KR20090013141A - Mechanical skin resurfacing device and method for use - Google Patents

Abstract

A mechanical skin regeneration apparatus and a method for using the same are provided, which obtain the cell proliferation, the minute peel-away effect, the washing etc. A skin regeneration method comprises: a step for providing the energy to minute vibration device by moving the mass less than 4g to the eccentric orbit; and a step for contacting the skin to the vibrating release agent. The enough energy rotates the axis of the motor of minute vibration device. Accordingly, the mass moves to the eccentricity orbit.

Description

Mechanical skin resurfacing device and method for use

The present invention relates to a method for skin regeneration comprising contacting the skin with a vibrating release agent using a micromotor.

Various techniques have been proposed to provide cosmetic and / or skin regeneration benefits. As one of the more popular techniques, professional microdermabrasion is a non-invasive method in which the device pulls the skin through inhalation and impacts the skin with exfoliating particles to perform peeling. However, specialized microdermabrasion devices are disadvantageous in that they occupy huge space and also require high power input and must be plugged into an AC outlet during operation. In addition, patients should visit their skin care professional regularly. Thus, "home" microdermabrasion systems incorporating a transmission and a stripping system are currently available.

US Patent No. 6,652,888 to Rhoades discloses a method for skin regeneration using abrasive creams. In this method, a moisturizer cream for regenerating human skin is provided with a suspension of alumina microcrystals at a rate of approximately 14 g per ounce of moisturizer cream. The moisturizer cream is polished in the epidermal layer of the skin by a closed foam sponge pad driven by a vibrator. Alumina microcrystals regenerate the skin by polishing the epidermal layer of the skin to provide a smooth, smooth surface.

US Pat. No. 6,139,553 to Dotan discloses facial skin treatment tools and methods. This patent discloses facial skin treatment tools and methods that apply a facial composition containing a release agent to the face, press the face treatment head against the facial composition, and then vibrate to cause the facial composition to function in the skin of the user's face. Preferably, the facial treatment head includes a convex curved surface and may include a rotating disk that rotates and vibrates while being pressed and in contact with the facial composition on the user's face. The facial composition is preferably a mud mixture, followed by further treatment with a moisturizer-containing facial composition that preferably acts in the skin in a manner similar to the mud treatment.

US 6,645,184 to Zelickson discloses a tape stripping system and method. The system attaches a tape-like material to human skin and then peels off the tape from the skin to remove unwanted excess material. The system further includes applying other members to facilitate the recovery and regeneration process of the skin.

The inventors have recognized that "household" microdermabrasion systems are commercially available and that these systems are effective but may, for various reasons, fall short of optimization. These devices are rather large because smaller devices are less effective. However, the inventors also recognized that commercially available "home" microdermabrasion systems are often rather heavy and / or bulky, making them difficult to handle, invisible to the skin surface to be treated, and unnecessarily high packaging costs. The inventors further found that it is necessary to overcome one or more of the above mentioned disadvantages while still maintaining the efficacy of skin treatment.

In one aspect, a method of skin regeneration is provided. The method involves moving a mass of less than 4 g in an eccentric orbit to provide sufficient energy to the micromotor to cause the release agent bound to the device to vibrate. In addition, the method includes positioning the vibrating release agent in contact with the skin.

By using the method of the present invention, various benefits such as cell proliferation, microdermabrasion, washing and the like can be provided with the additional convenience of using a skin regeneration device manufactured in a compact, individual, light weight and low cost.

Those skilled in the art believe that the present invention may be utilized as fully as possible based on the description herein. The specific aspects below are provided for illustrative purposes only and are not meant to limit the rest of the description in any way.

In the present specification and claims, "mechanical skin regeneration techniques" and similar terms refer to mammals (particularly from light techniques through microdermabrasion (e.g., dermabrasion and exfoliation cleaning) to advanced techniques such as skin exfoliation. Human) means mechanical removal of skin cells.

