KR20130059018A - Apparatus for generating the time-periodic pulsatile microflows by applying hydraulic head difference - Google Patents

Abstract

PURPOSE: A time periodic micro-precise pulsatile flow generating apparatus is provided to adjust the period and amplitude of a pulsatile flow implementing a perfect sinusoidal and to provide the forward pulsatile flow and the forward/backward pulsatile flow. CONSTITUTION: A time periodic micro-precise pulsatile flow generating apparatus includes a liquid container(3), a rotational motion apparatus, and a micro-channel(6). The liquid container is filled with a liquid. The rotational motion apparatus rotates at a regular angular velocity. The micro-channel is connected to the rotational motion apparatus. A pressure difference, which is periodically varied by the rotation of the liquid container, is generated at the micro-channel according to the rotation of the rotational motion apparatus so that the micro-channel implements a sinusoidal pulsatile flow. The liquid container is connected to one end of the micro-channel with micro-channel inflow tubing.

Description

Apparatus for generating the time-periodic pulsatile microflows by applying hydraulic head difference}

The present invention relates to a pulsatile flow generating device, and more particularly, using a hydraulic head difference based on the Bernoulli principle, a basic concept of fluid statics. Time using the principle of the head of the fluid to realize the fine and precise sinusoidal pulsating flow by generating the pressure difference that changes periodically with time by changing the height of the water surface as the filled liquid container rotates at a constant angular velocity. The present invention relates to a periodic microscopic pulse wave generator.

The pulsation flow generating device according to the present invention is designed to adjust the period and amplitude of the time-periodic pulsating flow, respectively, and the forwarding type by adjusting the height difference between the rotating shaft and the microchannel. And two types of pulsations can be implemented: back-and-forth standing type.

Pulsation refers to types such as blood flow in the blood vessels, for example, by repetitive and periodic contraction and relaxation of the heart. In the field of engineering, pulsations can be observed in many pumps, including syringe pumps, except for some, and these pulsations also exist in electrical circuits. In some applications, such pulsation flow should be suppressed depending on the purpose of use, and in others, appropriate use should be made. In the latter case, much effort is made to obtain a very regular pulsating flow, such as a sinusoidal wave rather than an irregular pulsating flow, which is more technically difficult than obtaining a constant pressure flow.

The hydraulic head is a hydrostatic term for the height of a column of water, and is associated with the potential energy of the water above it. According to Bernoulli's principle, the pressure difference (Δp) exerted by the water column is expressed as the product of the water density (ρ), the gravitational acceleration (g), and the water head difference (△ h), which is the height difference of the water column. Since both values are constant, the pressure difference is directly proportional to the head difference. Therefore, in order to obtain the desired pressure, the height of the water surface may be made by the corresponding head. The principle of siphon is a related concept, and the mercury (mmHg) unit is used to represent atmospheric pressure in the meteorological field.

Sinusoidal, a representative form of the periodic function, is obtained from the difference in the height of the rotor with respect to the time change when a rotor rotates the circumference at a constant angular velocity. As the rotor rotates, the shape of the water column is changed by the centrifugal force action, but the water head difference is determined only by the height difference between the top and the bottom of the water column, and is not affected by the shape of the water column.

Microfluidics is a field that deals with the technology of fluid flow through microchannels formed in microfluidic chips and plays an important role in recent bio-MEMS and power-MEMS. In addition to techniques for applying steady state flow in fluid flow in microchannels, there is a growing interest in techniques for applying unsteady state flow. In order to obtain the steady-state flow, it is necessary to generate a pressure difference that changes over time. The necessity for the development of such a device is continuously required because it is not easy to generate a minute and precise pressure difference with a conventional commercialized or laboratory proposed pump. have.

Goswami, P. and Chakraborty, S., "Energy transfer through streaming effects in time-periodic pressure-driven nanochannel flows with interfacial slip," Langmuir 26, 581-590, 2010) The energy conversion efficiency was simulated by introducing a sinusoidal pulsating flow into the technique of flowing an electrolyte solution into the channel to generate a streaming potential across the channel and recovering energy therefrom. The results show that increasing the frequency significantly increases energy conversion efficiency by several ten percent.

