KR20070031401A - Substrate based skin care device - Google Patents

Abstract

The present invention discloses a skin care device comprising (1) a dermatologically acceptable preformed substrate and (2) a flavonoid compound, comprising a liquid medium for delivering the flavonoid compound.

Skin care devices, base materials, flavonoids, liquid media, whitening, anti-aging

Description

Base type skin care device {SUBSTRATE BASED SKIN CARE DEVICE}

The present invention relates to a substrate based skin care device that provides various skin care effect improvements such as skin whitening and anti aging.

Various skin treatments delay skin hyperpigmentation (mushrooms, freckles, spots, darkening, paleness, uneven tones, etc.), wrinkles, and other long-term changes typically associated with skin aging or environmental damage to human skin It is proposed to minimize, or even eliminate. Such treatments range from the application of specialty cosmetics such as packs and masks, oral intake of vitamins to chemical peels, laser surgery, photofacial and others. It is generally believed that effective treatment requires more time, physical and financial commitment. Effective, safe, and reasonably priced, there is a great demand for treatment that consumers can use every day.

Various skin lightening and anti aging agents are known in the art. It is also known that combinations of active agents may provide a synergistic effect. Flavonoids for use on the skin, such as hesperidin, are known in the art, such as Japanese Patent Application Laid-Open No. A11-346792, Japanese Patent Publication A2002-255827, Japanese Patent Publication A2003-137734, and US Patent Publication Known from 2002/13481.

Substrate skin care devices, such as masks and patches, are becoming increasingly popular as a slightly complex but effective means of providing special treatments in consumer homes. In general, consumers expect relatively high efficacy from these products. Substrate skin care devices typically comprise an amount of an aqueous liquid composition that is greater than the amount of saturation. When applying such a substrate type skin care device to a given area of skin, the temperature of the given skin surface is significantly lowered due to such abundant water. Such drop in temperature may provide a positive refreshing feeling to the consumer, but it may also act negatively in terms of penetration of the skin active agent. That is, the penetration of the active agent through the skin is slowed down as the skin surface temperature decreases. In view of skin penetration through a substrate-type skin care device, a skin active agent that mitigates the skin surface temperature drop is desired.

Based on the foregoing, there is a need for a substrate type skin care device that, when applied to the skin, also provides an improved skin conditioning effect while alleviating the skin surface temperature drop. Specifically, there is a need for a substrate type skin care device that provides a skin lightening effect and / or an anti-aging effect.

None of the existing techniques provide all the advantages and effects of the present invention.

Summary of the Invention

The present invention relates to a skin care device, the skin care device

(1) a dermatologically acceptable preformed substrate; And

(2) from about 0.001% to about 10% of a flavonoid compound,

The device comprises a liquid medium for delivering the flavonoid compound.

The present invention also relates to a method for providing a skin lightening effect, the method comprising applying the aforementioned device to the skin.

The present invention also relates to a method of providing the skin with an anti-aging effect, the method comprising applying the aforementioned device to the skin.

These and other features, aspects, and advantages of the present invention will become apparent to those skilled in the art upon reading the disclosure of the present invention, including the appended claims.

While this specification concludes with the claims that specifically point out and specifically claim the invention, it is believed that the invention will be better understood from the following detailed description.

All percentages, parts and ratios are based on the total weight of the compositions of the invention unless otherwise specified. All weights associated with the listed ingredients are based on activity level and therefore do not include carriers or by-products that may be included in commercially available materials.

All ingredients, such as other ingredients and active agents, useful in the present invention may be classified or described by their cosmetic and / or therapeutic effect or their desired mode of action. However, it should be understood that other ingredients or active agents useful in the present invention may in some cases provide more than one cosmetic and / or therapeutic effect or operate with more than one mode of action. Therefore, classifications herein are made for convenience and are not intended to limit the ingredients to the applications specifically mentioned or listed applications.

As used herein, the term "preformed" means that the article is made into a shape having a predetermined shape and size, which article can be removed from any relevant packaging by a finger without further preparation by the user. It can be removed and placed or covered onto the target surface. The term “preformed” also means that upon completion of manufacture, the article is substantially maintained in its shape at the desired normal storage temperature when the article is placed on a flat surface. Nevertheless, the article may bend or deform when applied or pressed to an uneven surface.

Flavonoid compounds

The device of the present invention comprises a flavonoid compound. As described below, the flavonoid compound is about 0.001% to about 10%, preferably about 0.01% to about 5%, more preferably, based on the weight of the liquid composition, gel sheet, or coating composition of the device of the present invention. Is used at a level of about 0.05% to about 1%. Flavonoid compounds are known to provide antioxidant, UV absorbing and radical scavenging effects. Flavonoid compounds are also known to be effective at enhancing collagen structure.

Flavonoid compounds useful in the present invention are derived from 2-phenylbenzopyrone of formula (I) or 3-phenylbenzopyrone skeleton of formula (II) (McGraw-Hill encyclopedia of Science and technology).

Flavonoid compounds can be further classified into various groups depending on the oxidation level or substitution pattern of their heterocyclic ring (ring C). Flavonoid compounds useful in the present invention include unsubstituted flavanones, substituted flavanones, unsubstituted flavones, substituted flavones, unsubstituted chalcones, substituted chalcones, unsubstituted isoflavones and substituted isoflavones. As used herein, the term "substituted" means that one or more hydrogen atoms of the skeletal structure described above are independently hydroxyl, C1-C8 alkyl, C1-C4 alkoxyl, O-glycoside or the like or substituents thereof Flavonoid compound replaced with a mixed substituent of. Particularly useful flavonoid compounds in the present invention are selected from the group consisting of substituted flavanones, substituted flavones, substituted chalcones, substituted isoflavones and mixtures thereof.

Flavonoid compounds can be obtained as natural sources, for example as extracts from plants. Examples of suitable flavonoid compounds include flavanones (unsubstituted), flavanonols (3'-hydroxy flavanones), pinosembrins (5,7-dihydroxy flavanones), pinostrobins (5-hydroxyl- 7-methoxy flavanone), liquirigenin (7,4'-dihydroxyflavanone), liqueurine (4'-glucoside-7,4'-dihydroxyflavanone), butine (7, 3 ', 4'-trihydroxy flavanone), sakuranetin (5,4'-dihydroxy-7-methoxy flavanone), saccharin (5-glucoside-5,4'-dihydroxy-7 -Methoxy flavanones), isacuranetine (5,7-dihydroxy-4'-methoxy flavanones), ponsirine (7-rhamnoglucoside-5,7-dihydroxy-4'-methoxy flan Vanone), naringenin (5,7,4'-trihydroxy flavanone), naringin (7-rhamnoglucoside-5,7,4'-trihydroxy flavanone), hesperidin (5,7,3 '-Trihydroxy-4'-methoxy flavanone), Hespe Dean (7-Rhamnoglucoside-5,7,3'-trihydroxy-4'-methoxy flavanone), flavone (unsubstituted), crysin (5,7-hydroxy flavone), toringin (5- Glucoside-5,7-hydroxy flavone), apigenin (5,7,4'-trihydroxy flavone), apiin (7-apio-glucoside-5,7,4'-trihydroxy flavone), Cosmosine (7-glucoside-5,7,4'-trihydroxy flavone), acecetin (5,7, -dihydroxy-4'-methoxy flavone), fortunelin (7-rhamnoglucoside-5, 7, -dihydroxy-4'-methoxy flavone), bicalane (5,6,7-trihydroxy flavone), bicalin (7-glucuronide-5,6,7-trihydroxy flavone) ), Squattlerin (7-glucuronide-5,6,7,4'-tetrahydroxy flavone), diosmethin (5, 7, 3'-trihydroxy-4'-methoxy flavone), Diosmin (7-Rhamnoglucoside-5, 7, 3'-trihydroxy-4'-methoxy fla ), Galangin (3,5,7-trihydroxy flavone), quercetin (3,5,7,3 ', 4'-pentahydroxy flavone), quercitrin (3-rhamnoside-3,5, 7,3 ', 4'-pentahydroxy flavone), rutin (3-rhamnoglucoside-3,5,7,3', 4'-pentahydroxy flavone), raminetin (3,5,3 ', 4 '-Tetrahydroxy-7-methoxy flavone), xanthramine (3-rhamnoside-3,5,3', 4'-tetrahydroxy-7-methoxy flavone), myricetin (5,7,3 ', 4', 5'-pentahydroxy flavoneol), myricithin (3-rhamnoside-5,7,3 ', 4', 5'-pentahydroxy flavoneol), biflavones such as pucu Gettin; Ginkgetin and bilivetin, isoflavones, chalcones, all isomers of the substituted flavones and mixtures thereof are included, but are not limited to these.

