KR20140064887A - Microneedle patch container - Google Patents

Microneedle patch container Download PDF

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Publication number
KR20140064887A
KR20140064887A KR1020147007274A KR20147007274A KR20140064887A KR 20140064887 A KR20140064887 A KR 20140064887A KR 1020147007274 A KR1020147007274 A KR 1020147007274A KR 20147007274 A KR20147007274 A KR 20147007274A KR 20140064887 A KR20140064887 A KR 20140064887A
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South Korea
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storage container
micro needle
patch
microneedle
convex portion
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KR1020147007274A
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Korean (ko)
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KR101990654B1 (en
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잉-슈 취안
후미오 가미야마
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코스메드 파마소티컬 씨오 쩜 엘티디
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Priority claimed from JP2011225328A external-priority patent/JP5687170B2/en
Application filed by 코스메드 파마소티컬 씨오 쩜 엘티디 filed Critical 코스메드 파마소티컬 씨오 쩜 엘티디
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

There is provided a micro needle patch storage container for holding the micro needle patches sanitarily without damaging the effect during use after manufacture of the micro needle patches. The storage container has a bottom surface concave to the center in the center, a side connecting the bottom surface and the peripheral portion, and a bottom surface convexity protruding from the bottom surface, and the release sheet portion of the flexible micro needle patch is held by the bottom surface convex portion . The storage container can be used with a lid having a concave portion for pressing a microneedle patch held on the bottom convex portion at a position corresponding to a part of the bottom convex portion. In order to hold and retain the micro needle patch in an aseptic state, it is preferable to store it in a bag formed of a thin paper or an antibacterial film sheet.

Description

Micro needle patch storage container {MICRONEEDLE PATCH CONTAINER}

The present invention relates to a storage container for storing a micro needle patch.

Liquid substances, ointments, cream preparations, tape preparations, patch preparations, puff preparations and the like, which contain a pharmaceutical active ingredient, have been used for imparting a modifying effect or a functional effect to the skin surface layer or the skin horny layer. They are intended to exert their effects by infiltrating the medicinal ingredient into the skin by applying or sticking to the surface of the skin. However, when the composition is applied to the skin, the active ingredient is easily lost or eliminated due to sweating action of the skin or external contact with the skin. In addition, the skin has a barrier function of preventing foreign matter from entering the body, and it is difficult to absorb the medicinal ingredient into the skin just by applying or attaching the medicinal ingredient to the skin.

In recent years, these problems have been solved, and micro needle has been developed as a method for surely supplying a medicinally effective ingredient into the skin, and research is being conducted. The micro needle is a minute needle having a length of less than 1 mm (Patent Document 1). When the microneedles are produced by a substance which easily dissolves and disappears in vivo, the entrained microneedles dissolve in the skin, are absorbed and disappear (Patent Document 2). Therefore, if the micro-needle is preliminarily contained with the active ingredient, the active ingredient can be supplied to a specific site in the skin. If a plurality of such micro-needles are arranged on a substrate, the microneedle array becomes a microneedle array, and the amount of transmission can be increased in proportion to the number of needles, so that there can be a great expectation for practical use (Patent Document 2-4, Non-Patent Document 1). In the micro needle array, an adhesive tape for attaching the micro needle array to the skin is added to the micro needle array to make it easy to use.

Since the length of the micro needle is generally shorter than 1 mm and the diameter is about 0.1 mm, it does not feel pain at the time of insertion and there is no bleeding. The entry point is quickly closed, leaving no trace. As a result, it has been recognized that the microneedle is an excellent method of delivering a specific active ingredient to a specific site of the skin. In addition to medical applications such as delivery of a vaccine, microneedles are attracting attention as a cosmetic product for delivering effective ingredients of skin such as hyaluronic acid to the skin surface and for suppressing dots and bruises.

