KR20060112378A - Manufacturing method of isotonic soduim chloride solution - Google Patents

Abstract

A manufacturing method of isotonic sodium chloride solution and cleansing apparatus for contact lens is provided to effectively disinfect and sterilize viruses and bacteria and to remove foreign substances within the short time and protein on contact lenses in the lens receiver by oxidants generated by electrolysis in the electrode unit. The manufacturing method comprises the steps of preparing normal saline water by putting NaCl into the water, filtering the normal saline water, sterilizing the normal saline water by electrolysis of the normal saline water, and additional filtering the normal saline water. Also, the cleansing apparatus for contact lens comprises a lens receiver for accommodating lenses, at least one electrode unit including a negative electrode and a positive electrode which is set a part from the negative electrode with each other, a power supply for supplying electric current to the negative electrode and the positive electrode.

Description

MANUFACTURING METHOD OF ISOTONIC SODUIM CHLORIDE SOLUTION}

1 is a flow chart showing a conventional physiological saline production process

Figure 2 is a flow chart illustrating a manufacturing process of physiological saline according to an embodiment according to the present invention

3 is a schematic view of the manufacturing apparatus according to FIG.

4 is a schematic view showing the circuit portion of FIG.

5 is a cross-sectional view taken along the cutting line V-V of FIG.

Figure 6 is an experimental data graph showing the increase in the amount of chloride ions according to the electrolysis of brine

** Description of symbols for the main parts of the drawing **

S10: brine preparation step S20: sterilization step

S30: filtration step 100: sterilization apparatus using underwater discharge

110: tank 120: power supply

121: anode power line 122: cathode power line

130: electrode portion 131: positive electrode plate

131a: anode projection 132: negative electrode plate

132a: cathode projection 133: support

The present invention relates to a method for producing physiological saline, and more particularly, to a method for preparing physiological saline that can be quickly and easily prepared at the user or consumer level.

Generally, physiological saline is colorless transparent brine having a concentration of 0.85 w / v% to 0.095w / v% of sodium chloride equal to osmotic pressure with a human body fluid, and has a pH in the range of 4.5 to 8.0. In particular, physiological saline, which has been filtered and sterilized with impurities, is used by rhinitis patients to wash their noses and to clean and sterilize contact lenses.

Such physiological saline is prepared in the order shown in FIG. That is, a sterilization step (S1) of sterilizing a large amount of distilled water by heating at a high pressure of about 121 ° C. for about 30 minutes and administering sodium chloride (NaCl) as an osmotic pressure regulator to the sterilized distilled water to have the same osmotic pressure as a human body fluid. Preparing a saline (S2), administering a pH buffer to adjust the pH pH of about 6.5 to 8.0 (S3), and administering a preservative to prevent the growth of bacteria in the saline over a certain range (S4) ), And a filtration step (S5) for filtration with a filter to remove impurities, and a step (S6) for storing the filtered saline in the packaging container.

The sterilization step (S1) is to be heated to high temperature and high pressure, so that distilled water is placed in a large capacity container, it is made by heating and applying a high pressure.

In the saline preparation step (S2), instead of using medicinal sodium chloride (NaCl) as an osmotic pressure control agent, medicinal potassium chloride (KCl) may be used, and the same concentration as body fluid is set to about 0.9%.

The pH buffer administration step (S3) is to adjust the pH buffer, such as boric acid, citric acid, phosphoric acid in saline to adjust the pH range similar to body fluids.

In the preservative administration step (S4), physiological saline is prepared by using distilled water sterilized at high temperature and high pressure, so that the physiological saline is maintained at the time of manufacture, but in order to prevent the bacteria from propagating in the saline solution during long-term storage. Preservatives such as chimerosal, polyquid and dimed.

Since the sterilization step for removing the bacteria in the conventional physiological saline is carried out in a state of high temperature, high pressure should be provided with a pressure vessel capable of withstanding high pressure, having a pressure vessel capable of withstanding high pressure is practically physiological saline It is only possible for a manufacturer who specializes in manufacturing and it is impossible for a general user or a consumer to have a high pressure vessel. Therefore, the conventional method for sterilizing physiological saline according to a high temperature and a high pressure method is for a general user or a consumer to use a saline solution. It was not possible to make them directly and use them immediately.