Leslie, DC, Easley, CJ, Seker, E., Karlinsey, JM, Utz, M., Begley, MR and Landers, JP, "Frequency-specific flow control in microfluidic circuits with passive elastomeric features," Nature Phys 5, 231-235, 2009) creates microchip circuits including fluid diodes and capacitors on two glass plates, and polydimethylsiloxane (PDMS), an excellent material between them. The film was inserted to make a microchip pump for pulsation generation. To operate this pump, the PDMS film must be repeatedly contracted and relaxed by periodically applying external pressure. However, such a method requires a complicated and high manufacturing cost to manufacture a microchip, and it is difficult to measure the pressure formed in the microchannel in real time.

In addition, Bethel et al. (Vedel, S., Olessen, LH and Bruus, H., "Pulsatile microfluidics as an analytical tool for determining the dynamic characteristics of microfluidic systems," J. Micromech. Microeng. 20, 035026, 2010). The pumps are self-made to implement periodic sinusoidal pulsations in the channel. The pump blocked the liquid reservoir with one PDMS film and repeated contraction and relaxation with a costly actuator that linearly reciprocates by the current, resulting in a high frequency pulsation flow of several tens of Hz.

Another device for generating pulsations can be found in the medical field, such as cardiopulmonary bypass. For example, Jones et al. (Jones, KA, Corera, CS and Hayes, RS, Pulsatile fluid delivery system, US Pat. No. 7,842,003 B2, 2010.11) focus on the principle of biomechanical operation of the left and right ventricles of the heart. Designed a device for administering blood and drugs to a patient during cardiopulmonary surgery. The amplitude and period of the pulsating flow resulting from this artificial pump are controlled by a microprocessor.

Weatherbee (P., Pulsatile blood pumping systems, US Patent 7,758,492 B2, 2010.7) developed an artificial heart pump that divides a spherical housing into two parts and acts as a left / right ventricle. The main feature of this device is that each chamber supplies blood while repeating contraction and relaxation by rotational movement. It is small in size and can be used in two types of surgery and implantation.

The two representative pulsating flow generating pumps have the following disadvantages.

Existing pumps including the above two inventions are difficult to obtain accurate sinusoidal pulsation flow, and only forward pulsation flow with only one direction flow can be obtained for design purposes. In addition, since the pressure range of the pump according to the present invention has an operating range of about 80 to 120 mmHg, that is, about 105 to 158 mbar, which is a normal blood pressure of the human body, it is difficult to generate a precise pressure in a range of several tens of mbar or less. In addition, the pump according to the above two inventions has many kinds of parts, and the design of the device is complicated, so that the manufacturing cost is high.

US patent registration US 7,842,003 B2 US patent registration US 7,758,492B2

Accordingly, an object of the present invention is to apply to the field requiring a fine pulsation flow that is not easy to achieve with a general pump, such as microfluidics, biomes and power memes pulsation flow to achieve a perfect sine wave as a precise pressure differential control It is to adjust the period and amplitude of and to provide forward and backward in situ pulsating flow.

In order to achieve the above object, the pulsation flow generating device according to the present invention is provided with a liquid container filled with a liquid and is connected to a rotary motion device that rotates at a constant angular velocity, and the rotary motion device, the rotary motion device is rotated As the pressure is generated by the rotation of the liquid container is periodically changed to include a microchannel to implement a sinusoidal pulsating flow.

The liquid container may be connected to one end of the microchannel by microchannel inlet tubing.

The rotary motion device may include a rotary shaft, a rotary table connected at right angles to the rotary shaft and having a rotary radius, and a liquid container connected to the rotary table.

The pulsation flow generating device according to the present invention includes a bearing for connecting the swivel and the liquid container to keep the liquid container always in an upright state regardless of the rotation angle, and a bearing disengagement so that the bearing does not leave the swivel. It may further comprise a prevention plug.

The pulsation flow generating device according to the present invention may further include a balance weight to maintain the center of mass on the rotation axis and to maintain a constant rotational angular velocity of the swivel.

Both ends of the microchannel are connected to the microchannel inlet tubing and the microchannel outlet tubing, and the microchannel inlet tubing is provided with a pressure gauge to measure the change in pressure difference in the microchannel.

