KR20090016085A - Material for repairing bone tissue - Google Patents

Material for repairing bone tissue Download PDF

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Publication number
KR20090016085A
KR20090016085A KR1020070080473A KR20070080473A KR20090016085A KR 20090016085 A KR20090016085 A KR 20090016085A KR 1020070080473 A KR1020070080473 A KR 1020070080473A KR 20070080473 A KR20070080473 A KR 20070080473A KR 20090016085 A KR20090016085 A KR 20090016085A
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KR
South Korea
Prior art keywords
screw
drill hole
bone
tissue repair
present
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Application number
KR1020070080473A
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Korean (ko)
Inventor
최봉섭
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최봉섭
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Application filed by 최봉섭 filed Critical 최봉섭
Priority to KR1020070080473A priority Critical patent/KR20090016085A/en
Publication of KR20090016085A publication Critical patent/KR20090016085A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

The present invention is a tissue repair material used for filling the femoral and vertebral bone defects when the screw is fixed to the thigh and the spine, and comprises a sintered body or hardened body of a calcium phosphate compound, the sintered body or hardened body, It is characterized by having strength to support the shape before and during the insertion into the drill hole, and brittleness when the screw is screwed into the sintered or hardened body after insertion and the shape is broken by the screw. The present invention can be widely used for the treatment of bone diseases in which a screw is screwed together to fix it, and particularly, even when bones such as osteoporosis do not have sufficient strength, the present invention can be effectively used.

Description

Material for tissue repair {Material for repairing bone tissue}

The present invention relates to a tissue repair material, and more particularly, to a bone tissue repair material used for filling a bone defect site such as a thigh, a spine and the like for fixation using a screw.

Screws are fixed to the bone to treat various bone diseases in humans or animals, such as bone deformation or fractures. When the bone has sufficient strength, the screw may be directly screwed onto the bone or drilled into the bone and then screwed to obtain a sufficient bond strength between the bone and the screw.

By the way, in the case of osteoporosis patients, when screwing together, there is a problem that sufficient fixation strength between the screw and the bone cannot be obtained because pores are formed in the bone.

For example, spinal posterior fixation combines screws into individual vertebrae and couples these screws to the orthodontic plate that crosses the upper and lower vertebrae. However, if the screw and bone are not strong enough, they cannot be sufficiently corrected. Or this technique cannot be performed.

For this reason, although the artificial hole material, such as apatite granules and a calcium phosphate cement, is filled in the drill hole formed in the bone (cone), the attempt to join a screw afterwards is made, but granular or The operation of filling the artificial bone material in the mud state has a problem that it is difficult to fill the required amount of artificial bone material as well as the workability is quite bad.

The present invention has been made in order to solve the above-mentioned conventional problems, and the problem of abnormality when screwing the screw to the bone, that is, the fixed strength when the screw is fastened and fixed to the bone that is not particularly strong, such as osteoporosis It is an object of the present invention to provide a tissue repair material that can easily solve the problem of deterioration.

The present invention for achieving the above object is a tissue repair material used to fill the bone defects of the thigh and spine when the screw is fixed to the thigh and spine, the sintered body or hardened body of calcium phosphate-based compound The sintered body or hardened body has a strength supporting the shape before and during insertion into a drill hole, and when screwed into the sintered body or hardened body after insertion, it is damaged by the screw and loses the shape before insertion. It is characterized by having brittleness.

More preferably, the calcium phosphate compound is composed of a sintered body of hydroxyapatite, and the porosity thereof is 40 to 80%.

More preferably, the calcium phosphate compound is composed of a cured body of hydroxyapatite, and its porosity is 20 to 70%.

More preferably, the calcium phosphate compound is molded into a columnar body having a diameter of 1.5 to 5.0 mm and a length of 15 to 60 mm.

More preferably, the columnar body has a taper angle α of 1 to 2 degrees.

More preferably, the columnar body has a drill hole for screws on its shaft portion.

More preferably, the drill hole has a taper angle β of 1 to 2 degrees.