"Dermabrasion" and similar terms in this specification and claims refer to non-thermal regeneration techniques that are particularly suitable for large defects that make skin conditions look bad, such as acne scars, deep wrinkles and injection ratios. This method involves mechanical polishing of the upper layer of skin and penetrates the skin deeper than microdermabrasion. A new skin layer replaces the peeled skin in the healing process by the exfoliation to provide a smoother appearance.

In the present specification and in the claims, "microdermabrasion" and similar terms mean exfoliation in a very light and less penetrating form that is more suitable for fine lines, wrinkles and other less severe skin conditions. Microdermabrasion mainly penetrates deeply through the stratum corneum or part of the skin.

The term "dermabrasion" and similar terms in this specification and claims means peeling off tissue cells of the skin.

The term "clean" and similar terms in this specification and claims means the removal of dirt, oil, and the like from the surface of the skin, in particular through surfactant cleaning, and also penetrates into the pores of the skin. In "peel cleansing," some peeling may also occur.

These mechanical skin treatments can facilitate delivery of effective agents such as cleansing agents and acne treatment compositions or regenerative agents such as retinol to skin tissue.

In this specification and in the claims, “nonwovens” and similar terms mean sheets, webs, or batting of natural and / or synthetic fibers or filaments, except paper, which is not converted to yarn and bonded to each other by any of a variety of means. To illustrate further, nonwovens are distinguished from woven and knitted fabrics. The fibers included in the nonwoven material may be staples or continuous fibers or may be formed in the reactor, preferably at least about 50% of the fibrous mass is provided by fibers having a length to diameter ratio of greater than about 300: 1.

The present invention relates to systems, articles, compositions and methods useful in mechanical skin regeneration techniques using small powertrains. In various aspects of the present invention, such systems, articles, and methods uniquely provide high reliability and convenience for the user and provide highly efficient mechanical skin regeneration techniques.

1 is a side view showing an example of a non-limiting system 1 useful for mechanical skin regeneration according to aspects of the invention described herein. The system 1 generally comprises a transmission 3 in the form of a user's hand.

The device 3 can have various shapes and dimensions, a notable form being a curved tubular shape comprising a convex handle surface 5. The convex handle surface 5 is convex away from the volume center of the device 3 and terminates at the base surface 7.

2 is a front view of system 1. FIG. The device 3 may comprise one or more surfaces 19 for removably bonding the skin contact member. The terms "removably bonded" and similar terms mean that the member can be adhered, removed and reattached without significantly weakening the adhesive strength.

FIG. 3 shows an independent mass such as a skin contact member 9 (eg, sponge, fiber material or other material or combinations thereof including those described herein) comprising a skin contact surface 11 for contacting the skin. (mass)). The skin contact member 9 can be placed and fixed on any carrier 13 (eg a rigid plastic substrate) (as indicated by the arrow in FIG. 3). The skin contact member 9 can be secured to the carrier by any of various means such as microhooks, adhesives and the like. The carrier 13 may be detachably removable to one or more surfaces 19 of the device 3 via snaps, threaded screws, friction fixtures, and the like.

FIG. 4 is a cross-sectional view taken along the line 1-1 ′ virtually shown in FIG. 1. The user holding the handle surface 5 can operate the motor 21 with the energy stored in the battery 27 by actuating the switch 17 on the device 3 to start the motor 21 in the device 3. have. The motor 21 thus operated provides the mechanical energy delivered to the adhered skin contacting surface 11 and the large area (not shown) of the skin in contact with the surface. The mechanical energy comprises a form of vibration that is transmitted through the eccentric weight 23 on the axis of rotation 25. The handle surface 5 is generally oriented so that the device 3 is brought into contact with the user's skin such that the vibrating skin contact surface 11 attached and shaped is easily gripped by the user.

In order to facilitate the transfer of energy from the motor to the skin contact member 9, the motor 21 can be placed in the immediate vicinity of the skin contact member 9 (FIG. 5 shows a perspective view of a suitable motor). As shown in FIG. 4, the axis of the axis 25 is preferably parallel to the skin contact surface 11, but it is not necessary.