The initial microneedles had about 100 microneedles on a rigid substrate of about 1 cm2. Recently, however, there has been a desire to improve a large part of the face at one time, and a microneedle array having microneedles thereon has been developed so as to soften the substrate and fit on the face rather than on the plane.

In order to supply micro-needle arrays to consumers on the market, proper containers are needed. Since the microneedle array has a needle part and it is necessary to protect the needle part during transportation, sale, and preservation, it is possible to use a conventionally widely used container such as a tape or the like (patent documents 5 and 6) There is no. Further, it is not possible to use a rigid substrate container (Patent Document 7-9) in a microneedle array having a soft substrate.

Japanese Patent Publication No. 2002-517300 Japanese Patent Application Laid-Open No. 2003-238347 Japanese Patent Application Laid-Open No. 2006-346126 Japanese Patent Application Laid-Open No. 2008-284318 Japanese Patent Laid-Open No. 2006-056543 Japanese Patent Publication No. 2008-518042 Japanese Utility Model Registration No. 3152532 Japanese Patent Application Laid-Open No. 2010-75485 Japanese Patent Application Laid-Open No. 2010-75486

Kwon Young-suk, Kamiyama Fumio, "A Study on Micro Needle Productization", Pharmaceutical Society of Japan, Japan Pharmaceutical Society, April 2009, Vol. 69, No. 4, p.272-276

Since the micro needle patches are used to patch the skin to deliver medicinally active ingredients, they need to be held hygienically and without damaging its efficacy for a period of time after its manufacture through distribution and use. SUMMARY OF THE INVENTION It is an object of the present invention to provide a micro needle patch retractor suitable for holding a micro needle patch in which an adhesive tape is attached to a flexible micro needle array and a release sheet is attached to the adhesive surface, It is in providing the courage.

The microneedle patch storage container according to the present invention which has been made in order to solve the above problems is characterized in that it has one or a plurality of bottom surfaces concave than the peripheral part, a side connecting the bottom surface and the peripheral part, and a bottom surface convex part protruded from the bottom surface, And the release sheet portion of the micro needle patch is held by the bottom convex portion.

One micro needle patch storage container can accommodate as many micro needle patches as the number of the bottom side. Normally, one micro needle patch storage container holds one micro needle patch. However, for example, in the case of a micro needle patch pasted under the eyes, since patches are usually placed under the eyes of right and left eyes, it is preferable for the trade to store two sets of patches.

It is also possible to hold two or more micro needle arrays in one micro needle patch. In this case, two or more microneedle arrays can be accommodated in one container.

The microneedle patch storage container according to the present invention has a concave portion for pressing a micro needle patch held on the bottom convex portion at a position corresponding to a part of the bottom convex portion, It is preferable that the lid having no recess is provided. Although the release sheet portion of the micro needle patch is held on the bottom convex portion, if the concave portion of the lid is formed so as to entirely press it, the micro needle patch is brought into close contact with the lid by the action of the static electricity. If the micro needle patch is attracted to the lid by the static electricity, the micro needle patch suddenly protrudes when the lid is detached, and it is also difficult for the micro needle patch to be attracted to the storage container to be taken out. When the pressing by the concave portion of the lid is partially performed, the influence of the static electricity is weakened and the handling becomes easy, which is preferable. It is preferable that the area of the bottom convex portion is larger than the area of the concave portion of the lid in order to prevent the micro needle patch from being adsorbed on the lid by reducing the influence of the static electricity.

When the bottom convex portion has a substantially rectangular shape, it is preferable that the release sheet of the micro needle can be pressed and held easily. It is also possible to divide the rectangular shape into several pieces so that the plurality of convex portions hold the four sides of the release sheet.

The micro needle patch storage container is preferably capable of stacking a plurality of the containers by fitting them together. For this purpose, it is preferable that the micro needle patch stored in another micro needle patch storage container is partially pressed by the outside of the bottom surface of the micro needle patch.

