KR20090028086A - System and method for injecting liquid material into living body - Google Patents

Abstract

A device and a method for injecting liquid material are provided, which prevent the damage of tissue after causing change of living body tissue according to amount or the volume of the liquid materials injected within the living body. A device for injecting liquid material comprises: an injection member(100) for supplying the liquid materials to the living body; a volume measurement unit(120) measuring the volume change of the liquid materials supplied through the injection member; a pressure change measurement unit(140) measuring the change of the increased pressure in the specific tissue of the living body due to the liquid materials supplied within the living body; and a display(180) visualizing the volume comparison pressure change using the signal related to the pressure and volume change.

Description

FIELD OF THE INVENTION [0001] The present invention relates to an apparatus for injecting a liquid substance into an organism,

The present invention relates to a device for injecting a liquid material into an organism and a method for injecting a liquid material, and it proposes an apparatus and a method for controlling the injection of a liquid material according to a change in volume versus pressure by monitoring the volume and change of the injected liquid material in real time .

It is common to inject liquid substances such as liquids or drugs into the human body or animal or plant to perform medical treatment or biological treatment.

The amount (or volume) of the liquid substance as well as the constituents of the liquid substance injected in such medical treatment and biological treatment are important parameters in relation to the state of the organism tissue.

An example of performing medical treatment through injection of a liquid material is treatment for adhesive capsulitis. Adhesive ischemic colitis, also referred to as a frozen shoulder, is a condition in which pain and severe shoulder movement limitation occur in the shoulder area. It is a method to alleviate the adhesions in the attached shoulder capsule, Has not yet been revealed.

As another alternative treatment for adhesiolysis of the shoulder, hydronephrosis of the capsular bag, which injects a sufficient amount of physiological saline into the shoulder, has been performed. This is because there is no systematic study of how much fluid should be injected during the swelling of the capsular capsulitis, and the clinical effect of the swelling is different from the amount of fluid injected. In addition, if the capsule is ruptured during hydraulic expansion, the joint may become unstable during shoulder movement, and there is a possibility of more severe adhesion after rupture.

In addition, researches and methods have not yet been developed to obtain optimal effects while preventing the destruction of the internal tissues of the living body when liquid substances are injected into the human body or animals and plants and animals.

It is an object of the present invention to provide a method for producing a biocompatible microorganism which causes a plasticity change in an organism tissue in accordance with the amount and volume of a liquid substance into which liquid substances such as liquids and drugs injected into an organism are injected for the purpose of medical treatment or biological treatment, To prevent destruction.

Another object of the present invention is to improve stability and efficacy of injecting a liquid material for the recovery of injured tissue in the human body such as adhesions and treatment of seminal vesicle.

Other objects and features of the present invention will be described in detail below with reference to preferred embodiments.

In order to attain the above object, the present invention provides an apparatus for measuring a liquid substance, comprising: injection means for supplying a liquid substance into an organism; volume measuring unit for measuring a volume change of the liquid substance supplied through the injection means; A pressure change measurement unit for measuring a change in pressure that is increased in a specific tissue within the organism, and a display for visualizing volume change versus volume using a signal related to volume change and pressure change delivered from the two measurement units A liquid substance injecting device for injecting a liquid substance into the living body.

The display preferably visualizes at least a linear change interval of the pressure change versus the volume and a drop interval of the pressure change relative to the volume. To this end, the apparatus according to the present invention may further include a separate software for visualizing the pressure change mode, and may further include a control unit for controlling the injection of the liquid material from the pressure change, if necessary.

It is preferable to control to stop the injection of the liquid material when the change in the volume-to-volume pressure reaches a certain point, and a separate control unit may be provided for this purpose.

The present invention also relates to a method for measuring a change in pressure of a living organism, comprising: injection means for feeding a liquid material into an organism; a pressure change measurement unit for measuring a change in pressure that is increased in a specific tissue inside the organism due to the liquid material supplied into the organism; And a display for visualizing a pressure change with respect to an injection time of the liquid material using a signal related to a pressure change transmitted from the liquid material injection device.

