KR20040062456A - Analysis of protein structure stability by a thermodynamic energy function containing Ramachandran angle and interaction between two amino acids - Google Patents

Abstract

PURPOSE: An analytical method of protein structure stability by thermodynamic energy function containing Ramachandran angle and interaction between two amino acids is provided, thereby easily determining whether the protein structure to be analyzed is natural structure. CONSTITUTION: The analytical method of protein structure stability by thermodynamic energy function containing Ramachandran angle and interaction between two amino acids comprises judging whether the new protein/protein group satisfies the mathematical equation 9 using the score parameters, wherein the score parameters are calculated by the mathematical equation 9 using the groups, wherein the groups comprise a plurality of training protein group showing the natural structure extracted from the protein data of which amino acid sequence and tertiary structure via X-ray determination are known; a training decoy structure protein group which is formed by corresponding the amino acid sequence of protein A having length of NA to from a first amino acid to NA amino acid of protein B having the same or longer length of NB than NA, and repeating the correspondence with increasing one amino acid position of protein B; score parameters calculated by the mathematical equation 9 using score function showing energy level when a sequence s has a structure of letter "L" and containing all kinds of amino acids and local environment; new protein/protein group which does not belong to the training protein group; and new decoy structure protein group which is formed by the same method of the training protein group using the training protein group.

Description

Analysis of protein structure stability by a thermodynamic energy function containing Ramachandran angle and interaction between two amino acids}

The present invention relates to a method for analyzing protein structure stability, and more particularly, to consider the pairwise contact between amino acids considering the Ramachandran angle, which affects the binding angle of each amino acid due to the influence of residues, as an environmental variable. Ramachand is a method for analyzing the structural stability of proteins by thermodynamic energy functions including the bonds between angles and amino acids.

In general, understanding the exact structure of proteins has many useful benefits, including the diagnosis of the causes of genetic diseases and the development of new reagents. Because of this usefulness, many research efforts have been made to recognize the natural structure of proteins, and many researches are developing various new methods.

The most common method for determining protein structure is by X-ray crystallography and nuclear magnetic resonance spectroscopy (NMR SPECTROSCOPY method, hereinafter referred to as NMR). However, these methods have a disadvantage in that a lot of effort and time are required by grasping the structure by field experiments.

Recently, various methods for determining the structure of proteins have been proposed without direct experiments. The sequence and the structure of each amino acid constituting the protein are grasped to obtain information indicating the structure of the protein.

That is, important information indicating the structural characteristics of a protein is already described in the amino acid sequence of the protein, and it is well known that the amino acid sequence determines the natural structure of the protein.

The main problems in folding to understand protein structure include predicting protein structure, designing amino acid sequences, and understanding the procedures of the protein folding process. In order to solve the protein folding problem, an appropriate protein score (energy) function that includes the thermodynamic and kinetic properties of the protein is essential.

Interactions between atoms in a protein are very complex, so depending on the atomic level potential may be impractical.

Coarse-grained descriptions incorporating the fine properties of proteins usually provide a simple and efficient way to study protein folding problems, with each amino acid being coarse grained like isotropic beads connected along the backbone. In view, all interactions within a protein are effectively described by the interaction between amino acids.

Typically, the amino acid sequence contains information necessary for protein structure and protein folding, and the natural structure of the protein is known to correspond to the structure having the lowest free energy compared to other competitive structures.

Several approaches to determining protein coarse grain score functions that depend on the sequence and characteristics of amino acids are known. The conditions of a good protein score function are that all other competing structures must be present when the amino acid sequence score is placed in the natural structure. This function must stabilize the natural structure of as many proteins as possible at the same time so that it has a lower value than the score when

A conventional approach to determining this function is the quasi-chemical method determined by Miyazawa and Jernigan. This approach is essentially counting the frequency of pairwise contacts between the 20 different amino acids that make up a protein. Although the Miyazawa-Jernigan contact matrix (hereinafter referred to as the MJ matrix, 20x20) does not stabilize the natural structure of all the proteins involved by using quasichemical methods, it has had a tremendous impact on understanding the key features of proteins.

Bowie et al. Developed protein monoscore scores by combining the local environment of amino acids. This function was used to determine the affinity that a given amino acid sequence would lie in a given protein structure. This function stimulated many structural recognition methods to achieve better natural structure recognition, but it did not stabilize all of the natural structural proteins considered.

In other words, the first thing to understand in order to understand protein folding is the interaction of the amino acids that are the basic units of the protein. From this point of view, Bowie et al. Transformed the three-dimensional structure of a protein into one-dimensional information, indicating an environmental score that indicates how much the protein sequence prefers this structure when the protein sequence lies in a specific three-dimensional structure. ) Was calculated. Introduced to calculate this environmental score is the amino acid environmental variables.

An environment finalization variable represents two cases:

First, when the amino acid sequence of a protein is determined, it can be represented by three types of secondary structures (α-helix, β-strand and loop structure) due to the interaction between each amino acid. Appears in three ways.

Second, it is classified according to affinity with water. In fact, since most proteins have a form dissolved in a solvent in vivo, the degree of hydrophobicity is different depending on the structure of each amino acid, and this is considered. Generally, three types of hydrophobic environmental parameters are represented. The three divisions are as follows. The rate at which amino acids are exposed to the solvent is calculated using the Richard's algorithm as the ratio of the solvent contact area of amino acid X to the unfolded state of the amino acid in the form of Gly-X-Gly. Depending on the degree of hydrophobicity (or solvation), the values of the percentages exposed to the solvent are divided by less than 10%, 10-50%, and more than 50%, respectively, buried (Buried, denoted B below). , In the middle (MEDIUM, hereinafter referred to as M), and if exposed (EXPOSED, hereinafter referred to as E).

As mentioned above, the state of each protein can be represented by a total of nine environmental composition variables by combining three secondary structure environment variables and three hydrophobic environment composition variables. It is used as a measure of the natural structure of a protein.

However, using nine known environmental variables and using a statistical method does not sufficiently indicate the environment in which each protein is located, and thus there is a problem that the recognition rate of natural structures is not high.

Accordingly, the present invention has been made to solve the above-mentioned problems of the prior art, and uses a protein score (energy) function including the mating contact between lamachandran angle and / or amino acids to stabilize the natural structure of the proteins. The aim of the present invention is to provide a method for analyzing the structural stability of proteins by thermodynamic energy functions including the binding between angles and amino acids, which can analyze the structural stability of a given protein by neural network learning theory and protein threading method.

1-A diagram showing the Ramachandran angle used in the present invention.

Figure 2 shows the distribution of amino acids of the protein on the ramachandran plot.

The present invention for achieving the above object, a plurality of training protein group showing a natural structure extracted from the protein data known amino acid sequence structure and tertiary structure by X-ray crystallography; In the training protein group, A protein of length N _A and _B protein of length N _B (N _A ≤N _B ), the sequence of protein _A starting from the first amino acid of protein B without a gap and ending N _A times To produce one decoy structure of protein A, and to match the sequence of protein _A to the structure starting from the second amino acid of protein B and ending N _A + 1th, the other decoy structure of protein A. And repeat the method of generating another decoy structure of protein A by matching the sequence of protein _A to the structure starting from the third amino acid of protein B and ending with N _A + 2nd. A training decoy structural protein group formed by forming a decoy structure of the protein for each of the naturally occurring proteins involved; Using a score function that quantitatively represents the degree of energy when the sequence s is in the structure Γ, including all kinds of amino acids and local environments, Score parameters; A new protein / new protein group not belonging to the training protein group; In the same method obtained from the training decoy structural protein group using the training protein group, a new decoy structural protein group formed on the training protein group that is equal to or longer than the length of the new protein / new protein group; Thermodynamics, including the association between the amino acid and the lamachandran, which determine whether the structure of the new protein is a natural structure by determining whether the new protein / new protein group meets the following equation using the score parameter: The method of analyzing the structural stability of proteins by energy function is a technical point.

Wherein n (i, m) and n (i, m) ^D are the number of amino acids in the m local environment where i-type amino acids in the natural structure and the decoy structure, respectively, are in 9 environments and the Φ-Ψ matrix, ε (i, m) is the score parameter associated with this amino acid, and n (i, j; k, l) and n (i, j; k, l) ^D are pairwise contacts in the natural and decoy structures, respectively. Is the number of amino acids in the local environment with k, l amino acids of the form i, j linked together, ε (i, j; k, l) is the score parameter associated with these amino acids, and p is the ramachandran Number of rows / columns when representing angle (Φ, Ψ) as square matrix.

In addition, the present invention includes a plurality of training protein groups representing a natural structure extracted from protein data of which amino acid sequence structure and tertiary structure by X-ray crystallography are known; In the training protein group, A protein of length N _A and _B protein of length N _B (N _A ≤N _B ), the sequence of protein _A starting from the first amino acid of protein B without a gap and ending N _A times To produce one decoy structure of protein A, and to match the sequence of protein _A to the structure starting from the second amino acid of protein B and ending N _A + 1th, the other decoy structure of protein A. And repeat the method of generating another decoy structure of protein A by matching the sequence of protein _A to the structure starting from the third amino acid of protein B and ending with N _A + 2nd. A training decoy structural protein group formed by forming a decoy structure of the protein for each of the naturally occurring proteins involved; Using a score function that quantitatively represents the degree of energy when the sequence s is in the structure Γ, including all kinds of amino acids and local environments, Score parameters; A new protein / new protein group not belonging to the training protein group; In the same method obtained from the training decoy structural protein group using the training protein group, a new decoy structural protein group formed on the training protein group equal to or longer than the length of the new protein / new protein group; Thermodynamics, including the association between the amino acid and the lamachandran, which determine whether the structure of the new protein is a natural structure by determining whether the new protein / new protein group meets the following equation using the score parameter: Methods of analyzing the structural stability of proteins by energy function are also technical points.

Wherein n (i, m) and n (i, m) ^D are the number of amino acids in the m local environment where i-type amino acids in the natural structure and the decoy structure, respectively, are in 9 environments and the Φ-Ψ matrix, ε (i, m) is the score parameter associated with this amino acid, and p is the number of rows / columns when representing the lamachandran angle (Φ, Ψ) in a square matrix.

