KR20120011575A - Verification equipment of target point and dose distribution for stereotactic brain radiosurgery - Google Patents

Abstract

PURPOSE: A target of brain stereotactic radio-surgery and a verifying device of radiation distribution are provided to copy a tumor to be a target of radio-surgery and to confirm 3D radiation distribution by using a gel instrument. CONSTITUTION: An anatomical phantom(110) has radio transparent. Liquid filler(111) is filled in a cavity(110a) of the phantom. A plurality of gel instruments(120) is arranged in order to be respectively corresponded to a verification object location. A bottom plate(130) comprises a plurality of insertion holes. A plurality of receiving parts(140) respectively accepts the gel instrument in inside. One end of a plurality of connection parts(150) is respectively inserted into the insertion hole of the bottom plate. The other end of a plurality of connection parts is connected to the receiving part. A sealing part(160) seals the cavity of the phantom.

Description

Verification equipment of target point and dose distribution for stereotactic brain radiosurgery

The present invention improves the success rate of radiosurgery by verifying in advance the rotational center point (Isocenter) and the radiation dose distribution corresponding to the target lesion that is the target of radiosurgery prior to the treatment by seroactic brain radiosurgery. The present invention relates to a verification device for ensuring safety.

In the case of stereotactic radiosurgery, a single irradiation of several to several tens of Gy (Gray) is applied to the patient, so verification of the rotational center point and radiation dose distribution is more important than general radiation therapy.

 In general, the verification of the rotational center point is performed by a Winston-Lutz test using a normal film. According to the Winston-Lutz test, only a two-dimensional center of rotation analysis at the angle of the gantry and the treatment table which is frequently used in the treatment by the actual radiation surgery can be performed. In other words, the Winston-Lutz test has the limitation that it is impossible to analyze the three-dimensional center of rotation at all gantry and treatment table angles.

 On the other hand, for quality control of dose distribution, radiation measuring dosimeters such as films or 2D-diode arrays are generally used, but these two-dimensional instruments also have a dose distribution in each cross section. Only you can check. Therefore, the three-dimensional dose distribution is confirmed through the reconstruction of the image by an additional program.

However, because the object of radiosurgery has three-dimensional volume and exists in three-dimensional space, three-dimensional verification is necessary. However, since the image implemented in three dimensions by a program is reconstructed, it is not an actual three dimensional (3D).

In more detail, the maximum volume of the target lesion that is the target of actual radiation surgery is about 15 cc (approximately 3 cm in diameter) for single session radiosurgery, and that of Fractionated radiosurgery. Since it is about 250cc (approximately 8cm in diameter), it is almost impossible to obtain three-dimensional image data by reconstructing a two-dimensional image using a film. There is this.

The present invention was created in order to solve the above problems, it is possible to verify the three-dimensional rotation center point and the radiation dose distribution so as to correspond to the target lesion of the radiation surgery target in the three-dimensional volume and exist in the three-dimensional space The purpose of the present invention is to provide a device for verifying the target point and radiation distribution of cerebral stereotactic radiosurgery.

The apparatus for verifying the target point and the radiation distribution of the stereotactic radiosurgery according to the present invention comprises: an anatomical phantom having a shape of a head of a human body, having an opening at a lower portion thereof and an empty cavity at an inner portion thereof; Liquid filling the cavity of the phantom; A plurality of gel measuring instruments arranged to correspond to the verification target positions to simulate each lesion (tumor) and made of muscle equivalents in a gel state; A bottom plate installed in an opening formed at a lower portion of the phantom, and having a plurality of insertion holes formed therein corresponding to the number of the gel measuring instruments; A plurality of accommodating parts accommodating the gel meter therein and having radiation permeability; A plurality of connecting portions, one end of which is inserted into the insertion hole of the bottom plate and the other end of which is connected to the receiving portion; And a sealing part installed at the bottom of the bottom plate to seal the cavity of the phantom so that the filling does not leak to the outside.

