KR20130042230A - Assembly of temporary abutment or fixture for bone and skin regeneration - Google Patents

Abstract

PURPOSE: A temporary abutment assembly or a temporary implant assembly for regeneration of a soft tissue and a bone tissue is provided to perform simultaneous installation of a temporary abutment and enlargement of alveolar bone. CONSTITUTION: A temporary abutment assembly for regeneration of a soft tissue and a bone tissue comprises: an abutment body(10) which is formed at the lower portion and fixed in an implant planted in the bone tissue; a shielding film(30) which is protruded at the outer circumference of abutment in a sheet form; and a fixing screw(20) for fixing the shielding film to the abutment. [Reference numerals] (AA) Drawing 1a; (BB) Drawing 1b; (CC) Drawing 1c;

Description

Assembly of temporary abutment or fixture for bone and skin regeneration

The present invention relates to a temporary abutment combination or temporary media combination that is fixed to the media to fix the growth factors, scaffolds and shielding membranes in regenerating soft and bone tissues such as gingiva, skin, ligaments and muscles.

The inventors have an abutment having a stick-like skeletal piece having the property of bending deformation in the Republic of Korea Patent 1009698890000 (20100706) so that the skeletal piece to serve as an external skeletal bone of the alveolar bone is not enough bone tissue is used Bone dilation of the alveolar bone is simplified, and as the abutment is fastened or detached to the median body placed in the alveolar bone, as the bone fragment is installed and removed, the operation is simplified and the bone dilation is easily performed. As the skeletal piece can be easily bent and deformed according to the dilatation condition, a mechanism was developed to provide a new type of temporary abutment for osteoplasty that can be performed more precisely. This technique could not be accompanied by soft tissue or gingival regeneration, so that the normal normal gingival or muscle tissue was implanted or extended at the site where bone augmentation was needed to completely cover the skeletal piece, thereby crushing the fractured bone for internal bone augmentation. At the time of bone expansion, additional surgical or gingival implantation was performed to return the extended peripheral normal gingiva or muscle tissue to its original position.

Since then, the inventors have developed a technology for regenerating soft tissues and bone tissues such as gingiva, skin, ligaments and muscles, as well as tissue regeneration of bone tissues alone, using a shielding membrane, scaffolds and growth factors.

Because of this, it is no longer necessary to transplant or extend the surrounding normal gingival or muscle tissue for bone dilation.

In addition, the gingiva around the missing skin or the extraction of the tooth contraction into the empty space is reduced to a sufficient tissue regeneration space by reducing the area where the tissue should be regenerated.

In order to prevent the contraction of the surrounding soft tissues and to maintain the space and shape in which the tissues should be regenerated, using a mechanism to support the regeneration of the tissues into functional and morphologically normal tissues and bone tissues. It is a mechanism for fixing the shielding membrane having the shape-keeping ability located in the outermost layer to the open upper end of the temporary abutment combination that fixes the mediated body implanted in bone tissue or the temporary median body assembly temporarily implanted in bone tissue.

In regenerating soft and bone tissue such as gingiva, skin, ligaments, and muscles, as a temporary abutment combination or temporary media combination, which is fixed to the media for fixing the growth factors, shields, scaffolds and barriers, tissues or organs There is a need to improve reproducibility and integrity.

The present invention, in order to solve this problem, the temporary abutment combination is an abutment body is inserted into the open upper end of the body of the abutment body is fixed to the body of the body implanted in bone tissue; A shielding film formed to protrude from an outer circumferential surface of the abutment body in a sheet shape having a property of bending deformation; Consists of a fixing screw for fixing the shielding film to the abutment, the portion filled with the scaffold for bone regeneration and the absorbent scaffold for soft tissue regeneration in a shape in which the shielding film is extended to the outside of the abutment body While maintaining the shape of the bone tissue and soft tissue regeneration site while being in close contact, the abutment body and the shield and fixing screws are removed from the media when the regeneration procedure is completed.

According to the temporary abutment for bone augmentation according to the present invention, the temporary abutment for the formation of temporary artificial teeth and prosthetic or gingival appearance and bone augmentation of the alveolar bone can be performed simultaneously. In particular, the implantation procedure can be applied immediately after extraction even for alveolar bone requiring bone expansion. In addition, the process of bone augmentation of the alveolar bone, in which crushed bone is used, is simplified, and the bone augmentation operation is simplified, and thus, the bone augmentation is easily performed.