Here, the training protein group is a protein having a homology of less than 30%, the new protein / new protein group is a protein having a homology of less than 90%, the training protein group is a protein taken from PDB select and WhatIF (1) a structure obtained by X-ray crystallography, (2) a protein without a non-standard amino acid, (3) a protein without a broken chain, and (4) a mutated structure It is desirable to have no protein.

And, the above equation is satisfied for all the training decoy structure belonging to the training decoy structure protein group, the score parameter is a value to satisfy all of the equation for the training decoy structure, the score parameter is a neural network It is desirable that the calculation be repeated by repeating the learning and protein threading tests.

In addition, the solution that satisfies the above equation must be: (1) the score of the natural structure of a given protein must be lower than the average score of a random sequence with a constant composition of amino acids on its own natural structure, and (2) The score of the natural structure of a protein is obtained by calculating a score inequality that satisfies the condition that it must always have a lower value than the average score of its own sequence in the decoy structure, and after obtaining a score parameter that satisfies the score inequality , A threading test is performed to verify whether the above equation is satisfied for all decoy structures belonging to the training decoy structure protein group using the score parameter, and a correction value is added to the score parameter for the decoy structure that does not satisfy the equation. In addition, update the updated score parameter as an independent variable By forming the first failing decoy structure inequality, a score parameter satisfying the inequality coincided with the score inequality is calculated, and the above equation is applied to all decoy structures belonging to the training decoy structure protein group using the score parameter. A threading test is performed to verify whether or not it satisfies, and the decoy structure that does not satisfy the above equation is updated by adding a correction value to the score parameter, and forming a second failing decoy structure inequality using the updated score parameter as an independent variable. By repeating a series of processes for calculating the score parameter that satisfies the matched inequality by matching the score inequality and the first failure inequality, the score parameter that satisfies the equation for all the decoy structures belonging to the training decoy structure is calculated. desirable.

On the other hand, the local environment includes three secondary structures α-helix, β-strand and loop structure for one amino acid, and 10% of the values of the ratio exposed to the solvent depending on the degree of hydrophobicity (or solvation). These values are subdivided into values of less than, 10 to 50%, and more than 50%, and each of these values is classified into three classes: buried, medium, and exposed; and Ramachandran angles (Φ, Ψ) are each 40 °. Each of them is divided into 9 equal parts on the x and y axes, and a total of 81 local constituents, the local environment, are formed.In the case of considering only the rama one body, 14,580 score parameters are obtained and the rama one body and two body are calculated. At the same time, it is desirable to obtain 30,870 score parameters.

Therefore, it is useful for structural stability analysis of proteins to determine whether the structure of a given protein is natural structure by introducing neural network learning theory and protein threading method while introducing environmental score function considering environmental variables including Ramachandran angle. There is an advantage.

Hereinafter, embodiments of the present invention will be described in detail.

In the present invention, it will be introduced to the local environment which is a new environmental covariation variable, the Ramachandran angle as a single amino acid and / or pairwise contact between amino acids and amino acids. First, the Ramachandran angle will be described briefly.

As shown in Figure 1, each amino acid is connected by a peptide bond, the CO-NH bond is a peptide plane structure that does not rotate, forming a single plane, the coupling site is a peptide bond. Therefore, in the bonding structure, since the central carbon Cα-C 'binding site and the Cα-N binding site are deanyl bonds, the bond can be rotated about the axis. Therefore, φ angle of Cα-N and ψ angle of Cα-C 'are defined as angles of lamachandang as backside angles between the peptide planes and the side chains of amino acids in the main chain of the polypeptide, which is the binding of amino acids. The Ramachandran angles φ and ψ are plotted on the x and y axes, respectively. φ and ψ are not all angles allowed. That is, the allowed angle is limited because of the steric hindrance of the main and side chains. The angles of φ and ψ given in the protein structure can be easily calculated geometrically, and a picture of the lamachandran angles φ and ψ on the x and y axes, respectively, is called a ramachandran plot.

The Ramachandran angle (φ _i , ψ _i ) of the i-th amino acid in the protein in the Ramachandran plot corresponds to one point, which is dependent on the secondary structure in which the amino acids lie in the protein or the type of the side chain Therefore, it is limited to a limited area. For example, in the case of proline, the side chain is shaped like a ring so that the backside is confined to a very small area on the Ramachandran plot. On the other hand, glycine (glycine) has only one hydrogen atom in the side chain, so it can be distributed somewhat uniformly in almost all regions without being limited by the side chain. In addition, since this dihedral angle is limited to a certain region on the Ramachandran plot depending on the secondary structure in which the amino acid is located in the protein, the local environment is an important new environmental parameter that describes the structural characteristics of amino acids in the protein. This can be

Thus, the Ramachandran plot can be used as a new measure to explain the environment of each amino acid by dividing it into the φ and ψ axes. For example, the number of environmental coherence variables may vary depending on the number of equal parts, but in the present invention, for convenience of description, the angles are divided by 40 ° by 9 equal parts on the x and y axes, respectively, for a total of 81 Ramachandral environments. We created a local environment that was a variable. For example, as shown in FIG. 2, a hydrolase protein (1EUL) consisting of 994 amino acids is shown on a Ramachandran plot. In Figure 2 (a) is a picture showing the angle of Ramachandran (φ _i , ψ _i ) that all amino acids, it can be seen that the ramachand is unevenly distributed in each space. This is because of the interaction between the side chain of the amino acid and the backbone chain of the protein to which the amino acid belongs due to the spatial constraints of the side chain existing in the amino acid. Figures (b) and (c) show the Ramachandran plots of amino acids in the α-helix and β-stranded structures, which are the secondary structures of proteins, respectively. From these results, it can be seen that the lamachandran angle (φ, ψ) is strongly constrained in space depending on which secondary structure of the amino acid is in the protein. The amino acid constraints in the Ramachandran plot show that the amino acid sequence of the protein has a very good condition as a local environment, which is the binding variable of the protein environmental score function required to determine the natural structure of the protein. have. Therefore, in the present invention, it is possible to improve the method of recognizing the natural structure of proteins by introducing Ramachandran angle as a new environmental parameter in addition to the existing environmental parameter.

Hereinafter, a method of recognizing a natural structure of a protein by interpreting an environmental score function by introducing a lamandran angle according to the present invention as an environmental covariation variable will be described in detail.

1. Build a representative protein database that represents natural structure

First, in order to extract the environmental score function, a protein database representing the structure of proteins existing in nature is required. For this purpose, the following protein database was constructed.

In the present invention, as a representative protein database whose natural structure is known (hereinafter, referred to as a training protein), a protein is selected from the following conditions.

The basic selection of the training protein group was taken from PDB select (hereinafter referred to as PDB) and WhatIf. PDB select (http://www.cmbi.kun.nl/gv/pdbsel) and WhatIf (http: // Choose 3,032 representative proteins from www.cmbi.kun.nl/swift/whatif, representing all other classes of the Structural Classification of Protein (SCOP) classification with less than 30% homology It was. Here the PDB file and WhatIF consist of proteins selected from all known structures using the "all-against-all Smith / Waterman alignment" method between protein chains.

In the present invention, the proteins satisfying the following conditions among the protein group obtained from the PDB file and WhatIF were selected as training proteins.

(1) X-ray crystallography

(2) the structure does not contain non-standard amino acids

(3) structure without broken chains

(4) protein without mutated structure

The number of proteins contained in the training protein group selected by the above conditions was 1006, which is shown in Table 1 below.

Non-overlapping proteins of the 1,006 training protein group have 53 to 994 amino acids in length.

