KR20150042999A - Composition of Skin Soothining Cosmetics for Acne Skin Using Eco-friendly Supercritical Lavender Extract - Google Patents

Composition of Skin Soothining Cosmetics for Acne Skin Using Eco-friendly Supercritical Lavender Extract Download PDF

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KR20150042999A
KR20150042999A KR20130121907A KR20130121907A KR20150042999A KR 20150042999 A KR20150042999 A KR 20150042999A KR 20130121907 A KR20130121907 A KR 20130121907A KR 20130121907 A KR20130121907 A KR 20130121907A KR 20150042999 A KR20150042999 A KR 20150042999A
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skin
lavender extract
lavender
composition
supercritical
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신문삼
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을지대학교 산학협력단
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/005—Preparations for sensitive skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0203—Solvent extraction of solids with a supercritical fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof

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  • Life Sciences & Earth Sciences (AREA)
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  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

The present invention relates to a cosmetic and sanitary aid composition for sensitive skin containing a supercritical lavender extract, and more specifically, to a composition for sensitive skin, which shows excellent skin soothing effect when containing a lavender extract having high polyphenol and flavonoid contents. The composition comprises 0.1 to 30.0 wt% of the lavender extract which is extracted from lavender leaves by using ethanol.

Description

초임계 라벤더추출물을 함유한 여드름 적합 피부용 피부진정 화장품 조성물{ Composition of Skin Soothining Cosmetics for Acne Skin Using Eco-friendly Supercritical Lavender Extract}Technical Field [0001] The present invention relates to a cosmetic composition for skin suitable for acne containing supercritical lavender extract,

본 발명은 여드름 적합 피부를 위한 친환경 초임계 라벤더추출물을 함유한 화장품 조성물에 관한 것으로 기존의 수열추출법에 비하여 다량의 폴리페놀 함량과 플라보노이드 함량을 지녀 피부진정효과에 있어 상승효과가 탁월한 화장품, 의약외품 조성물에 관한 것이다. The present invention relates to a cosmetic composition containing an environmentally-friendly supercritical lavender extract for acne-compatible skin, which comprises a polyphenol content and a flavonoid content in a large amount compared with the conventional hydrothermal extraction method, and is excellent in cosmetic and quasi-composition .

천연물질에 많은 유효성분들을 많이 함유하고 있고 이러한 약효성분을 추출하기 위한 많은 연구가 진행되었다. 천연물질에서 유효물질을 추출할 때 수열추출법을 많이 사용되고 있지만, 물의 끊는 점까지 가열하여 열에 약한 유효물질이 파괴될 수 있고, 물에 용해되지 않는 유효성분은 추출할 수 없는 단점을 지니고 있다. There are many active ingredients in natural materials and many studies have been conducted to extract these active ingredients. Although the hydrothermal extraction method is widely used for extracting effective substances from natural materials, it is disadvantageous in that effective substances weak to heat can be destroyed by heating up to the point where water is broken, and active ingredients which are not dissolved in water can not be extracted.

천연물질에서 유효성분을 추출하기 위한 다른 방법으로 인체에 유해성이 적은 에탄올을 이용하는 추출방법이 있는데, 이것을 추출효율은 좋고, 열에 의한 유효물질이 파괴되지 않는 좋은 장점을 지니고 있다. Another method for extracting an active ingredient from a natural substance is an extraction method using ethanol which is less harmful to the human body. This extraction efficiency is good and has a merit that the effective substance by heat is not destroyed.

이에, 본 발명자들은 기존의 수열추출법을 사용하지 않고, 초임계 이산화탄소를 이용하여 저온에서 추출하여 라벤더 추출물에서 유효성분을 추출하고자 하였고, 이를 이용하여 민감성 피부를 위한 피부진정 효과를 나타내는 장점을 지니고 본 발명을 완성하게 되었다.
Therefore, the present inventors tried to extract an active ingredient from a lavender extract by using supercritical carbon dioxide at a low temperature without using a conventional hydrothermal extraction method, and it has an advantage of showing a skin soothing effect for sensitive skin using Thereby completing the invention.

