KR20060122073A - Sputtering precious metals syringe niddle - Google Patents

Abstract

A sputtering precious metal syringe is provided to increase sterilization and treatment effects by coating the surface of a syringe needle with the precious metals such as gold, silver, platinum, and iridium particles by sputtering. A method for coating the surface of a syringe having a syringe needle(20) with at least one of gold, silver, platinum, and iridium in the thickness of 0.01-50 micrometers by sputtering comprises low and high-temperature deposition steps of injecting inert gas under a vacuum condition by using a sputtering method using one of ion-beam, electro-beam, RF(Radio-Frequency), and laser; a first step of firstly depositing a precious metal film by targeting the precious metals under a first deposition condition; and a second step of secondly deposing another precious metal film on the firstly deposited precious metal film under a deposition condition different from the first deposition condition.

Description

Sputtering precious metals syringe niddle}

1 is an overall perspective view of a sputtering precious metal syringe of the present invention.

2 is a perspective view of a sputtering precious metal injection needle of the present invention.

3 is a perspective view of a sputtering precious metal injector of the present invention.

Figure 4 is a perspective view of the sputtering precious metal syringe and piston structure of the present invention.

5 is a block diagram of a sputtering precious metal needle of the present invention.

* Description of the symbols for the main parts of the drawings *

10: syringe 20: syringe needle

30: piston 40: piston head

60: piston handle portion 80: body grip portion

100: nozzle 120: syringe body

140: catheter 180: chamber

200: cowwood 220: target

240: power source 260: anode

280: vacuum discharge port 300: gas inlet port

340: vacuum pump 360: silicon oxide film

380: through hole 400: syringe holder

420: inert gas 440: rotating body

The present invention is a syringe (10) used to inject a drug solution to a human or animal in a medical institution, to collect blood or secretions, or to practice experiments in a laboratory or a pharmaceutical company school

 (注射器, syringe) Regarding the injection needle 20 attached to the syringe,

  Originally designed by C.G. Pravaz of France in 1853, he injects iron chloride solution using his syringe (10) to treat patients with an aneurysm.

The syringe 10 is composed of a syringe and a needle 20, and its capacities vary. Recently, a disposable plastic syringe 10 is used for the prevention of serum infection. In order to minimize the pain during the injection needle 20 is also made of a large amount of needle 20 is made of a plastic or silicon material.

 As is known through mass media recently, more than 200,000 bacteria / cm 2 to 300,000 bacteria / cm 3 of bacteria are incubated in human hands, and the number of bacteria detected when washing and sterilization is neglected is approximately 5 million / 10,000 cm2 to 3200 / ㎠ E. coli was found to be 3500 / ㎠ to 1100 / cm2, and in severe cases ticks, fungi, and parasites were recently reported by airwaves. 10) Contamination or infection is a very serious phenomenon.

  The present invention relates to a syringe 10 used in a medical institution or a hospital laboratory laboratory as described above, the syringe 10 is injected or pulled blood and body fluid

Versatile for anesthesia, quantitative mixing of drugs, or experimenting with substances or drugs

It is used.

The present invention relates to a method for coating antiseptic noble metal (gold, silver, platinum, iridium) materials on the surfaces of the syringe 10 and the needle 20 inserted into a living body by sputtering. Preferably, the anti-sterile noble metal (gold, silver, platinum, iridium) film is coated on the surfaces of the syringe 10 and the needle 20 through a plurality of sputtering steps. By attaching to the surface of the syringe 10 and the needle 20 on the film, it is possible to form a thin film and a uniform film to a high melting point material at a relatively low temperature, and reactive sputtering can be performed by a reactive gas, thereby providing excellent adhesion. .

On the other hand, as mentioned above, as recently known through the media, humans usually have 200,000 bacteria / cm 2 to 300,000 bacteria / cm 3 or more of the bacteria in the hands, and when the hand washing and sterilization are neglected, The number is approximately 5 million / cm 2 to 3200 / cm 2 million E. coli was found to be more than 3500 / cm 2 to 1100 / cm 2, and in severe cases ticks, fungi, and mites were recently reported by airwaves. Contamination and infection of the syringe 10 and the needle 20 to be administered by hand may be a very serious phenomenon.