Figure 1a of Figure 1 is a front view of the temporary abutment combination for tissue regeneration of soft and hard tissue according to an embodiment of the present invention is connected to an implant implanted in bone tissue to support the soft tissue while fixing the shielding membrane to prevent shrinkage,
Figure 1b is a combination state of the temporary abutment combination and shielding membrane for tissue regeneration of soft and hard tissues according to an embodiment of the present invention,
Figure 1c is a perspective view of a temporary abutment combination and shielding membrane for tissue regeneration of soft and hard tissues according to an embodiment of the present invention,
Figure 2a of Figure 2 is a front view of the temporary medium combination for soft tissues and hard tissue regeneration according to an embodiment of the present invention is implanted in the bone tissue to fix the shielding membrane and the shielding membrane to support the soft tissue to prevent water
Figure 2b is a perspective view of a temporary medium combination and shielding membrane for tissue regeneration of soft and hard tissues according to an embodiment of the present invention,
Figure 2b is a cross-sectional view of the combination of the temporary medium for the tissue regeneration of soft and hard tissue according to an embodiment of the present invention,
Figure 3 is an example of the shielding film reinforced with a mesh for maintaining the shape according to an embodiment of the present invention,
4 is a view showing a manufacturing procedure of the tissue regeneration shape retention shielding film;
5 is connected to the temporary abutment to the media for bone regeneration and gingival regeneration in the extracted alveolar bone, inserting a synthetic bone scaffold for bone regeneration and collagen sponge scaffold for gingival tissue regeneration and Teflon sheet shielding membrane Photographs showing gross findings with the temporary abutment and shield removed after fixation in the temporary abutment,
Figure 6 is a temporary media in bone bone regeneration (a) bone extraction and gingival tissue regeneration in the remaining bone tissue (b) filling the synthetic bone for bone regeneration (c) collagen sponge scaffold for soft tissue regeneration After filling (d), photographs showing the process of fixing the titanium sheet shielding film to the temporary medium (e) with a set screw.

Temporary abutment combination and the abutment body is formed in the lower portion is inserted into the open upper end of the body of the abutment fixed to the body of the implanted bone tissue; A shielding film formed to protrude from an outer circumferential surface of the abutment in a sheet shape having a bending deformation property; And a fixing screw for fixing the shielding membrane to the abutment, wherein the shielding membrane is filled with a growth factor and / or a scaffold-filled portion for bone regeneration and a growth factor and / or an absorbent scaffold-filled portion for soft tissue regeneration. While maintaining the shape of the bone tissue and soft tissue regeneration site while being in close contact with the abutment body extended shape, and when the regeneration procedure is completed, the abutment body and the shielding membrane and the fixing screw is removed from the buried body.

Temporary abutment combination:

In Figure 1a, 1b and 1c of Figure 1 the temporary abutment combination 100 is composed of a fixing screw 20 for fixing the abutment body 10 and the shielding film. The structure of the temporary abutment body 10 is an external screw having an insertion end 11 inserted into the open upper end of the body 50 placed in the bone tissue 40 at the bottom thereof and fixed to the internal thread of the body. (12) is formed below the insertion end, there is a protrusion 13 of various heights for maintaining the growth factor and / or scaffold filling space of the bone tissue and soft tissue regeneration site, the shape of the sheet There is an internal screw 14 at the top to fasten the fixing screw through the hole 31 formed in the shielding film 30, and a driver groove 15 is formed below the internal screw to fasten the abutment body to the embedding body. . The fixing screw 20 is formed with an outer thread portion 21 fastened to the inner threaded portion of the upper end of the temporary abutment, and a driver groove 22 for fastening the fixing screw to the abutment is formed at the upper end. In Figure 1a, the shielding membrane supports the soft tissue (1) while preventing the contraction to secure the space of the area to be regenerated.

Temporary carcass combinations include temporary carcasses implanted in a portion of the remaining bone tissue when the defects of soft and bone tissues are so extensive that the carcass cannot be implanted; A shielding film formed to protrude from an outer circumferential surface of the abutment body in a sheet shape having a property of bending deformation; The shielding membrane is composed of a fixing screw fixed to the temporary medium, and the barrier membrane is filled with a growth factor and / or a scaffold-filled portion for bone regeneration and a growth factor and / or an absorbent scaffold-filled portion for soft tissue regeneration. While maintaining the shape of the bone tissue and soft tissue regeneration site while being in close contact with the shape of the temporary medium to expand the body, when the regeneration procedure is completed, the temporary medium, the shielding membrane and the fixing screw is characterized in that it is removed from the bone tissue.

