KR20080062248A - Transdermal absorption patch - Google Patents

Abstract

A skin adhesive type transdermal absorption patch is provided to show excellent adhesive property compared to a conventional adhesive-dispersion type transdermal absorption patch by coating an adhesive layer for fixation on a support layer in a stripe or a net shape. A skin adhesive type transdermal absorption patch(100) comprises: a support layer(10); an adhesive layer for absorption(12) which is coated on a portion of the support layer surface for absorbing a drug; and an adhesive layer for fixation(14) which is coated on the surface of the adhesive layer for absorption and is characterized in that the adhesive layer for fixation is coated in a form of a line such as a linear line, a curved line, a zigzag line and a combination thereof, or a net such as a polygonal net, a circular net, a curved line net and a combination thereof. Further, a self-heat generating element is fixed on an outer surface of the support layer.

Description

Transdermal absorption patch

1 is a cross-sectional view illustrating an embodiment of the skin-derived transdermal absorbent according to the present invention;

2A to 2C are bottom views of the transdermal absorbent of FIG. 1, illustrating an example in which a fixing adhesive layer is coated in a strip form;

3A to 3C are bottom views of the transdermal absorbent of FIG. 1, illustrating an example in which a fixing adhesive layer is coated in a net form;

4 is a cross-sectional view illustrating another embodiment of the skin-derived transdermal absorbent according to the present invention;

5A to 5C are bottom views of the transdermal absorbent of FIG. 4, illustrating an example in which an absorbent pressure-sensitive adhesive layer is coated in a strip form;

6A to 6C are bottom views of the transdermal absorbent of FIG. 4, illustrating an example in which an absorbent pressure-sensitive adhesive layer is coated in a net form;

7A and 7B are cross-sectional views illustrating examples in which a self heating element is attached as another embodiment of the skin-derived transdermal absorbent according to the present invention.

<Explanation of symbols for the main parts of the drawings>

10: support layer 12: adhesive layer for absorption

14 fixing adhesive layer 16 magnetic heating element

100, 200, 300: Skin-derived transdermal absorbent

The present invention relates to a skin-derived transdermal absorbent, and more particularly, an absorbent pressure-sensitive adhesive layer mainly intended for drug absorption, and a fixing pressure-sensitive adhesive layer for the purpose of being adhered to the skin well in a stripe or net arrangement. It relates to a skin-derived transdermal absorbent of a novel structure coated with a.

In general, the structure of the skin-derived transdermal absorption agent may be divided in various ways depending on the distribution of the drug and the adhesive.

There is a drug reservoir in which the drug is dispersed in a polymer matrix or in a high viscosity liquid, and a membrane and pressure-sensitive adhesive layer which controls drug release between the drug storage layer and the skin. One example is a controlled membrane system.

As another example, an adhesive dispersion type, in which a drug is directly dispersed in an adhesive without a separate drug layer, a matrix in which the drug is dispersed in a polymer matrix and adhered to the skin, and the adhesive is applied to the drug-free edge. A matrix-diffusion controlled system.

Among these skin-derived transdermal absorbents, the most widely used adhesive dispersion type (adhesive dispersion type) is used, but in this case, the adhesive layer has to be dispersed together with various additives for absorbing the drug into the skin. There is a weakening problem.

Percutaneous absorbents that need to be applied to the skin for a long time should increase the amount of drug as well as the adhesion.

Therefore, by including only the adhesive without the drug on the edge of the pressure-sensitive adhesive layer including the drug layer, it has been intended to improve the adhesive force, but this has a problem that the process is complicated and the unit cost is increased, and also includes the drug in the center even if the edge is well attached There is a problem that the pressure-sensitive adhesive layer is not absorbed well off the skin.

In particular, in the case of a transdermal absorption agent that further improves absorption of the drug by applying heat, the occurrence of sweat occurs more frequently than other transdermal absorption agents, and thus there is a problem that the adhesive strength is further lowered.

The present invention has been made in view of the above point, the absorption adhesive layer for the main purpose of drug absorption, and the fixing adhesive layer for the purpose of being adhered to the skin well while forming a stripe or net arrangement on the support layer Its main purpose is to provide a skin-derived transdermal absorbent with a laminated structure.

Another object of the present invention is to provide a skin-derived transdermal absorbent having a structure in which a self-heating body is attached to heat each adhesive layer on a surface of a support layer coated with an absorbent adhesive layer and a fixing adhesive layer.