In the pulsation flow generating device according to the present invention, the average pressure difference may be adjusted by adjusting the height difference between the rotating shaft and the microchannel.

In the pulsating flow generating device according to the present invention, two types of pulsating flows, forward and backward, are controlled by adjusting the height difference between the rotating shaft and the microchannel.

The rotation shaft is horizontally connected to the electric motor shaft to adjust the rotational angular velocity can be adjusted the period of the pulsating flow.

A connecting part fixing screw is installed at the connection portion connecting the rotating shaft and the rotating table to adjust the rotating radius of the rotating table so that the height difference between the rotating shaft and the liquid surface in the liquid container is varied, thereby controlling the amplitude of the pulsating flow.

The counterweight is located opposite the liquid container at the swivel, and the mass of the counterweight can be greater than the sum of the masses of the swivel, the liquid container and the bearing.

The counterweight can be installed to be movable with the counterweight fixing screw to position the center of mass on the axis of rotation using the principle of the lever.

In the pulsating flow generating device according to the present invention, a certain amount of liquid can continuously pass from the liquid container through the microchannel, and the flow rate exiting the liquid container is the same as the flow rate passing through the cross section of the microchannel. Using this principle, the relationship between the width, width, and change in liquid surface height over time of the liquid container can be determined.

The cross-sectional area of the microchannel inlet tubing connected to the liquid container and the microchannel inlet tubing connected thereto may be larger than that of the microchannel, thereby eliminating pressure loss due to inertia and friction of the liquid.

The pulsation flow generating device according to the present invention can obtain a nearly perfect sine wave pulsation flow and a fine and precise pressure difference, which cannot be realized by a conventional pump of a motor drive type such as a piston reciprocating type, a centrifugal force type, a gear rotating type, and the like. The reliability of the measurement result obtained by use is increased.

In addition, the period and amplitude of the pulsating flow can be adjusted by adjusting the angular velocity of the rotating shaft and the rotating radius of the rotating table, and the average pressure difference of the pulsating flow can be adjusted by adjusting the height difference between the rotating shaft and the microchannel, as well as the forward and backward movements. Two pulsation types in situ can be implemented.

In addition, the device configuration can be obtained as a rotating shaft, a swivel, a liquid container, a bearing, a counterweight, even with a simple and low production cost, it can be used as a useful device in the field of microfluidics.

Figure 1a is a diagram showing a sine wave form periodic function by the advance pulse wave in accordance with the present invention.
1B is a view showing a sine wave-shaped periodic function by forward and backward in situ pulsating flow according to the present invention.
Figure 2a is a view showing a method for obtaining the highest flow rate (that is, the case of ② of Figure 1a) by the pressure difference generator in the form of a periodic function for the implementation of the advanced pulsating flow in accordance with the present invention.
Figure 2b is a view showing a method for obtaining the lowest flow rate (that is, the case of ④ of Figure 1a) by the pressure difference generator in the form of a periodic function for the implementation of the advanced pulsating flow in accordance with the present invention.
Figure 3a is a view showing a method for obtaining the forward forward flow (that is, the case II of Figure 1b) by the pressure difference generator in the form of a periodic function for implementing the forward and backward in situ pulsating flow in accordance with the present invention.
Figure 3b is a view showing a method for obtaining a reverse reverse flow (that is, the case IV of Figure 1b) by the pressure difference generator in the form of a periodic function for implementing the forward and backward in situ pulsating flow in accordance with the present invention.
4 is a view showing a configuration showing a rotary motion device for generating a pulsating flow according to the present invention.
FIG. 5A is a view illustrating a state before assembly of the swivel and the bearing part of FIG. 4. FIG.
It is a figure which shows the state after assembly of the rotating table and the bearing part of FIG.
6 is a view showing the water surface of the liquid container and the fluid inside the liquid container according to the present invention.
7 is a graph showing pressure difference results generated over time in a microchannel by a forward pulse wave implemented using the apparatus according to the present invention.
8 is a graph showing the pressure difference result generated over time in the microchannel by the forward and backward in-situ pulsating flow implemented using the apparatus according to the present invention.

Hereinafter, with reference to the drawings, it will be described in more detail with respect to the pulsation flow generating apparatus of the present invention.