Applicants have found the surprising fact that the vibration energy provided by the device 3 does not have to be high to provide efficacy to the skin. In particular, Applicants have found that a mass of less than 4 g can provide sufficient micropeelment when used with a release agent. In one embodiment, the mass of the eccentric weight is less than about 3 g. In another embodiment, the mass of the eccentric weight is less than about 2 g. In another embodiment, the mass of the eccentric weight is about 1.6 g to about 4 g.

The inventors have found that the device of the present invention can reduce the mass 23 of the eccentric weight, thus achieving microdermabrasion as well as adjusting the design of the device to achieve other advantages. Specifically, by reducing the mass of the eccentric weight 23, (1) the space occupied by the motor and the space occupied by the entire device is reduced, making the skin area more visible when using the device, and (2) making the device easier to carry. , (3) reduce packaging costs in manufacturing the device, and (4) reduce the weight of the device (3), making it lighter and less difficult to hold over long periods of use.

According to an aspect of the present invention, the vibrational release agent is placed in contact with the skin to be treated. Although the said figure shows a peeling agent as a peeling skin contact member, it is not necessarily required. The release agent may be, for example, mineral particles such as aluminum oxide, mica, silicate, and the like, and particles for organic release such as organic peeling particles such as walnut shell powder, apricot shell powder, and the like, and inorganic particle powder.

In order to avoid the difficulty of removing / cleaning the glass peeling particles after use, in a preferred embodiment, the release agent is a peeling skin contact member such as the skin contact member 9 described with reference to the above drawings. The peeling skin contact member is a mass, such as a sponge, a fibrous material or other material, or a combination thereof, that is present independently of the skin, having a peeling system inherent or bonded thereto.

The peeling skin contact member 9 may comprise, consist essentially of, or consist of a fibrous material. Suitable fiber materials include, but are not limited to, woven fabrics, nonwovens (eg, nonwovens oriented or unoriented through a carding process) or knits. Fibers can be, for example, needle punching, through-air bonding, hydroentangling, spun-bonding, chemical bonding (including adhesive bonding), or mechanical processing ( Embossing) into a nonwoven structure.

In this way the fibers can be arranged into independently existing fabrics, such as porous fabrics. The nonwoven fabric may have an average pore diameter of about 150 μm to about 500 μm, for example about 220 μm to about 400 μm (see Cohen, "A Wet Pore-Size Model for Coverstock Fabrics," Book of Papers). : The International Nonwovens Fabrics Industry, pp. 317-330, 1990). Representative non-limiting examples of useful fibers include, for example, fibers and bicomponent fibers obtained from organic polymers such as polyesters, polyolefins, polyamides, and rayon fibers; Cellulose based fibers such as wood pulp, rayon and cotton; And combinations thereof.

In order to provide a particularly suitable degree of peeling, the skin contact member 9 may be formed from about 0.5 mm to about 5 mm, more preferably from about 1 mm to about 5 mm, by mechanical means, such as needle punching processes known to those skilled in the art. It may comprise fibers bonded to a thickness. The fiber material may have a sufficient reference weight (mass per unit area) to maintain mechanical integrity for the use of one or more skin contact members 29. The basis weight can be, for example, about 10 g / square meter (gsm) to about 450 gsm, for example, about 200 gsm to about 400 gsm, preferably about 300 to about 400 gsm. The fibrous material preferably includes rayon to provide softness and preferably includes a highly elastic material such as olefins or polyesters. A particularly notable fiber material is a blend of needle punched staple-length 1.5 denier "TENCEL" rayon and staple-length 4-5 day PET with a basis weight of about 200 gsm to about 400 gsm (Precision Custom Coating, Totowa, NJ )to be.

The bonded release agent may be a release system bonded to the fibers. By "bonded to a fiber" is meant a release unit, particles, aggregates, etc. that are firmly adhered to the fiber and do not easily fall off therein during use. Such release agents can be bound by various means, notable means being chemical bonding (including without limitation adhesive bonding).

