KR20060013354A - The development of demineralized bone matrix by adding calcium phosphate cement - Google Patents
The development of demineralized bone matrix by adding calcium phosphate cement Download PDFInfo
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- KR20060013354A KR20060013354A KR1020050120497A KR20050120497A KR20060013354A KR 20060013354 A KR20060013354 A KR 20060013354A KR 1020050120497 A KR1020050120497 A KR 1020050120497A KR 20050120497 A KR20050120497 A KR 20050120497A KR 20060013354 A KR20060013354 A KR 20060013354A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
- A61L24/0063—Phosphorus containing materials, e.g. apatite
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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Abstract
본 발명은 골 형성을 유도하는 물질인 탈회골 기질(DBM : Dimeniralized Bone Matrix)분말에 있어서, 상기 탈회골 기질 분말의 적어도 전부 또는 일부를 인산칼슘계 시멘트로 대체한 탈회골-시멘트 복합 기질 조성물에 관한 것으로, 본 조성물은 600 kPa의 높은 압축강도와 경화시 발열이 억제되는 생체흡수성을 나타내므로 근골격계통의 질환치료에 사용되는 의료용 생체재료로 매우 유용하다.The present invention relates to a demineralized bone matrix (DBM: Dimeniralized Bone Matrix) powder, which is a substance that induces bone formation, wherein at least all or part of the demineralized bone matrix powder is replaced with calcium phosphate-based cement. The present composition is very useful as a medical biomaterial used in the treatment of diseases of the musculoskeletal system because it exhibits a high compressive strength of 600 kPa and bioabsorbability to suppress the heat generation during curing.
탈회골 기질, 인산칼슘계 시멘트, 압축강도, 발열 Demineralized bone matrix, calcium phosphate cement, compressive strength, exothermic
Description
본 발명은 탈회골 기질 (DBM : Demineralized Bond Matrix)에 관한 것으로서, 보다 구체적으로는 고강도이면서 생체흡수성이 우수한 탈회골 기질 - 시멘트 복합 조성물에 관한 것이다. The present invention relates to a demineralized bond matrix (DBM), and more particularly to a demineralized bone matrix-cement composite composition having high strength and excellent bioabsorbability.
탈회골 기질(DBM: Demineralized Bone Matrix)은 동종이식물(Allograft)로서 세포와 무기질을 제거하여 고분자로만 이루어진 물질을 의미하며, 경조직 재생을 유도하는 물질로서 다양한 분야로의 응용이 기대되는 물질이다. Demineralized Bone Matrix (DBM) is an allograft (Allograft), which refers to a substance composed of polymer only by removing cells and minerals, and is a substance that induces hard tissue regeneration and is expected to be applied to various fields.
DBM은 골재생능력이 뛰어나 주로 정형외과나 치과분야에서 골 재생이 느리거나 불가능한 부위에 충진재로 사용되고 있다. 또한 골 손실부의 치환, 관절 고정 강화에도 사용이 되며, 골 종, 골 외상, 골절 치료에도 사용되고 있다. 그러나 다양한 장점을 지닌 DBM has excellent bone regeneration ability and is mainly used as a filler in areas where bone regeneration is slow or impossible in orthopedic or dental fields. It is also used to replace bone loss, strengthen joint fixation, and to treat osteomas, bone trauma, and fractures. But with a variety of advantages
그러나 다양한 장점을 지닌 DBM에도 문제점이 없는 것은 아니다. 구조적 강도와 형태 유지의 부재로 더딘 골 생성이 되며 불완전한 대치가 될 단점이 있다. 또한 손상부위 주입시에 탈회골기질 자체내에는 주입성이 없기 때문에 다른 물질과의 연계가 필요하다. However, DBM with various advantages is not without problems. The lack of structural strength and shape retention results in slow bone formation and incomplete replacement. In addition, the injection of the damaged site, because the demineralized bone matrix itself is not injected, it is necessary to link with other substances.
현재까지의 보고에 의하면 탈회골 기질의 취약한 강도와 주입성을 향상시키기 위해서 젤라틴등을 혼합하는 방법이 개발되어 제품화되고 있다. 그러나 이러한 젤라틴등을 혼합하는 방식은 탈회골 기질의 주입성을 어느 정도 개선시킬 수는 있으나 체내에 주입 후 체액에 의해 형태 유지가 어렵고 강도가 낮아 형태를 장시간 지속치 못하는 단점을 가지고 있다. According to the report to date, a method of mixing gelatin and the like has been developed and commercialized to improve the weak strength and injectability of the demineralized bone matrix. However, the method of mixing such gelatin can improve the injection property of the demineralized bone matrix to some extent, but it is difficult to maintain the shape by the body fluid after injection into the body and has a low strength so that the shape cannot be maintained for a long time.
따라서 본 발명은 보다 향상된 강도를 갖는 탈회골 기질을 제공하는 것을 기술적 과제로 한다. Therefore, it is a technical object of the present invention to provide a demineralized bone matrix having more improved strength.
상기한 과제를 해결하기 위한 본 발명자의 연구에서 탈회골 기질(DBM : Dimeniralized Bone Matrix)분말의 제조과정에 있어서 상기 탈회골 기질 분말의 일부를 인산칼슘계 시멘트로 대체한 결과 인산칼슘계 시멘트의 함량 증가에 따라 600 kPa의 높은 압축강도와 경화시 발열이 억제되는 탈회골 기질을 제공할 수 있었고, 그 결과 본 발명을 완성하게 된 것이다.Content of calcium phosphate cement as a result of replacing part of the demineralized bone matrix powder with calcium phosphate cement in the manufacturing process of demineralized bone matrix (DBM) powder in the study of the present inventors to solve the above problems With increasing the high compressive strength of 600 kPa and it was possible to provide a demineralized bone substrate that suppresses the heat generation during hardening, as a result is to complete the present invention.
