KR20080035863A - Apparatus for measuring time-course glucose variation and system using the apparatus - Google Patents

Abstract

An apparatus for measuring time-course glucose variation and a system for measuring the time-course glucose variation using the same are provided to determine whether or not corresponding food is harmful to a wearer in real time. An apparatus(20) for measuring time-course glucose variation includes a body part(22) and a glucose measuring sensor part(24). The body part includes a control unit(210), a memory unit(220), a display unit(230), a key input unit(240), a communication interface unit(250), and an indication unit(260). The body part is attached to and detached from the glucose measuring sensor unit. The apparatus confirms the changes of the changed glucose variation visually according to the time after a wearer eats a specific food. The body part is used as a clock when the glucose measuring sensor part is not mounted. The glucose measuring sensor part measures the concentration of glucose in the blood varied by the glucose processed in a human body of a wearer by using a noninvasive method. The control unit measures values acquired by measuring glucose at two or more points of time and stores the values in the memory unit. Then, the control unit allows the values to be displayed on one screen of the display unit.

Description

Apparatus for measuring time-course glucose variation and system using the apparatus

1 is a graph illustrating the concept of a sugar index (GI).

2 is a block diagram schematically showing the internal configuration of the apparatus for measuring sugar metabolism change over time according to a preferred embodiment of the present invention.

3 is an exploded perspective view schematically illustrating a configuration of a sugar metabolism measuring sensor unit of a device for measuring sugar metabolism change over time according to a preferred embodiment of the present invention.

4 is a configuration diagram of a screen of the display unit exemplarily illustrated to describe the first embodiment of the controller of the apparatus for measuring glucose metabolism change over time according to a preferred embodiment of the present invention.

FIG. 5 is a graph illustrating a second embodiment of a control unit of the apparatus for measuring glucose metabolism change over time according to a preferred embodiment of the present invention.

6 is a graph illustrating a third embodiment of a control unit of the apparatus for measuring glucose metabolism change over time according to a preferred embodiment of the present invention.

Figure 7 is a block diagram showing the overall configuration of the blood glucose change measurement system according to a preferred embodiment of the present invention.

<Explanation of symbols for the main parts of the drawings>

20: device for measuring metabolic changes over time

22: main body

24: our metabolic measurement sensor unit

210: control unit

220: memory unit

230: display unit

240: key input unit

250: communication interface unit

260: notification unit

300, 302: hydrophilic polymer gel

310: base film

320: electrode portion

330: insulating film

340: gel fixing part

350: guide part

70: blood sugar change measurement system over time

80: managed computer

90: blood sugar value management program

92: database

The present invention relates to a device for measuring glucose metabolism change over time and a system using the same, and more specifically, the glucose metabolism in the human body periodically for a certain period of time after ingesting a specific food using a glucose-measuring sensor of bloodless type. Measurement of changes in glucose metabolism over time, which enables the user to visually check the state of change over time of the values representing the measured glucose metabolism, thereby determining whether the food is harmful to obesity and health care of the wearer. The present invention relates to a system for measuring glucose metabolism change over time by using a device and a device for measuring glucose metabolism change over time.

In the 1990s, a research team at the University of Toronto, Canada, found that there was a difference in postprandial blood sugar changes caused by different types of carbohydrate foods. For example, potato or corn flakes cause sugar metabolism more rapidly than brown rice, cereals, and oatmeal. As a result, research has been reported to raise blood glucose levels in the human body and thereby result in a large amount of insulin in the blood.