Flavonoid compounds useful in the present invention may be synthetic materials derived or modified from naturally supplied materials. Such chemical modifications may result in improved flavonoid compounds or compatibility with other composition components, making them more suitable for skin care compositions. Preferred modified flavonoid compounds are those that are glycosylated, alkylated or acylated from naturally supplied materials.

Particularly useful glycoside flavonoid groups in the present invention are those selected from Formula III:

Wherein R ¹ -R ⁶ are independently selected from the group consisting of H, OH, alkoxy and hydroxyalkoxy, which alkoxy or hydroxyalkoxy groups are branched or unbranched and have 1-18 carbon atoms, Z ¹ is Mono- and oligoglycoside radicals. Z ¹ is preferably selected from the group consisting of hexyl radicals, more preferably rhamnosyl radicals and glucosyl radicals. It is also advantageous to use other hexosyl radicals, for example allocyl, altoxyl, galactosyl, gulosil, iodosil, mannosyl and thalosil. It may also be advantageous for the pentosyl radicals to be used according to the invention.

Another group of glycoside flavonoids particularly useful in the present invention are those selected from Formula IV:

Wherein R ¹¹ -R ¹⁷ are independently selected from the group consisting of H, OH, alkoxy and hydroxyalkoxy, which alkoxy or hydroxyalkoxy groups are branched or unbranched with 1-18 carbon atoms, and Z ² is Mono- and oligoglycoside radicals. Z ² is preferably selected from the group consisting of hexyl radicals, more preferably rhamnosyl radicals and glucosyl radicals. It is also advantageous to use other hexosyl radicals, for example allocyl, altoxyl, galactosyl, gulosil, iodosil, mannosyl and thalosil. It may also be advantageous for the pentosyl radicals to be used according to the invention.

In one particularly preferred embodiment of the present invention, the glycoside flavonoids are selected from the group consisting of glucosyl hesperidin, glucosyl rutin, glucosyl mycitrin, glucosyl isoquarcitrin, glucosyl quictrin, methyl hesperidin and mixtures thereof. These glucoside flavonoid compounds can be obtained from the relevant natural flavonoid compounds by biochemical methods. Glucosyl group (s) may be linked to one or more hydroxides of the original substance.

Representative formulas of glucosyl rutin are as follows:

Representative formulas of glucosyl hesperidin are as follows:

Alkylated flavonoid compounds useful in the present invention are alkoxy or hydroxyalkoxy flavonoids that are typically derived from chemical modifications of common natural flavonoids. Examples of alkylated flavonoid compounds useful in the present invention include the following. These formulas are merely representative and it is possible for the alkyl or hydroxyalkyl groups to be linked to other existing hydroxyl groups.

Representative formulas of Troxerutin (3 ', 4', 7-tri-hydroxyethoxyl-routine) are as follows:

A representative formula of monoxerutin (7-hydroxyethoxyl rutin) is as follows:

Another useful alkylated flavonoid compound, methyl hesperidin, has the formula

Wherein R ²¹ -R ²⁸ are independently selected from the group consisting of H or methyl, and at least one of R ²¹ -R ²⁸ is methyl.

Another group of glycoside flavonoids useful in the present invention is chalcone, which can be obtained by isomerization from any flavanone. Chalcone is very useful in the present invention due to the improvement in solubility which makes it easier to formulate into skin care compositions.

Representative chalcones derived from hesperidin include:

Other representative chalcones derived from hesperidin are:

Commercially available flavonoid compounds include hesperidin, methylhesperidine and rutin available from Alps Pharmaceutical Industry Co. Ltd. (Japan); Glucosyl Hesperidine and Glucosyl, available from Hayashibara Biochemical Laboratories, Inc. (Japan) and Toyo Sugar Refining Co. Ltd. (Japan) Contains routines.

Vitamin B3 Compound

The device of the present invention preferably further comprises a vitamin B3 compound. As described below, the vitamin B3 compound is about 0.01% to about 15%, preferably about 0.1% to about 15%, more preferably, based on the weight of the liquid composition, gel sheet or coating composition of the device of the present invention. Preferably at a level of about 0.5% to about 10%. Vitamin B3 compounds are known to provide themselves with precursors of coenzymes of the family of nicotinamide adenine dinucleotide phosphate (NADP) and the reduced form (NADPH) family, which coenzymes Enhances multiple metabolic enzyme reactions in the phase. In addition, vitamin B3 compounds are known to reduce skin surface moisture loss and excessive skin glycosaminoglycans, which are indicative of skin barrier properties.

It has surprisingly been found that the combination of flavonoid compounds and vitamin B3 compounds results in compositions which provide a synergistic skin treatment effect compared to the single use of any of the active agents above. The skin treatment effect can be seen in particular in terms of skin whitening effect and anti-aging effect.

Without being bound by theory, it is believed that flavonoid compounds enhance the transport of vitamin B3 compounds. Flavonoid compounds have a relatively good affinity with the cell membrane lipid bilayer, while vitamin B3 compounds are less affinity due to their structure, which is generally hydrophilic. By effective transport of the two types of active agent into skin cells, the two types of active agents are believed to provide skin treatment effects through different mechanisms in the dermis, thereby providing synergistic effects to the skin.

Vitamin B ₃ compounds useful in the present invention include, for example, those having the formula:

Wherein R is -CONH ₂ (eg niacinamide) or -CH ₂ OH (eg nicotinyl alcohol); Its derivatives; And salts thereof. Exemplary derivatives of the aforementioned vitamin B ₃ compounds include nicotinic acid esters, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxides and niacinamide N-oxides, including nonvascular dilatable esters of nicotinic acid. . Preferred vitamin B ₃ compounds are niacinamide and tocopherol nicotinate, more preferably niacinamide. In one preferred embodiment, the vitamin B ₃ compound contains a limited amount of salt form and more preferably is substantially free of salts of the vitamin B ₃ compound. Preferably the vitamin B ₃ compound contains less than about 50% of such salts and more preferably is essentially free of salt form. Very useful and commercially available vitamin B ₃ compounds in the present invention include niacinamide USP available from Reilly.

Vitamin B6 Compound

The device of the invention preferably further comprises a vitamin B6 compound. As described below, the vitamin B6 compound is at a level of about 0.001% to about 15%, preferably about 0.01% to about 10% by weight of the composition, more preferably the liquid composition of the device of the present invention. , From about 0.01% to about 5% by weight of the gel sheet, or coating composition. It is known that vitamin B6 compounds provide their own coenzymes for the synthesis of amino acids and nucleic acids, thereby enhancing synergistic actions such as collagen synthesis of skin cells. Improvements in collagen structure are known to provide good skin tone and whitening appearance of the skin.

Surprisingly, it has been found that the use of a vitamin B6 compound in addition to a flavonoid compound and a vitamin B3 compound results in a composition that provides a significant skin treatment effect. The skin treatment effect can be seen in particular in terms of the skin whitening effect and the anti-aging effect.

Without being bound by theory, it is believed that the three types of active agents provide integrated effects on the skin through different mechanisms in the dermis, thereby providing synergistic effects to the skin.

