KR20150060316A - An antibacterial and antifungal agent for building interior and a building interior comprising the same - Google Patents

Abstract

In the present invention, provided are a novel functional antibacterial and antifungal agent and an antibacterial and antifungal interior material for buildings including the same like gypsum board and foundation paper and wall paper of the gypsum board wherein the provided antibacterial and antifungal agent for interior materials for buildings is made from at least one selected from a group consisting potassium 2-biphenylate and 1,2-benzoisothiazole.

Description

[0001] The present invention relates to an antimicrobial and antifungal agent applicable to architectural interior materials and an interior material containing the antifungal agent and antifungal agent,

The present invention relates to a novel functional antimicrobial and antifungal agent and a building interior material comprising the same, in particular a gypsum board, a gypsum board, and a wallpaper.

It is no exaggeration to say that research on functional additives (antimicrobial, antifungal agent, etc.) for architectural interior materials is not systematic in Korea. Antimicrobial and antifungal agents for building interior materials are used in people's living spaces. Therefore, environmental safety must be ensured in the manufacturing process, and additives that ensure human bio-safety as materials applied to human living spaces should be used. However, functional additive materials for antimicrobial and antifungal agents added to existing building interior materials mainly contain preservatives and insecticides (eg, Thiram, Iso-Thiazoline, etc.) which are highly toxic to raw materials.

Therefore, it is required to develop a material which is not harmful to human body and is guaranteed environmental safety as antibacterial and antifungal agent for building interior materials.

The object of the present invention is to provide a method for preventing harmful bacteria and fungi from building materials, particularly gypsum board, gypsum board paper, and interior construction wallpaper, It is intended to provide an antibacterial and antifungal agent which is free of harmfulness and ensured of environmental safety.

It is a further object of the present invention to provide a method for inhibiting the generation of harmful bacteria and fungi even after the construction of the building, particularly in a subtropical climate area or in the rainy season or underground, Such as antimicrobial and antifungal gypsum boards, gypsum board mats and wallpaper, which can be applied to the building.

In order to accomplish the above object, the present invention provides a method for producing potassium 2-biphenylate (CAS) having 2-hydroxybiphenyl (CAS No. 90-43-7) No. 13707-65-8), copper pyrithione (CAS No. 154592-20-8), and 1,2-Benzisothiazol-3 (2H) -one: CAS NO. 2634-33-5). The present invention also provides a novel functional antibacterial and antifungal agent comprising at least one member selected from the group consisting of:

Further, since the present invention is composed of a mixture of sodium pyrithione (CAS No. 3811-73-2) and sodium 2-biphenylate (CAS No. 132-27-4) , Antibacterial and antifungal agents with improved antibacterial and antifungal performance. In the antimicrobial and antifungal agent of the present invention comprising a mixture of the sodium pyrocite and the sodium 2-biphenylate, the mixing ratio of the sodium pyricion and the sodium 2-biphenylate is in the range of 1: Bismuth: sodium: 2-biphenylate = 1: 2.5 to 3.0. If the mixing ratio is out of the above range, a chemical reaction may occur with the gypsum slurry and other additives added in the preparation of the pulp slurry.

In the present invention, the antimicrobial and antifungal agent may be used as a hydrophilic compound form, or may be used as a salt form of a corresponding compound in consideration of the convenience of work and the compatibility with a raw material for building to be applied. It is preferable to use antibacterial and antifungal agents having improved solubility.

In the present invention, the above potassium 2-biphenylylate, copper pyrithione and 1,2-benzisothiazole may be used singly or in admixture of two or more, They can also be used in combination with antifungal agents. Generally, antimicrobial agents and antifungal agents can be used to prevent the propagation of various kinds of bacteria and fungi by selecting and using antimicrobial and antifungal agents because the active ingredients of bacteria and fungi can be different from each other. It becomes. For this reason, the antibacterial and antifungal agents of the present invention can be used alone, but the antibacterial and antifungal effects can be increased several times by more efficient combination than the sole use. Existing antibacterial and antifungal components that can be used in combination with the antibacterial and antifungal agents of the present invention include sodium pyrithione (CAS No. 3811-73-2), sodium 2-biphenylate 2-biphenylate (CAS No. 132-27-4), and the like, but the present invention is not limited thereto.