In order to enhance the cosmetic effect of attaching the micro needle patch to the face and replenishing the hyaluronic acid and the active ingredient to remove the wrinkles, it is usually necessary to apply the patch while wearing it over several days. Therefore, it is preferable for a transaction to be able to package a number of sheets necessary for a series of uses.

It is preferable that the microneedle array is provided with a notch and an ear at the corresponding positions of the storage container and the lid of the storage container so that the lid can be easily separated from the storage container at the time of use. The micro needle patch storage container needs to be sealed from the time of manufacture until immediately before use, but it is necessary to take out the micro needle patch storage container easily when using it.

It is preferable to form an expanded portion on the bottom surface of the micro needle patch storage container so that the micro needle patch can be picked up and taken out easily. This is to make it easy to pick up the micro needle patch even when it is closely attached to the storage container by static electricity.

The microneedle patch storage container according to the present invention is preferably provided with an antistatic treatment on its surface. When the storage container is charged, the micro needle patch is sucked to the storage container and becomes difficult to handle.

The present microneedle patch storage container can hold the microneedles in a hermetically sealed state, but can not necessarily hold them in an aseptic state. In order to hold the micro needles aseptically, it is preferable to sterilize the containers and the micro needles, and then store the containers in a pocket formed by a thin paper or an antibacterial film sheet to seal them. As the antibacterial film sheet, a plastic sheet or an aluminum sheet can be suitably used. The aluminum sheet is particularly preferable because it has high airtightness.

In the case of a so-called adhesive medicine in which the adhesive agent, that is, the active agent ingredient and the adhesive are mixed and spread on a resin film, a release sheet is usually placed on the active ingredient, and the release agent sheet is peeled off before attaching to the skin, It is customary to affix it. In this case, although it is preferable to be clean because it is stuck on the stratum corneum of the skin, sterility is not required because of the barrier effect of the stratum corneum.

In this respect, the necessary conditions for the micro needle patch storage container are more stringent than those required for the patch storage container. Micro-needles must be hygienically preserved as they enter the skin. Further, since the needle can not be inserted into the skin unless it is sharp, it is not possible to strike a hard object which can damage the tip of the needle. Further, since the needle is inserted into the skin, it is not allowed to attach to the body such as a pressure-sensitive adhesive so that it is unknown whether it is safe or not. That is, the microneedles must be retained and retained only in the portion of the release sheet in a state of being in a sterilized state and not in contact with any part of the container. As a result, the micro needle patch storage container necessarily differs structurally from the patch storage container, and can not be designed from the patch storage container.

Further, when the micro needle array is flexible, a method of preserving a rigid micro needle array can not be used as it is. Stiff and flexible are due to different holding methods.

The material of the micro needle patch storage container is not particularly limited, but a resin which is easy to perform injection molding or press working is preferable. Particularly, it is preferable to be transparent or semitransparent because the situation of contents can be seen from the outside. In addition, it is preferable that the permeability of air or water vapor is small so that the micro needle patch can be stably protected over a long period of time. Specifically, polyethylene terephthalate (PET), polypropylene (PP), and polyethylene (PE) are preferable, but PET is particularly preferable because it is less deteriorated or exfoliated by γ-ray or electron beam irradiation sterilization.

According to the microneedle patch storage container of the present invention, the microneedle patch is held by the release sheet portion, and the microneedle portion is not in contact with any portion of the container. Even if the micro needle patch is a flexible sheet, it can be held hygienically until it is opened.

When the storage container is used, the micro needle patch can be easily taken out when necessary. Further, the storage containers can be stacked on each other, so that several micro needle patches necessary for a series of use can be easily packed.

The microneedle patch storage container of the present invention is designed to avoid the influence of static electricity. If there is an influence of the static electricity, the micro needle patch is sucked on the cover and suddenly pops out when the lid is detached, or it becomes difficult to be picked up by the storage container.

