KR20130135436A - Device for trapping air bubble of the fluid warming and rapid infusion system - Google Patents

Abstract

The present invention relates to an air bubble removal apparatus of a fluid heating and rapid injection device which comprises the following: a housing for inflowing and discharging fluid; first and second chambers connected to the housing; a first flux reduction shield changing the flow of the fluid inside the first chamber to the opposite direction of the gravity; a second flux reduction shield reducing the flux of the fluid flowing inside the second chamber; and a bubble removal chamber attached to the housing and connected to the first chamber. The fluid or blood with microbubbles flows through a conduit by the first and second chambers and the first and second flux reduction shields, and the microbubbles are separated from the fluid or the blood by the rapidly reduced flux and gravity and transferred and accumulated in the bubble removal chamber.

Description

Device for trapping air bubble of the fluid warming and rapid infusion system

The present invention relates to a defoamer of warming and rapid injector, and more particularly, to a defoamer of warming and rapid injector for removing bubbles generated when rapid injection of warming sap or blood.

In general, the fluid warming and rapid infusion devices, which have recently been widely used in clinical practice, are sufficiently heated in the patient's body in a low blood condition caused by massive bleeding during surgery, or in a shock condition commonly occurring in an emergency room or an intensive care unit. Rapid infusion is a device used to prevent and treat hypothermia and hypovolemia and its complications.

However, the sap warming and rapid injection device generates micro bubbles during warming, and the generated micro bubbles are initially introduced into the catheter and stagnated in the bent portion of the conduit by gravity, but the continuously generated micro bubbles gradually accumulate. Eventually, it can enter the body and cause fatal air embolism.

In addition, the use of a rapid infusion device is essential in liver transplantation for patients with end-stage liver disease, and in these patients, arteriovenous shunt due to intrapulmonary vasodilatation due to hepatic pulmonary syndrome is relatively common. It is known to occur in 8-24% of subjects. In these patients, even if a small amount of air enters through the central vein during surgery, since the air bubbles spread directly to the systemic arterial blood vessel including the cerebrovascular vessel, it is very fatal and requires careful attention.

Therefore, some of these expensive injection devices are equipped with a bubble sensor applied with an ultrasonic device (ultrasound device), etc. in the device circuit to detect the generation of bubbles of a certain size generated during heating and to stop the fluid / blood flow to stop the bubble Although air embolism can be prevented due to injection, most rapid injection devices often do not have a bubble detection sensor, and even if a bubble detection sensor is provided, the occurrence of microbubbles that are inevitably accompanied by heating cannot be detected. In most cases, if the microbubble is not immediately recognized, it can be dangerous to the safety of the patient because it is irresponsible for the development of air embolism.

A representative example of a bubble (gas) removal device for preventing the occurrence of such complications, such as air embolism is disclosed in the following Document 1 (hereinafter referred to as 'prior art'), the prior art bubble removal device to remove the bubble Hazardous liquids are designed to penetrate the hydrophobic membrane, which inevitably leads to lower flow rates in the conduit, making them difficult to apply to rapid injection devices.

Specifically, the bubble removing device of the prior art has a low bubble removal efficiency when the fluid flow rate is 100ml / min or less, and is not effective to remove bubbles from the fluid when the fluid flow rate is 350ml / min or more, so the fluid velocity is in a specific range It is difficult to apply if the equipment is not kept constant within.

That is, the defoaming device of the prior art that causes the flow rate to be lowered is applicable to a low-speed flow rate device that maintains a flow rate of about 100 ml per hour, such as Continuous Renal Replacement Therapy (CRRT), but as in the sap heating and rapid injection device. High speed flow equipment capable of flow rates up to 750 ml / min is not applicable because of increased resistance and reduced flow rates.

In addition, when the blood product is administered together, the filter method has a limit in filtration rate and may cause problems such as blood coagulation in the filter.

Therefore, there is a demand for the development of an improved fluid heating device and a bubble removing device of a rapid injector capable of removing micro bubbles.

[Document 1] Korean Patent Publication No. 2011-0009655 (2011.01.28)

The present invention has been made to solve the above-mentioned conventional problems, an object of the present invention is to provide a bubble removing device of the fluid warming and rapid injector that can remove the micro bubbles without causing a decrease in the flow rate in the conduit have.