The method for applying the antimicrobial and antifungal agent of the present invention to a building interior material is not particularly limited and may be added together during the step of adding additives in the process of manufacturing the interior material. In addition, there is no particular limitation on the formulations to be applied. For example, in order to uniformly disperse the antibacterial and antifungal agent in the interior material composition or the raw slurry in the process of manufacturing a building interior material such as a gypsum board, a gypsum board, It is preferable to be applied as a liquid form preparation which is easy to mix with. As described above, the antimicrobial and antifungal agent is uniformly dispersed in the raw material composition, the raw material slurry or the raw pulp slurry of the building interior material by the use of the liquid antimicrobial and anti-fungal agent, , The stability is excellent, and the antibacterial and antifungal effect can be maintained for a long time. In addition, the liquid antimicrobial and antifungal agents can be simplified in terms of mixing and the like as compared with the powder type, and also have advantages such as cost reduction.

When the antibacterial and antifungal agent of the present invention is applied to a building interior material, the amount of the antibacterial and antifungal agent to be added may vary depending on the type of antimicrobial and antifungal agent and the composition of the composition. The weight of the interior material composition or raw slurry or raw pulp slurry 0.001 to 2.0% by weight, preferably 0.005 to 1.5% by weight, is suitable. If the amount is less than 0.001% by weight, the antibacterial and antifungal effects may be insufficient. If the amount is more than 2% by weight, it is not preferable as a functional additive quantitatively and economically.

The present invention also provides a building interior material, particularly a gypsum board, a gypsum board, and a wallpaper, containing the antibacterial and antifungal agent of the present invention.

The antimicrobial and antifungal building interior materials according to the present invention, in particular, the gypsum board, the gypsum board and the wallpaper, can be obtained by adding the antibacterial and antifungal agent of the present invention to gypsum slurry, gypsum board pulp slurry or wallpaper pulp slurry, The mixture may be stirred and mixed at a stirring speed of 100 to 500 rpm / min to prepare a final product according to a conventional production process.

In addition to the antibacterial and antifungal agents of the present invention, various functional additives may be added to the antibacterial and antifungal building materials of the present invention. For example, in the case of a gypsum board, additives such as a hardener, a dispersant, and a water reducing agent may be used.

According to the present invention, it is possible to provide a building interior material such as a gypsum board, a gypsum board, and a wallpaper which can effectively inhibit noxious bacteria and fungi for a long period of time by containing new antibacterial and antifungal functional ingredients. In addition, when the antibacterial and antifungal agent of the present invention is applied, it is possible to shorten the working time because additional work for imparting antibacterial and antifungal property is not required after the construction interior material is applied, Can be obtained.

1 is a photograph showing the results of Test Example 1 of the present invention.
Fig. 2 is a photograph showing the results of Example 9 to Example 9 of the present invention. Fig.

EXAMPLES The following examples and comparative examples are intended to further illustrate the present invention but are not to be construed to limit the scope of the present invention. It will be obvious.

[ Example  And Comparative Example ]

Table 1 shows the types of antibacterial and antifungal agents used in the following examples and comparative examples, and the compositions of antibacterial and antifungal agents of each of the examples and the comparative examples are shown in Table 2 below.

Abbreviation Antibacterial and antifungal agents Chemical name constitutional formula

K-OPP
Potassium
2-biphenylate

CuPT
Copper pyricion

Na-OPP

Sodium
2-biphenylate

　

BIT

1,2-benzisothiazole

NPT
Sodium pyricion

　

Antibacterial and antifungal agents Amount of active ingredient added
(In 1kg of gypsum board) Example 1 K-OPP 30 mg Example 2 CuPT 30 mg Example 3 K-OPP + Na-OPP mixture 20 mg + 20 mg Example 4 CuPT + Na-OPP mixture 20 mg + 20 mg Example 5 K-OPP + NPT mixture 20 mg + 20 mg Example 6 CuPT + NPT mixture 20 mg + 20 mg Example 7 K-OPP + Na-OPP + NPT mixture 10 mg + 10 mg + 10 mg Example 8 CuPT + Na-OPP + NPT mixture 10 mg + 10 mg + 10 mg Example 9 Na-OPP + NPT mixture   20 mg + 20 mg Comparative Example 1 No additives - Comparative Example 2 NPT 30 mg Comparative Example 3 Na-OPP 30 mg

Test Example  One

Murray P. R., Baron E. J., Pfaller M. A., Tenover F. C., and Yolke R.H. (1999), Manual of clinical microbiology, 7th ed. ed. ASM, Washington, DC. Antifungal activity assay was performed according to the method.