1 is a view showing a microneedle patch used in Example 1-3.
2 is a view of a first embodiment of a micro needle patch storage container.
3 is a view of the cover of the microneedle patch storage container of the first embodiment.
4 is a view of a second embodiment of the micro needle patch storage container.
5 is a view of the cover of the microneedle patch storage container of the second embodiment.
6 is a view of a third embodiment of the micro needle patch storage container.
7 is a view of a fourth embodiment of the micro needle patch storage container.
8 is another view of a fourth embodiment of the micro needle patch storage container.
9 is a view of the microneedle array used in the fifth embodiment.
10 is a view of a fifth embodiment of the micro needle patch storage container.

Hereinafter, embodiments of the present invention will be described on the basis of embodiments. The present embodiment is designed to accommodate a micro needle patch designed on the assumption of attaching under the eyes, but if the micro needle array patch of another shape is designed, it may be appropriately changed in design accordingly, and the present invention is not limited to the shape of the embodiment .

The microneedle patch 10 used in this embodiment is shown in Fig. As shown in Fig. 1, the microneedle array 11 has a planar shape in which the bottom of the cross section of the convex portion of the central portion is recessed, and has a lateral width of about 35 mm and a longitudinal width of about 15 mm. The cross-section of the convex portion of the central portion means a convex curve portion as in the outer shape of the microneedle array 11 shown in Fig. 1, and a convex curve portion or a straight portion with a smaller curvature than the convex curve portion , And both ends are connected to each other. This is a shape designed on the assumption of attaching under the eyes. The microneedles are provided on a flexible sheet and can be deformed to conform to the irregularities of the face as a whole of the microneedle array.

The size of the microneedles is not limited, but is about 50 to 500 / cm2 of needle having a length of 30 to 1000 mu m. Its main ingredient is hyaluronic acid, but it contains ingredients effective for skin wrinkles and revitalization.

The pressure sensitive adhesive sheet 12 having a shape approximately equal to that of the micro needle array portion and having a width of 2 to 10 mm wide is adhered to the surface opposite to the surface of the microneedle array. The adhesive surface is in the same direction as the array surface. On the microneedle array side, a substantially rectangular release sheet 13 (70 占 45 mm) excluding the microneedle array portion is pasted so as to cover the adhesive surface.

The bottom portion of the adhesive sheet 12 is narrowed in order to attach the micro-needle array 11 as close as possible to the eye.

When the microneedle patch is used, since a cutting line is formed at the center of the release sheet 13, both ends of the release sheet are held, and when the release sheet is brought into contact with the application site ). Thereafter, the microneedle is inserted into the keratinous tissue by gently tapping the surface of the microneedle array 11. Since the portion of the skin that feels pain is said to be about 1 mm inward from the surface of the skin, it hardly feels pain due to this ingestion.

(Example 1)

An example of a micro needle patch storage container suitable for the micro needle patch described above is shown in Fig. The material is polyethylene terephthalate (PET).

The micro needle patch storage container 30 may be a storage container which is closed by covering the cover. An example of the lid 20 is shown in Fig. The surfaces of the micro needle patch storage container 30 and the lid 20 are subjected to antistatic treatment.

The microneedle patch storage container 30 of this embodiment has a substantially rectangular shape with an outer dimension of about 88 mm 63 mm and a substantially rectangular bottom face having a depth of about 5 mm and a size of about 72 mm 49 mm 32). The bottom surface 32 is planar and has a substantially uniform depth and is connected to the peripheral portion 31 by a side surface 33. A substantially rectangular bottom protrusion 34 is formed from the bottom surface 32. The height of the bottom convex portion 34 is about 2 mm, and the upper portion is rounded. Four side convex portions 35 are formed on the inner side of the side surface 33 and have the same height as the bottom convex portion 34. [

The storage container 30 has such a size that the micro needle patch 10 is tightly packed therein. The micro needle patch 10 is tightly accommodated in the storage container with the surface of the micro needle 11 facing downward. The area 38 indicated by double double-dashed lines in Fig. 2 indicates a portion where the micro needle portion 11 is present when the micro needle patch 10 is housed in the storage container 30, The structure of the storage container 30 is not shown. At this time, the micro needle patch 10 is supported by the bottom convex portion 34 and the side convex portion 35, so that the microneedle portion 11 is not in contact with any part of the storage container 30.