As one embodiment of the present invention for achieving the above object, a support layer; An absorbent pressure-sensitive adhesive layer coated on one surface of the support layer for drug absorption; It provides a skin-derived transdermal absorbent, characterized in that consisting of a fixed pressure-sensitive adhesive layer is laminated coating for the purpose of skin adhesion to the surface of the pressure-sensitive adhesive layer for absorption.

The fixing adhesive layer is characterized in that the coating in the form of a straight line, curved line, zigzag line or a combination thereof.

The width of the string coated with the fixing pressure-sensitive adhesive layer is characterized by having the same or different widths in the range of 100um ~ 10cm.

The fixing adhesive layer is characterized in that the coating in the form of a polygonal net, circular net, curved net, or a combination thereof.

The absorption pressure-sensitive adhesive layer is characterized in that to occupy 5 to 95% in the total area.

A magnetic heating element is attached to the outer surface of the support layer.

The fixing adhesive layer is characterized in that no drug or less than the amount of the drug dispersed in the absorbent adhesive layer.

The pressure-sensitive adhesives used in the absorbent pressure-sensitive adhesive layer and the fixing pressure-sensitive adhesive layer can be used the same or different.

The absorbent pressure-sensitive adhesive layer and the fixing pressure-sensitive adhesive layer is characterized in that it contains a polymer that absorbs moisture in either or both.

As another embodiment of the present invention for achieving the above object, a support layer; A fixing adhesive layer coated on one surface of the support layer for adhesion to the skin; It provides a skin-derived transdermally absorbent comprising a pressure-sensitive adhesive layer coated on the surface of the fixing pressure-sensitive adhesive layer for the purpose of drug absorption.

The absorbent pressure-sensitive adhesive layer is characterized in that the coating in the form of a straight line, curved line, zigzag line or a combination thereof.

The width of the string coated with the pressure-sensitive adhesive layer for absorption is characterized in that it has the same or different widths in the range of 100um ~ 10cm.

The absorbent pressure-sensitive adhesive layer is characterized in that the coating in the form of a polygonal net, circular net, curved net, or a combination thereof.

The absorption pressure-sensitive adhesive layer is characterized in that to occupy 5 to 95% in the total area.

A magnetic heating element is attached to the outer surface of the support layer.

The fixing adhesive layer is characterized in that no drug or less than the amount of the drug dispersed in the absorbent adhesive layer.

The pressure-sensitive adhesive used in the absorbent pressure-sensitive adhesive layer and the fixing pressure-sensitive adhesive layer is characterized in that the same or another can be used.

The absorbent pressure-sensitive adhesive layer and the fixing pressure-sensitive adhesive layer is characterized in that it contains a polymer that absorbs moisture in either or both.

Hereinafter, the present invention will be described in more detail with reference to the accompanying drawings.

1 to 3 show an embodiment of the skin-derived transdermal absorbent according to the present invention.

Transdermal absorbent 100 according to an embodiment of the present invention is first coated with an absorbent pressure-sensitive adhesive layer 12 for the purpose of drug absorption on one surface of the support layer 10, the surface of the pressure-sensitive adhesive layer 12 The fixing adhesive layer 14 is laminated for the purpose of skin attachment, and there is a focus on the coated structure.

The support layer may be made of a nonwoven fabric, a woven fabric, a film or a sheet alone or in combination, and the materials constituting the support layer may include natural or synthetic rubber, EVA, PE, polyurethane, latex, PET, PP, PVC, PS, PC, PETG, aluminum, etc. can be used singly or in combination.

In the absorbent pressure-sensitive adhesive layer 12, an effective drug and an additive to be absorbed through the transdermally are dispersed in the adhesive polymer, and the additive includes a solubilizer, a solubilizer, an absorption accelerator, and the like.

Here, additives such as solubilizers, solubilizers, and absorption accelerators are used to promote transdermal absorption of drugs. Since one substance plays a different role depending on the characteristics of the drug, the following substances are listed without classification; alcohols such as propylene glycol, glycerol, ethanol, octanol, lauryl alcohol, sulfoxide compounds such as DMSO, DMAC, DMF, NMF, DCMS, NMP, 2-pyrrolidone, 5-methyl-2-pyrrolidone, 1,5-dimethyl Interfaces with pyrrolidone-based compounds such as -2-pyrrolidone, fatty acid substances such as oleic acid, linoleic acid, hepanoic acid, capric acid, lauric acid stearic acid, palmitoleic acid, myristic acid, sodium lauryl sulfate, tween, cetyltrimetyl ammonium bromide There may be various essential oils such as activators, menthol, eucalyptol, terpene and terpenoids.

