KR20050016447A - Cosmetic compositions with ammonium malonates - Google Patents

Abstract

There is provided a cosmetic composition comprising as salt the salt formed by neutralization of malonic acid to ammonia or C1-C10 hydrocarbyl amine, the composition having a pH in the range of 1.8 to 6.5. Particularly preferably ammonium malonate.

Description

Cosmetic composition containing ammonium malonate {COSMETIC COMPOSITIONS WITH AMMONIUM MALONATES}

The present invention relates to a cosmetic composition comprising ammonium malonate that prevents signs of skin aging.

Soft, supple and elastic skin has a strong aesthetic appeal because the epidermis functions normally. As human skin ages as it ages, the epidermis may fold, bend or wrinkle, resulting in the formation of wrinkles. This is a sign of the loss of young appearance and heralds the transition to old age. Excessive sun exposure promotes this transition process. In addition, the outer layer of the epidermis, known as the stratum corneum, may dry and exfoliate after exposure to cold weather or excessive contact with detergents or solvents. This causes skin moisture loss, and the skin begins to lose its soft, supple and elastic properties.

In the past, emollients such as fats, phospholipids and sterols have been used to soften wrinkled or dry skin. These emollients are only partially effective as a remedy for poor skin.

Use of hydroxy carboxylic acids to improve the condition of human skin is known. There is no doubt that alpha-hydroxy carboxylic acids are much more effective than common emollients.

US Pat. No. 4,424,234 (Alderson et al.) Discloses a skin treatment composition comprising alpha-hydroxycaproic acid and alpha-hydroxycarfilic acid or mixtures thereof in a composition having a pH value of less than 7, usually 2-4. Initiate. Yu and Van Scott have extensively patented this field. For example, US Pat. No. 4,105,782 reports amine or ammonium salts of alpha-hydroxy carboxylic acids for treating acne or dandruff. US 4,105,783 and US 4,197,316 propose these compounds for the treatment of dry skin. U.S. Patent 4,234,599 discloses the use for the treatment of keratosis of alpha-hydroxy carboxylic acids, esters thereof or amine salts thereof. More recently, attention has been focused in US Pat. No. 5,091,171 that these compounds are effective against skin changes associated with blotch, wrinkles and aging.

Hydroxy carboxylic acids have many therapeutic possibilities, but repeated application of this substance has been found to irritate human skin. Such irritation may range from feeling of tingling, itching and burning to clinical signs of erythema and peeling. The cause of such irritation is associated with a drop in pH of the stratum corneum of human skin. Low pH suggests confusion in the binding of keratinocytes, leading to negative skin reactions, especially in certain individuals with sensitive skin.

Organic acids other than alpha-hydroxy functionalization have been disclosed in the cosmetic literature. For example, US Pat. No. 5,641,495 (Jokura et al.) Discloses a mixture of ceramides or pseudoceramides, dicarboxylic acids and dicarboxylic acid salts. The examples illustrate the sodium and potassium salts of succinic acid.

Lower molecular weight dicarboxylic acids such as malonic acid may also be used.

Although accompanied by good moisturizing and less stimulation, it has not been proposed that such a system prevents signs of aging such as the appearance of fine lines and wrinkles. Advances in overall skin anti-aging technology still do not meet consumer demand.

It is therefore an advantage of the present invention that a novel cosmetic ingredient composition can be provided that is effective in inhibiting or even eliminating the signs of aging, in particular fine lines, wrinkles, sagging skin, poor skin color and blotch.

A first aspect of the invention is:

(i) about 0.0001% to about 30% by weight of a salt that is amine neutralized malonic acid;

(ii) providing a cosmetic composition comprising from about 1% to about 99.9% by weight cosmetically acceptable carrier and having a pH in the range from about 1.8 to 6.5.

We have come to the present invention and found a class of salts that is at least as effective as alpha-hydroxy carboxylic acid. These salts are based on malonic acid neutralized with an amine which is ammonia or C ₁ -C ₁₀ hydrocarbyl amine as the active salt component. These salts may be half or fully neutralized malonate salts or mixtures thereof represented by the following formula (I) or (II):

[HO ₂ CCH ₂ CO ₂ ] ^- [X] ⁺

⁺ [X] ₂ [O ₂ CCH ₂ CO ₂ ] ^-2

In the above formulas, X is protonated ammonia or C ₁ -C ₁₀ hydrocarbyl amine.