본 발명에서는 물의 끊는 점까지 가열하여 열에 약한 유효물질이 파괴될 수 있고, 물에 용해되지 않는 유효성분은 추출할 수 없는 단점을 지닌 수열추출법을 보강한 에탄올을 이용하여 추출효율이 좋은 민감성 피부를 위한 피부진정 효과를 나타내는 라벤더추출물을 추출하여 화장품 제형을 완성하고자 하였다.
In the present invention, it is possible to use an ethanol-enhanced hydrothermal extraction method which has the disadvantage that the effective substance which is weak to heat can be destroyed by heating up to the breaking point of water and the active ingredient which is not dissolved in water can not be extracted, And extracts of lavender extracts for skin soothing effect.

본 발명에 의한 라벤더추출물을 함유한 민감성 피부를 위한 피부진정효과를 위한 것으로, 에탄올을 이용하여 라벤더 잎에서 추출한 라벤더추출물을 0.1 내지 30.0 중량 %포함하고 있는 것을 특징으로 한다.
The present invention provides a skin soothing effect for sensitive skin containing the lavender extract according to the present invention, which comprises 0.1 to 30.0% by weight of a lavender extract extracted from lavender leaves using ethanol.

본 발명에서는 민감성 피부를 위한 초임계 라벤더추출물을 함유하며 피부진정 효과를 나타낼 수 있었고, 이것은 수열추출법이나 다른 성분에 비하여 더욱 많은 폴리페놀함량과 플라보노이드 함량은 나타내며, 더 좋은 피부진정효과를 나타낼 수 있었다.
In the present invention, supercritical lavender extract for sensitive skin was able to exhibit skin soothing effect, and it exhibited more polyphenol content and flavonoid content than hydrothermal extraction method and other ingredients, and showed better skin soothing effect .

본 발명의 조성물에서 유효성분인 초임계 라벤더추출물을의 제조는 다음과 같다. 먼저, 라벤더잎을 정제수로 세척하고 음지에서 자연 건조시킨 후 분쇄기를 이용하여 분쇄한다. 분쇄된 라벤더잎을 각각 반응기에 넣고 100기압으로 초임계 이산화탄소를 이용하여 추출한 후 3회 반복하여 여과한다. 열수추출법나 유기용매 추출법보다 초임계 추출법을 선택한 이유는 열수추출법에서는 물에 용해되는 유효성분이 작고, 끊는 물에 의해 유효성분이 파괴될 수 있는 위험성이 있고, 유기용매는 추출효율은 좋지만 잔존 유기용매로 인한 부작용이 우려되기 때문이다.      The preparation of the supercritical lavender extract as an active ingredient in the composition of the present invention is as follows. First, lavender leaves are washed with purified water, dried naturally on shade, and ground using a pulverizer. Each of the pulverized lavender leaves is put into a reactor, extracted with supercritical carbon dioxide at 100 atm, and filtered repeatedly three times. The reason for choosing supercritical extraction method over hydrothermal extraction method or organic solvent extraction method is that there is a danger that the effective ingredient dissolved in water is small in the hot water extraction method and the active ingredient can be destroyed by the water which is broken and the organic solvent has good extraction efficiency, This is because of concerns about side effects.

본 발명에 따는 초임계 라벤더추출물은 더욱 많은 폴리페놀함량과 플라보노이드 함량은 나타내며, 더 좋은 피부진정 효과를 나타낼 수 있음을 확인하여 본 발명을 완성하고자 하였다.     The supercritical lavender extract according to the present invention shows a greater polyphenol content and flavonoid content and can exhibit a better skin soothing effect, thus completing the present invention.

본 발명의 여드름등 민감성 피부를 위한 화장료 조성물은 통상적으로 제조되는 로션, 크림 제형으로 제조될 수 있다. 이하 본 발명의 이해를 돕기 위하여 바람직한 실시한 예를 제시한다. 그러나 하기의 실시한 예는 본 발명을 더욱 쉽게 이해하기 위하여 제공되는 것일 뿐, 실시한 예에 의해 본 발명의 내용이 한정하는 것은 아니다.
The cosmetic composition for sensitive skin such as acne of the present invention can be prepared into a conventionally prepared lotion or cream formulation. Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided to further understand the present invention, and the present invention is not limited by the examples.