Here, the upper surface of the receiving portion, the micropores for injecting or discharging the components of the gel measuring instrument through a medical syringe may be formed.

In addition, the muscle equivalent of the gel meter may include gelatin (Gelatin), methacrylic acid (Methacrylic acid), and water (H 2 O).

Meanwhile, the apparatus for verifying a target point and a radiation distribution of the cerebral stereotactic radiosurgery may further include a plate-shaped auxiliary fixing part having a plurality of fixing holes for inserting the connecting portions to fix the position thereof.

Here, among the insertion holes formed in the bottom plate, the insertion hole formed in the inner portion is formed to be perpendicular to the bottom, the insertion hole formed in the edge portion may be formed to be inclined outward in a direction perpendicular to the floor.

In addition, among the fixing holes formed in the auxiliary fixing portion, the fixing hole formed in the inner portion is formed to be perpendicular to the bottom corresponding to the insertion hole formed in the inner portion, the fixing hole formed in the edge portion corresponding to the insertion hole formed in the edge portion It may be formed to tilt outward.

According to the verification device of the target point and the radiation distribution of the stereotactic radiosurgery according to the present invention, it is possible to simulate the tumor that is the target of the actual radiation surgery, and by using a gel measuring instrument that can confirm the three-dimensional radiation distribution radiation before treatment Since it can be used as a three-dimensional verification tool of the surgical plan, it is possible to use as much as possible in the actual radiosurgical environment for a radiation surgical target (target lesion) having a three-dimensional volume and existing in three-dimensional space. Providing close and precise verification results.

1A and 1B are cross-sectional views for explaining target lesions (tumors) located in the human brain, which is the object of simulation;
Figure 2 is a front view showing the verification device of the target point and the radiation distribution of the stereotactic radiosurgery according to an embodiment of the present invention,
3 is a partial coupling diagram showing a coupling structure of the gel measuring instrument, the bottom plate, the receiving portion, the connecting portion and the auxiliary fixing shown in FIG.
4A and 4B show the bottom plate shown in FIG. 2, FIG.
5 is a partial coupling view for explaining the coupling relationship of the gel measuring instrument, the receiving portion and the connecting portion shown in FIG.
6 is a perspective view of the auxiliary fixing part shown in FIG.
FIG. 7 is a view showing the sealing part shown in FIG. 2.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

 The human brain can be divided into six parts: frontal lobe, parietal lobe, occipital lobe, temporal lobe, cerebellum, and brain stem. Can be. In FIG. 1A and FIG. 1B, tumors located in each part (total 6 parts) are indicated by dots.

Verification apparatus 100 to be described later (FIG. 2) is implemented to simulate each tumor that is a target lesion that is the target of radiation surgery. For example, the number of tumors to be simulated in each site can be determined by two frontal lobes, two occipital lobes, two temporal lobes, one cerebellum, and three brain stems, depending on the clinical experience and needs of radiosurgery. The two tumors located in the frontal lobe, the occipital lobe, and the temporal lobe are symmetrical with each other, and the brain stem can be simulated with two pons and one training. Here the two pontoons are positioned to be symmetrical to each other.

2 and 3, the apparatus 100 for verifying the target point and the radiation distribution of the stereotactic radiosurgery according to an embodiment of the present invention includes an anatomical phantom 110, a liquid filling 111, and a plurality of Gel measuring instrument 120, bottom plate 130, a plurality of accommodating portions 140, a plurality of connecting portions 150, and a sealing portion 160.

The anatomical phantom 110 is a shape of the head of the human body, and simulates the surface portion of the human head. The lower portion of the anatomical phantom 110 is opened, and the interior thereof forms an empty cavity 110a. When the anatomical phantom 110 is irradiated, it must be transmissive, and for example, an acrylic material may be used. In addition, the phantom 110 is filled with the liquid filling 111 in the cavity 110a, and may be used for commercial RSVP Phantom ^™ used for quality control of radiation surgery by filling water.