The stripping system comprises or consists essentially of a water insoluble stripping material. In one embodiment of the invention, the peeling system comprises a resin or a polymer. For example, the polymer may be a homopolymer, copolymer or terpolymer and may be a blend of two or more different polymers. The polymer may have a random, block, constellation or other known structure. The polymer may be prepared by known means such as emulsion polymerization, dispersion, suspension or solution polymerization. In a preferred embodiment the polymer is formed by emulsion polymerization. The polymer may be nonfunctional or contain functional groups designed to optimize coating properties in certain applications. Those skilled in the art will be able to adjust the monomer content and structure to improve the final performance of the polymer composition. The polymer may be a synthetic polymer or may be a natural polymer such as, for example, polysaccharide, starch, modified starch or guar gum. Preferred polymers include at least one of (meth) acrylates, maleates, (meth) acrylamides, vinyl esters, itaconates, styrenes, unsaturated hydrocarbons and acrylonitriles, nitrogen functional monomers, vinyl esters, alcohol functional monomers Homopolymers and copolymers with monomers are included. Particularly preferred monomers include, without limitation, vinyl acetate, methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, ethylene, vinyl chloride and styrene.

The polymer is selected so as to provide sufficient strength to the skin when included in the skin contact member, but not so hard that it gives scratches or discomfort. In one embodiment of the invention, the polymer has a glass transition temperature T _g of at least about −20 ° C., for example from about 0 ° C. to about 105 ° C. In one notable embodiment the polymer has a T _g of about 0 ° C. to about 50 ° C.

T _g can be measured by differential scanning calorimetry (DSC) performed at a heating rate of 20.0 ° C./min using a sample of 5 mg or less. T _g is calculated as the midpoint between the beginning and the end of the heat flow change corresponding to the glass transition on the DSC heat capacity heating curve. The use of DSC for T _g measurements is well known in the art (see B. Cassel and MP DiVito, "Use of DSC To Obtain Accurate Thermodynamic and Kinetic Data", American Laboratory, January 1994, 14-19). , And B. Wunderlich, Thermal Analysis, Academic Press, Inc., 1990).

The polymer may be a thermoset polymer (eg, a polymer that generally has a crosslink reversible to temperature changes). Notable polymers have an acrylic substrate / vinyl acrylic substrate with a T _{g of} about 30 ° C. that is partially crosslinked during curing, such as VINAMUL ABX 30 from Celanese Corporation, Dallas, TX.

The stripping system may further comprise one or more additional functional ingredients combined with the stripping agent. Useful additional functional ingredients include, without limitation, plasticizers, crosslinkers, starches, polyvinyl alcohols, formaldehyde thermosets (e.g. melamine, urea, phenols), fillers, humectants, surfactants, salts, fragrances, and pigments or reflective Ingredients are included. The additional functional component may be present in the stripping system at 0 to 20% by weight, preferably 5 to 15% by weight, calculated as a percentage of polymer solids.

The skin contact member 49 may be formed by depositing the release system 43 on the fibers 45 by various means known in the polymer coating industry, such as slot coating, foam coating, saturation, printing or spraying. Spraying is especially noteworthy because it promotes the formation of separate release agent units on top of the fibers, thereby reducing waste and maximizing efficiency. When applying the peel system by spraying, the spray composition comprising the peel system (e.g., a mixture of polymer and other functional ingredients with water or other suitable carrier) is first sprayed onto the fibers and then the resulting fiber / releasing agent composite It can be dried in a conventional oven.

While the foregoing has described skin contact members including a peeling system bonded to the fibers, in one aspect of the invention the fibers themselves may be peeling agents without the need to include additional peeling systems bound to the fibers. For example, in one particular embodiment, the skin contact member comprises staple fibers integrated into the nonwoven structure through needle punching, through air bonding, or thermal bonding. Fibers include polyesters, polyolefins, rayon fibers, bicomponent fibers; Cellulose based fibers such as wood pulp, rayon and cotton; Or high denier fibers formed from combinations thereof.

The present inventors can achieve desirable properties by using suitable peelable skin contact members having a suitable "Durable Abrasiveness" measured according to the "Durability Abrasion Test" described in the section "Test Methods" below. I found a surprising fact. In addition, the above-mentioned effects are further enhanced when the skin contact member is selected in consideration of one or more properties, in particular Compressiblity and Displacement, in relation to their behavior under compression load, in combination with their durability peelability. This property relates to the ability of the skin contact member to transfer mechanical energy from the device 3 to the skin contact surface in a wet or wet environment to mechanically regenerate the skin.