1A and 1B are diagrams illustrating a sinusoidal periodic function by forward and backward in-situ pulse waves according to the present invention. Referring to Figure 1a, it can be seen that the pulsating flow of the sinusoidal curve is generated as the liquid container rotates at a constant rotational angular velocity from the position of ① to the position of ④ by the pulsating flow generating device according to the present invention. At this time, the forward pulsation flow changes in a positive pressure range. Referring to FIG. 1B, as the liquid container rotates at a constant angular velocity from the position of I to the position of IV, sinusoidal pulsating flow is generated, and the forward and backward in situ pulsating flow has a pressure in a positive pressure range. The pressure increases to zero at position III and becomes the lowest pressure in the negative pressure range at position IV. That is, the forward and backward in situ pulsating flow has a sinusoidal curve in the positive and negative pressure ranges.

Figures 2a and 2b to obtain the highest flow rate (that is, the case of ② of Figure 1a) and the lowest flow rate (that is, the case of ④ of Figure 1a) by the pressure difference generator in the form of a periodic function for implementing the forward pulsating flow of Figure 1a It is a figure which shows a method. 2A and 2B, the pulsation flow generating device according to the present invention includes a rotary motion device and a microchannel 6. The rotary motion device has a liquid container 3 filled with liquid and can rotate at a constant angular velocity. The microchannel 6 is connected to the rotary motion device, and as the rotary motion device rotates, a pressure difference periodically changed by the rotation of the liquid container 3 may be generated to implement a sinusoidal pulsation flow. .

The liquid container 3 may be connected to one end of the microchannel 6 by a microchannel inlet tubing 5, and the rotary motion device is connected to the rotary shaft 1 at a right angle to the rotary shaft 1. A swivel table 2 having a radius of rotation, and a liquid container 3 connected to the swivel table 2. The other end of the microchannel 6 is also provided with a microchannel outflow tubing 7 through which the liquid passes through the microchannel 6 and finally exposed to the atmosphere.

At the heart of the pulsating flow generating device according to the invention is the head difference 8 which is the height difference between the height of the water surface 9 of the liquid inside the liquid container 3 and the microchannel outflow tubing 7. The head difference Δh of two points may be converted into the pressure difference Δp at two points from the density ρ and the gravitational acceleration g of the liquid using Equation 1 as follows.

According to Equation 1, as shown in FIG. 2A, when the liquid container 3 is positioned at the maximum height h _avg + h by rotation, the maximum pressure difference is generated in the microchannel 6, and the minimum Located at the height h _avg -h, it produces the minimum pressure difference.

The microchannel inlet tubing (5) is provided with a pressure gauge (4) can measure the change in pressure difference in the microchannel (6), by connecting the pressure gauge (4) to a computer in real time in the microchannel (6) You can check the change in pressure. The average pressure is the pressure difference corresponding to the height difference h _avg between the rotation shaft 1 and the microchannel 6, and the amplitude is the height between the rotation shaft 1 and the water surface 9 inside the liquid container 3. The pressure difference corresponding to the difference h is obtained.

Table 1 shows the range of head pressure and pressure difference that can be implemented by the pulsation flow generating device according to the present invention. For example, a head difference of 1 cm produces a pressure difference corresponding to 0.001 kg _f / cm ² by the above definition, which corresponds to 0.98 mbar.

Chicken pox (cm) Pressure difference kg _f / cm ² mbar 0.5 0.0005 0.49 One 0.001 0.98 2 0.002 1.96 3 0.003 2.94 4 0.004 3.92 5 0.005 4.90 10 0.010 9.81 15 0.015 14.71 20 0.020 19.61

Figure 3a is a view showing a method for obtaining the forward forward flow (that is, the case of II of Figure 1b) by the pressure difference generator in the form of a periodic function for implementing the forward and backward in situ pulsating flow according to the present invention, Figure 3b FIG. 1 is a diagram illustrating a method of obtaining a reverse reverse flow (that is, the case IV of FIG. 1B) by a pressure difference generator in the form of a periodic function for implementing forward and backward in situ pulsating flow. 3A and 3B, at the lowest pressure difference that can be obtained when the rotating shaft 1, the microchannel 6, and the horizontal microchannel outflow tubing 7 are at the same height, they have a negative head difference. As a result, the pressure also shows a negative value from Equation 1, so that a reverse flow of liquid flows from the microchannel outlet tubing 7 toward the liquid container 3 occurs.

