KR20140064887A - Microneedle patch container - Google Patents
Microneedle patch container Download PDFInfo
- Publication number
- KR20140064887A KR20140064887A KR1020147007274A KR20147007274A KR20140064887A KR 20140064887 A KR20140064887 A KR 20140064887A KR 1020147007274 A KR1020147007274 A KR 1020147007274A KR 20147007274 A KR20147007274 A KR 20147007274A KR 20140064887 A KR20140064887 A KR 20140064887A
- Authority
- KR
- South Korea
- Prior art keywords
- storage container
- micro needle
- patch
- microneedle
- convex portion
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
There is provided a micro needle patch storage container for holding the micro needle patches sanitarily without damaging the effect during use after manufacture of the micro needle patches. The storage container has a bottom surface concave to the center in the center, a side connecting the bottom surface and the peripheral portion, and a bottom surface convexity protruding from the bottom surface, and the release sheet portion of the flexible micro needle patch is held by the bottom surface convex portion . The storage container can be used with a lid having a concave portion for pressing a microneedle patch held on the bottom convex portion at a position corresponding to a part of the bottom convex portion. In order to hold and retain the micro needle patch in an aseptic state, it is preferable to store it in a bag formed of a thin paper or an antibacterial film sheet.
Description
The present invention relates to a storage container for storing a micro needle patch.
Liquid substances, ointments, cream preparations, tape preparations, patch preparations, puff preparations and the like, which contain a pharmaceutical active ingredient, have been used for imparting a modifying effect or a functional effect to the skin surface layer or the skin horny layer. They are intended to exert their effects by infiltrating the medicinal ingredient into the skin by applying or sticking to the surface of the skin. However, when the composition is applied to the skin, the active ingredient is easily lost or eliminated due to sweating action of the skin or external contact with the skin. In addition, the skin has a barrier function of preventing foreign matter from entering the body, and it is difficult to absorb the medicinal ingredient into the skin just by applying or attaching the medicinal ingredient to the skin.
In recent years, these problems have been solved, and micro needle has been developed as a method for surely supplying a medicinally effective ingredient into the skin, and research is being conducted. The micro needle is a minute needle having a length of less than 1 mm (Patent Document 1). When the microneedles are produced by a substance which easily dissolves and disappears in vivo, the entrained microneedles dissolve in the skin, are absorbed and disappear (Patent Document 2). Therefore, if the micro-needle is preliminarily contained with the active ingredient, the active ingredient can be supplied to a specific site in the skin. If a plurality of such micro-needles are arranged on a substrate, the microneedle array becomes a microneedle array, and the amount of transmission can be increased in proportion to the number of needles, so that there can be a great expectation for practical use (Patent Document 2-4, Non-Patent Document 1). In the micro needle array, an adhesive tape for attaching the micro needle array to the skin is added to the micro needle array to make it easy to use.
Since the length of the micro needle is generally shorter than 1 mm and the diameter is about 0.1 mm, it does not feel pain at the time of insertion and there is no bleeding. The entry point is quickly closed, leaving no trace. As a result, it has been recognized that the microneedle is an excellent method of delivering a specific active ingredient to a specific site of the skin. In addition to medical applications such as delivery of a vaccine, microneedles are attracting attention as a cosmetic product for delivering effective ingredients of skin such as hyaluronic acid to the skin surface and for suppressing dots and bruises.
The initial microneedles had about 100 microneedles on a rigid substrate of about 1 cm2. Recently, however, there has been a desire to improve a large part of the face at one time, and a microneedle array having microneedles thereon has been developed so as to soften the substrate and fit on the face rather than on the plane.
In order to supply micro-needle arrays to consumers on the market, proper containers are needed. Since the microneedle array has a needle part and it is necessary to protect the needle part during transportation, sale, and preservation, it is possible to use a conventionally widely used container such as a tape or the like (patent documents 5 and 6) There is no. Further, it is not possible to use a rigid substrate container (Patent Document 7-9) in a microneedle array having a soft substrate.
Since the micro needle patches are used to patch the skin to deliver medicinally active ingredients, they need to be held hygienically and without damaging its efficacy for a period of time after its manufacture through distribution and use. SUMMARY OF THE INVENTION It is an object of the present invention to provide a micro needle patch retractor suitable for holding a micro needle patch in which an adhesive tape is attached to a flexible micro needle array and a release sheet is attached to the adhesive surface, It is in providing the courage.