In order to achieve the above object, the fluid degassing apparatus of the fluid heating and rapid injector of the present invention, the fluid inlet and outlet housing; First and second chambers formed in communication with the housing; A first flow rate reducing shield for converting the flow of the fluid in the first chamber in a direction opposite to gravity; A secondary flow rate reduction shield for reducing the flow rate of the fluid flowing through the second chamber; And a bubble removing chamber attached to the housing and in communication with the first chamber.

The apparatus may further include an inlet formed in the first chamber side of the housing and a discharge port formed in the second chamber side of the housing, wherein the discharge side of the inlet is formed to face the primary flow rate reducing shield, and the inlet side of the discharge port is the second outlet. It is characterized in that it is formed to face the vehicle flow rate reducing shield.

The apparatus may further include a boundary surface that crosses the housing and partitions the first and second chambers so that a through hole is formed in the center thereof.

In addition, the boundary surface is characterized in that it is formed to be inclined upward toward the center where the through hole is formed from the border in contact with the housing.

In addition, the housing is characterized in that formed of a transparent material.

In addition, the first and second flow rate reducing shield is characterized in that formed in the '' 'cross-section.

In addition, the discharge side of the bubble removing chamber is characterized in that the rubber packing further opened by the pressure is further provided.

In addition, the inlet and the outlet is characterized in that it is formed to have the same inner diameter.

According to the degassing apparatus of the sap heating and rapid injector according to the present invention, the sap and blood containing the microbubble introduced through the conduit by the first, second chamber and the first and second flow rate reducing shield is rapidly reduced flow rate and The microbubbles are separated from the sap and blood by gravity, and are moved and accumulated in the bubble removing chamber to remove the microbubbles.

That is, it prevents the microbubbles outflow into the conduit.

In addition, the flow rate of the fluid and blood discharged from the bubble removing device of the present invention by the same inlet and discharge port having the same Bernoulli's principle applied is the same as the flow rate before the flow into the bubble removing device, the flow rate in the conduit before and after the bubble removing device Does not cause degradation.

Accordingly, since the flow rate in the conduit before and after the bubble removing device does not cause a drop in the flow rate, the fluid flow rate varies from the minimum 5 ml / min to the maximum 750 ml / min, depending on the clinical situation. Application is suitable.

In addition, it is possible to visually check the generation and removal of bubbles by the housing formed of a transparent PVC material.

After all, according to the bubble removing device of the sap heating and rapid injector of the present invention, the micro-bubble generated when applied to the sap heating and rapid injection device essential for anesthesia management of serious patients such as liver transplant surgery, open heart surgery that is expected to mass bleeding The elimination of airborne embolism can be prevented, greatly increasing patient safety.

In addition, in view of the principles of the present invention, even in the absence of sap warming and rapid infusion devices, inflow of a small amount of air is tolerated, as in pediatric or adult patients suspected of right-left shunt in the heart. In the absence of such circumstances, it is expected that the present invention may be extended to the lowermost side of the general route of administration of administration, and the clinical needs of such applications will be very high.

1 is a perspective view showing a bubble removing apparatus according to the present invention.
2 is a cross-sectional view of Fig.
3 is a view showing a fluid path of the bubble removing apparatus according to the present invention.
4 is a plan sectional view of the housing of FIG.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a perspective view showing a bubble removing apparatus according to the present invention, Figure 2 is a cross-sectional view of Figure 1, Figure 3 is a view showing a fluid path of the bubble removing apparatus according to the present invention, Figure 4 is A plan sectional view showing the housing.

As shown in Figures 1 to 4, the degassing apparatus (A) of the sap heating and rapid injector according to the present invention, the housing 100 through which fluids, such as fluid and blood flows in and out, and the housing 100 ), The first and second chambers 200 and 300 formed to communicate with each other, a first flow rate reducing shield 400 for converting the flow of the fluid in the first chamber 200 in a direction against gravity, and the second chamber. Consists of a secondary flow rate reduction shield 500 for converting the flow of the fluid in the direction opposite to gravity and a bubble removing chamber 600 attached to the housing 100 and in communication with the first chamber 200 do.

First, the housing 100 is formed in a cylindrical body as shown in FIG. 1 and used in an upright state. The flow of fluid is moved from the upper part of the housing 100 to the lower part.