In addition, in FIGS. 3A and 3B, the water head 8 only indicates that the water level 9 of the liquid and the height of the microchannel 6 are involved and are not related to the path. The time-periodic pressure difference obtained from the rotary pressure difference generator as shown in FIGS. 3A and 3B has a frequency f (i.e., period 1 / f, angular frequency 2πf), average pressure difference p _avg , amplitude p _amp , The forward and backward in-situ pressure differences are given by equations (2) and (3), respectively.

4 is a view showing a configuration showing a rotary motion device for generating a pulsating flow according to the present invention. Referring to FIG. 4, the rotary motion device includes a rotating shaft 1, a rotating table 2 connected at right angles to the rotating shaft 1, having a rotating radius, and a liquid container 3 connected to the rotating table 2. It includes. In addition, the bearing 10, the bearing departure prevention plug 16 and the counterweight 12 further includes. The bearing 10 connects the swivel table 2 and the liquid container 3 to keep the liquid container 3 always upright regardless of the rotation angle. The bearing detachment stopper 16 is connected to the swivel 2 with the bearing 10 therebetween so that the bearing 10 does not deviate from the swivel 2. The balance weight 12 maintains the center of mass (ie, the center of gravity) on the rotating shaft 1 and keeps the rotational angular velocity of the rotating table 2 constant.

The connecting portion 15 for connecting the rotating shaft 1 and the rotating table 2 may be designed to expand and reduce the rotating radius of the rotating table 2 according to a desired size by installing a connecting part fixing screw 13. In addition, the counterweight 12 is provided with a counterweight fixing screw 18 so that the counterweight 12 is movably installed to position the center of mass on the rotation axis 1 using the principle of the lever.

On the other hand, the counterweight 12 is located on the opposite side of the liquid container 3 in the rotary table 2, the mass of the counterweight 12 is the rotary table 2, the liquid container 3 and the bearing 10 It can be designed to be at least six times larger than the sum of the masses of. The rotating shaft 1 of the present invention can be used freely connected to a conventional electric motor shaft, the balance weight 12 is to ensure that the center of mass of the rotating table (2) is always on the rotating shaft (1). If the counterweight 12 and the rotating shaft-swivel connection 15 are too light, severe vibrations will occur when the center of mass is not matched, and if too heavy, a considerable amount of power is required to rotate the device.

Although several complex factors play a role in properly determining the mass W _P of the counterweight 12 and the mass W _J of the rotary shaft-swivel connection 15, the bearing 10 in the design of the device according to the invention. When the masses of the liquid container 3 and the swivel 2 are X, Y and Z, respectively, the mass of the counterweight 12 is set to 6 times or more of these mass sums, as shown in Equation 4, and the rotation shaft-swivel connection portion The mass of (15) is made 6 times or more of the mass of the bearing 10 and the liquid container 3, as shown in Formula (5).

In order to maintain the center of mass of the rotary table 2 and the liquid container 3, bearing 10, counterweight 12, etc. connected to the rotary shaft 1, the principle of the lever (ie, the object may be far from the rotary shaft). So that the entire center of mass moves towards the object). When the portion of the liquid container 3 is heavy with respect to the rotation axis 1, the counterweight 12 is coupled to the opposite side of the liquid container 3, and the distance from the rotation axis 1 is adjusted by the counterweight fixing screw 18. The swivel 2 may be in equilibrium.

5A and 5B are views each showing a state before and after assembly of the rotating table and the bearing part of FIG. 5A and 5B, the liquid container 3 is connected to the swivel 2, and the bearing 10 is a component that keeps the liquid container 3 always upright. When the liquid container 3 is integrally connected to the swivel 2 without the bearing 10, the liquid container 3 rotates together as the swivel 2 rotates, so that the upper and lower sides of the liquid container 3 are inverted and the liquid container 3 is inverted. (3) Liquids inside may be lost. To prevent this, a bearing 10 and a bearing departure prevention plug 16 are required, and the bearing-liquid container connecting rod 11 must be firmly attached to the bearing 10 and the liquid container 3.

