressure is generated by the difference in the concentration of the solvent stored in the pressure regulating container and the osmotic pressure generating container, and when the osmotic pressure generating container expands , The osmotic pressure generating vessel receives the pressure of the drug storage part and the drug stored in the drug storage part is discharged to the drug discharge opening.

The opening / closing control means is a solenoid valve which is located in the second tube and opens or blocks the second tube.

Wherein the osmotic drug infusion pump measures at least any one of state information of the internal pressure of the pressure control container and the osmotic pressure generating container, the amount of the solvent injected into the osmotic pressure generating container, and the infusion pressure of the medicine discharged to the drug discharge port And a control unit for receiving the measured information from the measuring unit and the measurement unit, wherein the control unit controls the opening of the opening / closing control unit so that the injection pressure of the drug discharged to the drug discharge port is kept constant.

In addition, the osmotic drug infusion pump further includes an operation unit for operating the controller to adjust the infusion rate of the drug discharged to the drug discharge port.

The drug discharging port may further include bubble rejecting means for removing bubbles generated when the drug is discharged from the drug reservoir to the drug discharging port.

Therefore, according to the present invention, a dangerous drug can be injected into a patient with a precise and constant injection pressure, so that side effects that may occur to a patient can be minimized.

The monitoring of the injection pressure of the drug at all times allows the injection pressure to be automatically adjusted to the safe injection pressure automatically when the injection pressure of the drug suddenly changes, thereby minimizing the risk.

In addition, it is possible to inject a high drug injection pressure without external power or energy, has a simple mechanical structure, is light, easy to manufacture, and has high reliability of a drug injection pump.

1 is a simplified schematic diagram of an osmotic drug infusion pump in accordance with an embodiment of the present invention.

The preferred embodiments of the present invention will be described in more detail with reference to the accompanying drawings, in which the technical parts already known will be omitted or compressed for the sake of brevity.

≪ Description of the Configuration of the Present Invention &

1, the osmotic drug infusion pump 100 according to the present invention includes a housing 110, a drug storage unit 120, a driving unit 130, a measurement unit 140, a control unit 150, an operation unit 160 ).

The drug storage unit 120, the driving unit 130, the measurement unit 140, the control unit 150, and the operation unit 160 are disposed in the housing 110. The drug storage unit 120 are formed.

A wall is formed between the osmotic pressure generating vessel 131a and the pressure regulating vessel 131b so that the osmotic pressure generating vessel 131a can be expanded toward the drug storage unit 120. [

The drug reservoir 120 is located inside the housing 110. The drug reservoir 120 stores a drug to be injected into the patient. When external pressure is applied to the drug reservoir 120, 100 are made of a thin and soft material so that they can be easily deformed.

A drug discharge port 121 through which a drug is discharged is formed at one end of the drug storage part 120 and the drug stored in the drug storage part 120 is discharged to the outside when the drug discharge part 120 is pressed from the outside.

The drug discharge port 121 includes a foaming agent 121a for reducing a risk factor such as the damage of the blood vessel of the patient due to the bubbles inside the drug when the drug is injected into the patient.

A bubble eliminating portion 121a is located on one side of the drug discharge port 121 to form a semipermeable membrane for a gas which can not permeate the drug but can only permeate the gas, and a bubble discharge port through which the permeated gas can be discharged to the outside is formed.

The drug removed by the purge rejection 121a is injected into the patient through the drug discharge port 121. [

The driving part 130 is a component for pressing the drug storage part 120 on one side of the drug storage part 120 and includes a container 131, a tube 132, a semi- .

The container 131 includes an osmotic pressure generating vessel 131a, a pressure regulating vessel 131b, and a solvent storage vessel 131c.

The osmotic pressure generating vessel 131a is a container for storing a high concentration of solution and is disposed in contact with one side surface of the pressure adjusting vessel 131b so that the solvent stored in the pressure adjusting vessel 131b flows into the osmotic pressure generating vessel 131a, Expands and pressurizes the drug storage part 120.

Therefore, the osmotic pressure generating vessel 131a is made of a thin and soft elastic material so that it can be easily expanded by the solvent introduced from the pressure regulating vessel 131b.

The pressure regulating vessel 131b is made of an elastic material similar to the osmotic pressure generating vessel 131a and stores a solution having a lower concentration than the solution stored in the osmotic pressure generating vessel 131a in the pressure regulating vessel 131b.

The solvent storage container 131c is located on one side of the pressure control container 131b and stores a large amount of solvent that forms the solution stored in the pressure control container 131b.

The tube 132 is provided with a first tube 132a and a second tube 132b.

The first tube 132a connects the osmotic pressure generating vessel 131a and the pressure regulating vessel 131b so that the solvent stored in the pressure regulating vessel 131b is moved to the osmotic pressure generating vessel 131a.

The second tube 132b connects the pressure regulating vessel 131b and the solvent reservoir 131c to move the solvent stored in the pressure regulating vessel 131b to the osmotic pressure generating vessel 131a.

The semi-permeable membrane 133 is disposed inside the first tube 132a and the second tube 132b, and is made of a porous membrane that allows the solvent constituting the solution to pass therethrough and the solute such as a polymer material and ions to pass.

The osmotic pressure is generated by the semipermeable membrane 133 located inside the tube 132 because the solutions stored in the respective vessels 131 store different concentrations.

The opening and closing control means 134 is disposed inside the second tube 132b and adjusts the opening degree of the second tube 132b so that the amount of the solvent stored in the solvent storage container 131c moves through the second tube 132b .