In the drawing of the concave portion of the storage container, the upper right and lower left inflated portions are formed to facilitate picking up and taking out the micro needle patch when taking out the micro needle patch from the storage container. Although the micro needle patch is tightly inserted into the storage container, it can be easily picked up by inserting a finger into the expanded portion.

The lid 20 for the storage container described above is a rectangle which is almost the same size as the storage container 30. The lid 20 has a concave portion 22 which is concave from the peripheral portion 21 and matches the concave portion 32 of the accommodating container 30. The concave portion 22 and the bottom convex portion 34 and the side convex portion 35 of the accommodating container are held by the microneedle patch between them when the lid 20 and the storage container 30 are engaged with each other do.

There is an ear 26 on the outside of the lid 30 and a notch 36 at a corresponding position outside the receptacle 30. These are formed to facilitate separation of the lid from the storage container.

The microneedle patch storage container 30 of the present embodiment does not press the microneedle patch completely by the bottom convex portion 34 and the concave portion 22 of the lid. If the micro needle patch is completely pressed, the lid is attracted to the lid 20 suddenly when the lid is detached due to static electricity, or is suddenly ejected to the storage container 30 and becomes difficult to be taken out.

As shown in Figs. 2 and 3, the position of the bottom surface convex portion 34 of the storage container and the position of the concave portion 22 of the lid are shifted from each other, so that the micro needle patch is not completely pressed. In the case of the present embodiment, the concave portion 22 of the lid is disposed from the side convex portion 35 toward the rim of the bottom convex portion 34.

The concave portion 22 of the lid is formed on the upper and lower sides in the figure but not on the left and right sides. That is, the micro needle patches are not pressed from above in the right and left portions of the bottom surface convex portion 34 in Fig. The micro needle patch can be easily taken out by avoiding the influence of the static electricity.

The microneedle patch storage container 30 of the present embodiment may be replaced with another storage container by covering the other storage container after the microneedle patch is received without the cover.

The microneedle patch storage container containing the microneedle patch may be housed in a bag made of the microfiltrated aluminum film sheet after sterilization without holding the cover, and may be hermetically held.

The microneedle patch storage container containing the microneedle patch may be sealed by putting a sterilized paper laminated with a heat sealable film or polyethylene without covering and by fusing the film with the periphery of the storage container by heat sealing.

(Example 2)

Another example of the micro needle patch storage container is shown in Fig. The micro needle patch storage container 50 may be a storage container in which a cover is closed to close it. An example of the lid 40 is shown in Fig. The material of the micro needle patch storage container 50 and the lid 40 is polyethylene terephthalate (PET), and their surfaces are subjected to antistatic treatment.

The microneedle patch storage container 50 of the present embodiment has a substantially rectangular shape with an outer dimension of about 88 mm 63 mm and a substantially rectangular bottom face having a depth of about 5 mm and a size of about 72 mm 49 mm recessed from the peripheral portion 51 52). The bottom surface 52 is planar and has a substantially uniform depth and is connected to the peripheral portion 51 by a side surface 53. And the bottom surface convex portions 54 are formed from the bottom surface 52 thereof. Of these, each of the upper and lower five of the drawings is on a straight line. The upper portion of the bottom convex portion 54 is rounded, and the height is all the same and is about 2.5 mm.

Six side convex portions 55 are formed on the inner side of the side surface 53, and the micro needle patches 10 are sufficiently inserted into the side convex portions 55. When the microneedle patch is placed in the storage container, the release sheet 13 is tightly fitted to the six side projections 55 and does not move back and forth and left and right. The bottom surface convex portion 54 supports the release sheet 13, And is not in contact with the needle array 11.