실시예 1 : 초임계 라벤더추출물의 제조Example 1: Preparation of Supercritical Lavender Extract

라벤더 잎을 정제수로 세척하고 음지에서 자연 건조한 후 분쇄기를 이용하여 2~3 cm의 크기로 분쇄한다. 분쇄된 라벤더 1kg을 반응기에 넣고, 초임계 이산화탄소를 충진하여 100기압으로 35 ℃에서 24시간 동안 추출하였다. 상기 추출물을 와트만 3번 여과지로 여과하고 나서, 상압으로 감압하여 라벤더추출물을 38.3 g을 얻었다.
Lavender leaves are washed with purified water, dried naturally in shade, and then pulverized to a size of 2 to 3 cm using a pulverizer. 1 kg of pulverized lavender was put into a reactor, supercritical carbon dioxide was charged, and the mixture was extracted at 35 ° C for 24 hours at 100 atm. The extract was filtered with a filter paper of No. 3 Wattman and then decompressed under normal pressure to obtain 38.3 g of a lavender extract.

실시예 2. 라벤더추출물의 총 폴리페놀 함량 측정Example 2. Measurement of total polyphenol content of lavender extract

라벤더추출물의 총 폴리페놀 함량은 Folin-Denis법을 변형하여 측정하였다. Methanol에 1 ㎎/㎖ 농도로 용해시킨 시료액 80 ㎕와 Folin-Denis reagent 80 ㎕를 혼합하여 3분간 반응시킨 뒤 10% Na2CO3 80 ㎕를 혼합하여 60분 동안 암실에서 반응시킨 후, 상등액 120 ㎕를 취하여 96 well plate에 옮겨 700 ㎚에서 흡광도를 측정하였다. 표준 곡선은 표준물질인 tannic acid를 이용하여 polyphenol의 함량을 구하였다. 라벤더추출물의 총 폴리페놀의 함량은 33.9 mg/100g로 더 많은 폴리페놀 함량을 지니고 있다.
The total polyphenol content of the lavender extract was determined by modifying the Folin-Denis method. 80 μl of the sample solution dissolved in methanol at a concentration of 1 mg / ml and 80 μl of the Folin-Denis reagent were mixed and reacted for 3 minutes. Then, 80 μl of 10% Na 2 CO 3 was mixed and reacted in a dark room for 60 minutes. 120 μl was transferred to a 96-well plate and absorbance was measured at 700 nm. The content of polyphenol was determined using standard tannic acid as a standard curve. The total polyphenol content of the lavender extract is 33.9 mg / 100 g and has a higher polyphenol content.

실시예 3. 추출물의 총 플라보노이드 함량 측정Example 3. Measurement of total flavonoid content of extract

라벤더추출물의 함량의 플라보노이드 함량은 Davis 등의 방법을 변형하여 측정하였다. 1 ㎎/㎖ 농도로 methanol에 용해시킨 시료액 10 ㎕와 1N-NaOH 10㎕, dietyleneglycol 200 ㎕를 혼합하여 37℃ slide warmer에서 60분 동안 반응시킨 후 420 ㎚에서 흡광도를 측정하였다. 표준곡선은 표준물질 rutin을 이용하여 flavonoid 함량을 구하였다. 라벤더추출물의 총 플라보노이드의 함량은 36.5 mg/100g로 더 많은 플라보노이드 함량을 지니고 있다.
The flavonoid content of the lavender extract was measured by the modified method of Davis et al. 10 μl of the sample solution dissolved in methanol at a concentration of 1 mg / ml, 10 μl of 1N NaOH and 200 μl of diethyleneglycol were mixed and reacted for 60 minutes at 37 ° C in a slide warmer, and the absorbance was measured at 420 nm. For the standard curve, the flavonoid content was determined using the standard substance rutin. The total flavonoid content of the lavender extract is 36.5 mg / 100 g, which has a higher content of flavonoids.

