KR20120062221A - Compound for detecting mercury ion, preparation method of the same and fluorogenic chemodosimetric system using the same - Google Patents

Compound for detecting mercury ion, preparation method of the same and fluorogenic chemodosimetric system using the same Download PDF

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KR20120062221A
KR20120062221A KR1020100123385A KR20100123385A KR20120062221A KR 20120062221 A KR20120062221 A KR 20120062221A KR 1020100123385 A KR1020100123385 A KR 1020100123385A KR 20100123385 A KR20100123385 A KR 20100123385A KR 20120062221 A KR20120062221 A KR 20120062221A
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compound
mercury
ions
fluorescence
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KR101171801B1 (en
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김종승
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고려대학교 산학협력단
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
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    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

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Abstract

PURPOSE: A compound for detecting hydrargyrum ions, a method for manufacturing the same, and a fluorescent chemical detecting system using the same are provided to selectively detect hydrargyrum from an aqueous solution containing other metallic ions. CONSTITUTION: A compound for detecting hydrargyrum ions is represented by chemical formula 1. A fluorescent chemical detecting system includes the compound and o-phenylenediamine. Hydrargyrum is reacted with the compound and o-phenylenediamine, and hydrargyrum is detected based on the reinforced fluorescent of a resultant product. The hydrargyrum ion detecting operation is implemented in an aqueous solution.

Description

Compound for mercury ion detection, preparation method thereof, and fluorescence chemical detection system using same {COMPOUND FOR DETECTING MERCURY ION, PREPARATION METHOD OF THE SAME AND FLUOROGENIC CHEMODOSIMETRIC SYSTEM USING THE SAME}

The present invention relates to a compound for detecting mercury ions and a fluorescence chemical detection system including the same. More specifically, a compound for detecting mercury ions capable of effectively detecting the presence and concentration of mercury based on an intermolecular reaction and a novel method using the same One fluorescence chemical detection system.

Recently, due to the harmful effects of heavy- and transition-metal (HTM) ions on living organisms and the environment, there is a growing interest in the detection and quantification of these metals. At low concentrations in the environment, it is highly toxic.Methylmercury, when ingested by humans, is known to cause serious diseases including diseases of the sensory, muscular and nervous systems.

BACKGROUND OF THE INVENTION Fluorescent chemosensors have been developed as a number of precise analytical methods for detecting mercury ions. Recently, the chemodometer approach has received a high interest due to its simplicity, high sensitivity, high selectivity and irreversibility. have. Most of these detection techniques are designed based on mercury-induced desulfurization.

However, there is a need for development of a fluorescent dye and a fluorescence chemical detection system using the same to detect mercury ions more effectively in the desulfurization reaction.

The problem to be solved by the present invention is to provide a compound for detecting mercury ions, a method for producing the same that can more effectively detect the presence and concentration of mercury ions based on the intermolecular reaction.

In addition, another object of the present invention is to provide a fluorescence chemical detection system and a detection method using the mercury ion detection compound.

In order to solve the above problems, the present invention provides a compound for detecting mercury ions represented by the following formula (1).

[Formula 1]

Figure pat00001

In another aspect, the present invention provides a method for producing a compound for detecting mercury ions of claim 1, which is prepared by the following Scheme 1.

Scheme 1

Figure pat00002

In another aspect, the present invention provides a mercury ion detection fluorescent chemical system comprising the compound of Formula 1 and o-phenylenediamine (o-PDA). In this case, the detection of the mercury ions is characterized in that the mercury is carried out by fluorescence enhancement of the material generated while reacting with the compound of Formula 1 and o-phenylenediamine, the specific mechanism is as follows. In particular, mercury ion detection according to the present invention can be carried out in an aqueous solution is very useful.

Figure pat00003

The present invention also provides a method for selectively detecting mercury ions using the mercury ion detection fluorescence chemistry system.

The fluorescent chemical detection system according to the present invention can effectively detect mercury ions using the compound represented by Formula 1 and o-phenylenediamine (o-PDA). Specifically, since the compound of formula (1) and o-phenylenediamine, which do not exhibit fluorescence, react with mercury ions to form a new substance exhibiting strong fluorescence, mercury ions can be detected simply enough to be observed with the naked eye. . It is also an advantage that it can be selectively detected even in the presence of other metal ions, especially in aqueous solution.