Vitamin B6 compounds useful in the present invention include pyridoxine; Esters of pyridoxine, such as pyridoxine tripanitate, pyridoxine dipalmitate, and pyridoxine dioctanoate; Amines of pyridoxine, for example pyridoxamine; Salts of pyridoxine, for example pyridoxine HCl; And derivatives thereof such as pyridoxamine, pyridoxal, pyridoxal phosphate, and pyridoxic acid. Particularly useful vitamin B6 compounds are selected from the group consisting of pyridoxine, esters of pyridoxine and salts of pyridoxine. Vitamin B6 compounds may be synthetic or natural in origin and may be used as essentially pure compounds or mixtures of compounds (eg, extracts from natural sources or mixtures of synthetic materials). As used herein, "vitamin B6" includes isomers of such and six intervariants. Vitamin B6 compounds useful and commercially available in the present invention are, for example, pyridoxine HCl, available from DSM, under the tradename NIKKOL DP available from Nikko Chemicals Co. Ltd. Pyridoxine dipalmitate and pyridoxine dioctanoate under the trade name Nicole DK.

Forms of Preformed Substrates and Devices

The device of the present invention is based on a preformed substrate capable of maintaining structure and properties on the skin surface for at least the time the product is designed to treat the skin. Generally speaking, the substrate-based skin care device remains intact in the skin for at least 5 minutes. In general, the substrate type skin care device according to the present invention is sized such that the area of each surface is from about 0.25 cm 2 to about 1,000 cm 2, preferably from about 1 cm 2 to about 300 cm 2. Surface area refers to the area of a flat plane with the same boundaries as the surface, ie a plane ignoring any surface texture present. Substrate skin care devices of the present invention are, for example, square, round, semicircular, rectangular, oval, annular, crescent, teardrop or other more complex shapes-such as eye area, eyelid, nose, mouth area, forehead, Or may be a composite shape of the above type to cover an area such as the chin, the entire contour of the face, the neck, or a combination thereof.

The preformed substrate may be provided in various forms and compositions.

In one preferred embodiment, the device is in the form of what is commonly referred to as a treatment mask, wherein the substrate is water insoluble and the remainder of the device is formed of a liquid composition, which liquid composition is based on the weight of the water insoluble substrate 100 % To 2,000%. In this embodiment, the liquid composition and the substrate are substantially inert with respect to each other. For convenience, this embodiment is referred to hereinafter as "mask", and the terms "water insoluble substrate" and "liquid composition" herein specifically relate to mask embodiment.

In another preferred embodiment, the apparatus is usually in the form of what is called a patch or gel, wherein the substrate is a gel sheet comprising a gelling agent and a hydrophilic solvent for the gelling agent, the gel sheet comprising a flavonoid compound. For convenience, this embodiment is referred to hereinafter as "gel sheet" and the terms "coating composition" and "gelling agent" herein specifically relate to gel sheet embodiments.

In gel sheet embodiments, the substrate itself releases flavonoid compounds when in contact with the skin. In a particularly preferred embodiment, the device further comprises a separate coating composition in addition to the gel sheet, which coating composition also contains a flavonoid compound. The coating composition may be included in the same package as the gel sheet to reach equilibrium in the package. A separate coating composition is clearly meant to be applied to the gel sheet as another composition, in particular having a different chemical composition which is prepared separately from the gel sheet before and after or at the same time as the gel sheet and laid as a separate layer. The coating composition allows for more efficient delivery of flavonoid compounds and other skin active agents to the skin, resulting in greater formulation flexibility. The coating composition preferably contains a flavonoid compound, ie contains at least one skin active agent in common. In this way, the coating composition can quickly provide the skin active agent to the target area, while the gel sheet can act as a reservoir of skin active agent or prevent the gel sheet from absorbing flavonoid compounds and other skin active agents from the coating composition. Can be.

Gel sheet embodiments may further comprise a water insoluble substrate, such as a substrate in the form of a film, for the addition of strength or occlusivity.

Liquid medium

The device of the present invention comprises a liquid medium that is liquid at 25 ° C. to deliver flavonoid compounds and other optional skin active agents through the substrate to the skin, regardless of the form of the composition. The liquid medium is typically water or an aqueous solution. When a preferred device of the present invention comprising water is applied to a given area of skin, the temperature of the given skin surface is significantly lowered due to water. However, in the present invention, the presence of a flavonoid compound in the composition alleviates the temperature drop on the skin surface. Without being bound by theory, it is believed that such relaxation of the temperature drop is due to the ability of the flavonoid compounds to improve circulation. Mitigation of the temperature drop is advantageous in that the penetration of the active agent through the skin is slowed down as the temperature of the skin surface decreases.

For mask embodiments, a liquid medium is used as the carrier of the liquid composition. For gel sheet embodiments, the liquid medium is used as a hydrophilic solvent for the gelling agent and also as a carrier for the coating composition.

The level and chemical species of the liquid medium are selected depending on the compatibility with other components and other desired features of the product. Liquid media useful in the present invention include water and aqueous solutions of lower alkyl alcohols. Lower alkyl alcohols useful in the present invention are monohydric alcohols having 1 to 6 carbons, more preferably ethanol. Preferably deionized water is used. Natural waters containing mineral cations may also be used, depending on the desired product properties.

The liquid medium preferably comprises a water soluble humectant to provide the skin with a moisturizing effect. Water-soluble wetting agents useful in the present invention are glycerin, diglycerin, propylene glycol, dipropylene glycol, butylene glycol, hexylene glycol, sorbitol, ethoxylated glucose, 1,2-hexane diol, hexanetriol, erythritol, trehalose Polyhydric alcohols such as xylitol, maltitol, maltose, glucose, fructose, sodium chondroitin sulfate, sodium hyaluronate, sodium adenosine phosphate, sodium lactate, pyrrolidone carbonate, glucosamine, cyclodextrins, and mixtures thereof.

Water soluble wetting agents useful in the present invention are also water soluble alkoxylation ratios such as polyethylene glycol and polypropylene glycol having a molecular weight up to about 1,000, such as those having CTFA names PEG-200, PEG-400, PEG-600, PEG-1000 and mixtures thereof. Ionic polymers.

When used as a hydrophilic solvent of the gelling agent of the gel sheet, the liquid medium is chosen such that the gel phase is made with the gelling agent at room temperature. The amount and type of solvent is determined to provide a stable gelling agent in terms of the desired mechanical properties, in particular gel strength and flexibility, and in terms of the desired properties of the product obtained. Preferably, the solvent also acts as a plasticizer or softener for gel sheets. The gel sheet preferably comprises about 10% to about 99.5% water, more preferably about 20% to about 95%, even more preferably about 30% to about 90% water. More preferably, the gel sheet further comprises about 1.0% to about 50%, preferably about 5% to about 45%, more preferably about 10% to about 40% polyhydric alcohol.

Water Insoluble Substrate

The water-insoluble substrate that may be used in the present invention is a tool or vehicle for delivering a liquid composition to the skin in a mask embodiment of the present invention. "Water insoluble" means that the substrate does not dissolve in water or readily disintegrate when immersed in water.

A wide variety of materials can be used as the water insoluble substrate. The following non-limiting properties are preferred: (i) sufficient wet strength for use, (ii) sufficient thickness and (iii) appropriate size.

Non-limiting examples of suitable water insoluble substrates that meet the criteria include nonwoven substrates, woven substrates, hydroentangled substrates, air entrangled substrates, natural sponges, synthetic sponges, polymeric mesh meshes, and the like. Include. Preferred embodiments use nonwoven substrates because they are economical and readily available in a variety of materials. By "nonwoven" is meant that the layer is not woven from cloth, but rather consists of fibers formed of a sheet, mat or pad layer.