A region 58 indicated by double double-dashed lines in Fig. 4 indicates a portion where the micro needle portion 11 is present when the micro needle patch 10 is housed in the storage container 30, And does not show the structure of the container 50. [ At this time, the microneedle patch 10 is supported by the bottom convex portion 54 and the side convex portion 55, so that the microneedle portion 11 is not in contact with any part of the storage container 50.

The lid 40 of the storage container of the present embodiment is a rectangle approximately the same size as the storage container 50. [ The lid 40 has a concave portion 42 that is concave to the peripheral portion 41 and matches with the concave portion of the storage container. The concave portion 42 holds the micro needle patch 10 from above and below as a whole in response to the bottom convex portion 54 of the storage container when the lid 40 and the storage container 50 are engaged with each other.

There is an ear 46 at the outside of the lid 40 and a notch 56 at the corresponding position outside the housing 50. [ These are formed to facilitate separation of the lid from the storage container.

Unlike the case of the first embodiment, the micro needle patch storage container of the present embodiment is only in contact with the side projections so that the micro needle patch storage container 50 and the lid 40 are in close contact with each other. That is, the micro needle patch has a slight margin and is sandwiched between the bottom convex portion of the storage container and the concave portion of the lid, and is not strongly pressed.

The concave portion of the lid is formed on the upper and lower sides of the figure but not on the left and right sides. The micro needle patches extend over the bottom protrusions on the right and left sides in Fig. 4, but are not sandwiched from above.

(Example 3)

An example of a micro needle patch storage container capable of accommodating two micro needle patches is shown in Fig. The micro needle patch storage container 60 may be a storage container in which a cover is closed and closed. The material of the micro needle patch storage container 60 is polyethylene terephthalate (PET), and its surface is subjected to antistatic treatment.

The microneedle patch storage container 60 is provided with two bottom portions at the peripheral portion, and the configuration of each bottom portion is the same as that of the storage container 50, and therefore its detailed description is omitted. The cover of the storage container 60 is assumed to be easily estimated based on Fig. 6 and the lid 40, and therefore, illustration thereof is omitted. The micro needle patch is retained in the same manner as in the second embodiment.

(Example 4)

An example of a micro needle patch storage container capable of accommodating a micro needle patch holding two micro needle arrays is shown in Figs. 7 and 8. Fig. This micro needle patch holds two micro needle arrays 68 on one sheet of release sheet. Further, in the case of this embodiment, the adhesive tape 69 is attached to only a part of the microneedle array.

By doing so, two micro needle arrays can be accommodated more easily than in the case of Fig.

7 shows a microneedle patch storage container 60 holding two elongated microneedle arrays. The external dimensions are slightly larger than those in Fig. And a bottom surface 62 having a depth of about 5 mm which is concave than the peripheral portion 61 at the center. And a substantially rectangular bottom convex portion 64 is formed from the bottom. The bottom convex portion 64 may be made relatively larger than the bottom convex portion 34 in Fig. 2 for accommodating two microneedle arrays. In addition, lateral bottom convex portions may be additionally provided between the two micro needle arrays in the central portion. Since the configuration of the other parts is the same as that of FIG. 2, the description is omitted.

In Fig. 7, the broken line indicates an example of the micro needle array 68 and the adhesive tape 69. These are examples when the microneedle patch is housed in a storage container and do not show the structure of the storage container.

