KR20040100010A - Health-supporting food being effective the prevention and solution of hangover - Google Patents

Abstract

PURPOSE: A health supplementary food containing dicalcium phosphate dehydrate, stearic acid, pyridoxine, thiamin and niacin as a main component is provided. It inhibits the conversion of alcohol to acetaldehyde and thus exhibits excellent detoxicating activity and reducing hangover symptoms. CONSTITUTION: The health supplementary food contains: a main ingredients including 40 to 58% by weight of dicalcium phosphate dehydrate, 20 to 38% by weight of stearic acid, 1 to 19% by weight of pyridoxine, 1 to 19% by weight of thiamin and 20 to 38% by weight of niacin; 1% by weight of optional ingredients containing cyanocobalamin, milk thistle, garlic, ginger, royal jelly and broccoli; and 10 to 20% by weight of excipients containing cellulose.

Description

Health-supporting food being effective the prevention and solution of hangover}

The present invention relates to a dietary supplement that is effective for preventing and eliminating hangovers, and more specifically, 40 to 58% by weight of dicalcium phosphate dehydrate, 20 to 38% by weight of stearic acid, pyridoxine (cyanocobalamin, milk thistle, garlic) with respect to the main material weight consisting of 1 to 19% by weight of pyridoxine, 1 to 19% by weight of thiamin and 20 to 38% by weight of niacin. Add a sub ingredient consisting of (garlic), ginger, royal jelly and broccoli to less than 1% by weight, and 10 to 20% by weight of cellulose as the excipient The present invention relates to a dietary supplement that is effective in preventing and resolving hangovers, which is added and coated with a food varnish.

Drinking alcohol enters the stomach and mixes with food, where about 20% of the gastric mucosa absorbs alcohol and some is broken down by alcohol dehydrogenase in mucosal cells. The remaining 80% is absorbed by the intestinal tract and enters the blood (the context), and the alcohol in the blood reaches the liver, most of which is metabolized by the liver to acetaldehyde and soon to acetic acid, finally carbon dioxide and water, and the rest by breath Excreted by urine The liver contains a large amount of alcohol dehydrogenase, which metabolizes about 80% of alcohol to the general population, and the remaining 20% is processed by a pathway called microsomal ethanol oxidation system (MEOS). If you drink alcohol and drink the next morning without alcohol, you should not have more than 2 or 3 cups of soju glass, that is, about 8 hours. However, if you drink a lot of alcohol, the situation changes, and the metabolic rate of alcohol gradually adapts and accelerates, so that the alcohol is not drunk well, which means that the activity of alcohol hydrogen hydrogenase is greatly promoted, and the amount of microsomal ethanol oxidation system is also increased. It means to exceed this limit. Microsomal ethanol oxidizing system acts on the metabolism of drugs other than alcohol, and drinking a lot of alcohol, cause anesthesia, antipyretic, analgesic, etc., the effect is not good. In addition, drinking alcohol and drugs at the same time delays the metabolism of the drug. Especially, when sleeping drugs, oral diabetes drugs, anticoagulants and alcohol are used, the metabolism of such drugs is suppressed. It is very dangerous because of the appearance. Alcohol metabolism produces toxic substances called acetaldehyde, which have a very bad effect on hangovers and cause hot flashes, headaches and vomiting. Acetaldehyde dehydrogenase (ALDH), which metabolizes acetaldehyde, has type 1 that does not work if acetaldehyde does not become high and type 2 that works at low concentrations. About 50% of Asians have type 2 genetic defects. If you drink the same amount of alcohol, people with type 2 deficiency suddenly increase the concentration of acetaldehyde, and even if you eat a small amount of alcohol, your face will soon be blown up and vomiting will occur. A person like this can cause death in the worst case if excessive drinking. Because alcohol plays a role in dilation of blood vessels, small amounts of alcohol are effective in the case of temporary narrowing of blood vessels, such as angina. In addition, alcohol promotes the destruction of nerve cells, and in particular, degeneration of the cell membranes changes the stimuli and information receptors present in the membranes, which impedes the development of the brain, which causes a decrease in intelligence, memory, computational power, and judgment. In the long term, it can cause dementia and gait disturbance. Especially, it is known to inhibit hormonal synthesis of organs with high cell division (sperm and ovary).