Temporary Media:

In Figures 2a, 2b and 2c of Figure 2, the temporary medium body combination 200 is composed of a fixing screw 70 for fixing the temporary body body 60 and the shielding membrane. The structure of the temporary medium body body is formed in the lower portion of the screw portion 61 is placed in the remaining bone tissue 80, the protrusion of various heights for maintaining the sex factor and / or the scaffold filling space of the bone tissue and soft tissue regeneration site There is a stage 62, and there is an internal screw 63 at the top to fasten the fixing screw through a hole formed in the sheet-shaped shielding film 90 for shape maintenance, and the temporary media body is placed in the bone tissue under the internal screw. The driver groove 64 is formed. The fixing screw 70 is formed with an external thread portion 71 fastened to the inner threaded portion of the upper end of the temporary abutment, and a driver groove 72 for fastening the fixing screw to the abutment is formed at the upper end. In Figure 2a, the shielding membrane supports the soft tissue (1) while preventing the contraction to secure the space of the area to be regenerated.

The material of the shielding film used in the present invention is PCL, PLA, PLGA, PGA synthetic absorbent polymer material; Natural absorbent polymers of alginic acid, chitosan, collagen, hyaluronic acid, cellulose and mixtures thereof, poly (vinylidene fluoride), poly (tetrafluoroethylene), poly (vinyl alcohol), poly (hydroxyalkanoate), poly (ethylene terephthalate), poly (butylene terephthalate), poly (methyl methacrylate), poly (hydroxyethyl methacrylate), poly (N-isopropylacrylamide), poly (dimethyl siloxane), polydioxanone, polypyrrole, poly (glycolic acid), poly (lactic acids), poly (ethylene oxides), synthetic polymers of poly (lactide-co-glycolides), poly (s-caprolactone), polyanhydrides, polyphosphazenes, poly (ortho-esters) and polyimides; It is selected from the group consisting of metal thin films of titanium and stainless steel.

The shielding membrane has pores less than 0.01 ~ 30㎛ preventing neighboring bacteria or cells from passing through or growing inside. Externally exposed sites prevent the invasion of bacteria and the escape of body fluids from defective tissues or organs. On the other hand, the shielding film installed inside the tissue or organ shields other adjacent tissues or organs from interfering with each other. This allows the tissue or organ to be regenerated to be integral with the surrounding normal tissue or organ.

The thickness of the shielding film is 0.01-0.5 mm. If it is thinner than 0.01mm, it is easily deformed to external stimulus, and if it is thicker than 0.5mm, it is difficult to mold.

In the present invention, the shielding film may be composed of a multilayer of 2 to 5 layers. In order to contain the growth factor in the shielding film, a plurality of shielding film layers may be formed by adding a shielding film layer of hydrophilic material. The outer layer is physicochemically stable to block external stimuli and may be composed of a layer containing growth factors inside.

In the present invention, the barrier membrane configured for the combination of tissue or organ regeneration medium or temporary abutment may have a non-porous sheet or pores. Preferably, the pores of the shielding film are not only a shielding film made of nanofibers having pores of 0.01-30 µm or more, but also a shielding film obtained by compressing a collagen sponge, as well as a sheet or film having no pores in the shielding film. Bacteria do not penetrate the sheet or film that has no pores in the shielding membrane to prevent infection, and nanofibers or compressed sponges return to their original unfolded shape even if they are deformed to conform to the curved shape, but the sheet or film is deformed. It has the advantage of being maintained.

In the present invention, the shielding film configured for the tissue or organ regeneration kit may increase the strength as a reinforcing layer, and for this, the material of the reinforcing layer may be polycaprolactone or polylactic acid, polyglycolic acid, copolymer of lactic acid and glycoic acid, titanium and It may be a metal selected from stainless steel. Preferably, in order to maintain the shape of the shielding film, a synthetic polymer layer or a metal layer may be formed between the plurality of shielding film layers or under a single layer. This layer may be composed of plastic polycaprolactone or polylactic acid, polyglycolic acid and copolymers of the above three materials or metals of titanium or stainless steel, the shape may be a mesh layer, and the thickness may be 0.01 to 0.5. mm, and may be formed to be extended in the outward direction from the center of the shielding film.

Reinforced shield for shape retention:

In FIG. 3, the mesh is fixed between the shielding layer 300, which is composed of a metal or synthetic polymer mesh 101, and different shielding layer layers 102 and 103, which are reinforced to maintain the shape of the shielding layer. It can be configured to be extended to.

If skin damage is widespread, a custom-made shield can be used to maintain the scaffolds in the outer shape and defect area.

3D shield film manufacturing:

In FIG. 4, a 3D image of skin tissue is obtained by CT (computertomography) or a 3D optical analyzer, and a 3D shape in which skin tissue is reproduced is obtained by a simulation program. This 3D shape and simulation program is used to design a shield that maintains shape during skin tissue regeneration, and a laser photopolymerization shield using polyepoxy polymer, a thermoplastic shield using polycarabolactone (PCL) polymer, or PEEK resin or PTFE. An engineering polymer block, such as a resin, is produced in a computer milling center to form a shield. Place a temporary media to fix the barrier on the damaged tissue and inject the rhBMP-2 and collagen scaffold into the volume of the missing skin tissue. .