The water insoluble substrate may be made of various natural and synthetic materials. Non-limiting examples of natural materials useful in the present invention include the following: silk fibers; Keratin fibers, such as wool fibers and camel hair fibers; And cellulose fibers such as wood pulp fibers, cotton fibers, hemp fibers, jute fibers and flax fibers. Non-limiting examples of synthetic materials useful in the present invention include: acetate fibers; Acrylic fibers; Cellulose ester fibers; Polyamide fibers; Polyester fibers such as polyethylene terephthalate fibers; Polyolefin fibers such as polypropylene fibers and polyethylene fibers; Polyvinyl alcohol fibers; Rayon fibers; And polyurethane foam.

Water insoluble substrates useful in the present invention can also be obtained from a wide variety of sources. Non-limiting examples of suitable nonwoven substrates useful in the present invention include: WALKISOFT®, a cellulose substrate available from Walkisoft U.S.A .; NOVONET® 149-801, a substrate comprising about 69% rayon, about 25% polypropylene, and about 6% cotton, available from Veratec, Inc., Walpole, Massachusetts. And 149-191; KEYBAK® 951V and 1368, a substrate comprising about 75% rayon and about 25% acrylic fibers available from PGI / Chicopee, Dayton, NJ; The outer layers available from Daiwabo KK are each made of a combination of rayon and polyester and RMT-90, a three-layered substrate with a pulp layer as the inner layer, and three with a combination PP layer as the inner layers of the rayon. RFP-90, which is a layer substrate, R-80, which is a single layer substrate comprising 100% rayon.

The water insoluble substrate is advantageous for the provision of a device corresponding to the shape of the face. In one highly preferred embodiment, the water-insoluble substrate is configured to cover substantially the entire facial skin area while opening the eye and nostril areas. In another very preferred embodiment, the water-insoluble substrate is configured to substantially cover the entire area of the face skin, the first piece covering the upper area of the face, ie the nose and the upper part and the lower area of the face, ie the upper lip, cheek And two pieces of second pieces covering the bottom. In another preferred embodiment, the water-insoluble substrate is configured to match a particular area of face, such as the nose, cheekbones, chin, forehead, neck, or a combination thereof. In another very preferred embodiment, the water insoluble substrate is configured to have ears, pulls or rings to aid in the placement and / or removal of the composition on the skin.

The water-insoluble substrate is sufficiently flexible to easily fit along the skin when wetted with a liquid composition, and is strong enough to not easily tear or break upon use. Preferably, the water insoluble substrate has a thickness from about 100 μm to about 1 cm, more preferably from about 300 μm to about 3 mm, depending on the material of manufacture of the water insoluble substrate and the use and characteristics of the product.

Particularly useful water-insoluble base materials in the present invention include those that have hydrophilicity and can absorb larger amounts of liquid compositions. The water insoluble substrate can be made only of hydrophilic materials or a mixture of hydrophilic and hydrophobic materials. The water-insoluble substrate of the present invention may consist of a single layer or multiple layers. In one preferred embodiment, the water-insoluble substrate is at least partially made of a hydrophilic material selected from cotton, pulp, rayon and mixtures thereof. By partial it is meant to cover the following situations: when one layer of hydrophilic material is used for a single layer substrate; At least one layer of hydrophilic material is used for the multilayer substrate; When one layer of a mixture of hydrophilic and other materials is used for a single layer substrate; And at least one layer of a mixture of hydrophilic and other materials is used for the multilayer substrate.

When the water-insoluble substrate consists of multiple layers, it is preferable that at least the layer facing the skin is hydrophilic and can absorb a greater amount of the liquid composition. When the water-insoluble substrate consists of multiple layers, the substrate may comprise films and other extrafibrous materials. In one embodiment, the water insoluble substrate may also be laminated with a polymeric film, coated on the substrate, or heat sealed on the substrate. The resulting substrate with the laminated polymer film, coating or heat seal includes a closed side on one side of the substrate that is not facing the face and a skin facing side that is placed on the skin surface. By having the substrate have a closed side, the substrate has a low air permeability. "Low air permeability" means that the surface of the substrate with the film, coating, or heat seal allows only very little air to enter the substrate such that only a very small vapor escapes from the substrate. Preferably, the air permeability is less than about 5 mg / cm 2 / min.

Water insoluble substrates comprising a closed side significantly increase the penetration of the skin active agent into the skin as compared to a water insoluble substrate without a closed side. In addition, the substrate-type skin care device of the present invention uses the tension of water rather than a strong adhesive on the skin facing surface to adhere to the skin surface. As used by the present invention, the absence of a strong adhesive between the substrate and the skin surface eliminates the physical barrier resulting from the strong adhesive and promotes penetration of oily ingredients and other skin active agents. The environment created between the skin and the water insoluble substrate promotes penetration of the skin actives into the skin.

Suitable polymer films include polyethylene, polypropylene, polyethylene terephthalate, polyamide, polyester, nylon, mixtures thereof, or any other cosmetically acceptable polymer film. Suitable coatings impart low air permeability to the water insoluble substrate and include any material known in the art that is cosmetically acceptable. Heat sealing of the water-insoluble substrate may be accomplished by any method known in the art for imparting low air permeability to the substrate.

In one embodiment, the water-insoluble substrate comprises a layer having a gradient of hydrophilic properties, that is, a hydrophobic material and a gradient of the distribution of hydrophilic material. In such a water-insoluble substrate, it is preferable that the substrate is distributed with a large amount of hydrophilic material on the opposite surface and a large amount of hydrophobic material on the opposite surface. This structure allows moisture to migrate from the hydrophobic side of the substrate to the hydrophilic skin facing side of the substrate and then to the skin surface. Such water-insoluble substrates may be single layer substrates, may further comprise other layers, or may be laminated with a polymer film.

Liquid composition

The liquid composition of the mask embodiment of the present invention allows the water insoluble substrate described below to be impregnated, or coated with or otherwise contacted with the water insoluble substrate.

The liquid composition of the present invention

(a) a water soluble thickener that provides a liquid composition with a viscosity of about 10 mPa / s to about 600,000 mPa / s; And

(b) contains water.

The amount of liquid composition associated with any of the compositions will vary depending on the desired characteristics of the device of the finished mask embodiment, but should be at least sufficient to deliver the flavonoid compound to the skin surface. Preferably, the water insoluble substrate remains saturated with the liquid composition during the interval between saturation of the water insoluble substrate with the liquid composition and application. For the desired purpose, the liquid composition will preferably exhibit from about 100% to about 2,000%, more preferably from about 200% to about 1,500% by weight of the water-insoluble substrate. The amount of liquid composition to be used will depend on the absorption capacity of the water-insoluble substrate and the desired properties of the composition.

The liquid compositions used in the masks of the present invention have a viscosity, as measured by a Brookfield digital viscometer, model DV-II + version 3.2, according to the operating instructions set forth in manual number M / 92-161-H895. Is from about 1000 mPa / s to about 600,000 mPa / s, preferably from about 2000 mPa / s to about 300,000 mPa / s, more preferably from about 3000 mPa / s to about 100,000 mPa / s. Such viscosity is believed to be suitable for suspending the skin tone modifier in a liquid composition in an effective manner and also for effectively depositing skin tone modifiers and other effect agents on the skin.

Gelling agent

Gel sheet embodiments of the present invention include a gelling agent that provides a solid structure that is stable at normal storage temperatures. Mixtures of gelling agents can be used. The type and amount of gelling agent included in the gel sheet is selected according to the desired properties and purposes of the product according to the characteristics of the gelling agent. In general, the more gelling agent used, the more rigid the gel sheet will be. Many kinds of gelling agents are known in the art, including polymeric gelants and particulate gelants such as various kinds of clay or other silicate based materials. Polymeric gelling agents which combine with water to form a three dimensional gel network are very preferred in the present invention. The gel sheet preferably comprises about 0.5% to about 20%, more preferably about 1% to about 10% of a gelling agent.

The gelling agent in the present invention may be water soluble or water insoluble and may be selected according to the solvent. If the solvent is water or aqueous, preferably the gelling agent is water soluble. Silicone materials, for example water insoluble polymeric gelants such as organopolysiloxane resins or block copolymer thermoplastic elastomers, can be used in suitable solvents.