그러므로 본 발명에 의하면 골형성을 유도하는 물질인 탈회골 기질(DBM : Dimeniralized Bone Matrix)분말에 있어서, 상기 탈회골 기질 분말의 적어도 일부를 인산칼슘계 시멘트로 대체한 것을 특징으로 하는 탈회골-시멘트 복합 기질 조성물이 제공된다. Therefore, according to the present invention, in the demineralized bone matrix (DBM) powder, which is a substance that induces bone formation, at least a part of the demineralized bone matrix powder is replaced with calcium phosphate-based cement. A composite substrate composition is provided.
이하 본 발명을 보다 상세하게 설명하기로 한다. Hereinafter, the present invention will be described in more detail.
본 조성물은 탈회골 기질의 강도를 향상시키기 위해서 인산칼슘계 시멘트, 즉 트리칼슘포스페이트 분말로 구성된 인산칼슘계 시멘트를 사용하는 것을 특징으로 한다. The composition is characterized by using calcium phosphate cement composed of calcium phosphate cement, ie tricalcium phosphate powder, in order to improve the strength of the demineralized bone matrix.
일반적으로 탈회골기질은 골재생능력이 뛰어나 주로 정형외과나 치과분야에서 골 재생이 느리거나 불가능한 부위에 충진재로 사용되고 있다. 본 발명에 따라 인산칼슘계 시멘트를 사용하게 되면 DBM보다 상대적으로 고강도인 재료가 복합첨가되는 것이므로 그 결과 제조되는 탈회골 기질- 시멘트의 강도를 크게 향상시킬 수 있다. 또한 시멘트로 인해 유동성이 부여되면서도 경화반응시 나타날 수 있는 발열 현상역시 크게 제어할 수 있다. In general, demineralized bone matrix is used as a filler in areas where bone regeneration is slow or impossible in orthopedic or dental fields due to its excellent bone regeneration ability. When the calcium phosphate-based cement is used according to the present invention, since a material having a relatively higher strength than that of DBM is added to the compound, the strength of the resulting demineralized bone matrix-cement can be greatly improved. In addition, while exerted fluidity due to cement, the exothermic phenomenon that can appear during the curing reaction can also be greatly controlled.
종래, 탈회골 기질의 취약한 강도와 주입성을 향상시키기 위해서 젤라틴등을 혼합 하는 방법이 개발되어 제품화되고 있다. 그러나 이러한 젤라틴등을 혼합하는 방식은 탈회골 기질의 주입성을 어느 정도 개선시킬 수는 있으나 체내에 주입 후 체액에 의해 형태 유지가 어렵고 강도가 낮아 형태를 장시간 지속치 못하는 단점을 가지고 있다. Conventionally, in order to improve the weak strength and injectability of the demineralized bone matrix, a method of mixing gelatin and the like has been developed and commercialized. However, the method of mixing such gelatin can improve the injection property of the demineralized bone matrix to some extent, but it is difficult to maintain the shape by the body fluid after injection into the body and has a low strength so that the shape cannot be maintained for a long time.
따라서, 본 발명에 의하면 탈회골 기질의 강도를 획기적으로 증가시킬 뿐 아니라 주입성 역시 훼손되지 않고 보존할 수 있으며 채내에 주입 후에도 그 형태를 장시간 지속시킴으로써 탈회골 기질의 기능 강화를 가져올 수 있다. Therefore, according to the present invention, not only can dramatically increase the strength of the demineralized bone matrix, but also the injectability can be preserved without being impaired, and the form of the demineralized bone matrix can be strengthened by sustaining the form for a long time even after infusion.
이상 설명한 바와 같은 본 발명의 특징 및 기타 장점은 후술되는 실시예로부터 보다 명백하게 될 것이다. 단, 본 발명이 하기 실시예로 제한되는 것은 아니다. Features and other advantages of the present invention as described above will become more apparent from the following examples. However, the present invention is not limited to the following examples.
[실시예1]Example 1
* *
상술한 바와 같이, 인산칼슘계 시멘트를 함유한 본 발명의 탈회골 기질-시멘트 복합 조성물은 600kPa 이상의 높은 압축강도와 함께 경화시 발열이 억제되는 생체흡수성을 나타내므로, 근골격계통의 질환치료등에 사용되는 의료용 생체 재료로 매우 유용하다.As described above, the demineralized bone matrix-cement composite composition of the present invention containing calcium phosphate-based cement has high compressive strength of 600 kPa or more and exhibits bioabsorption of heat generation upon curing, and thus is used for treating diseases of the musculoskeletal system. Very useful as a medical biomaterial.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9701630B2 (en) | 2012-07-19 | 2017-07-11 | Cayman Chemical Company, Inc. | Difluorolactam compositions for EP4-mediated osteo related diseases and conditions |
| US10729810B2 (en) | 2013-07-19 | 2020-08-04 | Cayman Chemical Company, Inc | Methods, systems, and compositions for promoting bone growth |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9701630B2 (en) | 2012-07-19 | 2017-07-11 | Cayman Chemical Company, Inc. | Difluorolactam compositions for EP4-mediated osteo related diseases and conditions |
| US11066361B2 (en) | 2012-07-19 | 2021-07-20 | Cayman Chemical Company, Inc. | Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions |
| US11884624B2 (en) | 2012-07-19 | 2024-01-30 | Cayman Chemical Company, Inc. | Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions |
| US10729810B2 (en) | 2013-07-19 | 2020-08-04 | Cayman Chemical Company, Inc | Methods, systems, and compositions for promoting bone growth |
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