The present invention also provides a method for injecting a liquid substance into a body of an animal or a plant other than a human, comprising the steps of measuring the volume of a liquid substance injected into a body of an animal or a plant, The volume of the liquid material to be injected is measured in real time by monitoring the correlation of the pressure in the body with the volume of the injected liquid material to calculate the volume-to-volume pressure change, And the injection of the liquid material is stopped when the liquid material is observed.

A first step of measuring a linear change period of the pressure change relative to the volume in the calculation of the change in volume versus pressure, and a second step of measuring a change in the plasticity of the body tissue by the liquid material injected after the linear change period And a second step of performing the second step.

The present invention also provides a method of injecting a liquid substance into the body of an animal or a plant other than a human, comprising the steps of measuring the pressure in the body caused by a liquid substance injected into the body of an animal or a plant, And the pressure is monitored in real time to calculate the pressure change with time, and when the decrease in the pressure change with time is observed, the injection of the liquid material is stopped.

According to the present invention, the correlation between the change in the volume of the injected liquid material and the change in the pressure due to the liquid material is monitored in real time. When the attenuation region of the pressure change relative to the volume is observed, injection of the liquid material is stopped, It can improve the stability and effectiveness of enemas or biological treatment.

The present invention relates to a method for observing the physical change of an organism tissue in real time according to the amount and volume of a liquid substance such as liquid or drug injected into an organism for medical treatment or biological treatment, It is characterized in that the mode is analyzed and the result is analyzed graphically to properly control the injection of the liquid material before the tissue is destroyed by the excessively injected liquid material.

To this end, the apparatus for injecting a liquid material according to an embodiment of the present invention may include, for example, as shown schematically in FIG. 1, a liquid volume injecting means 100, a volume measuring unit 120 and a pressure measuring unit 140 ). The volume measuring unit 120 measures the volume of the liquid material injected into the organism in real time to generate an electrical signal or to generate digitized data. The volume measuring unit 140 measures the change (increase) of pressure in (specific) tissues in an organism according to the change (increase) in the volume of the liquid material injected into the organism to generate an electrical signal or digitize Lt; / RTI >

The liquid material injecting apparatus of the present invention also includes a display 180 that visualizes the volume change versus volume using signals related to volume and pressure changes delivered from the volume measurement unit and the pressure measurement unit. The display may be a general computer monitor, a laptop computer, or the like, or may be a separately designed dedicated monitor. In addition, the display preferably graphically displays at least a linear change interval of pressure change versus volume and a decrease interval of pressure change versus volume (or a decay interval of change rate).

The present invention may further include a data processing unit 160 that converts the signals transmitted from the volume measuring unit and the pressure measuring unit into electronic data that can be processed by a computer or the like. Alternatively, the data processing unit may be integrally integrated with the display Alternatively, the volume measuring unit and / or the pressure measuring unit and the data processing unit may be integrally integrated.

In one embodiment of the present invention, the injection means 100 may include a container or a reservoir 210 containing a liquid material, for example, as shown in FIG. 2, A hose 220 for guiding the movement of the material, and a leading needle 230 connected to the hose end part and permeating into the organism. The reservoir may be formed in the form of a syringe, and further includes an infusion pump (not shown) for controlling the amount of infusion of the liquid material and the infusion interval at the rear end of the reservoir (or formed integrally with the reservoir) .

Such an injection pump may have a function of controlling the injection of the liquid material to be automatically stopped when the pressure change relative to volume reaches a specific point or region upon injection of the liquid material. For example, when the liquid material is injected using the injection pump, the liquid material may be continuously injected with respect to time, but in some cases, it may be controlled to be discontinuously injected at predetermined time intervals.