In one embodiment, the skin contact member has a durability exfoliation degree of 2 to 14, preferably about 2.5 to about 12, more preferably about 3 to about 10, particularly preferably about 4 to about 9.

The inventors have found that improved peelable skin contact members (particularly skin contact members that meet certain peelability criteria as described above) have improved performance when used with mechanical tools when they have additional properties relating to their behavior under applied compressive loads. I also found the surprising fact that In particular, the skin contact member provides some displacement under the applied load but is not overly displaced.

Displacement and compressibility of generally recoverable deformations due to the applied compressive force are additional properties useful for characterizing skin contact members. These properties can be measured according to the "compression rate and displacement test" described in the section "Test method" below.

As such, in one embodiment the skin contact member is from 0.15 mm to about 2.0 mm, preferably from about 0.25 mm to about 1 mm, more preferably from about 0.25 mm to about 0.8 mm, most preferably from about 0.25 mm to It has a displacement of about 0.5 mm.

The inventors have also surprisingly found that moderate peeling skin contact members have a compressibility but not excessively. As such, in one embodiment the skin contact member has a compressibility of less than about 20%. In other embodiments, the compressibility may be less than about 19%, preferably less than about 15%. More preferably, the compressibility may range from about 3% to about 13%.

The present inventors have a skin having a thickness of about 0.1 mm to about 20 mm, preferably about 0.5 mm to about 5 mm, more preferably about 1 mm to about 5 mm, most preferably about 1.5 mm to about 4.5 mm. It has also been found that the contact member is desirable. The thickness can be measured as the "initial thickness" in the following compressibility and displacement tests. Other suitable properties of skin contact members are described in commonly assigned US Patent Application Publication No. US20070010828 "Material for Mechanical Skin Resurfacing Techniques", which is incorporated herein by reference.

Skin contact member 9 may further comprise a coating formed around or across the fibers, in one embodiment being formed over the fibers 45 and over the release system. The coating may be at least partially water soluble such that, in use, one or more components in the coating may dissolve and be delivered to the skin 19. In one embodiment of the invention the coating is substantially free of release agents such as release particles that can be delivered to the skin and deeply embedded. In one embodiment of the invention the coating is substantially free of water (ie, contains less than about 2%, for example less than about 0.5% water).

The coating can provide one or more of several functions. For example, the coating may be lubricating, softening and / or moisturizing; Soft foaming; Excipients for delivering various effective agents (eg, active agents, drugs, etc.); Or a combination thereof.

In addition, the coating 53 may be one or more effective agents such as anti acne agents, anti-wrinkle agents, antibacterial agents, antifungal agents, anti-inflammatory agents, local anesthetics, artificial tanning agents, accelerators, antiviral agents, enzymes, sunscreen agents, antioxidants, dermabrasion agents, hair loss agents, and the like. It may include a medicament. Other suitable active agents are co-pending patent application US 2005-0148907 filed on December 24, 2003 (title "TREATMENT OF SKIN USING A BENEFIT AGENT AND AN APPARATUS"), and filed December 28, 2004. Co-pending patent application Serial No. 11/023655 (title "SKIN TREATMENT ARTICLES AND METHODS").

How to use

The system 1 of the present invention can be used to treat skin such as peeling, rinsing or other skin treatments (e.g. acne, anti-aging, firming, skin tone and skin texture, hair loss, body correction / cellulite removal, etc.). have.

In one aspect of the invention, the skin contact member is temporarily glued to the compact transmission. In other embodiments the skin contact member provides exfoliation and does not require additional exfoliants. In other embodiments, compositions comprising exfoliated particles (eg, suspensions, emulsions, etc.) may be added to the skin contact member or to the skin to be treated.

