KR20100041357A - Toothpaste composition - Google Patents

Abstract

PURPOSE: A toothpaste composition containing calcium carbonate, sodium hydrogen carbonate, and sodium carbonate is provided to ensure adjusted alkaline property by pH 9-10 and prevent dental caries. CONSTITUTION: A toothpaste composition contains 0.01-10 weight% of calcium carbonate, 0.01-20 weight% of sodium hydrogen carbonate, and 5-50 weight% of sodium carbonate. The toothpaste composition has pH 9-10 concentration. The composition further contains 1-50 weight% of humectants of concentrate glycerin, glycerin, sorbitol solution, non-crystal sorbitol solution, polyethyleneglycol or propyleneglycol. The composition also contains 0.1-5 weight% of binder of carboxymethylcellulose sodium, carbomer, carrageenan, xanthangum, or alginates.

Description

Toothpaste composition

The present invention relates to a toothpaste composition containing calcium carbonate, sodium bicarbonate and sodium carbonate, and more particularly, to the pH of the toothpaste composition containing calcium carbonate and sodium bicarbonate using sodium carbonate, preferably to pH 9-10 By adjusting the buffer action by the common ion effect of sodium bicarbonate and sodium carbonate to provide a toothpaste composition to quickly neutralize the acidified oral cavity to prevent dental caries.

Dental caries is Streptococcus mutans of the 200 species of microorganisms to survive in the mouth; that plaque on the tooth surface such as a water-insoluble glucan and microorganisms in food and residues including (Streptococcus mutans S. mutans) oral disease causing bacteria that produce tangled with each other It is a disease caused by demineralization of the inorganic components of the enamel layer of the tooth by forming a dental plaque and lowering the pH in the oral cavity to 5.5 or less by various organic acids which are metabolites of these microorganisms.

After drinking or eating a soft drink, the mouth changes to an acidity below the demineralization threshold pH of the tooth enamel, so that if the drink is ingested frequently or the teeth are not washed after a meal, demineralization of the tooth surface is greatly increased. Therefore, the time to return to normal oral pH (6.8 ~ 7.2) after intake of soft drink or meal is very important.

Meanwhile, Dawes, C. recently published a study showing that toothpaste containing sodium bicarbonate neutralized acid by Plague (1997). However, testing with a toothpaste containing sodium bicarbonate to return to normal pH of the oral cavity, it takes a long time to neutralize the pH in the oral cavity, which is thought to prevent more effective prevention of dental caries.

Increasing oral pH neutralization was thought to increase dental caries prevention. Therefore, research on oral pH buffering is needed.

The present invention was confirmed that the addition of sodium carbonate in the toothpaste composition containing calcium carbonate and sodium bicarbonate during the oral pH buffering experiment to recover the pH dropped by the first carbonated beverage to quickly increase the neutralization of the pH and complete the present invention. Was done.

The present invention relates to a toothpaste composition containing calcium carbonate, sodium bicarbonate and sodium carbonate, and more particularly, to the pH of the toothpaste composition containing calcium carbonate and sodium bicarbonate using sodium carbonate, preferably to pH 9-10 By adjusting the buffer action by the common ion effect of sodium bicarbonate and sodium carbonate to provide a toothpaste composition to quickly neutralize the acidified oral cavity to prevent dental caries.

The present inventors studied the oral neutralization by calcium carbonate and sodium bicarbonate, and adjusted the pH of the toothpaste composition containing calcium bicarbonate and sodium bicarbonate using sodium carbonate, preferably by adjusting the pH to 9-10, and hydrogen bicarbonate. Due to the buffer action by the common ion effect of sodium and sodium carbonate, it was found to be more effective in dental caries by neutralizing acidified oral cavity rapidly. Calcium carbonate is generally used as an abrasive, but has a higher pH than silica.

Sodium carbonate used in the toothpaste composition of the present invention is used as an amount of 0.01% to 10% by weight of the total weight of the composition, the effect is less than these concentration ranges, and the cost is higher than the factor of effect increase above, but also toothpaste There are problems such as unstable stability.

Sodium hydrogen carbonate used in the toothpaste composition of the present invention is used as an amount of 0.01% to 20% by weight of the total weight of the composition, the effect is less than these concentration range and there is a problem in stability such as pH instability above.

Calcium carbonate used in the toothpaste composition of the present invention is used as an amount of 5% to 50% by weight of the total weight of the composition, the effect is less than these concentration ranges, and difficult to form the toothpaste and the cost is higher than that There is a problem.