1 is a graph showing fluorescence emission intensity when mercury ions are added to a fluorescence chemical detection system according to an embodiment of the present invention.
2 is a graph showing color change and UV-vis spectrum when various metal ions are added to a fluorescence chemical detection system according to an embodiment of the present invention.
3 is a graph showing fluorescence enhancement when various metal ions are added to a fluorescence chemical detection system according to an embodiment of the present invention.
FIG. 4 is a graph showing a process of partially changing the 1 H NMR (300 MHz) spectrum of Formula 1 according to the addition of Hg (ClO 4 ) 2 .xH 2 O (1 eq.) In CD 3 CN.
Figure 5 is a graph showing the change in fluorescence Hg 2 + (1 eq.) Compound (20 μM) of the formula (1) after a review of UV (365 nm) for 5 minutes in the presence of and o- phenylenediamine (3 eq.) to be.
6 is Hg 2 + (1 eq.) Compound of Formula (20 μM) and of o- 1 when no irradiation with the case examining the UV (handhold UV lamp, 365 nm ) in the presence of the phenylenediamine (3 eq. ) Is a graph showing the fluorescence reaction.
7 is a graph showing the fluorescent reaction of CH 3 CN from the Hg + 2 and the present compounds of formula (1) the absence of the ion (20μM) (20μM) and o- phenylenediamine detection system according to a molar ratio of diamine. (λ ex = 380 nm) The emission intensity change at 492 nm according to the molar ratio of Formula 1 and o-phenylenediamine is inserted.
8 is Hg + 2 ions are 1 H NMR (300 MHz) spectrum of o- phenylenediamine changes with the addition of (1 eq.) In CD 3 CN is a graph illustrating a process in part.
9 is a graph showing the fluorescent reaction of formula (3) compound (10 μM) in accordance with the addition of Hg 2 + ions (0-100 eq) in CH 3 CN. (λ ex = 380 nm) A ratiometric calibration curve of I 454 / I 492 is inserted as a function of the molar ratio function of Formula 3 and mercury ions.
10 is Hg + 2 ions are 1 H NMR (300 MHz) spectrum of compound (4 mM) of formula (3) changes with the addition of (0.2-1 eq.) In CD 3 CN is a graph illustrating a process in part.
11 is a graph showing the fluorescence of the compounds (10 μM) of formula (3) When the addition of Hg 2 + ions and o-PDA in different concentrations in CD 3 CN).
12 is a CH 3 CN from among Ag +, Ba 2 +, Ca 2 +, Cd 2 +, Co 2 +, Cu 2 +, Cs 2 +, Fe 2 +, K + , Li + , Mg 2+ , Na + , Pb 2 + , Rb + , Sr 2 + , Zn 2 + (10 eq.), Cu 2 + (5 eq.) And Hg 2 + (1 eq.) It is a graph showing the fluorescence spectrum of the fluorescence chemical detection system of the present invention (Formula 1 (20 μM) and o- PDA (3 eq.)) According to the addition of various metal ions including.
13 is a CH 3 CN in Hg 2 + Ag + in the presence of (1 eq.), Ba 2 +, Ca 2 +, Cd 2 +, Co 2 +, Cs 2+, Fe 2 +, K +, Li +, Mg 2 +, Na +, Pb 2 +, Rb +, Sr 2 +, Zn 2 + number of the metal ion containing (10 eq.) And Cu 2 + (1 eq.) ) Of It is a graph showing the fluorescence spectrum of the present invention fluorescence chemical detection system (Formula 1 (20 μM) and o- PDA (3 eq.)) With addition.
14 is Hg + 2 under the presence of Cu 2 (1 eq.) + (4 eq.) To contain a high concentration and, o -PDA (7 eq.) Was further added when the present invention system (I (20 μM) and o- PDA (3 eq.)) are graphs showing the fluorescence spectrum.
15 is a graph showing the 1 H NMR spectrum of the compound of Formula 3 measured in CDCl 3 .

Hereinafter, the present invention will be described in more detail.

The inventors have designed and synthesized a novel system for detecting mercury ions using mercury-desulfurization.

One of the compounds for detecting mercury ions according to the present invention is represented by the following formula (1).

[Formula 1]

Figure pat00004

In addition, the compound of Formula (1) may be prepared by the following Scheme 1.

Scheme 1

Figure pat00005

The present invention provides a mercury ion detection fluorescent chemical system comprising the compound of Formula 1 and o-phenylenediamine (o-PDA). In this case, the detection of the mercury ions is characterized in that the mercury is carried out by fluorescence enhancement of the material generated while reacting with the compound of Formula 1 and o-phenylenediamine, in particular the mercury ion detection according to the invention can be carried out in an aqueous solution It's very useful.