  Recently, many of the syringes 10 used in domestic medical institutions through airwaves exceeded the toxic content standard of the International Organization for Standardization (ISO), and in particular, to facilitate the insertion of the human body on the surface of the conventional stainless steel needle 20. It is amazing to us that it is known to have been coated with silicone material and used on patients.

The syringe 10 and the needle 20 coated with the anti-bacterial noble metals (gold, platinum, iridium, silver) of the present invention are coated at the time of manufacture of the main body of the injection machine 10 without physical and electrical sterilization. It contains an antiseptic substance, which can relieve pain in the patient's injection and increase the injection allergy and treatment effect.

Currently, stainless steel is used as the material of the needle 20, and the needle 20 made of stainless steel has no sterilizing effect.

The present invention relates to depositing gold, silver platinum, and iridium, which are antibacterial precious metals, on the surface of a conventional needle 20 by sputtering.

Recently, the sputtering method is used for the coating of high-tech materials, and the metal film deposition technique currently used includes sputtering, plating, chemical vapor deposition, and the like. The sputtering method which has several advantages, such as a (b) characteristic, an impurity mixing amount, low temperature deposition, and a high deposition rate, is more widely used.

In the present invention, particles on the surface of the needle 20 are oriented in the direction from the target 220 by sputtering.

In addition, because the mean free path of molecules of sputtering gas is longer than the center of the target 220 and the distance between the syringe 10 and the needle 20, the sputtered particles may reach the injector 10. Before being present, the chance of sputtering by molecules of the sputtering gas may be less.

 Thus, the sterile noble metal film may be uniformly deposited on the inner surface of the through hole 380 formed near the central portion and the circumferential portion, respectively. In addition, in the present invention, since the syringe 10 and the needle 20 are rotated about an axis perpendicular to the surface at the time of film deposition, the thickness distribution of the noble metal film on the surface of the syringe 10 is uniform and uniform. It has the advantage of being.

The present invention, as described above, the anti-sterile noble metal gold, silver, platinum, iridium target 220 and the anti-sterile target 220 is arranged to face away from the target 220 in the interior of the vacuum chamber (180) Providing and exposing to use gas in the sputtering apparatus; Supplying at least one reactive gas into the sputtering apparatus; Supplying power to the sputtering device to form; Depositing a gold, silver, platinum, and iridium film, which is an antimicrobial noble metal, on the surface of the injection machine 10 at a temperature of 20 to 400 ° C. by an action to a thickness of 0.01 to 50 μm; And after the deposition step, the temperature of the chamber is raised to 300 to 800 ° C., and gold, silver, platinum, and iridium films, which are antibacterial noble metals, are deposited on the surface of the primary syringe 10 to a thickness of 0.01 to 50 μm. Including the step, the functional syringe 10 and the injection needle 20 having an antiseptic power will be born.

The present invention is to solve the conventional problems as described above, the present invention targets the precious metals platinum, gold, silver, iridium by the technique of the sputtering coating method different from the general plating or coating method in the chamber It is intended to manufacture a functional syringe 10 having antimicrobial function, sterilization function and far-infrared radiation by coating the surface of the syringe body 10 and the piston 30 handle needle 20 by inputting it and particle size.

The present invention relates to a syringe 10 including a needle 20 used in a medical institution or a hospital laboratory laboratory as described above, the syringe 10 is injected or ringer, blood and body fluids, anesthesia or quantitative medicine The present invention relates to a syringe (10) used for mixing or experimenting with substances or medicines by sputtering gold, silver platinum, and iridium, which are antibacterial precious metals, on the surfaces of a conventional syringe (10) and a needle (20). It is about depositing.

In the sputtering of the present invention, when high-energy particles collide with the surface of a solid, atoms of the target material 220 are exerted out of the surface by exchanging momentum by a completely elastic collision.

Applying a negative voltage to the target in the vacuum and argon (Ar) gas and vacuuming to the appropriate vacuum pump 240 causes glow discharge and applies a magnetic field to the target 220 to evaporate. Will be promoted.

When ions collide with kinetic energy larger than the binding energy between atoms of a material

This ion bombardment pushes atoms between the lattice of the material to different locations,

The phenomenon of surface escape of atoms is called "sputtering" in physics.

In addition, sputtering in thin film deposition can be regarded as a concept including two processes of release of target atoms and attachment of the atoms to a substrate, and the process of sputtering process. The best feature is that almost all materials can be used as targets because the movement of the deposited material into the vapor phase is not a chemical or thermal process but a physical momentum exchange process. There is an advantage.

