KR20080106177A - Mixture of indoxacarb and dimehypo - Google Patents

Abstract

Disclosed is a mixture for protecting a plant from an insect pest comprising indoxacarb and dimehypo, and a method of its use for controlling the insect pest in an agronomic environment. ® KIPO & WIPO 2009

Description

Mixture of Indoxacarb and Dimehippo {MIXTURE OF INDOXACARB AND DIMEHYPO}

The present invention relates to a mixture comprising indoxacarb and dimehippo for protecting plants from insect pests, and to methods of use thereof for controlling insect pests in an agricultural environment.

There is a need in the agricultural industry for pesticide applications that can be applied in as low a dose as possible, are as harmful as possible to beneficial insects, and can be effective in controlling insect pest species with minimal disturbances in the environment. Insect pests are very destructive for crops and can result in significant losses in crop yield and quality, which leads to economic losses for growers and to increased costs for consumers. Typically, a combination of insecticides is used to broaden the range of insect control or to improve the control level of any given species by additive effect. Surprisingly, certain rare combinations provide agriculturally useful effects that surpass additive or synergistic effects.

Indoxacarb, Lepidoptera (e.g. cottonseed beetle, beetle beetle, fall beetle, cabbage and soybean beetle, codling moth and cabbage moth), Coleoptera (e.g. For example, many crops (eg, cotton, vegetables, and insects) from Colorado potato beetle and weevil) and Hemiptera (eg, cicada, plant bug, ligus bug) Commercially available from DuPont as an active ingredient in Avaunt ^® , Ammate ^® and Steward ^® insecticides for leaf applications to control insect pests of fruits). Indoxacarb acts particularly effectively and quickly on leaf-eating lepidoptera insects, but has little effect on beneficial insects (carnivorous insects and parasites) that are not herbivorous and only come in contact with indoxacarb as dry residue.

Dimehippo is marketed as an active ingredient in Pilarhope ^® , Helper ^® and Spontan ^® insecticides, and chews and licks many crops, including but not limited to rice, vegetables and fruit trees. Used to control insects that eat (especially Lepidoptera and Coleoptera). Dimehippo is an analog of neracetoxin and is generally considered to be a poison poison having both contact and systemic activity.

It is always desirable to be able to reduce the amount of chemical agent released to the environment while ensuring effective pest control. Although many combinations of pest control agents have been studied, synergism that increases agronomically useful efficacy is generally not seen. Synergy is described as "cooperative action of two components of the mixture such that the total effect is greater or longer than the sum of the effects of the two (or more) components independently obtained" (PML Yames, Neth. J. Plant Pathology 1964, 70, 73-80). Therefore, it is highly desirable to obtain pesticidal compositions that exhibit higher pest control efficacy than expected efficacy while simultaneously having reduced crop production costs and reduced environmental burden.

Mixtures of indoxacarb and dimehippo have been found in the present invention that provide surprisingly good insect pest control.

Summary of the Invention

The present invention provides indoxacarb (methyl (4aS) -7-chloro-2,5-dihydro-2-[[(methoxycarbonyl) [4- (trifluoromethoxy), useful for insect pest control. Phenyl] amino] carbonyl] indeno [1,2-e] [1,3,4] oxadiazine-4a (3H) -carboxylate) and dimehippo (also thiosulfato-sodium, and disodium) S, S '-[2- (dimethylamino) -1,3-propanediyl] ester thiosulfate).

The invention also includes a mixture of pesticide effective amounts of indoxacarb and dimehippo, and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents, and optionally further biologically active compounds or agents. It relates to an insecticidal composition.

The invention also relates to a method of protecting a plant from insect pests, comprising contacting the insect pest or environment thereof with a mixture comprising an insecticidal effective amount of indoxacarb and dimehippo.

“Comprise, include”, “comprising, including”, “have”, “having” or any other variation thereof is intended to include non-exclusive inclusion. For example, a composition, process, method, article, or device comprising a series of elements is not necessarily limited to these elements, and other elements that are not explicitly described or unique to such compositions, processes, methods, articles, or devices. Can include them. Also, unless expressly stated to the contrary, "or" means inclusive "or" and does not mean exclusive "or". For example, condition A or B is satisfied by any of the following: A is true (or present) and B is false (or not present), and A is false (or not present) ) B is true (or present), and both A and B are true (or present).

Also, in the English language, the indefinite articles "a" and "an" immediately before an element or component of the present invention are intended to be non-limiting with respect to the number of instances (ie, beings) of the element or component. Thus, "a" or "an" should be understood to include one or more than one, and the singular form of the element or component also includes the plural unless the number expressly means the singular.

In the context of the present disclosure, "insect pest control" means the inhibition (killing, reduced feeding and / or mating disturbances) of insect pest development, and the related expressions are similarly defined.

The term "agriculture" refers to the production of paddy field crops, such as for food and fiber, which includes corn, soybeans and other legumes, rice, cereals (eg, wheat, oats, barley, rye, rice, corn), Leafy vegetables (e.g. lettuce, cabbage and other rapeseed crops), fruit vegetables (e.g. tomatoes, peppers, eggplant, cruciferous and gourds), potatoes, sweet potatoes, grapes, cotton, fruit trees (e.g., Pomegranate, nucleus and citrus fruits), small fruits (berries, cherries) and other special crops (eg canola, sunflower, olives).

Embodiments of the invention as described in the "Summary of the Invention" include the following embodiments.

Embodiment 1. A mixture as described in the "Summary of Invention" wherein indoxacarb and dimehippo are present in a weight ratio of about 1: 1 to about 1:50.

Embodiment 1A. The mixture of embodiment 1, wherein indoxacarb and dimehippo are present in a weight ratio of about 1: 2.5 to about 1:40.

Embodiment 1B. The mixture of embodiment 1, wherein indoxacarb and dimehippo are present in a weight ratio of about 1: 5 to about 1:30.

Embodiment 1C. The mixture of embodiment 1, wherein indoxacarb and dimehippo are present in a weight ratio of about 1:15 to about 1:25.

Embodiment 2. The method as described in the "Summary of the Invention", wherein indoxacarb and dimehippo are applied successively.

Embodiment 2A. The method of embodiment 2, wherein indoxacarb is applied first, followed by dimehippo.

Embodiment 2B. The method of embodiment 2, wherein dimehippo is applied first, followed by indoxacarb.

Embodiment 2C. A method as described in “Summary of Invention”, wherein indoxacarb and dimehippo are applied simultaneously.

Embodiment 3. A method as described in "Summary of Invention", wherein the insect pest is a species of Lepidoptera.

Embodiment 3A. Insect pests are selected from one of the species: Creambidae, Gelechiidae, Noctuidae, Plutellidae, Pyralidae, and Tortricidae. The method of embodiment 3, wherein.

Embodiment 3B. This insect pest Resistencia Carly Booth Saginaw selruseu (Crambus caliginosellus), Resistencia Booth Luce Te Terrell (Crambus the teterrellus), O Dia Tribe Saccharomyces Lal lease (Diatraea saccharalis ), Keiferia lycopersicella , Pectinophora gossypiella ), Earias Insulara ( Earias insulana ), Earias vitella ( Earias) vittella ), Helicoverpa Armigera armigera ), Helicoverpa zea ), Heliotis bilessenz ( Heliothis virescens ), Spodoptera exigua ), Spodoptera frugiperda ) Spodoptera litura , Plutella xylostella), fill and be pre-buy-less (Chilo suppressalis), fills Cri Versus Poly (Chilo polychrysus ), Cnaphalocrocis Day medinalis), Maras Mia lease part (Marasmia patnalis ), sciropophaga incertulas ), sciropophaga innotata ), Sesamia inferens inferens), are kipseu are giroseu Pilar (Archips argyrospila ), Archips rosanas rosana ), Cydia pomonella ( Cydia pomonella ), species of Grapholita molesta , Leucinodes species, Maruca species, Ostrinia species, Trichoplusia species and Earias The method of embodiment 3, wherein the method is selected from species.

