KR20100078325A - Purine mimics containing self-assembled brush polyether-based polymers for bio-applications, preparation thereof products comprising the polymer - Google Patents

Abstract

PURPOSE: Purine mimics containing self-assembled brush polyether-based polymers are provided to be manufactured into a molded product having various shapes due to excellent workability and to show self-assembly phenomenon in which a functional group is aligned to direction perpendicular to a substrate. CONSTITUTION: Purine mimics containing self-assembled brush polyether-based polymer are marked by chemical formula 1. In the chemical formula 1, ρ and σ show a repeating unit of carbon including R1 and R2. In the chemical formula 1, R1 and R2 are hydrogen or an alkyl group having a carbon number of 1-20 and m and n are a content(mol%) of a polyether monomer. In the chemical formula 1, m and n satisfy the condition of 0<m<=100, 0<=n<100, and m + n = 100.

Description

PURINE MIMICS CONTAINING SELF-ASSEMBLED BRUSH POLYETHER-BASED POLYMERS FOR BIO-APPLICATIONS, PREPARATION THEREOF PRODUCTS COMPRISING THE POLYMER}

The present invention relates to the synthesis and application of a self-assembling polymer material having a purine mimic at the brush end. Invented polymers can be applied as an application for inducing adsorption or separation of substances such as microorganisms, proteins, DNA and RNA, and as a substance for delivering the biological substance to a target organism using such adsorption properties.

As a method for forming a self-assembly layer, the most popular method so far is a method using a self-assembled monolayer (SAM). This method introduces a functional monomolecular material with self-assembly onto the substrate surface to produce a surface of desired properties. However, SAM has a weakness in chemical and thermal stability due to its manufacturing principle, which makes it difficult to apply to various environments.

The present invention is to make an economical polymer material that can overcome the disadvantages of the above-described SAM. The self-assembled polymer can not only effectively culture microorganisms through surface adsorption but also can be used as a medium for attaching or separating specific substances such as proteins, DNA, RNA, or delivering such substances to organisms.

In order to achieve the above technical problem, the present invention provides a self-assembling polymer compound having a purin mimic represented by the formula (1) as a brush end.

(1)

(One)

Where ρ and σ represent repeating units of carbon comprising R ₁ and R ₂ and are values of 1 to 20 regardless of each other;

R ₁ and R ₂ are each independently hydrogen, an alkyl group having 1 to 20 carbon atoms;

  m and n represent the content (mol%) of the polyether unit, where 0 <m ≦ 100, 0 ≦ n <100, and m + n = 100;

 Y is H, an alkyl group having 1 to 20 carbon atoms, or a ring containing E, G, J, L, M, Q, T, U, V, W, α, β, and γ at the -Z end;

Z is a linker,

E, G, J, L, M, Q and T are selected from the group consisting of C, N, O, P or S;

U, V, W, α, β and γ are -CHO, -COOH, -COOR, -C = NR, -H, -N ₃ , -NO ₂ , -N = R, -NH ₂ , -NHR, -NR ₂ , -NR ₃ ⁺ , -OH, -OCR, -OR, -POH, -P0R, -PO ₂ H, -PO ₂ R, -PO ₃ H, -PO ₃ R , -SH, -SR, -SOH, -SOR, -S0 ₂ H, -S0 ₂ R, -SO ₃ H, SO ₃ R, = O, = N, = S and -C ₆ H ₅ from the group consisting of Selected;

The weight average molecular weight of the mercury ion detection function brush polymer compound is 5,000 to 5,000,000, preferably 5,000 to 500,000.

In the present invention, the linker connecting the end ring and the polyether polyol main chain may be formed in various forms. In the present invention, the linker is -CH ₂ S (CR ₃ R ₄ ) _γ O-, -CH ₂ S (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -CH ₂ S (CR ₃ R ₄ ) _γ OCO-, -CH ₂ S (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ S (CR ₃ R ₄ ) _γ COO-, -CH ₂ S (CR ₃ R _{4) γ COO (CR 5 R} 6) τ -, -CH 2 S (CR 3 R 4) γ NHCO-, -CH 2 S (CR 3 R 4) γ NHCOO (CR 5 R 6) τ -, -CH ₂ S (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ S (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ S ( CR ₃ R ₄ ) _γ CO-, -CH ₂ S (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ O-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ OCO-, -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _{τ -, -CH 2 SO (CR 3} R 4) γ COO-, -CH 2 SO (CR 3 R 4) γ COO (CR 5 R 6) τ -, -CH 2 SO (CR 3 R 4) γ NHCO- , -CH ₂ SO (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ CO-, -CH ₂ SO (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ COO-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ COO (CR ₅ R _{6 ) τ -, -CH 2 SO 2} (CR 3 R 4) γ NHCO-, -CH 2 SO 2 (CR 3 R 4) γ NHCO (CR 5 R 6) τ -, -CH 2 SO 2 (CR 3 R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R _{4 ) γ CO-, -CH 2 SO 2} (CR 3 R 4) γ CO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ O-, -OCO (CR 3 R 4) γ O ( _{CR 5 R 6) τ -,} -OCO (CR 3 R 4) γ OCO-, -OCO (CR 3 R 4) γ OCO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ COO- _{, -OCO (CR 3 R 4)} γ COO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ NHCO-, -OCO (CR 3 R 4) γ NHCO (CR 5 R 6) τ - _{, -OCO (CR 3 R 4)} γ OCO (CH 2) 2 OCO-, -OCO (CR 3 R 4) γ OCO (CH 2) 2 OCO (CR 5 R 6) τ -, -OCO (CR 3 R _{4) γ CO-, -OCO (CR} 3 R 4) γ CO (CR 5 R 6) τ -, -COO (CR 3 R 4) γ O-, -COO (CR 3 R 4) γ O (CR 5 R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ OCO-, -COO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ COO-,- COO (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _{γ NHCO-, -COO (CR 3 R 4} ) γ NHCO (CR 5 R 6) τ -, -COO (CR 3 R 4) γ OCO (CH 2) 2 OCO-, -COO (CR 3 R 4) γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ CO-, -COO (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ O-, -O (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ OCO-, -O (CR ₃ R ₄ ) _γ OCO ( _{CR 5 R 6) τ -,} -O (CR 3 R 4) γ COO-, -O (CR 3 R 4) γ COO (CR 5 R 6) τ -, -O (CR 3 R 4) γ NHCO- , -O (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -O (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ CO-, -O (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ O-, -NH (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ OCO-, -NH (CR ₃ R ₄ ) _γ OCO (CR _{5 R 6) τ -, -NH (} CR 3 R 4) γ COO-, -NH (CR 3 R 4) γ COO (CR 5 R 6) τ -, -NH (CR 3 R 4) γ NHCO-, - NH (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -NH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ CO-, -NH (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ -,-(CR ₃ R _{4) γ O-, - (CR} 3 R 4) γ O (CR 5 R 6) τ -, - (CR 3 R 4) γ OCO-, - (CR 3 R 4) γ OCO (CR 5 R 6) _τ -,-(CR ₃ R ₄ ) _γ (CH ₂ ) _n COO-,-(CR ₃ R ₄ ) _γ (CH ₂ ) _n COO (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ NHCO-,-(CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-,-(CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ O-, -OC ₆ H ₄ (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ -,- OC ₆ H ₄ (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _{τ- , -OC 6 H 4 (CR 3} R 4) γ NHCO-, -OC 6 H 4 (CR 3 R 4) γ NHCO (CR 5 R 6) τ -, -OC 6 H 4 (CR 3 R 4) γ -, -OCO (CH ₂ ) ₂ OCO-, -OCO (CH ₂ ) ₂ OCO (CR ₃ R ₄ ) _γ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ ( CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ COO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ O-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -OC ₆ H _{4 COO (CR 3 R 4)} γ NHCO-, -OC 6 H 4 COO (CR 3 R 4) γ NHCO (CR 5 R 6) τ -, -OC 6 H 4 COO (CR 3 R 4) γ OCO ( CH ₂ ) ₂ OCO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ CO -, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ -or -OC ₆ H ₄ CONHR (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ CONHR (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ COO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ O-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR _{3 R 4) γ NHCO-, -OC} 6 H 4 CONH (CR 3 R 4) γ NHCO (CR 5 R 6) τ -, -OC 6 H 4 CONH (CR 3 R 4) γ OCO (CH 2) 2 OCO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ − may be an aliphatic or aromatic derivative selected from the group consisting of wherein γ and τ are each independently of each other R ₃ and R ₄ and, including R ₅ and R ₆ As carbon repeating units has a value of 1 to 20 carbon atoms, R _3, R _4, R ₅ and R ₆ is an alkyl group of a hydrogen, 1 to 20 carbon, regardless of each other.