In the present invention, the volume measuring unit may have an independent sensor for directly measuring the volume of the liquid material to be injected, but the volume of the liquid material may be indirectly calculated through the volume change of the reservoir. For example, by measuring the internal cross-sectional area of a syringe-type reservoir and the rate at which the rear end of the syringe moves (according to the injection of the liquid in the syringe), the volume of the injected liquid material can be quantitatively calculated over time. On the other hand, the pressure measuring unit of the present invention may be provided with an independent pressure measuring sensor or may indirectly measure the pressure by providing a means for measuring a change in pressure or the like in the vicinity of the tissue into which the liquid material is injected. For example, a pressure sensor may be connected to a portion of the hose 220 of the injection means 100 and a pressure sensor may be positioned between the reservoir 210 and the hose 220 or between the hose and the leading needle 230 It is possible. In the present invention, there is no need to limit the means and method for volumetric measurement and pressure measurement.

In another embodiment of the present invention, the injection of the liquid material can be controlled by monitoring the pressure change with time of the injection of the liquid material without including the volumetric unit. In this case, the apparatus for injecting a liquid material according to the present invention comprises injecting means for injecting a liquid substance into an organism, pressure means for measuring a pressure change in a specific tissue inside the organism due to the liquid substance supplied into the organism, And may only include a display that visualizes the pressure change with respect to the injection time of the liquid material using the signal associated with the pressure change delivered from the measurement unit.

FIG. 3 is an exemplary flowchart showing a liquid material injection, a volume and pressure change monitoring, and a liquid material injection control process according to a preferred embodiment of the present invention.

Liquid substances such as liquids and medicines are injected into specific tissues (joints, subcutaneous tissues, blood vessels, etc., such as shoulders, knees, waist, ankles, etc.) in the human body (step S1). In addition to the injection of the liquid material, the volume at which the liquid material is injected in real time and the pressure change of the injected liquid material are measured (step S2).

In order to precisely measure the pressure and / or volume to be described later, the liquid material may be injected at a constant rate (flow rate) with respect to time, Can be measured.

(Or the rate of change) of the volume or pressure from the measured value for the pressure change and / or the volume change or from the signal transmitted from the measurement sensor (step S3). This step of calculating the volume-to-volume change may further include monitoring the volume of the liquid material to be injected and the pressure thus increased to convert the volume and pressure information into data graphically or tabularly displayed on the display . The data conversion may be performed by a program pre-installed in a computer or the like.

In another embodiment of the present invention, instead of calculating the change in volume versus pressure, only a change in pressure (or rate of change) over time may be calculated.

In step S6, the control unit 20 monitors the correlation of the pressure in the human body with the volume of the injected liquid material in real time to calculate the pressure-to-volume change.

A first step (S4) of determining a linear change period of pressure change versus volume in the calculation of the change in volume versus pressure, and a second step (S4) of determining a change in volume of the body tissue by the liquid material injected after the linear change period. And a second step (step S5) of confirming a region where the change is observed. In this case, it is preferable to stop the injection of the liquid material in the region where the plasticity change is observed.

It is preferable that the control of the injection of the liquid material is controlled by analyzing the change in the volume-to-volume pressure (or the pressure change with time) visually through a graph or a table in real time.

FIG. 4 is a graph showing a pressure change relationship according to a volume change of a liquid material injected when a liquid material is injected into a human body using a liquid material injecting apparatus according to the present invention.

According to the injection of the liquid material, the pressure does not change or gradually changes until a point. Up to this point, it is defined as the first phase section (I), and the pressure change from the point a to the point b is abrupt and the linear volume- (II), and the interval from the point (b) to the point (c) where the change in pressure gradually decreases and the plastic changes are defined as the third phase section (III) have. After point c, the pressure is no longer increased by injection of the liquid material and the tissue is destroyed after point d.

