KR20050055643A - Diet agent containing chitosan microparticle and the preparation method thereof - Google Patents

Abstract

The present invention relates to an obesity inhibitor containing chitosan and a diet food comprising the same as an active ingredient, and more particularly, to reprocess chitosan in the form of fine particles so as to quickly dissolve high molecular weight chitosan in the stomach and to produce the chitosan fine particles and organic acids. And an obesity inhibitor containing sucrose and a diet food comprising the same as an active ingredient.

Description

Diet agent containing chitosan microparticle and the preparation method

The present invention relates to an obesity inhibitor containing chitosan and a diet food comprising the same as an active ingredient, more specifically 20 to 60% by weight of chitosan fine particles, 20 to 40% by weight of organic acids, 20 to 40% by weight of subsidiary materials such as sucrose It relates to inhibiting obesity containing and diet foods having the same as an active ingredient.

As the diet tends to become westernized recently, obesity, especially abdominal obesity, has become a serious social problem as the consumption of high calorie foods increases and fiber intake decreases. Obesity refers to a state in which fat tissue is excessively increased, and weight gain due to obesity is mostly due to an increase in fat.

Obesity is known to cause all kinds of complications such as cancer, arteriosclerosis, heart disease, high blood pressure, diabetes and other complications, and in 1996, the World Health Organization (WHO) warned that obesity is a disease that needs treatment. In addition, obesity is often caused by constipation, indigestion, gastrointestinal disorders due to the abdominal pressure by the fat tissue.

In order to suppress obesity and improve constipation, it is important to reduce the body's accumulation of fat by reducing the consumption of food, especially high-calorie foods, and increasing energy consumption. In particular, increasing energy consumption rather than reducing food intake is known to be effective in suppressing obesity. Regular exercise has also been shown to increase energy consumption and significantly reduce mortality from cardiovascular disease. However, due to the characteristics of modern society, which is difficult to continuously exercise, the main efforts to control obesity are focused on the consumption of diet foods or health supplement foods that are effective in suppressing obesity and improving constipation.

Many foods are known to have anti-obesity and constipation-improving effects. For example, capsaicin contained in red pepper is known to promote lipolysis by oxidative exothermic reactions, and it has been reported that intake of dietary fiber, such as satiety, reduces food intake.

Chitosan has little toxicity even when administered orally to animals, and bacteria in the intestines are improved, and it is combined with chlorine ions or bile acids to excrete them in vitro to lower serum cholesterol and lower blood pressure. Research on the antimicrobial activity of chitosan is known to inhibit the growth of Escherichia coli and staphylococci.

Chitosan is known to suppress the absorption of cholesterol by adsorbing and absorbing fat to be discharged to the outside of the body and by adsorbing and discharging bile acid.

The present invention relates to an obesity inhibitor containing chitosan and a diet food comprising the same as an active ingredient, and more particularly, to prepare chitosan microparticles so as to quickly dissolve high molecular weight chitosan in the stomach, and to prepare the chitosan microparticles, organic acids and sucrose. It relates to inhibiting obesity containing and diet foods having the same as an active ingredient.

The present invention relates to an obesity inhibitor containing chitosan and a diet food comprising the same as an active ingredient, and more particularly, to reprocess chitosan in the form of fine particles so as to quickly dissolve high molecular weight chitosan in the stomach and to produce the chitosan fine particles and organic acids. And an obesity inhibitor containing sucrose and a diet food comprising the same as an active ingredient.

In the present invention, chitosan is preferably a high viscosity chitosan having a viscosity of 100 cps or more, preferably a chitosan having a viscosity of 700 cps or more, and more preferably 1000 cps or more. The degree of deacetylation is preferably 80% or more and more preferably chitosan having a degree of deacetylation of 90% or more.

The rate of dissolution by gastric juice in the stomach when ingested chitosan greatly affects the amount of fat adsorption, thus preparing chitosan into fine particles. In this way, the crystal structure of chitosan was dismantled and the dissolution rate was greatly increased by expanding the contact area with the gastric juice.

The method for preparing the fine particles of chitosan is dissolved in chitosan in 1 to 5% by weight of acetic acid or hydrochloric acid solution at 0.5 to 10% by weight, and stirred at 1000rpm to 1500rpm, while adding sodium hydroxide and hydroxide in the equivalent ratio of acetic acid or hydrochloric acid solution. 2 to 50 μm of chitosan microparticles were prepared by neutralizing the solution with potassium, ammonia water, and the like to pH 6.8 to 7.5 to gel the gel, washing the gel solution sufficiently to remove salt, and freeze drying or spray drying. The solubility for 1 minute in 0.16N hydrochloric acid solution, such as the concentration of gastric juice of the particulate flakes, was found to be very high solubility compared to Chinese chitosan, high viscosity chitosan high viscosity chitosan, as shown in Table 1. The adsorption rate was also very high.

