KR20080107799A - Toothpaste with stabilized peroxide - Google Patents

Abstract

A dentifrice composition is provided to improve the stability of peroxides, to prevent the acidity of a dentifrice, to improve the whitening effect of tooth of a dentifrice and to minimize the contact of teeth with peroxides. A dentifrice composition comprise a film which comprises a peroxide layer which contains a peroxide; and a support layer which protects the peroxide layer. Preferably the film comprises at least three layers. Preferably the support layer is formed at both sides of the peroxide layer. Preferably the peroxide layer comprises at least one polymer stabilizing peroxides selected from the group consisting of polyalkylvinyl ether-maleic acid copolymer, polyvinyl alcohol, polyacrylic acid, polyethylene oxide, polyvinyl pyrrolidone-vinyl acetate copolymer polyvinyl pyrrolidone, polyquaternium-11, polyquaternium-39, and carboxy polymethylene (carbomer, carbopol).

Description

Toothpaste stabilized with peroxide {TOOTHPASTE WITH STABILIZED PEROXIDE}

The present invention relates to a peroxide stabilized toothpaste, and more particularly, by stabilizing peroxide effective in tooth whitening and introducing into toothpaste, toothpaste does not show acidity and helps to ensure dental health while ensuring the stability of peroxides. It is related to toothpaste with improved whitening performance.

Teeth are porous minerals, and there are various causes of tooth discoloration, including drug, smoking, and food coloring. The reason the tooth is colored other than white is due to the characteristics of the porous tooth, in which the colored material is deposited in the microcavity inside the tooth, and as the materials accumulate, it is colored other than white. .

People want white teeth for cosmetic or other reasons, and several teeth whitening methods have been developed and developed since the first standardized tooth whitening method was done at the dentist in the late 1960s. Among the various whitening methods studied so far, peroxide is mainly used. Toothpaste containing tooth peroxide or hydrogen peroxide as a main component of toothpaste is typical, and dental whitening agent is sometimes used in trays. .

However, the dental whitening method that is performed at the dentist is expensive and has the inconvenience of having to go directly to the consumer. On the other hand, in the case of the tooth-adhesive whitening agent, the price has been considerably lower than that of the dental procedure, but there is a hassle that needs to be attached directly with one hour or more of effort every day. Considering this, if the peroxide is directly added to the toothpaste, it is expected to be effective in terms of cost and effort as the whitening effect using the peroxide can be expected during the brushing time.

However, in general, peroxides are not stable, and when they encounter a specific material including metal ions, they are rapidly decomposed. Accordingly, efforts have been made to stabilize peroxides in various oral products. In particular, peroxides tend to be stable in acidity. If toothpaste is acidic, the tooth may be corroded and the tooth may be easily broken or etched by acid, which may threaten dental health. Therefore, in the case of a toothpaste containing a peroxide, it is necessary to stabilize the peroxide without being acidic.

US Patent No. 5,085,853 and Korean Patent No. 10-0444893 aim to stabilize hydrogen peroxide through a double vessel. That is, while putting the components that interfere with the stabilization of the peroxide in another container, there is a problem that the same amount comes out when using, and the manufacturing cost is expensive. In addition, the Republic of Korea Patent No. 10-0179525 proposes a whitening toothpaste in the capsule, there is a problem that the toothpaste has an acidic effect on the dental caries.

Applicant has developed a film type tooth whitening agent in the Republic of Korea Patent No. 10-0403699 and succeeded in stabilization of the peroxide, it was applied to the toothpaste formulation to reach the present invention.

An object of the present invention is to provide a toothpaste by improving the tooth whitening performance of toothpaste while stabilizing peroxide effective in tooth whitening and introducing it into toothpaste, while toothpaste does not show acidity and is beneficial to dental health.

Toothpaste composition of the present invention for achieving the above object is characterized in that it comprises a peroxide layer containing a peroxide and a film composed of a support layer to protect the layer.

Here, it is preferable that a film is three or more layers, and a support layer was formed in both surfaces of a peroxide layer.

In the present invention, by preparing a film containing a peroxide in order to improve the stability of the peroxide, to minimize the contact between the peroxide and the toothpaste composition in the film to improve the stability of the peroxide. In particular, by including a peroxide-containing film on both sides of the peroxide-containing film in the toothpaste, the toothpaste can ensure the stability of the peroxide without showing acidity, which helps in dental health and whitening performance Can be improved.

The peroxide film included in the toothpaste composition of the present invention is basically similar in structure to the film used in the tooth whitening agent. Hereinafter, the structure of the peroxide film will be described in detail.