As described above, according to the present invention, since the tissue restorative material maintains its shape prior to insertion into the bone, it can be easily inserted into the drill hole of the bone. Because of its loss of shape, the small piece is placed between the screw and the drill hole in the bone. For this reason, a screw can be firmly fixed to a bone. Therefore, the present invention can be widely used for the treatment of bone diseases in which screws are screwed together to fix bones, and particularly, even when bones such as osteoporosis do not have sufficient strength.

The bone tissue restorative material of the present invention is composed of a sintered body or hardened body of a calcium phosphate compound, and the sintered body or hardened body has a strength that supports its shape before and during insertion into a drill hole, and the sintered body or after insertion. When screwing together a hardened | cured material, it has a brittleness which is damaged by the screw and loses the shape before insertion.

According to this tissue restorative material, it is possible to easily insert into a drill hole formed in a bone. On the other hand, when the screw is tightened after insertion, the screw is broken by the tightening force and its small pieces are scattered around the screw. The powdery thing of a calcium phosphate type compound can be arrange | positioned evenly around, As a result, a screw can be fixed to bone with high intensity | strength.

The tissue restorative material of the present invention can be formed in any shape adapted to the shape of a drill hole. However, the drill hole is usually constructed from a columnar body in consideration of being drilled with a drill.

Although a columnar body differs in size according to a use site | part, it is preferable to select and use the thing whose diameter is 1.5-5.0 mm (phi) and about 15-60 mm in length.

In this columnar body, the drill hole for screws can be formed in the axial part. The drill hole has a diameter of 0.5 to 3.5 mmφ, and the length of the drill hole is preferably 1/3 or more, preferably 1/2 or more of the total length.

The present invention is composed of a calcium phosphate compound having a molar ratio of Ca / P of 1.5 to 2.0, in order to provide the necessary strength, brittleness and biocompatibility in a balanced manner. Examples of the calcium phosphate compound include apatite such as hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), fluorine apatite, tricalcium phosphate, tetracalcium phosphate, and the like. These can be mentioned, 1 type or 2 or more types can be used for them.

In the present invention, such a calcium phosphate compound is sintered and used as a sintered body, but hydraulic calcium phosphate is cured and used as a hardened body. In the case of a sintered compact, it is preferable to make porosity 40-80%, and in the case of a hardened body, it is preferable to make porosity 20-70%.

When the porosity of the sintered body is less than 40% and when the porosity of the cured body is less than 20%, the required strength is difficult to be obtained, and when the porosity of the sintered body exceeds 80% and the porosity of the hardened body exceeds 70%, inversely required brittleness is obtained. Becomes difficult.

The tissue repair material of the present invention can be produced by various methods, and the production method is not particularly limited. An example of the production method will be described by using a sintered body made of hydroxyapatite as a raw material. First, a hydroxyapatite slurry is obtained from the phosphoric acid and calcium salt by a wet synthesis method by a known method.

The obtained slurry is dried using a spray dryer to obtain a hydroxyapatite powder, and the powder is molded into the shape of the tissue repair material of the present invention by, for example, a hydrostatic press.

The molded body is fired in an electric furnace at a range of 1000 to 1200 ° C to obtain such a tissue repair material. As the molding method, a molding method, an injection molding method, a method of molding the green compact by lathe processing, etc. may be employed.

Further, for example, α-tricalcium phosphate powder is kneaded with water to which acid is added as a curing accelerator, if necessary, to produce a cured product, which is processed into the tissue restorative material shape of the present invention, or in the mold Hardened | cured material of can be produced.

EXAMPLE

Hereinafter, with reference to the accompanying drawings will be described in detail a preferred embodiment of the present invention.

1 is a perspective view showing a tissue repair material according to an embodiment of the present invention, Figure 2 is a front view showing a tissue repair material according to an embodiment of the present invention, Figure 3 is an embodiment of the present invention Fig. 4 is a schematic view showing a screw fixation method using the tissue repair material of the present invention, Fig. 5 is a schematic plan view showing the concept of spinal posterior fixation, and Fig. 6 is a posterior spinal fixation. Figure 7 is a front view showing the concept of, Figure 7 is a photograph showing a sample of a tissue repair material according to an embodiment of the present invention.