In other words, the rate at which carbohydrates we eat as food is converted to glucose in the body and absorbed by the body depends on the food. By the way, in the case of a slow food carbohydrate is converted to glucose, since the glucose is supplied at a slow rate after ingestion is used as an energy source in the body, glucose is not accumulated in the form of fat in the human body. However, foods that convert carbohydrates into glucose rapidly increase glucose levels in the body after ingesting them, resulting in large amounts of insulin that temporarily send large amounts of glucose to other organs or muscles The remaining glucose is converted back into fat by insulin and accumulates in fat cells. Therefore, eating foods that show a sudden change in glucose levels promotes insulin secretion, and gaining weight, while eating foods that show slower glucose levels change can minimize insulin secretion and thereby lose weight. Since these glucose levels have nothing to do with food calories, there is no pain in reducing or starving if you are trying to diet by eating foods that show slow glucose levels. In addition, if you eat less carbohydrates and eat only foods of the same type with low sugar levels, the increase in glucose levels in the blood is slowed and insulin secretion is suppressed, which prevents obesity, diabetes, and adult diseases caused by excessive secretion of insulin. And improvement is also known.

As a result of these studies, the difference in glucose change that occurs in different foods was quantified, which is called the glycemic index (GI). GI set the glycemic index for pure glucose to a standard value of 100 and the other foods based on the standard value. More specifically, after the intake of each food, the number indicating the ratio of the glucose concentration in the blood converted by the sugar metabolism of carbohydrates in the corresponding food to the reference value 100 is the GI for each food. For example, some foods have GI levels compared to 100 glucose. White bread = 70, white rice / brown rice = 72/66, corn 59, potatoes 80, carrots 92, popcorn 79 and the like.

1 is a graph showing the GI, showing the change in the concentration of glucose in the blood by glucose metabolism during ingestion of carbohydrate for 2 hours, (a) is a graph showing the GI standard value, (b) is white bread Is a graph depicting a GI curve showing a change in blood glucose concentration for.

 Each food is divided into three high, medium, and low groups according to their GI levels. The high GI group is 70 or more, the middle GI group is 50 to 69, and the low GI group is 49 or less.

High GI means carbohydrates are rapidly broken down into glucose, so foods high in GI are fast and high in metabolism. On the contrary, low GI means that carbohydrates are broken down into glucose, and thus, low GI foods have a slower metabolism, and slowly release glucose into the blood.

However, the above-mentioned GI has a problem in that the levels of carrots and popcorn, which are weak in sugar components, are excessively high. This is due to the fact that the main ingredient of the popcorn, which is mainly carrot and air, is the main ingredient.

To solve this unreasonable point of GI index, the concept of glycemic load (hereinafter referred to as 'GL') has been newly introduced. GL is a number obtained by dividing the GI of food by 100, and multiplying the amount of carbohydrates in the food by gm, as shown in Equation 1.

GL = GI / 100 × Carbohydrate

GL having the above-mentioned characteristics is divided into the following three high, medium, and low groups according to the GL value of each food. The high GL group is above 20, the middle GL group is 11 ~ 19, and the low GL group is below 10.

That GL food has the following characteristics: (1) low blood sugar after meals. (2) helps with weight loss. (3) improve the insulin effect (Sensitivity). (4) helps to reuse carbohydrates accumulated in the body after exercise. (5) long lasting food energy effect.

Therefore, Applicant uses the basic principles of GI and GL to identify glucose concentrations in the blood that are altered by glucose metabolism for ingested foods, thereby providing optimal dietary intake for diabetic and obese patients on diet. I would like to propose an inducible solution.

An object of the present invention for solving the above problems is to continuously measure the change in glucose concentration in the blood, which is changed by the glucose metabolism in the human body during a certain time interval after food intake and to provide a visual result of the measurement It is to provide a device for measuring the metabolic change over time.

In addition, another object of the present invention is to periodically measure the change of glucose metabolism automatically for a certain period of time to completely decompose into glucose after ingesting a specific food, and to determine the harmfulness of the ingested food through the measurement results It is to provide a device for measuring the metabolic change over time.

In addition, another object of the present invention is to provide a blood glucose change measuring system that provides various types of glucose metabolism-related information to a wearer who wears the device by using the above-described sugar metabolic change measuring device.

