KR20130012733A - Complex nozzles for electrospinning, an electrospinning device comprising the same, a nano fiber structure and a nano rod manufactured by using the electrospinning device - Google Patents

Abstract

PURPOSE: A composite nozzle for electrospinning and an electrospinning apparatus with the same are provided to selectively remove only sheath nanofibers and to easily control electric conductivity and release speed of a spinning solution. CONSTITUTION: A composite nozzle for electrospinning comprises an outer nozzle(1) and two or more inner nozzles(2,3) which are placed inside the outer nozzle side by side. The external diameter and internal diameter of the inner nozzle are 0.002-80 mm and 0.001-30 mm, respectively. The external diameter and internal diameter of the outer nozzle are 0.005-300 mm and 0.004-200 mm, respectively.

Description

Complex nozzles for electrospinning, an electrospinning device comprising the same, a nano fiber structure and a nano rod manufactured by using the electrospinning device}

The present invention relates to an electrospinning composite nozzle, an electrospinning apparatus including the same, a nanofiber structure and a method for manufacturing the same, a polymer nanorod and a method for manufacturing the same.

Hyundai is transforming itself into a knowledge-intensive high-tech industry beyond the traditional simple industry by combining with nano technology (NT), bio technology (BT), and information technology (IT). In particular, the combination with nanotechnology is prominent, and recently appeared nano fiber (nano fiber) is a representative example.

Nanofiber refers to a fiber having a nanometer (nm) thickness of the fiber, and has excellent mechanical properties relative to mass as well as excellent surface area, and has been applied to a wide variety of fields. Recently, as the composite functional nanofibers can be manufactured, nanofibers capable of drug delivery can also be prepared. The characteristics of such nanofibers are known to be suitable for preparing nanofiber supports, which are essential for tissue engineering, which is recognized as a future technology. That is, most of the complex protein bodies constituting the extracellular matrix have a nano diameter fiber structure, so that the complex protein bodies can be replaced by using the nanofiber support. In addition, nanofibers may be utilized in various fields such as filters, composite materials, optical materials, and electronic materials. Electrospinning technology of the nanofiber manufacturing technology is recognized as a very excellent technology in terms of variability and diversity as well as industrial aspects.

Electrospinning technology is not only applicable to a wide range of polymer materials, but it is also possible to manufacture fiber webs easily by mixing and spinning various materials, such as metal and carbon, which are difficult to process in the polymer solution. Spinning is also possible with a polymer solution.

Historically, electrospinning was deformed during electrostatic spraying in 1795, when Bose applied high voltage to water droplets suspended by capillary ends due to surface tension, which resulted in a polymer solution or melt with sufficient viscosity. After seeing the formation of fibers when subjected to electrostatic forces, it was known in the early 1900s that solid fibers erupted when electricity was sealed to electricity. Formhals in 1934 set up a device for the production of polymer fibers using electrostatic forces. Developed and patented, the process of spinning fibers by this method is called electrospinning.

In general, there are two main factors that affect electrospinning. As the first factor, factors such as the concentration of the polymer solution, viscosity, surface tension, dielectric constant, and solvent type can be mentioned.The second factor is the inner / outer diameter of the electrospinning nozzle, the strength of the voltage, and the electrospinning. Process factors such as the distance between the nozzle and the collecting part can be cited. In addition, the ambient atmospheric conditions during electrospinning are also important factors.

Meanwhile, in developing new nanostructures using electrospinning, it is very important to develop a new electrospinning nozzle. For example, in coaxial electrospinning technology, the inner nozzle is co-linear with the axis of the outer nozzle, but the diameter of the inner nozzle is smaller than the inner diameter of the outer nozzle (Polymers for advanced technologies, 22 (3), 310-). 317, 2010). By performing the electrospinning while supplying different solutions in the coaxial electrospinning technology, it is possible to produce a core / shell-type nanofiber structure.

However, nanofibers produced by electrospinning can be spun to have an infinite length. Therefore, there is almost no method for producing nanorods using existing electrospinning techniques. In other words, electrospinning technology may be an advantage, while it may be a major disadvantage.

In one study, chemical treatment based on the decomposition and crystallization of polymer materials led to weak mechanical properties in a certain length, and then, when appropriate physical external energy was used, cleavage occurred in these parts and finally nano The method by which rods were made was studied (Macromolecular Rapid Communications, 29 (14), 1331-1236, 2008). However, the manufacturing method of the nanorods has a fatal disadvantage of reducing the molecular weight of the polymer used in the production of the nanorods. Therefore, existing methods for manufacturing nanorods are being developed through other technologies.

The most common method for producing nanorods is to fill the raw material for manufacturing nanorods in a mold having nanopores and then remove the mold (New J. Phys 11 075018, 2009). However, since the length and thickness of the nanorods are already determined by the structure of the mold, it is impossible to manufacture them in various forms. In particular, it is not only complicated to manufacture a mold for manufacturing a nano-rod, but when the mold is removed, it cannot be reused, and thus has a great disadvantage in terms of productivity.

Accordingly, while the length and thickness of the nanorods are easily controlled, development of a method for producing a productive nanorod is urgently required.

An object of the present invention is to provide an electrospinning composite nozzle, an electrospinning apparatus including the same, a nanofiber structure, a method for producing the same, a polymer nanorod and a method for producing the same.

The present invention is a means for solving the above problems, the external nozzle; And it provides an electrospinning composite nozzle comprising two or more inner nozzles arranged side by side inside the outer nozzle.

The present invention provides another means for solving the above problems, a solution supply unit for storing and supplying the solution for the external nozzle and the solution for the two or more internal nozzles; A composite nozzle comprising at least one electrospinning composite nozzle according to the present invention connected to the solution supply for spinning the solution for the external nozzle and the solution for the two or more internal nozzles stored in the solution supply to produce a nanofiber structure part; A collecting unit for collecting the nanofiber structure radiated from the composite nozzle unit; And the collecting part and the composite nozzle part for charging the external nozzle solution and two or more internal nozzle solutions. Or it provides an electrospinning apparatus comprising a voltage applying unit electrically connected to the collecting unit and the solution supply unit.

The present invention is another means for solving the above problems, Core nanofibers in which two or more components are formed in a discontinuous, crossed or uncrossed state; And sheath nanofibers surrounding the core nanofibers.

As another means for solving the above problems, the present invention comprises the steps of preparing a solution for the sheath nanofibers and a solution for two or more core nanofibers; And it provides a method for producing a nanofiber structure according to the invention comprising the step of electrospinning the prepared solution for the sheath nanofibers and two or more core nanofibers.

