KR20120125922A - Method for auto-generating process map in radiopharmaceutical synthesis - Google Patents

Abstract

PURPOSE: An automatic process map generating method is provided to express a configuration diagram of a composition module to remove an error in process map preparation and mathematically generate a transfer path for a solution by Dijkstra's algorithm. CONSTITUTION: The shortest path map capable of transferring a reagent or a radioactive substance between nodes of a network is generated through Dijkstra's algorithm. A process list including information for a chemical reaction and the information for transfer of the reagent and the radioactive substance is inputted(S41). When the information for the transfer exists according to the process list, a process map controlling a valve and a syringe suitable for a moving path generated through the shortest path map is generated(S4). When the information for the chemical reaction exists, the process map controlled holding time and temperature of a furnace is generated.

Description

Method for auto-generating process map in radiopharmaceutical synthesis}

The present invention relates to a method for automatically generating a process map for radiopharmaceutical synthesis.

Radiopharmaceuticals for PET, which are used for disease diagnosis, are produced through the chemical reaction of radioisotopes produced in cyclotrons with various reagents. These radiopharmaceuticals are produced through a series of chemical reactions in reagents and radiosynthetic equipment. The radiopharmaceuticals thus produced are not in stock due to their half-life of about 2 hours and are synthesized several hours before the scheduled PET diagnosis schedule. As it is directly administered to the human body, high purity synthesis is required, and since the raw material reagent is expensive, high yield is required.

However, the synthesis of radiopharmaceuticals has a problem of radioactive exposure, so the use of automatic synthesis equipment is required. In addition to radiochemical expertise, a long experience in the use of automatic synthesis equipment is required. Therefore, in order to develop new drugs and to construct new synthesis modules, it is necessary to optimize parameters for equipment customization, and for this, repetitive experiments are required.

The experiment for the configuration of the synthesis module and the optimization of the parameters may be configured in three steps. First, the synthesis module is composed and the experimental variables are designed to create the synthesis process. Next, the process created through simulation is verified to prevent equipment malfunction and to ensure a faithful chemical reaction. After this verification process, a synthesis experiment is conducted and the results are analyzed. It is very time consuming to create a double synthesis process and to verify it through simulation, which requires the operator to set up design parameters according to the experimental plan and manually create a process for controlling the equipment for chemical reactions. Because.

More specifically, the general structure of the radiopharmaceutical automatic synthesis equipment for PET may be composed of an actuator, a sensor, a control unit and accessories for the flow and control of the solution. In order to control the actuator of such a synthesis equipment, a chemical process is prepared for each stage of synthesis. Unlike the general program, the process is designed to control chemical reactions. It is written with hundreds of lines of control program that instructs the specific operation of each actuator in each row. The process of synthesis parameters (temperature, time, reaction reagent / amount, etc.) The contents change according to the change. However, the preparation of the existing process for the synthesis of radiopharmaceuticals depends much on the method of reducing trial and error through manual preparation and repeated experiments according to the experimenter's experience. In addition, it is difficult to accurately verify the complex process created visually through a graphic simulator.

In other words, it took a lot of time and effort to complete an error-free process through existing methods of writing and verifying.

SUMMARY OF THE INVENTION The present invention was created to solve the problems as described above, and an object of the present invention is to provide a process map automatic generation method in which a process map can be automatically and quickly created.

The process map automatic generation method according to an embodiment of the present invention for achieving the above object is defined as a node for the synthesis module for the synthesis of radiopharmaceutical (node) and the connecting member for connecting the synthesis module (arc) Defining a, by the modeling the synthesis module and the connecting member in the network, generating a shortest path map that the reagent or radioactive material can be transferred between the nodes of the network through a Dijkstra algorithm, Receiving a process list including information for transporting the reagent or radioactive material and information for chemical reactions, and, according to the process list, a transport path generated through the shortest path map if there is information for transport Process maps to control valves and syringes accordingly. When a step of generating a map for controlling the process temperature and the holding time of the reactor.