The device for measuring glucose metabolism change over time according to a feature of the present invention for achieving the above-described technical problem is a glucose metabolism measurement sensor unit for providing a glucose metabolism measurement signal, and a glucose metabolism measurement signal provided from the glucose metabolism measurement sensor unit. It consists of a main body for outputting predetermined information by using,

The main body portion

A display unit for displaying predetermined data,

A memory unit for storing predetermined data,

The sugar metabolism measurement sensor unit measures sugar metabolism values at at least two points of time for a predetermined measurement time, stores the measured sugar metabolism values in the memory unit, and then stores a time axis on one screen of the display unit. It is provided with a control unit to display sequentially based on the reference, so that the wearer can visually check the change in the glucose metabolism value changes over time after ingesting a particular food.

The control unit of the main body of the apparatus for measuring glucose metabolism change over time extracts the entire distribution range of sugar metabolism values during the measurement time, and the sugar sugar metabolism value distribution range is a reference sugar metabolism value distribution preset in the memory unit. Search for a corresponding level among the levels, and read information from the memory unit indicating the level of food hazard corresponding to the searched level and output it to the display unit;

The controller calculates an area under the curve (AUC) of the sugar metabolism distribution curve formed by the measured sugar metabolism values, and outputs the calculated AUC value on a screen of the display unit, wherein the memory unit The reference AUC value previously stored is compared with the calculated AUC value, and according to the comparison result, it is determined whether the wearer is obese and / or harmful to health care according to the ingested food, and the determination result is output to the display unit. Or

The controller calculates a slope due to the metabolic values at two or more time points consecutive in time, and outputs the calculated slope on a screen of the display unit, wherein the controller is configured to set the reference slope previously set for the corresponding section. It is preferable to read from the memory unit, compare the read reference slope with the calculated slope, determine whether the ingested food is harmful according to the comparison result, and output the determination result to the display unit.

The sugar metabolism measuring sensor unit of the sugar metabolism change measuring device having the above-described characteristics,

First and second hydrophilic polymer gels containing enzymes that react with glucose to generate chemical signals, and

It is formed of a material having an electrical conductivity, and consists of a first extraction electrode, a second extraction electrode, a working electrode, a counter electrode and a reference electrode, the first extraction electrode is formed to extend from the first sensing region to be connected to the body portion. The second extraction electrode extends from the fifth sensing region to be connected to the main body, and the working electrode, the counter electrode, and the reference electrode extend from the second sensing region, the third sensing region, and the fourth sensing region, respectively. The first, second, third, and fourth sensing regions are positions corresponding to the first hydrophilic polymer gel, and the fifth sensing regions are positions corresponding to the second hydrophilic polymer gel. It is preferable to have an electrode portion characterized in that, it is preferable to measure the glucose concentration in the blood according to the change of sugar metabolism in a bloodless manner.

Hereinafter, with reference to the accompanying drawings will be described in detail the configuration and operation of the glucose metabolism change measuring device over time according to a preferred embodiment of the present invention. 2 is a block diagram schematically illustrating a configuration of the apparatus for measuring sugar metabolism change over time according to a preferred embodiment of the present invention.

Referring to FIG. 2, the apparatus for measuring glucose metabolism change over time according to the present invention includes a body portion 22 and a sugar metabolism measuring sensor portion 24, and the body portion 22 is a controller 210. And a memory unit 220, a display unit 230, a key input unit 240, a communication interface unit 250, a notification unit 260, and the like. The main body portion 22 further includes electrode terminals on an outer surface thereof, and makes electrical contact with the glucose metabolism measuring sensor portion 24 through the electrode terminals.

Time-measuring metabolic change measuring device 20 having the above-described configuration is manufactured in a form that can be worn on a predetermined part of the human body, such as a watch as a whole, so that the metabolic value for the patient can be periodically measured, Periodically measured sugar metabolism values can be used to visually provide a state of change of sugar metabolism over time. In addition, the time-measuring metabolic change measuring device 20 is capable of attaching and detaching the sugar metabolism measuring sensor unit 24 to the body portion 22, so that the sugar metabolism measuring sensor unit 24 is not mounted. The body portion 22 can also be used as a watch. Hereinafter, each component described above will be described in detail.