Examples of amines are ammonia, triethanolamine, diethanolamine, monoethanolamine, methylamine, ethylamine, propylamine, isopropylamine, butylamine, isobutylamine, t-butylamine, pentylamine, isopentylamine, hexyl Amines, cyclohexylamine, cyclopentylamine, norbornylamine, octylamine, ethylhexylamine, nonylamine, decylamine and mixtures thereof. Most preferred is ammonia which forms the ammonium salt of malonate and comprises ammonium malonate and diammonium malonate.

The amount of amine neutralizing malonic acid salt is from about 0.0001% to about 30% by weight of the cosmetic composition, preferably from about 0.1% to about 15% by weight, more preferably from about 0.5% to about 10% by weight, optimally about It may range from 1% to about 8% by weight.

The present invention can utilize salt I, salt II or mixtures of these salts as the active ingredient. When present in the mixture, the molar ratio of mono-salt I to di-salt II is from about 1000: 1 to about 1: 1000, preferably from about 10: 1 to about 1: 500, more preferably from about 2: 1 to About 1: 200, optimally about 1: 1 to about 1:20.

The compositions of the present invention may have a pH in the range of about 1.8 to about 6.5, preferably about 2.5 to about 6, optimally about 3 to about 5.5, more optimally about 3.5 to about 4.5.

The composition of the present invention will also include a cosmetically acceptable carrier. The amount of carrier may range from 1% to 99.9%, preferably from about 70% to about 95%, optimally from about 80% to about 90%. Useful carriers are water, emollients, fatty acids, fatty alcohols, humectants, thickeners and mixtures thereof. The carrier may be aqueous, anhydrous or emulsion. Preferably the composition is an emulsion of water and oil in water, in particular in the form of W / O or O / W. If present, the amount may range from about 5% to about 95% by weight, preferably from about 20% to about 70% by weight, optimally from about 35% to about 60% by weight.

Softener materials may serve as cosmetically acceptable carriers. These may be in the form of silicone oils, synthetic esters and hydrocarbons. The amount of emollient may range from about 0.1% to about 95% by weight, preferably from about 1% to about 50% by weight.

Silicone oils can be divided into volatile and nonvolatile classes. As used herein, the term “volatile” refers to a material having a vapor pressure that can be measured at ambient temperature. The volatile silicone oil is preferably selected from cyclic (cyclomethicone) or linear polydimethylsiloxanes having 3 to 9, preferably 4 to 5 silicon atoms.

Nonvolatile silicone oils useful as emollient materials include polyalkyl siloxanes, polyalkylaryl siloxanes, and polyether siloxane copolymers. Intrinsically nonvolatile polyalkyl siloxanes useful in the present invention include, for example, polydimethyl siloxanes having a viscosity of about 5 × 10 ⁻⁶ to 0.1 m ² / s at 25 ° C. Preferred nonvolatile softeners useful in the compositions of the present invention are polydimethyl siloxanes having a viscosity of about 1 × 10 ⁻⁵ to about ⁴ × 10 ⁻⁴ m ² / s at 25 ° C.

Another class of nonvolatile silicones are emulsified and non-emulsified silicone elastomers. Representative of this class are the dimethicone / vinyl dimethicone crosspolymers available as Dow Corning 9040, General Electric SFE 839 and Shin-Etsu KSG-18. Silicone waxes such as Silwax WS-L (dimethicone copolyol laurate) will also be useful.

Suitable ester softeners are as follows:

(1) Alkenyl or alkyl esters of fatty acids having 10 to 20 carbon atoms. Examples thereof include isoarachidyl neopentanoate, isononyl isonanonoate, oleyl myristate, oleyl stearate and oleyl oleate.

(2) ether esters, such as fatty acid esters of ethoxylated fatty alcohols.