The present invention also provides a method for selectively detecting mercury ions using the mercury ion detection fluorescence chemistry system.

Hereinafter, preferred examples are provided to aid in understanding the present invention. However, the following examples are only provided by way of example in order to make the present invention easier to understand, and should not be construed as limiting the scope of the present invention.

Synthetic example  : Synthesis of Compound of Formula (1)

Mercury ion detection compound (Formula 1) according to the present invention was prepared by the following Scheme 1.

Scheme 1

Figure pat00006

The yield of compound (1) produced according to this reaction was quite high, 89%.

Example  : Mercury Detection Fluorescence Chemical System

In the mercury ion detection fluorescence chemical system according to the present invention is a specific mechanism for detecting mercury ions are as follows.

Figure pat00007

In the reaction, 6,10-dithiaspiro-acenaphthene quinine (Compound 1) is chemically reacted with o-phenylenediamine (o-PDA) in the presence of mercury ions. The compound 3 can be formed, and as a result, the fluorescent signal can be amplified.

When mercury ions are added to a mixture of non-fluorescent Compound 1 and o-PDA, it promotes desulfurization reaction to form Compound 2, an unstable spiro heterocyclic intermediate compound, which is converted to Compound 3 through intermolecular rearrangement. . The synthesis of compound 3 is well supported by spectroscopic results, but the mechanism for this is not clear. Compound 3 is a classic dye having strong green fluorescence, and is widely used as a basic skeleton of new organic pigments, laser dyes, textile dyes, and polymer fibers.

UV irradiation of the mixture of Compound 1, PDA and mercury ions in CH 3 CN can be seen to accelerate the reaction rate, the fluorescence intensity is remarkably increased at 492nm when irradiated with UV lamp (365nm) for 5 minutes It can be seen that the increase. In addition, the molar ratio of Compound 1 and PDA may also affect the reaction rate.

In order to optimize the fluorescence chemidetection system according to the invention, the compounds 1 and o-PDA were tested in different molar ratios in the presence of the same mercury ions (20 μM) in CH 3 CN. As a result, the molar ratio of the probe represented by the formula (1) and o-PDA in the fluorescence chemical detection system according to the present invention is preferably 1: 3, but is not limited thereto.

Fluorescence emission intensity in which mercury ions (0 to 100 μM) was added to a fluorescence chemical detection system (probe represented by Formula 1 (20 μM) and o-PDA (3eq.)) According to the present invention in CH 3 CN is shown in FIG. 1. Shown in

As shown in Figure 1 below, the fluorescent titration curves of Compound 1 and o-PDA for mercury ions indicate that the concentration of mercury ions can affect the emission wavelength as well as the emission intensity. Under low mercury ion concentrations (0-1.4 eq.), Fluorescence emission was seen at 492 nm, and the emission intensity was gradually enhanced with increasing mercury ions. The addition of additional mercury ions (> 1.4 eq) gradually reduced the emission band at 492 nm and concomitantly caused a blue shift to 454 nm. This may be due to the interaction of compound 3 with mercury ions, or due to excess mercury ions reducing the concentration of free o-PDA in solution, preventing the formation of compound 3 and thus reducing the emission intensity.

To account for this fluorescence change in the presence of excess mercury ions, the fluorescence spectral change was tested while gradually adding mercury ions to the solution of compound 3. The strong emission at 492 nm of compound 3 gradually blue shifted and reached λ max = 454 nm with a significant increase in fluorescence emission intensity at a mercury ion concentration of 150 μM.

NMR titration experiments were performed to study the mechanism between compound 3 and mercury ions. Comparing the 1 H NMR spectra before and after the addition of mercury ions to compound 3, it can be seen that all protons moved downward. This change in spectrum is due to the complex of metal ions in which mercury ions bind to the nitrogen of the imidazole ring of compound 3. In addition, the complexation between compound 3 and mercury ions is weaker than that for o-PDA. Thus, by adjusting the concentration of o-PDA in solution, the emission intensity and emission wavelength of the sample can be controlled. The change in fluorescence spectral dependence on the concentration of mercury ions indicates that the system according to the invention can not only detect mercuric ions but also its concentration level.