<Table 1>

1,006 natural rescue training proteins

16PK, 1A1I, 1A1X, 1A34, 1A3K, 1A44, 1A65, 1A6M, 1A8E, 1A8H, 1A8L, 1A8P, 1AC5, 1AF7, 1AGI, 1AH7, 1AIL, 1AK0, 1AKO, 1AL3, 1AMF, 1AMK, 1AMK, 1AMK, 1AMK 1AMY, 1AQB, 1ARU, 1ATG, 1AUQ, 1AXN, 1AZ9, 1AZQ, 1B0U, 1B0X, 1B1C, 1B56, 1B8O, 1BB9, 1BD8, 1BDO, 1BEA, 1BFD, 1BG2, 1BEA, 1BGV, 1BHEK1, 1BHEK1 1BKR, 1BM8, 1BN7, 1BN8, 1BQC, 1BQK, 1BR9, 1BTN, 1BU2, 1BUO, 1BWZ, 1BX4, 1BXA, 1BXO, 1BYB, 1BYI, 1BYQ, 1BYR, 1C0P, 1C1K, 1C52, 1C2C, 3C2A44 1C75, 1C8Z, 1CB8, 1CBY, 1CC8, 1CCZ, 1CEX, 1CFB, 1CGT, 1CHD, 1CIP, 1CJW, 1CKA, 1CLC, 1CNV, 1COJ, 1CPQ, 1CSH, 1CSN, 1CTJ, 1CTQ, 1CUO, 1CVC 1CYW, 1CZT, 1D2N, 1D4O, 1D7O, 1D7U, 1DBG, 1DFX, 1DHN, 1DK8, 1DLY, 1DOI, 1DOZ, 1DPE, 1DS1, 1DXJ, 1DXY, 1E1A, 1E20, 1E43, 1E58, 1E58, 1E58, 1E55 1EB6, 1ECD, 1ECR, 1ED1, 1EDG, 1EEM, 1EG3, 1EI5, 1EJ0, 1EJ8, 1EJJ, 1EKG, 1EL4, 1ELR, 1EOK, 1EP0, 1EQF, 1EU8, 1EUG, 1EUL, 1EUR, 1EW0, 1EW2, 1E4 1EYH, 1EZJ, 1EZW, 1F20, 1F3L, 1FC9, 1FCY, 1FHG, 1FI2, 1FKJ, 1FL2, 1FS7, 1FSZ, 1FX2, 1FXL, 1FXS, 1G1T, 1G2R, 1G5A, 1G5T, 1G66, 1G6S, 1G7F, 1G8F, 1G9O, 1GA0, 1GA6, 1GAL, 1GC6, 1GCA, 1GCB, 1GND, 1GNU, 1GNY, 1GOF, 1GP0, 1GP6, 1GSA, 1GQV 1GUI, 1GVP, 1GXQ, 1GXU, 1GYU, 1GZC, 1H61, 1H6H, 1H6L, 1H6T, 1H75, 1HB6, 1HCZ, 1HD2, 1HDO, 1HF8, 1HH5, 1HH8, 1HKA, 1HNJ, 1HHV, 1HHVV 1I2T, 1I6P, 1I76, 1I8A, 1I9G, 1ID0, 1IDO, 1IFC, 1IHG, 1IM5, 1IQQ, 1IQZ, 1IS3, 1ITX, 1IUA, 1IXH, 1J8Q, 1J8U, 1JA9, 1JAK, 1JB3, 1JC3, 1JC3 1JG1, 1JHD, 1JJF, 1JJY, 1JK7, 1JLN, 1JM1, 1JO8, 1JU3, 1JUK, 1JV4, 1JYH, 1K12, 1K1B, 1K4I, 1K5C, 1K6A, 1K6W, 1KDK, 1KNG, 1KNG, 1KNG, 1KIT, 1KOK, 1KP6, 1KPF, 1KQ3, 1KQR, 1KR7, 1KTE, 1KUG, 1KWG, 1KWH, 1KY2, 1L2R, 1L6P, 1LAM, 1LBU, 1LC5, 1LCL, 1LIT, 1LJ5, 1LKI, 1LO7, 1LPL, 1LPU 1LY2, 1M7B, 1M8Z, 1MAI, 1MGT, 1MLA, 1MML, 1MNZ, 1MOQ, 1MRJ, 1MSK, 1MUG, 1MUY, 1MWP, 1NAR, 1NFP, 1NIF, 1NKR, 1NLS, 1NOX, 1NPK, 1NPS, 1NSJ, 1OAA 1PA2, 1PBE, 1PBV, 1PDO, 1PGP, 1PII, 1PJC, 1PLC, 1PMI, 1POA, 1POC, 1POT, 1PRN, 1PSZ, 1PTF, 1PUC, 1QAU , 1QAZ, 1QB0, 1QB7, 1QCX, 1QF5, 1QGI, 1QGX, 1QHQ, 1QHV, 1QI7, 1QJ4, 1QJ8, 1QJD, 1QK8, 1QKJ, 1QNF, 1QNR, 1QNX, 1QQ9, 1QQ, 1QQ, Q , 1QUU, 1R69, 1RA9, 1RCB, 1RCY, 1RFS, 1RIE, 1RIS, 1RL6, 1RMD, 1RMG, 1ROP, 1SBP, 1SFP, 1SKF, 1SML, 1SNC, 1SRA, 1SRV, 1SUR, 1SVB, 1T1D, 1TCA, 1TFE, 1TFE , 1TIG, 1TL2, 1TML, 1TMY, 1TUL, 1U9A, 1UBI, 1UKZ, 1UOK, 1URO, 1UTE, 1VCC, 1VHH, 1VID, 1VIE, 1VLS, 1VNS, 1VSR, 1WAB, 1WBA, 1WDN, 1WHI, 1WHO, 1XNB , 1YGE, 1ZIN, 1A17, 1A26, 1A32, 1A76, 1AD6, 1AEP, 1AEW, 1AI3, 1AIR, 1AJ2, 1ALY, 1AN8, 1AOL, 1ASH, 1ASS, 1AUA, 1B71, 1B74, 1B9H, 1B9Z, 1BAJF1BEO , 1BIX, 1BLE, 1BPI, 1BPY, 1BQS, 1BV1, 1BVB, 1BVO, 1BYL, 1C0A, 1C4X, 1C76, 1C7Q, 1CEM, 1CFR, 1CIY, 1CJC, 1CJS, 1CL8, 1CQQ, 1CS6, 1CX, 1CCC , 1CZJ, 1D0V, 1D2K, 1D7Y, 1D9Y, 1DAB, 1DCQ, 1DD5, 1DDV, 1DEO, 1DG9, 1DHR, 1DIV, 1DLI, 1DLL, 1DMR, 1DMT, 1DMU, 1DQ3, 1DQO, 1DRW, 1DZ3 , 1DZF, 1E6U, 1E7F, 1E87, 1EAF, 1ECY, 1EDQ, 1EDT, 1EI9, 1EJE, 1EQ6, 1ESC, 1EVH, 1EW3, 1F7S, 1FAO, 1F AS, 1FCE, 1FL0, 1FLP, 1FNF, 1FP5, 1FRB, 1FY7, 1FZQ, 1GAK, 1GEJ, 1GEN, 1GLN, 1GPC, 1GYM, 1HFX, 1INP, 1IOV, 1JET, 1JMC, 1JSE, 1KLO, 1KUH, 1LRV 1MJC, 1MZM, 1NG1, 1NP4, 1OBR, 1OPC, 1OSA, 1OTH, 1OXA, 1PEA, 1PFO, 1PHF, 1PHK, 1PKP, 1PLQ, 1PUD, 1QAM, 1QF9, 1QGO, 1QHO, 1QKK, 1QLP, 1QQS, 1QQS 1QU2, 1QVA, 1RKD, 1SEK, 1SFE, 1SQC, 1TGO, 1UAE, 1UXY, 1XSM, 1YTW, 1ZXQ, 1A6F, 1B0M, 1B87, 1BFG, 1BZ4, 1DVO, 1DZO, 1EB4, 1LV, 1ERV, 1IAM 1MKP, 1MOF, 1QQ4, 1RGS, 119L, 1AD2, 1AQT, 1BIF, 1C3D, 1CDY, 1FMB, 1JDC, 1KXU, 1MDL, 1QLM, 1QOY, 1QQH, 1SKZ, 1UBY, 1VIN, 1WWC, 1A73, 1A73, 8A 1ALV, 1AOJ, 1AQ0, 1AUO, 1AYF, 1B2P, 1B3A, 1B5E, 1B66, 1B8A, 1BEB, 1BKP, 1BKZ, 1BM9, 1BXY, 1BYF, 1CNZ, 1COL, 1COZ, 1D0Q, 1D3D, 1D3D, 1D3VH 1DXE, 1DYS, 1E15, 1E42, 1E9G, 1ECS, 1EJF, 1ERZ, 1EW6, 1EZG, 1F05, 1F0K, 1F39, 1F5V, 1F74, 1F9M, 1FB3, 1FLM, 1FN9, 1FVK, 1GLQQ8G 1GTV, 1GXY, 1GYG, 1H8P, 1H97, 1H9M, 1HM9, 1HW1, 1IAZ, 1IOO, 1ISU, 1ITU, 1IU8, 1J9L, 1JFL, 1JFR, 1JH6, 1 JI1, 1JQE, 1JR2, 1JR8, 1JTK, 1K20, 1K94, 1KEP, 1KPT, 1KQP, 1KZQ, 1LQP, 1M55, 1M8A, 1MHD, 1MKA, 1MOL, 1MR8, 1NBC, 1NSC, 1PSR, 1QQ, 1HQ, 1QQ5, 1SEI, 1TOA, 1VCA, 1YAC, 1AOE, 1B00, 1B3T, 1B78, 1BK5, 1BRW, 1BYK, 1C2T, 1CLE, 1D1G, 1DDG, 1DQE, 1EE2, 1EEJ, 1EI7, 1EN7, 1ETP, 1FP, 1EY 1G1K, 1G71, 1GDH, 1GNW, 1HST, 1HUL, 1IMB, 1PFK, 1QFE, 1QFH, 1QJV, 1QR4, 1QSD, 1QVB, 1TKI, 1VSG, 1XVA, 1YPR, 19HC, 1A0A, 1A28, 1A7V, 1A7V, AA 1AOC, 1AOH, 1ASY, 1ATL, 1AYO, 1B16, 1B4K, 1B67, 1B6B, 1B6T, 1BBH, 1BE9, 1BF6, 1BFT, 1BHT, 1BSM, 1BTM, 1C02, 1CF7, 1CI9, 1CP2, 1CQD, 1CF, 1CZ 1D9C, 1DJ0, 1DKZ, 1DL5, 1DP4, 1DQZ, 1DSZ, 1DU5, 1DXM, 1DYN, 1E19, 1ECM, 1EG9, 1EK6, 1EMV, 1ESG, 1EUJ, 1EUV, 1EXC, 1EXT, 1EYV, 1F3F46, 1F41 1FP3, 1FQT, 1G1B, 1G38, 1G9Z, 1GK9, 1GQI, 1GVE, 1GXM, 1H6F, 1H7E, 1HM5, 1I0D, 1I4F, 1I4U, 1I6W, 1ICR, 1IHR, 1IRD, 1JAT, 1JAY, JJJ, JJJJ 1JU2, 1K9J, 1KSA, 1KTG, 1KU0, 1KV8, 1L6X, 1L9F, 1LB6, 1LBE, 1LBW, 1LH0, 1LXT, 1M4I, 1MPG, 1PBW, 1QG7, 1QKS, 1QLW, 1QNA, 1QQJ, 1QTN, 1QU7, 1SFT, 1TF4, 1TX4, 1XIK, 1A0F, 1A6J, 1AVP, 1B34, 1B3U, 1B94, 1BHG, 1BJA, 1BMQ, 1BMT, 1BO4, 1BWK8B 1CHR, 1CKM, 1CL2, 1CQ3, 1D2F, 1D2O, 1DAP, 1DEL, 1DM9, 1EBF, 1EC6, 1ECE, 1EFV, 1EGA, 1EM9, 1EXB, 1F0Y, 1F37, 1F4T, 1F5M, 1F5WF 1G8F, 1F8PU 1FUR, 1G51, 1G6N, 1HDM, 1HEI, 1HKB, 1IVY, 1JOT, 1NOY, 1NSE, 1ORD, 1OTC, 1OUN, 1PDK, 1PYS, 1QB2, 1QC7, 1QCI, 1QEX, 1QG3, 1QMH, 1QPB, 1R2F 1TKA, 1VFR, 1VHR, 1VMO, 1YAG, 1A2P, 1C5E, 1EL6, 1HTW, 1JLJ, 1LUA, 1OBW, 1TGX, 1AHS, 1B77, 1BS4, 1EZ3, 1A12, 1B5Q, 1B93, 1CZY, 1DBF, 1DCI 1EUA, 1F83, 1FC3, 1FTF, 1G3K, 1GMY, 1HX6, 1K4M, 1NZY, 1OTG, 1TAD, 1YAI, 1AVQ, 1BPO, 1D8D, 1DBT, 1E2A, 1E6T, 1FTM, 1NMT, 1P35, 1RPX, 1TUP, 6TUP 1DVR, 1ELU, 1IIB, 1LXD, 1SVP, 1AN4, 1BDY, 1ELK, 1I0R, 1B9X, 1CN4, 1CUN, 12AS, 1CM5, 1KNY, 1QJW, 1QQ2, 1AOX, 1DPG, 1LAT, 1POX, 1AVY, 1AZS, 1AZS 1URN, 1C1Y, 1AIS, 1AWC, 1DS6, 1HLO, 1KAC, 1BH9, 1B7Y, 1ITB, 1QRV, 1HSB, 1CG8, 1E7K, 1JQL, 1HNN, 1I1R , 1JCQ, 1CK4, 1GL4, 1IG3, 1GD0

Given the training protein group, the present invention generates decoy structures for each protein belonging to the training protein group through a gapless threading method using the training protein group to form a training decoy structure protein group. The number of trained decoy structural protein groups is about 7,8.2 million (exactly 78,155,894).