6 is a view showing the water surface of the liquid container and the fluid inside the liquid container according to the present invention. With reference to FIG. 6, the volume determination and components of the liquid container 3 will be described.

The height from the bottom of the liquid container 3 to the liquid water surface 9 is S, and the width and width of the bottom of the liquid container 3 are W and B, respectively. Before operating the device according to the invention, the liquid is filled into the liquid container 3 through the liquid inlet 17 to maintain the initial surface, but when the device is operated, the liquid continues to flow into the microchannel 6. As a result, the liquid surface 9 goes down over time. The flow rate exiting the liquid container 3 is determined using the principle of material balance in continuum mechanics, which must be equal to the flow rate Q passing through the cross section of the microchannel 6. ), The relationship between the width, the width, and the change in the height of the water surface (ΔS) over time (Δt) can be seen from the following equation (6).

In addition, Equation 7 summarizes Equation 6 with respect to the height change ΔS of the water surface over time Δt, and expresses the error% by introducing the rotation frequency f. Once the allowable error in the application conditions of the device is determined from Equation 7, it is possible to determine the width and width of the liquid container 3 suitable for it.

As shown in FIG. 6, an inlet tubing connecting pipe 14 for supplying liquid to the microchannel 6 is provided under the liquid container 3. The size of the cross-sectional area of the inlet tubing connecting pipe 14 and the microchannel inlet tubing 5 connected thereto is designed to be 10 times larger than the cross-sectional area of the microchannel 6 so that there is no pressure loss due to inertia and friction of the liquid. Can be.

FIG. 7 is a graph showing a pressure difference result generated over time in a microchannel by performing the forward pulsation flow experiment described in FIGS. 1A, 2A, and 2B. In this experiment, the microchannel 6 made of PDMS had a width of 50 μm, a height of 250 μm, and a length of 3 cm, and the height difference between the microchannel 6 and the rotating shaft 1 determining the average pressure difference was 19 cm. The distance between the rotating shaft 1 and the liquid container water surface 9 was set to 8 cm. As a result, the liquid container 3 has a height difference of up to 27 cm and at least 11 cm by the rotational movement.

The rotary shaft 1 is connected horizontally with a conventional electric motor shaft. In this setup, two rotational frequencies of 0.5 Hz (top graph in Fig. 7) and 2 Hz (bottom graph in Fig. 7) were carried out. To obtain these frequencies, the electric motor shaft was 30 rpm and 120 rpm (i.e., 30 times). Per minute and 120 times per minute). A pressure gauge (4) was installed in the microchannel inlet tubing (5) immediately before the microchannel (6) and connected to a computer so that the change in pressure difference during the rotational movement of the liquid container (3) was recorded in real time. .

The pressure difference in millibars (mbar) is almost identical to the head head difference 8 in cm (ie, 1 cm = 0.98 mbar). That is, as shown in FIG. 7, obtaining the maximum pressure difference 27 mbar and the minimum pressure difference 11 mbar shows that the pulsation flow generating device according to the present invention has very fine and precise performance. In addition, the number of sinusoidal pulses of 5 and 20 times for 10 seconds respectively corresponded to the frequency of 0.5 kHz and 2.0 kHz, respectively, and there was little time lag due to friction or inertia caused by flow.

FIG. 8 is a graph showing pressure difference results generated over time in a microchannel by performing the forward and backward in situ pulsating flow experiments described with reference to FIGS. 1B, 3A, and 3B. At this time, the height of the rotating shaft 1 and the microchannel 6 was made to match, and the height difference of the rotating shaft 1 and the liquid container surface 9 was 8 cm. The rotation frequency was set to 0.5 Hz (upper graph in FIG. 8) and 2 Hz (lower graph in FIG. 8) as in Example 1.

At this time, the change of the pressure difference over time was 5 and 20 sine wave pulses for 10 seconds between about -8 mbar and 8 mbar, respectively, so that the frequencies corresponded to 0.5 Hz and 2.0 Hz respectively. Thus, it can be seen that the pulsation flow generating device according to the present invention has very fine and precise performance.