 Embodiment 3C. Insect pests are selected from the species of Siropopa insertulas, Siropopa innotata, Sesameia inferenz, Chilo Supresalis, Chilo Polycryus, Napallocsis Medialis and Marasmia Patnalis. The method of embodiment 3, wherein

Embodiment 3D. The method of embodiment 3, wherein the insect pest is sirophora inserthulas.

Embodiment 3E. The method of embodiment 3, wherein the insect pest is Silopopa is Innotita.

Embodiment 3F. The method of embodiment 3, wherein the insect pest is Sesameia inferens.

Embodiment 3G. The method of embodiment 3, wherein the insect pest is Chilo supresalis.

Embodiment 3H. The method of embodiment 3, wherein the insect pest is Chilo Polycryssus.

Embodiment 3I. The method of embodiment 3, wherein the insect pest is napallocsis mediallis.

Embodiment 3K. The method of embodiment 3, wherein the insect pest is Marasmia patalilis.

Embodiment 4. A method as described in "Summary of the Invention", wherein the insect pest is a species of stiletto.

Embodiment 4A. Insect pests include Cercopidae, Fleidae, Fulgoridae, Miriidae, Adelgidae, Aleyrodidae, Aphididae, Cicadellidae and The method of embodiment 4, wherein the method is selected from the species of one of Delphacidae.

Embodiment 4B. Insect pests of Yuri Aulax carnipex ( Euryaulax) carnifex ), Colgar Ferracutum peracutum ), Phromnia Rosea ), Fulgora Lanteraria ( Fulgora) lanternaria ), Lygus lineolaris), the teeth (Adelges in Adelaide Guess father abietis ), Bemisia argentifolii , Bemisia Tabashi tabaci ), Aphis species, Myzus persicae ), Nephotettix nigropictus ), Laodelphax striatellus ), Nilaparvata lugens ), Sogatella furcifera ), Sogatodes originalola ( Sogatodes) oryzicola ) and Recilia dorsalis .

Embodiment 5 The method as described in the "Summary of the Invention", wherein the insect pest is a species of Thysanoptera.

Embodiment 5A. The method of embodiment 5, wherein the insect pest is a species of Thripidae.

Embodiment 5B. The method of embodiment 5, wherein the insect pest is Frankliniella species.

Embodiment 6. A method as described in the "Summary of the Invention", wherein the plant belongs to one of the Brassicaceae, the Fabaceae, the Liliaceae, and the Poaceae.

Embodiment 7. The method of embodiment 6, wherein the plant belongs to the cruciferaceae.

Embodiment 7A. The method of embodiment 7, wherein the plant is Brassica species.

Embodiment 7B. Plants are Brassica carinata carinata), Brassica Ole La Seah (Brassica oleracea ), Brassica juncea , Brassica nigra ) Brassica napus napus ) or brassica rapa ( Brassica) rapa ). The method of embodiment 7.

Embodiment 8. The method of embodiment 6, wherein the plant belongs to the legume.

Embodiment 8A. The method of embodiment 8, wherein the plant is selected from species of the genus Phaseolus and Vigna .

Embodiment 8B. Pace plants come loose vulgaris (Phaseolus vulgaris ), Phaseolus coccineus), Pace come loose tea poly-house Aku (Phaseolus acutifolius), Pace come loose tooth Luna (Phaseolus lunatus ), Vigna angularis ), Vigna radiata ) or Vigna unguiculata ).

Embodiment 9. The method of embodiment 6, wherein the plant belongs to the family Liliaceae.

Embodiment 9A. Allium plant (Allium) species, the method of the embodiment 9.

Embodiment 9B. Plant Allium Ascalonicum ( Allium) ascalonicum ), Allium Sepa ( Allium) cepa ), Allium pistolum ( Allium fistulosum), Allium cancer Tupelo Pradesh breath variants Forum (Allium ampeloprasum var. porrum), Allium sativa boom (Allium sativum ) or allium schoenoprasum .

Embodiment 10. The method of embodiment 6, wherein the plant belongs to the pollen family.

Embodiment 10A. The method of embodiment 10, wherein the plant is an Oryza species.

Embodiment 10B. The method of embodiment 10, wherein the plant is Oryza sativa or Oryza glaberrima .

As an embodiment, a pesticidal effective amount of a mixture of Embodiments 1, 1A, 1B and 1C, and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents, and optionally further biologically active compounds or agents Of note is a pesticidal composition of the invention comprising.

Embodiments of the invention, including the embodiments 1-10B above as well as any other embodiments described herein, relate to compositions, mixtures, and methods of the invention that can be combined in any manner.

Examples of combinations of embodiments 1-10B include the following embodiments.

Embodiment A. The plants are brassica carinata, brassica oleracea, brassica Juncea, brassica nigra, brassica napus, brassica rapa, paseolus vulgaris, paseolus cosinus, paseolus Acutifolius, Paseolus Lunatus, Vigna Angoularis, Vigna Radiata, Vigna Unguikulata, Allium Ascalonicum, Allium Sepa, Allium Pistolsum, Allium Amfelpraprassum variants, A method as described in "Summary of Inventions", which is Allium Sativab, Allium Shoenoprassum, Oriza Sativa or Oriza Glaberimama.

Embodiment B. The method of embodiment A, wherein the plant is oryza sativa or oryja glaberima species.

It is found in the present invention that the application of indoxacarb and dimehippo not only protects the plant from certain leaf insects, but also provides control that substantially and surprisingly surpasses the expected simple additive effects of indoxacarb and dimehippo. lost.

Indoxacarb (CA (Chemical Abstracts) designation: methyl (S) -7-chloro-2,5-dihydro-2-[[(methoxycarbonyl) [4- (trifluoromethoxy) phenyl] amino ] Carbonyl] indeno [1,2-e] [1,3,4] oxadiazine-4a (3H) -carboxylate) has a molecular formula represented by the following formula (I).

Indoxacarb is most conveniently purchased as a commercial item, but can be prepared as described in US Pat. Nos. 5,462,938 and 5,869,657.

Dimehippo (CA name: disodium 2-dimethylaminopropane-1,3-bisthiosulfonate, also known as thiosulfato-sodium) has the molecular formula represented by the following formula (II), which is most conveniently purchased as a commercially available product: do.

Formulation / Utility

Mixtures of indoxacarb and dimehippo according to the invention can generally be used in preparations or compositions with agriculturally suitable carriers comprising at least one of a liquid diluent, a solid diluent or a surfactant. The mixture of indoxacarb and dimehippo may be formulated in two ways:

1. Indoxacarb and Dimehippo may be formulated separately and applied simultaneously or separately, for example by tank mixing, in an appropriate weight ratio; or

2. Indoxacarb and Dimehippo may be formulated together in a weight ratio as defined herein.

Thus, an agriculturally suitable carrier comprising an insecticidal effective amount of indoxacarb and one or more of a surfactant, a solid or liquid diluent; Agriculturally suitable carriers comprising pesticidally effective amounts of dimethipo and one or more of a surfactant, solid or liquid diluent; Or compositions comprising a pesticidal effective amount of a mixture of indoxacarb and dimehippo and an agriculturally suitable carrier comprising at least one of a surfactant, a solid or liquid diluent, are useful in the formulation of the present invention. Any or additional biologically active compound or agent in the composition of the present invention is before or after mixing with an indoxacarb and / or dimehippo with an agriculturally suitable carrier comprising at least one of a surfactant, a solid or a liquid diluent. It can also be combined.