The water soluble polymeric gelant for use in the present invention is selected from synthetic or natural polymers and mixtures thereof. Preferred polymers for use in the present invention are natural polymers including gelatin, polysaccharides and mixtures thereof. Polysaccharides are preferred. As used herein, the term "polysaccharide" refers to a polymer of linear, branched or crosslinked monosaccharide units of natural or synthetic nature that, when dispersed at low concentrations in water, expand to enrich the aqueous phase.

The polysaccharide for use in the gel sheet of the present invention is preferably red algal polysaccharide; Glucomannan; Galactomannan; Fermented polysaccharides or derivatives thereof; Brown algae polysaccharides; Extracts of marine invertebrates; Starch or derivatives thereof; Natural fruit extracts; Plant fiber derivatives; Kelp; Natural plant exudate; Resin gum; Or mixtures thereof. The total polysaccharide level is adjusted such that the skin active agent of the gel sheet comprising the flavonoid compound diffuses without tightly binding into the gel reticular.

When gelatin is used in the gel sheet of the present invention, high molecular weight gelatin is combined with low molecular weight gelatin to control solubility. Gelatin having a low molecular weight of 20,000 or less has a weaker gelling ability when used as a single gelling agent.

Brown algae polysaccharides are isolated by extraction from various species of Phaebophyceae. Brown algae polysaccharides suitable for use in the present invention include algin, alginic acid, ammonium alginate, calcium alginate, potassium alginate, sodium alginate, propylene glycol alginate and mixtures thereof.

Red algae polysaccharides are isolated from marine plant species belonging to the Rhodophyceae. Red algae polysaccharides provide mechanical strength to the gel sheet. Red algae polysaccharides suitable for use in the present invention are commercially available from TIC Gums (Belcamp, MD) as "Agar Agar 100" or "Agar Agar 150" or Gumix International Inc. Agar agar flake, commercially available from Gumix International Inc. (Fort Lee, NJ) and derived from a variety of Gelidium plant species or closely related red algae. Agar known in the industry under the (CTFA) trade name; Agarose from FMC (Philadelphia, Penn.) As "Sea Plaque®" and from Sigma-Aldrich Co. Ltd. (Full, UK). Agarose, available commercially as Type 1-b ";" Gelcarin® LA "," Seakem® 3 / LCM ", or" PM "from Philadelphia, Pa. Lambda-, Iota- and water extracts, available from various members of the family Asteraceae or Sticky Genus, commercially available under the trademark (CTFA) under the trade name CTSC "and available under the Viscarin® XLV" Carrageenan, including the kappa- moiety; and Percelanan, commercially available from Gum Technology Corporation (Tucson, Arizona) and Continental Colloids Inc. (Chicago, Illinois). furcellaran), or mixtures thereof Preferably, the red algae polysaccharides for use in the present invention are selected from agar, agarose, kappa-carrageenan and percellaran, or mixtures thereof.

Glucomannan is essentially a polysaccharide comprising the backbone of linear glucose and mannose residues. Glucomannan has a short side chain attached to the linear backbone and acetyl groups are randomly present at the C-6 position of the sugar unit. Acetyl groups are generally found, one per six sugar units, one per twenty sugar units. Suitable glucomannans or derivatives thereof for use in the present invention have a ratio of mannose to glucose of about 0.2 to about 3. Preferred glucomannan for use in the present invention is a common name for a powder formed by pulverizing bulbs of the Amorphophallus konjac plant (elephant yam), from FMC (Philadelphia, PA). Konjac mannan available under the trade name “Nutricol Konjac Flower”; And deacetylated konjac mannan; Or mixtures thereof.

Galactomannan is a vegetable storage polysaccharide produced in the endodermal cells of many legumes (Leguminosae) seeds. The generic term galactomannan includes all polysaccharides composed of galactose and mannose residues. Galactomannans comprise a linear backbone of (1 → 4) -binding β-D-mannopyranosyl units. To this ring, the isolated galactopyranose residue is attached as a branch by an α- (1,6) -glucoside bond. Galactomannans may also contain small amounts of other sugar residues. Galactomannans suitable for use in the present invention include phenogrig gums; Lucern; clover; Locust bean gum known in the industry under the (CTFA) trade name as a carob bean gum sold, eg, as "Seagul L" from FMC (Philadelphia, Pennsylvania); Tara gum sold from Starlight Products (Luen, France) or Bungee Foods (Atlanta, Georgia, USA); From TIC Gums (Belcamp, MD) to "Burtonite V7E", from LongFran (Marietta, GA) to "Jaguar C", or from Aqualon (Wilmington, DE) to "Supercol" Guar gum derived from basal endosperm of the commercially available guar (Cyamopsis tetragonolobus); And Cassia gum, commercially available from Starlight Products (Lueng, France), or mixtures thereof. Preferably, the galactomannan for use in the present invention has an average of one to about 5 mannosyl units substituted with (1 → 6) -binding-α-D-galactopyranosyl units, and guar gum. , Locust bean gum, cassia gum, or mixtures thereof.

Fermented polysaccharides are polysaccharides produced commercially by fermentation of microorganisms in a medium containing carbon and nitrogen sources, buffers and trace elements. Fermented polysaccharides or derivatives thereof suitable for use in the present invention are commercially available as "Kelcogel" from Kelco (San Diego, Calif.) And are produced by pure culture fermentation of carbohydrates by Pseudomonas elodea. Is a high molecular weight heteropolysaccharide gum, a gellan gum known in the industry as the gum gellan under the (CTFA) trade name, and "Keltrol CG 1000 / BT / F / GM / RD from Calgon (Pittsburgh, Pa.) / SF / T / TF "or by Xanthomonas campestris, known as xanthan under the (CTFA) trade name in the industry, available as" Kelzan "from Kelco (San Diego, Calif.) Xanthan gum, natto gum, and pullulan, which are high molecular weight heteropolysaccharide gums produced by pure culture fermentation of carbohydrates; "Sephadex" from rhamsan gum, curdlan, succinoglycans, welan gum, Pharmacia Fine Chemicals (Piscataway, NJ) Dextran, commercially available as (Sephadex) G-25 and its derivatives, bacteriostatic gum sold as "Amigel" from Alban Muller International (Montrey, France) and mixtures thereof Preferred fermented polysaccharides or derivatives thereof are selected from gellan gum and xanthan gum or mixtures thereof More preferably, the fermented polysaccharides or derivatives thereof are xanthan gum.

Extracts of marine invertebrates may also be used. Marine invertebrates, in particular polysaccharides derived from the exoskeleton of such invertebrates, consist mainly of N-acetyl-D-glucosamine residues. Examples of such polysaccharides suitable for use in the present invention include, for example, chitosan, commercially available as "Marine Dew" from Ajinomoto (Tanek, NJ); And hydroxypropyl chitosan and derivatives commercially available as "HPCH Liquid" from Ichimaru Pharcos (Yamagata-gun, Gifu, Japan); Or mixtures thereof.

Starch is a polysaccharide composed of two glucose polymers, amylose and amylopectin, in varying proportions. Suitable materials for use in the present invention include starches, amylopectin, and dextrins sold as "Nadex 360" from National Starch (Bridgewater, NJ), and derivatives or mixtures thereof. do. Examples of natural fruit extracts suitable for use in the present invention include pectin, arabian and mixtures thereof. An example of a plant fiber derivative suitable for use in the present invention is cellulose. Polysaccharides obtained from natural plant exudates suitable for use in the present invention include karaya, tragacanth, arabic, tamarind, and ghatty gum, or mixtures thereof. Examples of resin gums suitable for use in the present invention include shellac gum and damar gum, copal gum and rosin gum, or mixtures thereof, obtained from resinous secretions of Lacifer (Tachardia) lacca.