The microneedle patch storage container according to the present invention which has been made in order to solve the above problems is characterized in that it has one or a plurality of bottom surfaces concave than the peripheral part, a side connecting the bottom surface and the peripheral part, and a bottom surface convex part protruded from the bottom surface, And the release sheet portion of the micro needle patch is held by the bottom convex portion.
One micro needle patch storage container can accommodate as many micro needle patches as the number of the bottom side. Normally, one micro needle patch storage container holds one micro needle patch. However, for example, in the case of a micro needle patch pasted under the eyes, since patches are usually placed under the eyes of right and left eyes, it is preferable for the trade to store two sets of patches.
It is also possible to hold two or more micro needle arrays in one micro needle patch. In this case, two or more microneedle arrays can be accommodated in one container.
The microneedle patch storage container according to the present invention has a concave portion for pressing a micro needle patch held on the bottom convex portion at a position corresponding to a part of the bottom convex portion, It is preferable that the lid having no recess is provided. Although the release sheet portion of the micro needle patch is held on the bottom convex portion, if the concave portion of the lid is formed so as to entirely press it, the micro needle patch is brought into close contact with the lid by the action of the static electricity. If the micro needle patch is attracted to the lid by the static electricity, the micro needle patch suddenly protrudes when the lid is detached, and it is also difficult for the micro needle patch to be attracted to the storage container to be taken out. When the pressing by the concave portion of the lid is partially performed, the influence of the static electricity is weakened and the handling becomes easy, which is preferable. It is preferable that the area of the bottom convex portion is larger than the area of the concave portion of the lid in order to prevent the micro needle patch from being adsorbed on the lid by reducing the influence of the static electricity.
When the bottom convex portion has a substantially rectangular shape, it is preferable that the release sheet of the micro needle can be pressed and held easily. It is also possible to divide the rectangular shape into several pieces so that the plurality of convex portions hold the four sides of the release sheet.
The micro needle patch storage container is preferably capable of stacking a plurality of the containers by fitting them together. For this purpose, it is preferable that the micro needle patch stored in another micro needle patch storage container is partially pressed by the outside of the bottom surface of the micro needle patch.
In order to enhance the cosmetic effect of attaching the micro needle patch to the face and replenishing the hyaluronic acid and the active ingredient to remove the wrinkles, it is usually necessary to apply the patch while wearing it over several days. Therefore, it is preferable for a transaction to be able to package a number of sheets necessary for a series of uses.
It is preferable that the microneedle array is provided with a notch and an ear at the corresponding positions of the storage container and the lid of the storage container so that the lid can be easily separated from the storage container at the time of use. The micro needle patch storage container needs to be sealed from the time of manufacture until immediately before use, but it is necessary to take out the micro needle patch storage container easily when using it.
It is preferable to form an expanded portion on the bottom surface of the micro needle patch storage container so that the micro needle patch can be picked up and taken out easily. This is to make it easy to pick up the micro needle patch even when it is closely attached to the storage container by static electricity.
The microneedle patch storage container according to the present invention is preferably provided with an antistatic treatment on its surface. When the storage container is charged, the micro needle patch is sucked to the storage container and becomes difficult to handle.
The present microneedle patch storage container can hold the microneedles in a hermetically sealed state, but can not necessarily hold them in an aseptic state. In order to hold the micro needles aseptically, it is preferable to sterilize the containers and the micro needles, and then store the containers in a pocket formed by a thin paper or an antibacterial film sheet to seal them. As the antibacterial film sheet, a plastic sheet or an aluminum sheet can be suitably used. The aluminum sheet is particularly preferable because it has high airtightness.
In the case of a so-called adhesive medicine in which the adhesive agent, that is, the active agent ingredient and the adhesive are mixed and spread on a resin film, a release sheet is usually placed on the active ingredient, and the release agent sheet is peeled off before attaching to the skin, It is customary to affix it. In this case, although it is preferable to be clean because it is stuck on the stratum corneum of the skin, sterility is not required because of the barrier effect of the stratum corneum.