It is necessary to refrain from drinking, which causes the problems as described above, but most of them suffer from hangovers the next day due to excessive volume. Many products have been developed and sold to prevent and resolve hangovers, but have a satisfactory effect. Could not get

Accordingly, it is an object of the present invention to provide a dietary supplement that is effective in preventing and eliminating hangovers.

In order to achieve the above objects as well as other objects that are easily expressed in the present invention, 40 to 58% by weight of dicalcium phosphate dehydrate, 20 to 38% by weight of stearic acid, pyridoxine 1 to Cyanocobalamin, milk thistle, garlic, garlic, and ginger, based on the weight of the main material consisting of 19% by weight, 1 to 19% by weight of thiamin, and 20 to 38% by weight of niacin. (Subsidiary material consisting of ginger, royal jelly and broccoli) is added to less than 1% by weight, and cellulose is added as an excipient to 10 to 20% by weight based on the weight of the main ingredient, Detoxification of alcohol by rapid detoxification by manufacturing coated dietary supplement using energy, changing the energy, and when the ability to relieve hangover is reduced, that is, alcohol in case of excessive drinking By blocking the phase is changed to the acetaldehyde exhibits excellent detoxification during intake of alcohol could be obtained an excellent effect acts hangover.

The present invention is described in more detail as follows.

Health supplement foods effective for the prevention and resolution of hangover according to the present invention is 40 to 58% by weight of dicalcium phosphate dehydrate, 20 to 38% by weight stearic acid, 1 to 19% by weight pyridoxine % Cyanocobalamin, milk thistle, garlic, ginger, based on the weight of the main material, consisting of%, 1 to 19% by weight of thiamin and 20 to 38% by weight of niacin. ), Less than 1% by weight of royal jelly and broccoli, and 10-20% by weight of cellulose is added as an excipient, and food polish is used. By coating.

The method for preparing a dietary supplement that is effective in preventing and eliminating hangovers according to the present invention comprises a main ingredient consisting of dicalcium phosphate dihydrate, stearic acid, pyridoxine, thiamine and niacin and cyanocobalamin, milk thistle, garlic, ginger, royal jelly It is characterized by adding a submaterial consisting of broccoli, homogeneously mixing by adding cellulose as excipient, then morphing into tablet form, and then coating the surface of the tablet with a food varnish.

However, the main material, the subsidiary material and the excipient may be mixed and filled into a conventional soft capsule to prepare a capsule form, and the main material, the subsidiary material and the excipient may be mixed and completely dissolved by adding distilled water to prepare the liquid phase.

All ingredients used in the present invention have been approved by the US FDA and have no side effects that cause particular harm to the human body, but when used beyond the above range, they may not add synergistic effects and may cause unknown side effects.

Although the mechanism of action of the components used in the present invention on the prevention and elimination of hangovers is not clear, it is effective to prevent and eliminate hangovers, but the components studied by the inventors, etc. are mixed but repeated experiments It has been found to be most effective when mixed in the above categories.

However, since dicalcium phosphate dihydrate reacts with acetaldehyde and neutralizes, it is estimated that the dicalcium phosphate dihydrate has an effect on preventing and eliminating hangovers.

The dosage of the dietary supplement of the present invention prepared as a tablet is to take two tablets in the early stages of drinking, to take two tablets when drunk and to take two more in the morning, and to prevent hangovers. Before drinking two tablets before drinking and drinking two more pills to take again, but effective, but the constitution is different for each person, so you can take the appropriate amount to adjust to the constitution.