In a preferred embodiment of the invention, the linker is formed by an ester reaction, preferably -CH ₂ S (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- In the ring, T, G, M and L are elements N and E, J and Q are elements C.

  As a representative example of the purine mimic self-assembling brush polymer compound of formula 1 according to the present invention, poly [oxy ((adenineethyloxycarbonylethylcarbonyloxy) undecylthiomethyl) ethylene-lan- having a structure of formula (2) Oxy (dodecylthiomethyl) ethylene] (hereinafter abbreviated as PECH-A).

(2)

(2)

Wherein m and n are as defined in the formula (1).

  In the self-assembling polymer compound having the purine mimic of Chemical Formula 1 as a brush end, m representing the content (mol%) of the brush polymer compound unit is 0 to 100, preferably 50 to 100.

The polymer compound according to the present invention has a flexible brush property that, upon coating, orients in layers over a large area perpendicular to the surface on which the functional groups at the end are coated. This orientation can maximize the efficacy of the side chain functional groups.

The present invention in one aspect, the polyether polymer represented by the following formula (3)

(3)

(3)

The compound of formula 4 in an organic solvent

(4)

(4)

Or through the reaction with derivatives thereof to prepare a compound of formula (1),

Here, L1 and L2 are linkers forming the W of the formula (1) through a reaction,

Y1 is hydrogen, a C1-C20 alkyl group, or L1.

In the present invention, the reaction is a polyether polymer having a polyether polymer of formula 3 is reacted with a compound of formula 4 in an organic solvent, the layer is oriented in a layer over a large area perpendicular to the surface coated with functional groups at the time of coating To prepare. Organic solvents to be used include chloroform, dichloromethane, dimethylacetamide, dimethylformamide or a mixed solution thereof.

In one embodiment of the present invention, when the linker of Formula 1 is coated, Z, which is oriented in a layer structure over a large area perpendicular to a surface coated with functional groups at the terminal, is formed in the linkers L1 and T of the polyether polymer compound of Formula 3 It can be prepared by the reaction of linker L2, for example L1 is -OH terminal, ester condensation reaction as L2 acid group.

In a preferred embodiment of the present invention, the linker L2 of Chemical Formula 4 may introduce an alcohol group, and then react with an enhydride compound to convert the terminal into -COOH. In the present invention, the polyether polymer compound of the general formula (3) of the OH terminal can be prepared through a halogen substitution reaction to the polyether compound of the general formula (5).

(5)

(5)

Wherein R1 and R2 are hydrogen or alkyl of 1-20 carbon atoms, γ is a repeating unit of 0-20 integer, and x is F, Cl, Br And I, d is 50 to 50,000 and A is hydrogen, alkyl, or CH2X.

In the practice of the present invention, the halogen substitution reaction may be introduced by reacting a CH2X group with a mixture of NaSROH and NaSR, wherein R and ROH are alkyl having 1-20 carbon atoms, and alkoxy. Examples of the solvent include dimethylacetamide, dimethylformamide, diethyl ether, dichloromethane, tetrahydrofuran or a mixed solution thereof. The reaction in this step is preferably carried out at a temperature of -100 to 100 ℃ and a pressure of # 1 to 5 atm.

The polyether high molecular compound of Formula (5) can be prepared by a known method, the triphenylcarbenium hexa in a solvent such as dichloromethane, chloroform, diethyl ether, without using a cyclic ether compound or a solvent Cation ring-opening polymerization in the presence of a cationic initiator such as fluorophosphate or triphenylcarbenium hexachloroantimoniate, alkyl aluminum, and the like.

In one aspect, the present invention provides a use of a polymer having a purine mimic represented by Chemical Formula 1 as a brush end as a biocompatible material.

In the present invention, the polymer compound has a biocompatibility as a material, has the ability to adhere, adsorb, or improve adhesion to cells, and has an ability to inhibit adhesion, adsorption, or adhesion to pathogenic bacteria.

In the practice of the present invention, the biocompatible brush polymer exhibits an improvement in adsorption, adhesion, or adhesion to HEp-2 cells, and the like. P.aeruginosa, S.aureus, S. epidermidis, E. faecalis, or Inhibition of adhesion, adhesion, or adhesion to pathogenic bacteria such as E. coli . Accordingly, the biocompatible polymer according to the present invention can be used as a biocompatible material for preparing or coating various types of workpieces, such as teeth, artificial joints, implants, etc., which are inserted or administered in vivo. .

In one aspect, the present invention provides a use as a sensor or an adsorption or separation agent using a selective binding property to the protein of the brush polymer having a purin mimic represented by the formula (1) at the brush end.

The polymer compound according to the present invention has a good binding property with a protein, so that the protein can be selectively adsorbed and used as a protein separation or purification material. For example, the coating film made of a polymer according to the present invention may be selectively adsorbed to gamma-globulin.