The glucose metabolism measuring unit 24 is a sensor for measuring the concentration of glucose in the blood (hereinafter referred to as 'sugar metabolism') changed by the glucose metabolism proceeding in the wearer's human body using a bloodless method, According to a control signal from the control unit, the metabolic measurement signal is obtained through the skin of the wearer and then transmitted to the main body unit. Hereinafter, the structure and operation of the metabolic measurement sensor unit 24 will be described in detail with reference to FIG. 3.

The metabolic measurement sensor unit 24 includes two hydrophilic polymer gels 300 and 302, a base film 310, an electrode unit 320, an insulating film 330, a gel fixing unit 340, and a guide unit 350. It is provided.

The hydrophilic polymer gels 300 and 302 include glucose oxidase which reacts with glucose to generate a chemical signal, and may include any medium capable of moving an ionic material when a current is applied. have. The hydrophilic polymer gel includes a conductive polymer gel and a hydrophilic polymer gel. Preferably, the hydrophilic polymer gel is an ion conductive hydrophilic polymer gel. The ion conductive hydrophilic polymer gel may provide a property that can be electrically connected to an extraction electrode for extracting glucose in the cell liver fluid and a detection electrode for detecting the extracted glucose by the surface and electrical reverse iontophoretic contact with the skin, respectively. Any number may be included. The enzyme included in the hydrophilic polymer gel may include any enzyme that reacts with glucose to generate a chemical signal, and most preferably glucose oxidase. The chemical signal may be a substance formed by the enzyme from the glucose or a derivative thereof. For example, the chemical signal may be hydrogen peroxide. The enzyme may be included in either or both of the hydrophilic polymer gels.

The base film 310 is formed with an electrode portion 320 on the upper surface.

The electrode unit 320 is formed on the base film 310 and includes a first extraction electrode 322, a second extraction electrode 324, a working electrode 325, a counter electrode 326, and a reference electrode 327. . The first extraction electrode 322 extends from the first sensing region of the base film to be connected to the main body 22, and the second extraction electrode 324 extends from the fifth sensing region of the base film. The working electrode 325, the counter electrode 326, and the reference electrode 327 extend from the second sensing region, the third sensing region, and the fourth sensing region of the base film, respectively. It is formed to be connected to the body portion 22. The first, second, third and fourth sensing regions of the base film on which the electrode portion is formed are formed at positions corresponding to the first hydrophilic polymer gel 300, and the fifth sensing region is the second hydrophilic region. It is formed at a position corresponding to the polymer gel 302.

The insulating layer 330 is a film disposed on the upper part of the electrode part 320 to fix the electrodes of the electrode part 320 and to insulate adjacent electrodes from each other. The insulating layer 330 may be made of any insulating material (for example, polyethylene (PE)) known in the art.

The first extraction electrode 322 and the second extraction electrode 324 are connected to power in opposite directions, respectively. When a constant current is applied to the first and second extraction electrodes, a current is applied to intracellular transdermal fluid through a hydrophilic polymer gel in contact with the skin, thereby making the cationic glucose interact with a cation such as sodium in the intracellular fluid. It accumulates in the hydrophilic polymer gel through the skin. Glucose accumulated in the hydrophilic polymer gel, an ion conductive medium, generates hydrogen peroxide by glucose oxidase immobilized in the hydrophilic polymer gel, and the generated hydrogen peroxide is applied between the working electrode 325 and the reference electrode 327. It is oxidized by a constant voltage which is generated to generate a current.

The working electrode 325, the counter electrode 326, and the reference electrode 327 are extracted from intracellular transdermal fluid by reverse iontophoresis, and glucose accumulated in the hydrophilic polymer gel is combined with glucose oxidase immobilized on the hydrophilic polymer gel. It serves as a detection electrode for detecting the electrical signal generated by electrochemically oxidizing the hydrogen peroxide produced by the reaction.