Agriculturally suitable carriers are selected to match the physical properties of the active ingredient, the mode of application and environmental factors such as soil type, humidity and temperature. Useful formulations of indoxacarb and dimehippo may be prepared in a conventional manner, separately or together, or in combination with any additional biological compound or agent. Useful formulations include liquids, such as solutions (including emulsifiable concentrates), which may optionally be thickened into gels, suspensions, emulsions (microemulsions and / or suspending agents) and the like. Useful formulations also include dusts, powders, granules, pellets, tablets, films, and the like, which may be solid, such as water dispersible (“wettable”) or water soluble. The active ingredient (s) may be (micro) encapsulated and may also be formed as a suspension or solid preparation; Alternatively, the entire formulation of active ingredient can be encapsulated (or "overcoated"). Encapsulation can control or delay the release of the active ingredient (s). Sprayable formulations can be extended in a suitable medium and used in a spray volume of about 1 to several hundred liters per hectare. High concentration compositions are mainly used as intermediates for further formulation.

The formulations typically contain an effective amount of the active ingredient (s), diluents and surfactants in the following approximate ranges, the sum of which is 100% by weight.

Typical solid diluents are described in Watkins, et al. Handbook of Insecticide Dust Diluents and Carriers, 2nd Ed., Dorland Books, Caldwell, New Jersey. Typical liquid diluents are described in Marsden, Solvents Guide, 2nd Ed., Interscience, New York, 1950. McCutcheon's Detergents and Emulsifiers Annual, Allured Publ. Corp., Ridgewood, New Jersey, and also in Sisely and Wood, Encyclopedia of Surface Active Agents, Chemical Publ. Co., Inc., New York, 1964, lists surfactants and recommended usage. All formulations may contain small amounts of additives to reduce foaming, caking, corrosion, microbial growth, and the like, or thickeners to increase viscosity.

Surfactants include, for example, polyethoxylated alcohols, polyethoxylated alkylphenols, polyethoxylated sorbitan fatty acid esters, dialkyl sulfosuccinates, alkyl sulfates, alkylbenzene sulfonates, organosilicones, N, N-dialkyltaurates, lignin sulfonates, naphthalene sulfonate formaldehyde condensates, polycarboxylates, glycerol esters, polyoxyethylene / polyoxypropylene block copolymers, and alkylpolyglycosides, wherein the degree of polymerization (DP) The number of glucose units referred to as can range from 1 to 3, and the alkyl unit can range from C ₆ to C ₁₄ ) (see Pure and Applied Chemistry 72, 1255-1264). Solid diluents include, for example, clays such as bentonite, montmorillonite, attapulgite and kaolin, starch, sugars, silica, talc, diatomaceous earth, urea, calcium carbonate, sodium carbonate and sodium bicarbonate and sodium sulfate. Liquid diluents are, for example, water, N, N-dimethylformamide, dimethyl sulfoxide, N-alkylpyrrolidone, ethylene glycol, polypropylene glycol, propylene carbonate, dibasic esters, paraffins, alkylbenzenes, Alkylnaphthalene, glycerin, triacetin, olive oil, castor oil, linseed oil, tung oil, sesame oil, corn oil, peanut oil, cottonseed oil, soybean oil, rapeseed oil and coconut oil, fatty acid esters, ketones such as cyclohexanone, 2- Heptanone, isophorone and 4-hydroxy-4-methyl-2-pentanone, acetates such as hexyl acetate, heptyl acetate and octyl acetate, and alcohols such as methanol, cyclohexanol, decanol, benzyl and tetrahydrofur Contains furyl alcohol.

Useful formulations of the present invention may contain substances known to those skilled in the art as formulation aids such as antifoams, film formers and dyes. Defoamers, also can include water dispersible liquids comprising polyorganosiloxanes such as the stop at (Rhodorsil) ^® 416. Film formers may include polyvinyl acetate, polyvinyl acetate copolymers, polyvinylpyrrolidone-vinyl acetate copolymers, polyvinyl alcohol, polyvinyl alcohol copolymers, and waxes. Dyes, may include a water dispersible coloring material liquid composition, such as a Jed Take the (Pro-lzed) ^® Red colorant. Those skilled in the art will appreciate that this is a non-limiting list of formulation aids. Examples of suitable formulation aids include those listed herein and those listed in McCutcheon's 2005, Volume 2: Functional Materials published by MC Publishing Company and PCT Publication No. WO 03/024222.

Solutions comprising emulsifiable concentrates can be prepared by simply mixing the components. Dusts and powders can be prepared by blending and grinding, typically using a hammer mill or a fluid-energy mill. Suspensions are typically prepared by wet-milling (see, eg, U.S. 3,060,084). Granules and pellets can be prepared by spraying the active material on preformed granular carriers, or by agglomeration techniques. Browning, "Agglomeration", Chemical Engineering, December 4, 1967, pp 147-48, Perry's Chemical Engineer's Handbook, 4th Ed., McGraw-Hill, New York, 1963, pages 8-57 and below; and See WO 91/13546. Pellets are U.S. It may be prepared as described in 4,172,714. Water dispersible and water soluble granules are described in U.S. 4,144,050, U.S. 3,920,442 and DE 3,246,493. Tablets are U.S. 5,180,587, U.S. 5,232,701 and U.S. It may be prepared as taught in 5,208,030. The film is GB 2,095,558 and U.S. It may be prepared as taught in 3,299,566.

For further information regarding the field of formulation, see T. S. Woods, "The Formulator's Toolbox-Product Forms for Modern Agriculture" in Pesticide Chemistry and Bioscience, The Food-Environment Challenge, T. Brooks and TR Roberts, Eds., Proceedings of the 9th International Congress on Pesticide Chemistry, The Royal Society of Chemistry, Cambridge, 1999, pp. 120-133. In addition, U.S. 3,235,361, column 6, line 16 to column 7, line 19 and Examples 10 to 41; U.S. Column 5, lines 43 to column 7, lines 62 and Examples 8, 12, 15, 39, 41, 52, 53, 58, 132, 138 to 140, 162 to 164, 166, 167 and 169 to 182 of 3,309,192; U.S. Column 3, lines 66 to 5, line 17 and Examples 1 to 4 of 2,891,855; Klingman, Weed Control as a Science, John Wiley and Sons, Inc., New York, 1961, pp 81-96; Hance et al, Weed Control Handbook, 8th Ed., Blackwell Scientific Publications, Oxford, 1989; And Developments in formulation technology, PJB Publications, Richmond, UK, 2000.

In the examples below, all percentages are by weight and all formulations are prepared in a conventional manner. For example, the formulation ingredients of Example E were mixed together as a syrup, the active ingredients were added, and the mixture was homogenized in the blender. The resulting slurry was then wet-milled to form a suspension concentrate.