The fixing adhesive layer 14 may be free of drugs, or may be dispersed in the effective drug and additives as in the absorbent pressure-sensitive adhesive layer 12, but the amount thereof is smaller than that of the absorbent pressure-sensitive adhesive layer 12, and the pressure-sensitive adhesive layer is absorbed. Adhesive force is stronger than (12).

The pressure-sensitive adhesive used in the absorbent pressure-sensitive adhesive layer 12 and the fixing pressure-sensitive adhesive layer 14 may be the same or different, and any one of the absorption pressure-sensitive adhesive layer 12 and the fixing pressure-sensitive adhesive layer 14 may be used. One or both polymers that absorb moisture can be used.

Solvent type adhesives, emulsion type adhesives, hot melt type adhesives, etc. can be used as the adhesive used for the said absorption adhesive layer and a fixed adhesive layer. More specifically, a rubber-based adhesive, a vinyl acetate-based adhesive, an ethylene-vinyl acetate-based adhesive, a polyvinyl alcohol-based adhesive, a polyvinylacetyl-based adhesive, a vinyl chloride-based adhesive, an acrylic-based adhesive, a polyamide-based adhesive, a polyethylene-based adhesive, a cellulose A pressure sensitive adhesive containing a pressure sensitive adhesive, a polysulfide adhesive, or a hot melt polymer material may be used, and these may be used alone or in combination. In the case of fixing adhesives, adhesives that have no skin irritation and good adhesion are preferentially used.As an adhesive for absorption, a adhesive that can stably contain a drug to be used is preferentially used to play a role in promoting skin absorption. It is good.

When percutaneous absorbents are attached to the skin, the sweat discharged from the attachment site is trapped between the percutaneous absorbents and the skin, and thus, the percutaneous absorbents can be dropped from the skin, which causes the absorption of the drug. Incorporating moisture-absorbing substances into the adhesive can prevent this by absorbing sweat. Water absorbing materials include natural, synthetic, and modified natural polymers and materials, and include inorganic materials such as silica gel. Representative synthetic polymers include acrylic acid or acrylamide polymers and copolymers. Other celluloses such as hydroxypropyl starch, amylose, amylopectin, ethyl hydroxyethyl cellulose, hydroxypropyl cellulose, cellulose derivatives, and guar ( polygalactomannans such as guar or crob seed starch, oxidized starch, carboxylated phosphate starch, cellulose oxide, carboxymethylcellulose, carboxymethyl starch, carboxymethylcellulose (CMC), xanthan, alginate, Substances such as arabic gums can be used.

The skin-derived transdermal absorbent 100 according to the embodiment of the present invention has a structural feature in that the fixing adhesive layer 14 coated on the surface of the absorbent adhesive layer 12 has a stripe or net structure. There is this.

That is, the fixing adhesive layer 14 is coated on the surface of the absorbent pressure-sensitive adhesive layer 12 coated on the entire surface of the support layer 10 in the form of a stripe, or in the form of a net Have

More specifically, when the fixing pressure-sensitive adhesive layer 14 is coated in the form of a line, it may be coated in a straight, curved, or a combination thereof, as illustrated in the accompanying Figures 2a to 2c, respectively The coating width of may have different widths per line in the range of 100um ~ 10cm.

On the other hand, when the fixing pressure-sensitive adhesive layer 14 is coated in a net form, it may be coated in a polygonal, circular, curved, or a combination thereof as shown in Figure 3a to 3c.

Accordingly, the absorbent pressure-sensitive adhesive layer 12 coated on the entire surface of the support layer 10 between the string-type fixing adhesive layer 14 is exposed to the drug delivery to the skin, similarly the fixing adhesive of the net form An absorbent pressure-sensitive adhesive layer 12 is exposed between the layers 14 to enable drug delivery to the skin.

At this time, the exposed area of the absorbent pressure-sensitive adhesive layer 12 exposed between the fixing pressure-sensitive adhesive layer 14 may be adjusted to occupy 5 to 95% as necessary in the total area.

Here, the skin-derived transdermal absorbent according to another embodiment of the present invention will be described.

4 to 6 show a skin-derived transdermal absorbent according to another embodiment of the present invention.

Transdermal absorbent 200 according to another embodiment of the present invention is first coated with a pressure-sensitive adhesive layer 14 for the purpose of skin adhesion to one surface of the support layer 10, the surface of the pressure-sensitive adhesive layer 14 The main focus is on the laminated coating structure of the absorbent adhesive layer 12 for the purpose of drug absorption.