One species of fungi isolated from Aspergillus niger (ATCC 9642), Penicillium phytoplasma (ATCC 11797), Chitomium globosomes (ATCC 6205) and gypsum board was subcultured and transferred to the National Fisheries Research and Development Institute Fungal spore suspension was prepared according to '2013-13 Fungicide Disinfectant Effectiveness Test' and uniformly applied to a PDA (potato dextrose agar) medium. In order to measure antifungal activity, 20 μl of the antibacterial and antifungal agents of Example 9 and Comparative Examples 1 to 3 was added dropwise to a sterilized paper disc (diameter 5 mm, Advantec, Japan) , And the inhibitory rings produced after culturing at 30 ° C were measured. Antifungal efficacy measurements were quantified as inhibition and resistance. The inhibition ring is the size of the clear zone (the distance between the paper disk and the mold) in the form of a round band that inhibits the mold formed on the edge of the paper disk. Resistance indicates the degree of fungus growth on the surface of the paper disk as 0 to 4, and the lower the value, the better the mold resistance (0: 0%, 1: 10%, 2:10 to 30 %, 3: 30 ~ 60%, 4: 60% ~ total area). Observations for each type of fungus are shown in Tables 3, 4, 5 and 6 below.

Antifungal efficacy against Aspergillus niger (ATCC 9642) Amount of antibacterial and antifungal agent added
(In 1kg of gypsum board) sample Inhibition circle Resistance 200 mg Example 9 10 0 Comparative Example 1 0 4 Comparative Example 2 2 0 Comparative Example 3 One 0 100 mg Example 9 2.5 0 Comparative Example 1 0 4 Comparative Example 2 One 0 Comparative Example 3 0 0 44 mg Example 9 One 0 Comparative Example 1 0 4 Comparative Example 2 0 0 Comparative Example 3 0 0 20 mg Example 9 0.5 0 Comparative Example 1 0 4 Comparative Example 2 0 One Comparative Example 3 0 One

Antifungal efficacy against Penicillium pyrophyllus (ATCC 11797) Amount of antibacterial and antifungal agent added
(In 1kg of gypsum board) sample Inhibition circle Resistance 200 mg Example 9 12 0 Comparative Example 1 0 4 Comparative Example 2 2 0 Comparative Example 3 2 0 100 mg Example 9 2 0 Comparative Example 1 0 4 Comparative Example 2 One 0 Comparative Example 3 0 0 44 mg Example 9 2 0 Comparative Example 1 0 4 Comparative Example 2 0.5 0 Comparative Example 3 0 One 20 mg Example 9 2 0 Comparative Example 1 0 4 Comparative Example 2 0.5 0 Comparative Example 3 0 2

Antifungal efficacy against Chlamydia globosom (ATCC 6205) Amount of antibacterial and antifungal agent added
(In 1kg of gypsum board) sample Inhibition circle Resistance 200 mg Example 9 9 0 Comparative Example 1 0 4 Comparative Example 2 1.5 0 Comparative Example 3 One 0 100 mg Example 9 5 0 Comparative Example 1 0 4 Comparative Example 2 One 0 Comparative Example 3 One 0 44 mg Example 9 2.5 0 Comparative Example 1 0 4 Comparative Example 2 0.5 0 Comparative Example 3 0 2 20 mg Example 9 One 0 Comparative Example 1 0 4 Comparative Example 2 0 One Comparative Example 3 0 One

Antifungal efficacy against fungi separated from gypsum board Amount of antibacterial and antifungal agent added
(In 1kg of gypsum board) sample Inhibition circle Resistance 200 mg Example 9 3.5 0 Comparative Example 1 0 4 Comparative Example 2 0 0 Comparative Example 3 1.5 0 100 mg Example 9 2 0 Comparative Example 1 0 4 Comparative Example 2 One 0 Comparative Example 3 0.5 0 44 mg Example 9 One 0 Comparative Example 1 0 4 Comparative Example 2 0 One Comparative Example 3 0 2 20 mg Example 9 One 0 Comparative Example 1 0 4 Comparative Example 2 0 2 Comparative Example 3 0 3

Test Example  2

To investigate the Minimum Inhibition Concentration (MIC) of Na-OPP, NPT and mixtures thereof, Pfaller M A; Boyken L; Hollis R J; | Journal of Clinical Microbiology v.47 no.10, pp.3323-3325, 2009.

Four fungal spore suspensions and antimicrobial and antifungal agents of Example 9 and Comparative Examples 1 to 3 were added to the sterilized RPMI 1640 broth medium and incubated at 30 ° C for 2 to 3 days to obtain 50% The concentration indicating mortality was defined as MIC. The Synergism Index (SI) is described in F. C Kull, P. C. Eisman, H. D. Sylwestrowicz, R. L. Mayer; Applied Microbiology 9, 538-541, 1961.