Typical components required to prepare the dentifrice composition include wetting agents, abrasives, agonists, sweeteners, pH adjusters, preservatives, binders, flavoring agents, foaming agents and the like.

The humectant is used alone or in combination of a group consisting of concentrated glycerin, glycerin, sorbitol aqueous solution, amorphous sorbitol aqueous solution, polyethylene glycols, and propylene glycol, the amount of which is contained in an amount of 1 to 50% by weight based on the total weight of the toothpaste composition.

The abrasive is selected from the group consisting of precipitated silica, silica gel, zirconium silicate, calcium dihydrogen phosphate, calcium monohydrogen phosphate, hydrous alumina, hard calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate and aluminum silicate. Etc. can be used. In addition, additives used in small amounts include sweeteners, pH adjusters, preservatives, colorants, and binders as components commonly used in toothpaste.

The medicament may be one or more fluorine compounds selected from sodium phosphate, sodium fluoride, amine fluoride and tin fluoride, sodium pyrophosphate, potassium pyrophosphate or acidic pyrophosphate, enzymes, aminocaproic acid, allantoin or allantoin derivatives or One or more vitamins can be used selectively.

As sweeteners, saccharin sodium, xylitol, erythritol, saccharin sodium, aspartame, etc. may be used, and as the pH adjusting agent, sodium phosphate, disodium phosphate, citric acid, triethanolamine, etc. may be used. Sodium and the like can be used.

As the binder, carboxymethyl cellulose sodium, carbomer, carrageenan, xanthan gum, alginate and the like can be used. The amount of the binder is used in an amount of 0.1 to 5% by weight based on the total weight of the toothpaste composition.

As a fragrance, peppermint duck, spearmint oil, menthol, etc. may be mixed and used, and other additives, such as texaranase, may also be used.

As the foaming agent, sodium lauryl sulfate as an anionic surfactant, a copolymer of polyoxyethylene polyoxypropylene as a nonionic surfactant (poloxamer), polyoxyethylene hardened castor oil, polyoxyethylene sorbitan fatty acid ester and the like can be used. .

In addition, it contains a residual amount of water.

The present invention relates to a toothpaste composition containing calcium carbonate and sodium hydrogen carbonate. More particularly, the pH of the toothpaste composition containing calcium carbonate and sodium hydrogen carbonate is preferably added by adding sodium carbonate and a pH adjuster. By adjusting it to 9 ~ 10, the buffering action by the common ion effect of sodium bicarbonate and sodium carbonate rapidly neutralized the acidified oral cavity, thereby obtaining an excellent effect of preventing dental caries.

Hereinafter, the present invention will be described in detail with reference to Examples. However, embodiments according to the present invention can be modified in many different forms, the scope of the invention should not be construed as limited to the embodiments described below. The embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

Examples 1 to 2 and 1 to 6 in comparison

Toothpaste compositions according to the present invention (Examples 1 to 2) and conventional toothpaste compositions (Comparative Examples 1 to 6) for comparison with the composition ratio as shown in Table 1 below were prepared.

The manufacturing method is as follows. : Disperse powder components such as xanthan gum, saccharin, and preservative in wet crystalline amorphous sorbitol solution, dilute with purified water, and then mix in a mixer first, and then add abrasives such as precipitated silica and medicinal agents, and mix Finally, a foaming agent was added sodium lauryl sulfate, stabilizers, flavoring ingredients and mixed in a vacuum to prepare a toothpaste composition.

Unit weight% Name Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Calcium carbonate 20.0 20.0 20.0 20.0 20.0 20.0 20.0 20.0 Sodium carbonate 0.01 10 - - - - 0.01 10 Sodium bicarbonate 10 10 10 10 - - 10 10 Concentrated glycerin 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 Sorbitol solution 30.0 30.0 30.0 30.0 30.0 30.0 30.0 30.0 Sodium Lauryl Sulfate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Carboxymethyl Cellulose Sodium 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Xanthan Gum 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Sodium fluoride 0.22 0.22 0.22 0.22 0.22 0.22 0.22 0.22 Spices 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Saccharin 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Citric Acid, Triethanol amine (TEA) Quantity Quantity Quantity Quantity Quantity Quantity Quantity Quantity Purified water To100 To100 To100 To100 To100 To100 To100 To100 pH pH9.0 pH10.0 pH9.0 pH10.0 pH9.0 pH10.0 pH7.0 pH11.0

(The pH was adjusted using citric acid, TEA, etc.)

In the present invention, the following experiments were performed to compare oral plaque pH changes and gingivitis.