The present invention as another means for solving the above problems, provides a polymer nano-rod containing at least one polymer material.

As another means for solving the above problems, the present invention includes the step of selectively removing only the sheath nanofibers of the nanofiber structure prepared by the method for producing a nanofiber structure according to the present invention Provided are methods of making the rods.

The electrospinning composite nozzle of the present invention comprises an outer nozzle and two or more inner nozzles arranged side by side inside the outer nozzle, and using the electrospinning apparatus of the present invention comprising the electrospinning composite nozzle When manufacturing a nanofiber structure, it is possible to produce a nanofiber structure having a novel structure comprising a core nanofibers, which are formed at two or more components intersected or discontinuously, and a sheath nanofiber surrounding the core nanofibers. In addition, by selectively removing only the sheath nanofibers from the nanofiber structure of the present invention, a polymer nanorod can be easily obtained. In particular, when manufacturing the nanofiber structure of the present invention, when using a hydrophilic polymer material and a hydrophobic polymer material as a component of the core nanofibers can be prepared amphiphilic polymer nanorods. In addition, when manufacturing the nanofiber structure of the present invention, by adjusting the applied voltage, the electrical conductivity of the spinning solution and the dissolution rate, it is possible to easily control the length of the polymer nanorods.

1 is a view showing a cross-sectional view of an electrospinning composite nozzle according to an embodiment of the present invention.
2 is a view showing the structure of an electrospinning apparatus according to an embodiment of the present invention.
3 and 4 are cross-sectional views of nanofiber structures of the present invention according to various examples.
5 is a view showing a cross-sectional view of the polymer nanorods according to an embodiment of the present invention.
Figure 6 shows a fluorescence micrograph of the nanofiber structure prepared in Example 1.
7 shows fluorescence micrographs of the polymer nanorods prepared in Example 13. FIG.
8 is a graph showing the change in the length of the polymer nano bar according to the dissolution rate of the solution for the core nanofibers.
9 is a graph showing a change in the diameter of the polymer nanorods according to the electrical conductivity of the solution for the core nanofibers.
10 is a graph showing the change in length of the polymer nanorods according to the voltage applied from the voltage applying unit of the electrospinning apparatus.

The present invention is an external nozzle; And it relates to an electrospinning composite nozzle comprising two or more inner nozzles arranged side by side inside the outer nozzle.

Hereinafter, the electrospinning composite nozzle of the present invention will be described in detail.

1 is a view showing a cross-sectional view of an electrospinning composite nozzle according to an embodiment of the present invention. As shown in FIG. 1, the electrospinning composite nozzle 10 of the present invention comprises: an outer nozzle 1; And two inner nozzles 2 and 3 arranged side by side in the outer nozzle. In FIG. 1, two internal nozzles are arranged side by side inside the external nozzle, but the number of the internal nozzles is not limited thereto, and three or more internal nozzles may be arranged side by side inside the external nozzle. There may be.

In the electrospinning composite nozzle of the present invention, the number of inner nozzles arranged side by side inside the outer nozzle is appropriately adjusted to two or more according to the number of components included in the core nanofibers of the nanofiber structure, which will be described later. Can be. That is, the number of internal nozzles may be adjusted to correspond to the number of components included in the core nanofibers of the nanofiber structure to be described later.

In the electrospinning composite nozzle of the present invention, the sum of the outer diameters of the two or more inner nozzles may be equal to or smaller than the inner diameter of the outer nozzles. In the present invention, regardless of the number of inner nozzles, the sum of the outer diameters of all inner nozzles must be equal to or smaller than the inner diameter of one outer nozzle so that all inner nozzles can be arranged side by side inside the outer nozzle.

In addition, in the electrospinning composite nozzle of the present invention, the outer diameter and the inner diameter of the inner nozzle may be 0.002 mm to 80 mm and 0.001 mm to 30 mm, respectively. If the inner diameter of the inner nozzle is less than 0.002 mm, it is difficult to constantly adjust the flow of the solution for the inner nozzle, it is impossible to produce a nanofiber structure of a constant size, if it exceeds 80 mm, it is discontinuous by a very large surface tension It cannot induce core nanofibers. In addition, when the inner diameter of the inner nozzle is less than 0.001 mm, it is difficult to constantly adjust the flow of the solution for the inner nozzle, and when it exceeds 30 mm, the voltage band for electrospinning becomes high and practically no electrospinning is possible.

In the electrospinning composite nozzle of the present invention, the outer and inner diameters of the outer nozzle may be 0.005 mm to 300 mm and 0.004 mm to 200 mm, respectively. If the outer diameter of the outer nozzle is less than 0.005 mm, it may be difficult to fix two or more inner nozzles, and if it exceeds 300 mm, it may be difficult to actually electrospin. In addition, when the inner diameter of the outer nozzle is less than 0.004 mm or exceeds 200 mm, it may be difficult to control the flow of the solution for the inner nozzle.

In addition, in the electrospinning composite nozzle of the present invention, the axes of the inner nozzles arranged side by side may be on the same line as the axes of the outer nozzles.

In the electrospinning composite nozzle of the present invention, the material of the outer nozzle and the inner nozzle is not particularly limited, and materials generally used in this field may be used without limitation. In the present invention, as the material of the outer nozzle and the inner nozzle, preferably from the group consisting of steel, stainless steel, copper, gold, silver, silicone rubber, polytetrafluoroethylene (PTFE, Polytetrafluoroethylene), polypropylene and polyethylene One or more may be selected, but is not limited thereto.

The present invention also provides a solution supply unit for storing and supplying the solution for the external nozzle and the solution for the two or more internal nozzle; A composite nozzle comprising at least one electrospinning composite nozzle according to the present invention connected to the solution supply for spinning the solution for the external nozzle and the solution for the two or more internal nozzles stored in the solution supply to produce a nanofiber structure part; A collecting unit for collecting the nanofiber structure radiated from the composite nozzle unit; And the collecting part and the composite nozzle part for charging the external nozzle solution and two or more internal nozzle solutions. Or it relates to an electrospinning apparatus comprising a voltage applying unit electrically connected to the collecting unit and the solution supply unit.

In the present specification, the external nozzle solution may be used in the same sense as the cis nanofiber solution described below, and the internal nozzle solution may be used in the same meaning as the core nanofiber solution described below.