Example  A

Wettable powder Indoxacarb 3.0% Dimehippo 60.0% Dodecylphenol Polyethylene Glycol Ether 2.0% Sodium ligninsulfonate 4.0% Sodium silicate aluminate 6.0% Montmorillonite (Fire) 25.0%

Example  B

Granules Indoxacarb One% Dimehippo 9% Attapulgite granules (low volatility, 0.71 / 0.30 mm; U.S.S. No. 25-50 sieve) 90.0%

Example  C

Extruded Pellet Indoxacarb 5.0% Dimehippo 20.0% Anhydrous sodium sulfate 10.0% Crude calcium ligninsulfonate 5.0% Sodium alkylnaphthalenesulfonate 1.0% Calcium / Magnesium Bentonite 59.0%

Example  D

Emulsifying Concentrate Indoxacarb 1.0% Dimehippo 20.0% Blend of Oil Soluble Sulfonate and Polyoxyethylene Ether 10.0% Isophorone 69.0%

Example  E

Suspension Concentrate Indoxacarb 1.0% Dimehippo 20.0% Polyethoxylated fatty alcohols 15.0% Esters Derivatives of Montan Wax 3.0% Calcium lignosulfonate 2.0% Polyethoxylated / Polypropoxylated Polyglycol Block Copolymers 1.0% Propylene glycol 6.4% Poly (dimethylsiloxane) 0.6% Antibacterial agents 0.1% water 50.9%

Mixtures and compositions of the present invention comprising indoxacarb and dimehippo may also contain one or more additional biologically active compounds or agents, such as insecticides, fungicides, nematicides, fungicides, aphids, signal chemicals, insect repellents In addition, it can be further mixed with attractants, pheromones, and feeding stimulants to form multicomponent insecticides that provide a much wider range of agricultural protection. Examples of such agricultural protective agents that may be formulated with the compounds of the present invention are insecticides such as abamectin, acetate, carbaryl, carbofuran, cartaf, chloranthraniliprolol (DPX-E2Y45), chlor Pyriphos, Chlorpyriphos-methyl, Cyfluthrin, Cipermethrin, Diazinon, Fipronil, Flubendiamide, Monoclotophosphate, Forate, Rotenone, and Neonicotinoids such as acetamiprid , Clothianidine, imidacloprid, tiacloprid and thiamethoxam; Fungicides such as azoxystrobin, benomil, kaftan, carbendazim, cymoxanyl, ciprodinyl, difenocazole, diconazole, diniconazol-M, edifeneforce, epoxyconazole, phenarimol, Fenbuconazole, fenpropormoff, fluazinam, fluquinconazole, flusilazole, flutolanyl, flutriafol, polpet, pocetyl-aluminum, furalacyl, hexaconazole, ipconazole, if Robbenfoss, Iprodione, Cresoxime-methyl, Mancozeb, Manev, Mepronyl, Metallaccil, Metconazole, Michaelrobutanyl, Oxadixyl, Penconazole, Probenazole, Prochloraz, Propico Nazol, pyriphenox, tebuconazole, tetraconazole, thibendazole, thiophenate-methyl, thiram, tricyclazole and triticazole, uniconazole; Nematicides such as aldoxicarb and phenamifos; Fungicides such as streptomycin; And entomopathogenic bacteria, such as Bacillus thuringiensis subspecies Bacillus thuringiensis subsp. aizawai ) , Bacillus thuringiensis subsp. kurstaki ), and the encapsulated delta-endotoxin of Bacillus thuringiensis (eg, Cellcap, MPV, MPVII); Entomopathogenic fungi such as green disease fungi; And to viruses, nucleoside polyhedra with baculovirus (NPV), for example, helicase, Kobe fail-fast Jea new nucleoside in polyhedra virus (HzNPV), Ana Grappa eight o'clock Blow (Anagrapha falcifera ) nucleopolyheadovirus (AfNPV); And entomopathogenic viruses, including granulopathic virus (GV), such as Sidiom pomonella granulopathy virus (CpGV). The weight ratio of the additional biologically active compound or agent to the mixture of the present invention is typically 200: 1 to 1: 200, preferably 50: 1 to 1:50, more preferably 10: 1 to 1:10.

Abamectin, Acetate, Acetamiprid, Carbofuran, Carthaf, Chloranthraniliprol, Chlorpyrifos, Clotianidine, Cyfluthrin, Cipermethrin, Diazinon, Fipronil, Flu A mixture of the present invention comprising indoxacarb and dimehippo further mixed with additional biologically active compounds selected from the group consisting of bendiamide, imidacloprid, monoclotophos, formate, tiacloprid and thiamethoxam This is especially noteworthy.

Of note is a mixture of the present invention comprising indoxacarb and dimehippo, which are further mixed with monoclotoforce. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with chlorpyriphos. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with imidacloprid. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with fipronil. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with carbofuran. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with diazinone. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with the kartap. Of note is a mixture of the invention comprising indoxacarb and dimehippo further mixed with a forate. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with cipermethrin. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with thiamethoxam. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with abamectin. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with cyflutrin. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with acetate. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with tiacloprid. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with acetamiprid. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with clotianidine. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with chlorantraniliprole. Of note is a mixture of the present invention comprising indoxacarb and dimehippo further mixed with flubendiamide.

General references for these agricultural protection agents (ie insecticides, fungicides, nematicides, acaricides, herbicides and biological agents) are described in The Pesticide Manual, 13th Edition, CDS Tomlin, Ed., British Crop Protection Council. a Farnham, Surrey, UK, 2003] and ^{[the Biopesticide Manual, 2 nd Edition} , LG Copping, Ed., British Crop Protection Council, Farnham, Surrey, UK, 2001].

In certain cases, combinations with other pesticides with similar control ranges but different modes of action are particularly advantageous in resistance management. Insect pests are controlled by applying a biologically effective amount of the mixture of the invention directly to the environment of the insect pest, including the site of infection, to the area to be protected, or to the pest to be controlled. Accordingly, the present invention is directed to contacting an insect pest or environment thereof with a composition of the invention comprising a biologically effective amount of the mixture of the invention or said mixture which may comprise an effective amount of one or more additional biologically active compounds or agents. It includes a method of controlling insect pests, including. Examples of suitable compositions comprising a mixture of the present invention and / or a mixture of the present invention and an effective amount of one or more biologically active compounds or agents include, but are not limited to, wherein the additional biologically active compound is the same granule or mixture of the present invention. Granule compositions present on granules and on granules separate from the granules. In addition, the indoxacarb and dimehippo may be present on separate granules, and any further biologically active compound may be present on one of the indoxacarb or dimehippo granules or on a third set of granules. . In addition, modifications of the above types of granules can be combined to provide mixtures and / or compositions of the invention.

Thus, in one embodiment, a composition of the invention is a mixture of two or more granules containing different amounts of indoxacarb, dimehippo and any other agricultural protective agent (ie, a biologically active compound or agent) as the active ingredient. It includes. For example, one set of granules may comprise indoxacarb, and a second set of granules may comprise dimehippo as the active ingredient. These granule mixtures may be in accordance with the general granule mixture disclosure of PCT Patent Application Publication No. WO 94/24861, or more preferably the teaching of homogeneous granule mixtures of US Pat. No. 6,022,552.

Preferred contact method is by spraying. One embodiment of the method of the present invention for controlling herbivorous insect pests is by applying to a plant a mixture comprising an effective amount of indoxacarb and dimehippo. In addition, compositions comprising separate indoxacarb and compositions comprising dimehippo may be combined (eg tank mixed) and applied simultaneously as a physical mixture prior to application. Alternatively, after applying the pesticidal composition containing the composition having only one of indoxacarb and dimehippo, the composition with the other of indoxacarb and dimehippo may be applied.