Referring to the process of forming the decoy structure as an example.

In the training protein group, A protein of length N _A and _B protein of length N _B (N _A ≤N _B ), the sequence of protein _A starting from the first amino acid of protein B without a gap and ending N _A times To produce one decoy structure of protein A, and to match the sequence of protein _A to the structure starting from the second amino acid of protein B and ending N _A + 1th, the other decoy structure of protein A. To generate another decoy structure of protein A by matching the sequence of protein _A with the structure starting from the third amino acid of protein B and ending with N _A + 2nd, and repeating the above method _A decoy structure of N _B -N _A +1 can be formed for the protein.

In the same manner, the decoy structure is formed by repeating the above process for other proteins, and the decoy structure obtained for the protein belonging to the training protein group by repeating the above process is about 7,820 as described above. One hundred thousand (or exactly 78,155,894) could be produced.

In the present invention, we constructed a protein score function that stabilizes all 1,006 natural structures with homology less than 30% by neural network learning and protein threading. It is to define a function and analyze the structural stability of a given protein from it.

The score function according to the present invention is defined according to the local environment classification in which the amino acid is placed, and the case of considering the local environment related to one amino acid considering the lamachandran angle will be dealt with in the first embodiment. Considering one amino acid including and two amino acids in pairwise contact at the same time will be dealt with in the second embodiment.

First Embodiment

The first embodiment of the present invention relates to one amino acid that is a one-body, and it is necessary to classify the local environment of amino acids to define a monolithic score function.

Considering the Ramachandran angle, as described above, the backside angles Φ and Ψ are divided into 40 equal parts on the Ramachandran plot and divided into 9 equal parts on the x and y axes, respectively. It has a local environment. By the way, in the present invention, it is divided into nine equals for convenience and may be divided into different and belong to the scope of the present invention.

The local environment of amino acids is classified into nine categories of protein structure.

Each amino acid can be found in one of three secondary structures (α-helix, β-strand and loop structure).

In addition, the ratio of the amino acid exposed to the solvent is calculated using the Richard algorithm as the ratio of the solvent contact area of the amino acid when the amino acid X is present and the amino acid in the unfolded state such as Gly-X-Gly. Depending on the degree of hydrophobicity (or solvation), the values of the percentages exposed to the solvent are divided by less than 10%, 10-50%, and more than 50%, respectively, buried (Buried, denoted B below). , In the middle (MEDIUM, hereinafter referred to as M), and exposed (expected, hereinafter referred to as E) three classes.

After classifying amino acids according to these local environments, the 3D structural information of the sequence is transformed into 1D strings of local environmental covariates. The amino acid sequence can be expressed as a set of {(i, m)} of the protein (conformation) in a given structure.

Therefore, in the present invention considering the angle of Ramachand, it has 81 × 9 = 729 local environments.

Given a given amino acid sequence, a score function is needed to know which of the protein's natural and decoy structures fits well.

In the first embodiment of the present invention, the rough grainy expression of amino acids and the propensity for the amino acids to lie in different local environments have been introduced.

We have constructed a score function for the tendency of amino acids to be placed in different local environments, and the basic way to optimize these tendencies is to ensure that the score when the sequence is in its natural structure is always lower than the score when it is in the competitive structure. .

The above criteria should also be applied simultaneously to sets containing many proteins.

The score function for a protein in consideration of the local environment including the 20 amino acids and the lamachandran angle may be expressed by Equation 1 below.

Where H is a score function that quantitatively measures how stable the sequence s is in the structure Γ. And n (i, m) is the number of amino acids in the m local environment where the amino acid of the form i is in 9 environments and the Φ-Ψ matrix, and ε (i, m) is the score parameter associated with this amino acid.

Normally given the structure of the protein, n (i, m) is determined from the PDB file. Then, the present invention extracts 14,580 ε (i, m) score parameters represented by a 20 × 729 matrix which ensures to recognize the most stable natural structure with respect to the set of decoy structures.

As described above, the 7.8 million training decoy structural protein groups obtained by using the 1,006 training protein group and the 1,006 training protein group, each decoy structure stabilizes the natural structure of all 1,006 training proteins. In order to satisfy the following equation (2) must be satisfied.

Where n (i, m) ^D and n (i, m) are decoy structures (D = 1,2, ..... 78.2 million), respectively, and the i-type amino acids in the natural structure of the The number of cases in which m is a local environment of the m-? Matrix, which is determined from the PDB file, as described above.

Thus, using Equation 2 above, 180 score parameters of ε (i, m) are obtained so that 1,006 trained proteins with known natural structures will always have a lower score than when their sequences were placed in the decoy structure. Must be determined and optimized.

The general way to solve ε (i, m) is to find a value that satisfies Equation (2) for D = 1,2, ..... 78.2 million simultaneously in a variable space of 14,580 dimensions.

Equation 2 may be expressed by Equation 3 below.

here Is a known and fixed value for 1,006 training protein groups Is the value to determine as an unknown vector.

Initial value in the present invention For all 78.2 million inequalities, starting from Wow The scalar product of was calculated and the calculation process is as follows.

n ₁ ¹ ε ₁ + n ₂ ¹ ε ₂ + n ₃ ¹ ε ₃ + ............................... n _14,580 ¹ ε _14,580 〉 0

n ₁ ² ε ₁ + n ₂ ² ε ₂ + n ₃ ² ε ₃ + ............................... n _14,580 ² ε _14,580 〉 0

........................................ ........

n ₁ ¹⁰⁰ ε ₁ + n ₂ ¹⁰⁰ ε ₂ + n ₃ ¹⁰⁰ ε ₃ + ............ n _14,580 ¹⁰⁰ ε _14,580 〉 0

........................................ ............>0

Calculate approximately 78,2 million inequalities above to find ε ₁ , ε ₂ , ........ ε _14,580 .

Where the score gap Is negative This decoy structure is called a failed decoys because it does not satisfy the above inequality.

In the present invention, the worst vector giving the lowest score interval among failed decoy structures. Select to increase the score interval for the worst decoy ｗ. Updated as follows:

78.2 million scalar products Recalculate for, then find the set of failed decoy structures and the worst decoy structure To renew Obtain

This process is repeated until the number of failed decoy structures out of 78.2 million decoy structures is zero. The main reason for this update is to ensure that the score in the natural structure is stabilized relative to the scores in the decoy structures in order to fully recognize the natural structure state. To find.

If there is a solution to equation (2), i.e. If all this satisfies 78.2 million inequalities, then vector Will converge to the area of certain points in the 14,580-dimensional concluding variable space, and the worst decoy structure score interval Will have a finite positive value after a finite number of iterations.

If the repetition continues forever If you do not give a convergence value or do not give a finite positive score interval, then it is not suitable for neural network learning in the sense that there is no solution or that the covariance of the score function is not appropriate.

However, it is also impractical to solve all 78.2 million inequalities at the same time, so we want to find the optimal ε (i, m) that satisfies Equation 2 using another method.

In the present invention, the following constraint is added to obtain the optimal ε (i, m).

First, the score of the natural structure of a given protein must be lower than the average score of a random sequence with a certain amino acid composition on its own natural structure.

Second, the score of the natural structure of a given protein will impose a condition that it must always be lower than the average score of its own sequence on the decoy structure.

1,006 and 1,005 inequalities are generated that satisfy the above two conditions.

The inequality is represented in the form as shown in Equation 5 below.

c ₁ ¹ ε ₁ + .................................... + c _14,580 ¹ ε _14,580 〉 0

........................................ .......

c ₁ ¹⁰⁰⁶ ε ₁ + ......................... + c _14,580 ¹⁰⁰⁶ ε _14,580 〉 0

d ₁ ¹ ε ₁ + ......................................... + d _14,580 ¹ ε _14,580 〉 0

........................................ ......

d ₁ ¹⁰⁰⁵ ε ₁ + ......................... + d _14,580 ¹⁰⁰⁵ ε _14,580 〉 0

Wherein c, d about the value that will be obtained from the PDB file represents the same year ε _1, ....... value of ε _14,580 of solving the inequality of the neural network 2011 to the study, 14,580-dimensional variable maeteum The value of the score parameter ε (i, m) can be found.

Using the score parameter ε (i, m) obtained above, the scores of all 78.2 million decoy structures are compared with the scores in the natural structure state, that is, whether Equation 2 is satisfied for all decoy structures. Perform a threading test to verify.

However, as a result of threading test of 78.2 million decoy structures using the ε (i, m) obtained in the present invention, the number of failed decoy structures giving a lower value than the scores of natural structures is 1,628 out of 78.2 million. The dog was calculated.

The inequality obtained from the failed decoy structure is generated by using the score parameter vector updated in the above manner, generating 1,628 new inequality equations, adding them to the previous 2,011 inequality equations, and then performing neural network training again using all 3,639 inequality equations. Solve for the new ε (i, m).

The above process attempts to maximize the stability of natural structural states for competing decoy structures by maximizing the score interval between the natural and failed decoy structures of 1,006 training proteins.