In addition, natural and synthetic polymerized gelling agents that form gels in combination with other materials may also be used as gelling agents in combination with other thermoforming gelling agents, as long as gelling can occur simultaneously. They can be chemically crosslinked. Some gelling agents form gels in combination with sugars, alcohols, or substances such as monovalent or polyvalent salts. Monovalent or polyvalent salts may also serve as gel enhancers that provide additional strength to the gel sheets of the present invention. Suitable cations for such salts may be selected from potassium, sodium, ammonium, zinc, aluminum, calcium, and magnesium ions, or mixtures thereof. Suitable anions associated with the aforementioned cations may be selected from chlorides, citrates, sulfates, carbonates, borate salts, and phosphate anions, or mixtures thereof.

Physical crosslinking refers to a polymer having a crosslink having physical properties with regions having high crystallinity or regions having high glass transition temperature that are not chemical covalent bonds. Such crosslinked polymers may also be used. Preferably, the polymer is chemically thermally crosslinked. In addition, once chemical crosslinks are formed in the system, multiple functional crosslinkers and / or free radical initiators may be present in the premix to initiate crosslinking upon irradiation.

Preferably, the gel sheet of the present invention comprises a mixture of water soluble polymeric gelling agents of natural origin. Preferred water-soluble polymerized gelling agent mixtures in the present invention may comprise polysaccharides and nonionic water soluble polymers, or may comprise two polysaccharides. More preferably, the water soluble polymeric gel former is a polysaccharide mixture, the polysaccharide mixture comprising (1) at least one red algae polysaccharide, brown algae polysaccharide, or mixtures thereof, and (2) at least one fermented polysaccharide, galactomannan, glucomannan , Natural plant exudate, or natural fruit extracts and derivatives or mixtures thereof. Even more preferably, the water soluble polymeric gel former of the gel sheet of the present invention comprises (1) at least one red algae polysaccharide; And (2) at least one fermented polysaccharide, glucomannan, or galactomannan; And polysaccharide mixtures comprising derivatives or mixtures thereof.

In a preferred embodiment, the water soluble polymeric gel former of the present invention is a polysaccharide mixture comprising red algae polysaccharides and glucomannan or galactomannan. The ratio of red algae polysaccharide to glucomannan or galactomannan in the polysaccharide mixture is preferably from about 20: 1 to about 1: 5, more preferably from about 10: 1 to about 1: 2. Without being bound by theory, it is believed that the gel compositions of the present invention form a three-dimensional network or matrix that binds or encapsulates the other components of the composition.

Water soluble thickener

The liquid composition of the mask embodiment includes a water soluble thickener. Water soluble thickeners may also be used for gel sheets and / or coating compositions. The water soluble thickener in the present invention is a water soluble or water miscible polymer, has the ability to increase the viscosity of the composition and is compatible with the other ingredients used in the composition. The water soluble thickener has a liquid composition of the composition of about 10 mPa / s to about 600,000 mPa / s, preferably about 10 mPa / s to about 100,000 mPa / s, more preferably about 100 mPa / s to about 30,000 mPa / It is chosen to have a desired viscosity of s. The water soluble thickener is preferably contained at a level of about 0.01% to about 5%, more preferably about 0.1% to about 2% by weight of the liquid composition.

Water soluble thickeners useful in the present invention include anionic polymers and nonionic polymers. Water-soluble thickeners useful in the present invention are, for example, acrylic polymers, polyalkylene glycol polymers having molecular weights greater than about 10,000, derivatives thereof such as cellulose and hydroxyethyl cellulose, polyvinylpyrrolidone, polyvinyl alcohol, guar rubber And rubber such as xanthan rubber, carrageenan, pectin, agar, quince seed (Cydonia oblonga Mill), starch (rice, corn, potato, wheat), algae colloid (seaweed extract), dextran, stone Cynoglucan, pulleran, carboxymethyl starch, methylhydroxypropyl starch, sodium alginate, and alginic acid propylene glycol esters. Neutralizers may also be included to neutralize the anionic thickeners disclosed above. Non-limiting examples of such neutralizers include sodium hydroxide, potassium hydroxide, ammonium hydroxide, monoethanolamine, diethanolamine, triethanolamine, diisopropanolamine, aminomethylpropanol, tromethamine, tetrahydroxypropyl ethylenediamine and their Mixtures.

Among the above polymers, those which reduce undesirable polymer flakes when the emulsified liquid composition is dried on the skin are very preferred. Such highly preferred polymers include, for example, acrylic polymers. Acrylic polymers useful in the present invention include those comprising monomers selected from the group consisting of acrylic acid, salts of acrylic acid, derivatives of acrylic acid, methacrylic acid, salts of methacrylic acid, derivatives of methacrylic acid, and mixtures thereof. The derivatives include, for example, alkyl acrylates, acrylamides, alkyl methacrylates and methacrylamides. Such acrylic polymers include, for example, crosslinked acrylic acid polymers having a CTFA name carbomer, sodium polyacrylates, polyacrylamides, and acrylic acid / alkyl acrylates having a CTFA name acrylate / C10-30 alkyl acrylate crosspolymer Copolymers. Commercially available acrylic polymers that are very useful in the present invention are, for example, polyacrylamides with the name Sepiegel 305 available from SEPPIC Inc., and are in combination with B.F. Acrylate / C10- with trade names available from BF Goodrich Company under the names Pemulen TR-1, Pemulen TR-2, Carbopol 1342, Carbopol 1382, and Carbopol ETD 2020. 30 alkyl acrylate crosspolymers.

Oily ingredients

The liquid composition, gel sheet or coating composition of the present invention may further comprise an oily component. Oily ingredients useful in the present invention can deliver skin conditioning effects such as smoothness and softness to the skin. Oily components useful in the present invention are, for example, C _7-40 straight and branched chain hydrocarbons such as fatty alcohols, silicone oils, mineral oils, petrolatum, isohexadecane, C _1-30 alcohol esters such as isopropyl isostearate, Glycerides, alkylene glycol esters, propoxylated and ethoxylated derivatives, sugar esters such as sucrose polycottonside, vegetable oils such as coconut oil, hydrogenated vegetable oils, animal fats and oils, C ₄ of polypropylene glycol _-20 alkyl ethers, C _1-20 carboxylic acid esters of polypropylene glycol, and di-C _8-30 alkyl ethers. Hydrophobic nonionic surfactants which are water insoluble and have an HLB value of less than 10 can be used as oily components. Hydrophobic nonionic surfactants useful in the present invention are, for example, cetearyl glucosides, steareth-2, laureth-4, sucrose cocate, sorbitan monoisostearate, sorbitan diisostearate, sorbent High performance sesquiisostearate, sorbitan monooleate, sorbitan dioleate, sorbitan sesquioleate, glyceryl monoisostearate, glyceryl diisostearate, glyceryl sesquiisostearate, glycerol Reel monooleate, glyceryl dioleate, glyceryl sesquioleate, diglyceryl diisostearate, diglyceryl dioleate, diglycerine monoisostearyl ether, diglycerine diisostearyl ether, and Its mixture.

Of these oily ingredients, fatty alcohols are highly desirable because they can form gel networks as surfactants that not only provide skin conditioning effects but also provide on-conditioning effects such as increased viscosity, phase stability and slippery feel. Because there is. Fatty alcohols useful in the present invention are saturated linear or branched fatty alcohols selected from the group consisting of saturated linear or branched C _12-30 fatty alcohols, saturated linear or branched C _12-30 diols, and mixtures thereof. . Preferred fatty alcohols are cetyl alcohol, stearyl alcohol, and mixtures thereof.

Hydrophilic surfactant

The liquid composition, gel sheet or coating composition of the present invention may further comprise a hydrophilic surfactant for the dispersion or emulsification of the oil component. Hydrophilic surfactants useful in the present invention are water soluble and preferably have an HLB value greater than 10. Hydrophilic surfactants useful in the present invention include, for example, any cosmetically acceptable surfactants, i.e., nonionic surfactants, cationic surfactants, anionic surfactants, zwitterionic surfactants, amphoteric surfactants and mixtures thereof. It includes. Of these, preferred in the present invention are cosmetically acceptable nonionic surfactants in view of reduced skin irritation and conditioning effects.