The health supplement of the present invention to eliminate the headache, vomiting, abdominal pain caused by heavy drinking, and before taking alcohol may vary depending on the constitution of the person, but will completely detoxify a large amount of alcohol in 3 to 4 hours In addition, people who drink too much often, because of fast alcohol detoxification (decomposition) to protect the liver and the strong effect of converting alcohol into energy can maintain a large health, because alcohol is converted into energy In the morning, the mood can be refreshed, as well as to enhance performance. Even if taken for a long time or ingested several times, there is no poisoning or side effects and residual components are discharged to the body through urine or sweat.

The following examples illustrate the invention in more detail, but do not limit the scope of the invention.

Example 1

Prepare the main ingredients of 108 mg of dicalcium phosphate dihydrate, 50 mg of stearic acid, 5 mg of pyridoxine, 4 mg of thiamin, and 50 mg of niacin per tablet. Subsidiary materials are weighed and added to the main ingredient, 25 mg of cellulose (trade name: Solka floc) is added as an excipient, homogeneously mixed, and then pulverized into tablets, followed by food polish (trade name: Food Glaze Number 4 White) glaze # 4white)) was used to dipping the surface of the tablet (dipping coating) and dried at room temperature to prepare a dietary supplement that is effective in preventing and eliminating hangover of the present invention in tablet form.

Experimental Example 1

The clinical supplements prepared in Example 1 were conducted in four cities for Americans and Japanese Koreans.

It was conducted between January 1998 and December 2000 for Americans in San Francisco and Los Angeles, and between May 2002 and January 2003 for Japanese and Koreans in Tokyo, Japan, and Seoul, Korea, respectively. Was done.

The subjects who participated in the clinical trial were randomly selected in each city, each participant had experience of alcohol consumption and knew the alcohol intake and form that led to the hangover the next day after drinking. In the clinical trial, drinking was carried out from 8 pm to 12 pm, and at the same time as the start of drinking, two tablets of the tablet-type dietary supplement of the present invention were taken and two more tablets were taken after drinking.

After taking 2 tablets, all subjects described the amount of alcohol their body could tolerate for 4 hours, and the amount of alcohol consumed by each subject was accurately measured during the experiment, and 2 more tablets after drinking After that, the next day, the degree of hangover was checked and the effects of hangover prevention and resolution and the intention to recommend to others were surveyed in five stages and the results are listed in Table 1.

1. Very bad: not strongly recommended

2. Poor: Not recommended.

3. Normal: Recommended

4. Good: fairly recommended

5. Very good: highly recommended

Experimental group Participants Recommended score satisfaction Survey Score Tokyo 14 4.71 94.2% 3.90 Seoul 52 4.96 99.2% 4.23 Los angeles 14 4.71 94.2% 3.61 San Francisco 18 4.61 92.2% 4.91

As described above, in the present invention, 40 to 58% by weight of dicalcium phosphate, 20 to 38% by weight of stearic acid, 1 to 19% by weight of pyridoxine, and 1 to 19 of thiamin. Cyanocobalamin, milk thistle, garlic, ginger, royal jelly, relative to the main material weight consisting of 20% to 38% by weight of niacin; By adding less than 1% by weight of the broccoli (subsidiary material), by adding 10 to 20% by weight of cellulose to the main material weight as an excipient, and manufacturing a dietary supplement coated with a food varnish Detoxification breaks down alcohol at a rapid rate, but turns it into energy and reduces the ability to resolve hangovers. It represents a good detoxifying the city was able to get a good hangover effect the action.

Claims (1)

40-58 wt% of dicalcium phosphate dicalcium phosphate, 20-38 wt% of stearic acid, 1-19 wt% of pyridoxine, 1-19 wt% of thiamin, and niacin Consists of cyanocobalamin, milk thistle, garlic, ginger, royal jelly and broccoli Subsidiary materials are added in less than 1% by weight, cellulose is added as an excipient to 10 to 20% by weight based on the weight of the main material, and is coated with a food varnish, effective for the prevention and remedy of hangovers food.