Now, in the second threading test using the newly obtained ε (i, m), new failed decoy structure sets were created and added to the previous inequality.

In the present invention, as described above, it was repeated until the number of failed decoy structures to be added to (i) neural network learning to update the score covariate and (ii) protein threading to add a new inequality becomes zero. The number of generated inequalities is 3,998 until this process is continued to satisfy Equation 2 for all decoy structures.

Although the solution ε (i, m) satisfies all 78.2 million inequalities by solving 3,998 inequalities, the solution is neither unique nor optimized.

One way to optimize ε (i, m) is to boost the scores of decoy structures that compete to maximize stabilization of the natural structure of the 1,006 training proteins, as far as possible from the scores of the natural structure. .

To this end, in the present invention, the decoy structures compete for decoy structures with a score interval between all 78.2 million decoy structures and each protein's natural structure score less than 3,998 decoy structures and a minimum score interval between each protein's natural structures. Left.

The inequality of these competing decoy structures was added to the previous 3,998 inequalities to obtain an optimized solution ε (i, m).

In addition, the neural network learning and protein threading process was repeatedly performed until the number of additional competitive decoy structures became 0. As a result, 4,539 inequalities can recognize 100% of the natural structure of 1,006 training proteins. We were able to optimize monolithic score covariates including 14,580 Ramatandran angles.

The score parameters of the 14,580 score coherence variables obtained and optimized above are shown in Table 2. Table 2 is attached at the end of the composition of the invention in quantity.

Where H is α-helix, S is β-strand, L is loop structure, B is buried, M is middle, E is exposed, psi1, phi1 is Ramachandran plot In the range from -180 ° to -140 °.

By repeating the process of neural network learning and protein threading, the monolithic score parameter of the protein was obtained as shown in Table 2, and the above-described score parameter was used to verify the natural structure recognition ability of new proteins.

For the verification, a new protein group should be selected. The new protein / new protein group was selected with the same selection conditions as the training protein group selected above, having a homology of less than 90%, and distinct from the training proteins. The total number of proteins in the new protein group that satisfies the selection condition was 412, which is shown in Table 3 below.

<Table 3>

412 New Protein Family

1A58, 1A7W, 1A80, 1A8B, 1A8Q, 1AAY, 1AK2, 1ALA, 1AMW, 1ANU, 1APA, 1ARV, 1AUN, 1AVK, 1AW9, 1AWD, 1AX0, 1AYX, 1AZP, 1B1U, 1B4V, 1BP, 1B7DG 1BED, 1BET, 1BFS, 1BGP, 1BIK, 1BLU, 1BMG, 1BOY, 1BQ8, 1BQB, 1BR6, 1CBG, 1CDW, 1CF3, 1CIU, 1CKT, 1CNU, 1CO6, 1COT, 1CPN, 1CSP, 1CV2, 1CW0C 1CZN, 1DF7, 1DOT, 1DP6, 1DSL, 1DUW, 1DVE, 1DWT, 1DXH, 1DYR, 1DYZ, 1E0S, 1E0W, 1E9L, 1E9M, 1EBB, 1EDO, 1EE6, 1EFY, 1EIR, 1EJ2, 1EK8, 1EK8, 1EK8, 1EQJ, 1ESW, 1EUO, 1EX1, 1EXM, 1EXS, 1EYL, 1EYT, 1F0N, 1F1S, 1F2J, 1F2V, 1F3Z, 1F7U, 1FA2, 1FBL, 1FD9, 1FEH, 1FH9, 1FNL, 1FP2, 1FWF1Z 1FW8, 1FYN, 1G0C, 1G12, 1G3Q, 1G3U, 1G43, 1G6H, 1G8O, 1G94, 1G96, 1GBG, 1GC5, 1GCU, 1GH2, 1GJW, 1GOJ, 1GSM, 1H6U, 1H98, 1H9O, 1HBZH 1HEY, 1HG8, 1HI2, 1HIZ, 1HJO, 1HLR, 1HLV, 1HPI, 1HPT, 1HQ8, 1HSK, 1HUP, 1HUQ, 1HVX, 1HW7, 1I37, 1I39, 1I3J, 1I52, 1I5P, 1I71, 1I7P, 1I92 1IAP, 1IAT, 1IDK, 1IG5, 1IG7, 1IG8, 1IHK, 1IIZ, 1IKT, 1ILE, 1IO2, 1IQR, 1IVD, 1J75, 1J77, 1J93, 1JCV, 1JDL, 1JF0, 1JF9, 1JGS, 1JH8, 1JIL, 1JIP, 1JJ7, 1JL5, 1JSG, 1JWO, 1JX6, 1JY8, 1K04, 1K1A, 1KAS, 1KBL, 1KDJ, 1KEA, 1KR5, 1KS9, 1LKLP 1LZR, 1MHO, 1MNP, 1MRG, 1MUP, 1NAT, 1NCX, 1NDT, 1NOA, 1NPC, 1NPL, 1NTN, 1PBK, 1PCH, 1PGX, 1PI2, 1PMT, 1PMY, 1POH, 1PPO, 1PTR, 1PVX, 1QW0Q 1QM7, 1QTF, 1QTR, 1QUE, 1RCD, 1RDS, 1RPJ, 1RRO, 1SAT, 1SBF, 1STE, 1SZT, 1TGJ, 1THM, 1THX, 1TMO, 1UDC, 1UDH, 1UNE, 1VJW, 1VPE, 1WAD, 1XAA, 1YAT 1A2O, 1AFS, 1AG9, 1AKE, 1AN9, 1AOR, 1AVB, 1B43, 1B88, 1BEH, 1BJF, 1BSR, 1BU5, 1BWO, 1CBK, 1CDO, 1CFY, 1CNS, 1CQM, 1D8U, 1DD6, 1DEH, 1DDDN 1DUG, 1DVI, 1E5D, 1EE8, 1EKF, 1EL5, 1EP7, 1EQT, 1F1C, 1F1Z, 1F2K, 1F5J, 1FDQ, 1FJR, 1FMC, 1FON, 1FSL, 1FTP, 1FZV, 1FZY, 1G1C, 1G61C, G 1GGL, 1HQL, 1HRO, 1I3D, 1I8J, 1IBJ, 1IHB, 1IHF, 1IT2, 1J7L, 1JFG, 1JOC, 1JUO, 1JZA, 1KEW, 1KFI, 1KXI, 1LFA, 1QGJ, 1QM5, 1RAV, 1RPM, 1EV, 1RPM 1XGS, 1XYZ, 1AD1, 1AGD, 1AWC, 1B7Y, 1BAI, 1BHD, 1BLX, 1BUN, 1BYO, 1BZ7, 1C1Y, 1C3A, 1CG5, 1CK4, 1D1P , 1DEA, 1DJN, 1DK7, 1DS7, 1DTD, 1DWV, 1DY7, 1DZR, 1E3I, 1E55, 1E7A, 1ED8, 1EDY, 1EHI, 1EMU, 1EP3, 1F06, 1F08, 1FE0, 1FEC, 1FEU, 1FMJL1FR2, , 1G99, 1GAW, 1GES, 1GL4, 1GRN, 1GSU, 1H6W, 1H8U, 1HA4, 1HM6, 1HNN, 1HPO, 1I0R, 1I0Z, 1I8T, 1IB4, 1IBQ, 1IEP, 1IG3, 1II2, 1II7, 1IICIO7 , 1J7D, 1JB7, 1JD5, 1JEH, 1JIH, 1JKG, 1JQI, 1JSD, 1KHH, 1KKT, 1KNV, 1KOB, 1LEH, 1MEE, 1NIR, 1QD9, 1QFT, 1QJC, 1QK2, 1QO8, 1QEM, 1QEM, 1QEM, 1QEM , 1XBR, 1YDV, 1ZYM,

However, among the novel proteins, 30 proteins having a multi-domain, a small length, or a twisted form in the SCOP classification were excluded from the novel protein group of the present invention, which was limited to four groups which are representative structures of nature. In order to select a protein group, a total of 382 proteins in the new protein group for testing were selected.

That is, 22 small proteins (1AAY, 1B7D, 1BCG, 1BET, 1BIK, 1BQ8,1EYT, 1HPI, 1HPT, 1I71,1NTN, 1PI2,1PTR, 1QM7,1TGJ, 1DQ7,1FZV, 1G40,1JOC) , 1JZA, 1KXI, 1JD5), 7 kinds of proteins having multi-domains (1EE8, 1EKF, 1FR1, 1G0H, 1JIH, 1HBZ, 1I3J), and 1 kind of ultra-twisted protein (1SZT).

Each selected protein group was subjected to the threading method in the same manner as the method for obtaining the training decoy structural protein group for 1006 training protein groups.

Using the threading method described above, about 12.1 million decoy structures were obtained for the new protein group, and the protein having the decoy structure became the new decoy structure protein group.

Using the new protein group, the new decoy structural protein group, and the score parameters obtained above, a threading test was performed to determine whether the new protein group was satisfied with Equation 2. The total threading test result was 380 (99.5%). It has been shown that it can recognize the natural structure of dog proteins, and out of a total of 12.1 million decoy structures, there are only two failed decoy structures.

And the failed proteins are 1LG7 and 1J75.

As described above, the present invention derives a monolithic score function of a protein that stabilizes all 1,006 natural structures having a homology of less than 30%, and obtains optimal score parameters through neural network learning theory and protein threading.

The score function and score parameters were then used for threading tests on new 382 separate proteins, recognizing 380 (99.5%) natural structures out of the 382 proteins, which is a very useful method for structural stability analysis of proteins. Indicates that it can be

The above is the monolithic (Lama One Body) score function considering the Ramachandran angle environment of the protein. Next, the protein score function in the mating contact will be described.

Second Embodiment

A second embodiment of the present invention is a two-way interaction (hereinafter referred to as two-bodied) connected in such a manner as to make pairwise contact with a Ramachandran monolith (hereinafter referred to as Rama circle body) environmental variable comprising a Ramachandran angle environment. It is related to the contents of protein structure stability analysis considering all of them.

Here, it is necessary to classify the local environment of amino acids for defining the two-body score function. As for the local environment classification method for one amino acid, as in the first embodiment, nine local environments are considered, 180 score parameters Is formed.