The generating of the process map may include reading one process from the process list, when the one process has information for the transport, generating the transport path through the shortest path map, and transferring the process. Setting a connection path of a cassette valve according to a path, and when the gas is designated as a transfer method in the one process, the gas connected to the gas supply unit of the designated gas; Setting the valve to an open state, when the one process has information for the transfer, and a syringe is designated as the transfer method in the transfer information, the reagent or the transfer amount specified in the transfer information. Setting an amount of change in the position of the syringe so that radioactive material can be transferred, If there is information for the chemical reaction in the one process, setting the temperature and the holding time of the reactor according to the information for the chemical reaction, and setting the cassette valve, setting the gas valve, The process map may be prepared according to the setting of the syringe and the setting of the reactor.

The generating of the process map may be repeated for the next process of the one process when the one process is not the last process of the process list.

Synthesis module defined as a node of the network is any one of a storage unit for storing the reagent or radioactive material, a transfer unit for transporting the reagent or radioactive material, and a cassette valve for controlling the path to the reagent or radioactive material is transported The connecting member defined as the arc of the network may be a tube through which the reagent or radioactive material flows.

The transfer unit may be any one of a gas supply unit and a syringe for transferring the reagent or radioactive material through the supply of gas.

The generating of the shortest path map may include selecting any arc among the two or more arcs, but preferentially the bidirectional arc when there are two or more arcs connecting the nodes of the network when generating the shortest path map. Can be selected.

The information for transport includes information about a transport path including a departure node and an arrival node, information about a transport method, and information about a transport amount, and the information about the transport path is between the departure node and the arrival node. If there is a node to be passed through the node further includes a diesel node, the information on the transfer method may be any one of the transfer method by gas and the syringe transfer method.

On the other hand, the computer-readable medium according to an embodiment of the present invention may include a program command for performing the process map automatic generation method according to an embodiment of the present invention.

According to the present invention, in order to eliminate the errors in the process map preparation, the composition diagram of the synthesis module is represented by a network, and the transport path of the solution (reagent or radioactive material) is mathematically generated by the Dijkstra algorithm, thereby making it accurate and error-free. Missing process maps can be automatically generated quickly.

1 is a flowchart of a process map automatic generation method according to an embodiment of the present invention.
2 is a diagram illustrating an example of a process map for synthesizing a radiopharmaceutical created through a process map automatic generation method according to an embodiment of the present invention.
3 is a view showing the actual shape of the radiopharmaceutical synthesis module, simplified (simplification), a state and a state expressed in a network.
Figure 4 is a conceptual diagram showing the configuration of the cassette valve and the control command for the cassette valve of the radiopharmaceutical synthesis module.
FIG. 5 is a diagram illustrating a shortest path map between nodes of a network representing a synthesis module of a radiopharmaceutical through a Dijkstra algorithm.
6 is a diagram illustrating an example of a process list input for automatic generation of a process map for synthesizing a radiopharmaceutical.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a flowchart of a process map automatic generation method according to an embodiment of the present invention, Figure 2 is an example of a process map for the synthesis of radiopharmaceuticals prepared through the process map automatic generation method according to an embodiment of the present invention The figure shown.

In general, the process map for the synthesis of radiopharmaceuticals is prepared according to the characteristics of the synthesis equipment. For example, referring to FIG. 2, such a process map may be made up of a combination of items such as parameter setting for chemical reaction, cassette valve and syringe control, adjustment of valve control value according to reagent transfer, and the like.

The present invention recognizes radioactive substances and reagents in the synthesis of radiopharmaceuticals as objects of a network and expresses the composition of the synthesis module as a network, and then radioactive substances or reagents in such a network by a Dijkstra algorithm (Ravindra, 1993). A process map auto-generation method for generating information about the shortest path that can be transported and post-processing the process list for the synthesis of radiopharmaceuticals so that the process map for the above-described synthesis is mathematically created automatically. It is about. Although the present invention may be applied to the generation of a process map for the synthesis of various radiopharmaceuticals, the following description mainly describes the case of synthesis of radiopharmaceuticals for PET.