The polymer compound according to the present invention can be used as a chemical sensor that can detect proteins. For example, the polymer according to the present invention can be prism surface coated and the protein can be detected through plasmon resonance spectroscopy. In the practice of the present invention, the detection of the protein or the detection of a specific protein can be made by measuring the change in reflectivity according to the binding of the protein by injecting light into the prism coated with the polymer compound using a surface plasmon resonance spectroscopy.

According to the present invention, there is provided a brush-like polyether polymer having a side chain having a purinmimic group at its end.

Purinmimic brush polymer according to the present invention can be produced in a variety of moldings on the basis of the excellent processability, especially when the functional group is oriented in a direction perpendicular to the substrate when made of a nano film on a specific substrate Self-assembly Self-assembly maximizes the surface distribution of functional groups, which can maximize the interaction of functional groups bound to the ends of the polymeric material with materials such as cells, proteins, DNA and RNA. Using these characteristics, the self-assembled polymer can not only effectively culture microorganisms through surface adsorption, but also can be used as a medium for attaching or separating specific substances such as proteins, DNA, RNA, or delivering such substances to living organisms. This is possible.

Hereinafter, the present invention will be described with reference to the following synthesis examples and examples, but the present invention is not limited only to the following synthesis examples and examples.

Synthesis Example 1

40 mL (512 mmol) of epichlorohydrin was added to a 100 mL round bottom flask and cooled to 5 ° C. under a nitrogen atmosphere. A solution of 2.56 mmol of an initiator dissolved in dichloromethane was added thereto, followed by stirring at room temperature for 4 days. The reaction product was dissolved in a small amount of dichloromethane, purified by reprecipitation in methanol, and dried for 8 hours under vacuum at 40 ° C. to prepare polyepichlorohydrin. Yield 65%. ¹ H-NMR (300 MHz, CDCl ₃ ): δ (ppm) = 3.89-3.49 (br, 3H, OCH, OCH ₂ , CH ₂ Cl); ¹³ C-NMR (75 MHz, CDCl ₃ ): δ (ppm) = 79.70, 70.32, 44.31; FTIR (in film): ν (cm ⁻¹ ) = 2960, 2915, 2873, 1427, 1348, 1299, 1263, 1132, 750, 707.

Synthesis Example 2 (m = 0, PECH_OH0)

To a solution of 558 mg (6.03 mmol) of polyepichlorohydrin compound obtained in Synthesis Example 1 in 5 mL of dimethylacetamide, a solution of 1350 mg (6.03 mmol) of sodium dodecylthiolate in 10 mL of dimethylacetamide was added. . The mixture was stirred at 50 ° C. for 2 hours, extracted with chloroform, washed with water to remove the solvent, and then precipitated in hexane. This precipitate was dried under vacuum at 40 ° C. for 8 hours to obtain the title compound (PECH_OH0). ¹ H-NMR (300 MHz, CDCl ₃ ): δ (ppm) = 3.70-3.59 (br, 3H, OCH, OCH ₂ ), 2.75-2.52 (m, 4H, CH ₂ SCH ₂ ), 1.57-1.13 (m , 20H, CH ₂ ), 0.88 (t, 3H, CH ₃ ); ¹³ C-NMR (75 MHz, CDCl ₃ ): δ (ppm) = 79.36-78.72, 63.07, 39.23, 33.26, 32.82, 29.75-28.53, 25.76; IR (in film): ν (cm ⁻¹ ) = 2960, 2854, 1460, 1110, 732.

Synthesis Example 3 (m = 25, PECH_OH25)

894 mg (9.66 mmol) of the polyepichlorohydrin compound obtained in Synthesis Example 1 was dissolved in 6 mL of dimethylacetamide, 548 mg (2.42 mmol) of sodium 11-hydroxyundecylthiolate and 1630 mg of sodium dodecylthiolate. (7.25 mmol) was added to a solution of 30 mL of dimethylacetamide. The mixture was stirred for one day at room temperature, extracted with chloroform, washed with water to remove the solvent, and then precipitated in hexane. This precipitate was dried under vacuum at 40 ° C. for 8 hours to obtain the title compound (PECH_OH20). ¹ H-NMR (300 MHz, CDCl ₃ ): δ (ppm) = 3.70-3.59 (br, OCH, OCH ₂ ), 2.75-2.52 (m, CH ₂ SCH ₂ ), 1.57-1.13 (m, CH ₂ ) , 0.88 (t, CH ₃ ); ¹³ C-NMR (75 MHz, CDCl ₃ ): δ (ppm) = 79.36-78.72, 69.42, 63.07, 39.23, 33.26, 32.82, 29.75-28.53, 25.76, 23.31, 14.75; IR (in film): ν (cm ⁻¹ ) = 3590-3100, 2960, 2854, 1460, 1110, 732.

Synthesis Example 4 (m = 50, PECH_OH50)

894 mg (9.66 mmol) of the polyepichlorohydrin compound obtained in Synthesis Example 1 was dissolved in 6 mL of dimethylacetamide. mmol) was added to 30 mL of dimethylacetamide. The mixture was stirred for one day at room temperature, extracted with chloroform, washed with water to remove the solvent, and then precipitated in hexane. This precipitate was dried under vacuum at 40 ° C. for 8 hours to obtain the title compound (PECH_OH40). ¹ H-NMR (300 MHz, CDCl ₃ ): δ (ppm) = 3.70-3.59 (br, OCH, OCH ₂ ), 2.75-2.52 (m, CH ₂ SCH ₂ ), 1.57-1.13 (m, CH ₂ ) , 0.88 (t, CH ₃ ); ¹³ C-NMR (75 MHz, CDCl ₃ ): δ (ppm) = 79.36-78.72, 69.42, 63.07, 39.23, 33.26, 32.82, 29.75-28.53, 25.76, 23.31, 14.75; IR (in film): ν (cm ⁻¹ ) = 3590-3100, 2960, 2854, 1460, 1110, 732.

Synthesis Example 5 (m = 75, PECH_OH75)

In a solution of 894 mg (9.66 mmol) of the polyepichlorohydrin compound obtained in Synthesis Example 1 in 6 mL of dimethylacetamide, 1630 mg (7.25 mmol) of 11-hydroxyundecylthiolate and 542 mg of dodecylthiolate (2.41 mmol) was added to 30 mL of dimethylacetamide. The mixture was stirred for one day at room temperature, extracted with chloroform, washed with water to remove the solvent, and then precipitated in hexane. This precipitate was dried under vacuum at 40 ° C. for 8 hours to obtain the title compound (PECH_OH60). ¹ H-NMR (300 MHz, CDCl ₃ ): δ (ppm) = 3.70-3.59 (br, OCH, OCH ₂ ), 2.75-2.52 (m, CH ₂ SCH ₂ ), 1.57-1.13 (m, CH ₂ ) , 0.88 (t, CH ₃ ); ¹³ C-NMR (75 MHz, CDCl ₃ ): δ (ppm) = 79.36-78.72, 69.42, 63.07, 39.23, 33.26, 32.82, 29.75-28.53, 25.76, 23.31, 14.75; IR (in film): ν (cm ⁻¹ ) = 3590-3100, 2960, 2854, 1460, 1110, 732.