That is, in the past, only a professional manufacturer can manufacture physiological saline, so that the physiological saline is manufactured in a large pressure container on a large scale. The physiological saline thus prepared is filled in a predetermined packaging container (S6) and commercially available. Due to the convenience of the user's purchase and the constraints of the cost of the packaging container is being sold in a large packaging container of about 1L or more. By the way, the physiological saline is sold in the packaging container (S6) is contaminated by exposure to the atmosphere after 3 to 4 days after opening the packaging container, there was a limitation in use should be used before being contaminated. Nevertheless, users who purchase and use commercial physiological saline should be discarded after 3 to 4 days after opening, but it is often used continuously without disposal, so that the use of contaminated physiological saline is neglected. Resulted.

In addition, preservatives are administered to store the saline solution for a long time until the packaging container is opened (S4), and the preservatives administered to the saline solution also have problems that cause side effects such as allergy to some users.

Therefore, there is an increasing demand for the user to use the physiological saline solution immediately after manufacturing for the hygiene and safety of the user.

The present invention relates to a method for producing physiological saline, which is not limited to a manufacturer, and allows a user to use physiological saline by simply preparing physiological saline at a user or consumer level.

Another object of the present invention is to allow the user to manufacture and use physiological saline immediately, it is possible to suppress the use of the preservatives required as long-term storage of physiological saline, and is generated by the user using contaminated physiological saline The problem is to get rid of it.

In addition, an object of the present invention is to provide a method for producing physiological saline which greatly reduces the production time required for the production of physiological saline by rapidly preparing physiological saline at the user or consumer level.

The present invention provides a brine manufacturing step of making saline by putting sodium chloride in water in order to achieve the object as described above; Sterilizing the electrolytically sterilizing the brine; It provides a method for producing physiological saline characterized in that it comprises a filtration step to remove the impurities of the sterile saline.

This simplifies the high temperature, high pressure sterilization process, which previously required large-scale equipment by sterilizing the brine by oxidants (ozone, hydrogen peroxide, HOCl, OH radicals, etc.) by electrolyzing the brine. In the case of electrolyzing brine having a concentration, since the more active electrolysis is made to produce oxidants (oxidants) more quickly, it is for greatly shortening the time required for the production of physiological saline.

In the sterilization step, the negative electrode part and the positive electrode part are spaced apart in the brine, and ozone (O ₃ ), hydrogen peroxide (H ₂ O ₂ ), and OH generated by electrolyzing the brine by applying a current to the negative electrode part and the positive electrode part. It is made of an oxidant such as a radical or HOCl, and the production and sterilization of the oxidant by the electrolysis is performed by the following steps (1) to (5).

(1) Ozone is generated by electrolysis of water (H ₂ O) and finally ozone is formed through the following process where O and O ₂ are combined.

^{_{H 2 O -> H + +}} (OH) ads + e -

_{(OH) ads -> (O} ) ads + H + + e -

_{2 (OH) ads -> O} 2 + 2H + + 2e -

2 (O) _ads- > O ₂

(O) _ads + O _2- > O ₃

(2) Hydrogen peroxide is produced by the direct route by the electrolysis of oxygen and the indirect route produced by the combination of OH radicals, an intermediate product produced by ozone decomposition. In other words,

^{_{O 2 + e - -> O}} 2 · -

_{^{O 2 + 2H + + 2e -}} -> H 2 O 2

With a direct path such as

OH + OH-> H ₂ O ₂

Is generated by an indirect path such as

(3) HOCl reacts with H ₂ O to form HOCl after Cl ⁻ ions in water bind with Cl ₂ . In other words,

_{^{2Cl - -> Cl 2 + 2e}} -

^{_{2H 2 O + 2e - ->}} H 2 + 2OH -

_{Cl 2 + H 2 O ->} HOCl + H + + Cl -

(4) OH radicals are instantaneously produced and disappeared, so they cannot be directly measured, but when ozone is present in water, they react with OH ^- or a counterbase of hydrogen peroxide to form a radical chain cycle. Produces OH radicals.

O ₃ + OH-> Radial Chain Reaction-> OH

O ₃ + HO ^2- (covalent base of H ₂ O ₂ )-> radical chain reaction-> OH

(5) Microorganisms (microorganisms) present in water are inactivated or removed by the oxidants produced, and the following microorganisms are removed by electrosorption, and the following microorganics are e- and It is removed by direct electrolysis reaction.