Referring to Figure 1, the process map automatic generation method according to an embodiment of the present invention (hereinafter referred to as 'the process map automatic generation method') (S100) is a node for the synthesis module for the synthesis of radiopharmaceutical (node) Defining and defining a connection member for connecting the synthesis module as an arc (arc), comprising the step (S1) for modeling the synthesis module and the connection member in the network.

3 is a view showing the actual shape of the radiopharmaceutical synthesis module, simplified (simplification), and a state expressed in a network, Figure 4 is a conceptual diagram showing the configuration of the cassette valve and the control command for the cassette valve of the radiopharmaceutical synthesis module to be.

Referring to FIG. 3, the connecting member defined as the arc of the network may be a tube through which a reagent or a radioactive material flows. In addition, the synthesis module of a radiopharmaceutical may be represented by a node according to a path through which a reagent or a radioactive material flows. The synthesis module defined as a node of such a network may be any one of a storage unit for storing reagents or radioactive materials, a transfer unit for transferring reagents or radioactive materials, and a cassette valve for controlling a path through which the reagents or radioactive materials are transferred. . For example, the storage unit may be represented in the network as a container node, the transfer unit as a manipulator node, and the cassette valve as a control node.

For example, as shown in FIGS. 3A, 4B, and 4, the cassette valve may be a 3-way control valve, and the 3-way control valve may have three input / output points. Referring to FIG. 4, three cassette valves excluding the cassette valves at both ends may be connected to the cassette valves adjacent to the input / output points ① and ③. For example, referring to (a), (b) and 4 of FIG. 3, the input / output point # 2 of the cassette valve includes a reagent bottle, a reservoir, a syringe, a reactor, and a waste container. A storage unit (a container node in the network) capable of storing a solution, such as a bottle, or a connecting member (an arc in the network) for transporting reagents or radioactive materials, such as a tube, may be connected. The control command of each cassette valve may be three as shown in FIG.

In addition, the transfer unit represented by the manipulator node may be any one of a gas supply unit and a syringe that transfer reagents or radioactive materials through supply of gas. However, the syringe is defined as a manipulator node as a transfer unit that enables the transfer of reagents or radioactive materials, but at the same time it can also be viewed as a container node because it also functions as a storage unit for storing reagents or radioactive materials. The gas supply unit represented by the manipulator node may be a method using nitrogen (N 2), compressed air (Air), vacuum (Vac), or the like. In addition, the connection between the container node or the control node and the manipulator node which is the gas supply unit may be represented by an arc as described above. At this time, the two-way valve that can actually control the flow of gas in this arc will be arranged, but in the network such two-way valves are not represented as a separate node, such as a cassette valve. Referring to FIG. 2, this 2-way valve is reflected in an item such as a valve control value (eg, 2-way valve connected Node #) according to reagent transfer in a process map to be prepared.

As an example of the radiopharmaceutical synthesis module configuration for PET represented by the network consisting of the node and the arc as described above, the synthesis module as shown in Figure 3 (a) through a simplified process as shown in Figure 3 (b) Can be modeled with a network model as in c).

Also, referring to FIG. 1, the process map automatic generation method S100 generates a shortest path map through which a reagent or radioactive material can be transferred between nodes of a network through a Dijkstra algorithm (S2). It includes.

For example, the synthesis of a radiopharmaceutical for PET made through the composition of the synthesis module as shown in (a) and (b) of FIG. 3 is a reagent or radioactivity when viewed in a network represented as in (c) of FIG. The material may be made through the repetition of the process of transferring from one container node to another container node. For reference, one solution may be transferred at a time, through which solutions may be mixed and reaction conditions may be activated.

When the weight of all arcs is 1 and the weights between the nodes that are not connected are sufficiently large, the shortest path for transferring the solution from any node i to node j (i ≠ j) is the Dijkstra algorithm described above. algorithm) (Ravindra, 1993). In this case, when there are two or more arcs connecting between nodes of the network, any one of two or more arcs may be selected, but an arc of bidirectionality may be preferentially selected.