The peroxide film included in the toothpaste composition of the present invention is basically composed of a peroxide layer containing a peroxide and a support layer that prevents free movement of the peroxide on both sides thereof.

First, the main component of the peroxide layer should be a polymer that does not affect the stability of the peroxide. Polymers generally used include polyalkyl vinyl ether-maleic acid copolymers (PVM / MA copolymer; Gantrez AN 119, AN139, S97), polyvinyl alcohol, polyacrylic acid, polyethylene oxide (Polyox), polyvinylpyrrolidone-vinyl Acetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), polyvinylpyrrolidone (PVP; K-15 ~ K120), polyquaternium-11 (polyquaternium-11, Gafquat 755N), polyquater Nium-39 (polyquaternium-39, Merquat plus 3330), carboxypolymethylene (Carbomer, Carbopol), etc. are mentioned, These can be used individually or as a mixture. As the solvent of these polymers, water, ethanol alone or a mixture thereof can be used.

It is a polymer included in the product in order to improve spreading when brushing, including a hydrophilic polymer having good solubility in water. Carboxymethyl cellulose, Xanthan and the like can be used, and generally known hydrophilic polymers such as hydroxypropylmethyl cellulose, hydroxyethyl cellulose and flulan can be used. These can be used in the amount of 0.2-10 weight% in the range in which the peroxide safety is maintained.

The stability of peroxides used in teeth whitening or substances that can release peroxides from teeth is the most important factor in the efficacy of teeth whitening products, so their stability is important and stabilizers can be added for this purpose. . Commonly used peroxide stabilizers include alkylarylsulfonates, alkylsulfonate salts, alkylcarboxylate salts, alkyldiphenyloxide disulfonates, Span 20 (Sorbitan Monolaurate), and Span 40 (Sorbitan Monopalmitate). , Span 60 (Sorbitan Monostearate), Span 80 (Sorbitan Monooleate), Span 85 (Span 85, Sorbitan Trioleate), TWEEN (POE sorbitan fatty acid ester), Glycerin fatty acid ester, Organic monoglyceride Ride, sodium stearyl lactate, polysorbate (POE (20) Sorbitan Monolaurate, POE (20) Sorbitan Monostearate, POE (20) Sorbitan Monooleate, POE (20) Sorbitan Tristearate, POE (20) Sorbitan Trioleate) . Among these, 1 type or more can be mixed and used.

Peroxide is mentioned as a tooth whitening component added to a drug layer. Peroxides include hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, sodium perorate and tetrasodium pyrophosphate peroxidate and mixtures thereof It can select from the group which consists of these, and can use.

In the peroxide film included in the toothpaste composition of the present invention, a backing layer formed on both sides of the peroxide layer serves to protect the interior (peroxide layer) from physical and chemical contact with the toothpaste, and the shape of the product. Helps to keep To perform this function, it is preferable to use a water insoluble polymer or a polymer which is partially dissolved in water and easily decomposed by physical force for the release of peroxide when brushing the teeth. Available polymers include cellulose acetate phthalate, shellac, polyvinyl acetate, ethyl cellulose, poly methyl methacrylate, methacryloylethyl betaine / methacrylate copolymer (Yukaformer: Mitsubishi, methacryloylethyl betain / methacrylate copolymer), methacrylic acid copolymer (Methacrylic acid copolymer; Eudragit L 100, Eudragit L 12,5, Eudragit L 100-55, Eudragit L 30D-55), aminoalkyl methacrylate copolymer (Eudragit E 100, Eudragit E 12,5, Eudragit RL 100, Eudragit RL 30D), and the like, and these alone or in a mixture can be used.

It is possible to add various plasticizers to the backing layer of the peroxide film. In addition to propylene glycol, glycerin, and polyethylene glycol as plasticizers, various kinds of plasticizers may be used depending on the solvent used, and caster oil and hydrogenated caster oil may also be used.

Hereinafter, the present invention will be described in more detail with preferred embodiments of the present invention. However, these examples are only illustrative to aid the understanding of the present invention, and the scope of the present invention is not limited thereto.

EXAMPLE

Example  1 to 6, Comparative example  1 and 2

Toothpastes of Examples 1 to 6 and Comparative Examples 1 and 2 were prepared according to the composition and preparation method as described below. The same amount of peroxide was used to eliminate the error of the amount.