Hydrophilic nonionic surfactants useful in the present invention are, for example, PEG-100 stearate, polysorbate-20, polysorbate-60, ceteareth-21, isosetetsu-20 and olece-20, lau Let-23, ceteareth-12, steareth-100, PEG 40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, and mixtures thereof.

Additional skin active agents

The liquid composition, gel sheet or coating composition of the present invention may further comprise a safe and effective amount of additional skin active agent. Skin active agents useful in the present invention are skin whitening agents, anti acne agents, emollients, nonsteroidal anti-inflammatory agents, local anesthetics, artificial tanning agents, fungicides, antimicrobial and antifungal actives, skin calming agents, sunscreening agents, skin barrier repair agents, anti-wrinkle agents, Anti-skin atrophy actives, lipids, sebum inhibitors, sebum inhibitors, skin sensates, protease inhibitors, skin tension agents, anti-itch agents, hair growth inhibitors, dermabrasion enzyme enhancers, anti-glycosylating agents, and mixtures thereof. When included, the compositions of the present invention contain from about 0.001% to about 30%, preferably from about 0.001% to about 10% of additional skin active agent by weight of the liquid composition, gel sheet or coating composition.

The type and amount of skin active agent is chosen such that the inclusion of a particular agent does not affect the stability of the composition.

Skin lightening agents useful in the present invention refer to active ingredients that improve hyperpigmentation as compared to prior treatment. Skin lightening agents useful in the present invention include ascorbic acid compounds, azelaic acid, butyl hydroxyanisole, gallic acid and derivatives thereof, glycyrginic acid, hydroquinone, kojic acid, arbutin, audi extracts and mixtures thereof. The combination of skin lightening agents is believed to be advantageous in that they may provide skin whitening effects through different mechanisms.

Ascorbic acid compounds useful in the present invention include L-form ascorbic acid itself, ascorbic acid salts and derivatives thereof. Ascorbic acid salts useful in the present invention include sodium, potassium, lithium, calcium, magnesium, barium, ammonium and protamine salts. Ascorbic acid derivatives useful in the present invention include, for example, esters of ascorbic acid and ester salts of ascorbic acid. Particularly preferred ascorbic acid compounds are esters of ascorbic acid and glucose, 2-oD-glucopyranosyl-L-ascorbic acid, and metal salts thereof, usually referred to as L-ascorbic acid 2-glucoside or ascorbyl glucoside, and sodium ascorbyl phosphate L-ascorbic acid phosphate ester salts such as potassium ascorbyl phosphate, magnesium ascorbyl phosphate and calcium ascorbyl phosphate. Commercially available ascorbic compounds are available from Magnesium Ascorbyl Phosphate, available from Showa Denko, 2-oD-glucopyranosyl-L-ascorbic acid and DSM available from Hayashibara, STAY) sodium L-ascorbyl phosphate which is C50.

Other hydrophobic skin lightening agents useful herein are ascorbyl tetraisopalmitate (e.g., VC-IP available from Nico Chemical), ascorbyl palmitate (for example available from DSM), As Ascorbic acid derivatives such as corbyl dipalmitate (eg, Nicol CP available from Nico Chemical); Undecylenoyl phenyl alanine (eg, SEPIWHITE MSH available from Sepic); Octadecenedioic acid (eg, ALATONE DIOIC DCA available from Uniquema); Oenothera biennis seed extract, and pyrus malus (apple) fruit extract, and mixtures thereof.

Other skin active agents useful in the present invention include panthenol, benzoyl peroxide, 3-hydroxybenzoic acid, farnesol, phytantriol, glycolic acid, lactic acid, 4-hydroxybenzoic acid, acetyl salicylic acid, 2-hydroxybutanoic acid, 2 -Hydroxypentanoic acid, 2-hydroxyhexanoic acid, cis-retinoic acid, trans-retinoic acid, retinol, retinyl esters (e.g. retinyl propionate), phytic acid, N-acetyl-L-cysteine, lipoic acid , Tocopherol and esters thereof (e.g. tocopheryl acetate), azelaic acid, arachidonic acid, tetracycline, ibuprofen, naproxen, ketoprofen, hydrocortisone, acetominophene, resorcinol, phenoxyethanol, phenoxypropanol, Phenoxyisopropanol, 2,4,4'-trichloro-2'-hydroxy diphenyl ether, 3,4,4'-trichlorocarvanide, octopyrox, lidocaine hydrochloride, clotrimazole, Include those selected from the sol to Kona, ketoconazole, neomycin sulfate, theophylline, and mixtures thereof.

Additional ingredients

The devices of the present invention are commonly used in topical products, for example, to provide a composition or skin with aesthetic or functional effects, such as sensory, therapeutic, or prophylactic effects relating to appearance, odor, or feel. It may further contain additional ingredients such as those to be used. It should be understood that the necessary materials above may themselves provide such effects.

Examples of suitable topical ingredients include anticellulite, antioxidants, radical scavengers, chelating agents, vitamins and derivatives thereof, abrasives, other oil absorbents, astringents, dyes, essential oils, perfumes, structuring agents, emulsifiers, solubilizers, anticaking agents , Antifoams, binders, buffers, bulking agents, denaturants, pH adjusters, propellants, reducing agents, metal ion sequestrants, cosmetic biocides, and preservatives.

How to use

The skin care device of the present invention is suitable for topical application to the skin of the human body, in particular facial skin. The use of the device of the invention enhances the penetration of the components contained in the device, in particular by the specific skin active agent contained in the device. The device of the present invention is particularly advantageous for the delivery of flavonoid compounds and other skin active agents such that the skin is exposed to abundant amounts of such agents over a long period of time. It is believed that the use of preformed substrates as a means of delivery over long periods of time results in better distribution and deposition of such formulations and better penetration of percutaneously deliverable formulations. In addition, the device of the present invention is also believed to provide the user with an emotional effect such as a refreshing and comfortable feeling in use. The device of the present invention is applied to the skin for about 5 to about 45 minutes, preferably about 15 to about 45 minutes.

Since the device of the present invention is easily dried by exposure to normal atmospheric conditions, the device should be placed in a hermetically sealed package during storage.

The following examples illustrate and illustrate the invention in more detail within the scope of the invention. As many variations are possible without departing from the spirit and scope of the invention, this embodiment is provided for illustrative purposes only and should not be construed as a limitation of the invention. Where applicable, components are identified by chemical or CTFA name or alternatively as defined below.

Example 1-12

Examples 1-12 are mask embodiments using 3.0 g of substrate RFP-90, available from Daiwabo, cut and molded as a water-insoluble substrate, each of 20-30 g specified in Tables 1 and 2 below. Wet with a liquid composition.

Definition of ingredients

* 1 Glucosyl Hesperidin: Alpha-Ghesperidin PS-CC available from Toyo Sugar Refining.

* 2 Glucosyl Routine: Alpha-Grutin available from Toyo Sugar Refining

* 3 Niacinamide: Niacinamide USP available from DSM

* 4 Pyridoxine Dipalmitate: Nicole DP available from Nico Chemicals

* 5 Isopropyl isostearate: Schercemol 318 available from Scher Chemicals Inc.

* 6 Sucrose Polycotton Date: available from Kobo Products Inc.

* 7 Isohexadecane: Permethyl 101A available from Bayer Corp.

* 8 Dimethicone and Dimethiconol: Dow corning Q2-1503 fluid available from Dow Chemicals.

* 9 PEG-100 Stearate: Myrj 59P available from Uniqema

* 10 cetearyl glucoside: Emulgade PL 68/50 available from Cognis

* 11 polyacrylamide: Sepigel 305 available from Sepik Inc.