However, the body of the present invention should be applied to two amino acids, and there are 180 score parameters for one amino acid. In the case of two, 180 × 180 score parameters exist, but the symmetry of two amino acids is used. Considering this, the overall score parameter is {(180) × (180 + 1)} / 2 = 16,290.

Therefore, we constructed a score function for the tendency of amino acids for the lamella body and two-body amino acids considering the lam Chananda angle, and considering the local environment. The constraint that the score at time is always lower than the score at the time of competition is the same as in Example 1.

The score function for a protein in consideration of the llama one body and two body at the same time 20 amino acids can be represented by the following equation (6).

Where H is a score function that quantitatively measures how stable the sequence s is in the structure Γ. And n (i, m) is the number of amino acids in the m local environment where i-type amino acids are in 9 environments and Φ-Ψ matrix, and ε (i, m) is the score parameter associated with this amino acid, n (i, j; k, l) is the number of amino acids in the local environment in which i, j-type amino acids linked in a pairwise contact are k, l, and ε (i, j; k, l) is the score parameter associated with these amino acids.

Given the structure of a protein, n (i, m) and n (i, j; k, l) are usually determined from the PDB file. Then, in the present invention, 14,580 of ε (i, m) and ε (i, j; k, l) represented by 20 × 729 and 180 × 180 matrices that ensure the recognition of the most stable natural structure for a set of decoy structures. It is to extract +16,290 score parameters.

The training protein group and the training decoy protein group used in the second embodiment are the same as those of Example 1, and about 7,80,000 training decoy structure proteins obtained using the 1,006 training protein group and the 1,006 training protein group As described above, each decoy structure must satisfy Equation 7 below to stabilize the natural structure of all 1,006 trained proteins.

Where n (i, m) ^D and n (i, m) are decoy structures (D = 1,2, ..... 78.2 million), respectively, and the i-type amino acids in the natural structure of the It is the number of cases in which m is a local environment of m type, which is a Φ-Ψ matrix, and n (i, j; k, l) ^D and n (i, j; k, l) are decoy structures (D = 1,2), respectively. , ..... 78.2 million) and the amino acid of type i, j, which is connected in pairwise contact with the protein's natural structure, is placed in the local environment of type k, l, As explained above, it is determined from the PDB file.

Thus, using Equation 7 above, ε (i, m) and ε (i, j, such that 1,006 training proteins with known natural structures always have a lower score than when their sequences were placed in the decoy structure. 14,580 + 16,290 score parameters of; k, l) should be determined and optimized.

Equation 7 may be expressed by Equation 8 below.

The process of calculating the vector expression of Equation 8 is entirely the same as in the first embodiment, except that the difference must be calculated using 14,580 score parameters as independent variables in the first embodiment. In Equation, there are 14,580 + 16,290 = 30,870 variables that differ only in parts where the inequality is to be calculated and the rest are completely the same.

As with the first embodiment, the following constraint was added instead of calculating 78.2 million inequalities.

First, the score of the natural structure of a given protein must be lower than the average score of a random sequence with a certain amino acid composition on its own natural structure.

Second, the score of the natural structure of a given protein will impose a condition that it must always be lower than the average score of its own sequence on the decoy structure.

Form 2011 inequalities consisting of 1,006 and 1,005, respectively, satisfying the above two conditions, and are independent variables and score parameters ε ₁ , ε ₂ , ε ₃ , .........., ε _14,580, The _values of ε (i, m) and ε (i, j; k, l) consisting of ... ε _16,290 , ... ε _30,870 were calculated.

Using the score parameters ε (i, m) and ε (i, j; k, l) obtained above, the scores of all 78.2 million decoy structures are compared with those of the natural structure state, i.e. all decoy structures A threading test is performed to determine whether Equation 7 is satisfied.

However, when the threading test of 78.2 million decoy structures using the ε (i, m) and ε (i, j; k, l) obtained in the present invention gives a lower value than the scores in the natural structure state. The number of failed decoy structures was calculated to be 208 out of 78.2 million.

208 inequalities obtained from the failed decoy structure are generated using the score parameter vectors updated in the same manner as in the first embodiment, and 208 new inequalities are added to the previous 2,011 inequalities and then all 2,219 inequalities are used. Neural network learning is performed again to find new solutions of ε (i, m) and ε (i, j; k, l).

Using the newly obtained ε (i, m) and ε (i, j; k, l), we create a set of newly failed decoy structures in the second threading test and update the score coherence by adding them to the previous inequality. While learning, the process of protein threading, which adds a new inequality, was repeated over and over until the number of failed decoy structures became zero.

The number of inequalities generated is 2,219 until all the decoy structures are satisfied to satisfy Equation (8).

Here, solving 2,219 inequalities, the solutions ε (i, m) and ε (i, j; k, l) satisfy all 78.2 million inequalities, but the solution is neither unique nor optimized.

By optimizing ε (i, m) and ε (i, j; k, l), the scores of decoy structures competing to maximize stabilization of the natural structure of 1,006 training proteins are obtained. Push it up as far as possible from the scores.

For this purpose, in the present invention, the decoy structures compete for decoy structures with a score interval between all 78.2 million decoy structures and each protein's natural structure score being less than 2,219 decoy structures and a minimum score interval between each protein's natural structures. Left.

Inequalities for these competitive decoy structures were added to the previous 2,219 inequalities to obtain optimized solutions ε (i, m) and ε (i, j; k, l).

In addition, the neural network learning and protein threading process was repeatedly performed until the number of additional competitive decoy structures became 0. As a result, 4,104 inequalities can recognize 100% of the natural structure state of 1,006 training proteins. The Ramadan body and 2 body score coherent variables could be optimized.

The score parameters, which are the 30,870 score coherence variables obtained and optimized above, are shown in Table 4. Table 4 is attached at the end of the configuration of the invention in quantity.

Where H is α-helix, S is β-strand, L is loop structure, B is buried, M is middle, E is exposed, psi1, phi1 is Ramachandran plot In the range from -180 ° to -140 °.

By repeating the process of neural network learning and protein threading, lamella body and two-body score parameters ε (i, m) and ε (i, j; k, l) of the protein were obtained as shown in Table 4 above. The score parameter of was used to verify the natural structure recognition ability of the new proteins.

For the verification, a new protein group should be selected. As in Example 1, about 12.1 million decoy structural protein groups were formed through the threading method using the selected 382 new protein groups, and the new protein group, Using the new decoy structural protein group and the score parameter obtained in Table 4, a threading test was performed to determine whether the new protein group satisfies Equation (7).

The threading test showed that it was able to recognize the natural structure of a total of 381 (99.7%) proteins and found that there was only one failed decoy structure out of a total of 12.1 million decoy structures. The failed protein is 1IG1

As described above, the second embodiment of the present invention derives a protein score function considering llamawon body and two-body that stabilizes all 1,006 natural structures having a homology of less than 30%, neural network learning theory and protein threading The optimal score parameter can be obtained through.

The score function and score parameter were then used in threading tests for the new 382 proteins, recognizing 381 (99.7%) natural structures out of the 382 proteins, and only one failed out of a total of 12.1 million decoy structures. The presence of only a decoy structure indicates that it can be used as a very useful method for structural stability analysis of proteins, and it can be seen that the second example which considers the llama one body and the two body simultaneously is the best analytical method.

<Table 2>

14,580 Rama One-Body Score Parameters including Ramachandran Angle

CysHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.007 0.002 0.002 0.000 0.000 0.001 0.010 0.000 0.000

psi2 0.000 0.000 0.005 0.000 0.000 0.003 0.002 0.000 0.000

psi3 0.001 0.015 0.180 0.086 0.001 0.000 0.000 0.000 0.000

psi4 0.005 -0.047 -3.031 -3.347 0.000 0.000 0.000 0.001 0.000

psi5 0.007 -1.038 -1.752 0.093 0.000 0.000 0.004 0.007 0.000

psi6 0.002 0.065 0.019 0.006 0.000 -0.025 0.069 0.000 0.000

psi7 0.008 -0.344 -0.170 0.000 0.000 0.000 0.000 0.000 0.000

psi8 -1.157 -0.987 0.031 0.015 0.000 0.000 0.000 0.007 0.000

psi9 0.043 0.008 -1.415 0.002 0.000 0.000 0.002 0.001 0.000

CysHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.008 0.239 0.025 0.000 0.000 0.001 0.011 0.006 0.000

psi2 0.000 0.000 0.001 0.000 0.000 0.012 0.033 0.000 0.000

psi3 0.000 -0.444 0.033 -0.126 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -1.629 2.658 6.390 0.016 0.000 0.001 0.000 0.002

psi5 0.001 2.040 1.821 0.579 0.000 0.001 0.020 0.002 0.000

psi6 0.001 0.040 0.333 0.000 0.000 0.025 -0.027 0.000 0.000

psi7 0.029 0.165 -0.228 0.010 0.000 0.006 0.000 0.000 0.000

psi8 0.034 0.062 -0.071 0.558 0.000 0.000 0.001 0.000 0.000

psi9 0.055 0.716 0.303 0.018 0.000 0.000 0.023 0.014 0.000

Cyshe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.010 0.000 0.000 0.000 0.001 0.000 0.000

psi2 0.000 0.008 0.000 0.000 0.005 0.018 0.005 0.000 0.000

psi3 0.005 0.067 0.390 0.255 0.009 0.001 0.000 0.000 0.000

psi4 0.368 -0.401 5.357 0.881 0.005 0.000 0.001 0.000 0.000

psi5 0.000 0.412 1.799 0.072 0.000 0.000 0.122 0.001 0.000

psi6 0.006 0.026 0.018 0.000 0.000 0.071 0.059 0.000 0.000

psi7 0.007 0.002 0.009 0.000 0.000 0.212 0.000 0.000 0.000

psi8 0.000 0.216 0.121 0.019 0.000 0.000 0.000 0.000 0.000

psi9 0.001 0.003 0.354 0.032 0.000 0.000 0.001 0.000 0.000

CysSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.085 -0.155 0.010 0.000 0.000 0.000 0.002 0.010 0.074

psi2 0.004 0.002 0.000 0.002 0.000 0.000 0.001 0.001 0.001

psi3 0.000 0.001 0.001 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.036 0.033 0.002 0.000 0.000 0.000 0.000 0.000

psi5 0.000 -0.121 0.004 0.005 0.000 0.000 0.006 0.000 0.000

psi6 0.005 0.002 0.008 0.000 0.000 0.007 0.000 0.000 0.000

psi7 0.004 -0.172 0.168 0.000 0.000 0.000 0.000 0.000 0.000

psi8 -0.489 -1.639 0.346 0.033 0.000 0.000 0.000 0.000 0.076

psi9 -0.541 -6.096 -2.800 0.021 0.000 0.000 0.000 0.010 0.017

CysSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.693 0.057 0.028 0.000 0.000 0.000 0.016 0.331 0.049

psi2 0.005 0.000 0.000 0.000 0.000 0.000 0.005 0.000 0.000

psi3 0.000 0.001 0.007 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.034 0.099 0.010 0.000 0.000 0.000 0.000 0.000

psi5 0.000 -0.106 0.018 0.000 0.000 0.000 0.180 0.000 0.000

psi6 0.000 0.014 0.010 0.000 0.000 0.008 0.006 0.000 0.000

psi7 0.024 0.072 0.392 0.000 0.000 0.000 0.000 0.000 0.014

psi8 0.191 1.584 -2.572 0.279 0.000 0.000 0.000 0.000 0.018

psi9 -1.633 -0.427 -0.883 0.015 0.000 0.000 0.012 0.006 0.042

Cysse

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.010 0.019 0.006 0.000 0.000 0.000 0.001 0.000 0.000