1 to 3 show examples of the shape of the tissue repair material 10 according to the present invention. The tissue restorative material 10 basically consists of a columnar portion 11, and the diameter of the tissue restoration material 10 is gradually tapered at the tip of the columnar portion 11 for the purpose of being easily inserted into a screw hole pre-punched. The taper diameter part 12 is formed.

Moreover, the drill hole 13 which has the bottom in which the taper diameter part 12 side was closed is formed in the shaft part. A chamfer 14 is formed at the open end of the drill hole 13. As shown in Figs. 2 and 3, the tissue restorative material 10 is prepared in advance in a different length L and diameter φ, and selectively used according to the length and diameter of the drill hole formed in the bone. do.

In particular, as shown in Fig. 2, the tissue repair material 10 of the present embodiment is composed of a calcium phosphate-based compound such as hydroxyapatite, and has a columnar body having a diameter of 1.5 to 5.0 mm and a length of 15 to 60 mm. It is preferred to be molded. In particular, the tissue restorative material 10, such as the thigh and the spine, has a length a of 20 mm and a diameter b and c of both ends of the columnar portion 11 having a shape of 3 to 4 mm. desirable.

In particular, the columnar body is composed of a cylindrical columnar portion 11, and preferably has a taper angle α of 1 to 2 degrees. If the data angle α is smaller than 1 °, excessive pressure may be applied to the drill hole 21 of the bone 20 to damage the columnar body. If larger than 2 °, the drill hole of the bone 20 may be damaged. It is not preferable because the filling rate for (21) is lowered.

In the columnar body, it is preferable that the drill hole 13 for the screw is formed at a predetermined depth in one shaft portion of the columnar portion 11 so that the screw 30 is screwed together.

It is preferable that such a drill hole 13 for screws also has a taper angle (beta) of 1-2 degrees similarly to the cylindrical part 11. If the data angle β is smaller than 1 °, the screwing force of the screw 30 is excessively imparted to the drill hole 13, and the upper end of the columnar body may be damaged and protrude outward. Since the filling rate according to the depth of the drill hole 21 of the bone 20 cannot be kept constant, it is not preferable.

In addition, it is preferable that the taper diameter part 12 has a taper angle (gamma) of 8-50 degrees so that it may contact with the lower end part of the drill hole 21 of the bone 20. As shown in FIG.

4 schematically shows a screw fixing method to the bone using the tissue repair material 10. A drill is first used for the bone 20 and then the drill hole 21 is drilled. The material 10 for tissue repair is inserted into this drill hole 21 by the taper diameter part 12 side.

In this insertion operation, the tissue repair material 10 maintains its cylindrical shape. When the insertion work is completed, the tip of the screw 30 is aligned with the chamfer 14 of the drill hole 13 of the tissue repair material 10, and the fastening work of the screw 30 is started.

When the screw 30 is screwed into the drill hole 13, the screwing force causes the tissue restoring material 10 to break, and loses its shape. 10 ') are scattered.

If the tissue repair material 10 is broken at an early stage, after the small hole 10 'is filled in the drill hole 21, the screw 30 is screwed into the small piece 10', A small piece 10 'is placed in a compressed state between the pores of the bone 20 and the screw 30. For this reason, the screw 30 is firmly coupled to the bone 20.

5 and 6 are conceptual views of the spinal posterior fixation. Screws 31 (particle screws) are screwed to the upper and lower vertebral bodies 22, respectively, and a calibration plate 33 common to the upper and lower vertebrae is coupled to an appropriate position of the outer protruding end of the screw 31. The tissue restoration material 10 of the present invention can be used, for example, in fastening the screw 31 to the vertebral body 22 in this spinal posterior fixation.

As shown in Fig. 7, it is preferable that the outer surface of the tissue restorative material is roughened to enhance the filling force upon screwing in the drill hole of the bone.

Next, the manufacturing example of the specific tissue repair material 10 is demonstrated.

[Production Example 1]

A hydroxyapatite slurry was wet synthesized by a known method. This slurry was dried with the spray drier to obtain hydroxyapatite powder.