Materials of the first and second extraction electrodes, working electrodes, counter electrodes, and reference electrodes are not particularly limited, but may include platinum (Pt), gold (Au), silver (Ag), and electrodes including carbon (C) in them. Or a silver / silver chloride (Ag / AgCl) electrode, but is not limited thereto.

The first extraction electrode 322 is positioned corresponding to one of the hydrophilic polymer gels, and the second extraction electrode 324 is positioned corresponding to the other hydrophilic polymer gel 302 and the working electrode 325. Is provided to surround most of the periphery of the counter electrode, and the counter electrode 326 is provided to surround most of the perimeter of the second extraction electrode 324, and the reference electrode 327 is a portion where the counter electrode does not extend. At may be provided around the second extraction electrode. Here, each electrode may have a connecting portion extending to connect to the terminal.

The gel fixing part 340 serves to fix the glucose metabolism measuring part to the wearer's skin during use, and a double-sided adhesive tape or the like may be used. Therefore, even if there is no frame for fixing the hydrophilic polymer gel by the gel fixing part, the hydrophilic polymer gel can be stably fixed to the skin, thereby protecting the hydrophilic polymer gel from the movement of the wearer.

The gel fixing part has a shape capable of covering an upper area of the base film 310 except for the sensing areas and an upper area of the electrode part. That is, the gel fixing part has openings 343 and 344 exposing the sensing area of the base film 310. As a result, the hydrophilic polymer gel is disposed in the opening of the gel holding part, and the electrical signal generated in the hydrophilic polymer gel can be transmitted to the body part through the electrode part.

The guide portion 350 is fixed to the lower portion of the base film 310 to allow the sugar metabolism measuring sensor to be entirely supported.

Hereinafter, the configuration and operation of the main body portion 22 of the sugar metabolism change measuring apparatus 20 according to the present invention will be described in detail.

The main body 22 operates in a clock mode when the glucose metabolism measuring sensor 24 is not mounted to display the current time on a screen of the display. In addition, when the glucose metabolism measuring sensor 24 is mounted, the main body 22 periodically extracts a sugar metabolism value using sugar metabolic measurement signals input from the sugar metabolism measuring sensor 24. The extracted glucose metabolism values and the sugar metabolism change state that change with time are displayed. Hereinafter, the configuration and operation of each element constituting the main body portion 22 will be described in detail.

The control unit 210 controls the overall operation of the metabolic change measuring device 20, a detailed description of the operation of the control unit will be described later.

The memory unit 220 may store information on preset reference values, store sugar metabolic values measured at various time points, or store the sugar metabolic values together with measurement time information.

The display unit 230 may be a liquid crystal display (LCD), a plasma display panel (PDP), or the like. The display unit 230 may display a metabolic value, a graph, or the like at the present time.

The key input unit 240 may include a mode selection button, a confirmation button, a left and right arrow buttons, and the like, and may further include a numeric key.

The communication interface 250 may transmit / receive data with an external computer or the like by using a universal serial bus (USB) or an RS232 serial communication module. The communication interface 250 is equipped with a wireless communication module widely used in a home network such as Zigbee, Bluetooth, UWB (Ultra-wideband) as well as wired communication, and wirelessly transmits data to an external computer or the like. You can also send and receive.

The notification unit 260 may include a display unit, a buzzer sound generator, or the like, or may selectively include one or more of them. The display unit may include three color light emitting diodes (LEDs), and the buzzer sound generator may include a buzzer. The control unit can turn on the corresponding LED (Turn-On) or operate the buzzer according to the degree of risk for the measured metabolic value, it is possible to inform the wearer of the metabolic change state in real time.