Experimental Example 1 Measurement of Changes in Intraoral Plaque pH

1) Subject

Among 30 patients aged 30 to 40 years, the oral examination was performed and 20 subjects were selected as study subjects who had no dental caries and had a pH of less than 5.0 with 10% glucose solution. The irritant saliva secretion measured by subjects chewing paraffin wax for 5 minutes was 1.31 ml / min.

2) the manufacture of intraoral devices

After the upper and lower jaw impressions were taken from the subjects, the oral model was made by pouring plaster, and then the intraoral maintenance device was manufactured using the acrylic resin and the 0.7mm wire for the mandibular second premolar and the second molar. Try to mount the device for one day and check if there is any inconvenience. If there is no inconvenience, make a window where artificial Hydroyxapatite (HA, app-100, Pentax, Japan) will be located and make a space for the microelectrode to enter. It was. The microelectrode (MEBH-1, Beetrode, WP instruments, USA) used in this experiment used a product with a tip diameter of 100um and a length of 5mm, which was connected to a pH meter (ORIONSA, U.S.A). After artificial hydroxyapatite (HA) was made into 3x3 mm, windows artificial HA formed in the device was placed and the margin was treated with acrylic resin to prevent separation from the device. The end of the microelectrode was placed on the artificial HA site, and the microelectrode wire was placed in the formed groove and covered with acrylic resin and buried. The finished device was kept in water for one day to allow all harmful resin components to elute.

3) Experiment Method

In order to deposit plaque on the microelectrode, the completed device was mounted on the subject for 3 days. At this time, the device was to be removed in the oral cavity only when the food intake or brushing, the rest of the time was to be installed. When the plaque was found to cover the entire surface of the microelectrode thinly, the experiment was started. The subject was seated in a chair, connected to a pH meter and a computer reading the measured value, and then gargled with a 50 ml carbonated beverage using a pipette, and diluted 1 to 6 compositions in comparison with Examples 1 to 2 of Table 1 above. A 1 ml was sprayed on the microelectrode tip of the oral device and the pH change was observed for 30 minutes. After 30 minutes, paraffin wax was chewed to return to normal oral pH of the subject. When the subject was originally restored to the oral pH, the above method was repeated.

In comparison with Examples 1 to 2 of Table 1, the change in plaque pH of the composition 1 to 6 was continuously measured at a price of 10 minutes, and the degree of pH change over time was measured. (p <0.05)

Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Early 6.45 ± 0.21 6.26 ± 0.19 6.33 ± 0.27 6.56 ± 0.02 6.23 ± 0.26 6.51 ± 0.31 6.52 ± 0.24 6.29 ± 0.14 10 minutes 6.06 ± 0.22 5.87 ± 0.20 5.45 ± 0.08 5.42 ± 0.21 5.45 ± 0.05 5.24 ± 0.22 5.33 ± 0.18 5.52 ± 0.27 20 minutes 6.34 ± 0.31 6.21 ± 0.23 5.59 ± 0.27 5.51 ± 0.26 5.52 ± 0.14 5.35 ± 0.21 5.42 ± 0.24 5.65 ± 0.10 30 minutes 6.40 ± 0.13 6.31 ± 0.18 5.61 ± 0.32 5.72 ± 0.31 5.76 ± 0.09 5.43 ± 0.10 5.65 ± 0.45 5.48 ± 0.25

Comparing Examples 1 to 2 and Comparative Examples 1 and 6, Examples 1 to 2 recovered similarly to the initial pH after about 30 minutes, but Comparative Examples 1 to 6 did not completely recover to the initial pH. It is considered that Comparative Examples 1 to 6 are more likely to suffer dental caries than Examples 1 to 2.

Claims (5)

A toothpaste composition comprising calcium carbonate, sodium bicarbonate and sodium carbonate. According to claim 1, Toothpaste composition characterized in that it contains 0.01% to 10% by weight of sodium carbonate, 0.01% to 20% by weight of sodium bicarbonate, 5% to 50% by weight of calcium carbonate The toothpaste composition of Claim 1 or 2 whose pH is 9-10. The method according to claim 1 or 2, further comprising one or more wetting agents selected from concentrated glycerin, glycerin, sorbitol aqueous solution, amorphous sorbitol aqueous solution, polyethylene glycols and propylene glycol, wherein the wetting agent is based on the total weight of the toothpaste composition Toothpaste composition, characterized in that containing 1 to 50% by weight. According to claim 1 or 2, Carboxymethyl cellulose sodium, carbomer, carrageenan, xanthan gum and alginate further comprises one or more binders, 0.1 to 5% by weight relative to the total weight of the toothpaste composition Toothpaste composition which makes things contain%.