In addition, the first and second flow rate reduction shields 400 and 500 are accommodated inside the housing 100, and the inner circumferential surfaces of the first and second flow rate reduction shields 400 and 500 and the housing 100 are provided by separate connection means. The first and second flow rate reducing shields 400 and 500 are fixed to the space portions of the first and second chambers 200 and 300.

For example, when the housing 100 is viewed in plan, the outer circumferential surface of the first and second flow rate reducing shields 400 and 500 and the inner circumferential surface of the housing 100 are four or more connectors 140 as shown in FIG. 4. The arrangement is made radially and fixed. Of course, it is desirable to be connected so as not to interfere with the clouding of the fluid.

In addition, the inlet 110 formed at the side of the first chamber 200 of the housing 100 and the outlet 120 formed at the side of the second chamber 300 of the housing 100 are further included. In this case, the discharge side of the inlet 110 is formed to face the primary flow rate reduction shield 400 and the inlet side of the discharge port 120 is formed to face the secondary flow rate reduction shield 500.

At this time, the inlet 110 is formed with a first connector 111 is connected to the discharge side of the sap heating and rapid injector, the discharge port 120 is formed with a second connector 121 is connected to the catheter (catheter) do.

The boundary surface 130 further includes a boundary surface 130 that crosses the housing 100 so as to partition the first and second chambers 200 and 300, and a through hole 131 is formed in the center thereof, and the boundary surface 130 includes a housing ( 100 is formed to be inclined upwardly from the edge contacting the through hole 130 is formed to play a role of reducing the flow velocity of the fluid once again.

The first and second flow rate reducing shields 400 and 500 are formed in a cross-section of the letter 'C' to reduce the flow rate of the fluid.

Specifically, the first flow rate reducing shield 400 is arranged to open the upper portion, the second flow rate reducing shield 500 is arranged to open the lower portion.

Accordingly, as shown in FIG. 3, the fluid passes through the first chamber 200, the first flow rate reducing shield 400, the boundary surface 130, the second chamber 300, and the second flow rate reducing shield 500. Fluids such as fluid and blood containing bubbles are separated from the fluid and blood by a rapidly reduced flow rate and gravity to move and accumulate in the bubble removing chamber 600 to remove the micro bubbles. That is, it prevents the microbubbles outflow into the conduit.

As a result, the bubble removal device of the present invention eliminates the microbubble generated when applied to the fluid warming and rapid injection device, which is essential for the management of anesthesia of severe patients such as liver transplant surgery and open heart surgery, which is expected to cause massive bleeding, thereby preventing the occurrence of air embolism. Prevention can greatly increase patient safety.

In addition, the housing 100 is formed of a transparent material so that the generation and removal of bubbles can be visually confirmed.

On the other hand, the discharge side of the bubble removing chamber 600 is further provided with a rubber packing 610 that is opened by pressure, the rubber packing 610 plays the same role as a general check valve.

In addition, the inlet 110 and the outlet 120 are formed to have the same inner diameter.

Accordingly, the flow rates of the sap and blood discharged from the bubble removing device of the present invention by the inlet port 110 and the discharge port 120 having the same inner diameter to which the Bernoulli's principle is applied are the same as the flow rate before the flow into the bubble removing device. It does not cause a decrease in the flow velocity in the conduit before and after the bubble removing device.

Accordingly, since the flow rate in the conduit before and after the bubble removing device does not cause a drop in the flow rate, the fluid flow rate varies from the minimum 5 ml / min to the maximum 750 ml / min, depending on the clinical situation. Application is suitable.

Hereinafter, the operation of the bubble removing apparatus according to the present invention will be briefly described.

First, the bubble removing device A of the present invention is installed between the discharge side of the fluid heating and rapid injection device and the conduit.

Next, the fluid introduced through the inlet 110 is guided to the first chamber 200 inside the housing 100, and the flow of the fluid is converted to the direction in which the fluid flows against gravity through the primary flow rate reducing shield 400. Is reduced.

In addition, the fluid flows through the boundary surface 130 inclined upwardly, passes through the through hole 131, is introduced into the second chamber 300, and the flow rate is further reduced by the second flow rate reducing shield 500. It is discharged to the conduit through the discharge port 120.