The application rate required for effective control (ie, "biologically effective amount") depends on the species of insect pest to be controlled, the life cycle of the pest, the stage of life, its size, place of residence, time of year, host crop or animal, feeding behavior, Depends on factors such as mating behavior, ambient humidity and temperature. Under typical circumstances, the application rate of total active ingredient of about 100 g / ha to 2000 g / ha is sufficient to control pests in agricultural ecosystems, but as little as 10 g / ha may be sufficient or as much as 4000 g / ha Amount may be required. Total active ingredient is defined as the total weight of the active ingredient. Typically the weight ratio of indoxacarb and dimehippo is about 1: 1 to 1:50, preferably about 1: 2.5 to 1:40, more preferably about 1: 5 to 1:30, most preferably About 1:15 to 1:25. The application rate of the inventive mixtures according to the process of the invention can be influenced by many factors in the environment, which must be determined under actual conditions of use. One skilled in the art can readily determine the biologically effective amount required for the desired insect pest control level.

For insect pest control scope and economic importance, it is an embodiment of the present invention to protect agricultural crops from damage or damage caused by insect pests.

The method of the present invention is a lepidoptera of the chestnut moth, such as giant beetle, macropods, beetle, and heliotine (e.g. Paul giant beetle [Spododotera pruperifera JE Smith], beet beetle beetle) [Spodogerra Exibua Huebner], Roundup Seminar Room [Agrotis Ypsilon]Agrotis ipsilon) Hufhagel], Cabbage Beetle [Tricofluciani (Trichoplusia ni) Huebner], tobacco moth [Heliotis birescens Fabricius]); Tree moths from the family of moths, casebearers that make protective cocoons, webworms, horn moths, cabbage worms and allan moths (e.g., European corn bark [Austrian Nubilealis)Ostrinia nubilalis) Huebner], Navel Orange Bug [Amiellois Transitella (Amyelois transitella) Walker]); Cobweb moths from the insect moth family (eg grass worms [Herpetogramma licarsisalis Walker], corn root cobweb moths [Crambus caliginoceles]Crambus caliginosellus) Clemens]); Leaf moths, eye bugs, seeds and fruit beetles (eg, Codling moth [Sidiom pomonaella Linnaeus], Grape berry moth [Endopizza viteaana])Endopiza viteana) Clemens], Peach Sprout Moth [Grapolita Molesta Busck]); And many other economically important Lepidoptera, such as the Chinese cabbage moth [Flutella xyllostella Linnaeus], the pink cottonseed beetle [Pectinophora gopipiella Saunders], the cicada moth [Lymantria dispar Linnaeus], Larvae and adults; Coleoptera including the weevil from Anthrabidae, Bruchidae and Curculionidae (e.g., cotton beetle weevil [Antonomos grandisAnthonomus grandis) Boheman], Rice weevil [Rithor Hoptrus Orizophilus (Lissorhoptrus oryzophilus) Kuschel], Grain Weevil [Sitophilus Granarius (Sitophilus granarius) Linnaeus], rice weevil [Sitophilus orizae (Sitophilus oryzae) Linnaeus], an annual weevil weevil [Ristonotous maculolis (Listronotus maculicollis) Dietz], Sapphusium weevil [Sphenophorus parbulus (Sphenophorus parvulus) Gyllenhal], Hunting Weevil (Spernophorus Venatus Vestitus)Sphenophorus venatus vestitus)), Denver weevil [Spernophorus Sicatritiatus (Sphenophorus cicatristriatus) Fahraeus]); Lepidoptera beetle, cucumber leaf beetle, root beetle, leaf beetle, potato leaf beetle and oyster moth of Chrysomelidae (eg, Colorado leaf beetleLeptinotarsa decemlineata) Say], Western Corn Root Beetle [Diabrotica Birgifera Birgifera (Diabrotica virgifera virgifera) LeConte]); Scarabs and other beetles from Scarabaeidae (eg Japanese beetles [Popilia japonica (Popillia japonica) Newman], Spotted Scarab [Anomaly Orientalis (Anomala orientalis) Waterhouse], Northern Mask Beetle [Cyclocepala Borealis (Cyclocephala borealisArrow], Southern Mask Beetle [Cyclocepala Imakulata (Cyclocephala immaculata) Olivier], Black Grass Atahenius [Atahenius Sputteruls (Ataenius spretulus) Haldeman], Oak Leaf ScarabCotinis nitida) Linnaeus], Asian Garden Scarab [Maladera Castanea (Maladera castaneaArrow], May / June Scarab (Pilopaga (PhyllophagaSpecies) and European beetles [resortrogus magalis (Rhizotrogus majalis) Razoumowsky]); Locust from Dermestidae; Worms from Elateridae; Useful for protecting plants from a wide range of insect pests, including eggs, leaf feeding, fruit feeding, root feeding, seed feeding, and bullous tissue feeding larvae and adults Do. In addition, agricultural pests include Dermaptera (for example, the European worm [forpicula aurularia), including the worm from Forficulidae.Forficula auricularia) Linnaeus], Black Nipper [Cheliosoches Morio (Chelisoches morio) Fabricius]) eggs, adults and larvae; Stink wood and Homoptera, such as B sting from Blind stink bug, Cicada from Cicadidae, Cicada from Cicada family (eg Empoasca (EmpoascaSpecies), extinct from the Faerie beetle family (for example citrus extinct [Colgar Ferracutum Walker], mango extinct (Colloriides acuminate)Colgarorides acuminate) Walker), plated leaf beetle [Promonia tree Isalo] and green extinct [Siphanta acuta Walker]), Fulgoroidae (e.g. (Fulgora Lanternaria), Peanut Worm (Lanternaria Lanteraria)Lanternaria lanternaria)) And Anniaceae, Antlers from Membracidae, Trees from Psyllidae, Powders from Powderyaceae, Aphids from Aphids, Root-beetles from Phylloxeridae, Pseudococcidae Beetles from Coccidae, Diiaspididae and Margarodidae from Margarodidae, Shield bugs from Tingidae, Stink bugs from Pentatomidae, Bed bugs For example, hairy bedbug worms [Blisus reucoccterus hyrtus (Blissus leucopterus hirtus) Montandon] and Southern Bedbug Beetle [Blisus Insularis]Blissus insularis) Barber]) and other seed worms from Lygaeidae, foam worms from the frothyaceae family (eg foam worms [Sercopis sanguinea (Cercopis sanguinea) Geoffroy, [Sercopis Bullerata (Cercopis vulnerata) Rossi]) and sugar cane worms [Eurasian ulrox carnipex Fabricius], amber stink bug from Coreidae, and stink bug sting and Pyrrhocoridae eggs, immature, adult And larvae. In addition, Orthoptera (including, for example, larvae, grasshoppers and crickets) (e.g.Melanoplus sanguinipes) Fabricius] and [Melanoplus Diferentialis (M. differentialis) Thomas]), US Wikipedia (e.g. [Schistoserca Americana (Schistocerca americana) Drury]), Desert Locust [Schistoserca Gregaria (Schistocerca gregaria) Forskal], Mobile Grasshopper [Rocusta Migrattoria (Locusta migratoria) Linnaeus, Shrub Grasshopper (Zonoserus)Zonocerus) Species)), House Cricket [Acheta Domesutikkusu (Acheta domesticus) Linnaeus], the ground puppy (for example, the tan puppy [Scapteriscus vicinus (Scapteriscus vicinus) Scudder] and Southern Puppy [Scapteriscus BorelliiScapteriscus borellii) Giglio-Tos]) eggs, adults and immatures; Leaf oyster flies, on the back, fruit flies (Tephritidae), frit flies (eg, [Osinella frit (Oscinella frit) Linnaeus]), soil maggots, housefly (for example, [Musca Domestica (Musca domestica) Linnaeus]), baby house flies (eg [Pania Canicularis (Fannia canicularis) Linnaeus, [Pania Femoralis (F. femoralis) Stein]), chimpanzees (eg [Stormxis calcitance (Stomoxys calcitrans) Linnaeus]), face flies, horn flies, large black flies (eg, chrysomia)Chrysomya), Formia (Phormia), As well as other muscoid fly pests, horse flies (e.g., Tabanus)Tabanus) Species, horse flies (e.g., Gastrophilus (GastrophilusSpecies, Oestrus (OestrusSpecies), cowflies (e.g. Hippoderma (HypodermaSpecies), deer flies (e.g.Chrysops) Species, ked (eg [Melopagus obinus (Melophagus ovinus) Linnaeus]) and other Brachycera, mosquitoes (eg, Aedes)Aedes), Anopheles (Anopheles), Coolex (Culex) Species, black fly (e.g., prosiumum)ProsimuliumSpecies, siriumSimuliumSpecies), radish, etc., eggs, adults and immatures of sand flies, rhizome mites, and other Nematocera; Onion shovel [Trips Tabashi (Throps tabaciLindeman], flower shovel [Franclinella spp.] And other leaf feeding shovels, including eggs, immatures and adults of the coleoptera.