Production method: The support layer was applied on the release agent, the peroxide layer was applied, and then the support layer was applied again to prepare a film (the support layer was 5 to 30 µm and the peroxide layer was 50 to 200 µm). The prepared film was cut into a size of 0.3 mm x 0.3 mm and blended into the toothpaste so that the amount of peroxide in the total weight of the toothpaste was 0.75%. Toothpaste was prepared to contain 15% silica, 50% sorbitol, 15% water and binder, fluorine and phosphate.

Example  One

Drug layer preparation solution: 22 weight% of polyvinyl pyrrolidone, 5 weight% of hydrogen peroxide, 10 weight% of glycerin, 30 weight% of ethanol, 1 weight% of carboxymethyl cellulose, and 100 weight% was added to it.

Support layer preparation solution: 5 weight% of polyvinyl acetate, 5 weight% of glycerin, and ethanol were added, and it was 100 weight%.

Example  2

Drug layer preparation solution: 22 weight% of polyvinyl pyrrolidone, 5 weight% of hydrogen peroxide, 10 weight% of glycerin, 30 weight% of ethanol, 2 weight% of carboxymethyl cellulose, and 100 weight% of water were added.

Support layer preparation solution: 5 weight% of polyvinyl acetate, 5 weight% of glycerin, and ethanol were added, and it was 100 weight%.

Example  3

Drug layer preparation solution: 22 weight% of polyvinyl pyrrolidone, 5 weight% of hydrogen peroxide, 10 weight% of glycerin, 30 weight% of ethanol, 5 weight% of carboxymethyl cellulose, and 100 weight% of water were added.

Support layer preparation solution: 5 weight% of polyvinyl acetate, 5 weight% of glycerin, and ethanol were added, and it was 100 weight%.

Example  4

Drug layer preparation solution: 22 weight% of polyvinyl pyrrolidone, 5 weight% of hydrogen peroxide, 10 weight% of glycerol, 30 weight% of ethanol, 10 weight% of carboxymethyl cellulose, and 100 weight% were added.

Support layer preparation solution: 5 weight% of polyvinyl acetate, 5 weight% of glycerin, and ethanol were added, and it was 100 weight%.

Example  5

Drug layer preparation solution: 22 weight% polyvinyl pyrrolidone, 5 weight% hydrogen peroxide, 10 weight% glycerin, 30 weight% ethanol, 1 weight% xanthan, and 100 weight% was added water.

Support layer preparation solution: 5 weight% of polyvinyl acetate, 5 weight% of glycerin, and ethanol were added, and it was 100 weight%.

Example  6

Drug layer preparation solution: 22 weight% of polyvinyl pyrrolidone, 5 weight% of hydrogen peroxide, 10 weight% of glycerin, 30 weight% of ethanol, 5 weight% of xanthan, and water were added and it was 100 weight%.

Support layer preparation solution: 5 weight% of polyvinyl acetate, 5 weight% of glycerin, and ethanol were added, and it was 100 weight%.

Comparative example  One

Drug layer preparation solution: 22 weight% of polyvinyl pyrrolidone, 5 weight% of hydrogen peroxide, 10 weight% of glycerin, 30 weight% of ethanol, 1 weight% of carboxymethyl cellulose, and 100 weight% was added to it.

Here, only the drug layer was prepared without a support layer.

Comparative example  2

Drug layer preparation solution: 22 weight% of polyvinyl pyrrolidone, 5 weight% of hydrogen peroxide, 10 weight% of glycerin, 30 weight% of ethanol, 1 weight% of carboxymethyl cellulose, and 100 weight% was added to it.

Support layer preparation solution: 5 weight% of polyvinyl acetate, 5 weight% of glycerin, and ethanol were added, and it was 100 weight%.

Here, the support layer was produced only on one side of the peroxide layer.

Experimental Example  1: stability of peroxide

The stability of the peroxide in the toothpaste was measured as follows.

Peroxide Evaluation Method: Each flask was taken with a mixed solvent capable of dissolving all layers of the patch, and the appropriate amount of toothpaste was accurately weighed and completely dissolved. About 5 ml of 6 N hydrochloric acid was added thereto, and about 2 g of potassium iodide was dissolved in the dark place for 1 hour, and then titrated with 50 mM sodium thiosulfate solution to quantify the peroxide content in the toothpaste. Here, the storage temperature was 40 ° C., the humidity was 75% constant temperature and humidity, and evaluated after 4 weeks of storage in an aluminum laminated tube.