In the embodiment of the present invention, the opening and closing control means 134 may be a solenoid valve.

The measuring unit 140 measures the internal pressure of the osmotic pressure generating vessel 131a and the pressure regulating vessel 131b, the amount of the solvent injected into the osmotic pressure generating vessel 131a from the pressure regulating vessel 131b, The injection pressure of the drug to be measured, and the like.

The controller 150 receives the status information from the measuring unit 140 and adjusts the opening degree of the opening / closing controller 134 according to the status information.

The manipulation part 160 is a part for manipulating the control part 150 for controlling the injection pressure and the injection speed of the drug discharged to the drug discharge port 121 according to the case where the osmotic drug injection pump 100 is manually operated, The opening degree of the opening / closing control means 134 is manually controlled through a predetermined button and a display device provided in the controller 160.

In one embodiment, the solution stored in the pressure regulating vessel 131b is a solution having a concentration lower than that of the solution stored in the osmotic pressure generating vessel 131a. Therefore, osmotic pressure causes the first semi- Only the solvent stored in the osmotic pressure generating vessel 131b moves to the osmotic pressure generating vessel 131a.

At this time, when the solvent is excessively moved from the pressure regulating vessel 131b to the osmotic pressure generating vessel 131a, the concentration in the osmotic pressure generating vessel 131a is rapidly lowered and the concentration of the solution in the pressure regulating vessel 131b is increased, The movement of the solvent is blocked by the container 131a so that the osmotic pressure generating vessel 131a is no longer inflated and the drug is not supplied to the patient or the body fluid in the patient's body is backwashed to the osmotic drug infusion pump 100 Problems can occur intermittently.

Therefore, when the measurement of the internal pressure of the osmotic pressure generating vessel 131a is performed by the measuring unit 140, the control unit 150 controls the open / close control unit 134 between the pressure control vessel 131b and the solvent storage vessel 131c The solvent in the solvent storage container 131c is supplied to the pressure control container 131b to maintain the internal pressure of the osmotic pressure generating container 131a constant to control the injection pressure of the drug.

It will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Therefore, the embodiments disclosed in the present invention are not intended to limit the scope of the present invention but to limit the scope of the technical idea of the present invention. The scope of protection is to be construed in accordance with the following claims, and all technical ideas within the scope of equivalents thereof should be construed as being included in the scope of the present invention.

100: osmotic drug infusion pump
110: Housing
120: drug storage unit
121: Drug outlet
121a: Rejection of foaming agent
130:
131: container
131a: Osmotic pressure generating vessel 131b: Pressure regulating vessel
131c: solvent storage container
132: tube
132a: first tube 132b: second tube
133: Semipermeable membrane
133a: first semipermeable membrane 133b: second semipermeable membrane
134: opening / closing control means
140:
150:
160:

Claims (7)

housing;
A drug reservoir which is disposed inside the housing and stores the drug inside the shrinkable container and has a drug discharge port formed at one side thereof for discharging the drug stored by the pressure;
And a driving unit positioned at one side of the drug storage unit and pressing the drug storage unit when the container is inflated by osmotic pressure
The driving unit includes:
At least two containers in which solutions having different concentrations are stored;
A tube through which the solution stored in the container is transferred by connecting the two or more containers;
A semi-permeable membrane positioned inside the tube and selectively permeating the solvent and the solute in the solution; And
And opening / closing means for adjusting the amount of the solution moving through the tube by adjusting the opening degree of the tube.
The method according to claim 1,
The container may include:
An osmotic pressure generating container disposed in contact with the other side of the drug storage part to store the solvent;
A pressure regulating vessel connected to one side of the osmotic pressure generating vessel with a first tube and storing a solvent having a concentration lower than that of the solvent stored in the osmotic pressure generating vessel; And
And a solvent storage container formed with a second tube on the other side of the pressure control container and connected to the pressure control container and storing the same solvent as the solvent stored in the pressure control container and supplying the same to the pressure control container. An osmotic drug infusion pump.
3. The method of claim 2,
The semi-
A first semipermeable membrane formed on the first tube positioned between the osmotic pressure generating vessel and the pressure regulating vessel and having a porous membrane formed thereon to selectively pass solvent and solute in the solution; And
And a second semipermeable membrane formed at an inlet of the solvent storage unit and selectively forming a solvent and a solute in the solution,
When the osmotic pressure generating vessel expands due to the osmotic pressure generated by the difference in the concentration of the solvent stored in the pressure regulating vessel and the osmotic pressure generating vessel, the drug stored in the drug storage unit is pressurized by the osmotic pressure generating vessel, And the drug is discharged to the drug discharge port.
The method of claim 3,
Wherein the opening /
Wherein the second tube is a solenoid valve that is located in the second tube and opens or blocks the second tube.
5. The method of claim 4,
A measuring unit for measuring at least one of state information of the internal pressure of the pressure control container and the osmotic pressure generating container, the amount of the solvent injected into the osmotic pressure generating container, and the injection pressure of the drug discharged to the drug discharge port; And
And a controller for receiving the measured status information from the measuring unit,
Wherein the controller controls the opening / closing degree of the opening / closing control means so that the injection pressure of the drug discharged to the drug discharge port is kept constant.
6. The method of claim 5,
Further comprising: an operation unit operable to operate the controller such that an injection rate of the drug discharged to the drug discharge port is adjusted.
The method of claim 1,
Wherein the medicament discharge port further comprises bubble rejection means for removing bubbles generated when the drug is discharged from the drug storage portion to the drug discharge port.

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