In the graph of FIG. 4, point d, which is the time point at which the tissue is broken, is a time point to be avoided in medical treatment or biological treatment by injecting a liquid material. Therefore, when reaching the third phase region, It is important to stop the material injection. The third phase section is expressed after the second phase section, and the second phase section is a time at which the increase of the stress linearly (one-dimensional function) occurs as the volume increases after the first phase section. The time point at which the third phase section becomes the second phase section is a point where the linear relationship is broken and a curve showing a decrease in the pressure change caused by the same volume change is shown.

In the present invention, the linear change section does not necessarily have to be a 'geometric straight line'. Preferably, if the change rate of the pressure to the volume (dP / dV) is included in the numerical range defined by the predetermined range, Can be regarded as' The reason for imparting fluidity to such a linear change section is that, for example, when a liquid material is injected due to a large number of change factors in a living body's body, it is considered that the change of the pressure is not completely 'linearly changed' .

It will be appreciated by those skilled in the art, that those skilled in the art of the present invention will understand that the shape of the linear change interval (for example, the volume versus pressure change slope or change rate) may vary depending on the sex, age, health condition, You can do it.

Example

The injection of the liquid material and the injection method according to the present invention were applied to the hydraulic expansion to expand the attached shoulder capsule, and the change in the volume of the capsule and the pressure at the time of injection of the fluid was measured, The duration of fluid infusion was controlled by checking the change interval and the plasticity change interval.

Specifically, pressure in the joints was measured in real time during hydrostatic expansion of shoulder capsuli in patients with frozen shoulder. First, a 50 ml syringe connected with a needle for spinal intervention was used as a fluid infusion means, and a fluid was injected into the syringe. The sap used was mixed with 0.9% normal saline and 1% lidocain in a ratio of 2: 1 and 1 ml of triamcinolone 40 mg was added. The needle was inserted into the patient's shoulder joint and the fluid was injected into the joint.

1 ml of liquid was injected through the liquid injecting means, and the liquid was injected again after waiting for 5 seconds. The pressure was continuously measured while the infusion was stopped. The pressure was monitored to see if a third phase interval was present, and infusion (1 mL) and pause (5 seconds) were repeated. The maximum infusion volume was limited to 40 ml.

Measurements of volume changes and intra-articular pressure due to infusion of fluid were transferred to a computer in real time and visualized in graphs. The fluid was injected by observing the change in pressure. When the third phase was observed and the point at which the volume-pressure curve appeared flat was stopped, the infusion of the fluid was stopped.

FIG. 5 shows a graph of the volume-pressure change measured according to the infusion of fluid into the dogs of the dogs. The linear change interval and the change point of the plasticity can be clearly seen. FIG. 6 shows a graph of the volume-pressure change of a number of patients with osteoporosis, and it was confirmed that the shape of the volume-pressure change was somewhat different depending on the patient, but the linear change interval and the plasticity change point occurred in most cases. Using this graph of volume-pressure change, the stability and efficacy of treating osteoporosis can be further improved. In particular, the optimal pressure and volume at which the third phase appears when hydrodynamic expansion is performed for the treatment of osteoporosis.

Meanwhile, it is confirmed that the present invention can obtain similar results as in the previous embodiment by monitoring the correlation of the pressure change over time during the liquid material injection process in real time. FIG. 7 is a graph showing a change in pressure while infusing fluid into a patient with a frozen shoulder. It can be clearly seen that a linear section and a change point of the plasticity change with time are generated similarly to the graph of FIG.

The present invention can be effectively applied not only to the treatment of joints, muscles and other tissues within the human body but also to medical treatment and physiological treatment of animals or plants other than humans.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, Modified, modified, or improved.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic diagram showing a configuration of a liquid material injection apparatus according to an embodiment of the present invention; FIG.

2 is a schematic view showing an example of an injection means of the present invention.

3 is a flowchart showing a method of injecting a liquid material according to an embodiment of the present invention.

FIG. 4 is a graph showing the volume-pressure change measured through injection of a liquid material according to the present invention. FIG.