2 is a view showing the structure of the electrospinning apparatus according to an embodiment of the present invention. As shown in FIG. 2, the electrospinning apparatus of the present invention includes a solution supply unit 20 for storing and supplying a solution 23 for an external nozzle and a solution 21 and 22 for two internal nozzles; Is connected to the solution supply unit 20 to produce a nanofiber structure 30 by spinning the solution for the external nozzle 23 and the two solution for the inner nozzle 21, 22 stored in the solution supply unit 20 Compound nozzle unit 10 consisting of one electrospinning compound nozzle 10 according to the present invention; A collecting part 40 for collecting the nanofiber structure 30 emitted from the composite nozzle part 10; And connected to the collection part 40 and the solution supply part 20 by electric wires 50a and 50b to charge the external nozzle solution 23 and the two internal nozzle solutions 21 and 22. It may be a structure including a voltage applying unit 50.

In FIG. 2, the internal nozzle solutions 21 and 22 stored in the solution supply unit 20 are shown as two, but the number of the internal nozzle solutions is not limited thereto, and the core of the nanofiber structure to be described later ( core) can be appropriately adjusted to two or more according to the number of components contained in the nanofibers. That is, the number of solutions for the internal nozzle may be adjusted to correspond to the number of components included in the core nanofibers of the nanofiber structure to be described later.

In addition, as shown in FIG. 2, the composite nozzle 10 may use the electrospinning composite nozzle according to the present invention as described above, and the composite nozzle 10 may include an external nozzle 1 and an internal nozzle 2. , 3), and the inner nozzles 2 and 3 are shown as two, but the number of the inner nozzles is not limited thereto, and the number of the components included in the core nanofibers of the nanofiber structure to be described later. It can be suitably adjusted to two or more depending on the number. That is, the number of internal nozzles may be adjusted to correspond to the number of components included in the core nanofibers of the nanofiber structure to be described later. In addition, although the number of the composite nozzles constituting the composite nozzle unit 10 is illustrated as one in FIG. 2, the present invention is not limited thereto, and the composite nozzle unit 10 may include two composite nozzles according to the present invention. May contain more than.

As shown in FIG. 2, in the electrospinning apparatus of the present invention, the solution 23 for the external nozzle of the solution supply unit 20 and the solutions 21 and 22 for the two or more internal nozzles are separated from the supply line 21a, 22a and 23a may be independently connected to the external nozzle 1 and the two or more internal nozzles 2 and 3 of the composite nozzle unit 10, respectively.

In addition, as shown in FIG. 2, in the electrospinning apparatus of the present invention, each of the supply lines 21a, 22a, 23a connecting the solution supply unit 20 and the composite nozzle unit 10 is a transfer pump 21b. 22b and 23b may be additionally installed. The transfer pump may serve to adjust the dissolution rate to supply the solution for the external nozzle and the solution for the two or more internal nozzles at a constant dissolution rate from the solution supply portion to the composite nozzle portion.

In the electrospinning apparatus of the present invention, the solution supply part may supply the solution for the external nozzle at an elution rate of 0.01 mL / h to 500 mL / h, preferably 0.01 mL / h to 50 mL / h, and for two or more internal nozzles. The solution can be fed at an elution rate of 0.01 mL / h to 500 mL / h, preferably 0.01 mL / h to 10 mL / h. The unit of dissolution rate at this time may also be used as the pressure and volume unit. If the dissolution rate of the solution for the external nozzle is less than 0.01 ml / h, electrospinning is not possible, if it exceeds 500 ml / h, it is difficult to produce a nanofiber structure having a uniform thickness. In addition, when the dissolution rate of the solution for the internal nozzle exceeds 500 ml / h, it is difficult to produce a nanofiber structure having an unstable electrospinning uniform thickness.

In the electrospinning apparatus of the present invention, the solution supply portion; Alternatively, the composite nozzle unit may further include a conductor plate (not shown) electrically connected to the voltage applying unit. The conductor plate may serve to apply a high voltage to the external nozzle solution and the two or more internal nozzle solutions in the solution supply unit or the composite nozzle unit.

In the electrospinning apparatus of the present invention, the collecting part serves to collect the nanofiber structure radiated from the composite nozzle part, and may be a fixed flat body or a rotating body that rotates continuously. In FIG. 2, the collecting unit is illustrated as a fixed flat body, but is not limited thereto. Preferably, the collecting unit may be a rotating body that rotates continuously. When the collecting unit is a rotating body that rotates continuously, the nanofiber structure radiated from the composite nozzle unit may be uniformly collected.

In the electrospinning apparatus of the present invention, the distance between the lower end and the collecting portion of the composite nozzle portion may be 0.1 cm to 500 cm, preferably 1 cm to 100 cm, more preferably 5 cm to 30 cm, but is not limited thereto. . If the distance between the lower end and the collecting portion of the composite nozzle portion is less than 0.1 cm, the solidification is not made, the nanofiber structure can not be produced, if it exceeds 500 cm, the applied voltage is increased to cause a decrease in productivity.

In the electrospinning apparatus of the present invention, the voltage applying unit may be electrically connected to the collecting unit and the composite nozzle unit (not shown), or may be electrically connected to the collecting unit and the solution supply unit. The voltage applying unit includes the collecting unit and the composite nozzle unit; Or by being electrically connected to the collecting part and the solution supply part, applying a high voltage to the solution supply part; Or it may serve to charge the solution for the external nozzle and the solution for the two or more internal nozzle in the composite nozzle.

In the electrospinning apparatus of the present invention, the electric field applied is expressed as an applied voltage per unit distance, 0.01 kV to 100 kV per unit distance (cm), preferably 0.01 kV to 50 kV, more preferably An applied voltage of 1 kV to 20 kV can be applied. If the applied voltage per unit distance (cm) is less than 0.01 kV, full emission cannot be performed, and if it exceeds 100 kV, discharge may occur and a fire may occur.

The present invention also relates to core nanofibers in which two or more components are formed in a discontinuous, crossed or non-crossed state; And a sheath nanofiber surrounding the core nanofiber.

3 is a cross-sectional view of a nanofiber structure according to an embodiment of the present invention. As shown in FIG. 3, the nanofiber structure 100 of the present invention includes a core nanofiber 110 in which two components 111 and 112 are discontinuously formed in an intersection; And the sheath nanofibers 120 surrounding the core nanofibers 110. In FIG. 3, the core nanofibers are shown as two components discontinuously formed at the intersection, but the present invention is not limited thereto, and three or more components may be discontinuously formed at the intersection.

4 is a view showing a cross-sectional view of the nanofiber structure according to another embodiment of the present invention. As shown in FIG. 4, the nanofiber structure 200 of the present invention includes a core nanofiber 110 having two components 111 and 112 discontinuously formed; And the sheath nanofibers 120 surrounding the core nanofibers 110. In FIG. 4, the core nanofibers are shown as two components are formed discontinuously, but not limited thereto, and three or more components may be formed discontinuously.