In other words, for Microorgainsm

M (Microorganism)-> Electrosorption-> Inactivation

Also,

M (Microorganism) + O _3- > Inactivation

M + OH ·-> Inactivation

M + HOCl-> Inactivation.

And about Microorganics,

M (Microorganics) + e--> M-

Also,

M (Microorganics) + O _3- > Product

M + OH

M + HOCl-> Product

That is, during electrolysis, oxidation and sterilization is performed smoothly by the mixed oxidants (O 3, H 2 O 2, HOCl, OH radicals) generated in the process of (1) to (5), and electrolysis is performed. Afterwards, high sterilization power is maintained by high residual HOCl.

At this time, the negative electrode portion and the positive electrode portion are formed with projections having sharp ends, such as conical shapes to face each other, more charge is agglomerated on the projections further promote the electrolysis reaction.

On the other hand, it may be configured to further include a filtration step to remove the impurities of the saline before the sterilization step. Through this, it is possible to effectively prevent the electrode part from being contaminated by the adhesion of impurities to the electrode part during the sterilization process by electrolysis.

And, the water does not necessarily need to be distilled water, tap water or ground water may be applied. Therefore, a general user can easily prepare physiological saline through a short time reaction by receiving tap water or ground water.

In the saline preparation step, when only a small amount of physiological saline of 1 L or less is required, water is placed in a container, and the saturated saline is made to have a salinity of about 0.9% in proportion to the amount of water contained in the container. By pouring into the container and mixing with the water. This can be done by adding medicinal sodium chloride directly, but it is easier to add a separate saturated sodium chloride solution than to accurately measure and mix the amount of sodium chloride powder. In addition, the saturated solution of sodium chloride (NaCl) has almost no change in solubility compared to the ambient temperature as shown in the table below. In other words, the amount of salt dissolution according to the change of temperature is slightly increased but the ratio is extremely minute, so that the amount of saline that can be utilized as physiological saline can be produced by adding a constant saturated sodium chloride solution according to the amount of water in the container. It becomes possible.

Temperature (℃) -15 -10 0 20 40 60 80 100 140 180 Solubility 32.73 33.49 34.22 35.8 36 36.6 37.3 38.4 42.1 44.9

On the other hand, if you want to prepare a large-capacity physiological saline solution of 1L or more, as described above, without mixing the saturated sodium chloride solution, it may be prepared by mixing about 1g tablet lumps of medicinal salt. That is, to prepare a medicinal salt tablet in 0.5g unit, if you want to prepare a saline solution of about 1 ~ 1.2ℓ Put two 0.5g medicinal salt tablet, to prepare a saline solution of about 2.0 ~ 2.3ℓ In this case, it is possible to prepare a proper saline solution by adding four 0.5 g medicinal salt tablets.

The sterilization step is performed by oxidizing the negative electrode part and the positive electrode part spaced apart from each other in the brine, and applying an electric current to the negative electrode part and the positive electrode part to electrolyze the brine, and the negative electrode part and the positive electrode part. The negative electrode protrusions and the positive electrode protrusions having sharp tips are formed on the parts so as to face each other. This is because even though a constant charge flows, a lot of charges are concentrated at the tips of the sharp protrusions of the negative electrode part and the positive electrode part, thereby further facilitating electrolysis. Therefore, when it is desired to induce the same electrolysis, it is possible to include a power supply having a lower capacity, and in particular, a battery having a small capacity can be utilized. In this case, the cathode protrusion and the anode protrusion may be formed of or plated with platinum (Pt) or titanium (Ti), which can most actively react with electrolysis. In addition, the thickness of the plating layer of the cathode projection and the anode projection is more thick than the plating layer thickness of the other portion is effective in terms of increasing the reaction life.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

However, in describing the present invention, a detailed description of known functions or configurations will be omitted to clarify the gist of the present invention.

2 to 5 show a physiological saline manufacturing process and a manufacturing apparatus used therein according to an embodiment of the present invention, Figure 2 is a flow chart showing the manufacturing process, Figure 3 is a manufacturing apparatus according to Figure 2 4 is a schematic view showing the circuit portion of FIG. 3, and FIG. 5 is a cross-sectional view taken along the cutting line VV of FIG.