Using the sputtering phenomenon, the syringe 10 and the needle 20 are

A precious metal film is formed on the surface, and the precious metal scanner 10 of the present invention is formed by using an ion beam, an electron beam, or a radio-frequency laser sputtering. The coating has the advantage of higher quality, simplicity and reproducibility, and the biggest advantage is that it does not necessarily require a vacuum, unlike other methods, and that liquid or gaseous deposition materials can be used. There is this.

Excimer Laser sputtering produces 248 nm of KrF (Chryrofluoride), 193 nm of ArF (argon fluoride), 308 nm of XeCl, pulses of 1-20 Hz, and energy per unit area per pulse. The lens is focused to about / cm ^ 2.

The target 220 uses a polycrystalline ceramic and uses a substrate similar to the crystal structure of the thin film component to be made, and Al 2 O 3 (sapphire) having a triangular base plane hexagonal structure, and LaAlO 3 (3.838 A) according to the lattice constant of the rectangular base plane. ), SrTiO 3 (3.905 A), MgO (4.212 A), and the like, and glass, stainless steel, and the like.

Pulsed Laser Deposition (PLD) Sputtering is a vacuum chamber 180 for the ceramic target 220 of a material to be made in a manner of physical vapor deposition to form a thin film (thin film). The precious metal material of the present invention which is relatively small in size. It can be said that it is suitable for thin film 10).

One of the advantages of PLD (Pulsed Laser Deposition) is that

1. Atomic spray coating, easy to transfer complex composition of target 220 material

A method such as (MBE molecular beam epitaxy) requires several sources. For example, if a material such as gallium nitride (GaN) is deposited with a thin layer of multiple layers, Ga is required separately.

If there are more members, PLD uses YBCO without separating Y, Ba, Cu, O if it wants to make superconductor (YBCO) as target 220, and high temperature superconductivity is superconducting at relatively high critical temperature. Say this happens.

When superconductivity occurs at approximately 77K (liquid nitrogen temperature minus 196 degrees), it is commonly referred to as high temperature superconductivity. The high temperature superconductor is an oxide superconductor, YBCO, a material that contains yttrium, barium, kappa, and oxide. In other words, it is a ceramic-based material. It has a merit that it can be used in liquid nitrogen because its critical temperature is over 77K. This relatively easy to be implemented in the thin film.

Like this, laser sputtering is very fast and the deposition rate can be controlled relatively. Even when a thick film having a thickness of 1 micrometer is required, it is relatively faster than other sputtering methods. Therefore, it is rapidly developing into a new sputtering method.

The deposition principle is to collect a high output laser light into a deposition target located in a vacuum chamber, and the pulse rapidly raises the temperature of the precious metal syringe 10, which is the deposition material. Get up.

When the syringe holder 400 is placed near the deposition target 220, the molten material is blown onto the substrate to be uniformly deposited, and the high temperature deposition step of depositing the remaining film by raising the temperature above the deposition temperature of the low temperature deposition step and the low temperature deposition step. It is extremely preferable to use a two-stage deposition method and a laser deposition method comprising a.

Under a first deposition condition, a first step of depositing a noble metal film having a predetermined thickness on the surfaces of the syringe 10 and the needle 20 of the present invention; And a second step of second depositing the noble metal film on the primary deposited noble metal film again under the deposition conditions changed to be different from the first deposition condition. The anti-sterile noble metal (gold, silver, platinum, iridium) target ( 220 and the metallic injection device (10) which is a coating in the chamber 180; Providing a platinum, iridium target (220) and the antimicrobial target (220) arranged to face away from the target (220) to expose to use gas in the sputtering apparatus; Supplying at least one reactive gas into the sputtering apparatus; Supplying power to the sputtering device to form; Depositing a gold, silver, platinum, and iridium film of anti-sterile noble metal on the surface of the syringe 10 and the needle 20 at a temperature of 20 to 400 ° C. by an action to a thickness of 0.01 to 50 μm; And after the deposition step, the temperature of the chamber is raised to 300 to 800 ° C., and gold, silver, platinum, and iridium films, which are antibacterial noble metals, are deposited on the surface of the primary syringe 10 to a thickness of 0.01 to 50 μm. Introducing an inert gas 320 into the chamber 180 including the step; Rotator to rotate the syringe holder 400 with the syringe 10 for effective coating of the syringe 10 around the syringe holder 400 and an axis perpendicular to the surface of the syringe 10. A gas inlet port 300 for introducing a chamber 180 to which a 440 is attached and a sputtering gas into the chamber 180;

A target 220 for emitting particles by sputtering set in the chamber 180;

The surface of the syringe 10 including the needle 20 is preferably installed perpendicular to the direction in which most of the particles are released from the target 220 by sputtering.