In the nanofiber structure of the present invention, at least one of the two or more components forming the core nanofibers may be a component that is not mixed with the component forming the sheath nanofibers. In the present invention, at least one component of the two or more components forming the core nanofibers is not mixed with the components forming the sheath nanofibers, so that the polymer nanorods composed of one or more components in the production of the nanorods of the present invention described below To allow the manufacture of The nanorod of the present invention and a method of manufacturing the same will be described later.

In the nanofiber structure of the present invention, the number of components forming the sheath nanofibers is not particularly limited, but may preferably be a single component.

In the nanofiber structure of the present invention, the two or more components that form the core nanofibers and the components that form the sheath nanofibers may each independently be a polymeric material.

The type of the polymer material in the present invention is not particularly limited, and may be appropriately selected according to the use of the nanofiber structure, and preferably, polyvinyl polymer, fluorine polymer, polyamide polymer, polyimide polymer, polyethylene, It may be at least one selected from the group consisting of polypropylene, polyethylene oxide, biodegradable polymer and polysaccharide system.

In the present invention, the polyvinyl polymer may be polystyrene, polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone, polypyrrolidone, polypyrrolidone, or polypyrrolidone. Vinyl pyridine or polyethylene terephthalate; The fluorine-based polymer may be polyvinylidene fluoride (PVDF, polyvinylidene fluoride), polyvinyl fluoride (PVF, polyvinyl fluoride), polytetrafluoroethylene (PTFE, polytetrafluoro ethylene), polyhexafluoropropylene (PHFP, polyhexafluoro propylene) ), Polychlorotrifluoroethylene (PCTFE, polychlorotrifluoro ethylene), polytrifluoroethylene, polyhexafluoroisobutylene, polyperfluoro butylethylene, polyperfluoro methyl vinyl ether (PPMVE, polyperfluoro (methylvinylether) ), Polyperfluoro ethyl vinyl ether (PPEVE, polyperfluoro (ethylvinylether)), polyperfluoro propyl vinyl ether (PPPVE, polyperfluoro (propylvinylether), polyperfluoro-2,2-dimethyl-1,3-dioxol (PPDD) or polyperfluoro-2-methylene-4-methyl-1,3-dioxolane (PPMD), etc. The polyamide-based polymer is an aliphatic poly such as nylon. And aromatic polyamides or polyurethanes such as amide, Kevlar, and nomex, and the like, and the polyimide-based polymers include Belspell R (DuPont, Inc.). )), TI polymer (Toray Corporation), New-TPI (Mitsuido Chemical Co., Ltd.), Kelimide and Quenell (Tsubagai Chemical Co., Ltd.), BT Resin (Mitsubishi Chemical Co., Ltd.) , Tolon (Amoco Co., Ltd.) or Uffimol (Eco-Fung Sansa Co., Ltd.), but is not limited thereto.

In the present invention, the biodegradable polymer is polyglycolic acid (PGA, polyglycolic acid), poly-L-lactic acid (PLLA, poly-L-lactic acid), poly-D, L-lactic acid (PDLLA, poly-D, L -lactic acid), polylactic-co-glycolic acid (PLGA), poly-ε-caprolactone (PCL, poly-ε-carprolactone), polyamino acid, polyanhydride ), Polyorthoesters and copolymers thereof, but may not be limited thereto.

In the nanofiber structure of the present invention, the hydrophilic properties of two or more components forming the core nanofibers can be variously adjusted according to the kind of the polymer material to be used. In the present invention, for example, hydrophilic / hydrophilic, hydrophobic / hydrophobic or hydrophilic / hydrophobic core nanofibers can be produced. In particular, the polymer nano of the present invention to be described later by configuring at least one component of the two or more components forming the core nanofibers included in the nanofiber structure with a hydrophilic polymer material and at least another component with a hydrophobic polymer material When the rod is manufactured, the polymer nanorods may have amphipathicity.

The present invention also comprises the steps of preparing a solution for the sheath nanofibers and a solution for at least two core nanofibers; And electrospinning the prepared solution for the sheath nanofibers and the solution for the core nanofibers.

First, in order to manufacture the nanofiber structure according to the present invention, a step of preparing a solution for the sheath nanofibers and a solution for two or more core nanofibers may be performed.

The sheath nanofiber solution and two or more core nanofiber solutions may be prepared by mixing a polymer material and a solvent capable of dissolving the polymer material, respectively. Specific contents of the polymer material are the same as described above.

In the present invention, water or an organic solvent may be used as the solvent for dissolving the polymer material. When the polymer material is a hydrophilic polymer material, water or a hydrophilic organic solvent may be used as a solvent, and in the case of hydrophobic polymer material, a hydrophobic organic solvent may be used.

The type of the material that can be used as the organic solvent in the present invention is not particularly limited, but is preferably dimethylene fluoride, tetramethylene fluoride, anisol, benzyl aldehyde, ethyl acetate , Acetone, acetonitrile, acetaldehyde, acetic acid, acetophenone, acetyl chloride, acrylonitrile, aniline, benzyl alcohol, 1-butanol, n-butyl acetate, cyclohexanol, cyclohexanone ( cyclohexanone), 1,2-dibromo ethane, diethyl ketone, N, N-dimethylacetamide, N, N-dimethylformamide, dimethylsulfoxide, 1,4-dioxane, ethanol, ethyl formate , Formic acid, glycerol, hexamethyl phosphamide, methyl acetate, methyl ethyl ketone, methyl isobutyl ketone, N-methyl-2-pyrrolidone, nitro benzene, nitro methane, 1- At least one selected from the group consisting of ropanol, propylene-1,2-carbonate, tetrahydrofuran, tetramethylurea, triethyl phosphate, trimethyl phosphate, ethylene diamine, N-methylmorpholine N-oxide (NMMO) and mixtures thereof Can be mentioned. In particular, when two or more substances are mixed and used as the organic solvent, two or more hydrophilic organic solvents; Or two or more hydrophobic organic solvents can be mixed and used.

In the nanofiber structure of the present invention, two or more core nanofiber solutions may each be a mixture of a polymer material and a solvent for dissolving the polymer material, wherein the mixture is 0.001% to 80% by weight of the polymer material. , Preferably it may include from 0.01% by weight to 10% by weight, but is not limited thereto. If the content of the polymer is less than 0.001% by weight, the concentration of the polymer is too low to produce a nanofiber structure, if it exceeds 80% by weight, it is difficult to produce a core nanofibers having a uniform diameter. Specific description of the polymer material and the solvent is the same as described above.