The gel measuring unit 120 is arranged to correspond to the verification target position to simulate each lesion (tumor). The gel meter 120 is made of the muscle equivalent of the gel (Gel) state. The muscle equivalent material may include gelatin (gelatin), methacrylic acid (methacrylic acid) and water (H 2 O). These muscle equivalents show a polymerization reaction when they receive radiation, and the point changes. In general, the degree of gel change can be visually estimated through MRI image (T2 image), and quantitative analysis using transverse relaxation time (T2) is also possible.

In more detail, the gel meter 120 is irradiated with radiation, and the reaction degree is quantified using the inverse value of the transverse relaxation time (T2). That is, the degree of reaction of the gel meter 120 according to the radiation dose is quantified. The curve that shows the reciprocal of the transverse relaxation time according to the radiation dose using the quantified value is called the "characteristic curve". When this characteristic curve is completed, the gel meter 120 is irradiated with a radiation treatment plan to be verified and the distribution of the radiation dose is confirmed and verified using the characteristic curve.

 The anatomical phantom 110 is accommodated in the receiving portion 140 to be described later, it is fixed to the bottom plate 130 by the connecting portion 150.

The bottom plate 130 is installed in an opening formed under the phantom 110. And a plurality of insertion holes 131 corresponding to the number of the gel measuring unit 120 is formed on the top of the bottom plate 130. 4A and 4B, the position of each of the insertion holes 131 is determined in consideration of the length of the connection part 150 and the angle of insertion. For example, positions 1 and 2 are the frontal lobe tumors, positions 3 and 4 are the temporal lobe tumors, positions 5 and 6 are the occipital lobe tumors, position 7 is the cerebellar tumor, and positions 8 and 9 are the glial tumors. , Position 10 may be arranged as a hole to be inserted by the connection portion 150 to support and fix the gel meter 120, each to simulate a soft tumor.

As shown in FIG. 5, the accommodating part 140 accommodates the gel meter 120 therein, respectively. The receiving portion 140 may have a hollow cylindrical shape, but the shape thereof is not limited thereto, and should have radiation permeability. Preferably, an acrylic material can be used. And the upper surface 141 of the receiving portion 140 to form a fine hole (141a), through which the composition of the gel meter 120 can be injected or discharged through the medical syringe.

One end of the connection part 150 is inserted into the insertion hole 131 of the bottom plate 130, and the other end thereof is connected to the accommodation part 140. The connection portion may be in the form of a hollow cylindrical bar, but the shape is not limited. The connection part 150 may also use an acrylic material.

On the other hand, in the embodiment of the present invention as described above, the angle of the insertion hole 130 of the bottom plate 130 to be inserted into the connection portion 150 is the length of the connection portion 150 to be used and the anatomical position of the tumor that is the target lesion It is decided by considering. Here, the angle is defined as the angle θ between the axis of the connecting portion 150 inclined in the radial direction and the vertical axis.

In other words, of the insertion holes 131 formed in the bottom plate 130, respectively, as shown in FIGS. 4A and 4B, the insertion holes 131a formed on the inner side thereof are formed to be perpendicular to the bottom, and formed on the edge portion thereof. The insertion hole 131b may be formed to tilt outward in a direction perpendicular to the bottom. Here, all the insertion holes 131b except for the vertical insertion hole 131a may be adjusted at an angle of 10 degrees for convenience of manufacturing.

As shown in FIG. 6, the verification apparatus 100 includes a plurality of fixing holes 171 to insert the connecting portions 150 to fix the positions of the connecting portions 150 so that the positions thereof are fixed. The plate-shaped auxiliary fixing part 170 may be further provided. The fixing hole 171 formed in the auxiliary fixing part 170 corresponds to the angle of the insertion hole 131 formed in the bottom plate 130, respectively, and the fixing hole 171a formed in the inner part is inserted into the inner part. The fixing hole 171b formed at the edge portion may be perpendicular to the bottom in correspondence with the ball 131a, and may be formed to be inclined outwardly corresponding to the insertion hole 131b formed at the edge portion. Here too, the fixing hole 171b formed at the edge portion for the convenience of manufacturing may be constantly adjusted to 10 degrees corresponding to the insertion hole 131b.