Mixtures of the present invention include Lepidoptera (e.g., [Chilo Polycryssus Meyrick] (Darkhead Paddy Wood), [Chilo Supresalis Walker] (Striped Paddy Wood), [Nappalocrosis Medialis Guenee] (Rice leaf moth), [Crambus Caliginoscelus Clemens] (corn root cobweb moth), [Diatraea sacaralis Fabricius] (sugarcane), [Diatraea crambidoides Grote] (Southern Corn) Bark), [Earias Insulana Boisduval] (thorny cottonseed beetle), [Earias Vitella Fabricius] (spot cottonseed beetle), [Helicoberpa Armigera Huebner] (American cottonseed beetle), Marasmia patnalis ( Perched Moth), [Australian Nubilalis Huebner] (European Corn Timber), [Pseudaletia unipuncta Haworth] (Coarse Insect), [Pectinophora Gapipiela Saunders] (Pink Cottonseed Beetle) Pieris Brassica ( Pieris brassicae ) Linnaeus] (big white butterfly), [Pierris rapae ( Pieris rapae ) (small white butterfly), [ Flutella xyllostella Linnaeus] (cabbage moth), [ Sirpophaga innotata] innotata ) (white-trunk), syrupopaga scirpophaga incertulas ) (Yellow Stem Tree Root ), Sesameia inferenz (Pink Stem Tree Root), [Spodoptera Exibua Huebner] (Sugar Beetle Beetle), [Spodoptera Litura ( Spodoptera) litura ) Fabricius] (tobacco castella , larvae), Spodoptera littoralis ) (leaf beetle), [Spodogerra prugiferda JE Smith] (Paul giant saltworm), [Tricoflucia ny Huebner] (cabbage beetle), Lucinodes species (e.g. eggplant bark), parquet It exhibits particularly high activity against pests of Kajong (bean pods), Austrian species (eg, European corn bark) and Tricoflucia spp. (Worms).

Mixtures of the present invention may also contain members from stinkwood and cicada , such as [ Acyrthosiphon] pisum ) Harris (pea aphids), Apis Krasivora ( Aphis) craccivora) Koch] (Eastern aphids), [Apis waves bar (Aphis fabae ) Scopoli] (black bean aphid), [ Aphis gossypii ) Glover] (cotton aphid, melon aphid), [ Auracorthum Solani ( Aulacorthum) solani )] Kaltenbach] (Digitalis aphid), [Mizu Persicae ( Myzus persicae Sulzer] (green peach aphid), [ Nasonovia ribisnigri Mosley] (lettuce aphids), Rhopalosiphum maidis ) Fitch] (corn leaf aphid), [ Rhopalosiphum padi ) Linnaeus] (bird cherry-oat aphid), [ Shizapis graminum ( Sizaphis) graminum ) Rondani] (green beetle), [ Sitobion avenae Fabricius] (British grain aphids); [Bemisia Tabashi Gennadius] (tobacco powder, sweet potato powder), [ Bemisia Argentipoli Bellows & Perring] (silver leaf powder), and [ trialeurodes vaporariorum] vaporariorum ) Westwood] (greenhouse flour ); [Empoasca fabae Harris] (potato cicada), [ Laodelphax striatellus] striatellus ) Fallen] ( Macrolestes Quiadillineatus) quadrilineatus ) Forbes ( Astral cicada ), Nephotettix cinticeps ) Uhler] (green cicada ), Nephotettix nigropictus ) Stal] (rice cicada ), [ Nilaparvata lugens ) Stal] (rice extinction), [ Peregrinus maidis Ashmead] (corn extinction), [Licilia Dorsalis Motschulsky] (zigzag cicada), [Sogatella pursiferra Horvath] (white light) Anchovy), Sogatodes Origco Muir (Delphacid), Icerya purchasi ) Maskell] (citrus beetle), [ Acrosternum hilare) Say] (pulsaek norinjae), [Ana Satri seutiseu (Anasa tristis De Geer] (Pumpkin), [ Blissus Recoterus Recotheterus ( Blissus) leucopterus leucopterus ) Say] (bedbug worm), [ Dysdercus suturellus ) Herrich-Schaeffer (cotton pest), [ Euchistus servus ) Say] (brown stink bug), [ Euchistus variolius ( Euchistus) variolarius ) Palisot de Beauvois (1-spot stink bug), Nezara viridula viridula ) Linnaeus] (southern green stink bug), [ Oebalus fuebalus pugnax Fabricius] (rice stink bug), [Yuriulax carnipex Fabricius] (sugarcane worms), and [Promonia tree Isalo] (plated leaf worms).

Mixtures of the present invention may also be used for the preparation of the coleopteran (eg, Frankliniella [ Frankliniella]). occidentalis ) Pergande (Western Flower Shovel, Insect Beetle), [ Sirtothrips] citri ) Moulton] (citrus shovel ), [ Sericothrips variabilis ) Beach] (soybean shovel), and [Trips Tabashi Lindeman] (onion shovel); And coleopteran (eg, [Cytophyllus oriza Linnaeus] (rice weevil)).

Fills (Chilo), sesame ah (Sesamia), Syr Popa is (Scirpophaga), trumpet in Croix Systems (Cnaphalocrocis) and Maras Mia (Marasmia) in the ipmalyi for the Lepidoptera pests such as (folder / roller) and rice stalks piece of wood over there.Sweet Of particular note are mixtures of the invention which exhibit high activity.

Of note is the use of the inventive mixtures for the control of US cottonseed worms [Helicoberpa Armigera Huebner]. Of note is the use of the mixtures of the present invention for the control of sugar beetle beetles [Spodoptera exigua Huebner]. Of note is the use of the mixtures of the present invention for the control of tobacco castorate [Spodogerra litura Fabricius]. Of note is the use of the mixtures of the present invention for the control of Chinese cabbage moth [Flutella xylostella Linnaeus]. Of note is the use of the mixtures of the present invention for the control of darkhead paddywood [Chilo Polycryssus Meyrick]. Of note is the use of the mixtures of the present invention for the control of striped rice bark [Chilo Supresalis Walker]. Of note is the use of the mixtures of the present invention for the control of rice leaf moth [napallocsis mediallis Guenee]. Of note is the use of the mixtures of the present invention for the control of rice leaf moth (Marrasmia patnalis). Of note is the use of the mixtures of the present invention for the control of white stem bark (Sirpopa innotata). Of note is the use of the inventive mixtures for the control of yellow stem bark (Sirpopa insertulas). Of note is the use of the mixtures of the present invention for the control of pink stem bark (Sesamia inferenz). Of note is the use of the mixtures of the present invention for the control of bark of Lucinodes, Maruca and Austrian species. Of note is the use of the mixtures of the present invention for controlling insects of Tricoflucia spp.