SUMMARY OF THE INVENTION An object of the present invention is to provide a method for producing an antibacterial noble metal (gold, silver, platinum, iridium) film having a low half width and low roughness using sputtering deposition.

Next, a brief description of the sputtering syringe 10 of the present invention for achieving the above object is as follows.

1 is a perspective view showing the entire needle 10 made of the structure of the injection needle 20 and the main body and the piston 30 in a perspective view of the sputtering precious metal syringe of the present invention,

Figure 2 is a perspective view of the sputtering precious metal injection needle 20 of the present invention, the connection portion that detaches from the catheter 140 of the body 20 of the syringe and the pointed tip of the needle 20 to stab or suck It shows the gynecological needle 20 and the injection needle 20 in which the injection is ejected

3 is a perspective view of the sputtering precious metal injector 10 of the present invention, with a cylindrical storage body for receiving an injection liquid and a marked eyelid and an injection needle 20 capable of grasping the injection degree of the injection with the naked eye, and the injection needle 20 A syringe with a catheter 140 for ejecting the injection solution to the nozzle 100 of the 20 and a gripping portion 180 fitted to a finger to improve the gripping area when the drug is put into or administered to the syringe 10 of the hand. Body 220 is shown in a perspective view.

4 is a perspective view of the sputtering precious metal syringe and piston structure of the present invention;

The injection liquid is inserted into the piston 30 head 40 and the piston 30 head 40 inserted therein into the syringe body 220 which serves to eject the power by the force of a person or a machine to facilitate the compression operation. Piston 30 is shown in the perspective view of the piston 30 of the syringe 10 consisting of a handle.

5 is a block diagram of a stuffing syringe 10 of the present invention.

In sputtering of the present invention, the vacuum chamber 180 is used to generate ions. The ions generated in the chamber 180 allow the ions generated in the chamber 180 to evaporate a solid in a high vacuum state on the surface of the injection machine 10. to form a thin film or a thick film. First, argon (Ar) gas is used to form a coating particle.

The syringe 10 and the needle 20 are placed on opposite parallel plates connected to a high voltage power source. The deposition process first turns the chamber 180 into a vacuum by operating a high efficiency vacuum pump 340 and then sputtering at low pressure. Gas, usually argon, flows into the chamber 180.

 When voltage is applied to the electrode, argon gas (Ar +) is ionized and metal ions are generated between the plates. Since the plate covered with the source material is maintained at the negative potential, the argon ions are accelerated to the plate covered with the source material. The impact of the argon ions causes the source atoms and molecules to be released from the plate and fly to the surface of the syringe 10 to be deposited. will be.

 On the other hand, in the vacuum of 0.001 to 0.10 Torr in the inert (mainly argon) chamber 180, a high voltage of thousands of volts is applied between the electrodes to cause an abnormal discharge, thereby causing the inert ions to collide with the target 220 to convert the momentum into the target 220. The material is scattered with a gas and reaches the surface of the syringe 10 including the needle 20 attached to the syringe holder 400 is a technique of high concentration coagulation using gas ions.

The diameter of the target 220 is, for example, 200 mm, the distance between the target 220 and the injection holder 400 is, for example, 200 mm, and the area where most of the particles are emitted is an area where the diameter of the target 220 is 100 mm. It is located near the rear side of the target 220 so that it can be.

In the sputtering apparatus configured as described above, the distance between the target 220 and the injector 10 becomes longer than the diameter of a general sputtering technique, and sputtering is performed at a low pressure, so that the particles are not dispersed by the molecules of the sputtering gas and coated. The chain injector 10 can be reached.

On the other hand, in the circumferential portion of the injection machine 10, the number of particles discharged from the circumferential region of the target 220 by sputtering is smaller than the particles emitted from the central portion of the target 220.

Therefore, in the through hole 380 formed in the silicon oxide film 360, the Ti film formed on the inner wall surface is formed in the circumferential portion of the syringe 10 rather than the thickness at the portion closer to the center of the syringe 10. It has a thicker thickness at the closer part.