Finally, the lower portion of the bottom plate 130, a sealing portion 160 for sealing the cavity 110a of the phantom 110 is installed so that the filling 111 does not leak to the outside. The sealing unit 160, as shown in Figure 7, the material may be made in the form of a rubber plate using a soft rubber to perform the role of rubber packing.

As described above, according to the embodiment of the present invention, it is possible to simulate the tumor that is the target of the actual radiation surgery, and by using the gel measuring instrument 120 that can confirm the three-dimensional radiation distribution of the radiotherapy plan before treatment Since it can be used as a three-dimensional verification tool, it is possible to use the three-dimensional volume and the three-dimensional space in a three-dimensional space (target lesion) as close as possible to the actual radiation surgery environment. Verification results can be provided.

Although the present invention has been described with reference to the embodiments shown in the drawings, this is merely exemplary, and it will be understood by those skilled in the art that various modifications and equivalent other embodiments are possible. Therefore, the true technical protection scope of the present invention will be defined by the technical spirit of the appended claims.

100: verification device 110: phantom
111: Fill 120: Gel Meter
130: bottom plate 140: receiving portion
150 connection part 160 sealing part
170: auxiliary fixing part

Claims (6)

An anatomical phantom (110) having a shape of a head of a human body, having a lower opening and a hollow cavity (110a) formed therein, and having radiation permeability;
A liquid filler 111 filling the cavity 110a of the phantom 110;
A plurality of gel measuring devices 120 arranged to correspond to the verification target positions to simulate each lesion (tumor) and made of muscle equivalents in a gel state;
A bottom plate 130 installed in an opening formed at a lower portion of the phantom 110, and having a plurality of insertion holes 131 corresponding to the number thereof in the gel measuring unit 120;
A plurality of accommodating parts 140 accommodating the gel meter 120 therein and having radiation permeability;
A plurality of connection parts 150 having one end inserted into the insertion hole 131 of the bottom plate 130 and the other end connected to the accommodation part 140; And
Is installed in the lower portion of the bottom plate 130, the stereotactic radiosurgery surgery having a sealing portion 160 for sealing the cavity (110a) of the phantom 110 so that the filler 111 does not leak to the outside Verification device of target point and radiation distribution. The method according to claim 1,
The upper surface 141 of the receiving portion 140, a device for verifying the target point and radiation distribution of the brain stereotactic radiosurgery formed with a fine hole (141a) for injecting or ejecting the components of the gel measuring instrument 120 through a medical syringe. The method according to claim 1,
The muscle equivalent of the gel measuring unit 120, gelatin (Gelatin), methacrylic acid (Methacrylic acid), and water (H2O) verification device for verifying the target point and radiation distribution of brain stereotactic radiosurgery. The method according to any one of claims 1 to 3,
Apparatus for verifying the target point and the radiation distribution of the brain stereotactic radiosurgery further comprising a plate-shaped auxiliary fixing portion 170 is formed with a plurality of fixing holes 171 to insert the connecting portion 150, respectively, the position is fixed . The method of claim 4,
Among the insertion holes 131 formed in the bottom plate 130,
Insertion hole 131a formed in the inner side is formed to be perpendicular to the floor,
Insertion hole (131b) formed in the edge portion is the verification device of the target point and the radiation distribution of the brain stereotactic radiosurgery formed to be inclined outward in a direction perpendicular to the floor. The method according to claim 5,
Of the fixing holes 171 formed in the auxiliary fixing part 170,
The fixing hole 171a formed on the inner side is formed to be perpendicular to the bottom in correspondence with the insertion hole 131a formed on the inner side.
Fixing hole (171b) formed in the edge portion is the verification device of the target point and the radiation distribution of the brain stereotactic radiosurgery formed to be inclined outward corresponding to the insertion hole (131b) formed in the edge portion.

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