The color change and UV-vis spectrum when various metal ions are added to the fluorescence chemical detection system according to an embodiment of the present invention are shown in FIG. 2. More specifically, various metal ions (Ag + , Ba 2 + , Ca 2 + , Cd 2 + , Co 2 + , Cu 2 + , Cs 2 + , Fe 2+ , K + , Li + , in CH 3 CN Mg 2 +, Na +, Pb 2 +, Rb +, Sr 2 +, Zn 2 + (10eq.), Hg 2 + compound 1 in the presence of (1eq.)) (20μM), and o-PDA (3eq.) The color change of and the UV-vis spectrum is shown.

UV-vis spectral behavior for representative metal ions of the fluorescence chemical detection system according to the present invention was carried out using physiologically important alkali metals, alkaline earth metals and transition metal perchlorates in CH 3 CN. Upon interaction with various metal ions, a significant change in absorption spectrum was observed, especially in the case of copper ions, which was found to readily bind to PDA in the solution, resulting in CuPDA x (ClO 4 ) 2 (x = 1 or 2) This is because it forms a complex. Incidentally, a color change from colorless to brown was also observed.

Fluorescence enhancement when various metal ions were added to the fluorescence chemical detection system according to an embodiment of the present invention is shown in FIG. 3.

In terms of practical applications, interference with other metal ions should be considered. Thus, the fluorescence changes for mercury ions in the presence of other competing metal ions were observed and shown in FIG. 3.

Ag +, Ba 2 +, Ca 2 +, Cd 2 +, Co 2 +, Cu 2 +, Cs 2 +, K +, Li +, Mg 2 +, heavy metals, such as Na +, Rb +, Sr 2 +, It was observed that alkali metal and alkaline earth metal had no effect even at high concentrations. Only, Fe + 2, Pb + 2, and exhibited a relatively low fluorescence enhanced only when the addition of the Zn + 2. Ag +, and the leading edge part of the transition metal, such as Co 2 +, Zn 2 +, and the metal is reduced the fluorescence intensity due to compounding ability with o-PDA of their own. In addition, there is a strong interaction between copper ions and o-PDA, such that the presence of high concentrations of copper ions can interfere with the formation of compound 3, resulting in disappearing fluorescence. The addition of additional o-PDA can restore a strong fluorescence signal for mercury ions.

In conclusion, the fluorescent chemistry detection system according to the present invention can selectively exhibit high fluorescence for mercury ions. Therefore, it can be more usefully used for detecting mercury ions and can be effectively used even in the presence of other competitive metal ions.

Claims (7)

Mercury ion detection compound represented by the following formula (1):
[Formula 1]
Figure pat00008
 Method for producing a compound for detecting mercury ions of claim 1, which is prepared by the following Scheme 1:
[Reaction Scheme 1]
Figure pat00009
 Mercury ion detection fluorescence chemical system comprising a compound of formula 1 according to claim 1 and o-phenylenediamine (o-PDA). The method of claim 3,
The mercury ion detection fluorescence chemistry system, characterized in that the detection of the mercury ion is carried out by fluorescence intensification of the material generated while the mercury reacts with the compound of formula (1) and o-phenylenediamine. The method of claim 4, wherein
Mercury ion detection fluorescence chemistry system, characterized in that the detection of the mercury ion is carried out through the following mechanism:
Figure pat00010
 The method of claim 3,
The mercury ion detection fluorescence chemical system, characterized in that the mercury ion detection is carried out in an aqueous solution.  A method for selectively detecting mercury ions using a mercury ion detection fluorescence chemistry system according to claim 3.
KR20100123385A 2010-12-06 2010-12-06 Compound for detecting mercury ion, preparation method of the same and fluorogenic chemodosimetric system using the same KR101171801B1 (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101505467B1 (en) * 2013-04-16 2015-03-25 고려대학교 산학협력단 Chemosensor for detecting divalent mercury ions and method for preparing the same
CN114105979A (en) * 2021-11-27 2022-03-01 大连医科大学附属第二医院 Application of broad-spectrum fluorescent probe for detecting cytochrome oxidase CYP3A

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110615785A (en) * 2018-06-20 2019-12-27 南京大学 Novel Hg2+Synthesis and application of ion probe

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101505467B1 (en) * 2013-04-16 2015-03-25 고려대학교 산학협력단 Chemosensor for detecting divalent mercury ions and method for preparing the same
CN114105979A (en) * 2021-11-27 2022-03-01 大连医科大学附属第二医院 Application of broad-spectrum fluorescent probe for detecting cytochrome oxidase CYP3A

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