As a result of the test, it was confirmed that when a mixture of Na-OPP and NPT was used, a remarkably improved effect could be obtained as compared with a simple addition of the effects of each of these alone.

Test Example  3

Gypsum board specimens were prepared by applying the antimicrobial and antifungal agents of each of the examples and the comparative examples, and in order to test the antifungal efficacy, the test pieces were immersed in an incubator having a humidity of 95% and a temperature of 35 ° C And the occurrence of fungi on the surface of the gypsum board was observed over time. The results are shown in Table 8 below.

Date of occurrence of mold Fungal occurrence 1 week 2 weeks 3 weeks 4 weeks 5 weeks Example 1 11th 0 One One One 2 Example 2 18 0 0 One One One Example 3 24th 0 0 0 One One Example 4 Not occurring 0 0 0 0 0 Example 5 25th 0 0 0 One One Example 6 30 days 0 0 0 0 One Example 7 Not occurring 0 0 0 0 0 Example 8 Not occurring 0 0 0 0 0 Example 9 Not occurring 0 0 0 0 0 Comparative Example 1 2 days One 2 4 4 4 Comparative Example 2 10 days 0 One One One One Comparative Example 3 9th 0 One One 2 2

(Note) Criteria for the occurrence of fungi

0: No mold

1: Less than 1/4 area of fungi

2: Fungal area 1/4 to 2/4

3: Fungal area 2/4 to 3/4

2: mold area 3/4 or more

Test Example  4

The gypsum board specimens were prepared by applying antibacterial and antifungal agents of the respective Examples and Comparative Examples, and the test was conducted for 4 weeks by the test method based on ASTM G21 'Procedure for measuring resistance to fungi of synthetic polymer materials'. Fungal species include, but are not limited to, Aspergillus niger (ATCC 9642), Penicillium pyrophillis (ATCC 11797), Glycidium virans (ATCC 9645), Coethionium globosium (ATCC 6205), Aureobasidium (ATCC 15233) were mixed and tested. Observation results after 4 weeks are shown in Table 9 below.

1 week 2 weeks 3 weeks 4 weeks Resistance Inhibition circle Resistance Inhibition circle Resistance Inhibition circle Resistance Inhibition circle Example 1 0 7 0 5 0 4 0 0 Example 2 0 10 0 7 0 0 0 0 Example 3 0 10 0 10 0 9 0 8 Example 4 0 13 0 13 0 13 0 10 Example 5 0 13 0 11 0 10 0 8 Example 6 0 15 0 15 0 14 0 10 Example 7 0 15 0 15 0 15 0 13 Example 8 0 20 0 20 0 20 0 18 Example 9 0 18 0 17 0 17 0 17 Comparative Example 1 4 0 4 0 4 0 4 0 Comparative Example 2 0 12 0 10 0 8 0 2 Comparative Example 3 0 11 0 5 0 2 0 0

(Note) Criteria for the occurrence of fungi

Resistance: The degree (area) of mold growth on the surface of the test specimen is expressed as 0 ~ 4, and the lower the value, the more excellent the antifungal effect.

(0: 0%, 1: 10%, 2: 10 to 30%, 3: 30 to 60%, 4: 60%

Inhibition circle: Round zone-shaped clear zone to prevent mold formation on the edge of specimen (distance between specimen and mold: mm)

Claims (9)

Wherein the antimicrobial and antifungal agent is at least one selected from the group consisting of potassium 2-biphenylate, copper pyrocite, and 1,2-benzisothiazole. The antibacterial and antifungal agent according to claim 1, further comprising at least one member selected from the group consisting of sodium pyricion and sodium 2-biphenylate. An antimicrobial and antifungal agent for building interior materials comprising a mixture of sodium pyricion and sodium 2-biphenylate. 4. The antimicrobial and antifungal agent according to any one of claims 1 to 3, wherein the antibacterial and antifungal agent is a liquid. A building interior material containing the antimicrobial and antifungal agent according to any one of claims 1 to 3. The building interior material according to claim 5, wherein the building interior material is a gypsum board, a gypsum board or a wallpaper. [6] The building interior material according to claim 5, wherein the building interior material comprises 0.001 to 2.0% by weight of the antibacterial and antifungal agent based on the weight of the building interior material. The building interior material according to claim 7, wherein the building interior material contains 0.005 to 1.5 wt% of the antibacterial and antifungal agent based on the weight of the building interior material. [7] The building material according to claim 5, wherein the building interior material is prepared by adding the antibacterial and antifungal agent to a raw material composition for construction use, a raw material slurry or a raw pulp slurry, followed by stirring at a stirring speed of 100 to 500 rpm / Interior materials for construction.

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