(3) polyhydric alcohol esters. Ethylene glycol mono- and di-fatty acid esters, diethylene glycol mono- and di-fatty acid esters, polyethylene glycol (200-6000) mono- and di-fatty acid esters, propylene glycol mono- and di-fatty acid esters, polypropylene glycol 2000 Monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol poly-fatty esters, ethoxylated glyceryl mono-stearate, 1,3- Butylene glycol monostearate, 1,3-butylene glycol distearate, polyoxyethylene polyol fatty acid esters, sorbitan fatty acid esters and polyoxyethylene sorbitan fatty acid esters are satisfactory polyhydric alcohol esters. Particularly useful are neopentyl glycol esters of pentaerythritol, trimethylolpropane and C ₁ -C ₃₀ alcohols.

(4) wax esters such as beeswax, meridians and tribehenin waxes.

(5) Sterol esters and cholesterol fatty acid esters are examples.

(6) sugar esters of fatty acids such as sucrose polybehenate and sucrose polycottondate.

Suitable hydrocarbons as cosmetically acceptable carriers are petrolatum, mineral oil, C ₁₁ -C ₁₃ isoparaffin, polyalphaolefins and isohexadecane, which can be purchased in particular Permethyl 101A from Presperse Inc. It includes.

Fatty acids having 10 to 30 carbon atoms may also be suitable as cosmetically acceptable carriers. Examples thereof include pelagonic acid, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, hydroxystearic acid, oleic acid, linoleic acid, ricinoleic acid, arachidic acid, behenic acid and e. It is luc acid.

Fatty alcohols having 10 to 30 carbon atoms are another class of useful cosmetically acceptable carriers. Examples of this kind are stearyl alcohol, lauryl alcohol, myristyl alcohol and cetyl alcohol.

Moisturizers of the polyhydric alcohol type can also be used as cosmetically acceptable carriers. Typical polyhydric alcohols are glycerol, polyalkylene glycols, more preferably alkylene polyols and derivatives thereof such as propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, hex Ylene glycol, 1,3-butylene glycol, isoprene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and mixtures thereof. The amount of humectant may range from 0.5% to 50%, preferably 1% to 15% by weight of the composition.

 Thickeners can also be used as part of the cosmetically acceptable carrier of the compositions according to the invention. Typical thickeners include crosslinking acrylates (eg Carbopol 982®), hydrophobic-modified acrylates (eg carbopol 1382®), cellulose derivatives and natural rubber do. Useful cellulose derivatives are sodium carboxymethylcellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, ethyl cellulose and hydroxymethyl cellulose. Natural rubbers suitable for the present invention include guar, xanthan, sclerotium, carrageenan, pectin and mixtures of these rubbers. Inorganic materials can also be used as thickeners, in particular clays such as bentonide and hectorite, fumed silica and silicates such as magnesium aluminum silicate (Veegum®). The amount of thickener may range from 0.0001% to 10% by weight, usually from 0.001% to 1% by weight, optimally from 0.01% to 0.5% by weight.

The cosmetic composition of the present invention may be in any form. These forms may include lotions, creams, rotatable formulations, sticks, mousses, aerosols and non-aerosol sprays and pad application formulations.

Surfactants may also be present in the cosmetic compositions of the invention. The total concentration when the surfactant is present can range from about 0.1% to 40%, preferably from about 1% to about 20%, optimally from about 1% to about 5% by weight of the composition. The surfactant can be selected from the group consisting of anionic, nonionic, cationic and amphoteric actives.

Particularly preferred nonionic surfactants include those of C ₁₀ -C ₂₀ fatty alcohols or acid hydrofobs condensed with 2 to 100 moles of ethylene oxide or propylene oxide per mole of hydrophobe; C ₂ -C ₁₀ alkyl phenols condensed with 2 to 20 moles of alkylene oxide; Mono- and di-fatty acid esters of ethylene glycol; Fatty acid monoglycerides; Sorbitan, mono- and di-C ₈ -C ₂₀ fatty acids; And polyoxyethylene sorbitan and mixtures thereof. Alkyl polyglycosides and saccharide fatty amides (eg methyl gluconamide) are also suitable nonionic surfactants.