Synthesis Example 6 (m = 100, PECH_OH100)

500 mg (5.4 mmol) of the polyepichlorohydrin compound obtained in Synthesis Example 1 was dissolved in 2 mL of dimethylacetamide, and 1,382 mg (5.4 mmol) of 11-hydroxyundecylthiolate was dissolved in 10 mL of dimethylacetamide. The solution was added. The mixture was stirred at room temperature for 2 hours, extracted with chloroform, washed with water to remove the solvent, and then precipitated in hexane. This precipitate was dried under vacuum at 40 ° C. for 8 hours to obtain the target compound (PECH_OH100). ¹ H-NMR (300 MHz, CDCl ₃ ): δ (ppm) = 3.70-3.59 (br, 3H, OCH, OCH ₂ ), 2.75-2.52 (m, 4H, CH ₂ SCH ₂ ), 1.57-1.13 (m , 18H, CH ₂ ); ¹³ C-NMR (75 MHz, CDCl ₃ ): δ (ppm) = 79.36-78.72, 69.42, 63.07, 39.23, 33.26, 32.82, 29.75-28.53, 25.76; IR (in film): ν (cm ⁻¹ ) = 3590-3100, 2960, 2854, 1460, 1110, 732.

Synthesis Example 7 6- (9-Adenyl) ethyloxycarbonylethylcarbosnic acid (synthesis of derivative of Synthesis Example 6)

4.96 g (36.7 mmol) of adenine, ethylene carbonate (3.30 g, 37.5 mmol) and traces of sodium hydroxide are dissolved in 150 ml of dimethylformamide and then refluxed for 2 hours. After the reaction, the solvent was removed by heating under reduced pressure, and the remaining material was recrystallized from ethanol. 4.68 g (yield = 71%) of 9- (2-hydroxyethyl) adenine are obtained. ¹ H NMR (DMSO- d ) 8.15 (1 H, s), 8.08 (1 H, s), 7.24 (2 H, s), 5.00 (1 H, t), 4.19 (2 H, t), 3.75 ( 2 H, q). 0.50 g (2.79 mmol) of 9- (2-hydroxyethyl) adenine and 0.279 (2.79 mmol) of succinyl anhydride were dissolved in 20 ml of dimethylformamide, and then reacted at room temperature for 24 hours. After the reaction was completed, the white precipitated material was filtered off, washed with diethyl ether several times and dried to obtain 0.59 g (yield = 80%) of 6- (9-adenyl) ethyloxycarbonylethylcarbonyl acid. ¹ H NMR (DMSO- d ) 8.14 (1 H, s), 8.13 (1 H, s), 7.21 (2 H, s), 4.39 (4 H, t), 2.43 (4 H, t).

Synthesis Example 8 (m = 25, PECH-A25)

260 mg (0.25 OH mmol) of the compound obtained in Synthesis Example 3 and 116 mg (0.750 mmol) of 4-N- (3-dimethylaminopropyl) -N'-ethylcarbodiimide hydrochloride, 46 mg of 4- (dimethylamino) pyridine (0.375 mmol) and 66 mg (0.25 mmol) of the compound obtained in Synthesis Example 7 were dissolved in 20 ml dimethylformamide, and then stirred with heating at 50 ° C. for 24 hours. After the reaction was completed, the mixture was cooled to room temperature, precipitated in 200 ml of diethyl ether, the precipitated solvent was removed, and the remaining solid was purified by silica gel chromatography (methylene chloride: methanol = 20 vol%: 80 vol%, R _f = 0.8). ¹ H-NMR (300 MHz, DMSO- d ) 8.12 (s, 1H, NH), 8.09 (s, 1H, Ar-H), 7.21 (s, 2H, NH ₂ ), 4.37 (t, 4H, NCH ₂ CH ₂ O), 4.08 (s, 2H, CH ₂ ), 3.70-3.59 (br, 3H, OCH, OCH ₂ ), 2.81-2.54 (t, 4H, CH ₂ SCH ₂ ), 2.48 (t, 4H, OCCH ₂ CH ₂ CO), 1.67-1.13 (m, 18H, CH ₂ ), 0.88 (t, 3H, CH ₃ ); ¹³ H-NMR (75 MHz, DMSO- d ) 172.7, 155.9, 152.3, 149.3, 140.8, 118.7, 79.36-78.72, 64.9, 63.2, 61.6, 42.9, 33.6, 32.5, 30.3-27.3, 26.5-24.7, 14.75; IR (KBr) ν (cm ^-1 ) = 3800-3020, 2920, 2850, 1730, 1660, 1600, 1470, 1320, 1300, 1190, 1135, 1080

Synthesis Example 8 (m = 50, PECH-A50)

260 mg (0.50 OH mmol) of the compound obtained in Synthesis Example 4 and 233 mg (1.50 mmol) of N- (3-dimethylaminopropyl) -N'-ethylcarbodiimide hydrochloride, 92 mg of 4- (dimethylamino) pyridine (0.75 mmol) and 132 mg (0.50 mmol) of the compound obtained in Synthesis Example 7 were dissolved in 20 ml dimethylformamide, and then stirred with heating at 50 ° C. for 24 hours. After the reaction was completed, the mixture was cooled to room temperature, precipitated in 200 ml of diethyl ether, the precipitated solvent was removed, and the remaining solid was purified by silica gel chromatography (methylene chloride: methanol = 20 vol%: 80 vol%, R _f = 0.8). ¹ H-NMR (300 MHz, DMSO- d ) 8.12 (s, 1H, NH), 8.09 (s, 1H, Ar-H), 7.21 (s, 2H, NH ₂ ), 4.37 (t, 4H, NCH ₂ CH ₂ O), 4.08 (s, 2H, CH ₂ ), 3.70-3.59 (br, 3H, OCH, OCH ₂ ), 2.81-2.54 (t, 4H, CH ₂ SCH ₂ ), 2.48 (t, 4H, OCCH ₂ CH ₂ CO), 1.67-1.13 (m, 18H, CH ₂ ), 0.88 (t, 3H, CH ₃ ); ¹³ H-NMR (75 MHz, DMSO- d ) 172.7, 155.9, 152.3, 149.3, 140.8, 118.7, 79.36-78.72, 64.9, 63.2, 61.6, 42.9, 33.6, 32.5, 30.3-27.3, 26.5-24.7, 14.75; IR (KBr) ν (cm ^-1 ) = 3800-3020, 2920, 2850, 1730, 1660, 1600, 1470, 1320, 1300, 1190, 1135, 1080

Synthesis Example 9 (m = 75, PECH-A75)