The user grabs the device and switches on the device to rotate the axis of the motor to impose sufficient energy on the device to cause the eccentric weight associated therewith to move in the eccentric orbit around the axis. In this way, the vibration energy generated from the rotating eccentric weight is transferred to the release agent. Vibrating release agents provide benefits in contact with the skin.

Vibration releasing agents are exercised over other areas of the face or skin to be treated. For example, skin contact surface 11 (eg, substantially planar skin contact surface) is positioned to contact the skin to be treated. The skin contact member provides increased cell proliferation, for example by exfoliating the skin. The skin contact member may comprise a formulation for providing softening, foaming, or delivery of an effective agent to the skin. When finished, the skin contact member can be removed and replaced with a new one to provide a hygienic surface. After use, the treated skin may be optionally cleaned.

By using the method of the present invention, the present inventors can be provided with a variety of advantages, such as cell proliferation, microdermabrasion, washing, etc., with the additional convenience of using devices manufactured in a small, individual, light weight, and low cost in certain embodiments.

Test Methods

Peelability Test

"Durable peeling degree" is measured using the test method described below. The “general peelability” of the material is measured in a similar way to the durability peelability but omits the initial cleaning step.

Five test samples of each skin contact member are cut out in a circle having a diameter of about 41 mm. The samples are individually rinsed with water to remove any materials such as blowing agents, oils and emulsifiers that are easily separated from the article through contact with water. The cut sample is immersed in a deionized water-containing bath (temperature of about 35 ° C.) containing sufficient water having a mass of at least about 20 times the mass of the article. Immerse the article in the bath for 2 minutes, remove it, let it drip for 10 seconds, place it in another similar (newly prepared) bath for 2 minutes and let it drip for 5 minutes. The sample is taken out and dried at ambient temperature (about 50-60% relative humidity) for about 16 hours to about 72 hours. This washing step is omitted when measuring general peelability.

After washing and drying the sample as above, the peelability is tested using a peel test apparatus according to ASTM Test Method D 3886-99 of the improved form. Suitable apparatus is CSI Fabric Abrasion Tester, Model CS-226-605 from Custom Scientific Instruments, Whippany, NJ. Sample of co-extruded spunbonded / colored polyethylene film laminate [Clopay M18-1057, manufactured by Clopay Plastic Products, Mason, OH, (1) 15 gsm (nominal) spunbonded polypropylene nonwoven web layer and (2) approximately 0.7 mils thick (0.007 inch) 20 gsm (nominal) polyethylene film co-extruded together with 26 gsm laminate, the polyethylene film surface of the laminate being corona treated, the laminate having a target bond strength of 150 g / inch] Place the laminate on the stage, and secure the laminate to the stage using an O-ring mounted to the wear tester. The sample is fixed on the crosspiece above the stage so that it is aligned directly on top of the stage. Secure the sample with sturdy double-sided tape (e.g. PERMACEL tape, Permacel Company, East Brunswick, NJ) to prevent the sample from moving when the tester is running. Load 10 lbs of weight onto the stage and turn on the motor of the tester. The stage rotates and translates in unison at a rate of about 130 cycles / minute. Record the number of failure cycles as the first cycle of tearing of the film (colored, for example, white spunbonds are readily visible to the blue film to indicate the end of the test). Repeat this process for the remaining samples. The average number of failure cycles is recorded and the "durability peelability" (for washed samples) or "typical peelability" (for unwashed samples) is calculated as 2000 divided by the average failure cycle.

As a reference for each data set, it is preferable to use a standard sample SCOTCH-BRITE pad ("Heavy Duty Commercial Scoring Pad" No. 86). Scotch-Bright Pad No. 86 will provide a Durability Peel Value of approximately 33 ± 4. In the case where the durability peeling degree outside this range is measured, this appears to be a minor error of the operator, and the operator must adjust the method of measuring the subsequent durability peeling degree by a factor correcting this error. The factor is (V / 33), where V is the value measured by the operator for Scotch-Bright Pad No. 86. If Scotch-Bright Pad No. 86 is not available, Scotch-Bright Pads ("General Purpose Commercial Scoring Pad" No. 96) with an expected endurance of 14 ± 2 may be used instead as a standard sample. The calibration factor when the standard sample is not within the specified range is (V / 14).