In this respect, the necessary conditions for the micro needle patch storage container are more stringent than those required for the patch storage container. Micro-needles must be hygienically preserved as they enter the skin. Further, since the needle can not be inserted into the skin unless it is sharp, it is not possible to strike a hard object which can damage the tip of the needle. Further, since the needle is inserted into the skin, it is not allowed to attach to the body such as a pressure-sensitive adhesive so that it is unknown whether it is safe or not. That is, the microneedles must be retained and retained only in the portion of the release sheet in a state of being in a sterilized state and not in contact with any part of the container. As a result, the micro needle patch storage container necessarily differs structurally from the patch storage container, and can not be designed from the patch storage container.
Further, when the micro needle array is flexible, a method of preserving a rigid micro needle array can not be used as it is. Stiff and flexible are due to different holding methods.
The material of the micro needle patch storage container is not particularly limited, but a resin which is easy to perform injection molding or press working is preferable. Particularly, it is preferable to be transparent or semitransparent because the situation of contents can be seen from the outside. In addition, it is preferable that the permeability of air or water vapor is small so that the micro needle patch can be stably protected over a long period of time. Specifically, polyethylene terephthalate (PET), polypropylene (PP), and polyethylene (PE) are preferable, but PET is particularly preferable because it is less deteriorated or exfoliated by γ-ray or electron beam irradiation sterilization.
According to the microneedle patch storage container of the present invention, the microneedle patch is held by the release sheet portion, and the microneedle portion is not in contact with any portion of the container. Even if the micro needle patch is a flexible sheet, it can be held hygienically until it is opened.
When the storage container is used, the micro needle patch can be easily taken out when necessary. Further, the storage containers can be stacked on each other, so that several micro needle patches necessary for a series of use can be easily packed.
The microneedle patch storage container of the present invention is designed to avoid the influence of static electricity. If there is an influence of the static electricity, the micro needle patch is sucked on the cover and suddenly pops out when the lid is detached, or it becomes difficult to be picked up by the storage container.
1 is a view showing a microneedle patch used in Example 1-3.
2 is a view of a first embodiment of a micro needle patch storage container.
3 is a view of the cover of the microneedle patch storage container of the first embodiment.
4 is a view of a second embodiment of the micro needle patch storage container.
5 is a view of the cover of the microneedle patch storage container of the second embodiment.
6 is a view of a third embodiment of the micro needle patch storage container.
7 is a view of a fourth embodiment of the micro needle patch storage container.
8 is another view of a fourth embodiment of the micro needle patch storage container.
9 is a view of the microneedle array used in the fifth embodiment.
10 is a view of a fifth embodiment of the micro needle patch storage container.
Hereinafter, embodiments of the present invention will be described on the basis of embodiments. The present embodiment is designed to accommodate a micro needle patch designed on the assumption of attaching under the eyes, but if the micro needle array patch of another shape is designed, it may be appropriately changed in design accordingly, and the present invention is not limited to the shape of the embodiment .
The
The size of the microneedles is not limited, but is about 50 to 500 / cm2 of needle having a length of 30 to 1000 mu m. Its main ingredient is hyaluronic acid, but it contains ingredients effective for skin wrinkles and revitalization.
The pressure
The bottom portion of the
When the microneedle patch is used, since a cutting line is formed at the center of the
(Example 1)
An example of a micro needle patch storage container suitable for the micro needle patch described above is shown in Fig. The material is polyethylene terephthalate (PET).
The micro needle
The microneedle
The
In the drawing of the concave portion of the storage container, the upper right and lower left inflated portions are formed to facilitate picking up and taking out the micro needle patch when taking out the micro needle patch from the storage container. Although the micro needle patch is tightly inserted into the storage container, it can be easily picked up by inserting a finger into the expanded portion.
The
There is an
The microneedle
As shown in Figs. 2 and 3, the position of the bottom surface
The
The microneedle
The microneedle patch storage container containing the microneedle patch may be housed in a bag made of the microfiltrated aluminum film sheet after sterilization without holding the cover, and may be hermetically held.
The microneedle patch storage container containing the microneedle patch may be sealed by putting a sterilized paper laminated with a heat sealable film or polyethylene without covering and by fusing the film with the periphery of the storage container by heat sealing.