260 mg (0.75 OH mmol) of the compound obtained in Synthesis Example 5 and 349 mg (2.25 mmol) of N- (3-dimethylaminopropyl) -N'-ethylcarbodiimide hydrochloride, 137 mg of 4- (dimethylamino) pyridine (1.13 mmol) and 197 mg (0.75 mmol) of the compound obtained in Synthesis Example 7 were dissolved in 20 ml dimethylformamide, and then stirred with heating at 50 ° C. for 24 hours. After the reaction was completed, the mixture was cooled to room temperature, precipitated in 200 ml of diethyl ether, the precipitated solvent was removed, and the remaining solid was purified by silica gel chromatography (methylene chloride: methanol = 20 vol%: 80 vol%, R _f = 0.8). ¹ H-NMR (300 MHz, DMSO- d ) 8.12 (s, 1H, NH), 8.09 (s, 1H, Ar-H), 7.21 (s, 2H, NH ₂ ), 4.37 (t, 4H, NCH ₂ CH ₂ O), 4.08 (s, 2H, CH ₂ ), 3.70-3.59 (br, 3H, OCH, OCH ₂ ), 2.81-2.54 (t, 4H, CH ₂ SCH ₂ ), 2.48 (t, 4H, OCCH ₂ CH ₂ CO), 1.67-1.13 (m, 18H, CH ₂ ), 0.88 (t, 3H, CH ₃ ); ¹³ H-NMR (75 MHz, DMSO- d ) 172.7, 155.9, 152.3, 149.3, 140.8, 118.7, 79.36-78.72, 64.9, 63.2, 61.6, 42.9, 33.6, 32.5, 30.3-27.3, 26.5-24.7, 14.75; IR (KBr) ν (cm ^-1 ) = 3800-3020, 2920, 2850, 1730, 1660, 1600, 1470, 1320, 1300, 1190, 1135, 1080

Synthesis Example 10 (m = 100, PECH-A100)

260 mg (1.00 OH mmol) of the compound obtained in Synthesis Example 6 and 465 mg (3 mmol) of N- (3-dimethylaminopropyl) -N'-ethylcarbodiimide hydrochloride, 183 mg of 4- (dimethylamino) pyridine (1.5 mmol) and 263 mg (1.00 mmol) of the compound obtained in Synthesis Example 7 were dissolved in 20 ml dimethylformamide, and then stirred with heating at 50 ° C. for 24 hours. After the reaction was completed, the mixture was cooled to room temperature, precipitated in 200 ml of diethyl ether, the precipitated solvent was removed, and the remaining solid was purified by silica gel chromatography (methylene chloride: methanol = 20 vol%: 80 vol%, R _f = 0.8). ¹ H-NMR (300 MHz, DMSO- d ) 8.12 (s, 1H, NH), 8.09 (s, 1H, Ar-H), 7.21 (s, 2H, NH ₂ ), 4.37 (t, 4H, NCH ₂ CH ₂ O), 4.08 (s, 2H, CH ₂ ), 3.70-3.59 (br, 3H, OCH, OCH ₂ ), 2.81-2.54 (t, 4H, CH ₂ SCH ₂ ), 2.48 (t, 4H, OCCH ₂ CH ₂ CO), 1.67-1.13 (m, 18H, CH ₂ ); ¹³ H-NMR (75 MHz, DMSO- d ) 172.7, 155.9, 152.3, 149.3, 140.8, 118.7, 79.36-78.72, 64.9, 63.2, 61.6, 42.9, 33.6, 32.5, 30.3-27.3, 26.5-24.7; IR (KBr) ν (cm ^-1 ) = 3800-3020, 2920, 2850, 1730, 1660, 1600, 1470, 1320, 1300, 1190, 1135, 1080

&Lt; Example 1 >

The brush polymer described above is dissolved in a solution of 1wt% concentration using chloroform as a solvent. This solution is dip coated onto a polyethylene terephthalate substrate and dried in a 60 ° C. vacuum oven for one day. The prepared film was subjected to adsorption and sterilization experiment using five pathogenic bacteria. Experimental method is to put each polymer thin film in a medium containing five pathogenic bacteria quantified at the concentration of 10 ⁷ CFU / ml, and then the bacteria were adsorbed for 30 minutes and 2 hours, then taken out and detached by an ultrasonic wave, The inoculum was inoculated in semi-solid medium and grown in a 37 ° C. incubator for one day to calculate the amount of adsorption. The experiment is shown in Figure 1 the average value of three iterations.

<Example 2>

The brush polymer described above is dissolved in a solution of 1wt% concentration using chloroform as a solvent. The solution is dip coated onto a slide glass substrate and dried in a 60 ° C. vacuum oven for one day. The prepared polymer thin film was tested for cell compatibility using HEp-2 cells, which are human endothelial cells. The test method is to disinfect each polymer thin film with 70% ethyl alcohol and place it in a T-25 flask, and then add a HEp-2 cells suspension with 0.5 × 10 ⁶ cells / ml in a suitable medium. The behavior of HEp-2 cells on the polymer thin film was observed with time. Optical micrographs of the cells on each polymer thin film observed at 6 hours, 3 days, and 7 days are shown in FIG. 2.

<Example 3>

The brush polymer described above is dissolved in a solution of 1wt% concentration using chloroform as a solvent. The solution is spin coated onto a gold coated prism and dried in a 60 ° C. vacuum oven for one day. The polymer-coated prism was subjected to adsorption experiments on three different proteins using surface plasmon resonance spectroscopy. The concentration of each protein was adjusted to 1 mg / mL, and the change in reflectivity with adsorption is shown in FIG. 3.

1 is a graph of adsorption of bacteria over time (30 minutes, 2 hours) of the membrane used in this experiment.

FIG. 2 is a photograph of observation of cell suitability according to time using HEp-2 cells (6 hours, 3 days, 7 days) using an optical microscope.

3 is a graph of adsorption experiments for three different kinds of proteins.

4 is a two-dimensional image measuring the orientation of a polymer main chain and a brush using a Grazing Incidence X-ray Scattering (GIXS) device that analyzes a polymer thin film structure using a 4C2 beamline of a Pohang emission accelerator. The result is.

FIG. 5 is a graph result of confirming the layered structure by self-assembly of the polymer by extracting data in the vertical direction of the substrate of FIG. 4.

Claims (20)

Self-assembling brush polymer compound represented by the following formula (1).