Preferred anionic surfactants include soap, alkyl ether sulfate and sulfonates, alkyl sulfates and sulfonates, alkylbenzene sulfonates, alkyl and dialkyl sulfosuccinates, C _8- C ₂₀ acyl isethionates, C ₈ - C ₂₀ alkyl ether phosphate, C ₈ -C ₂₀ sarcosinate and mixtures thereof.

Sunscreen activators may also be included in the compositions of the present invention. Particularly preferred are ethylhexyl p-methoxycinnamate, available under Parsol MCX®, benzophenone-3, also known as abobenzene and oxybenzone, available under Parsol 1789®. Is the same substance. Inorganic sunscreen actives such as ultrafine titanium dioxide, zinc oxide, polyethylene and various other polymers can be used. When present, sunscreen agents may generally range from 0.1% to 30% by weight, preferably from 2% to 20% by weight, optimally from 4% to 10% by weight.

Preferably preservatives for preventing the growth of potentially harmful microorganisms may be included in the cosmetic composition of the present invention. Typical preservatives suitable for the compositions of the present invention are alkyl esters of para-hydroxybenzoic acid. Other preservatives that have been used more recently include hydantoin derivatives, propionate salts and various quaternary ammonium compounds. Cosmetic chemists are familiar with the appropriate preservatives and can routinely choose a supplement to meet preservative induced tests and provide product stability. Particularly preferred preservatives are phenoxyethanol, methyl paraben, propyl paraben, imidazolidinyl urea, sodium dehydroacetate and benzyl alcohol. Preservatives should be selected taking into account the use of the composition and possible incompatibility between the preservative and the other ingredients in the emulsion. Preservatives are preferably used in amounts ranging from 0.01% to 2% by weight of the composition.

The composition of the present invention may comprise a vitamin. Examples of vitamins are vitamin A (retinol), vitamin B ₂ , vitamin B ₆ , vitamin C, vitamin E and biotin. Derivatives of vitamins can also be used. For example, vitamin C derivatives include ascorbyl tetraisopalmitate, magnesium ascorbyl phosphate and ascorbyl glycosides. Vitamin E derivatives include tocopheryl acetate, tocopheryl palmitate and tocopheryl linoleate. DL-panthenol and derivatives can also be used. The total amount of vitamin when present in the composition according to the invention may range from 0.001% to 10% by weight, preferably from 0.01% to 1% by weight, optimally from 0.1% to 0.5% by weight.

Another type of useful substance may be an enzyme such as oxidases, proteases, lipases and mixtures.

Particularly preferred is superoxide dismutase, commercially available as a Biocell SOD from Brooks Company, USA.

Skin lightening compounds can be included in the compositions of the present invention. Examples of substances are placenta extract, lactic acid, niacinamide, arbutin, kojic acid, ferulic acid, resorcinol and derivatives comprising 4-substituted resorcinol and mixtures thereof. The amount of these materials may be from about 0.1% to about 10%, preferably from about 0.5% to about 2% by weight of the composition.

Peeling accelerators may also be present. For example alpha-hydroxycarboxylic acid and beta-hydroxycarboxylic acid. The term “acid” means not only the free acid but also the lactone prepared by removing its salt and its C ₁ -C ₃₀ alkyl or aryl ester and water to form a cyclic or linear lactone structure. Representative acids are glycols, lactic and malic acid. Salicylic acid is a representative beta-hydroxycarboxylic acid. If these materials are present, the amount may range from about 0.1% to about 15% by weight of the composition.

Various herbal extracts may optionally be included in the compositions of the present invention. For example, it is a mixture of green tea, chamomile, licorice and extract. The extract may be included as water-soluble or water-insoluble in a solvent that is hydrophilic or hydrophobic, respectively. Water and ethanol are the preferred extract solvents.

Lipoic acid, retinoxytrimethylsilane (available under the Silcare 1M-75 trade name from Clariant Corp.), ceramide (Ceramide 1, Ceramide 3, Ceramide 3B and Ceramide 6). Dehydroepiandrosterone (DHEA) and mixtures thereof. The amount of these materials may range from about 0.000001% to about 10% by weight, preferably from about 0.0001% to about 1% by weight.