* 12 acrylate / C10-30 alkyl acrylate crosspolymer: b. F. Pemulen TR-2 available from Goodrich Company

* 13 Polymethylsilsesquioxane: Tospearl 145A from GE Toshiba

* 14 Sodium Ascorbyl Phosphate: Stay-C 50 available from DSM

* 15 Panthenol: DL-Pantenol available from Roche

* 16 Tocopherol Acetate: available from Eisai Co.Ltd.

* 17 Audi extract: Audi extract BG sold by Maruzen Pharmaceuticals

Preparation Method of Example 1-6

The compositions described above can be prepared by any method known to those skilled in the art. The composition is suitably prepared as follows:

(1) All oily components and surfactants are mixed in a container and heated to 75 ° C. or higher to melt the solid oily component, if included.

(2) Water-soluble thickeners Other than water-soluble and heat-stable components are dissolved in water in another container and heated to 75 ° C or higher.

(3) Mix the products of steps (1) and (2) until homogeneous.

(4) Water soluble thickening polymer is added to the product of step (3) and mixed until homogeneous.

(5) The product of step (4) is cooled to 40 ° C. or less.

(6) Other water soluble ingredients such as hesperidin and niacinamide, extracts and the like are dissolved in water and added to the mixture of step (5) above.

(7) If included, other remaining ingredients, such as fragrances, are added to the product of step (5).

(8) Fold the water-insoluble substrate and place it in an aluminum pouch for each unit.

(9) The emulsion liquid composition thus obtained in step (7) is poured into an aluminum pouch containing a water-insoluble substrate or a preformed gel patch and hermetically sealed.

Definition of ingredients

* 1 Glucosyl Hesperidin: Alpha-Gysperspere PS-CC available from Toyo Sugar Refining.

* 2 Niacinamide: Niacinamide USP available from DSM

* 3 pyridoxine hydrochloride: available from DSM

* 4 Xanthan Rubber: Keltrol sold by Kelco

* 5 Polyacrylamide: Sepigel 305 available from Sepik Inc.

* 6 acrylate / C10-30 alkyl acrylate crosspolymer: b. F. Pemulen TR-2 available from Goodrich Company

* 7 dipropylene glycol

* 8 Sodium Ascorbyl Phosphate: Stay-C 50 available from DSM

* 9 Titanium dioxide: Kobo GLW75CAP-MP sold by Kobo Products Inc.

* 10 Polysorbate 20: Tween 20 available from ICI Surfactants

* 11 Saccharomyces ferment filtrate: SKII Pitera, commercially available from Kashiwayama

Preparation Method of Example 7-12

The above-mentioned composition may be prepared by any method known to those skilled in the art. The composition is suitably prepared as follows:

(1) Any oily component, such as a fragrance, if present, is dissolved in advance in the surfactant and a small amount of water.

(2) The water soluble thickener, if present, is predispersed into water and / or water soluble wetting agents.

(3) All remaining ingredients are dissolved in water and / or water soluble wetting agents and pH is adjusted with a pH adjuster if necessary. You can also add heat if needed. When present, relatively oily components such as preservatives may be pre-dissolved in water soluble wetting agents.

(4) Mix the products of steps (1) and (3) until homogeneous.

(5) If necessary, the products of steps (2) and (4) are mixed until homogeneous using a high speed mixer.

(6) Fold the water-insoluble substrate and place it in an aluminum pouch for each unit.

(7) The liquid composition thus obtained in step (5) is poured into an aluminum pouch containing a water-insoluble substrate pouch or a preformed gel patch and hermetically sealed.

Example 13-16

Examples 13-16 are embodiments of gel sheets using a gel sheet composition as specified in Table 3 and a coating composition having the same composition as any liquid composition as specified in Tables 1 and 2.

Definition of ingredients

* 1 Agarose: Litex agarose HSB-LV 2500 available from FMC Bioproducts

* 2 Agar: Available from Greentech.

* 3 1: 1 mixture of xanthan rubber and locust bean rubber: Kelgum available from Kelco

* 4 Xanthan: Keltrol T available from Kelco

* 5 Locust empty rubber: Phytaluronate available from Pentapharm

* 6 Niacinamide: Niacinamide USP available from DSM.

* 7 Glucosyl Hesperidin: Alpha-Gysperspere PS-CC available from Toyo Sugar Refining

* 8 D-pantenol: D-pantenol USP available from DSM

The preformed sheet is made in a continuous line process comprising the following steps:

(1) dissolving all components in water, mixing and heating to about 80 ° C. (at least 5 ° C. higher than the sol-gel transition point) to form a sol phase.

(2) precooling the sol phase composition to a temperature between 0 ° C. and 5 ° C. above the sol-gel transition point;

(3) forming a gel sheet by pouring into a mold or pressing through a roller sheet former equipped with a cooling system and cooling the sol phase to a gel phase at a temperature of 20 ° C. or less;

(4) cutting the gel sheet composition with a die cutter.

The coating composition and the preformed gel sheet are placed in the same container and hermetically sealed.

This embodiment, represented by the previous examples, is useful as a skin care product. When applied to facial skin, they offer many advantages. For example, they can improve the fields of skin tone, skin whitening, whitening of skin spots, reducing skin paleness, and reducing fine lines. Significant improvement in this effect is observed when this example is used daily for a period of at least 4 weeks.

All documents cited in the Detailed Description of the Invention are, in relevant part, incorporated herein by reference, and no citation of any document should be construed as an admission to the prior art for the invention. Insofar as any meaning or definition of a term described herein is in conflict with any meaning or definition of a term in the literature incorporated by reference, the meaning or definition given to the term described herein takes precedence.

While particular embodiments of the invention have been illustrated and described, it will be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. Accordingly, all such changes and modifications that fall within the scope of the invention are intended to be included in the appended claims.

Claims (14)

As a skin care device,    (1) a dermatologically acceptable preformed substrate; And    (2) comprising a flavonoid compound, The device comprises a liquid medium for delivering the flavonoid compound. The device of claim 1, wherein the liquid medium comprises water. The device of claim 1 wherein the flavonoid compound is selected from the group consisting of substituted flavanones, substituted flavones, substituted chalcones, substituted isoflavones and mixtures thereof. 4. The device of claim 3, wherein the flavonoid compound is selected from the group consisting of glucosyl hesperidin, glucosyl rutin, glucosyl mycitrinin, glucosyl isoquarcitrin, glucosyl quacitrin, methyl hesperidin, and mixtures thereof. The method according to any one of claims 1 to 4, The substrate is water insoluble, the remainder of the device is formed of a liquid composition, the liquid composition comprises a liquid medium, The liquid composition is based on the weight of the liquid composition (a) about 0.001% to about 10% of a flavonoid compound; (b) a water soluble thickener that provides the liquid composition with a viscosity of about 10 mPas to about 600,000 mPas; And (c) contains water, Wherein the liquid composition is from 100% to 2000% by weight of the water insoluble substrate. The liquid composition of claim 5, further comprising from about 0.01% to about 15% of a vitamin B3 compound by weight of the liquid composition. The liquid composition of claim 6, further comprising 0.001% to about 15% of a vitamin B6 compound by weight of the liquid composition. The method according to any one of claims 1 to 4, The substrate is a gel sheet comprising a gelling agent and a hydrophilic solvent, the hydrophilic solvent is a liquid medium, The gel sheet comprises from about 0.001% to about 10% of the flavonoid compounds based on the weight of the gel sheet. The device of claim 8, further comprising a coating composition containing from about 0.001% to about 10% of the flavonoid compound by weight of the coating composition. The device of claim 9, wherein the gel sheet and the coating composition each further comprise about 0.01% to about 15% of a vitamin B3 compound. The device of claim 10, wherein the gel sheet and the coating composition each further comprise from 0.001% to about 15% of a vitamin B6 compound. As a skin whitening method, A method comprising applying the device of claim 1, 5 or 8 to the skin. As a method of providing the skin with an anti-aging effect, A method comprising applying the device of claim 1, 5 or 8 to the skin. The method of claim 12 or 13, wherein the device is applied to the skin for at least 5 minutes.