As shown in the figure, the manufacturing process of physiological saline according to an embodiment of the present invention, the step of preparing a saline by mixing a predetermined sodium chloride in tap water (S10) and the filtration of the brine prepared by the filter first Primary filtration step (S20) to remove impurities, and sterilization step (S30) of electrolyzing the first filtered brine by sterilization and sterilization, and sterilized brine by secondary filtration to remove impurities It comprises a step (S40).

In the brine manufacturing step (S10), 1.8 g of sodium chloride should be put in a state in which 200 ml of tap water is put into a container to prepare 0.9% of saline. In this case, since the user often does not have a scale for measuring the amount of sodium chloride to be mixed, the solubility of the sodium chloride solution is 35.8 based on a room temperature of 20 ° C, and 5.0 ml containing 1.8 g of sodium chloride is used. By adding saturated sodium chloride solution, it is possible to obtain a sodium chloride solution having an appropriate concentration. The amount of such saturated sodium chloride solution can be easily prepared by measuring and mixing the scale by reading the scale attached to the measuring vessel having a small inner diameter to prepare the brine.

The primary filtration step (S20) is to prevent impurities from adhering to the electrode part in the electrolysis process by first removing impurities before the sterilization step (S30) by electrolysis.

The sterilization step (S30) is made by the sterilization apparatus 100 shown in Figs. The sterilization apparatus 100 is a container 100 for receiving the tap water 111, the power supply unit 120 for supplying power and the power supply from the power supply unit 120 through the power supply line (121, 122) tap water It is configured to include an electrode unit 130 for electrolytic decomposition.

Here, the electrode unit 130 includes a negative electrode plate 131 connected to receive the negative power from the power supply unit 120, a positive electrode plate 132 connected to receive the positive power from the power supply unit 120, and these electrode plates ( It is composed of the support 133 is installed 131,132. On the surfaces of each of the negative electrode plate 131 and the positive electrode plate 132 facing each other, as shown in FIG. 5, a plurality of pointed cone-shaped cathode protrusions 131a and anode protrusions plated with sufficient thickness are plated with platinum. 132a is formed such that the predetermined distance d1 is spaced apart from each other.

When the sterilization apparatus 100 configured as described above reaches a sterilization step (S20) of manufacturing physiological saline, power is supplied from the power supply unit 120 to the electrode plates 131 and 132, and as the power is supplied, each electrode plate ( Charge is concentrated in the cathode protrusion 131a and the anode protrusion 131b formed on the 131 and 132. Therefore, the electrolysis of tap water occurs violently between the projections 131a and 131b, and an oxidant (ozone, hydrogen peroxide, HOCl, OH radical, etc.) generated by electrolysis for only 2-3 minutes is in the tap water. By removing microorganisms, it is possible to prepare sterilized saline with increased sterilization.

More specifically, O- sterilizes powerful oxidation and bacteria and viruses, removes spores, OH- sterilizes as alkali and removes heavy metals, O2 increases dissolved oxygen in water, and makes O3 It is present only during electrolysis, but with strong germicidal power it can remove viruses, bacteria and spores. Therefore, it is possible to satisfy the microbial tolerance required for physiological saline that the amount of bacteria is 100 / g or 100 / ml or less and E. coli, Pseudomonas aeruginosa, Staphylococcus aureus and Salmonella should not be detected.

The second filtration step (S40) by filtering the sterilized brine again to remove the impurities once more it is possible to produce saline that meets the criteria of drinking water.

The physiological saline prepared by the above process, even if manufactured with tap water, satisfies the standard condition of pH 4.5-8.0 of physiological saline, and induces the electrolysis of tap water by flowing a charge to the electrode plate formed with the cathode and anode projections, respectively. Because it is sterilized, it is possible to produce saline solution easily even at the user scale even in places such as homes or hospitals even without large facilities.

On the other hand, compared to normal distilled water, the brine containing sodium chloride is more intense electrolysis, thereby increasing the amount of oxidant. FIG. 6 is a graph illustrating experimental data showing an increase in the amount of chlorine ions due to electrolysis by flowing a current of 5 V and 2.2 A in a brine having a concentration of 0.98% and pH6.39. As shown in the experimental results of Figure 6, the more intense electrolysis is made for the brine, sterilization step (S30) is made quickly. Furthermore, since the protrusions 131a and 132a are formed on the electrode plates 131 and 132 according to the exemplary embodiment of the present invention, the time required for sterilization is much shorter due to more intense electrolysis than the experimental results of FIG. 6. do.