As in the above-described embodiment, the absorbent pressure-sensitive adhesive layer 12 has an effective drug to be absorbed through the transdermal and additives dispersed in the adhesive polymer, the additives include a solubilizer, a solubilizer, an absorption accelerator, and the like.

In addition, as in the exemplary embodiment, the fixing adhesive layer 14 may be free of drugs or the active drug and additives may be dispersed in the same manner as the absorbent adhesive layer, but the amount thereof is smaller than that of the absorbent adhesive layer 12. The adhesive strength is stronger than that of the absorbent pressure-sensitive adhesive layer 12, and the pressure-sensitive adhesive used in the absorbent pressure-sensitive adhesive layer 12 and the fixing pressure-sensitive adhesive layer 14 may be the same or different, and the absorbent pressure-sensitive adhesive layer Either or both of (12) and the adhesive layer 14 for fixing can be used as what contains the polymer which absorbs moisture.

The skin-derived transdermal absorbent 200 according to another embodiment of the present invention has a structural feature in that the absorbent adhesive layer 12 coated on the surface of the fixing adhesive layer 14 has a stripe or net structure. There is this.

That is, the absorbent pressure-sensitive adhesive layer 12 is coated on the surface of the fixing pressure-sensitive adhesive layer 14 coated on the entire surface of the support layer 10 in the form of a stripe, or a net-coated structure. Have

More specifically, when the absorbent pressure-sensitive adhesive layer 12 is coated in the form of a string, as shown in the attached Figures 5a to 5c can be coated in a straight, curved, or a combination thereof, respectively The coating width of may have different widths per line in the range of 100um ~ 10cm.

On the other hand, when the absorbent pressure-sensitive adhesive layer 12 is coated in a net form, it may be coated in a polygonal, circular, curved, or a combination thereof as illustrated in the accompanying Figures 6a to 6c.

Thus, the fixing adhesive layer is exposed to the skin between the string-type absorbent adhesive layer 12 so as to be attached to the skin, and similarly, the fixing adhesive layer 14 is placed between the net-type absorbent adhesive layer 12 and the skin. Is exposed to attach to.

At this time, the area of the absorbent pressure-sensitive adhesive layer 12 coated on the surface of the pressure-sensitive adhesive layer 14 may be adjusted to occupy 5 to 95% as necessary in the total area.

Herein, another embodiment of the skin-derived transdermal absorbent according to the present invention will be described.

7A and 7B show a skin-derived transdermal absorbent according to another embodiment of the present invention.

In the transdermal absorbent 300 according to another embodiment of the present invention, one of the absorbent pressure-sensitive adhesive layer 12 or the fixing pressure-sensitive adhesive layer 14 is coated on the entire backing layer 10, and the other pressure-sensitive adhesive is In the state of being coated in a stripe or net form, a self-heating body 16 is attached on the surface of the support layer to generate 35 ° C. to 45 ° C. to facilitate drug delivery of the absorbent pressure-sensitive adhesive layer 12 through heating. Take form.

Hereinafter, specific test examples and comparative examples of the present invention will be described, and the following examples and comparative examples are provided only to explain the present invention in detail, and the technical scope of the present invention is limited by them. no.

 Example 1

First, pyrocampam was dissolved in dimethyl sulfoxide and diethylene glycol monoethyl ether, and then lauricethanolamide and polyethylene glycol 200 monolaurate were added to the solution and mixed well. Bubbles were mixed well with isobutylene pressure-sensitive adhesive solution (National Starch, Duro-Tak87-2852) and allowed to stand. This solution is coated on a release paper at 400 μm, and the absorbent pressure-sensitive adhesive layer formed by drying at 70 ° C. for 10 minutes is transferred to a 50 μm urethane film.

 A 100um-thick release PET film with silicone release treatment on one side was coated with a pressure-sensitive adhesive (National Starch, Duro-Tak387-2287) on a 15cm width with 300μm of 0.5cm width at 2cm intervals. It applied using the bar and dried for 10 minutes at 70 ℃ to form a pressure-sensitive adhesive layer for fixing. The pressure-sensitive adhesive layers on both sides were bonded to each other, and then cut into appropriate sizes and sealed in an aluminum bag.