In the nanofiber structure of the present invention, the solution for the cis nanofiber may be a mixture consisting of a polymer material and a solvent for dissolving the polymer material, wherein the mixture is 0.1% to 80% by weight, preferably 10 It may be included in the weight percent to 25% by weight, but is not limited thereto. When the content of the polymer is less than 0.1% by weight, it may be prepared in the form of particles, not in the form of fibers, and when it exceeds 80% by weight, electrospinning may be unstable. Specific description of the polymer material and the solvent is the same as described above.

When the polymer material used in the preparation of the solution for the sheath nanofiber solution and at least two core nanofiber solutions is a hydrophilic polymer material, water or a hydrophilic organic solvent capable of dissolving the hydrophilic polymer material may be used as a solvent. In the case of a hydrophobic polymer, a hydrophobic organic solvent capable of dissolving the hydrophobic polymer may be used as the solvent.

In the method for producing a nanofiber structure according to the present invention, at least one solution for the core nanofibers of the two or more solution for the core nanofibers may not be mixed with the solution for the sheath nanofibers. In the present invention, for example, when the solution for the cis nanofibers is a hydrophobic solution, at least one solution for the core nanofibers of the two or more core nanofibers solution may be a hydrophilic solution, the solution for the cis nanofibers is hydrophilic In the case of a solution, at least one solution for core nanofibers of the two or more solution for core nanofibers may be a hydrophobic solution.

In the method for producing a nanofiber structure according to the present invention, at least one of the core nanofiber solution of the two or more core nanofiber solution is not mixed with the solution for the sheath nanofiber, thereby preparing the polymer nanorod of the present invention At the same time, it is possible to manufacture a polymer nanorod consisting of one or more components.

In addition, in the method for producing a nanofiber structure according to the present invention, at least one core nanofiber solution of the at least two core nanofiber solution comprises a hydrophilic polymer material, at least one other solution for the core nanofiber is hydrophobic It may comprise a polymeric material. At least one core nanofiber solution of the two or more core nanofiber solutions includes a hydrophilic polymer material, and the at least one solution for core nanofibers includes a hydrophobic polymer material. At the time of manufacture, the polymer nanorods may have amphipathicity.

The method for producing a nanofiber structure according to the present invention includes the step of electrospinning the prepared solution for the sheath nanofiber and two or more core nanofiber solution.

In the method of manufacturing a nanofiber structure according to the present invention, the step of electrospinning may be performed using the electrospinning apparatus according to the present invention described above. The details of the electrospinning apparatus are the same as described above.

Specifically, the prepared sheath nanofiber solution and two or more core nanofiber solutions, that is, the external nozzle solution 23 and the two or more internal nozzle solutions 21 and 22 are shown in FIG. It can be stored in the solution supply unit 20 and simultaneously supplied to the external nozzle 1 and the two or more internal nozzles 2 and 3 of the composite nozzle unit 10 through separate supply lines 21a, 22a and 23a, respectively. have. In this case, the external nozzle solution 23 and the two or more internal nozzle solutions 21 and 22 may transfer feed pumps 21b, 22b, and 23b which are additionally installed in the respective supply lines 21a, 22a, and 23a. Can be supplied at a constant dissolution rate.

In the method for producing a nanofiber structure according to the present invention, the dissolution rate of the solution for the outer nozzle and the solution for the inner nozzle is not particularly limited, but preferably the dissolution rate of the solution for the outer nozzle is 0.01 ml / h to 500 ml /. h, preferably 0.01 ml / h to 50 ml / h, and the dissolution rate of the solution for two or more internal nozzles may be 0.01 ml / h to 500 ml / h and 0.01 ml / h to 10 ml / h. . If the dissolution rate of the solution for the external nozzle is less than 0.01 ml / h, electrospinning is not possible, if it exceeds 500 ml / h, it is difficult to produce a nanofiber structure having a uniform thickness. In addition, when the dissolution rate of the solution for the internal nozzle exceeds 500 ml / h, it is difficult to produce a nanofiber structure having an unstable electrospinning uniform thickness.

In the method of manufacturing a nanofiber structure according to the present invention, the solution for the external nozzle and the solution for the two or more internal nozzles transferred to the composite nozzle portion may be simultaneously electrospun through the composite nozzle portion. When electrospinning the solutions using the composite nozzle unit according to the present invention included in the electrospinning apparatus described above, according to the pulsating electrospray principle, the solutions for the two or more internal nozzles are radiated alternately or not. It can be spun continuously, the solution for the outer nozzle can be spun continuously while surrounding the solution for two or more inner nozzle. The solution for the external nozzle and the solution for the two or more internal nozzles may be electrospun through the composite nozzle unit, as shown in FIGS. 3 and 4, to form a nanofiber structure according to an embodiment of the present invention. .

When the solution for the two or more inner nozzles are discontinuously and alternately radiated, a nanofiber structure as shown in FIG. 3 may be formed. When the solution for the two or more inner nozzles is discontinuously and randomly radiated, The nanofiber structure as shown in FIG. 4 can be formed.

The prepared nanofiber structure of the present invention may be collected in the collecting portion of the electrospinning apparatus of the present invention.

In the method of manufacturing a nanofiber structure according to the present invention, the distance between the lower end and the collecting portion of the composite nozzle portion may be 0.1 cm to 500 cm, preferably 1 cm to 100 cm, more preferably 5 cm to 30 cm, It is not limited to this. If the distance between the lower end and the collecting portion of the composite nozzle portion is less than 0.1 cm, the solidification is not made, the nanofiber structure can not be produced, if it exceeds 500 cm, the applied voltage can be increased to cause a decrease in productivity. .

In the method of manufacturing a nanofiber structure according to the present invention, in order for the solution for the external nozzle and the solution for the two or more internal nozzles to be electrospun through the composite nozzle portion, it is electrically connected to the collection portion and the composite nozzle portion, or the collection A high voltage must be applied through the part and a voltage applying part electrically connected to the solution supply part. The voltage applying unit may apply an applied voltage of 0.01 kV to 100 kV, preferably 0.01 kV to 50 kV, and more preferably 1 kV to 20 kV per unit distance (cm). If the applied voltage per unit distance (cm) is less than 0.01 kV, electrospinning is not possible, and if it exceeds 100 kV, there is a risk that a discharge occurs and a fire occurs.

The nanofiber structure prepared according to the method of manufacturing a nanofiber structure according to the present invention may serve as a precursor for producing a polymer nanorod to be described later.

The invention also relates to polymeric nanorods containing one or more polymeric materials.