(Example 2)
Another example of the micro needle patch storage container is shown in Fig. The micro needle
The microneedle
Six side
A
The
There is an
Unlike the case of the first embodiment, the micro needle patch storage container of the present embodiment is only in contact with the side projections so that the micro needle
The concave portion of the lid is formed on the upper and lower sides of the figure but not on the left and right sides. The micro needle patches extend over the bottom protrusions on the right and left sides in Fig. 4, but are not sandwiched from above.
(Example 3)
An example of a micro needle patch storage container capable of accommodating two micro needle patches is shown in Fig. The micro needle
The microneedle
(Example 4)
An example of a micro needle patch storage container capable of accommodating a micro needle patch holding two micro needle arrays is shown in Figs. 7 and 8. Fig. This micro needle patch holds two
By doing so, two micro needle arrays can be accommodated more easily than in the case of Fig.
7 shows a microneedle
In Fig. 7, the broken line indicates an example of the
8 shows a micro needle
8 are examples of the
(Example 5)
Four micro needle arrays are housed in one micro needle patch storage container.
Fig. 9 shows a micro needle array in which a pressure sensitive adhesive sheet is provided only on the periphery of the micro needle array. It is preferable that the adhesive sheet is provided on the side of the microneedle array on which the micronee needle is not provided and the adhesive sheet is not present on the back surface of the microneedle.
A microneedle patch holding four such microneedle arrays on one release sheet is preferable when four microneedle patches are used at a time.
The microneedle
In Fig. 10, the four micro needle arrays shown in Fig. 9 are indicated by broken lines. These are examples when the microneedle patch is housed in a storage container and do not show the structure of the storage container.
10: Micro needle patch
11: Micro needle array
12: Pressure sensitive adhesive sheet
13: release sheet
20, 40: Micro needle patch storage container cover
21, 41: peripheral portion of the cover
22, 42: concave portion of the cover
26, 46: an ear for releasing the engagement between the container and the lid
30, 50: Micro needle patch storage container
31, 52, 61, 71, 81: peripheral portion of the storage container
32, 52, 62, 72, 82: a concave bottom surface
34, 54, 64, 74, 84: bottom convex portions formed in concave portions of the bottom surface
35, 55: side convex portion
38, 58: area
60, 70: Micro needle patch storage container capable of storing two micro needle arrays
68: Micro needle array
69: Adhesive tape
80: Micro needle patch storage container capable of storing four micro needle arrays
87: Micro needle array
88: Micro Needle Patch
Claims (11)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-2011-225328 | 2011-09-22 | ||
JP2011225328A JP5687170B2 (en) | 2011-03-30 | 2011-09-22 | Microneedle patch storage container |
PCT/JP2012/074048 WO2013042723A1 (en) | 2011-03-30 | 2012-09-20 | Microneedle patch container |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20140064887A true KR20140064887A (en) | 2014-05-28 |
KR101990654B1 KR101990654B1 (en) | 2019-06-18 |
Family
ID=50895956
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020147007274A KR101990654B1 (en) | 2011-09-22 | 2012-09-20 | Microneedle patch container |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR101990654B1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017061701A1 (en) * | 2015-10-08 | 2017-04-13 | 주식회사 라파스 | Microneedle patch packaging case |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6063344U (en) * | 1983-10-06 | 1985-05-04 | 丸正金属箔工業株式会社 | Container for poultice |
JPH10511330A (en) * | 1994-12-21 | 1998-11-04 | エシカル・ファーマシューティカル・(ユー.ケイ.)リミテッド | Container to put the patch |
JP3152532B2 (en) | 1993-02-04 | 2001-04-03 | 塩野義製薬株式会社 | Anti-influenza A active cuparan sesquiterpene compound |
JP2002517300A (en) | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | Microneedle devices and methods of manufacture and uses thereof |