That is, the second chamber 300 and the secondary flow rate reduction shield 500 have the effect of reducing the total flow rate in the housing 100, which increases the flow rate reduction effect inside the first chamber 200 on the streamline. To act.

Accordingly, the fine bubbles are integrated into the bubble removing chamber 600 by the flow rate reduced in the housing 100, which effectively discharges the bubbles through the bubble removing gourmet packing 610.

Hereinafter, the experimental results of efficiency and stability at low and high speeds after applying the bubble removing device of the present invention to the sap heating and rapid injector will be described.

The experimental conditions are as follows.

First, compare the bubble removal efficiency in the distal limb after setting the speed of the rapid injector to the minimum flow rate (2.5-50 mL / min), the medium flow rate (100-200 mL / min), and the high flow rate (500-700 mL), respectively.

Secondly, three times of testing for 10 minutes at low and medium flow rates and one minute at maximum flow rate. (When operating at the highest flow rate, the inlet drive time is limited and stops automatically due to the pressure load in the tube.)

Third, the above-mentioned flow rate classification is applicable to the present invention in a flow rate section of 100 ml / min or less and 350 ml / min or more, which is a flow rate section that cannot be applied in the conventional patented bubble removing device (the document 1). Test it.

Fourth, in the Proximal limb, bubbles are generated using a 20 ml syringe and injected slowly through the 3-way connector, and the maximum depth of the bubbles confirmed at high speed inflow into the chamber.

Fifth, in the distal limb, the conduit was fixed and fixed into the 1L perfusion water bottle to confirm the occurrence of bubbles.

The results of the experiment under the same conditions as shown in the following [Table 1].

As a result, the bubble removing device A of the chamber type of the present invention effectively removes the generated bubbles even at a low speed and a high speed inflow.

Moreover, even when the sap flows at high speed, the bubble moves and accumulates to the top by gravity at depth within 3 ~ 4cm from the water surface. This is because the flow rate is drastically reduced by the widening, and bubbles introduced into the chamber move and gather at the top of the chamber regardless of the flow rate.

Although the preferred embodiments of the present invention have been described in detail, the technical scope of the present invention is not limited to the above-described embodiments, but should be construed according to the claims. It will be understood by those skilled in the art that many modifications and variations are possible without departing from the scope of the present invention.

For example, in the above description, the bubble removing device has been described as applied to the sap heating and rapid injection device, but the present invention is not particularly limited thereto, and it can be applied to various devices for removing bubbles.

A-Bubble Eliminator 100-Housing
110-Inlet 120-Outlet
130-Interface 200-First Chamber
300-2nd Chamber 400-1st Flow Reduction Shield
500-Secondary Flow Reduction Shield 600-Bubble Removal Chamber

Claims (8)

A housing into which fluid is introduced and discharged;
First and second chambers formed in communication with the housing;
A first flow rate reducing shield for converting the flow of the fluid in the first chamber in a direction opposite to gravity;
A secondary flow rate reduction shield for reducing the flow rate of the fluid flowing through the second chamber; And
And a bubble removing chamber attached to the housing and in communication with the first chamber.
The method of claim 1,
And an inlet formed in the first chamber side of the housing and an outlet formed in the second chamber side of the housing, wherein the discharge side of the inlet is formed to face the primary flow rate reducing shield, and the inlet side of the outlet is the secondary flow rate. Bubble removing device of the sap heating and rapid injector, characterized in that formed to face the abatement shield.
The method of claim 1,
The apparatus of claim 1, further comprising an interface intersecting the housing to define the first and second chambers and having a through hole formed at a center thereof.
The method of claim 3, wherein
The boundary surface is the bubble removing device of the sap heating and rapid injector, characterized in that the inclined upward from the edge in contact with the housing to the center formed through holes.
The method of claim 1,
The housing is a bubble removing device of the sap heating and rapid injector, characterized in that formed of a transparent material.
The method of claim 1,
The first and second flow rate reducing shield is a bubble removing device of the sap heating and rapid injector, characterized in that formed in the '''cross section.
The method of claim 1,
The bubble removing device of the sap heating and rapid injector, characterized in that the discharge side of the bubble removing chamber is further provided with a rubber packing opened by pressure.
3. The method of claim 2,
The inlet and the outlet are bubble removing apparatus of the sap heating and rapid injector, characterized in that formed to have the same inner diameter.

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