The controller 210 periodically measures the glucose metabolism value for a predetermined time from the moment when the start button is input to the end time, and changes the sugar metabolism state according to time using the sugar metabolism values measured at each time point. The display is displayed on the display unit, and a warning message is sent to the user through the notification unit when the reference value is exceeded by comparing the data measured by the metabolic metabolic state over time with a preset reference value. Hereinafter, various embodiments will be described in which the control unit 210 provides a change state of the sugar metabolism over time on the screen of the display unit by using the sugar metabolism values measured at least two time points or more.

First embodiment

Figure 4 (a) is a graph shown on the screen of the display unit according to the first embodiment of the control unit of the time-measuring metabolic change measuring device according to the present invention, Figure 4 (b) is an example of each level Defined histogram.

When a start signal is input from a user, the controller periodically operates the glucose metabolism measuring unit at a preset time interval from the start time t _START to the end time t _END to automatically measure sugar metabolism values. do. For example, since it takes about 2 hours for most of the ingested foods to be converted to glucose, the interval is 20 minutes every 2 hours from the start time t _START to the start time t _END . Therefore, the metabolic values are continuously measured.

As shown in (a) of FIG. 4, the control unit measures the metabolic values measured at each time point t ₀ , t ₁ , t ₂ , t ₃ , t ₄ , t ₅ , t ₆ during the measurement time ( G ₀ , G ₁ , G ₂ , G ₃ , G ₄ , G ₅ , G ₆ ) are sequentially displayed in the form of a graph on the screen of the display unit to visually display a graph of changes in glucose metabolism over time by ingested food. Will be provided. At this time, the X axis of the graph represents the time (min), the Y axis represents the sugar metabolism value (mg / dl).

Next, the controller extracts a distributed range of the measured metabolic values.

On the other hand, as shown in Fig. 4B, the distribution range of the metabolic value is classified into a predetermined number in advance, the level is assigned to each distribution range, and the allocation information is registered in the memory unit. For example, the first level is 19 or less, the second level is 20 to 29, the third level is 30 to 39, and the fourth level is 40 to 49, indicating low GI foods, the fifth level is 50 to 59, and the sixth level. Are 60 to 69, representing heavy GI foods, and the seventh level is 70 or more, indicating high GI foods.

Next, the control unit reads the information on the sugar metabolic value distribution range from the memory unit and uses the information on the sugar metabolic value distribution range read from the memory unit to correspond to the extracted sugar metabolic value distribution range. Is detected and information about the level is output on the screen.

2nd Embodiment

5 is a graph for explaining the AUC value according to the second embodiment of the control unit of the time-measuring metabolic change measuring device according to the present invention.

The control unit first performs sugar metabolism at each time point (t ₀ , t ₁ , t ₂ , t ₃ , t ₄ , t ₅ , t ₆ ) on a graph consisting of an X axis indicating time and a Y axis indicating sugar metabolic value. After displaying the values (G ₀ , G ₁ , G ₂ , G ₃ , G ₄ , G ₅ , G ₆ ) sequentially to form a curve, the area under curve (AUC) (500 area of Fig. 5B) is measured.

Next, after reading the reference AUC value set in advance and stored in the memory unit, the measured AUC value is compared with the read reference AUC value (region 510 of FIG. 5A). If the measured AUC value is larger than the reference AUC value, it is determined that the food is a high GI food and the notification unit is operated to notify the wearer.

In this case, the reference AUC value refers to an AUC value based on a curve formed by a food having a GI of 50 to 69, that is, a moderate GI food.

Third embodiment

FIG. 6 is a graph illustrating the inclination measured by the glucose metabolism values of the neighboring viewpoints according to the third embodiment of the controller of the apparatus for measuring glucose metabolism change over time according to the present invention.

Referring to FIG. 6, the controller may control the first glucose metabolism value G ₀ and the second glucose metabolism value G ₁ , which are sugar metabolism values at two time points (eg, t ₀ and t ₁ ) measured at the most recent time. The slope (Grad (t ₀ -t ₁ ) in FIG. 6 (b)) with respect to the connecting straight line is calculated. Here, the slope is defined as the rate of change of the metabolic change ΔG (G ₀ -G ₁ ) according to the time change Δt (t ₁ -t ₀ ).