Example 2

First, a pressure-sensitive adhesive layer for absorption was prepared in the same manner as in Example 1. After that, put a 300um-thick sheet with 1cm * 1cm square holes spaced 1cm apart from each other on the 100um-thick release PET film with silicone release treatment on one side, and a pressure-sensitive adhesive (National Starch) , Duro-Tak387-2287) was applied and dried at 70 ° C. for 10 minutes to remove the perforated sheet to form a fixing adhesive layer. The pressure-sensitive adhesive layers on both sides were bonded to each other, and then cut into appropriate sizes and sealed in an aluminum bag.

 Example 3

 A pressure-sensitive adhesive (National Starch, Duro-Tak387-2287) was applied on a release paper at a thickness of 300 μm, dried at 70 ° C. for 10 minutes, and then transferred to a 50 μm urethane film to form a fixing adhesive layer.

After making the same drug solution as in Example 1, on the 100 μm thick release PET film having a silicone release treatment on one side, a coating bar having a width of 15 cm on the surface of the drug solution and having a width of 400 μm by 2 cm at 0.5 cm intervals. It applied and it was dried for 10 minutes at 70 degreeC, and the adhesive layer for fixation was created. Thereafter, both of the pressure-sensitive adhesive layers were laminated so as to adhere the pressure-sensitive adhesives, and then cut to an appropriate size.

Example 4

A fixing adhesive layer was fixed in the same manner as in Example 3. After that, put a 400um-thick sheet with 2cm * 2cm square holes spaced 2cm * 2cm apart on each side on a 100um-thick release PET film with silicone release treatment on one side, and apply drug solution. After drying for 10 minutes at room temperature to remove the perforated sheet to form a pressure-sensitive adhesive layer. Thereafter, both of the pressure-sensitive adhesive layers were laminated so as to adhere the pressure-sensitive adhesives, and then cut to an appropriate size.

Example 5

 A percutaneous absorption preparation was prepared in the same manner as in Example 3, but was prepared to have a higher concentration of pyroxycam.

 [Production Example 1]

50% by weight of iron, 10% by weight of activated carbon, 8% by weight of diatomaceous earth, 5% by weight of wood powder, 2% by weight of sodium chloride were weighed and mixed well to prepare a exothermic composition.

The exothermic composition powder was prepared by spreading it in a PE-permeable sheet and sealing, and then punching 150 pores / 100 cm 2 micropores on one surface of the manufactured sheet with an external diameter of 400 μm and an internal diameter of 250 μm. Water was sprayed at a weight of a quarter, and the sheet-like self heating element was placed in a non-breathable packaging bag and sealed in a vacuum state.

Example 6

After attaching the self heating element prepared in Preparation Example 1 to the surface of the support layer according to Example 1, the percutaneous absorbent agent with a self heating element was made by covering the urethane foam coated with a well-ventilated and pressure-sensitive adhesive on the net, and immediately Sealed in breathable bags.

Example 7

After attaching the self heating element prepared in Preparation Example 1 to the surface of the support layer according to Example 3, the percutaneous absorbent preparation with a self heating element was made by covering the urethane foam coated with a well-ventilated and pressure-sensitive adhesive net. Sealed in breathable bags.

Comparative Example 1

First, the drug solution was prepared in the same manner as in Example 1, and the solution was coated with 400 μm on 100 μm release PET, dried at 70 ° C. for 10 minutes, and then transferred onto a 50 μm thick urethane film. It was sealed and stored in an envelope.

Comparative Example 2

A percutaneous absorption preparation was made in the same manner as in Comparative Example 1, but the pyroxicam concentration was about Example 5.

Comparative Example 3

After attaching the self heating element prepared in Preparation Example 1 to the urethane film of the percutaneous absorption agent made in Comparative Example 1, the percutaneous absorption agent with self heating element was covered by covering the urethane foam coated with a well-ventilated adhesive on the net. made.

Experimental Example

 [Adhesiveness]

When the Examples and Comparative Examples were cut to the same size and attached to the skin, the initial adhesion of the first day and the adhesion after a predetermined time were compared. The results are shown in Table 1 below.

◎ Sticks well, ○ Some parts fall off, Δ Many parts fall off, X sticks

(Δ, X is a difficult state to use as a transdermal absorption agent)

As described above, the percutaneous absorption preparations according to the present invention (Examples 1, 2, 3, and 4) show better adhesion performance than the conventional adhesive-dispersion type percutaneous absorption preparations (Comparative Example 1) when the same drug is used. Although the adhesion performance is maintained high even if the concentration of the additive is increased (Example 5), in the case of the conventional adhesive-dispersion type transdermal absorption preparation (Comparative Example 2), if the concentration of drugs and additives is increased, the adhesion is difficult to use. Apart from this, it is difficult to make high concentrations of transdermal absorbents.