 The surface of the needle 20 and the syringe 10 are oriented in the direction in which most of the particles are released from the target 220 by sputtering, and a line perpendicular to the syringe 10 is the center of the target 220. The syringe 10 or the needle 20 holder 400 is positioned in such a way that it can almost penetrate through it. The sputtering gas is then introduced into the chamber 180 and consequently, the mean free path of molecules of sputtering gas is longer than the distance between the center of the target 220 and the syringe 10, the needle 20 And in a state in which they can be rotated around an axis perpendicular to the surface of the injector 10, the particles are released from the target 220 by sputtering.

The direction in which most of the particles are released from the target 220 by sputtering is very preferably a direction perpendicular to the surface of the target 220.

Example 1

Anti-sterile noble metals (gold, silver, platinum, iridium) are deposited on the injection machine 10 by sputtering under the following conditions.

Deposition process,

Basic pressure: 10 -8 Torr or less

Gas used: Ar (99.99%), oxygen (99.999%)

Ar Pressure 5 ~ 40 torr

Gas Flow 9 cc / min

Temperature Room Temperature

Power: 80-150 W

Target 220: Purity 99.99% AG

Coating sieve: needle in stainless steel (20)

Chamber 180 temperature: 400 ° C.

First, after setting the deposition power source 240 to 120 W, the antimicrobial noble metal film was manufactured by varying the deposition pressure. The antimicrobial noble metal film showed the change in the electrical resistivity and adhesion properties according to the deposition pressure. At the deposition pressure of 20 torr, the electrical resistivity was the smallest at 5.014 μΩ cm, and at higher deposition pressures, the electrical resistivity tended to increase, and silver coated on the surface of the needle 20 in nano units. It was very soft and formed uniform.

As described above, in the apparatus for implementing the sputtering method using the deposition step of the present invention, a cathode wood 200 is installed in the chamber 180, and a precious metal (gold, silver, platinum, iridium) is provided below the cathode wood 200. ) Is attached to the precious metal target 220 to be coated. The target 220 is provided with a power source 240 for applying a DC bias.

A positive pole opposite to the same axis and parallel to the target 220 is provided, and the injection needle 10 or the injection needle with the needle 20 attached to the upper portion of the anode 260. (20) The holder 400 is located. In addition, a vacuum system including a vacuum pump 340 is installed to introduce an inert gas such as oxygen and argon inside the chamber 180 and generate a vacuum inside the chamber 180. When sputtering deposition is performed using such a device, particles generated by colliding with + generated ionized noble metal gas colliding with the target 220 to which a negative bias voltage is applied are blown toward the injection device 10, thereby injecting the injection device 20. And the needle 20 is to be deposited on the surface of the syringe 10 attached to the holder 400.

Meanwhile, a vacuum discharge port 280 for discharging gas from the chamber 180 is formed at the bottom wall of the chamber 180, and the vacuum pump 340 is connected to the vacuum discharge port 280. In addition, a gas inlet port 300 for introducing an inert gas 320, such as an argon gas, into the chamber 180 is formed on the sidewall of the chamber 180.

That is, the pressure in the chamber 180 may be adjusted to maintain the predetermined pressure by introducing the inert gas 320 into the chamber 180 through the gas inlet port 300.

The target 220 is also located near the rear side, ie near the side, where the negative electrode is in contact. The area of the target 220 where most of the particles are released by sputtering is determined according to the position of the magnet placed.

In addition, the surface of the syringe 10, including the needle 20, is in such a way that the surface can be oriented perpendicular to the direction in which most of the particles are released from the gold, silver, platinum, and iridium targets 220 by sputtering. Is located.

In addition, the distance between the injection device 10 and the center of the target 220 is set so that the pressure in the chamber 180 can be shorter than the average free path of molecules of the inert gas 320 when the pressure in the chamber 180 is adjusted at a predetermined pressure. Rather, it is preferably set longer than the length of the syringe 10.

The following is a diagram showing the electrical conductivity and thermal conductivity of the metal as a reference for understanding the injector 10 coated with a noble metal of the present invention,

The thermal conductivity shown below has units of kcal / hr

The temperature conversion coefficient has 10 to 4 digits and the temperature K

Thermal conductivity = thermal conductivity x (1 + 10-4 x k x temperature conversion factor).

