KR20110062519A - Compounds for dental bleaching - Google Patents

Abstract

PURPOSE: A tooth whitening composition is provided to be applied to all people without harmful organic solvent and to enable uniform whitening effect. CONSTITUTION: A tooth whitening composition contains organic acid containing calcium, phosphate ion, and carboxyl group, and soluble polymers. The soluble polymer is soluble chitosan, pollulan, sodium alginate, pectin, gelatin, carrageenan, xanthan gum, locust beam gum, arabia gum, guar gum, gellan gum, maltodextrin, starch(containing modified starch), hydroxypropyl, agarose, agar, and cellulose acetate phthalate. The composition additionally contains 0.001-5% of anti-plaque agent, anti-bad breathing agent, antibacterial agent, perfume, and sweetener.

Description

Compounds for Dental Whitening {Compounds for Dental Bleaching}

Discoloration of teeth is an endogenous factor that is colored by food waste, coffee, tea, etc. deposited on the dentin of teeth, colored by tartar or pigment components, bleeding of other colored bacteria or gingiva, and excessive intake of fluorine. This can occur if you have excessive dental nerve abnormalities or overdose with tetracycline antibiotics.

Recently, with increasing interest in cosmetology, interest in teeth whitening has increased, and various methods of discoloration treatment of teeth have been developed. Among them, temporary methods for applying a jacket crown to teeth, surgical methods such as scaling, expensive methods, and inexpensive gel- or patch-based whitening agents containing whitening ingredients that can be performed by individuals are proposed.

Professional teeth whitening programs provided by dentists include whitening treatments in the office and whitening treatments outside the treatment room. In-room treatment begins with the manufacture of a rubber dam that is specifically fitted in the mouth to prevent the whitening agent, typically hydrogen peroxide, from coming into contact with the oral soft tissue. The out-of-office whitening program differs in that the patient uses a low-intensity whitening agent over several hours a day for a long period of time, usually several weeks, so that the patient puts the whitening agent on his or her teeth. As such, a tooth whitening agent for tooth whitening has been proposed as a gel type product or a multilayer patch type product containing peroxides, metal chlorites, perborates, percarbonates, peroxides or mixtures thereof and organic solvents as tooth whitening active substances. .

However, the use of organic solvents irritates the oral mucosa and is generally used for patients with oral cancer, those with oral inflammation, those with a syringe, or those with an allergic reaction to peroxides. This is limited. In Korea, the weight ratio of peroxide in toothpaste products is regulated to 0.75% in relation to cancer and other safety issues. In addition, the use of whitening actives physically wears or chemically irritates the surface of the teeth, making them susceptible to pain or pain if they are not used. have. There is also a disadvantage that all products must be removed after use.

The present invention relates to the preparation of a tooth whitening agent that does not contain peroxides, metal chlorites, perborates, percarbonates, peroxides, or mixtures thereof or organic solvents that are harmful to the human body, which are whitening active substances exhibiting irritation to teeth. May cause harm to the human body, such as irritation of the skin, conversion to susceptible teeth that cause pain or irritation of the teeth, or may be used regardless of allergic reactions to oral cancer patients, oral inflammation, acute infections, sensitive teeth, or peroxides. To prepare a composition for whitening teeth.

 In order to achieve the above object, the present invention is characterized in that the pH is 5.0 to 9.0 containing an organic acid containing calcium and phosphate ions, a carboxyl group and 0.01 to 90% by weight water-soluble polymer. According to the present invention, the tooth whitening composition causes the calcium phosphate compound to be formed on the tooth surface by the reaction of the contained calcium ions and phosphate ions.

First, a substance containing calcium and a substance containing phosphoric acid are dissolved in an aqueous solution containing an organic acid containing a carboxyl group. When a substance containing calcium ions and phosphate ions is dissolved in an aqueous solution, the highly reactive calcium ions and phosphate ions react to form a calcium phosphate compound, so that they are dissolved in an organic acid containing a carboxyl group for stability. In addition, when the carboxyl group is included, calcium ions and phosphate ions react rapidly to prevent the formation of calcium phosphate compounds. At this time, the molar concentration of organic acid containing calcium, phosphate ions and carboxyl groups is 0.001 ~ 0.3M, the molar concentration of calcium ions and phosphate ions is 0.005 ~ 0.03M, and the molar concentration of organic acid containing carboxyl groups is 0.05 ~ 0.1M. desirable. An alkaline aqueous solution is added to an aqueous organic acid solution containing calcium ions and phosphate ions to adjust the pH to 5.0-9.0 which hardly causes oral irritation, and most preferably pH 6.5-7.5.