The polymer nanorod of the present invention includes at least one polymer material, and the details of the polymer material are the same as described above.

The polymer nanorods of the present invention may have a diameter of 1 nm to 2,000 nm, preferably 10 nm to 1,000 nm. If the diameter is less than 1 nm or more than 2,000 nm, polymer nanorods may not be formed.

The polymer nanorods of the present invention may have a length of 10 nm to 100,000 nm, preferably 100 nm to 30,000 nm, more preferably 100 nm to 1,000 nm. If the length is less than 10 nm or more than 100,000 nm, polymer nanorods cannot be formed.

The polymer nanorods of the present invention may include a hydrophilic polymer material and a hydrophobic polymer material. When the polymer nanorods of the present invention include a hydrophilic polymer material and a hydrophobic polymer material, they may have amphipathic properties.

5 is a cross-sectional view of the polymer nanorods according to the exemplary embodiment of the present invention. As shown in FIG. 5, the polymer nanorods 300 of the present invention may have a structure including a hydrophilic polymer block 310 and a hydrophobic polymer block 320. In FIG. 5, only one hydrophilic polymer block and one hydrophobic polymer block are shown, but the present invention is not limited thereto, and the polymer nanorods may include two or more hydrophilic polymer blocks and two or more hydrophobic polymer blocks. .

The present invention also relates to a method for producing a polymer nanorod according to the present invention, comprising the step of selectively removing only the sheath nanofibers of the nanofiber structure produced by the method for producing a nanofiber structure according to the present invention described above. will be.

In the method for producing the polymer nanorod of the present invention, the nanofiber structure prepared by the method for producing the nanofiber structure of the present invention described above can be used as a precursor for producing the polymer nanorod.

Specifically, the polymer nanorod of the present invention can be produced by selectively removing only the sheath nanofibers of the nanofiber structure produced by the method for producing a nanofiber structure of the present invention described above.

The nanofiber structure produced by the method for producing a nanofiber structure of the present invention described above comprises: core nanofibers in which at least two components are formed in a discontinuous and intersected or uncrossed state; And sheath nanofibers surrounding the core nanofibers. Therefore, if only the sheath nanofibers of the nanofiber structure are selectively removed, only core nanofibers that are discontinuously formed may remain.

In the present invention, when the core nanofibers of the nanofiber structure contains two or more components that are discontinuously formed, that is, the sheath nanofibers of the nanofiber structure are attached in the case of FIGS. It can be prepared according to the polymer nanorods.

In the method for producing the polymer nanorods of the present invention, the step of selectively removing only the sheath nanofibers of the nanofiber structure, the nanofiber structure is placed in a centrifuge containing a solvent capable of selectively dissolving only the sheath nanofibers, By centrifugation.

When the nanofiber structure according to the present invention is placed in a centrifuge containing a solvent capable of selectively dissolving only the sheath nanofibers of the nanofiber structure, only the sheath nanofibers are dissolved, and the core nanofibers of the nanofiber structure are precipitated. When the centrifuge is rotated at high speed, only the core nanofibers can be extracted into the precipitate. In this case, as shown in FIGS. 3 and 4 to which the core nanofibers are attached, since two or more components are formed discontinuously, the polymer nanorods may be manufactured only by selectively removing the sheath nanofibers.

In the manufacturing method of the polymer nanorod of the present invention, when centrifugation is performed to selectively remove only the sheath nanofibers of the nanofiber structure, the rotational speed of the centrifuge is not particularly limited, but preferably 100 rpm to 500,000 rpm, more preferably 1,000 rpm to 200,000 rpm. If the rotational speed of the centrifuge is less than 100 rpm, the polymer nanorods may not be precipitated, and if it exceeds 200,000 rpm, it may cause the production cost to rise.

In the manufacturing method of the polymer nanorod of the present invention, when centrifugation is performed to selectively remove only the sheath nanofibers of the nanofiber structure, the step of washing the precipitate obtained through centrifugation may be further performed. By washing the precipitate obtained through centrifugation, impurities and solvent remaining in the precipitate can be removed.

The washing of the precipitate may be performed by washing the precipitate using a washing solution. As the washing solution, a solvent in which only the sheath nanofibers are selectively dissolved may be used, and may be repeatedly performed until all impurities and solvents are removed.

According to the manufacturing method of the polymer nanorod of the present invention, the length and diameter of the polymer nanorod can be easily adjusted through various conditions. In the present invention, the discontinuous length and diameter of the core nanofibers may be changed by changing the dissolution rate of the core nanofiber solution, the conductivity of the core nanofiber solution, or the applied voltage. As a result, the length and diameter of the polymer nanorods can be variously adjusted.

[ Example ]

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the scope of the present invention is not limited by the following examples.

<Production of Nano Fiber Structure>

Example  One

Sheath  Preparation of solutions for nanofibers

A solution for cis nanofibers was prepared by dissolving polystyrene as a hydrophobic polymer in an organic solvent mixed with benzyl aldehyde and ethyl acetate in a 1: 1 (volume ratio). The content of polystyrene contained in the sheath nanofiber solution was 15% by weight.

Preparation of Solution for Core Nanofibers

A solution for the first core nanofiber was prepared by dissolving polyvinyl alcohol, a hydrophilic polymer, in water, and a solution for the second core nanofiber, by dissolving polyvinylidenefluoride, a hydrophobic polymer, in dimethylformamide. Prepared. The content of the polyvinyl alcohol contained in the solution for the first core nanofibers was 5% by weight, and the content of the polyvinylidene fluoride contained in the solution for the second core nanofibers was 5% by weight, and the first core The electrical conductivity of the solution for nanofibers and the solution for second core nanofibers was 0.04 μS / cm.

Fabrication of Nanofiber Structures Using Electrospinning Apparatus

The nano-structure of the structure as shown in Figure 3 attached to the electrospinning using the electrospinning apparatus according to the present invention shown in Figure 2 attached to the prepared solution for the sheath nanofibers and the core nanofibers A fiber structure was prepared, wherein the prepared nanofiber structure comprises: core nanofibers in which a plurality of blocks in which polyvinyl alcohol and polyvinylidene fluoride are formed in a discontinuous manner are formed; And a sheath nanofiber surrounding the core nanofiber and formed of polystyrene.

Looking at the manufacturing process of the nanofiber structure using the electrospinning apparatus in detail, the prepared solution for the sheath nanofiber and two core nanofiber solution is stored in the solution supply unit, each solution is a composite nozzle through the supply line The negative external nozzle and the two internal nozzles were supplied. The outer nozzle and the two inner nozzles of the composite nozzle part were made of stainless steel, and the outer and inner diameters of the outer nozzle were 0.7 mm and 0.05 mm, respectively, and the outer and inner diameters of the inner nozzle were 0.02 mm and 0.015 mm, respectively.