Coloring agents, fragrances, milking agents and abrasives may also be included in the compositions of the present invention. Each of these materials may range from about 0.05% to about 5% by weight, preferably 0.1% to 3% by weight.

The term "comprising" means to include not only the elements mentioned next, but also elements of major or additional functional significance not mentioned. That is, it is not necessary to list the steps, elements or options to be written one after another. When the word "having" is used, this term has the same meaning as "comprising" as described above.

Except for the examples and comparative examples, or unless otherwise noted, all numbers indicative of the amount of substance herein should be understood to be modified by the word "about."

The following examples are intended to illustrate embodiments of the invention in more detail. All parts, percentages, and ratios mentioned in the examples and appended claims are by weight unless otherwise specified.

Example 1

Clinical studies were performed to compare ammonium malonate as an active cosmetic ingredient with ammonium glycolate. The base formulations for the comparative experiments are summarized in Table I below.

ingredient weight% Phase A water Remainder Disodium EDTA 0.05 Methyl paraben 0.15 Magnesium aluminum silicate 0.60 Triethanolamine 1.20 Phase B Xanthan rubber 0.20 Natrosol® 250HHR (ethyl cellulose) 0.50 Butylene Glycol 3.00 glycerin 2.00 Phase C Sodium stearoyl lactylate 0.10 Glycerol Monostearate 1.50 Stearyl alcohol 1.50 Isostearyl Palmitate 3.00 Silicone fluid 1.00 cholesterol 0.25 Sorbitan stearate 1.00 Butylated Hydroxy Toluene 0.05 Vitamin E Acetate 0.01 PEG-100 Stearate 2.00 Stearic acid 3.00 Profile paraben 0.10 Parsol MCX (registered trademark) 2.00 Capryl / Capric Triglyceride 0.50 Hydroxycaprylic acid 0.01 C12-C15 alkyl octanoate 3.00 Phase D Active agent - Phase E Vitamin A Palmitate 0.10 Bisabolol 0.01 Vitamin A Acetate 0.01 Spices 0.03 Retinol 50C 0.02

The entire formulation comprising ammonium glycolate and ammonium malonate activator is described as "PADC" and "ammonium" in the table below. PADC products are the latest alpha hydroxy acid formulations on the market. This formulation contained 8% or 0.1053 equivalents of glycolic acid neutralized with 0.395 equivalents of 2.4% ammonium hydroxide such that the pH of the final formulation was 3.8. The ammonia blend included 5.04% or 0.0969 equivalents of malonic acid neutralized with 0.0311 equivalent of 1.87% ammonia such that the pH of the final formulation was 3.6-4.0. This allowed malonic acid to be 31.87% neutralized by the amine.

The clinical study included 49 panelists in six weeks. Panelists let each product be applied to half of the face. After application, panelists were asked to answer a series of questions regarding the relative efficacy of the product.

product: 1 week (n = 49) 3 weeks (n = 49) 6 weeks (n = 47) PADC & Ammonium Malonate pH 3.6-4.0 PADC ammonium No preference PADC ammonium No preference PADC ammonium No preference More easily absorbed 31 39 30 35 29 37 30 23 47 Feeling less slippery 26 43 31 31 33 37 30 30 40 Feel lighter 33 39 28 35 35 31 32 34 34 Left skin feels softer 24 22 54 29 18 53 30 15 55 Softer 20 37 43 29 20 51 28 26 45 Left skin feels smoother 24 22 54 29 12 59 32 13 55 Left skin looks smoother 22 15 63 27 14 59 28 19 53 Moist 28 26 46 33 14 53 21 13 66 Make it look more elastic / tense 26 22 52 22 16 61 26 15 59 Makes you feel healthier 19 13 69 22 10 67 23 13 64 Makes you feel more elastic / tense 24 24 52 22 25 53 25 19 57 Better skin color 20 11 69 22 12 65 24 17 59 Makes skin look better 20 17 63 25 10 65 25 13 62 Better condition 20 19 61 20 16 63 28 15 57 Make you look younger 20 13 67 20 14 65 23 11 66 Left skin is more radiant 17 17 67 14 12 74 13 15 72 Was it less irritating? 23 36 41 26 25 49 28 30 42 Did you have a bad skin tone / feel in the evening? 15 9 76 18 10 71 21 9 70 More elastic skin 24 19 57 20 20 59 28 19 53 Overall preference Product: PADC & Ammonium Malonate pH3.6-4.0 1 week 3 weeks 6 Weeks PADC ammonium No preference PADC ammonium No preference PADC ammonium No preference Overall preference 41 33 26 35 37 29 36 34 30