Table 1 below shows the amount of peroxide quantified in each toothpaste.

division Peroxide Remaining Remarks Example 1 94 Average value (five experiments each) Example 2 92 Average value (five experiments each) Example 3 98 Average value (five experiments each) Example 4 93 Average value (five experiments each) Example 5 93 Average value (five experiments each) Example 6 95 Average value (five experiments each) Comparative Example 1 65 Average value (five experiments each) Comparative Example 2 80 Average value (five experiments each)

As shown in Table 1 above, the peroxide in the toothpaste prepared in Example was more stable than the comparative example. Therefore, it was confirmed that the portion where the peroxide is in contact with the dentifrice composition is minimized by the impermeable film on both sides, so that the peroxide can exist in a stable state.

Experimental Example  2: whitening effect

The whitening effect of toothpaste was measured as follows.

(1) Preparation of Contaminated Specimens

The tablets of hydroxyapatite powder were made by IR press and sintered at 1000 ° C, then molded with epoxy resin to make resin, and the surface was etched with strong acid. The process of soaking and drying the specimens was repeated and this operation continued for one week to contaminate the specimens. The contaminated specimens were washed lightly with a toothbrush in running water to remove any contaminants that were easily dissolved or removed by water, and then dried at room temperature.

(2) Evaluation of whitening effect

Measure the brightness of the contaminated specimen and indicate it as L value, apply the peroxide-containing toothpaste prepared in Examples and Comparative Examples on a toothbrush, brush the specimen for 3 minutes using a machine, and then wash 200 times (day Corresponds to about 2 months as a standard 3) and then dried to measure the L value, and the change from the initial value was recorded.

The following Table 2 shows the amount of change of L value, that is, the amount of whitening change in the toothpaste prepared in Examples and Comparative Examples. The larger the change in L value, the better the effect.

division Whitening change Remarks Example 1 35 Average value (10 experiments each) Example 2 34 Average value (10 experiments each) Example 3 38 Average value (10 experiments each) Example 4 36 Average value (10 experiments each) Example 5 33 Average value (10 experiments each) Example 6 37 Average value (10 experiments each) Comparative Example 1 34 Average value (10 experiments each) Comparative Example 2 35 Average value (10 experiments each)

As shown in Table 2 above, in terms of the whitening effect, there was no difference between the toothpaste including the film on which the support layer was formed on both sides of the peroxide layer, and the toothpaste including the film formed on only one side or without the support layer. This can be seen as a toothpaste comprising a film having a support layer formed on both sides of the peroxide layer, while the peroxide is stabilized, but releases a sufficient peroxide when brushing to exert a whitening effect.

As described above, the toothpaste composition according to the present invention improves the stability of the peroxide by minimizing contact between the peroxide and the toothpaste composition by preparing a film containing the peroxide and including the same in the toothpaste, and the toothpaste does not exhibit acidic peroxide. It is possible to secure the stability of the toothpaste to improve the teeth whitening performance while helping the dental health.

Claims (8)

A dentifrice composition comprising a peroxide layer containing a peroxide and a film composed of a support layer protecting the layer. The dentifrice composition of Claim 1 in which a film is three or more layers. The dentifrice composition according to claim 1, wherein the support layer is formed on both sides of the peroxide layer. The method of claim 1, wherein the peroxides are hydrogen peroxide, carbamide peroxide, calcium peroxide, sodium percarbonate, sodium perborate, and sodium pyrophosphate. Toothpaste composition, characterized in that at least one member selected from the group consisting of peroxidate. The method of claim 1, wherein the peroxide layer is a polymer material to stabilize the peroxide, polyalkyl vinyl ether-maleic acid copolymer (PVM / MA copolymer), polyvinyl alcohol, polyacrylic acid, polyethylene oxide (Polyox), polyvinylpyrrolidone- Vinyl acetate copolymer (PVP / VA copolymer) with polyvinylpyrrolidone (PVP), polyquaternium-11, polyquaternium-39 and carboxypolymethylene (Carbomer, Carbopol) Toothpaste composition characterized in that it comprises one or more selected from the group consisting of. The method of claim 1, wherein the polymer material used for the support layer is cellulose acetate phthalate, shellac, polyvinyl acetate, ethyl cellulose, poly methyl methacrylate, methacryloylethyl betaine / methacrylate copolymer (methacryloylethyl Toothpaste composition characterized in that it comprises one or more selected from the group consisting of betain / methacrylate copolymer, methacrylic acid copolymer, and aminoalkyl methacrylate copolymer. The dentifrice composition of Claim 1 whose thickness of a peroxide layer is 50-200 micrometers. The dentifrice composition of Claim 1 whose thickness of a support layer is 5-30 micrometers.