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.217 0.022 0.002 0.000 0.000 0.001 0.000 0.000

psi5 0.005 0.013 0.031 0.000 0.000 0.000 0.024 0.000 0.000

psi6 0.000 0.013 0.000 0.000 0.000 0.011 0.008 0.000 0.000

psi7 0.006 0.016 0.016 0.000 0.000 0.000 0.000 0.000 0.005

psi8 0.058 0.386 -0.478 0.050 0.000 0.000 0.000 0.000 0.005

psi9 0.103 0.154 0.253 0.037 0.000 0.000 0.000 0.000 0.000

Cyslb

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.161 0.056 -0.107 0.005 0.000 0.005 0.034 0.007 0.030

psi2 0.002 0.027 0.002 0.000 0.005 0.007 0.008 0.001 0.001

psi3 0.001 0.037 0.073 0.006 0.000 0.000 0.001 0.005 0.000

psi4 -0.096 -2.022 -0.726 -0.077 0.000 0.000 0.014 0.029 0.037

psi5 0.015 -1.882 -3.767 0.012 0.000 0.001 0.402 0.092 0.000

psi6 0.018 -0.447 -0.107 0.002 0.000 -0.413 0.264 0.001 0.000

psi7 -0.332 -0.911 0.847 0.004 0.000 -0.492 0.002 0.001 0.000

psi8 0.058 -1.986 -4.404 -1.251 0.000 0.005 0.008 0.003 0.006

psi9 -0.514 -3.384 -1.560 1.052 0.000 0.000 0.017 0.035 0.030

Cyslm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.018 0.114 0.135 0.006 0.000 0.006 0.135 0.095 0.055

psi2 0.006 -0.426 0.029 0.006 0.000 0.013 0.015 0.003 0.006

psi3 0.012 0.103 -0.058 0.063 0.010 0.004 0.019 0.000 0.005

psi4 0.017 0.207 0.406 -0.288 0.002 0.000 0.302 0.072 0.014

psi5 0.028 -3.510 -1.598 0.178 0.000 0.015 0.589 0.057 0.003

psi6 0.036 0.167 0.101 0.000 0.000 0.772 0.570 0.003 0.000

psi7 0.048 3.201 -0.912 0.019 0.003 0.044 0.042 0.008 0.007

psi8 0.610 -1.922 -7.448 0.205 0.003 0.000 0.028 0.006 0.028

psi9 -0.241 1.027 -0.225 1.722 0.006 0.002 0.368 0.080 0.045

Cysle

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.050 0.075 -0.793 0.000 0.000 0.003 0.028 0.002 0.006

psi2 0.006 0.016 0.008 0.002 0.002 0.027 0.068 0.006 0.005

psi3 0.019 -0.062 0.115 0.229 0.007 0.003 0.038 0.014 0.001

psi4 0.023 0.410 3.077 1.522 0.014 0.005 0.092 0.045 0.007

psi5 0.144 2.154 2.148 0.157 0.002 0.029 1.789 0.340 0.009

psi6 0.057 -0.756 0.249 0.078 0.006 1.026 1.461 0.002 0.011

psi7 -0.463 0.307 1.198 0.030 0.008 -0.735 0.045 0.002 0.000

psi8 -0.789 2.335 3.112 1.621 0.011 0.009 0.013 0.000 0.016

psi9 -0.431 0.998 3.099 0.477 0.000 0.000 0.012 0.002 0.006

PheHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.012 0.003 0.004 0.000 0.000 0.002 0.508 0.000 0.000

psi2 0.001 0.001 0.011 0.000 0.000 0.007 0.003 0.000 0.000

psi3 0.002 0.062 -2.891 -1.602 0.001 0.000 0.000 0.000 0.000

psi4 0.014 -1.140 -5.214 -5.078 0.000 0.000 0.000 0.002 0.000

psi5 0.015 -0.841 -3.304 0.173 0.000 0.000 0.007 0.008 0.000

psi6 0.042 -0.189 0.017 -0.185 0.000 0.452 0.008 0.000 0.000

psi7 -0.072 -0.141 0.052 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.019 -0.312 0.087 0.030 0.000 0.000 0.001 0.011 0.000

psi9 0.020 -0.075 -0.103 -0.013 0.000 0.000 0.004 0.003 0.001

PheHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.013 0.103 0.029 0.000 0.000 0.001 0.017 0.010 0.000

psi2 0.000 0.001 0.002 0.000 0.000 0.018 0.018 0.000 0.000

psi3 0.001 0.003 1.215 -0.379 0.001 0.000 0.000 0.000 0.000

psi4 0.000 -1.106 -1.100 0.892 0.028 0.000 0.001 0.001 0.015

psi5 0.001 -0.326 1.498 1.770 0.000 0.005 0.399 0.065 0.000

psi6 0.002 -1.816 0.310 0.000 0.000 -0.006 0.015 0.000 0.000

psi7 0.129 -0.111 0.521 0.009 0.000 0.015 0.000 0.000 0.000

psi8 0.146 -0.130 -0.201 0.111 0.000 0.000 0.001 0.001 0.000

psi9 0.170 0.101 1.045 0.032 0.000 0.000 0.033 0.014 0.001

PheHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.358 0.000 0.000 0.001 0.002 0.000 0.000

psi2 0.000 0.007 0.000 0.000 0.041 0.012 0.003 0.000 0.000

psi3 0.012 0.008 0.293 1.065 0.025 0.002 0.000 0.000 0.001

psi4 -0.776 0.539 8.797 0.780 0.042 0.000 0.002 0.000 0.000

psi5 0.001 -0.900 0.766 0.538 0.000 0.001 -0.418 0.002 0.001

psi6 0.005 0.659 0.058 0.000 0.000 0.054 0.041 0.001 0.000

psi7 0.007 0.274 -0.190 0.000 0.000 0.010 0.000 0.000 0.000

psi8 0.000 0.024 0.066 0.009 0.000 0.001 0.000 0.000 0.000

psi9 0.257 0.006 0.676 0.039 0.000 0.000 0.001 0.000 0.000

PheSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.113 0.102 0.063 0.000 0.000 0.000 0.003 0.020 0.189

psi2 0.003 0.014 0.000 0.013 0.000 0.000 0.001 0.002 0.006

psi3 0.000 0.001 0.001 0.000 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.102 0.092 0.003 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.085 0.009 0.042 0.000 0.000 0.048 0.000 0.000

psi6 0.042 0.006 0.011 0.000 0.000 0.012 0.001 0.000 0.000

psi7 0.007 0.377 -0.121 0.000 0.000 0.002 0.000 0.000 0.000

psi8 0.682 0.315 0.035 0.074 0.000 0.000 0.000 0.000 0.001

psi9 -4.306 -2.820 -0.745 -0.053 0.000 0.000 0.000 0.006 0.044

PheSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.443 -0.251 -0.689 0.000 0.000 0.000 0.059 0.031 0.160

psi2 0.075 0.000 0.000 0.000 0.000 0.000 0.223 0.000 0.000

psi3 0.000 0.001 0.015 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.084 0.236 0.020 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.146 0.019 0.000 0.000 0.000 0.002 0.018 0.000

psi6 0.000 0.440 0.047 0.000 0.000 0.015 0.006 0.000 0.000

psi7 0.186 -0.595 -0.382 0.000 0.000 0.000 0.000 0.000 -0.693

psi8 1.527 -2.694 -0.160 0.091 0.002 0.000 0.000 0.000 0.152

psi9 -3.408 -0.335 0.415 0.186 0.000 0.000 0.053 0.032 -0.758

PheSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.083 0.064 0.010 0.000 0.000 0.000 0.003 0.000 0.001