Based on clinical evaluation results, it was evident that ammonium malonate was nearly as effective as ammonium glycolate, an almost known but stimulating inducer, in improving the overall condition of the skin.

In addition, more extensive clinical studies have found that ammonium malonate is less irritating than ammonium glycolate compositions. The results of the study are summarized in the table below. The products evaluated here were the same as those in the first clinical study.

Experiencing the whole skin issue product 1 week 4 Weeks 8 Weeks PADC Ammonium malonate PADC Ammonium malonate PADC Ammonium malonate Yes 24% 11% 10% 5% 9% 5% no 76% 89% 90% 95% 91% 95%

The types of skin problems experienced have been reported: any redness / spots, acne, tingling, burning, dryness, tingling, itching, irritation / discomfort, bumps, rashes, skin peeling, swelling, flaking, peeling, tightening, Blotch, blister / blister and any similar signs. Approximately 100 panelists participated in this clinical study. In the first week of use, ammonium malonate caused much less facial discomfort than ammonium glycolate. After a few weeks of use, the panelists became accustomed and the differences between the materials were still felt but less.

Example 2

Water-in-oil topical liquid make-up foundations using the malonate salts of the invention are described in Table IV below.

ingredient weight% Phase A Cyclomethicone 9.25 Cetyl octanoate 2.00 Dimethicone Copolyol 20.00 Phase B Talc 3.38 Pigment (iron oxide) 10.51 Spheron L-1500 (Silica) 0.50 Phase C Synthetic Wax Durachem 0602 0.10 Arachidil Behenate 0.30 Phase D Cyclomethicone 1.00 Trihydroxystearin 0.30 Phase E Laureth-7 0.50 Profile paraben 0.25 Phase F Spices 0.05 Phase G water Remainder Ammonium malonate 3.00 Methyl paraben 0.12 Propylene glycol 8.00 Niacinamide 4.00 glycerin 3.00 Sodium chloride 2.00 Sodium dehydroacetate 0.30

Example 3

Herein is described a skin cream comprising the malonate salt of the present invention.

ingredient weight% glycerin 6.93 Niacinamide 5.00 Ammonium malonate 5.00 Permethyl 101A ¹ 3.00 Sepigel 305 ² 2.50 Q2-1403 ³ 2.00 Isopropyl Isostearate 1.33 Arlatone 2121 ⁴ 1.00 Cetyl Alcohol CO-1695 0.72 SEFA Cottonnate ⁵ 0.67 Tocopherol acetate 0.50 Panthenol 0.50 Stearyl alcohol 0.48 Titanium dioxide 0.40 Disodium EDTA 0.10 Glydant Plus ⁶ 0.10 PEG-100 Stearate 0.10 Stearic acid 0.10 Purified water Remainder ¹ iso-hexadecane, Perth press Inc., NJ, USA, the South Plainfield ² Polyacrylamide (and) C13-14 isoparaffin (and) laureth-7, sepik Corporation (Seppic Corporation), Fairfield, NJ ³ Dimethicone (and) Dimethiconol, Dow Corning Corp. Midland, Michigan, USA. ⁴ sorbitan monostearate and sucrocoate, ICI Americas Inc., sucrose ester of Wilmington ⁵ , Delaware, USA ⁶ DMDM hydantoin (and) iodopropynyl butylcarbamate, Lonza Inc., Fairlon, NJ, USA