FIG. 5 is a diagram illustrating a shortest path map between nodes of a network representing a synthesis module of a radiopharmaceutical through a Dijkstra algorithm.

That is, when a solution moves between nodes in a network as shown in (c) of FIG. 3, referring to FIG. 5, a shortest path map between each node may be obtained through a Dijkstra algorithm. For example, if you want to send reagents from syringe 1 (node 8 in FIG. 3 (c)) to the reactor (node 36 in FIG. 3 (c)), the source node in the shortest path map of FIG. With respect to the in-node 8, the intermediate route nodes 25, 24, 23, 22, and 21 may be sequentially found from the end node 36, which is the sink node, to construct the shortest path.

In addition, referring to Figure 1, the process map automatic generation method (S100) includes a step (S3) of receiving a process list including information for the transport of reagents or radioactive material and information for chemical reactions.

Processes for synthesis may include rules for the transport of reagents or radioactive materials and rules for the activation of chemical reactions. Therefore, in order to automatically generate a process map for synthesis through the process map automatic generation method (S100), as shown in Table 1, information for transporting reagents or radioactive materials and information for chemical reactions need to be input. That is, for the automatic generation of each item of the process map, which may consist of a combination of parameters such as parameter setting for chemical reaction, cassette valve and syringe control, and adjustment of valve control value according to reagent transfer, Information for transport and information for chemical reactions is basically necessary.

Referring to Table 1, information for transport may include information about a transport path including a departure node and an arrival node, information about a transport method, and information about a transport amount. The information about the dual transport path may further include a transit node when there is a node to be transited between the departure node and the arrival node. In addition, the information about the transfer method may be any one of a transfer method by gas and a syringe transfer method. In addition, the information for the chemical reaction may include information on the temperature and holding time of the reactor as shown in Table 1.

By standardizing the synthesis procedure as described above and inputting the process list, a more accurate and error-free process map can be created in step S4 of generating a process map to be described later.

In addition, referring to Figure 1, the process map automatic generation method (S100) according to the process list, if there is information for the transfer generates a process map for controlling the valve and syringe in accordance with the transport path generated through the shortest path map and If there is information for the chemical reaction, a process map for controlling the temperature and the holding time of the reactor includes a step (S4).

In step S4 of generating such a process map, the synthesis module is modeled as a network (S1), a shortest path map between each node in the network is generated (S2), and after receiving a standardized process list (S3). It can also be referred to as a post-processing step in which post-processing for process map automatic generation is performed based on these. That is, this post-processing step (S4) is a process list for the synthesis procedure as shown in Table 1, using the modeled network and the shortest path map, and considering the characteristics of the synthesis module, the process map as shown in Figure 2 automatically It can be said to convert.

Referring to FIG. 1, step S4 of generating a process map may include step S41 of reading one process from a process list.

In the operation of the synthesis module according to the synthesis process of the received process list, first, it is necessary to verify whether the input transport path is the correct transport path capable of transporting the solution. The condition and position of the valve (eg the connection path of the cassette valve) present on the proven solution transport path must then be manipulated and the correct amount of transport controlled. Therefore, after reading one process from the process list (S41), the post-processing step (S4) can be largely composed of three main processes: generation of a solution transfer path, valve control and syringe position control, and reactor heating / cooling. have. That is, process maps may be sequentially created according to the flowchart shown in FIG. 1 in which these three main processes are reflected.

Referring to FIG. 1, in the process of generating a process map (S4), when there is information for transport in one process, the transport path is generated through the shortest path map, and the connection path of the cassette valve is set according to the transport path. It may include the step (S42).

The generation of the transport path may be performed by generating a path through which the reagent or radioactive material flows using the shortest path map generated by the Dijkstra algorithm. Here, the specific configuration of each synthesis module and its connection relationship for the synthesis of radiopharmaceuticals can be seen as set.

And in the valve control and syringe position control, the valve control may be composed of the control of the cassette valve and the control of the valve (such as a 2-way valve mounted on the tube and connected to the gas supply unit). Control of the double cassette valve can be made by selecting a position (connection path) according to a control command as shown in Fig. 4 prior to the generated transfer path.

In addition, referring to FIG. 1, in the step S4 of generating a process map, when a gas is designated as a transfer method in a single process and information is transferred, the gas connected to the gas supply unit of the designated gas It may include the step of setting the valve to the open state (S43).

That is, the control of the valve for the gas supply of the above-described valve control is performed when the method of transferring the solution (reagent or radioactive material) is specified as a gas on the process list, the gas valve (eg 2- way valve) can be set to open. For reference, the gas supply unit may be selected according to the information on the transfer path of the departure node and the like shown in the process list.

In addition, referring to FIG. 1, in the step S4 of generating a process map, when a process has information for transport and a syringe is designated as a transport method in the information for transport, a transport amount specified in the information for transport It may include the step (S44) of setting the position change amount of the syringe so that the reagent or radioactive material as much as possible.

That is, in the above-described valve control and syringe position control, the syringe position control is performed when the method of transferring the solution (reagent or radioactive material) is designated as the syringe on the process list. The position change amount can be achieved by setting. For reference, the syringe may be selected according to the information on the transfer path of the departure node and the like shown in the process list.

In addition, referring to FIG. 1, in the step S4 of generating a process map, when there is information for a chemical reaction in one process, setting a temperature and a holding time of the reactor according to the information for the chemical reaction (S45). ) May be included. By setting the temperature and the holding time of the reactor as described above, a process map can be prepared in which the chemical reaction required for the synthesis of radiopharmaceuticals can be activated by heating or cooling the reactor.

Referring to FIG. 1, the generating of the process map (S4) may include creating the process map according to the setting of the cassette valve, the setting of the gas valve, the setting of the syringe, and the setting of the reactor (S46). .

1, step S4 of generating such a process map may be repeatedly performed for the next process of one process when one process is not the last process of the process list. That is, after the process map is created once according to the above-described setting through the step S4 of reading one process from the process list and generating a process map, the next process is read from the process list and the process map is generated again. The following process map can be created according to step S4. If there is no further process to read from the process list (final step), as shown in FIG. 1, the creation of the process map is completed and the post-processing step S4 may be ended.

Hereinafter, the process of automatically generating a process map through the process map automatic generation method (S100) by receiving a process list regarding the synthesis procedure of [ ¹⁸ F] FD or Fluorodeoxyglucose (FDG) used for tumor diagnosis will be described. For example, see.

For automatic generation of a process map for [18F] FDG synthesis, the network model of FIG. 3 (c) representing the synthesis module of FIG. 3 (a) and (b) and its connection relationship, and Dijkstra to such a network model The shortest path map as shown in FIG. 5 generated by applying the algorithm is used. That is, according to the process map automatic generation method (S100), first, the step S1 of modeling the synthesis module and its connection relationship with the network and the step S2 of generating the shortest path map are performed.

As shown in Table 2, the synthesis procedure of [ ¹⁸ F] FDG can be largely divided into four steps. First i) filter the required portion of the radioactive material ([ ¹⁸ F] in H ₂ ¹⁸ O) produced from cyclotron using a QMA cartridge, and ii) mix and heat acetonitrile (CH ₃ CN) after filtration and radioactive Remove a small amount of water (H ₂ ¹⁸ O) contained in the material. iii) acetyl group was removed using acid (HCl) and neutralized using NaOH. Finally, iv) solvent and organics were filtered using a cartridge called Sep-Pak, and only pure [ ¹⁸ F] FDG was purified. . Each of these steps can be further subdivided into considerations, taking into account the physical and chemical reactions for the synthesis of [ ¹⁸ F] FDG.

For example, the detailed steps of separating and drying [ ¹⁸ F] from the radioactive material (H ₂ ¹⁸ O in M + 18F-) produced in cyclotron (step 1 in Table 2), i) using QMA ¹⁸ F- is eluted, and ii) ¹⁸ F- held in QMA is eluted using an elution reagent. Iii) Acetone nitrile (CH ₃ CN) is then added and heated to remove the small amount of water (water) contained in the radioactive material.

6 is a diagram illustrating an example of a process list input for automatic generation of a process map for synthesizing a radiopharmaceutical.

For example, if only a detailed step of the [ ¹⁸ F] separation and drying step is prepared in the process list, it is as shown in FIG. 6. According to the process map automatic generation method S100, step S3 of receiving such a process list is performed.

This process maps related to this process map is processed (post processing) and then through the step (S4) for generating a process map of an automatic generation method (S100) is created ^[18 F] removing and drying step according to the process list received in this way As shown in FIG. For reference, the cells indicated by thick solid lines in each row of the process map of FIG. 2 indicate a change in driving (state) of the synthesis module and a change in heating / cooling operation (state) of the reactor.

For example, the post-processing step S4 may be performed for STEP 2 (filtering with radioactive material QMA) in the step (STEP) of the process list of FIG. 6 to automatically generate the process map of STEP 2 shown in FIG. 2. see.

First, one process corresponding to STEP 2 is read from the process list of FIG. 6 (S41). In the input information of the STEP 2 process of the process list of FIG. 6, the information for transporting is represented as the transporting information of the departure node 11 and the arrival node 35 and the compressed air.

Therefore, the transport path is generated through the shortest path map of FIG. 5 (20-21-22-23-24-17-Source 11 reverse from Sink 35), and according to the transport path, the connection path of the cassette valve in the process map, That is, the position item is set (S42). Specifically, the control command regarding the position of the cassette valve corresponding to the node 24 is set to 1 (see FIG. 4) so that the radioactive material can be transferred from the node 17 to the node 24, and the node 20 can be transferred from the node 20 to the node 35. The control command regarding the position of the cassette valve corresponding to the node 20 is set to 3 (see FIG. 4).

In addition, since compressed air, that is, gas is designated as a transfer method, an item of a gas valve (2-way valve) connected to node 4 corresponding to the gas supply unit of the compressed air, which is the designated gas, is set to 1 in an open state (S43). ).

In addition, since the syringe is not designated as the transfer method and is not described as information for chemical reaction, the step of setting the position change amount of the syringe (S44) and the step of setting the temperature and the holding time of the reactor (S45) are beyond. Goes. Thereafter, the process map is automatically generated in accordance with the setting of the cassette valve, the setting of the gas valve, the setting of the syringe, and the setting of the reactor (S46). Next, since the current process STEP 2 process is not the last process in the process list, the post-processing step (S4) described above is repeatedly performed for the next process STEP 3 process in the process list of FIG. It can be created automatically sequentially. After the post-processing step (S4) is performed in turn for each STEP in the process list of FIG. 6, after the post-processing step (S4) is performed for the last process STEP 10, there is no further process. Can be completed.

Synthesis of radiopharmaceuticals used for disease diagnosis cannot be synthesized by hand because of the use of radioactive materials. Synthesis is performed for high purity and high yield within a short time by automated synthesis equipment. For chemical reaction of radioactive materials and reagents, control of the valves and chemical reactions of the synthesis equipment is essential. For this purpose, the equipment actuator is controlled through a process map. In other words, process maps can be referred to as equipment work orders, and incorrect process maps can lead to equipment failures, malfunctions and leakage of radioactive material (reagents). Although it is necessary to repeat the experiments due to the change of the synthesis parameters when optimizing the synthesis procedure and developing new drugs, verification was very time-consuming and effort because the manual preparation of complex process maps can easily lead to errors.

However, according to the process map automatic generation method (S100), in order to eliminate an error in the process map creation, the composition diagram of the synthesis module is represented by a network, and the transport path of the solution (reagent or radioactive material) is expressed by the Dijkstra algorithm. By generating mathematically, accurate and error-free process maps can be generated quickly and automatically.

The process map automatic generation method (S100) can be mainly applied to the radiopharmaceutical synthesis module of the disposable cassette type, but can be used through the analysis of the equipment (actuator) in other synthesis equipment other than the disposable cassette type.

On the other hand, the computer-readable medium according to an embodiment of the present invention may include a program command for performing the process map automatic generation method (S100).

That is, embodiments of the present invention may include a computer-readable medium including program instructions for performing various computer-implemented operations. This medium records a program or a process for executing the present process map automatic generation method S100 as described so far. The medium may include program instructions, data files, data structures, etc., alone or in combination. Examples of such media include, but are not limited to, magnetic media such as hard disks, floppy disks and magnetic tape, optical recording media such as CDs and DVDs, floppy and magnetic-optical media, program instructions such as ROM, RAM and flash memory. Hardware devices configured to store and perform such operations. Or such medium may be a transmission medium, such as optical or metal lines, waveguides, etc., including a carrier wave that transmits a signal specifying a program command, data structure, or the like. Examples of program instructions may include machine language code such as those produced by a compiler, as well as high level language code that may be executed by a computer using an interpreter or the like.

While the present invention has been particularly shown and described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, And all changes and modifications to the scope of the invention.

S100. How to automatically generate this process map
S1. Steps to Modeling with the Network
S2. Steps to Create the Shortest Path Map
S3. Step of receiving process list
S4. Steps to Generate a Process Map

Claims (8)

Defining a synthesis module for synthesizing a radiopharmaceutical as a node and defining a connection member connecting the synthesis module as an arc, modeling the synthesis module and the connection member by a network;
Generating a shortest path map through which a dijkstra algorithm can transfer reagents or radioactive materials between nodes of the network,
Receiving a process list including information for transporting the reagent or radioactive material and information for chemical reaction, and
According to the process list, if there is information for the transfer to generate a process map for controlling the valve and syringe according to the transport path generated through the shortest path map, if the information for the chemical reaction and the temperature of the reactor Process map automatic generation method comprising the step of generating a process map to control the retention time. In claim 1,
Generating the process map
Reading one process from the process list,
Generating the transport path through the shortest path map and setting a connection path of a cassette valve in accordance with the transport path, when the one process includes the information for the transport;
Setting a gas valve connected to a gas supply unit of the designated gas to an open state when the one process has information for the conveyance and a gas is designated as the conveying method in the conveying information;
If there is information for the transfer in the one process, and a syringe is designated as the transfer method in the transfer information, the reagent or radioactive material may be transferred by the transfer amount specified in the transfer information. Setting the position change amount of the syringe,
If there is information for the chemical reaction in the one process, setting the temperature and the holding time of the reactor according to the information for the chemical reaction, and
And automatically generating the process map according to the cassette valve setting, the gas valve setting, the syringe setting, and the reactor setting. In claim 2,
The generating of the process map may be repeated for the next process of the one process when the one process is not the last process of the process list. In claim 1,
Synthesis module defined as a node of the network is any one of a storage unit for storing the reagent or radioactive material, a transfer unit for transporting the reagent or radioactive material, and a cassette valve for controlling the path to the reagent or radioactive material is transported ego,
A connecting member defined as an arc of the network is a process map auto-generation method of the tube through which the reagent or radioactive material flows. 5. The method of claim 4,
The transfer unit is a process map automatic generation method of any one of a syringe and a gas supply unit for transferring the reagent or radioactive material through the supply of gas. In claim 1,
The generating of the shortest path map may include selecting any arc among the two or more arcs, but preferentially the bidirectional arc when there are two or more arcs connecting the nodes of the network when generating the shortest path map. How to automatically generate the process map. In claim 1,
The information for transport includes information about a transport path including a departure node and an arrival node, information about a transport method, and information about a transport amount.
The information about the transport path further includes a pass-through node when there is a node to pass between the departure node and the arrival node,
The information on the transfer method is a process map auto-generating method of any one of a gas transfer method and the syringe transfer method. A computer readable medium comprising program instructions for performing the process map automatic generation method of claim 1.

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