(One) Where ρ and σ represent repeating units of carbon comprising R ₁ and R ₂ and are values of 1 to 20 regardless of each other; R ₁ and R ₂ are each independently hydrogen, an alkyl group having 1 to 20 carbon atoms;   m and n represent the content (mol%) of the polyether unit, where 0 <m ≦ 100, 0 ≦ n <100, and m + n = 100;  Y is H, an alkyl group having 1 to 20 carbon atoms, or a ring containing E, G, J, L, M, Q, T, U, V, W, α, β, and γ at the -Z end; Z is a linker, E, G, J, L, M, Q and T are selected from the group consisting of C, N, O, P or S; U, V, W, α, β and γ are -CHO, -COOH, -COOR, -C = NR, -H, -N ₃ , -NO ₂ , -N = R, -NH ₂ , -NHR, -NR ₂ , -NR ₃ ⁺ , -OH, -OCR, -OR, -POH, -P0R, -PO ₂ H, -PO ₂ R, -PO ₃ H, -PO ₃ R , -SH, -SR, -SOH, -SOR, -S0 ₂ H, -S0 ₂ R, -SO ₃ H, SO ₃ R, = O, = N, = S and -C ₆ H ₅ from the group consisting of Is selected. The method of claim 1, Z is -CH ₂ S (CR ₃ R ₄ ) _γ O-, -CH ₂ S (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -CH ₂ S (CR ₃ R ₄ ) _γ OCO- , -CH ₂ S (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ S (CR ₃ R ₄ ) _γ COO-, -CH ₂ S (CR ₃ R ₄ ) _γ COO (CR _{5 R 6) τ -, -CH} 2 S (CR 3 R 4) γ NHCO-, -CH 2 S (CR 3 R 4) γ NHCOO (CR 5 R 6) τ -, -CH 2 S (CR 3 R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ S (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ S (CR ₃ R ₄ ) _γ CO-, -CH ₂ S (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ O-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ OCO-, -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO _{(CR 3 R 4) γ COO-} , -CH 2 SO (CR 3 R 4) γ COO (CR 5 R 6) τ -, -CH 2 SO (CR 3 R 4) γ NHCO-, -CH 2 SO ( CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ CO-, -CH ₂ SO (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ -,- _{CH 2 SO 2 (CR 3 R} 4) γ COO-, -CH 2 SO 2 (CR 3 R 4) γ COO (CR 5 R 6) τ -, -CH 2 SO 2 (CR 3 R 4) γ NHCO- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ SO ₂ ( CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ CO-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ CO _{(CR 5 R 6) τ -} , -OCO (CR 3 R 4) γ O-, -OCO (CR 3 R 4) γ O (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ OCO _{-, -OCO (CR 3 R 4} ) γ OCO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ COO-, -OCO (CR 3 R 4) γ COO (CR 5 R 6) τ _{-, -OCO (CR 3 R 4} ) γ NHCO-, -OCO (CR 3 R 4) γ NHCO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ OCO (CH 2) 2 OCO- _{, -OCO (CR 3 R 4)} γ OCO (CH 2) 2 OCO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ CO-, -OCO (CR 3 R 4) γ CO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ O-, -COO (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ OCO-, -COO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ COO-, -COO (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ NHCO-, -COO (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ -,- COO (CR ₃ R ₄ ) _γ CO-, -COO (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ O-, -O (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ OCO-, -O (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _{γ COO-, -O (CR 3 R} 4) γ COO (CR 5 R 6) τ -, -O (CR 3 R 4) γ NHCO-, -O (CR 3 R 4) γ NHCO (CR 5 R 6 ) _τ- , -O (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -O (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -O ( CR ₃ R ₄ ) _γ CO-, -O (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ O-, -NH (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ OCO-, -NH (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ COO _{-, -NH (CR 3 R 4} ) γ COO (CR 5 R 6) τ -, -NH (CR 3 R 4) γ NHCO-, -NH (CR 3 R 4) γ NHCO (CR 5 R 6) τ -, -NH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -NH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ CO-, -NH (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ O-,-(CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ OCO-,-(CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ (CH ₂ ) _n COO-,- _{(CR 3 R 4) γ (} CH 2) n COO (CR 5 R 6) τ -, - (CR 3 R 4) γ NHCO-, - (CR 3 R 4) γ NHCO (CR 5 R 6) τ - ,-(CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-,-(CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ O-, -OC ₆ H ₄ (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ ( _{CR 3 R 4) γ OCO-,} -OC 6 H 4 (CR 3 R 4) γ COO (CR 5 R 6) τ -, -OC 6 H 4 (CR 3 R 4) γ NHCO-, -OC 6 H _{4 (CR 3 R 4) γ} NHCO (CR 5 R 6) τ -, -OC 6 H 4 (CR 3 R 4) γ -, -OCO (CH 2) 2 OCO-, -OCO (CH 2) 2 OCO (CR ₃ R ₄ ) _γ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ COO- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ O-, -OC ₆ H ₄ COO (CR ₃ R _{4) γ O (CR 5 R} 6) τ -, -OC 6 H 4 COO (CR 3 R 4) γ NHCO-, -OC 6 H 4 COO (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ CO ( CR ₅ R ₆ ) _τ -or -OC ₆ H ₄ CONHR (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ CONHR (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ COO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ O _{-, -OC 6 H 4 CONH (} CR 3 R 4) γ O (CR 5 R 6) τ -, -OC 6 H 4 CONH (CR 3 R 4) γ NHCO-, -OC 6 H 4 CONH (CR 3 R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ -an aliphatic or aromatic derivative selected from the group consisting of; Γ and τ are each carbon repeating unit including R ₃ and R ₄ and R ₅ and R ₆ irrespective of each other and have a value of 1 to 20 carbon atoms and R ₃ , R ₄ , R ₅ and R ₆ are A self-assembling brush polymer compound that is hydrogen or an alkyl group having 1 to 20 carbon atoms irrespective of each other. The self-assembling brush polymer compound of claim 1, wherein the brush polymer has a weight average molecular weight of 5,000 to 5,000,000. The self-assembling brush polymer compound according to claim 1, wherein T, M, L, and G are N, and Q and E are C. The method of claim 1, wherein the polymer compound A self-assembling functional brush polymer compound which is poly [oxy ((adenineethyloxycarbonylethylcarbonyloxy) undecylthiomethyl) ethylene-lan-oxy (dodecylthiomethyl) ethylene]. In the method for producing a functional brush polymer compound, a polyether polymer represented by the following formula (3)