Owl Glass Rocks (Euryaulax), Cole taught (Colgar), prompting California (Phromnia) and loosen LA (Fulgora) in the leaf fleas and worms; And Adel GUESS (Adelges), bemi cyano (Bemisia), Apis (Aphis), America's (Myzus), four Forte ticks (Nephotettix), Rao del Pax (Laodelphax), Renilla Parr Vata (Nilaparvata), Soga telra (Sogatella ), small rabbits and the mixture of the present invention showing the des (Sogatodes) and resil Liao (Recilia) in the white flies, aphids and maemichung including particularly high activity against pests of Hemiptera and of Hemiptera is noted.

Of note is the use of the mixtures of the present invention for the control of sugar cane worms [Yuriulax carnipex Fabricius]. Of note is the use of the inventive mixtures for the control of the cottonseed larvae of the plated leaf worm [Promonia tree Isalo]. Of note is the use of the inventive mixtures for the control of silver leaf flour [Bemisia argentipoli Bellows & Perring]. Of note is the use of the inventive mixtures for the control of aphids (Apis species). Of note is the use of the inventive mixtures for the control of green pink aphids [Sulzer, Misso Persia]. Of note is the use of the inventive mixtures for the control of rice cicada larvae [Nepotetics nigropictus Stal]. Of note is the use of the mixtures of the present invention for the control of locusts (Lao delfax striatellus Fallen). Of note is the use of the mixtures of the present invention for the control of rice extinction [Nilaparvata Rugenz Stal]. Of note is the use of the inventive mixtures for the control of the white light extinction [Sogatella Pursiferra Horvath]. Of note is the use of the inventive mixtures for the control of rice delfaside [Sogatodes origola Muir]. Of note is the use of the inventive mixtures for the control of zigzag cicada larvae [Licilia Dorsalis Motschulsky].

The method of the present invention is useful for the protection of a wide range of plants that are vulnerable to leaf insect pests in an agricultural environment. Examples of a wide variety of plants that can be protected from insect pests by the methods of the present invention include, for example, the family of apples (eg, apple [malus fumila (Malus pumila) P. Mill.], Pear [Pyrus Communis (Pyrus communisL.]) and nucleus (eg, cherry (Prunus (Prunus) Species, such as [Prunus avium (P. avium) (L.) L.] and [Prunus cerasus (P. cerasus) L.]), apricot [Prunushum Armeniaca (Prunus armeniaca) L.], one way [Prunus dulcis (Prunus dulcis) (P. Mill) D. A. Webber], Peach [Prunus Persica (Prunus persica) (L.)], Peach [Prunus Persica (L.) Batsch var. Nushi Persica (nucipersicaSuckow C. Schneider, Prunus DomesticaPrunus domestica) L.]), including the Rosaceae, Rutaceae (ie, citrus fruits, such as orange [citrus sinensis (Citrus sinensis) (L.) Osbeck], Tangier Orange [Citrus Reticulata (C)itrus reticulata) Blanco, lemon [citrus limon (Citrus limon(L.) Burm. f.], lime [citrus aurantifolia (Citrus aurantifolia(Christmas) Swingle], paragraph [Citrus Maxima (Citrus maxima(Burm. F.) Merr.] And grapefruit (citrus maxima x sinelsis (Citrus maxima x sinensis), Sapindaceae (e.g., Longan [Dimocarpens Longan (Dimocarpns longan) Lour.]), Rambutan [Nepulium Lapaseum (Nephelium lappaceumL.], Pulasan [Neliumium Mutabile (Nephelium mutabile) Blume], Rich [Rich Kinensis (Litchi chinensisSonn.]), Anacardiaceae (eg mango [mangifera indica (Mangifera indicaL.]), Bombacaceae (e.g., durian [Durio Gibetinus (Durio zibethinus) L.]), Moraceae (e.g. Jackhurut (e.g., [Atocarpus heterophyllus (Artocarpus heterophyllus) Lam.]), And Myrtaceae (eg, rose apple [Sigium Zambos (Syzygium jambos(L.) Alston]) Fruit tree, such as the plant species. Also, examples include coffee (for example, [Copea Arabica (Coffea arabica) L.], Copea Canepora (Coffea canephoraRueaceae and cotton (e.g., [Gossipium hirsulum]Gossypium hirsulum) L.], [Gossipium Barbardense (Gossypium barbadense) L.]) shrubs of Malvaceae; Grapes (for example, Vitis lavrusca (Vitis labrusca) L.], [Vitis vinifera (Vitis viniferaVines of Vitaceae, such as) L.]); Lettuce [lactuka sativa (Lactuca sativa) L.], such as plants of the Asteraceae; Vegetable beets and sugar beet (both [beta vulgaris (Beta vulgaris) L.]), such as the plant of Chenopodiaceae; Cucumis (Cucumis), Kukurvita (Cucurbita) Species and Citrus (Citrullus) Species, such as cucumbers (eg, vegetable cucumbers [Cucumis sativas (Cucumis sativusL.]), pumpkins (for example, winter pumpkins [Cuccurvita maxima (Cucurbita maxima) Duchesne], Crew Neck Pumpkin [Kukukurvita Moscarta (Cucurbita moschataDuchesne ex Poir.], Pumpkin [Cucourvita Pepo (Cucurbita pepo) L.]) and melon (eg, cantaloupe and nectar [Cucumis melo (Cucumis melo) L.]), watermelon [Citrullus Ranatus (Citrullus lanatusThunb. Matsumura & Nakai], including plants of the Cucurbitaceae; Solarum (Solanum) And capsicum (Capsicum) Species, such as tomatoes [solumnum lycophericum (Solanum lycopersicum), Peppers and other vegetable peppers [capsicum annum (Capsicum annuum) L.], eggplant [solumnum melogena (Solanum melongena) L.] and Irish potato [solumnum tubersum (Solanum tuberosumL.], including plants of Solanaceae; Cabbage and Brussels sprouts of the Cruciferaceae (Brassicaceae or Cruciferaceae); Legumes (Fabaceae or Leguminosae) (eg, species of the genus of the genus); Lilies (eg, allium species) onions; Potted plants (eg rice (Orija sativa), corn [Zea maysZea maysL.], Sugar Cane [Sakarum Officinarum (Saccharum officinarum) L.]) are crops.

Of particular note is the method of the invention useful for protecting plants of the cruciferous, legume, liliaceae and pollen family. Brassicaceae, the Chinese kale (Brassica Al Vogel Lavra (Brassica alboglabra)), cabbage (Brassica Carry appear (Brassica carinata )), kale, cauliflower, broccoli and sprouted cabbage (all [Brassica oleracea L.]), Chinese cabbage [Brassica rapa subspecies chinensis], Chinese mustard or Indian mustard (Brassica Juncea or Brassica Kinen) system (Brassica chinensis )), black mustard (Brassica nigra), mustard, oilseed rape, canola and Brassica species, including Swedish turnips (Brassica napus) and turnips (Brassica rapa). Legumes are common beans (Paseolus vulgaris), pod beans (Paseolus cosinus), kidney beans (Paseolus acutifolius), lima beans (Paseolus lunatus), red beans ( Crops, including kidneys and eastern species, such as Vigna Anguillaris), mung beans (Bigna radiata) or black-eyed pea / bean (Bigna Unguikulata). Liliaceae, shallot (Allium Ascalonicum), Onion (Allium Sepa), Spring Onion (Allium Pistulumum), Leek (Allium Ampelophraum Variant Forum), Garlic (Allium Sativabum) and Chive (Allium Show) Crops such as enoprasum) and allium species. Pollen family includes crops such as arachnids such as rice ([Orija Sativa Linnaeus] and [Orija Glaberima Steud]).