The solution for the sheath nanofibers was maintained at a dissolution rate of 5 ml / h through a transfer pump installed in a supply line, and the two core nanofiber solutions were each prepared at a dissolution rate of 0.1 by a transfer pump installed in a supply line. Kept at ml / h. In addition, a voltage of 9.5 kV was applied through a voltage applying part electrically connected to the solution supply part and the collecting part to charge the sheath nanofiber solution and the solution for the two core nanofibers, which were radiated through the composite nozzle part. The nanofiber structure having the structure as shown in FIG. 3 was collected at the collecting portion. At this time, the distance from the lowest end of the composite nozzle portion to the collecting portion was 20 cm.

Example  2 to 5

In the preparation of the nanofiber structure using the electrospinning apparatus, the dissolution rate of the solution for the core nanofibers was 0.2 ml / h (Example 2), 0.3 ml / h (Example 3), 0.4 ml / h (Example 4 ) And 0.5 ml / h (Example 5) except that the nanofiber structure was prepared in the same manner as in Example 1.

Example  6 to 8

In the preparation of the solution for the core nanofibers, in the preparation of the solution for the first core nanofibers and the solution for the second core nanofibers, sodium chloride solution was added, respectively, so that the electrical conductivity was 50 μS / cm (Example 6), 150 μS / A nanofiber structure was prepared in the same manner as in Example 1 except for changing to cm (Example 7) and 270 μS / cm (Example 8).

Example  9-12

In the fabrication process of the nanofiber structure using the electrospinning apparatus, the applied voltage was changed to 11.5 kV (Example 9), 13.5 kV (Example 10), 15.5 kV (Example 11), and 17.5 kV (Example 12). A nanofiber structure was prepared in the same manner as in Example 1 except that.

<Production of Polymer Nanorods>

Example  13

The nanofiber structure prepared in Example 1 was placed in a centrifuge containing 5% by weight of benzylaldehyde solution, and the centrifuge was rotated at 10,000 rpm to obtain a precipitate. In the nanofiber structure prepared in Example 1, cis nanofibers formed of polystyrene were dissolved in benzylaldehyde solution, and core nanofibers formed of polyvinyl alcohol and polyvinylidenefluoride were benzylaldehyde solution. It did not dissolve in and remained a precipitate. That is, only the cis nanofibers of the nanofiber structure were selectively removed through the benzylaldehyde solution.

The precipitate obtained through the centrifugation was washed several times with benzylaldehyde as a washing solution to obtain a polymer nanorod consisting of a polyvinyl alcohol block and a polyvinylidene fluoride block.

Example  14 to 24

Polymer nanorods were prepared in the same manner as in Example 13, except that the nanofiber structures prepared in Examples 2 to 12 were used instead of the nanofiber structures prepared in Example 1.

The preparation conditions of the nanofiber structures prepared in Examples 1 to 12 are summarized in Table 1 below.

Example Manufacturing Conditions of Nanofiber Structures Nano fiber structure Polymer
Nano rod Core of nanofiber
Elution rate (ml / h) Core of nanofiber
Electrical Conductivity (μS / cm ) Applied voltage ( kV ) Example  One Example  13 0.1 ml / h 0.04 μS / cm 9.5 kV Example  2 Example  14 0.2 ml / h 0.04 μS / cm 9.5 kV Example  3 Example  15 0.3 ml / h 0.04 μS / cm 9.5 kV Example  4 Example  16 0.4 ml / h 0.04 μS / cm 9.5 kV Example  5 Example  17 0.5 ml / h 0.04 μS / cm 9.5 kV Example  6 Example  18 0.1 ml / h 50 μS / cm 9.5 kV Example  7 Example  19 0.1 ml / h 150 μS / cm 9.5 kV Example  8 Example  20 0.1 ml / h 270 μS / cm 9.5 kV Example  9 Example  21 0.1 ml / h 0.04 μS / cm 11.5 kV Example  10 Example  22 0.1 ml / h 0.04 μS / cm 13.5 kV Example  11 Example  23 0.1 ml / h 0.04 μS / cm 15.5 kV Example  12 Example  24 0.1 ml / h 0.04 μS / cm 17.5 kV

Test Example  One

In order to confirm the presence of the nanofiber structure prepared in Example 1 and the polymer nanorods prepared in Example 13, it was observed using a fluorescence microscope. 6 shows a fluorescence micrograph of the nanofiber structure prepared in Example 1, and FIG. 7 shows a fluorescence micrograph of the polymer nanorods prepared in Example 13. FIG. 6, it can be seen that the nanofiber structure prepared in Example 1 has core nanofibers which are discontinuously formed while crossing polyvinyl alcohol and polyvinylidene fluoride. 7, it can be seen that the amphipathic polymer nanorods having polyvinyl alcohol blocks and polyvinylidene fluoride blocks were selectively removed by only removing the sheath nanofibers from the nanofiber structure prepared in Example 14.

Test Example  2

In the manufacturing process of the nanofiber structure using the electrospinning apparatus, in order to determine the change in the length of the polymer nanorods by changing the dissolution rate of the core nanofiber solution, the length of the polymer nanorods prepared in Examples 13 to 17 Was measured using an electron microscope (FE-SEM, manufactured by Carl Zeiss, Germany) and a particle size analyzer (LA-910, manufactured by Horiba, Japan).

8 is a graph showing the length of the polymer nanorods prepared in Examples 13 to 17, and shows that the length of the polymer nanorods increases as the dissolution rate of the solution for the core nanofibers increases. That is, it can be seen that by adjusting the dissolution rate of the solution for the core nanofibers can be easily prepared polymer nanorods of various lengths.

Test Example  3

In the manufacturing process of the nanofiber structure using the electrospinning apparatus, in order to determine the change in the diameter of the polymer nanorods by changing the electrical conductivity of the solution for the core nanofibers, prepared in Examples 13 and 18 to 20 The diameter of the polymer nanorods was measured using an electron microscope (FE-SEM, manufactured by Carl Zeiss, Germany) and a particle size analyzer (LA-910, manufactured by Horiba, Japan).

9 is a graph showing the diameters of the polymer nanorods prepared in Examples 13 and 18 to 20, showing that the diameter of the polymer nanorods increases as the electrical conductivity of the solution for core nanofibers increases. . In other words, it can be seen that by adjusting the electrical conductivity of the solution for the core nanofibers can be easily prepared polymer nanorods of various diameters.