Peelability values for the five samples are averaged and recorded as the durability or general peelability values for specific skin contact members.

Compression Ratio and Displacement Test

"Displacement" is measured using the following test method. Five samples are cut to a diameter of about 41 mm for each test article. One at a time, the samples were placed on a thickness meter such as Ames Logic Plus (model LG3601-1-04, manufactured by BC Ames, Waltham, MA), and the samples were placed under a 55 mm foot. In the middle of the. Place a 0.5 oz weight on the shaft and gently lower the foot onto the sample. Allow the meter to stabilize for 10 seconds and record the "Initial Thickness". The foot is then lifted to replace the 0.5 oz weight with 8 oz weight. Allow the meter to stabilize for 10 seconds and record the "load thickness". This process is repeated for 10 samples. For each sample, calculate and record the difference between the initial thickness and the thickness under load. The results for the ten samples are averaged and recorded as the displacement for the particular skin contact member.

"Compression rate" is calculated as the displacement of the sample divided by its initial thickness and expressed as a percentage. The results for 10 samples are averaged and recorded as the compressibility for the particular skin contact member.

Example

The following examples relate to skin contact members of the present invention. Those skilled in the art can make other aspects of the present invention in a similar manner.

Comparative Example 1

Independently present fibrous nonwoven material (white-off-white needlepunch nonwoven material made from a blend of polyester and Lyocel® fibers; nominal reference mass of 9 oz / yd2 (300 gsm), which is a binderless nonwoven , 50% polyester fiber and 50% Lyocel® fiber).

Composition of Sprayed Binder Solution ingredient weight% Robin & Haas Rhoplex TR-407 80.00 National Starch Alcogum 296 W 0.30 Water (adjusted as needed) 19.30 Eckart Sparkling Silver Mica 0.20 Gordon Labs Alum Oxide Code # 1000999 0.10 Blue / Purple (Sun BCD9680) Pigment Solution 0.10 (est.) BASE Luprintol 06-5920 * (adjusted to pH 6.5-7.0) 0.30 (est.only if needed)

* Or Angus Chemical AMP-95

The final binder in the fiber is 1.6 osy (54 gsm) and water is removed.

The nonwoven / release agent composite is then cut into round pads 41 mm in diameter. The cleaning composition was then coated all over the top surface of the composite nonwoven / relaxer system. The cleaning composition comprises the following ingredients:

product name Chemical name % (w / w) Texapon NC70 Sodium laureth sulfate 15.0000 Tegobetaine F-50 Cocamidopropyl Betaine 6.0000 Plantaren 2000 N Decyl glucoside 5.0000 Monateric 949J Disodium Lauro Ampodiacetate 7.0000 Atlas G-4280 PEG-80 sorbitan laurate 20.0000 Glucquat 125 Lauryl methyl glutet-10 hydroxypropylammonium chloride 1.0000 Phenoxetol Phenoxyethanol 0.9000 Nipa butyl Butyl paraben 0.0750 Methyl Paraben Methyl paraben 0.1550 Propyl paraben Profile paraben 0.1000 Fragrance air freshener 0.6000 Citric acid anhydrous Citric acid 0.2000 Carbowax PEG 400 Polyethylene glycol 10.9700 Emery 917 glycerin 33.0000

PEG-80 sorbitan laurate and disodium lauroampodiacetate were added together in a beaker and mixed until homogeneous. Butyl paraben, methyl paraben and propyl paraben were added and mixed slowly until the paraben dissolved. Then PEG-8 and glucquat were added to the beaker and mixed. Cocamidopropyl betaine, sodium laureth sulfate, decyl glucoside and phenoxyethanol were then added and mixed. Subsequently, perfume was added. Citric acid was then added and the components were mixed until the citric acid was completely dissolved. The pH was adjusted to 6.4 to 7.2.

The skin contact member 1 was placed on an apparatus for peeling off the skin using a transmission device. The powertrain is commercially available from Neutrogena Corporation (Los Angeles, CA) under the trade name "NEUTROGENA Advanced Solutions ™ At Home MicroDermabrasion System." *** The speed setting used is "high". The device has a motor axially oriented parallel to the skin contact member and has an eccentric mass of 4.0 g.