* Thermal Conductivity Table *

Metal --------- thermal conductivity ----- temperature conversion coefficient,

------ 360, -------- (-1.71),

Aluminum -------- 175 ------------ (+ 2.39),

Gold ----------- 265 ------------ (+0.40),

Copper --------- 300 to 340 ------ (-1.89),

Iron ---------- 40 to 45,

Iridium ------ 51 ------------- (-5.10),

Nickel --------- 50 -------------- (-3.1),

Platinum --------- 60 ------------- (-0.53),

Rhodium -------- 77 -------------- (-10.0)

Comment -------- 55 -------------- (-8.0)

Zinc -------- 95 ------------- (-1.5)

Brass --------- 75-100,

Bronze --------- 51 to 61,

The chart shows the thermal and electrical conductivity of conventional metals.

 Example 2

 The cause of ejection is to closely examine the injector 10 coated with the noble metal.

Applicant has applied a syringe of 2 ml, 5 ml, 10 ml injection needle 20 and Ringer's injection needle 20, dental anesthesia with a plastic body and a piston made of rubber or silicone and a stainless steel needle in the form of a conventional syringe on the market. 100 new needles 20 each were purchased from a medical device store, and only the needle part was commissioned to the S University Research Institute. The noble metal was coated to a thickness of 1 μm by the sputtering method and the clinical trials were performed including the applicant as follows. The present invention has been completed to confirm that the result is expected to be sufficiently applicable and medically, and the present invention has been completed to confirm that the present applicant is sufficiently applicable to medically and industrially. .

Example 3

In order to actively test this, the main cause of injection is the needle 20 coated with the precious metal of the present invention by the sputtering method, the syringe 10 incorporating the precious metal with a plastic material, and the general stainless steel needle 20 and the general syringe ( 10) The same drug was injected and 10 patients who were hospitalized for inflammatory diseases in general hospitals were classified into 10 groups by gender and age.

Clinical subject Stainless steel needle Precious metal needles Precious metal injection feeling stainless Needle feeling A: 19 years old boy disease Antibiotic injection morning dose, Antibiotic injection evening dosing, no response pain B: 18 years old schoolgirl disease: peritonitis Antibiotic injections, Ringer's injections, evening doses, Antibiotic injections, Ringer's injections, morning doses, A slight reaction ache C: 28 years old Male disease name: Traffic accident Antibiotic injections, ringer injections, analgesic injections, evening doses, Antibiotic injections, Ringer's injections, analgesic injections, morning doses, no response pain D: 29-year-old woman Disease name: Appendicitis Antibiotic injections, Ringer's injections, morning doses, Antibiotic injections, Ringer's injections, evening doses, no response ache E: 36-year-old male illness: Traffic accident Antibiotic injection, analgesic injection evening dose, Antibiotic injections, analgesic injections, morning doses, no response pain F: 39-year-old woman Antibiotic injections, Ringer's injections, analgesic injections, Antibiotic injections, Ringer's injections, analgesic injections, morning doses, Slightly ache G: 42-year-old male disease name: Gastric surgery Antibiotic injections, Ringer's injections, evening doses, Antibiotic injections, Ringer's injections, morning doses, no response pain H: 48 year old Female disease: Arthritis Antibiotic injection morning dose, Antibiotic injection evening dosing, no response ache I: 56-year-old male Disease name: Bronchitis Antibiotic injection morning dose, Antibiotic injection evening dosing, no response pain J: 55 years old Female disease: Arthritis Antibiotic injections, analgesic injections, morning doses, Antibiotic injections, analgesic injections, evening doses, no response ache

Example 4

This experiment was performed when the precious metal needle 20 and the stainless steel needle 20 were inserted into or removed from the long-term hospitalized patients. Is shown in the following data.