Test Example  4

In the manufacturing process of the nanofiber structure using the electrospinning apparatus, in order to determine the change in the length of the polymer nanorods by changing the voltage applied from the voltage applying unit, the polymer nanoparticles prepared in Examples 13 and 21 to 24 The length of the rod was measured using an electron microscope (FE-SEM, manufactured by Carl Zeiss, Germany) and a particle size analyzer (LA-910, manufactured by Horiba, Japan).

10 is a graph showing the lengths of the polymer nanorods prepared in Examples 13 and 21 to 24, and shows that the lengths of the polymer nanorods generally increase as the applied voltage increases. That is, it can be seen that by adjusting the voltage applied from the voltage applying unit, it is easy to manufacture polymer nanorods of various lengths.

1: outside nozzle 2,3: inside nozzle
10: electrospinning composite nozzle 20: solution supply
21: solution for first internal nozzle 22: solution for second internal nozzle
23: solution for external nozzle 21a, 22a, 23a: supply line
21b, 22b, 23b: transfer pump 40: collecting part
30,100,200: nanofiber structure 50: voltage applying unit
50a, 50b: electric wire 110: core nanofiber
111: first component of the core nanofibers
112: second component of the core nanofibers
120: sheath nanofiber 300: polymer nanorod
310: hydrophilic polymer block 320: hydrophobic polymer block

Claims (28)

External nozzles; And
An electrospinning composite nozzle comprising two or more inner nozzles arranged side by side inside the outer nozzle. The method of claim 1,
Electrospinning composite nozzles wherein the sum of the outer diameters of two or more inner nozzles is equal to or less than the inner diameter of the outer nozzles. The method of claim 2,
An outer diameter and an inner diameter of the inner nozzle is 0.002 mm to 80 mm and 0.001 mm to 30 mm, respectively, the outer diameter and inner diameter of the outer nozzle is 0.005 mm to 300 mm and 0.004 mm to 200 mm, respectively. The method of claim 1,
An electrospinning composite nozzle whose axis of the inner nozzle is flush with the axis of the outer nozzle. The method of claim 1,
The material of the external nozzle and the internal nozzle is at least one electrospinning composite nozzle selected from the group consisting of steel, stainless steel, copper, gold, silver, silicone rubber, polytetrafluoroethylene (PTFE, Polytetrafluoroethylene), polypropylene and polyethylene . A solution supply unit for storing and supplying a solution for an outer nozzle and a solution for two or more inner nozzles;
The electrospinning composite according to any one of claims 1 to 5, wherein the solution for the external nozzle and the solution for the two or more internal nozzles are radiated to produce a nanofiber structure by spinning the solution supply. A composite nozzle unit including at least one nozzle;
A collecting unit for collecting the nanofiber structure radiated from the composite nozzle unit; And
The collection unit and the composite nozzle unit for charging the external nozzle solution and at least two internal nozzle solutions; Or a voltage applying unit electrically connected to the collection unit and the solution supply unit. The method according to claim 6,
An electrospinning apparatus in which the solution for the external nozzle of the solution supply part and the solution for the two or more internal nozzles are independently connected to the external nozzle and the two or more internal nozzles, respectively, through separate supply lines. The method according to claim 6,
An electrospinning apparatus for supplying a solution for the external nozzle at an elution rate of 0.01 mL / h to 500 mL / h, and supplying two or more solutions for the internal nozzle at an elution rate of 0.01 mL / h to 500 mL / h. The method according to claim 6,
Solution supply; Or an electrospinning apparatus further comprising a conductor plate electrically connected to the voltage applying unit in the composite nozzle unit. The method according to claim 6,
The collecting part is an electrospinning apparatus which is a fixed flat body or a rotating body rotating continuously. The method according to claim 6,
An electrospinning apparatus having a distance between the bottom of the composite nozzle portion and the collecting portion of 0.1 cm to 500 cm. The method according to claim 6,
The voltage applying unit is an electrospinning apparatus for applying an applied voltage of 0.01 kV to 100 kV per unit distance (cm). Core nanofibers in which two or more components are formed in a discontinuous and crossed or uncrossed state; And sheath nanofibers surrounding the core nanofibers. The method of claim 13,
At least one component of the two or more components that form the core nanofibers is a component that does not mix with the components that form the sheath nanofibers. The method of claim 13,
Two or more components forming the core nanofibers and the components forming the sheath nanofibers are each independently a nanofiber structure. The method of claim 15,
The polymer material is at least one selected from the group consisting of polyvinyl polymers, fluorine polymers, polyamide polymers, polyimide polymers, polyethylene, polypropylene, polyethylene oxide, biodegradable polymers, and polysaccharides. 17. The method of claim 16,
Biodegradable polymers include polyglycolic acid (PGA), poly-L-lactic acid (PLLA), poly-D, L-lactic acid (PDLLA), Polylactic-co-glycolic acid (PLGA), poly-ε-carprolactone (PCL), polyamino acid, polyanhydride, polyortho At least one nanofiber structure selected from the group consisting of esters and copolymers thereof. The method of claim 13,
At least one component of the two or more components forming the core nanofibers is a hydrophilic polymer material, and at least the other component is a hydrophobic polymer material. Preparing a solution for the sheath nanofibers and a solution for the at least two core nanofibers; And
The method of manufacturing a nanofiber structure according to claim 13, comprising the step of electrospinning the prepared solution for the sheath nanofibers and at least two core nanofibers. The method of claim 19,
At least one of the two or more solutions for the core nanofibers is not mixed with a solution for the sheath nanofibers. The method of claim 19,
Electrospinning step is a method for producing a nanofiber structure is carried out using the electrospinning apparatus according to claim 6. Polymer nanorods containing one or more polymeric materials. 23. The method of claim 22,
Polymeric nanorods having a diameter of 1 nm to 2,000 nm and a length of 10 nm to 100,000 nm. 23. The method of claim 22,
Polymer nanorods containing hydrophilic and hydrophobic polymers. The method for producing the polymer nanorods according to claim 22, comprising selectively removing only the sheath nanofibers of the nanofiber structure produced by the method for producing a nanofiber structure according to claim 19. The method of claim 25,
Selectively removing only the sheath nanofibers, wherein the nanofiber structure is placed in a centrifuge containing a solvent capable of selectively dissolving only the sheath nanofibers and centrifuged. The method of claim 26,
The rotation speed of the centrifuge is 100 rpm to 200,000 rpm manufacturing method of the polymer nanorods. The method of claim 26,
Method for producing a polymer nano-rod further comprising the step of washing the precipitate obtained by centrifugation.

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