(3) The compound of formula 4 in an organic solvent

(4) Or react with derivatives thereof, Where ρ and σ represent repeating units of carbon comprising R ₁ and R ₂ and are values of 1 to 20 regardless of each other; R ₁ and R ₂ are each independently hydrogen, an alkyl group having 1 to 20 carbon atoms;   m and n represent the content (mol%) of the polyether unit, where 0 <m ≦ 100, 0 ≦ n <100, and m + n = 100;  Y1 is H, an alkyl group having 1 to 20 carbon atoms or L1, E, G, J, L, M, Q and T are selected from the group consisting of C, N, O, P or S; U, V, W, α, β and γ are -CHO, -COOH, -COOR, -C = NR, -H, -N ₃ , -NO ₂ , -N = R, -NH ₂ , -NHR, -NR ₂ , -NR ₃ ⁺ , -OH, -OCR, -OR, -POH, -P0R, -PO ₂ H, -PO ₂ R, -PO ₃ H, -PO ₃ R , -SH, -SR, -SOH, -SOR, -S0 ₂ H, -S0 ₂ R, -SO ₃ H, SO ₃ R, = O, = N, = S and -C ₆ H ₅ from the group consisting of Selected, L1 and L2 react to form Z, and Z is -CH ₂ S (CR ₃ R ₄ ) _γ O-, -CH ₂ S (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -CH ₂ S (CR ₃ R ₄ ) _γ OCO-,- CH ₂ S (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ −, —CH ₂ S (CR ₃ R ₄ ) _γ COO-, —CH ₂ S (CR ₃ R ₄ ) _γ COO (CR ₅ R _{6) τ -, -CH 2 S} (CR 3 R 4) γ NHCO-, -CH 2 S (CR 3 R 4) γ NHCOO (CR 5 R 6) τ -, -CH 2 S (CR 3 R 4) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ S (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ S (CR ₃ R ₄ ) _γ CO- , -CH ₂ S (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ O-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ OCO-, -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR _{3 R 4) γ COO-, -CH} 2 SO (CR 3 R 4) γ COO (CR 5 R 6) τ -, -CH 2 SO (CR 3 R 4) γ NHCO-, -CH 2 SO (CR 3 R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ CO-, -CH ₂ SO (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -CH _{2 SO 2 (CR 3 R 4)} γ COO-, -CH 2 SO 2 (CR 3 R 4) γ COO (CR 5 R 6) τ -, -CH 2 SO 2 (CR 3 R 4) γ NHCO-, - CH ₂ SO ₂ (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ CO-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ CO (CR _{5 R 6) τ -, -OCO} (CR 3 R 4) γ O-, -OCO (CR 3 R 4) γ O (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ OCO-, _{-OCO (CR 3 R 4) γ} OCO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ COO-, -OCO (CR 3 R 4) γ COO (CR 5 R 6) τ -, _{-OCO (CR 3 R 4) γ} NHCO-, -OCO (CR 3 R 4) γ NHCO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ OCO (CH 2) 2 OCO-, - _{OCO (CR 3 R 4) γ} OCO (CH 2) 2 OCO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ CO-, -OCO (CR 3 R 4) γ CO (CR 5 R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ O-, -COO (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ OCO-, -COO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ COO-, -COO (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ NHCO-, -COO (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ CO-, -COO (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ O-, -O (CR ₃ R ₄ ) _γ O ( CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ OCO-, -O (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ COO- _{, -O (CR 3 R 4)} γ COO (CR 5 R 6) τ -, -O (CR 3 R 4) γ NHCO-, -O (CR 3 R 4) γ NHCO (CR 5 R 6) τ - , -O (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -O (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ CO-, -O (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ O-, -NH (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ OCO-, -NH (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ COO-,- _{NH (CR 3 R 4) γ} COO (CR 5 R 6) τ -, -NH (CR 3 R 4) γ NHCO-, -NH (CR 3 R 4) γ NHCO (CR 5 R 6) τ -, - NH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -NH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ CO-, -NH (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ O-,-(CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ OCO-,-(CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ (CH ₂ ) _n COO-,-(CR ₃ R ₄ ) _γ (CH ₂ ) _n COO (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ NHCO-,-(CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ -,- (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-,-(CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ O-, -OC ₆ H ₄ (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ (CR _{3 R 4) γ OCO-, -OC 6} H 4 (CR 3 R 4) γ COO (CR 5 R 6) τ -, -OC 6 H 4 (CR 3 R 4) γ NHCO-, -OC 6 H 4 ( _{CR 3 R 4) γ NHCO (} CR 5 R 6) τ -, -OC 6 H 4 (CR 3 R 4) γ -, -OCO (CH 2) 2 OCO-, -OCO (CH 2) 2 OCO (CR ₃ R ₄ ) _γ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ COO-,- OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ O-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _{γ O (CR 5 R 6)} τ -, -OC 6 H 4 COO (CR 3 R 4) γ NHCO-, -OC 6 H 4 COO ( CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ -or -OC ₆ H ₄ CONHR (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ CONHR (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ COO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ O-, _{-OC 6 H 4 CONH (CR 3} R 4) γ O (CR 5 R 6) τ -, -OC 6 H 4 CONH (CR 3 R 4) γ NHCO-, -OC 6 H 4 CONH (CR 3 R 4 ) _γ NHCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ Aliphatic or aromatic derivatives selected from the group consisting of; Γ and τ are each carbon repeating unit including R ₃ and R ₄ and R ₅ and R ₆ irrespective of each other and have a value of 1 to 20 carbon atoms and R ₃ , R ₄ , R ₅ and R ₆ are A method for producing a self-assembling brush polymer compound, which is an alkyl group having 1 to 20 carbon atoms regardless of each other. 7. The method of claim 6, wherein Z is formed by an ester condensation reaction. 7. The method of claim 6, wherein the terminal of L1 is -OH and the terminal of L2 is -COOH. 7. The method of claim 6, wherein the formula (4) is 6- (9-adenyl) ethyloxycarbonylethylcarbosonic acid. 10. The method of claim 9, wherein the 6- (9-adenyl) ethyloxycarbonylethylcarbosonic acid silver is prepared by reacting 9- (2-hydroxyethyl) denine with succinyl anhydride. Method for producing self-assembling brush polymer compound. A biomaterial made of a biocompatible self-assembling brush polymer compound represented by Formula 1 below.