In the present invention, the shielding film may be composed of a single layer or a multilayer of 2 to 5 layers.

Growth Factors and Scaffolds:

In the present invention, growth factors, scaffolds or growth factors and scaffolds may be used together.

Growth factors for bone forming protein components that can be used in the present invention are BPM-2, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8, BMP-9, BMP-10, BMP-11 , BMP-12 and BMP-13.

The material of the scaffold used in the present invention is a biodegradable polymer material of PCL, PLA, PLGA, PGA, chitosan, alginic acid, collagen, hyaluronic acid, chondroitin, glucosamine, hemicellulose or a composite material thereof, synthetic bone, allogeneic bone, heterogeneous Bone, demineralized bone or cadaveric dermis.

Claims (9)

A temporary abutment combination or temporary media combination that is fixed to the media to fix growth factors, shields, scaffolds and barriers in regenerating soft and bone tissue such as gingiva, skin, ligaments and muscles.
The abutment body of claim 1, further comprising: an abutment body formed at a lower end of the insertion body inserted into the open upper end of the media, and fixed to the media; A shielding film formed to protrude from an outer circumferential surface of the abutment body in a sheet shape having a property of bending deformation; It consists of a fixing screw for fixing the shielding film to the abutment, the growth factor, scaffold or growth factor for bone regeneration and the growth factor, soft absorbent scaffold or growth factor for regeneration While the shielding membrane is in close contact with the expanded portion outside the abutment body, the shape of the bone tissue and soft tissue regeneration site is maintained, and when the regeneration procedure is completed, the abutment body and the shielding membrane and the fixing screw are A temporary abutment combination or a temporary media combination, characterized in that it is removed from the media.
The method according to claim 1, wherein the temporary site of implantation in a portion of the remaining bone tissue when the defects of the soft tissue and bone tissue is so extensive that the media can not be implanted; A shielding film formed to protrude from an outer circumferential surface of the abutment body in a sheet shape having a property of bending deformation; The shielding membrane is composed of a fixing screw fixed to the temporary medium, and a growth factor, a scaffold or a growth factor for bone regeneration, and a growth factor for regenerating soft tissue, an absorbent scaffold or a growth factor and an absorbency As the shielding membrane is in close contact with the shape of the scaffold that is expanded to the outside of the temporary medium body, the form of bone tissue and soft tissue regeneration site is maintained, and when the regeneration procedure is completed, the temporary medium and the shield and fixing screw are removed from the bone tissue. And a temporary abutment combination or temporary media combination.
The method according to claim 1, 2, 3, PCL, PLA, PLGA, PGA synthetic absorbent polymer material, alginic acid, chitosan, which has a space retention ability to prevent the surrounding skin or gingival tissue from contracting into the defect or expansion site, Natural absorbent polymers of collagen, hyaluronic acid, cellulose, or mixtures thereof, poly (vinylidene fluoride), poly (tetrafluoroethylene), poly (vinyl alcohol), poly (hydroxyalkanoate), poly (ethylene terephthalate), poly (butylene terephthalate), poly (methyl methacrylate), poly (hydroxyethyl methacrylate), poly (N-isopropylacrylamide), poly (dimethyl siloxane), polydioxanone, and polypyrrole, poly (glycolic acid), poly (lactic acids), poly (ethylene oxides), poly ( consisting of lactide-co-glycolides), poly (s-caprolactone), polyanhydrides, polyphosphazenes, poly (ortho-esters) and synthetic polymers of polyimides, and metal thin films of titanium and stainless steel A temporary abutment, or combinations temporary sheet corrosion body combination, characterized in that the shielding film.
The temporary abutment combination or temporary media combination according to claim 4, wherein the shielding film is composed of two to five layers of multilayers.
The temporary abutment combination or temporary media combination according to claim 4, wherein the shielding membrane is a non-porous sheet or a closed shielding membrane with pores.
The temporary abutment combination or temporary media combination according to claim 4, wherein in the case of extensively damaged soft or bone tissue, the shield is a shield designed and manufactured to maintain the shape of the soft or bone tissue to be regenerated.
The temporary abutment combination or temporary media combination according to claim 4, wherein the shielding film is a shielding film having increased strength as a reinforcing layer.
The temporary abutment combination according to claim 8, wherein the material of the reinforcing layer is a material selected from the group consisting of polycaprolactone or polylactic acid, polyglycolic acid, copolymers of lactic acid and glycoacid, titanium and stainless steel. Or temporary media

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