The skin contact member described above for Example 1 was placed on a conventional apparatus for peeling off the skin. Clinical evaluation was performed by 12 subjects with microdermabrasion once every two days at home. Each subject tested the system described in Example 1 on one side of the face and the one described in Comparative Example 1 on the other side. Immediately before starting the clinical study, after 1 day, after 7 days and after 14 days, clinical evaluation was performed. The increase in skin proliferation was measured by a method similar to that described in US 5,456,260 ["Fluorescence detection of cell proliferation" assigned to General Hospital Corporation), incorporated by reference,

Example 1

The skin contact member was prepared in the same manner as described in Comparative Example 1. The device used for clinical treatment was structured by retrofitting the "NEUTROGENA Advanced Solutions ™ At Home MicroDermabrasion System". The following device: The device housing was disassembled by removing the five threaded fasteners, digging in half in two along the dividing line. The original motor and motor housing were removed. An alternative motor, JameCo # 175062, is offered with an eccentric mass of 1.4 g. The motor is attached to the inner surface of the device using epoxy and the motor is oriented the same as in the comparative example. The applicator housing has been restructured into the original threaded lock. The head disk is attached with silicone epoxy.

Cell proliferation results are provided below:

The t-test performed whether there was a difference between each treatment and baseline as well as a statistical difference between the two treatments. After 1 week (3 treatments), both Comparative Example 1 and Example 1 of the invention show an increase in statistical cell proliferation relative to baseline. Both treatments are not statistically different at any time during the study. Surprisingly, the replacement of the micromotor (low eccentric weight) did not statistically reduce the cell proliferation provided by the treatment.

DETAILED DESCRIPTION OF THE INVENTION The present invention briefly summarized above will be described in more detail with respect to aspects thereof with reference to the accompanying drawings. It is to be understood, however, that the appended drawings are merely illustrative of exemplary embodiments of the present invention and do not limit the scope thereof, and that the present invention may include other aspects having equivalent effects.

1 is a schematic side view of a system for skin treatment consistent with aspects of the invention described herein.

2 is a front view of the system of FIG.

3 is a top view of a skin contact member suitable for use in the system of FIG. 1.

4 is a cross-sectional view taken along the line 1-1 ′ of FIG. 1.

5 is a perspective view of a motor suitable for use in the system of FIG. 1.

Claims (16)

a) moving a mass of less than 4 g in an eccentric orbit to provide sufficient energy to the transmission to cause the release agent coupled to the device to vibrate; b) contacting the skin with a vibrating release agent. The method of claim 1 wherein the mass is less than about 3 g. The method of claim 2 wherein the mass is less than about 2 g. The method of claim 1 wherein sufficient energy causes the axis of the motor of the device to rotate, thereby causing the mass to move in an eccentric orbit. The method of claim 1 wherein the vibrational release agent is a vibrating skin contact member. The method of claim 5 wherein the Durable Abrasiveness of the peelable skin contact member is between 2 and 14. The method of claim 5 wherein the displacement of the peelable skin contact member is from about 0.2 mm to about 2.0 mm. The method of claim 7 wherein the displacement of the peelable skin contact member is from about 0.25 mm to about 1.0 mm. The method of claim 5, wherein the compressibility of the peelable skin contact member is less than about 20%. The method of claim 5 wherein the peelability of the peelable skin contact member is from about 1 to about 14, and the compressibility is from about 7% to about 18%. 6. The method of claim 5 wherein the peelable skin contact member comprises a porous mass. The method of claim 11, wherein the peelable skin contact member comprises a fibrous mass. The method of claim 12, wherein the fibrous mass comprises a needlepunched web. The method of claim 12 wherein the fibrous mass comprises a release agent bound. The method of claim 1, further comprising c) moving the device to contact the release agent with various other parts of the skin. The method according to claim 6, wherein the peelability of the peelable skin contact member is 3 to 10.

Images