Example 4

A description of the powder cosmetic composition according to the invention is given in the formulation of Table VI below.

ingredient weight% Polysilicon-11 22.5 Cyclomethicone 59 vaseline 11 Ammonium Malonate (50% in water) 7 Dimethicone Copolyol 0.5

Example 5

Relatively anhydrous compositions according to the invention are listed in Table VII below.

ingredient weight% Cyclomethicone 80.65 Dimethicone 9.60 Squalene 6.00 Isostearic acid 1.90 Bored seed oil 0.90 Ammonium Malonate (50% in water) 0.50 Retinyl palmitate 0.25 Ceramide 6 0.10 Tocopherol 0.10

Example 6

Aerosol packaged foaming cleanser suitable for the present invention is summarized in Table VIII below.

ingredient weight% Sunflower seed oil 20.00 Maleated Soybean Oil 5.00 Silicone urethane 1.00 Polyglycero-4 Oleate 1.00 Sodium C14-16 Olefin Sulfonate 15.00 Sodium Lauryl Ether Sulfate (25% active) 15.00 Cocoamidopropylbetaine 15.00 DC 1784 (registered trademark) (50% of silicone emulsion) 5.00 Polyquaternium-11 1.00 Ammonium malonate 1.00 water Remainder

An aerosol was prepared using 92% by weight of the concentrate of Table VIII and 9% of the propellant, which was a mixture of dimethylether, isobutane and propane.

Example 7

Adhesive cosmetic patches could also be prepared according to the present invention. An adhesive hydrogel was prepared by mixing 30 g of 2-acrylamido-2-methylpropane sulfonic acid monomer in 1% aqueous solution of 20 g of distilled water and 5 g of methylene-bis-acrylamide. The solution was activated with 0.4% magnesium persulfate catalyst. Immediately after mixing the catalyst with the hydrogel solution, 0.1 g of ammonium malonate in 5 ml of water was added. The resulting solution was coated and solidified in a 50/50 mixture of propylene glycol and hydrophilic polyether. The deposited hydrogel formed was warmed at 40 ° C. for 24 hours in a hot air oven. The final water content of the hydrogel was 50%. The polystyrene backing was placed on the adhesive hydrogel.

Example 8

Disposable, single use personal small paper towel products have been described in accordance with the present invention. A 70/30 polyester / rayon nonwoven small paper towel was prepared with a weight of 1.8 g and dimensions of 15 cm × 20 cm. This small paper towel was infiltrated with the composition outlined in Table IX below.

ingredient weight% Ammonium malonate 7.50 glycerin 2.00 Hexylene glycol 2.00 Disodium Capryl Ampodiacetate 1.00 Gluconolactone 0.90 Silicone microemulsion 0.85 Witch Hazel 0.50 PEG-40 Hydrogenated Castor Oil 0.50 Spices 0.20 Vitamin E Acetate 0.001 water Remainder

The above description and examples illustrate selected embodiments of the invention. Modifications and variations thereof will be suggested to those skilled in the art, all within the spirit and scope of the invention.

Claims (6)

(i) about 0.0001% to about 30% by weight of a salt that is amine neutralized malonic acid; (ii) from about 1% to about 99.9% by weight cosmetically acceptable carrier, wherein the cosmetic composition has a pH in the range of about 1.8 to 6.5. The composition of claim 1 wherein said amine is ammonia. The composition of claim 1 or 2, wherein the malonic acid is present in each of the semi-neutralized and fully neutralized acids in a molar ratio in the range of about 1000: 1 to about 1: 1000. The composition of claim 3, wherein said molar ratio is from about 2: 1 to about 1: 200. The composition of claim 1, wherein the pH range is about 3 to about 5.5. (i) about 0.0001% to about 30% by weight of a salt that is amine neutralized malonic acid; (ii) fine lines, wrinkles, sagging skin, poor skin color, comprising providing a cosmetic composition comprising from about 1% to about 99.9% by weight cosmetically acceptable carrier and having a pH in the range from about 1.8 to 6.5 And a method of inhibiting signs of aging comprising those selected from the group consisting of blotch.