8 shows a micro needle patch storage container 70 holding two thick micro needle arrays. The external dimensions are slightly larger than those in Fig. And a substantially rectangular bottom surface 72 having a depth of about 5 mm which is concave from the peripheral portion 71 at the center. The bottom surface 72 is planar and has a substantially uniform depth and is connected to the periphery 71 by a side surface. And the bottom surface convex portions 74 are formed from the bottom surface 72. Of these, each of the upper and lower five of the drawings is on a straight line. The upper surface of the bottom convex portion 74 is round, and the height is all the same and is about 2.5 mm. 4, the bottom protrusion 74 of Fig. 8 extends relative to the entire container relative to the bottom protrusion 54 of Fig. 4 in order to hold the two micro needle arrays. This is to hold two microneedle arrays in a narrow space.

8 are examples of the microneedle array 68 and the adhesive tape 69. In Fig. These are examples when the microneedle patch is housed in a storage container and do not show the structure of the storage container.

(Example 5)

Four micro needle arrays are housed in one micro needle patch storage container.

Fig. 9 shows a micro needle array in which a pressure sensitive adhesive sheet is provided only on the periphery of the micro needle array. It is preferable that the adhesive sheet is provided on the side of the microneedle array on which the micronee needle is not provided and the adhesive sheet is not present on the back surface of the microneedle.

A microneedle patch holding four such microneedle arrays on one release sheet is preferable when four microneedle patches are used at a time.

The microneedle patch storage container 80 of the fifth embodiment can be the same as that of the fourth embodiment as shown in Fig. 10, but it is easy to use a larger overall size in order to store four microneedle arrays. And a bottom surface 82 having a depth of about 5 mm which is recessed from the peripheral portion 81 at the center. And a substantially rectangular bottom convex portion 84 is formed from the bottom face. It is preferable that the bottom convex portion 84 is relatively larger than the bottom convex portion 34 in Fig. 2 in order to accommodate four microneedle arrays. Further, cross-shaped or columnar bottom convex portions may be additionally provided between the four micro-needle arrays in the central portion. The other parts are the same as those in Fig. 2, and a description thereof will be omitted.

In Fig. 10, the four micro needle arrays shown in Fig. 9 are indicated by broken lines. These are examples when the microneedle patch is housed in a storage container and do not show the structure of the storage container.

10: Micro needle patch
11: Micro needle array
12: Pressure sensitive adhesive sheet
13: release sheet
20, 40: Micro needle patch storage container cover
21, 41: peripheral portion of the cover
22, 42: concave portion of the cover
26, 46: an ear for releasing the engagement between the container and the lid
30, 50: Micro needle patch storage container
31, 52, 61, 71, 81: peripheral portion of the storage container
32, 52, 62, 72, 82: a concave bottom surface
34, 54, 64, 74, 84: bottom convex portions formed in concave portions of the bottom surface
35, 55: side convex portion
38, 58: area
60, 70: Micro needle patch storage container capable of storing two micro needle arrays
68: Micro needle array
69: Adhesive tape
80: Micro needle patch storage container capable of storing four micro needle arrays
87: Micro needle array
88: Micro Needle Patch

Claims (11)

And a lower surface convex portion protruding from the bottom surface, wherein the release sheet portion of the flexible micro needle patch is provided on the bottom surface convex portion of each of the bottom surfaces And the micro needle patch storage container. 2. The stapler according to claim 1, further comprising a concave portion for pressing the micro needle patch held on the bottom convex portion at a position corresponding to a portion of the bottom convex portion, wherein the concave portion is provided at a position corresponding to another portion of the bottom convex portion, And a micro needle patch storage container. The microneedle patch storage container according to claim 2, wherein the area of the bottom convex portion of the storage container is larger than the area of the lid recess portion. The micro needle patch storage container according to any one of claims 1 to 3, wherein the bottom convex portion has a rectangular shape. The micro needle patch storage container according to any one of claims 1 to 3, wherein the bottom convex portion is arranged so that a plurality of convex portions support four sides of the release sheet of the microneedles. The microneedle patch containment container according to any one of claims 1 to 5, which houses a microneedle patch holding two or more microneedle arrays. The micro needle patch storage container according to claim 2, wherein the micro needle patch storage compartments can be stacked on each other by partially pressing the release sheet of the micro needle patch at the bottom of another micro needle patch storage compartment instead of the cover. . The microneedle patch storage container according to claim 2, characterized in that the microneedle patch storage container and the cover are provided with a cut-in and an ear at corresponding positions. The microneedle patch storage container according to any one of claims 1 to 7, wherein the bottom surface is formed with an expanded portion for easy picking up and taking out of the microneedle patch. The microneedle patch storage container according to any one of claims 1 to 9, characterized in that an antistatic treatment is added to the surface. 11. The microneedle patch storage container according to any one of claims 1 to 10, characterized in that the periphery of the storage container is fused and sealed by a heat seal with a heat-sealable film or a film laminated with a film.