On the other hand, one embodiment of the present invention is configured to include a brine manufacturing step (S10), the first filtration step (S20), sterilization step (S30), the second filtration step (S40) sequentially, the sterilization step (S30) ) May be additionally included, and any one of the filtration steps may be omitted, and may be adjusted according to the needs of those skilled in the art.

Although the preferred embodiments of the present invention have been described above by way of example, the scope of the present invention is not limited to these specific embodiments, and may be appropriately changed within the scope described in the claims.

As described above, the present invention is a brine manufacturing step of making a brine by putting sodium chloride in water, a primary filtration step of removing the impurities of the brine primarily, a sterilization step of electrolytic sterilization of the brine, and sterilization A sterilization apparatus having a pressure vessel capable of withstanding the high temperature and high pressure required for sterilization and including an electrode portion necessary for sterilization, instead of administering a pH buffer or preservative, including a secondary filtration step of removing impurities of the brine. Since only a filter necessary for filtration of impurities and impurities may be provided, a saline solution is prepared directly and easily at the level of a general user or consumer, and a method of producing a physiological saline solution enables the use of physiological saline immediately after preparation.

Through this, since the conventional saline should be stored for a long time, it is not necessary to use the required preservatives, people who have a sensitive reaction to the preservatives can use the saline prepared by the present invention without a sense of rejection.

In addition, since the electrolysis of the brine in the electrode unit having the cathode and anode protrusions can induce rapid generation of oxidants, if only drinking water meets the criteria, physiological saline can be prepared in about 2 to 3 minutes. It provides a method of producing a physiological saline.

In addition, by providing the projection part for electrolysis of water, a smaller capacity power supply part may be provided, so that a small capacity battery can be applied.

Furthermore, the sterile physiological saline as described above may be utilized for medical treatment of disinfecting the burn site or the infected site since HOCl remaining after electrolysis has a sterilizing power.

Claims (15)

Preparing a brine by putting sodium chloride in water; Sterilizing the electrolytically sterilizing the brine; A filtration step of removing the sterilized impurities of the brine; Method of producing a physiological saline characterized in that it comprises a. The method of claim 1, Method of producing a physiological saline characterized in that it further comprises a filtration step of removing impurities of the brine before the sterilization step. The method of claim 2, Method of producing a physiological saline characterized in that after the filtration step of removing the impurities of the sterilized saline again through the sterilization step. The method of claim 1, After the filtration step, the method of producing a physiological saline, characterized in that further comprising the sterilization step and the filtration one or more times. Preparing a brine by putting sodium chloride in water; A filtration step of removing impurities of the brine; Sterilization step of sterilizing by electrolysis of the brine; Method of producing a physiological saline characterized in that it comprises a. The method of claim 5, Method of producing a physiological saline characterized in that it further comprises a filtration step of removing the impurities of the sterilized saline after the sterilization step. The method according to claim 1 to 6, The water is a method of producing physiological saline, characterized in that any one of tap water, purified water, ground water. The method according to claim 1 to 6, The brine manufacturing step, Placing water in the container; Depending on the amount of water contained in the vessel, pouring saturated brine into the vessel so that the salinity is between 0.8% and 1.4% and mixing with the water; Method of producing a physiological saline characterized in that it comprises a. The method according to claim 1 to 6, The brine manufacturing step, Placing water in the container; Adding a mass of medicinal salt in the form of a tablet formed by unit weight according to the amount of water so that the water contained in the container has a salinity of 0.8% to 1.4%, and mixing the water with the water; Method of producing a physiological saline characterized in that it comprises a. The method according to any one of claims 1 to 6, The sterilization step is a physiological saline production method characterized in that the negative electrode portion and the positive electrode portion in the brine spaced apart, the oxidized body is produced by electrolyzing the brine by applying a current to the negative electrode portion and the positive electrode portion. The method of claim 10, The negative electrode portion and the positive electrode portion is a manufacturing method of physiological saline, characterized in that the projection formed so as to face each other. The method of claim 11, The protrusion is a manufacturing method of physiological saline, characterized in that the tip portion is formed sharply. The method of claim 11, The protrusion is a method of producing a physiological saline, characterized in that formed in the form of a column. The method of claim 11, The protrusion is a method of producing physiological saline, characterized in that formed of any one of platinum or titanium. The method of claim 11, The protrusion is a method of producing physiological saline, characterized in that the plated with any one of platinum or titanium.

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