As described above, the pulsation flow generating device according to the present invention can obtain a fine and precise pressure difference with the sine wave-shaped pulsation flow, and adjust the period and amplitude of the pulsation flow by adjusting the angular velocity of the rotation axis and the rotation radius of the swivel, respectively. By adjusting the height difference between the rotational axis and the microchannel, two types of pulsation flows can be realized, as well as the control of the average pressure difference of the pulsation flows.

In addition, the device configuration can be used as a useful device in the field of microfluidics because the device configuration can be obtained with a simple and low manufacturing cost as a rotating shaft, a swivel, a liquid container, a bearing, a balance weight.

Although described above with reference to the embodiments, those skilled in the art can be variously modified and changed within the scope of the invention without departing from the spirit and scope of the invention described in the claims below. I can understand.

1: rotating shaft 2: swivel
3: liquid container 4: pressure gauge
5: Microchannel Inlet Tubing 6: Microchannel
7: Microchannel Outflow Tubing 8: Chicken Pox
9: sleep of liquid 10: bearings
11: bearing-liquid container connecting rod 12: counterweight
13: connection fixing screw 14: inlet tubing connector
15: Rotating shaft-swivel connection 16: Bearing departure prevention plug
17: liquid inlet 18: counterweight set screw

Claims (14)

A rotary motion device having a liquid container filled with liquid and rotating at a constant angular velocity; And
And a microchannel connected to the rotary motion device and generating a sinusoidal pulsation flow by generating a pressure difference periodically changed by the rotation of the liquid container as the rotary motion device rotates. The method of claim 1,
And the liquid container is connected to one end of the microchannel by a microchannel inlet tubing. The method of claim 2,
The rotary motion device,
A rotating shaft;
A swivel table connected to the rotation axis at a right angle and having a rotation radius; And
And a liquid container connected with the swivel. The method of claim 3,
A bearing for connecting the swivel and the liquid container to keep the liquid container always upright regardless of the rotation angle; And
The pulsation flow generating device further comprises a bearing departure prevention stopper to prevent the bearing from leaving the swivel. 5. The method of claim 4,
And a balance weight to maintain a center of mass on the rotation axis and to maintain a constant rotational angular velocity of the swivel. The method of claim 1,
Both ends of the microchannel are connected to a microchannel inlet tubing and a microchannel outlet tubing, respectively, and the microchannel inlet tubing is provided with a pressure gauge to measure the change in pressure difference in the microchannel. The method of claim 3,
Pulsating flow generating device, characterized in that the average pressure difference is adjusted by adjusting the height difference between the rotating shaft and the microchannel. The method of claim 3,
The pulsation flow generating device, characterized in that two types of pulsating flow forward and forward and backward can be adjusted by adjusting the height difference between the rotating shaft and the microchannel. The method of claim 3,
The rotating shaft is connected to the electric motor shaft horizontally, the pulsating flow generating device characterized in that the period of the pulsating flow is adjusted by adjusting the rotational angular velocity. The method of claim 3,
A connecting part fixing screw is installed in the connecting portion connecting the rotating shaft and the rotating table to adjust the rotating radius of the rotating table so that the amplitude difference of the pulsating flow is controlled by varying the height difference between the rotating shaft and the liquid surface in the liquid container. Generating device. The method of claim 5,
The counterweight is located opposite the liquid container at the swivel, and the mass of the counterweight is greater than the sum of the masses of the swivel, the liquid container and the bearing. The method of claim 11,
The counterweight is a pulsation flow generating device, characterized in that installed using the principle of the lever lever so that the center of mass on the axis of rotation is installed with a counterweight fixing screw. The method of claim 3,
The width of the liquid container using the principle that a constant amount of liquid is continuously passed from the liquid container through the microchannel, and the flow rate exiting the liquid container is equal to the flow rate passing through the cross section of the microchannel, A pulsation flow generator, characterized in that the relationship between the width and the change in the liquid surface height over time is determined. The method of claim 3,
Pulsating flow characterized in that the cross-sectional area of the microchannel inlet tubing connected to the liquid container and the microchannel inlet tubing connected thereto is larger than that of the microchannel to remove pressure loss due to inertia and friction of the liquid. Generating device.

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