FIG. 5 is a graph showing the measured volume-pressure changes for a frozen shoulder patient according to an embodiment of the present invention. FIG.

Figure 6 is a graph showing the measured volume-to-pressure variation for a fellow dog according to another embodiment of the present invention.

FIG. 7 is a graph showing time-pressure changes measured for a fellow dog according to another embodiment of the present invention. FIG.

DESCRIPTION OF THE REFERENCE SYMBOLS

100: liquid material injecting means 120: volume measuring unit

140: Pressure measuring unit 160: Data processing unit

180: Display

Claims (14)

An injection means for supplying a liquid material into the organism, A volume measuring unit for measuring a volume change of the liquid material supplied through the injecting unit, A pressure change measurement unit for measuring a change in pressure that is increased in a specific tissue inside the organism due to the liquid substance supplied into the organism; And a display for visualizing the volume change versus volume using a signal related to volume change and pressure change delivered from the two measurement units An apparatus for injecting a liquid substance into an organism. 2. The apparatus of claim 1, wherein the display visually depicts at least a linear change interval of pressure change versus volume and a decrease interval of pressure change relative to volume. The method of claim 1, wherein the injection means comprises a reservoir containing liquid material, a hose for guiding movement of the liquid material from the reservoir to a corresponding portion of the organism, An apparatus for injecting a liquid substance into an organism including a needle tip. 2. The apparatus according to claim 1, further comprising an injection pump for controlling an injection amount and an injection interval of the liquid material supplied into the organism through the injection means. 5. The apparatus according to claim 4, wherein the injection pump controls to stop the injection of the liquid material when the change in the volume-to-volume pressure reaches a certain point. 5. The apparatus according to claim 4, wherein the injection pump controls the liquid material to be discontinuously injected at predetermined time intervals. The apparatus according to claim 1, further comprising a data processing unit for converting a signal transmitted from the volume measuring unit and the pressure measuring unit into electronic data that can be calculated by a computer or the like. An injection means for supplying a liquid material into the organism, A pressure change measurement unit for measuring a change in pressure that is increased in a specific tissue inside the organism due to the liquid substance supplied into the organism; And a display for visualizing a pressure change with respect to an injection time of the liquid material using a signal related to the pressure change transferred from the measurement unit An apparatus for injecting a liquid substance into an organism. As a method for injecting a liquid substance into the body of an animal or a plant other than a human, Measuring the volume of the liquid substance injected while injecting the liquid substance into the body of an animal or a plant, measuring the pressure in the body caused by the liquid substance injected into the body, Wherein the control unit monitors in real time the correlation of the pressure in the body according to the volume of the injected liquid material, And stopping the injection of the liquid material when the area of the decrease in the pressure change relative to the volume is observed A method of injecting a liquid substance into an organism. The method according to claim 9, further comprising: a first step of calculating a linear change period of the pressure change with respect to volume in the calculation of the change in volume versus volume; and a second step of calculating a change in plasticity of a body tissue by the liquid material injected after the linear change period And a second step of calculating a region in which the liquid material is observed. 11. The method according to claim 10, wherein the injection of the liquid substance is stopped in the region where the change in plasticity is observed. The method of claim 10, wherein calculating the volume-to-volume change comprises: monitoring the volume of the liquid material being injected and the increased pressure in the body to convert the volume and pressure information into data that graphically or tabularly displays on a display Lt; RTI ID = 0.0 > of: < / RTI > The method according to claim 9, wherein the injection of the liquid material is discontinuously performed at predetermined time intervals. As a method for injecting a liquid substance into the body of an animal or a plant other than a human, The pressure in the body is measured by the liquid substance injected while injecting the liquid substance into the animal or plant body, The correlation between the injection time and the pressure is monitored in real time to calculate the pressure change with respect to time, And stopping the injection of the liquid material when the area of the decrease in the pressure change with respect to the time is observed A method of injecting a liquid substance into an organism.

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