Weight ratio [(water soluble polymer weight / solution weight) x 100 in an aqueous solution containing calcium, phosphate ions, and an organic acid containing a carboxyl group in order to prepare a tooth whitening composition in the form of a liquid, gel or ointment topical coating of the present invention. ] Is dissolved in a water-soluble polymer so that 0.01 ~ 90%. At this time, the weight ratio of the most preferable water-soluble polymer is 0.1 to 5%. Water-soluble polymers include water-soluble chitosan, pullulan, sodium alginate, pectin, gelatin, carrageenan, xanthan gum, locust bean gum, gum arabic, guar gum, gellan gum, maltodextrin, starch (including modified starch), low viscosity alginic acid, hydroxypropyl A single substance or a mixture of cellulose derivatives such as agarose, eudragit, agar, cellulose and low viscosity hydroxypropylketylcellulose, hydroxypropylmethylcellulose phthalate, cellulose acetate phthalate, and the like can be used. When the water-soluble polymer is dissolved in an aqueous solution of pH 5.0 to 9.0 containing calcium ions and phosphate ions, it is possible to prevent sudden reaction of calcium and phosphate ions by the water-soluble polymer. When the tooth whitening composition of the present invention is applied to the teeth, the water-soluble polymer is dissolved by conditions in the oral cavity (acupuncture, degrading enzyme, pH, etc.), and at this time, calcium ions and phosphate ions are deposited on the tooth surface and react with each other. A calcium phosphate compound is applied to the tooth surface. As this reaction is repeated, the whitening of the teeth is increased, and calcium phosphate is deposited in the micropores between the teeth, thereby improving the sensitive teeth.

In addition, the tooth whitening composition of the present invention may contain anti-plaque, anti-oral, anti-gingivitis, antibacterial, caries, flavoring, sweetening and the like. A strong bactericidal effect that prevents plaque formation and prevents gingivitis with strong bactericidal action. It can be added so as to be 0.001 ~ 5% and 0.01 ~ 0.3% is most preferred. In addition to the above components, anti-plaque, bad breath, gingivitis, antibacterial, tooth decay, flavoring, sweetening and the like can be added in a weight ratio of 0.001 ~ 0.3%, respectively.

Moreover, in the case of the whitening composition, calcium phosphate is formed on the tooth surface by reaction between calcium and phosphate ions, and the calcium phosphate formed therein has a physical and chemical property capable of supporting drugs. Therefore, since calcium phosphate is coated on the whitening surface while the drug contained in the whitening composition is supported, the function of the drug on the tooth surface can be exhibited for a certain period of time, which also includes the function as a drug carrier.

The present invention can be used by everyone because it does not contain a whitening active substance exhibiting tooth irritation or an organic solvent harmful to the human body. In addition to the whitening of the teeth as well as the effect of coating the surface of the tooth with calcium phosphate as a component of the tooth is formed in the fine pores of the tooth surface, the same calcium phosphate microcrystals are formed to help the health of the teeth. In addition, it is possible to obtain a uniform whitening effect of the teeth regardless of the size of the individual teeth, there is an advantage that does not need to be removed after use.

Example 1

1000 ml of 0.05 M Acetic Acid solution is prepared. In the solution, calcium nitrate is quantified to have a calcium ion concentration of 0.02M, and diammonium phosphate is quantified to be dissolved at a concentration of 0.012M. 2 g of water-soluble chitosan was quantified and dissolved in the dissolved aqueous solution to prepare a composition for tooth whitening.

Claims (5)

In the composition for tooth whitening, the composition for tooth whitening which is pH 5.0-9.0 containing calcium and phosphate ion, the organic acid containing a carboxyl group, and a water-soluble polymer. The method of claim 1, wherein the water-soluble polymer is water-soluble chitosan, pullulan, sodium alginate, pectin, gelatin, carrageenan, xanthan gum, locust bean gum, gum arabic, guar gum, gellan gum, maltodextrin, starch (including modified starch), low viscosity Water-soluble polymers such as alginic acid, hydroxypropyl, agarose, eudragit, agar, cellulose and cellulose derivatives such as low viscosity hydroxypropylketylcellulose, hydroxypropylmethylcellulose phthalate, cellulose acetate phthalate are included as one or a mixture Tooth whitening composition, characterized in that The composition for tooth whitening according to claim 1, wherein each molar concentration of the organic acid including calcium ions, phosphate ions and carboxyl groups is 0.001 to 0.3M. The composition for teeth whitening according to claim 1, which contains a water-soluble polymer in a weight ratio of 0.01 to 90%. The composition for tooth whitening according to claim 1, wherein the anti-plaque, bad breath, gingivitis, antibacterial, caries, flavoring and sweetening agents comprise 0.001% to 5% by weight.