JP2003238347A (en) | 2002-02-18 | 2003-08-27 | Nano Device & System Research Inc | Functional micropile and method for producing the same |
JP2006056543A (en) | 2004-08-18 | 2006-03-02 | Kanae Technos:Kk | Gel sheet package for pack |
JP2006346126A (en) | 2005-06-15 | 2006-12-28 | Nabtesco Corp | Dermal needle |
JP2008518042A (en) | 2004-10-07 | 2008-05-29 | アクセス ビジネス グループ インターナショナル エルエルシー | A composition comprising a rosemary (Rosmarinusofficinalis) plant extract, an Alpinia plant extract, and a DNA repair enzyme. |
JP2008284318A (en) | 2007-05-15 | 2008-11-27 | Kosumedei Seiyaku Kk | Microneedle for dosing, including living body origin matter |
JP3152532U (en) * | 2009-04-22 | 2009-08-06 | コスメディ製薬株式会社 | Microneedle patch storage case |
JP2010075485A (en) | 2008-09-26 | 2010-04-08 | Toppan Printing Co Ltd | Microneedle holding vessel |
JP2010075486A (en) | 2008-09-26 | 2010-04-08 | Toppan Printing Co Ltd | Microneedle holding vessel |
-
2012
- 2012-09-20 KR KR1020147007274A patent/KR101990654B1/en active IP Right Grant
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6063344U (en) * | 1983-10-06 | 1985-05-04 | 丸正金属箔工業株式会社 | Container for poultice |
JP3152532B2 (en) | 1993-02-04 | 2001-04-03 | 塩野義製薬株式会社 | Anti-influenza A active cuparan sesquiterpene compound |
JPH10511330A (en) * | 1994-12-21 | 1998-11-04 | エシカル・ファーマシューティカル・(ユー.ケイ.)リミテッド | Container to put the patch |
JP2002517300A (en) | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | Microneedle devices and methods of manufacture and uses thereof |
JP2003238347A (en) | 2002-02-18 | 2003-08-27 | Nano Device & System Research Inc | Functional micropile and method for producing the same |
JP2006056543A (en) | 2004-08-18 | 2006-03-02 | Kanae Technos:Kk | Gel sheet package for pack |
JP2008518042A (en) | 2004-10-07 | 2008-05-29 | アクセス ビジネス グループ インターナショナル エルエルシー | A composition comprising a rosemary (Rosmarinusofficinalis) plant extract, an Alpinia plant extract, and a DNA repair enzyme. |
JP2006346126A (en) | 2005-06-15 | 2006-12-28 | Nabtesco Corp | Dermal needle |
JP2008284318A (en) | 2007-05-15 | 2008-11-27 | Kosumedei Seiyaku Kk | Microneedle for dosing, including living body origin matter |
JP2010075485A (en) | 2008-09-26 | 2010-04-08 | Toppan Printing Co Ltd | Microneedle holding vessel |
JP2010075486A (en) | 2008-09-26 | 2010-04-08 | Toppan Printing Co Ltd | Microneedle holding vessel |
JP3152532U (en) * | 2009-04-22 | 2009-08-06 | コスメディ製薬株式会社 | Microneedle patch storage case |
Non-Patent Citations (1)
Title |
---|
권영숙, 가미야마 후미오, 「마이크로니들 제품화에 대한 도정」약제학, 사단 법인 일본 약제학회, 2009년 4월, 제69권, 제4호, p.272-276 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017061701A1 (en) * | 2015-10-08 | 2017-04-13 | 주식회사 라파스 | Microneedle patch packaging case |
Also Published As
Publication number | Publication date |
---|---|
KR101990654B1 (en) | 2019-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5687170B2 (en) | Microneedle patch storage container | |
JP5947873B2 (en) | Microneedle patch storage container 2 | |
EP3240732B1 (en) | Individually sealed antiseptic applicators | |
US3774609A (en) | Surgical preparatory applicator | |
US10561831B2 (en) | Transdermal administration device packaged body | |
JP3152532U (en) | Microneedle patch storage case | |
KR101316033B1 (en) | The blister package | |
KR20150028248A (en) | Protective release sheet for microneedle patch | |
JP6020771B2 (en) | Transdermal administration device and method for producing transdermal administration device | |
JP3179380U (en) | Storage container for two microneedle patches | |
CA2902389C (en) | Package for medical product | |
KR101990654B1 (en) | Microneedle patch container | |
ES2848855T3 (en) | Blister strip | |
US20210052825A1 (en) | Pen needle cover | |
CN215129163U (en) | Disposable liver puncture biopsy package | |
CN208585535U (en) | A kind of microneedle patch inner packaging box | |
CN217865928U (en) | Microneedle patch packaging body and microneedle patch product | |
JP2023175354A (en) | Microneedle protective material and puncture method using microneedle | |
CN110678103A (en) | Multi-purpose non-contact applicator with reservoir |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant |