KR20120089018A - Corrosion-inhibiting compositions for the medical instruments - Google Patents

Abstract

PURPOSE: A composition of a corrosion inhibitor for medical devices is provided to reduce chemical resistance generated in a boundary surface of grains or a local action of an electrolytic because a surfactant reduces a tension of a metallic surface of medical devices so that corrosion is prevented. CONSTITUTION: A composition of a corrosion inhibitor for medical devices comprises 0.5~15wt.% of an antioxidant and 0.05~5wt.% of a surfactant. The antioxidant comprises one kind being selected among polyphosphate, metaphosphate, and alkanolamine. An enhancer comprises one or more kinds being selected among citric acid, maleic acid, and metallic salt thereof.

Description

Corrosion-inhibiting compositions for the medical instruments

The present invention relates to a corrosion inhibitor composition for medical devices containing a non-toxic phosphate-based or amine-based compound as an antioxidant.

Corrosion mainly occurs at grain boundaries on metal surfaces and results from differences in chemical resistance or local electrolyte activity. In order to hygienically manage medical devices, sanitary processes, that is, cleaning, disinfection and sterilization processes are performed. Most medical devices (e.g. burs, finishers, handpieces, hand spreaders, pliers, end cutters, ligatures, etc.) It is prone to corrosion because it consists of a sharp surface and numerous small grooves. In addition, when corrosion occurs on the surface of the medical device, the pathogens are not easily disinfected and the pathogens survive, the pathogens remain as well as the grounds for the pathogens to remain, and because the organics remain, the pathogens are caused by these organics. This breeds. In addition, these organic substances cause a vicious cycle that causes corrosion while being oxidized in the autoclave process. As such, when corrosion occurs, not only disinfection is completely performed, but also shortens the service life of the device. Therefore, it is essential to treat medical devices with corrosion inhibitors in order to keep medical devices such as medical devices hygienic and long life of the devices.

Korean Patent No. 10-0978822 describes corrosion inhibitors containing alkylpyrrolidone or alkylamine, and commercially available products (products of NIPPON SHIKA YAKUHIN CO., LTD) as corrosion inhibitors are corrosion resistant. As a component, it contains nitrites, which are classified as toxic substances in the National Institute of Environmental Research's chemical information system. have. In addition, the conventional corrosion inhibitor for medical devices has a problem that contains harmful components such as heavy metals or toxic substances.

Accordingly, the present inventors have tried to solve the problems of the conventional corrosion inhibitors for medical devices, by using at least one antioxidant selected from phosphates, polyphosphates, metaphosphates and alkanolamines, and also contains a promoter and a surfactant We have completed a corrosion inhibitor for medical devices that does not contain nitrites that are harmful to humans, which are classified as toxic in the Chemical Information System of the Environmental Science Institute. Accordingly, an object of the present invention is to provide a corrosion inhibitor for medical devices excellent in corrosion resistance and rust resistance.

The present invention

Per 100 parts by weight of water

0.5 to 15 parts by weight of at least one antioxidant selected from phosphates, polyphosphates, metaphosphates and alkanolamines;

0.5 to 10 parts by weight of at least one enhancer selected from citric acid, maleic acid and metal salts thereof; And

0.05 to 5 parts by weight of surfactant;

Characterized by the corrosion inhibitor composition for medical devices comprising a.

The anticorrosive composition for medical devices of the present invention is excellent in rust resistance even though it does not contain nitrite, heavy metal or toxic substances harmful to the human body, and particularly excellent corrosion resistance.

1 is a result of observing the rust occurrence over time after immersing the stainless specimen and iron plate specimen in tap water.
Figure 2 is a photograph of the specimen and the composition observed after 30 days after immersing the stainless specimen and iron plate specimen in the composition of Example 1.
3 is a result of observing over time after immersion of dental medical instruments in tap water, whether or not rust occurs.
4 is a result of observing over time the rust occurs after immersing the dental medical instruments in the composition of Example 1.

Hereinafter, the present invention will be described in more detail.

The present invention comprises at least one antioxidant selected from phosphates, polyphosphates, metaphosphates and alkanolamines; At least one enhancer selected from citric acid, maleic acid and metal salts thereof; And to a corrosion inhibitor composition for medical devices in which the surfactant is dissolved in water, the composition is safe for the human body as substances used in food.

At least one substance selected from the above phosphates, polyphosphates, metaphosphates and alkanolamines is used in the present invention to obtain an antioxidant effect. That is, the antioxidant effect is expressed through the principle of forming an insoluble coating film. The phosphates, polyphosphates and metaphosphates are preferably in the form of alkali metal salts or alkaline earth metal salts. In addition, the alkanolamine may be triethanolamine, isopropanolamine or a mixture thereof, preferably triethanolamine. It is preferable to use such antioxidants in an amount of 0.5 to 15 parts by weight based on 100 parts by weight of water. If the amount is less than 0.5 parts by weight, it is difficult to obtain a sufficient antioxidant effect. Endo box of tin material used in the dentist may be a problem that may react with the use within the above range.

At least one selected from citric acid, maleic acid, and metal salts thereof, which is another composition of the present invention, serves to enhance the effect of the antioxidant through a chelation principle. As the metal salt, it is preferable to use an alkali metal salt or an alkaline earth metal salt. The content of such enhancers is preferably used in an amount of 0.5 to 10 parts by weight based on 100 parts by weight of water. If the amount is less than 0.5 parts by weight, the benefits of the use are insignificant. Since it is difficult to expect the cost, it is better to select the above range. In addition, by containing the enhancer in the above range, the corrosion inhibitor composition for medical devices of the present invention has an alkalinity of pH between 7.5 and 11.0.

The surfactant serves to prevent corrosion by reducing the surface tension of the metal surface of the medical device, thereby reducing chemical resistance or local electrolyte activity occurring at the grain interface. As the surfactant, a low foaming ethoxylated propoxylated alcohol, polyoxyethylene oxypropylene glycol ether or a mixture thereof may be used. The surfactant is preferably used in an amount of 0.05 to 5 parts by weight based on 100 parts by weight of water. At this time, when the amount of the surfactant is less than 0.05 parts by weight, the amount is too small to expect a surface tension reduction effect, and is more than 5 parts by weight. If there is a problem in that the delamination phenomenon may occur because it is not completely dissolved in water, it is good to use within the above range.

The preservative composition for medical devices of the present invention may further include a microbial inhibitor for preventing the growth of microorganisms as necessary. Microbial inhibitors that can be used include at least one selected from sorbic acid, benzoic acid and metal salts thereof. The metal salt is preferably used in the form of an alkali metal salt or alkaline earth metal salt. When using a microbial inhibitor, it is preferable to contain 0.1 to 15 parts by weight with respect to 100 parts by weight of water. If the amount is less than 0.1 parts by weight, it is insufficient to prevent the growth of microorganisms. It is advisable to select this range because the benefits of the phase are minimal.

The anticorrosive composition for medical devices of the present invention exhibits excellent rust resistance and corrosion resistance without containing nitrite, heavy metal or toxic substances harmful to the human body.

Hereinafter, the present invention will be described in more detail based on examples. However, the scope of the present invention is not limited to the following examples.

[ Example ]

To 100 parts by weight of water to dissolve the composition in the composition shown in Table 1 to prepare a corrosion inhibitor composition for medical devices.

Division (weight part) Example Comparative example One 2 3 4 5 One 2 3 4 5 phosphate Dibasic Sodium Phosphate 2 - - - - 6 - - - - Trisodium Phosphate - - - - 4 - 2 - - - Sodium polyphosphate - 4 - - - - - - - 4 Triethanolamine 8 - 8 10 - - - 6 4 - Citric acid 2 4 4 2 4 4 4 2 - - Surfactants 3 3 3 3 3 - - - 3 - Sorbic acid 3 5 3 3 - 3 - 3 3 3 Surfactant: Polyoxyethylene oxypropylene glycol ether

Corrosion resistance  exam

The test was carried out using the compositions obtained in Examples 1 to 5 and Comparative Examples 1 to 5 and tap water as a control. After immersing the stainless steel (SUS304) specimen and the iron plate specimen in each composition and tap water, and left for 30 days, the time when rust occurs was measured. Also, dental medical equipment Finishers, pliers and end cutters were soaked and left for 30 days, and the time point at which rust occurred was measured. The test results are shown in Table 2 below.

division Example Comparative example tap water One 2 3 4 5 One 2 3 4 5 SUS + iron plate X X X X X ○ ○ ○ ○ ○ 3 hours Medical equipment X X X X X ○ ○ ○ ○ ○ 2 days

As shown in FIG. 1, FIG. 3, and Table 2, when SUS specimen and iron plate specimen were immersed together in tap water as a control, rust may be generated after 3 hours. In the case of dental equipment, the material is stainless, there is a tip titanium, chromium alloys, an aluminum alloy such as a corrosion resistance superior to general steel plates, the corrosion was not generated dipped in water is 2 let lapse.

In Examples 1 to 5, rust did not occur on the SUS specimen, the iron plate specimen, and the dental medical device even after 30 days, but in the case of Comparative Examples 1 to 3, which did not contain the surfactant polyoxyethylene oxypropylene glycol ether, 2 days After the rust developed, the effects of chemical resistance at the grain boundary and local decrease in electrolyte activity were identified. In addition, in the case of Comparative Examples 4 to 5 that do not contain citric acid as an enhancer, rust occurred after 2 days.

After all, the anti-corrosive composition of the present invention shows an excellent anti-corrosion effect without containing toxic substances such as night light, it can be confirmed that it can be usefully applied as a corrosion inhibitor of medical devices such as dental medical instruments or surgical instruments. there was.

Claims (7)

Per 100 parts by weight of water
0.5 to 15 parts by weight of at least one antioxidant selected from phosphates, polyphosphates, metaphosphates and alkanolamines;
0.5 to 10 parts by weight of at least one enhancer selected from citric acid, maleic acid and metal salts thereof; And
0.05 to 5 parts by weight of surfactant;
Anticorrosive composition for medical devices comprising a.
The anticorrosive composition for medical devices according to claim 1, further comprising at least one microbial inhibitor selected from sorbic acid, benzoic acid and metal salts thereof.
According to claim 2, wherein the microbial inhibitor is a corrosion inhibitor composition for medical devices, characterized in that contained in 0.1 to 15 parts by weight based on 100 parts by weight of water.
The method of claim 1, wherein the phosphate, polyphosphate and metaphosphate is a corrosion inhibitor composition for medical devices, characterized in that in the form of an alkali metal salt or alkaline earth metal salt.
The method of claim 1, wherein the alkanolamine is triethanolamine, isopropanolamine or a mixture thereof, characterized in that the corrosion inhibitor composition for medical devices.
The method of claim 1, wherein the metal salt is a corrosion inhibitor composition for medical devices, characterized in that the alkali metal salt or alkaline earth metal salt.
The method of claim 1, wherein the surfactant is ethoxylated propoxylated alcohol, polyoxyethylene oxypropylene glycol ether (corrosive agent composition for medical devices), characterized in that a mixture thereof.

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