(One) Where ρ and σ represent repeating units of carbon comprising R ₁ and R ₂ and are values of 1 to 20 regardless of each other; R ₁ and R ₂ are each independently hydrogen, an alkyl group having 1 to 20 carbon atoms;   m and n represent the content (mol%) of the polyether unit, where 0 <m ≦ 100, 0 ≦ n <100, and m + n = 100;  Y is H, an alkyl group having 1 to 20 carbon atoms, or a ring containing E, G, J, L, M, Q, T, U, V, W, α, β, and γ at the -Z end; Z is -CH ₂ S (CR ₃ R ₄ ) _γ O-, -CH ₂ S (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -CH ₂ S (CR ₃ R ₄ ) _γ OCO- , -CH ₂ S (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ S (CR ₃ R ₄ ) _γ COO-, -CH ₂ S (CR ₃ R ₄ ) _γ COO (CR _{5 R 6) τ -, -CH} 2 S (CR 3 R 4) γ NHCO-, -CH 2 S (CR 3 R 4) γ NHCOO (CR 5 R 6) τ -, -CH 2 S (CR 3 R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ S (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ S (CR ₃ R ₄ ) _γ CO-, -CH ₂ S (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ O-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ OCO-, -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO _{(CR 3 R 4) γ COO-} , -CH 2 SO (CR 3 R 4) γ COO (CR 5 R 6) τ -, -CH 2 SO (CR 3 R 4) γ NHCO-, -CH 2 SO ( CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ SO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO (CR ₃ R ₄ ) _γ CO-, -CH ₂ SO (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ -,- _{CH 2 SO 2 (CR 3 R} 4) γ COO-, -CH 2 SO 2 (CR 3 R 4) γ COO (CR 5 R 6) τ -, -CH 2 SO 2 (CR 3 R 4) γ NHCO- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -CH ₂ SO ₂ ( CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ CO-, -CH ₂ SO ₂ (CR ₃ R ₄ ) _γ CO _{(CR 5 R 6) τ -} , -OCO (CR 3 R 4) γ O-, -OCO (CR 3 R 4) γ O (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ OCO _{-, -OCO (CR 3 R 4} ) γ OCO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ COO-, -OCO (CR 3 R 4) γ COO (CR 5 R 6) τ _{-, -OCO (CR 3 R 4} ) γ NHCO-, -OCO (CR 3 R 4) γ NHCO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ OCO (CH 2) 2 OCO- _{, -OCO (CR 3 R 4)} γ OCO (CH 2) 2 OCO (CR 5 R 6) τ -, -OCO (CR 3 R 4) γ CO-, -OCO (CR 3 R 4) γ CO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ O-, -COO (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ OCO-, -COO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ COO-, -COO (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ NHCO-, -COO (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ -,- COO (CR ₃ R ₄ ) _γ CO-, -COO (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ O-, -O (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _γ OCO-, -O (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -O (CR ₃ R ₄ ) _{γ COO-, -O (CR 3 R} 4) γ COO (CR 5 R 6) τ -, -O (CR 3 R 4) γ NHCO-, -O (CR 3 R 4) γ NHCO (CR 5 R 6 ) _τ- , -O (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -O (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -O ( CR ₃ R ₄ ) _γ CO-, -O (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ O-, -NH (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ OCO-, -NH (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ COO _{-, -NH (CR 3 R 4} ) γ COO (CR 5 R 6) τ -, -NH (CR 3 R 4) γ NHCO-, -NH (CR 3 R 4) γ NHCO (CR 5 R 6) τ -, -NH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -NH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -NH (CR ₃ R ₄ ) _γ CO-, -NH (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ O-,-(CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ OCO-,-(CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ -,-(CR ₃ R ₄ ) _γ (CH ₂ ) _n COO-,- _{(CR 3 R 4) γ (} CH 2) n COO (CR 5 R 6) τ -, - (CR 3 R 4) γ NHCO-, - (CR 3 R 4) γ NHCO (CR 5 R 6) τ - ,-(CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-,-(CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ O-, -OC ₆ H ₄ (CR ₃ R ₄ ) _γ O (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ ( _{CR 3 R 4) γ OCO-,} -OC 6 H 4 (CR 3 R 4) γ COO (CR 5 R 6) τ -, -OC 6 H 4 (CR 3 R 4) γ NHCO-, -OC 6 H _{4 (CR 3 R 4) γ} NHCO (CR 5 R 6) τ -, -OC 6 H 4 (CR 3 R 4) γ -, -OCO (CH 2) 2 OCO-, -OCO (CH 2) 2 OCO (CR ₃ R ₄ ) _γ- , -OC ₆ H ₄ (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ COO- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ O-, -OC ₆ H ₄ COO (CR ₃ R _{4) γ O (CR 5 R} 6) τ -, -OC 6 H 4 COO (CR 3 R 4) γ NHCO-, -OC 6 H 4 COO (CR ₃ R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ COO (CR ₃ R ₄ ) _γ CO ( CR ₅ R ₆ ) _τ -or -OC ₆ H ₄ CONHR (CR ₃ R ₄ ) _γ OCO-, -OC ₆ H ₄ CONHR (CR ₃ R ₄ ) _γ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ COO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ COO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ O _{-, -OC 6 H 4 CONH (} CR 3 R 4) γ O (CR 5 R 6) τ -, -OC 6 H 4 CONH (CR 3 R 4) γ NHCO-, -OC 6 H 4 CONH (CR 3 R ₄ ) _γ NHCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ OCO (CH ₂ ) ₂ OCO (CR ₅ R ₆ ) _τ- , -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ CO-, -OC ₆ H ₄ CONH (CR ₃ R ₄ ) _γ CO (CR ₅ R ₆ ) _τ -an aliphatic or aromatic derivative selected from the group consisting of; Γ and τ are each carbon repeating unit including R ₃ and R ₄ and R ₅ and R ₆ irrespective of each other and have a value of 1 to 20 carbon atoms and R ₃ , R ₄ , R ₅ and R ₆ are Irrespective of one another, hydrogen, an alkyl group having 1 to 20 carbon atoms; E, G, J, L, M, Q and T are selected from the group consisting of C, N, O, P or S; U, V, W, α, β and γ are -CHO, -COOH, -COOR, -C = NR, -H, -N ₃ , -NO ₂ , -N = R, -NH ₂ , -NHR, -NR ₂ , -NR ₃ ⁺ , -OH, -OCR, -OR, -POH, -P0R, -PO ₂ H, -PO ₂ R, -PO ₃ H, -PO ₃ R , -SH, -SR, -SOH, -SOR, -S0 ₂ H, -S0 ₂ R, -SO ₃ H, SO ₃ R, = O, = N, = S and -C ₆ H ₅ from the group consisting of Selected; The weight average molecular weight of the mercury ion detection function brush polymer compound is 5,000 to 5,000,000. 12. The biomaterial according to claim 11, wherein the biomaterial has an ability to improve adhesion, adsorption, or adhesion to cells. The biomaterial of claim 12, wherein the cells are HEp-2 cells. The biomaterial according to claim 11, wherein the biomaterial has an ability to inhibit adhesion, adsorption, or adhesion to pathogenic bacteria. The biomaterial of claim 14, wherein the pathogenic bacterium is P.aeruginosa, S.aureus, S. epidermidis, E. faecalis, or E.coli . A biocompatible member produced by processing the biomaterial according to claim 11. Protein adsorption member comprising a thin film using the polymer compound according to claim 1. Protein analysis member comprising a thin film using the polymer compound according to claim 1. A material according to claim 1, wherein the polymeric compound is coated such that the terminal functional groups are oriented in a layered manner over a large area perpendicular to the surface. A self-assembling brush polymer compound characterized in that a cyclic compound of formula (6) is bonded through T to at least a part of the brush end of the polyether brush polymer;

(6) Wherein E, G, J, L, M, Q and T are selected from the group consisting of C, N, O, P or S; U, V, W, α, β, and γ are -CHO, -COOH, -COOR, -C = NR, -H, -N ₃ , -NO ₂ , -N = R, -NH ₂ , -NHR, -NR ₂ , -NR ₃ ⁺ , -OH, -OCR, -OR, -POH, -P0R, -PO ₂ H, -PO ₂ R, -PO ₃ H, -PO ₃ R , -SH, -SR, -SOH, -SOR, -S0 ₂ H, -S0 ₂ R, -SO ₃ H, SO ₃ R, = O, = N, = S and -C ₆ H ₅ from the group consisting of Is selected.

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