KR1020147007274A 2011-09-22 2012-09-20 Microneedle patch container KR101990654B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2011-225328 2011-09-22
JP2011225328A JP5687170B2 (en) 2011-03-30 2011-09-22 Microneedle patch storage container
PCT/JP2012/074048 WO2013042723A1 (en) 2011-03-30 2012-09-20 Microneedle patch container

Publications (2)

Publication Number Publication Date
KR20140064887A true KR20140064887A (en) 2014-05-28
KR101990654B1 KR101990654B1 (en) 2019-06-18

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WO2017061701A1 (en) * 2015-10-08 2017-04-13 주식회사 라파스 Microneedle patch packaging case

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JP2003238347A (en) 2002-02-18 2003-08-27 Nano Device & System Research Inc Functional micropile and method for producing the same
JP2006056543A (en) 2004-08-18 2006-03-02 Kanae Technos:Kk Gel sheet package for pack
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JP2008284318A (en) 2007-05-15 2008-11-27 Kosumedei Seiyaku Kk Microneedle for dosing, including living body origin matter
JP3152532U (en) * 2009-04-22 2009-08-06 コスメディ製薬株式会社 Microneedle patch storage case
JP2010075485A (en) 2008-09-26 2010-04-08 Toppan Printing Co Ltd Microneedle holding vessel
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JPS6063344U (en) * 1983-10-06 1985-05-04 丸正金属箔工業株式会社 Container for poultice
JP3152532B2 (en) 1993-02-04 2001-04-03 塩野義製薬株式会社 Anti-influenza A active cuparan sesquiterpene compound
JPH10511330A (en) * 1994-12-21 1998-11-04 エシカル・ファーマシューティカル・(ユー.ケイ.)リミテッド Container to put the patch
JP2002517300A (en) 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション Microneedle devices and methods of manufacture and uses thereof
JP2003238347A (en) 2002-02-18 2003-08-27 Nano Device & System Research Inc Functional micropile and method for producing the same
JP2006056543A (en) 2004-08-18 2006-03-02 Kanae Technos:Kk Gel sheet package for pack
JP2008518042A (en) 2004-10-07 2008-05-29 アクセス ビジネス グループ インターナショナル エルエルシー A composition comprising a rosemary (Rosmarinusofficinalis) plant extract, an Alpinia plant extract, and a DNA repair enzyme.
JP2006346126A (en) 2005-06-15 2006-12-28 Nabtesco Corp Dermal needle
JP2008284318A (en) 2007-05-15 2008-11-27 Kosumedei Seiyaku Kk Microneedle for dosing, including living body origin matter
JP2010075485A (en) 2008-09-26 2010-04-08 Toppan Printing Co Ltd Microneedle holding vessel
JP2010075486A (en) 2008-09-26 2010-04-08 Toppan Printing Co Ltd Microneedle holding vessel
JP3152532U (en) * 2009-04-22 2009-08-06 コスメディ製薬株式会社 Microneedle patch storage case

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Publication number Priority date Publication date Assignee Title
WO2017061701A1 (en) * 2015-10-08 2017-04-13 주식회사 라파스 Microneedle patch packaging case

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