On the other hand, the reference slope (Grad _{ref in} FIG. 6 (a) of FIG. 6) for a corresponding section set in advance and stored in the memory unit is read from the memory unit. Next, the calculated slope Grad (t ₀ -t ₁ ) is compared with the read reference slope Grad _ref . If the calculated slope is larger than the reference slope, it is determined that the food is a food having a high glycemic index (GI), and a notification unit or the like is operated to notify the user.

In this case, the reference slope stored in the memory unit is preferably a slope for each section with respect to the glucose metabolism change curve due to moderate GI food.

The apparatus for measuring glucose metabolism change over time according to various embodiments of the present invention measures glucose metabolism periodically for 2 hours from the time of ingesting a specific food, and the distribution range of sugar metabolism values from sugar metabolism values according to time, By selectively checking the AUC values for the sugar metabolic distribution curves and the slopes formed by the sugar metabolism values at neighboring time points, it is determined whether the food is harmful to the wearer, and the result is displayed on the wearer through the display unit or the notification unit. You will be informed.

Hereinafter, the configuration and operation of the time-measuring metabolic change measuring system 70 using the time-measuring metabolic change measuring device having the above-described configuration will be described in detail.

The system for measuring metabolic change over time according to the present invention includes a management computer 80, a database 92, and at least one device for measuring metabolic change over time.

The metabolic change measuring device 20 over time transmits data on sugar metabolism values measured at each time point to the management computer using a communication interface unit.

The management computer 80 may include a communication interface unit capable of transmitting and receiving data to and from the glucose metabolism change measuring device over time, and a sugar metabolism value management program for managing sugar metabolism values received from the sugar metabolism change measuring device over time ( 90).

The communication interface unit of the management computer is composed of a communication module using the same communication protocol as that of the apparatus for measuring metabolic change over time.

The sugar metabolism value management program 90 includes a sugar metabolism value storing module and a retrieval module. The glucose metabolism value storing module checks whether the glucose metabolism value is a glucose metabolism value when data is received from the glucose metabolism change measurement device over time, and then stores the received glucose metabolism value and time information on the sugar metabolism value in the database 92. The identification tag is input from an administrator and stored in the database along with the metabolic value and time information. At this time, by setting the identification tag to the name of the relevant food, it is possible to build a sugar metabolism change database for each food.

The search module retrieves information corresponding to a tag input from an administrator from the database, and displays the retrieved information on the screen in the form of a graph selected by the administrator.

The metabolic change measuring system having the above-described configuration stores and manages the sugar metabolism change hourly for each food type and the metabolic change state information for a predetermined time interval in the database 92, and at the request of the user. Information about a particular food is retrieved from the database so that the information can be provided in various types of graphs and charts.

Although the present invention has been described above with reference to preferred embodiments thereof, this is merely an example and is not intended to limit the present invention, and those skilled in the art do not depart from the essential characteristics of the present invention. It will be appreciated that various modifications and applications which are not illustrated above in the scope are possible. And differences relating to such modifications and applications should be construed as being included in the scope of the invention defined in the appended claims.

According to the present invention, after the wearer ingests a particular food, the user can visually check the state of the metabolic value change for a predetermined time due to the food. In addition, according to the present invention, by calculating the glucose metabolism change state, the AUC value for the glucose metabolism distribution curve, the slope by the glucose metabolism values at neighboring time points, and the like, by comparing with the reference values In addition, it is possible to simply determine in real time whether the food is harmful to the wearer.

In this way, by checking the change in the glucose metabolism value of the ingested food in real time, obese patients and diabetics can not only protect their health, but also eat only the foods that are beneficial to their health. It can be maintained.