Clinical subject stainless Material of needle, Precious metal needles, Post Effects of Precious Metal Injection Needles stainless Needle After Effects A: 19-year-old male disease name: cellulitis Antibiotic injection morning dose, Antibiotic injection evening dosing, no response no response B: 18 years old female disease: peritonitis Antibiotic injection, Ringer's injection, evening dose, Antibiotic injection, Ringer's morning dose, There is some bookkeeping Allergies, itching, swelling C: 28-year-old male Disease name: Traffic accident Antibiotic injections, ringer injections, analgesic injections, evening doses, Antibiotic injections, Ringer's injections, analgesic injections, morning doses,  no response Swelling, Itching, Part 29 Female disease name: Appendicitis Antibiotic injections, Ringer's injections, morning injections, Antibiotic injections, Ringer's injections, evening doses,  no response Swelling, itching E: 36-year-old male Disease name: Traffic accident Antibiotic injection, analgesic injection evening dose, Antibiotic injections, analgesic injections, morning doses,  no response Swelling, itching F: 39-year-old woman Antibiotics, injections, ringer injections, analgesics, injections, evening doses, Antibiotic injections, ringer injections, analgesic injections, morning doses,  no response Allergies, itching, swelling G: 42-year-old male Disease: Gastric surgery Antibiotic injections, Ringer's injections, evening doses, Antibiotic injections, Ringer's injections, morning doses,  no response Swelling, itching ㅓ 48 year old Female disease: arthritis Antibiotic injections, morning dose, Antibiotic injection evening dosing,  no response bookkeeping I: 56-year-old male Disease name: Bronchitis Antibiotic injections, morning dose, Antibiotic injection evening dosing,  no response Swelling, pain J: 55 years old Female disease: Arthritis Antibiotic injections, analgesic injections, morning doses, Antibiotic injections, analgesic injections, evening doses,  no response itch

[Example 4] The precious metal injection needle 20 and stainless steel for the patient

Most patients answered that the stainless steel needle 20 was rough and very painful when inserted, and the precious metal needle 20 was lubricated when it was hit or removed. It was found by the above experiment that the wound was soft and not painful and the wound healed much faster than the conventional needle 20, and there was no swelling, allergy, itching and inflammatory reaction. .

* All the above data is the actual experimental data of K hospital in Seoul *

This completes the precious metal needle 20 by the sputtering method of the present invention.

As described above, the examples and data of the noble metal needle 20 used in various sputtering methods were examined. Methicillin-resistant Staphylococcus aureus) can be sterilized, and the antibacterial activity was found to be very excellent.

As described above, the conventional needle 20 has no antibacterial activity on its own and the needle 20 is always exposed to the surrounding contaminants and bacteria and viruses of the hands of the injection particles, so that various pathogens may occur. In particular, the virus can be easily transmitted to others through the needle 20 is also a social problem.

Therefore, the hygiene management of the syringe 10 including the needle 20 to penetrate the body of the human body is required more thoroughly, so that people can use a safe, clean and hygienic needle 20 can greatly contribute to national health It is an excellent invention that can be said.

The present invention can be coated by the sputtering method on the surface of the injection machine 10 with a noble metal target 220 to sterilize various fungi, bacteria, viruses, generating a large amount of negative ions and far-infrared rays while having the effect of pain relief during insertion It is sterilized by germs and viruses that can be infected by the hand of the person who gives the injection and uses a clean, safe and clean syringe (10) to have an effect on people's health and health. In the above description of the preferred embodiments and preferred embodiments of the present invention, those skilled in the art to which the present invention pertains to the present invention without departing from the spirit and scope of the invention described in the claims It will be understood that variations, modifications and substitutions are possible.

The present invention relates to a syringe and needle 20 used in medical institutions, laboratories, pharmaceutical companies as described above, in particular gold, anti-sterile precious metal by the sputtering (sputtering) coating method on the surface of the needle 20 made of precious metal, Silver, platinum, and iridium by coating the particles of the noble metal injection needle 20 by the sputtering coating method that can increase the antibacterial treatment effect by the injection needle 20.

The anti-sterile noble metal film production method according to the sputtering method according to the present invention configured as described above, by appropriately adjusting only the deposition conditions during sputtering, it satisfies both the low resistivity and high adhesion properties at the same time without complicated additional processes such as heat treatment A sterile noble metal membrane can be prepared, and the syringe 10 and the needle 20, which are easy to produce and reproduce bacteria, pathogens and microorganisms, are clean and hygienic, and the lubricating action of the noble metals (gold, silver, platinum, iridium) The invention of the injector 10 including the needle 20 of the excellent precious metal material to obtain an effect that can block the pain during the procedure of the injection needle 20.

test subject unit Strain Precious metal coating (after 30 minutes) Staphylococcus aureus CFU / mL 3.4 X 10 ³ 0 Pneumococcal CFU / mL 3.1 X 10 ³ 0 MRSA CFU / mL 3.3 X 10 ² 0