The obtained powder was mold-pressed and the green compact of diameter 10mm x length 60mm was produced. The green compact was processed to a diameter of 6 mm φ, a length of 45 mm, and a drill hole 2 mm φ in the NC lathe in consideration of the plastic shrinkage, and then fired at 1100 ° C. for 2 hours in an electric furnace. The material for tissue restoration of the shape shown to FIG. 2 and FIG. 3 of 30 mm and a drill hole of 1.35 mmphi was obtained.

[Production Example 2]

The aqueous phosphoric acid solution and the calcium hydroxide suspension were reacted by a known method and dried to obtain hydroxyapatite having a molar ratio of Ca / P of 1.67. This hydroxyapatite was baked at the temperature of 1300 degreeC and the pressure of 1.3 * 10 <-4> Pa for 1 hour.

As a result, a mixture of α-tricalcium phosphate and tetracalcium phosphate produced by pyrolysis of hydroxyapatite was obtained. A mixture of α-calcium triphosphate and tetracalcium phosphate thus obtained was used as a powder, an aqueous solution containing 47% citric acid, 17% glucose and 7% chitosan, and a separation ratio 2 : 1 was kneaded.

The dough was placed in a split mold (made of polyacetal) drawn into a tapered shaft shape having a diameter of 10 mm on the insertion side, a diameter of 15 mm on the upper surface, and a length of 75 mm, and cured for about 10 minutes. After hardening completely after that, it was taken out of the mold and obtained the desired cylindrical hardened body. A drill hole having a diameter of 1.35 mm was further processed into this cured product to obtain a tissue repair material having a shape shown in FIGS. 2 and 3.

The present invention described above can be embodied in many other forms without departing from the spirit or main features thereof. Therefore, the above embodiments are merely examples in all respects and should not be interpreted limitedly.

1 is a perspective view showing a material for tissue repair according to an embodiment of the present invention.

Figure 2 is a front view showing an example of a tissue repair material according to an embodiment of the present invention.

Figure 3 is a front view showing another example of the tissue repair material according to an embodiment of the present invention.

Figure 4 is a schematic diagram showing a screw fixing method using a tissue repair material of the present invention.

5 is a schematic plan view illustrating the concept of posterior spinal fixation.

Fig. 6 is a front view showing the concept of posterior spinal fixation.

Figure 7 is a photograph showing a sample of tissue repair material according to an embodiment of the present invention.

<Description of the symbols for the main parts of the drawings>

10: material for tissue restoration 11: columnar portion

12: taper diameter part 13: drill hole

20: bone 21: drill hole

30: screw

Claims (7)

As a material for tissue repair used to fill the femoral and spinal bone defects in the case of fixing the screw to the thigh and the spine, It consists of a sintered body or hardened body of a calcium phosphate compound, the sintered body or hardened body having strength to support the shape before and during insertion into a drill hole, and when screwing the screw into the sintered body or hardened body after insertion. A material for tissue repair characterized in that it has brittleness that is damaged by the damage and loses its shape before insertion. The method of claim 1, The calcium phosphate compound is composed of a sintered body of hydroxyapatite, and the porosity thereof is 40 to 80%. The method of claim 1, The calcium phosphate compound is composed of a cured body of hydroxyapatite and has a porosity of 20 to 70%. The method according to any one of claims 1 to 3, The calcium phosphate compound is formed into a columnar body having a diameter of 1.5 to 5.0 mm and a length of 15 to 60 mm. The method of claim 4, wherein The columnar body has a taper angle α of 1 to 2 °. The method of claim 4, wherein The columnar body has a drill hole for screws on its shaft portion, the material for tissue repair. The method of claim 6, The said drill hole has a taper angle (beta) of 1-2 degrees, The tissue repair material characterized by the above-mentioned.
KR1020070080473A 2007-08-10 2007-08-10 Material for repairing bone tissue KR20090016085A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120004594A1 (en) * 2010-07-02 2012-01-05 Wright Medical Technology, Inc. Methods of treating degenerative bone conditions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120004594A1 (en) * 2010-07-02 2012-01-05 Wright Medical Technology, Inc. Methods of treating degenerative bone conditions
US9550010B2 (en) * 2010-07-02 2017-01-24 Agnovos Healthcare, Llc Methods of treating degenerative bone conditions

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