Claims (13)

A sugar metabolism measuring sensor unit for providing a sugar metabolism measuring signal; And It is made of a main body portion for outputting predetermined information using the sugar metabolism measurement signal provided from the sugar metabolism measurement sensor unit, The main body portion A display unit which displays predetermined data; A memory unit for storing predetermined data; The sugar metabolism measurement sensor unit measures sugar metabolism values at at least two points of time for a predetermined measurement time, stores the measured sugar metabolism values in the memory unit, and then stores a time axis on one screen of the display unit. A control unit which sequentially displays the reference; Equipped with a glucose metabolism change measurement device, characterized in that the wearer can visually check the change in sugar metabolism value that changes with time after ingesting a particular food. The method of claim 1, wherein the controller extracts the entire distribution range of sugar metabolism values during the measurement time, and searches for a level corresponding to the sugar sugar metabolism value distribution range corresponding to among the reference sugar metabolism distribution levels preset in the memory unit. And reading information indicating the level of food hazard corresponding to the retrieved level from the memory unit and outputting the information to the display unit. The display apparatus of claim 1, wherein the controller calculates an area under the curve (AUC) of the sugar metabolic value distribution curve formed by the measured sugar metabolism values, and outputs the calculated AUC value to a screen of the display unit. Time-measuring metabolic change measuring device, characterized in that. The method of claim 3, wherein the memory unit stores a preset reference AUC value. The control unit compares the reference AUC value read from the memory unit with the calculated AUC value, and determines whether there is a risk of obesity and / or health care of the wearer according to the ingested food according to the comparison result, and the determination result The metabolic change measuring device over time characterized in that the output to the display unit. 5. The apparatus of claim 4, wherein the reference AUC value is an AUC value of a glucose metabolism change curve for a food having a moderate glycemic index (GI). 6. The temporal metabolic change measurement of claim 1, wherein the controller calculates a slope due to the metabolic values at two or more time points consecutive in time, and outputs the calculated slope on a screen of the display unit. Device. The method of claim 6, wherein the memory unit stores reference slopes of the metabolic values for each section, The control unit reads a reference slope for a corresponding section from the memory unit, compares the read reference slope with the calculated slope, determines whether the intake of food is harmful or not, and determines the harmfulness of the ingested food. The metabolic change measuring device over time characterized in that the output to. The apparatus of claim 7, wherein the reference slope comprises reference slopes of sugar metabolism values for each section of the food having a moderate GI. According to claim 1, The metabolic metabolic change measuring device further comprises a key input consisting of at least one button, The controller stores information on two or more sugar metabolism values measured during the measurement time interval in the memory unit, and stores the name input from the user through the key input unit as an identification tag. Party metabolic change measuring device. According to claim 1, The metabolic metabolic change measuring device is provided with at least one notification unit, And the control unit determines change of the metabolism over time according to the determination result of the measured metabolic values. The apparatus of claim 1, wherein the glucose metabolism measuring sensor measures a glucose metabolism value by using a bloodless method. The said metabolism measuring sensor part in any one of Claims 1-10, First and second hydrophilic polymer gels containing enzymes that react with glucose to generate chemical signals, It is formed of a material having an electrical conductivity, and consists of a first extraction electrode, a second extraction electrode, a working electrode, a counter electrode and a reference electrode, the first extraction electrode is formed to extend from the first sensing region to be connected to the body portion. The second extraction electrode extends from the fifth sensing region to be connected to the main body, and the working electrode, the counter electrode, and the reference electrode extend from the second sensing region, the third sensing region, and the fourth sensing region, respectively. The first, second, third, and fourth sensing regions are positions corresponding to the first hydrophilic polymer gel, and the fifth sensing regions are positions corresponding to the second hydrophilic polymer gel. Electrode part which is characterized in that Glucose metabolism change measuring device characterized in that for measuring the glucose concentration in the blood in accordance with the change of glucose metabolism in a bloodless manner. The method of claim 12, wherein the detection unit and the hydrophilic polymer gel of the sugar metabolism measuring sensor unit uses a reverse iontophoresis method for extracting an analyte from a biological system.

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