 (This test report is the analysis data of Korea Testing Institute)

Claims (8)

 In the syringe 10 and the needle 20 for coating a precious metal of gold, silver, platinum or iridium by the sputtering method, Inert gas 320 is injected under vacuum using an ion beam, an electron beam, or a sputtering method selected from RF (Radio-Frequency) and laser (Laser). And a first step of first depositing the noble metal film by targeting the noble metal (220) under a first deposition condition, including a low temperature deposition step and a high temperature deposition step; Under a deposition condition different from the first deposition condition, the method further includes a second step of depositing a noble metal film on the noble metal film, wherein the surface of the syringe 10 including the injection needle 20 has a coating thickness of 0.01 to 50 μm. Sputtering precious metal injectors characterized by being precious metal coated. The method of claim 1, The chamber 180 includes a syringe 400 to which the antimicrobial noble metal (gold, silver, platinum, iridium) target 220 and the needle 20 attached as a coating are attached, or a holder 400 to which the needle 20 is fixed. Positioning therein; Providing the antimicrobial target (220) spaced apart from the target (220) and exposed to the gas in the sputtering apparatus; Supplying at least one reactive gas into the sputtering apparatus; Sputtering precious metal injector, characterized in that the precious metal injector (10) is coated in a sputtering manner by supplying a power source (240) to the sputtering device. The method according to claim 1 or 2, Depositing a coating film to a thickness of 0.01 to 50 μm on any one of gold, silver, platinum, and iridium, which are antibacterial precious metals, on the surface of the syringe 10 including the needle 20; After the deposition step to increase the temperature of the chamber 180 to 300 ~ 800 ℃ and further comprises the step of depositing the surface of the precious metal syringe 10 with a coating thickness of 0.01 to 50㎛ Sputtering Precious Metal Injector. The method of claim 3, wherein Injecting the inert gas 320 into the chamber 180 under vacuum using the vacuum pump 240 and the injector holder 400 having the injector 10 or the needle 20 attached thereto. A chamber 180 to which the rotating body 440 is rotated; A gas inlet port (300) for introducing a sputtering gas into the chamber (180); Sputtering precious metal injector, characterized in that consisting of a target 220 for emitting the precious metal particles by the sputtering set in the chamber (180). The method according to any one of claims 1 to 3, The precious metal target 220 particles are installed in a linear direction in which the particles are released from the target 220 by sputtering, and the ions generated in the chamber 180 cause high vacuum on the surface of the syringe 10 including the needle 20. A sputtering noble metal injector, comprising evaporating a solid to form a thin film or a thick film. The method of claim 1, In the chamber 180, a cathode wood 200 is installed, and a precious metal target 220 to be coated with any one of precious metals (gold, silver, platinum, iridium) is attached to the lower portion of the cathode wood.  The target 220 is provided with a power source 240 for applying a DC bias Positive poles opposite to and parallel to the same axis as the target 220 are provided, and the positive electrode 260 is formed by attaching a syringe 10 or a needle 20 to the upper portion of the anode 260. After the ionized precious metal gas collides with the target 220 to which the bias voltage of the cathode is applied, the separated precious metal particles are fixed to the holder 400 or the needle 20, and deposited on the surface of the syringe. Characterized sputtering precious metal syringes. The method of claim 1, Excimer Laser Sputtering is KrF 248 nm, ArF (argon fluoride) is 193 nm, XeCl emits ultraviolet light at 308 nm, pulses are incident at 1 to 20 Hz, and energy per unit area per pulse is several J / cm ^ 2. The target 220 is Al 2 O 3 (sapphire) having a triangular base plane hexagonal structure, and LaAlO 3 (3.838 A), SrTiO 3 (3.905 A), MgO (4.212 A), glass, and stainless steel according to a rectangular base plane lattice constant. Injector 10 further comprising a material of steel and attached to injector holder 400 in which the target 220 is positioned in chamber 180 and a noble metal gas projecting a pulsed laser is facing the target 220. Sputtering precious metal injector, characterized in that deposited on the surface of the coating thickness of 0.01 to 50㎛. The method according to any one of claims 1 to 6, A sputtering precious metal injector, characterized in that the syringe (10) and the needle (20) coated by the sputtering method further comprises a fluid set and a ringer injection, anesthesia injection, and blood vessel injection.

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