As shown in Table 2 above, when there is a self-heating element, a lot of sweat comes out as compared with a general transdermal absorbent due to heating, but in the case of the transdermal absorbent according to the present invention (Examples 6 and 7) Since the adhesion is maintained by the showed a better adhesion than the conventional product (Comparative Example 3).

As described above, according to the skin-derived transdermal absorbent according to the present invention, the absorbent pressure-sensitive adhesive layer for drug absorption and the fixing pressure-sensitive adhesive layer for the purpose of sticking well to the skin are stripe or net type. By being coated with, it has an advantage of excellent adhesion compared to conventional adhesive-dispersion type transdermal absorbents.

In addition, according to the present invention can increase the amount of drugs and additives to make a transdermal absorption preparation for long-term attachment.

In addition, according to the present invention, there is a fixing adhesive layer having a strong adhesive force between the existing pressure-sensitive adhesive layer can be made percutaneous absorbent agent having more excellent adhesion even when sweating a lot by attaching a self-heating body.

Claims (18)

A support layer; An absorbent pressure-sensitive adhesive layer coated on one surface of the support layer for drug absorption; A fixing adhesive layer laminated on the surface of the absorbent pressure-sensitive adhesive layer for adhesion to the skin; Skin-derived transdermal absorbent, characterized in that consisting of. The method of claim 1, wherein the fixing adhesive layer is a skin-derived transdermal absorbent, characterized in that the coating in the form of a straight line, curved line, zigzag line or a combination thereof. The skin-derived transdermal absorbent according to claim 1 or 2, wherein the width of the string coated with the fixing adhesive layer has the same or different widths in a range of 100 um to 10 cm. The method of claim 1, wherein the fixing adhesive layer is a skin-derived transdermal absorbent, characterized in that the coating in the form of a polygonal net, circular net, curved net, or a combination thereof. The skin-derived transdermal absorbent according to claim 1, wherein the pressure-sensitive adhesive layer occupies 5 to 95% of the total area. The skin-derived transdermal absorbent of claim 1, wherein a magnetic heating element is attached to an outer surface of the support layer. The skin-derived transdermal absorbent of claim 1, wherein the adhesive layer for fixation is free of drugs or less than the amount of the drug dispersed in the absorbent adhesive layer. The skin-derived transdermal absorbent according to claim 1, wherein the pressure-sensitive adhesive used in the absorbent pressure-sensitive adhesive layer and the fixing pressure-sensitive adhesive layer can be the same or different. The skin-derived transdermal absorbent according to claim 1, wherein a polymer absorbing moisture is contained in any one or both of the absorbent pressure-sensitive adhesive layer and the fixing pressure-sensitive adhesive layer. A support layer; A fixing adhesive layer coated on one surface of the support layer for adhesion to the skin; An absorbent pressure-sensitive adhesive layer coated on the surface of the pressure-sensitive adhesive layer for drug absorption; Skin-derived transdermal absorbent, characterized in that consisting of. The method of claim 10, wherein the pressure-sensitive adhesive layer is a skin-derived transdermal absorbent, characterized in that the coating in the form of a straight file, a curved file, a zigzag file or a combination thereof. The skin-derived transdermal absorbent according to claim 10 or 11, wherein the width of the cord coated with the pressure-sensitive adhesive layer has the same or different widths in a range of 100 um to 10 cm. The method of claim 10, wherein the pressure-sensitive adhesive layer is a skin-derived transdermal absorbent, characterized in that the coating in the form of a polygonal net, circular net, curved net, or a combination thereof. The skin-derived transdermal absorbent according to claim 10, wherein the pressure-sensitive adhesive layer occupies 5 to 95% of the total area. The skin-derived transdermal absorbent of claim 10, wherein a magnetic heating element is attached to an outer surface of the support layer. The skin-derived transdermal absorbent of claim 10, wherein the adhesive layer for fixation is free of drugs or less than the amount of the drug dispersed in the absorbent adhesive layer. The skin-derived transdermal absorbent according to claim 10, wherein the pressure-sensitive adhesive used in the absorbent pressure-sensitive adhesive layer and the fixing pressure-sensitive adhesive layer can be the same or different. The skin-derived transdermal absorbent according to claim 10, wherein a polymer absorbing moisture is contained in any one or both of the absorbent pressure-sensitive adhesive layer and the fixing pressure-sensitive adhesive layer.

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