Of note is the use of the inventive mixtures for the protection of Brassica Carinata, Brassica oleracea, Brassica Juncea, Brassica nigra, Brassica napus or Brassica rapa. Use of the mixtures of the present invention for the protection of Paseolus vulgaris, Paseolus cosinus, Paseolus acutifolius, Paseolus lunatus, vigna angularis, vigna radiata or vigna unguikulata This is noted. Of note is the use of the mixtures of the present invention for the protection of allium ascalonicum, allium cepha, allium pistolumum, allium ampeloprsum variant formum, allium sativabum or allium shoenoprasum. Of note is the use of the inventive mixtures for the protection of oryza sativa or oryza glaberima.

The marked synergism exhibited by the mixture of indoxacarb and dimehippo allows the application rate of one or both of these active ingredients to be substantially reduced while maintaining good pesticidal efficacy. An effect beyond the expected effect lasts for several days after application, which promotes rapid overthrow and killing. Reducing the application rate reduces the processing costs for farmers and also mitigates the environmental burden from both manufacturing waste and crop protection chemical residues.

The presence of synergistic effects between the two active ingredients can be established using the Colby equation (Colby, SR, "Calculating Synergistic and Antagonistic Responses of Herbicide Combinations", Weeds 1967, 15, 20-22). Reference)

Using Colby's method, the presence of synergistic interactions between two active ingredients is established by first calculating the activity estimate (p) of the mixture based on the activity of the two ingredients applied alone. In the above formula, A is the pesticidal activity as the control ratio (%) by one component applied alone at the ratio x. Item B is pesticidal activity as% control by the second component applied at the rate y. If the effects of A and B are exactly additive and no interaction occurs, the estimated pesticidal activity (p) of the mixture of A of ratio x and B of ratio y is calculated from the above equation. If the effect of the experimentally established mixture is greater than the expected activity (p), then a synergy is present. To use Colby's formula, the active ingredients of the mixture are applied separately and in combination in the test.

Biological of the Invention Example

The following tests demonstrate the efficacy of controlling the mixtures or compositions of the present invention against specific pests and provide experimental evidence for the synergistic action between indoxacarb and dimehippo. However, the insect control protection provided by the mixtures or compositions of the present invention is not limited to these species. Synergy or antagonism between the mixtures or compositions was determined using Colby's formula. If the percent control rate is higher than the expected percent control rate "p", the mixture or composition exhibits a synergistic effect. If the% Controlled value is equal to or less than the% Control expected, the mixture or composition only shows an additive or antagonistic effect.

Test A

To evaluate the control of yellow stem bark (Syrpopa insertulas), rice seedlings (2-3 weeks old) were transplanted into a plastic container 15 cm in diameter and 15 cm high filled with soil, and then placed outside under a shading cloth. Grown. One plastic container was considered as one repeat sample and four replicate samples were used in a randomized complete block design. At the start of the experiment, the test plants were in the 4-leaf growth stage.

Test compounds were obtained as a commercially available preparation, the Viper carbalkoxy is a suspension concentrate formulation cancer was the formate ^® SC (active component 15%), dimethoxy Hippo is a wettable powder formulation spawned carbon ^® WP (50% active Ingredients). The test compound was dissolved in water, tank mixed according to a specific test rate, and sprayed using a CO ₂ -assisted backpack sprayer equipped with a hollow-cone nozzle to deliver 400 liters per hectare over the top of the rice plant. One day after spraying the test plants, yellow stem bark neoplasms (newly hatched larvae) were artificially infected at a rate of 20 neoplasms per rice hill.

Rice plants were visually evaluated 6, 11 and 14 days after spraying rice plants with test compounds to count plants showing signs of dead heart by yellow stem bark feeding. The data were then converted to percent lethal control.

The test results are shown in Table A below.

Table A shows that the mixtures and compositions of the present invention show the control of yellow stem bark (Sirpopa insertulas), with some having a significant synergistic effect. Since the percent mortality rate cannot exceed 100%, an unexpected increase in percent mortality rate can be maximized only when a separate single active ingredient is applied at an application rate that provides much less than 100% control rate. have. If the individual sole active ingredients have low activity, no synergy may be apparent at low application rates. However, in some cases, high activity was seen in the combination even when the individual alone active ingredients applied at the same application rate were essentially inactive. The synergy was indeed very remarkable. The most consistent strong synergy was seen when indoxacarb was applied at greater than 7.5 g / ha (eg 15 or 30 g / ha). It is noteworthy that the weight ratio of indoxacarb to dimehippo in the mixtures and compositions of the present invention ranges from 1: 2.5 to 1:20.

Accordingly, the present invention provides improved compositions as well as methods of use thereof for controlling insect pests in agricultural environments. The composition of the present invention shows a high control effect against insect pests, and consequently, by using it as a pesticide, the production cost and environmental burden of crops can be reduced.

Claims (12)

A mixture comprising indoxacarb and dimehippo. The mixture of claim 1 wherein indoxacarb and dimehippo are present in a weight ratio of about 1: 1 to about 1:50. The mixture of claim 2 wherein the indoxacarb and dimehippo are present in a weight ratio of about 1: 5 to about 1:30. A pesticidal effective amount of the mixture of claim 1 and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents, and optionally further biologically active compounds or agents, for protecting plants from insect pests. Composition. A method of protecting a plant from insect pests comprising contacting the insect pests or their environment with a biologically effective amount of the mixture of claim 1. The method of claim 5, wherein indoxacarb and dimehippo are applied simultaneously. The method of claim 5, wherein the insect pest is a species of Lepidoptera. 8. The insect pest of claim 7, wherein the insect pest is Siropopha in Scuterophaga incertulas, Siropopa in Scotapophaga innotata ), Sesamia inferens inferens ) Chilo Supresalis ( Chilo suppressalis ), Chilo Polycress ( Chilo polychrysus ), Cnaphalocrocis medinalis ) and Marasmia patnalis . The method of claim 8, wherein the insect pest is siropopa insertulas. The method of claim 5 wherein the plant is a species selected from one of Brassicaceae, Fabaceae, Liliaceae and Poaceae. The plant of claim 10, wherein the plant is Brassica carinata. carinata), Brassica Ole La Seah (Brassica oleracea ), Brassica juncea , Brassica nigra ) Brassica napus napus ) or brassica rapa ( Brassica) rapa ), Phaseolus vulgaris ), Phaseolus coccineus ), Phaseolus acutifolius ), Paseolus lunatus ( Phaseolus) lunatus ), Vigna angularis ), Vigna radiata ), Vigna unguiculata ), Allium Ascalonicum ( Allium) ascalonicum ), Allium Sepa ( Allium) cepa ), Allium pistolum ( Allium fistulosum ), Allium ampeloprasum var. porrum), Allium sativa boom (Allium sativum ) or Allium schoenoprasum , Oryza sativa and Oryza glaberrima . The method of claim 11, wherein the plant is oryza sativa or oryja glaberima.