Chinese high viscosity Midland Tokitosan High kurtosis chitosan Particulate chitosan Solubility (%) in 0.16N (dissolution time: 1 minute) 18 40 35 96 Fat adsorption rate (%) 8 15 20 95

Chitosan microparticles prepared as described above use 20 to 60% by weight based on the total diad agent.

The organic acid used in the present invention may be an organic acid such as ascorbic acid, citric acid, lactic acid, glutamic acid, gluconic acid, tartaric acid, but it is preferable to use ascorbic acid, lactic acid, citric acid from the viewpoint of diet effect. It is preferable to use 20-40 weight% of usage-amount.

As other materials, 20 to 40% by weight of materials such as sucrose may be used.

Specific manufacturing method according to the above is as follows.

Example 1-4, Comparative Example

In order to measure the diet characteristics of the diet containing chitosan fine particles, the following Po1 was carried out.

Example 1 Example 2 Example 3 Example 4 Comparative example cellulose - - 60 Chitosan fine particles 60 50 50 50 Ascorbic acid 30 Chopsan 30 Citric acid 30 Sucrose 40 20 20 20 40 Etc - - - - -

Example 5

  Rats weighing 130-150 grams were controlled in groups of 10 (day-to-day) at 22 ± 1 ° C, with 12-day intervals of day and night controls, cellulose administration, chitosan microparticles, chitosan microparticles and ascorbic acid, chitosan microparticles and lactose and chitosan. Dividing into particulate + citric acid group was carried out diet characteristics for 5 days.

Example Feeding amount (g / day) Excretion (dry) (g / mice / 3days) Lipids in Embryos (mg / g) One 13.2 +/- 0.4 8.329 +/- 0.563 492.0 +/- 28.7 2 14.8 +/- 0.9 12.70 +/- 0.942 555.3 +/- 18.6 3 13.0 +/- 0.4 6.773 +/- 0.684 424.8 +/- 50.4 4 12.5 +/- 0.5 7.168 +/- 0.947 408.6 +/- 46.9 Comparative example 15.7 ± 22.1 4.13 +/- 0.569 115.2 +/- 5.6

Table 2 above shows the amount of feed, the amount of excretion in the liver and the amount of fat in the excreta during the experiment. In the case of the feeding amount, it can be seen that Example 4 is less eaten compared to the control, and the rest is eaten slightly less than the control, but showed similar amounts. In the amount of excretion showed a much larger amount of excretion than the control, the administration of chitosan microparticles and Example 2 showed a particularly large amount of excretion. In addition, the amount of lipid (LIPID) in the excretion amount of the experimental group was very high compared to the control, but in particular Example 1 and Example 2 was about 5 times the amount. The above experiment shows a very good diet characteristics, especially chitosan microparticles and ascorbic acid mixture showed a very good diet effect.

Obesity is known to cause all kinds of complications such as cancer, arteriosclerosis, heart disease, high blood pressure, diabetes and other complications, and in 1996, the World Health Organization (WHO) warned that obesity is a disease that needs treatment.

Therefore, the present invention is very effective as a dietary supplement without the yo-yo phenomenon as an effective health food for obesity relief.

Claims (4)

The present invention relates to an obesity inhibitor containing chitosan and a diet food using the same as an active ingredient, wherein the chitosan is reprocessed in the form of fine particles to rapidly dissolve high molecular weight chitosan in the stomach, and the chitosan fine particles, organic acid and sucrose are included. Obesity suppression and diet foods with the active ingredient. [Claim 2] The chitosan has a viscosity of at least 100 cps and a degree of deacetylation of at least 80%. It is neutralized by adding sodium hydroxide, potassium hydroxide, and ammonia water in an equivalence ratio of acetic acid or hydrochloric acid solution to gel it. Inhibition and diet foods using the same as an active ingredient. The organic acid used in claim 1 is an obesity inhibitor and an active ingredient characterized in that it uses an organic acid of ascorbic acid, citric acid, lactic acid, glutamic acid, gluconic acid, tartaric acid. The dietary food according to claim 1, wherein the chitosan fine particles are 20 to 60% by weight, organic acids are 20 to 40% by weight, and sucrose to 20 to 40% by weight.