실시예 4. 피부진정효과시험        Example 4. Skin Soothing Test

피부진정효과를 측정하기 위하여, 비교예시는 살리실산을 0.5% 함유한 계면활성제를 10% 함유한 클렌저 제형이고, 실시예시 1번은 비교예시의 제형에서 라벤더추출물을 1.0% 함유한 제형이다. 이 2가지 제형을 20~40대의 건강한 성인 남녀 30명 (남자-15명, 여자-15명)을 대상으로 윗 팔뚝 부위에 격일로 총 9회의 24시간 누적사용하고 한 후에 첩포를 시행하고 각각 자외선-A, 자외선-B를 각각 3분간 주사하여,자외선 노출과 활성산소, 광독성의 영향을 측정하였다. 첩포방법은 핀 챔버(Finn Chamber, Epitest, Ltd, 핀란드)를 이용하였다. 챔버에 상기 실시 제조예 3에서 제조한 각 자외선차단제를 15 ㎕씩 적하한 후 자외선-A, 자외선-B를 차례로 각각 3분씩 주사한 후에 첩포를 실시하였다. 매회 피부에 나타난 반응 정도를 하기 수학식을 이용하여 점수화하였다.    In order to measure skin soothing effect, a comparative example is a cleanser formulation containing 10% of a surfactant containing 0.5% salicylic acid. Example 1 is a formulation containing 1.0% of a lavender extract in the formulation of Comparative Example. These two formulations were used in 30 healthy adults (male-15, female-15) in 20- to 40-year-old adults for 9 hours and 24 hours in total on the upper forearm. -A and ultraviolet-B were respectively injected for 3 minutes to measure the effects of ultraviolet exposure, active oxygen and phototoxicity. A pin chamber (Finn Chamber, Epitest, Ltd, Finland) was used as the deposition method. 15 [mu] l of each of the ultraviolet screening agents prepared in Preparation Example 3 was added dropwise to the chamber, and UVA-A and UVA-B were sequentially injected for 3 minutes each time, followed by applying a patch. The degree of skin reaction on each occasion was scored using the following equation.

평균반응도 = {[반응지수×반응도) / (총피검자수×최고점수)] × 100} / 검사횟수Average response rate = {[Reaction index × response) / (total number of subjects × highest score)] × 100} / number of tests

이때, 반응도에서 ±는 1점, +는 2점, ++는 4점의 점수를 부여하며, 평균반응도가 3미만일 때 안전한 조성물로 판정하였다. At this time, ±, 1, 2, and ++ were given a score of ± 1, ± 2, and 4, respectively, and a safe composition was determined when the average degree of reactivity was less than 3.

비교예시 제형에서는 1주만에 반응도가 나타났으며, 평균반응도는 3.3으로 다소 높은 수치를 유지하였지만, 라벤더추출물을 1.0% 함유한 실시예시 1번은 2주가 되어 반응도가 나타났으며, 평균반응도는 0.01을 나타내어 우수한 피부진정효과를 나타냄을 발견하고 본 발명을 완성하게 되었다.
In the comparative example formulation, the reactivity was shown only in one week, and the average reactivity was maintained at a somewhat high value of 3.3. However, in Example 1 containing 1.0% of the lavender extract, the reactivity was shown to be 2 weeks and the average reactivity was 0.01 And exhibits a superior skin-soothing effect, thus completing the present invention.

Claims (1)

여드름 피부 등 민감성 화장품을 위한 피부진정 화장품 조성물에 관한 것으로, 초임계 이산화탄소 추출법을 이용하여 라벤더 잎에서 추출한 라벤더추출물을 0.1 내지 30.0 중량 %를 함유하고 있는 것을 특징으로 하는 라벤더추출물 함유한 피부 진정 민감성 화장료 조성물. The present invention relates to a skin-soothing cosmetic composition for sensitive cosmetics such as acne skin, which comprises 0.1 to 30.0% by weight of a lavender extract extracted from a lavender leaf using a supercritical carbon dioxide extraction method. Composition.
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FR3106754A1 (en) 2020-02-04 2021-08-06 Isp Investments Llc PROCESS FOR OBTAINING AN AQUEOUS LAVENDER EXTRACT, COMPOSITIONS INCLUDING SUCH EXTRACT AND THEIR COSMETIC USES

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3106754A1 (en) 2020-02-04 2021-08-06 Isp Investments Llc PROCESS FOR OBTAINING AN AQUEOUS LAVENDER EXTRACT, COMPOSITIONS INCLUDING SUCH EXTRACT AND THEIR COSMETIC USES
WO2021156104A1 (en) 2020-02-04 2021-08-12 ISP Investments LLC. Method for obtaining an aqueous extract of lavender, compositions comprising such an extract and their cosmetic uses
CN115135301A (en) * 2020-02-04 2022-09-30 Isp投资有限责任公司 Method for obtaining an aqueous extract of lavender, composition comprising such an extract and cosmetic use thereof

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