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.191 0.180 0.003 0.000 0.000 0.002 0.000 0.000

psi5 0.041 0.012 0.030 0.000 0.000 0.000 -1.287 0.000 0.000

psi6 0.002 0.007 0.000 0.000 0.000 0.016 0.013 0.000 0.000

psi7 0.062 -0.017 0.111 0.000 0.000 0.000 0.000 0.000 0.041

psi8 0.430 0.987 1.783 0.079 0.000 0.000 0.000 0.000 0.041

psi9 0.045 0.310 -0.836 0.209 0.000 0.000 0.000 0.000 0.000

PheLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.150 0.188 0.763 0.013 0.000 0.019 0.048 0.025 0.163

psi2 0.006 0.060 0.004 0.002 0.041 0.025 0.012 0.002 0.001

psi3 0.002 -0.124 -0.120 -0.025 0.000 0.000 0.002 0.042 0.000

psi4 0.007 -1.575 -1.615 -0.310 0.000 0.000 0.037 0.035 0.003

psi5 0.034 1.032 -1.892 0.036 0.000 0.002 0.371 0.091 0.001

psi6 0.034 -0.074 -0.749 0.013 0.000 1.080 0.066 0.004 0.000

psi7 0.146 -1.022 0.301 0.027 0.000 0.028 0.004 0.002 0.000

psi8 -1.465 0.193 -0.644 -0.379 0.000 0.015 0.038 0.005 0.044

psi9 -3.487 -1.459 0.093 0.560 0.000 0.000 0.096 0.186 0.129

PheLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.470 0.319 0.825 0.013 0.000 0.019 0.106 0.105 0.097

psi2 0.108 0.061 0.109 0.012 0.001 0.045 0.037 0.005 0.011

psi3 0.054 0.053 0.084 -0.803 0.063 0.030 0.073 0.000 0.042

psi4 0.049 0.503 1.131 0.891 0.013 0.000 0.120 0.064 0.041

psi5 0.084 -6.484 1.320 0.136 0.000 -0.067 1.119 0.657 0.014

psi6 0.517 -0.773 -1.093 0.001 0.000 0.613 0.840 0.018 0.000

psi7 -4.686 -0.234 -1.492 0.053 0.014 0.159 0.078 0.024 0.025

psi8 -0.394 -1.600 2.364 1.182 0.015 0.000 0.119 0.013 0.080

psi9 0.800 -2.779 2.952 0.437 0.013 0.013 0.182 0.058 0.075

PheLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.088 0.257 0.123 0.000 0.000 0.341 0.243 0.003 0.031

psi2 0.026 0.032 -0.468 0.014 0.007 0.179 0.098 0.017 0.042

psi3 0.324 0.491 0.183 0.220 0.012 0.016 0.167 0.028 0.002

psi4 0.062 0.320 3.510 1.854 0.011 0.044 0.740 0.081 0.353

psi5 0.129 2.515 -0.340 0.183 0.004 0.107 1.246 0.182 0.032

psi6 0.541 1.040 0.313 0.077 0.005 2.155 1.168 0.004 0.026

psi7 0.432 0.426 -0.122 0.070 -0.231 0.134 0.141 0.017 0.001

psi8 0.159 0.570 1.824 0.871 -0.167 0.021 0.070 0.001 0.066

psi9 -0.552 -4.338 0.941 0.666 0.000 0.000 0.021 0.006 0.044

LeuHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.022 -0.022 0.011 0.001 0.000 0.008 0.037 0.001 0.001

psi2 0.004 0.002 0.035 0.000 0.001 0.021 0.006 0.001 0.000

psi3 0.006 0.059 -0.400 -3.306 0.038 0.000 0.000 0.000 0.000

psi4 0.034 -0.855 -7.121 -6.539 0.000 0.000 0.001 0.006 0.000

psi5 0.034 0.645 -6.206 0.601 0.000 0.000 0.023 0.019 0.000

psi6 -2.636 -0.450 -0.370 0.019 0.000 0.030 0.026 0.000 0.000

psi7 0.029 0.180 -0.522 0.000 0.000 0.002 0.000 0.000 0.000

psi8 0.024 -0.083 0.213 0.239 0.000 0.000 0.003 0.018 0.001

psi9 0.049 0.044 -1.452 0.016 0.000 0.000 0.013 0.007 0.003

LeuHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.024 -0.477 0.061 0.000 0.000 0.003 0.412 0.027 0.001

psi2 0.000 0.002 0.005 0.000 0.000 0.039 0.034 0.000 0.000

psi3 0.004 0.009 0.119 -1.996 0.002 0.000 0.000 0.000 0.000

psi4 0.001 -0.148 -4.974 -3.223 0.078 0.000 0.003 0.001 0.028

psi5 0.004 -1.479 1.011 2.620 0.000 0.008 0.752 1.268 0.001

psi6 0.006 0.434 1.450 0.000 0.000 -0.111 1.527 0.000 0.000

psi7 0.488 0.126 0.179 0.029 0.000 0.033 0.001 0.001 0.000

psi8 0.353 0.218 0.323 0.117 0.000 0.000 0.003 0.002 0.000

psi9 0.816 0.802 1.780 0.076 0.000 0.000 0.530 0.032 0.002

LeuHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.003 0.018 0.001 0.000 0.002 0.650 0.000 0.000

psi2 0.000 -0.169 0.000 0.000 0.051 0.026 0.010 0.000 0.000

psi3 0.025 0.016 -0.049 3.188 0.146 0.006 0.001 0.000 0.002

psi4 0.131 -1.903 -4.158 3.034 0.052 0.000 0.005 0.001 0.000

psi5 0.002 -0.357 -3.424 0.772 0.000 0.003 0.241 0.005 0.004

psi6 -0.835 -2.426 -0.538 0.000 0.000 0.119 0.093 0.002 0.000

psi7 0.014 1.082 0.026 0.000 0.000 0.026 0.000 0.000 0.000

psi8 0.001 0.032 0.357 0.006 0.000 -0.086 0.000 0.000 0.000

psi9 0.136 0.017 0.550 0.082 0.000 0.000 0.003 0.000 0.000

LeuSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.367 -0.186 -0.716 0.000 0.000 0.000 0.010 0.063 0.781

psi2 0.009 0.030 0.000 0.027 0.000 -0.022 0.004 0.006 0.012

psi3 0.001 -0.020 0.004 0.002 0.000 0.000 0.003 0.000 0.000

psi4 0.000 0.082 -1.558 0.010 0.000 0.000 0.000 0.000 0.000

psi5 0.002 0.480 0.024 0.052 0.000 0.000 0.061 0.000 0.000

psi6 0.054 0.016 0.013 0.002 0.000 0.014 0.002 0.000 0.000

psi7 0.020 0.058 0.066 0.001 0.000 0.003 0.000 0.000 0.000

psi8 1.004 -4.535 -2.757 0.008 0.000 0.000 0.000 0.000 0.003

psi9 2.835 -1.162 -1.653 0.144 0.000 0.000 0.001 0.020 0.090

LeuSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.514 0.954 0.676 0.000 0.000 0.000 0.030 0.054 0.201

psi2 0.075 0.001 0.000 0.000 0.000 0.000 0.013 0.000 0.000

psi3 0.000 0.003 0.031 0.001 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.147 -1.507 -1.175 0.000 0.000 0.000 0.000 0.000

psi5 0.000 -0.666 -0.241 0.002 0.000 0.000 0.007 0.000 0.000

psi6 0.001 0.071 0.062 0.000 0.000 0.262 0.012 0.000 0.000

psi7 0.212 -0.075 -0.258 0.000 0.000 0.001 0.001 0.000 0.152

psi8 -1.342 1.145 -2.031 -0.091 0.004 0.000 0.000 0.001 0.208

psi9 4.119 -0.791 -2.717 -0.287 0.000 0.000 0.071 0.415 0.101

LeuSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.104 0.126 0.008 0.000 0.000 0.000 0.008 0.000 0.002

psi2 0.001 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.000 0.001 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.381 0.665 0.009 0.000 0.000 0.182 0.000 0.000

psi5 0.051 0.465 -0.060 0.000 0.000 0.001 0.017 0.000 0.000

psi6 0.004 0.017 0.001 0.000 0.000 0.020 0.021 0.000 0.000

psi7 0.444 0.127 0.119 0.000 0.000 0.001 0.000 0.000 0.051

psi8 -0.360 3.144 -0.968 0.380 0.000 0.000 0.000 0.000 0.051

psi9 -0.297 0.828 0.279 0.280 0.000 0.000 0.000 0.000 0.001

LeuLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.159 0.439 0.434 0.032 0.000 0.045 0.322 0.062 0.049

psi2 0.016 0.135 0.013 0.005 0.051 0.125 0.036 0.005 0.004

psi3 0.007 0.170 -0.102 0.055 0.000 0.000 0.006 0.052 0.001

psi4 0.017 0.102 -1.153 -0.787 0.000 0.003 -0.021 0.131 0.009

psi5 0.153 -0.712 -0.808 0.123 0.000 -0.031 -0.144 0.195 0.003

psi6 0.080 0.093 -5.021 0.029 0.000 -0.293 0.381 0.011 0.000

psi7 0.013 0.145 -0.665 0.059 0.003 -0.098 0.014 0.005 0.001

psi8 0.047 0.137 -2.984 -0.690 0.001 0.030 -0.503 0.106 -0.759

psi9 2.375 -0.289 -0.292 0.864 0.000 0.001 0.133 0.076 0.540

LeuLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.157 0.507 1.157 0.033 0.000 -0.230 0.557 0.196 0.210

psi2 0.040 0.116 -0.857 0.031 0.004 0.166 0.858 0.007 0.030

psi3 0.079 -0.168 -0.162 0.021 -0.728 0.056 0.249 0.000 0.052

psi4 0.098 -0.287 -3.092 -2.170 0.029 0.000 0.075 0.389 0.061

psi5 0.887 0.990 -1.280 0.073 0.001 -0.221 2.618 0.318 0.118

psi6 0.251 1.654 0.504 0.002 0.002 1.464 1.134 0.036 0.001

psi7 0.274 -1.901 -0.311 -0.734 0.032 0.262 0.171 0.057 0.059

psi8 -0.995 -1.752 1.040 0.036 0.034 0.001 0.885 0.031 0.145

psi9 1.391 -1.292 -0.068 1.664 0.032 0.028 0.607 0.202 0.232

Leule

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.093 0.233 0.431 0.002 0.034 0.156 0.131 0.009 0.065

psi2 0.111 0.347 0.049 0.029 0.011 0.370 0.250 0.035 0.052

psi3 0.232 -0.497 0.414 0.510 0.032 0.037 0.428 -0.229 0.005

psi4 0.154 -0.668 3.417 -0.299 0.034 0.053 0.764 0.172 0.051

psi5 0.267 -0.674 3.843 -0.065 0.002 -0.033 2.656 0.652 0.059

psi6 1.103 -0.959 0.678 0.126 0.026 1.892 3.319 -0.078 0.058

psi7 -0.885 1.520 2.084 -0.246 0.090 -0.491 0.200 0.033 0.002

psi8 -0.858 -1.551 0.497 2.416 0.058 0.057 0.091 0.003 0.201

psi9 1.400 -0.255 1.019 1.331 0.000 0.000 0.039 0.013 0.059

TrpHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.013 0.001 0.002 0.000 0.000 0.001 0.016 0.000 0.000

psi2 0.001 0.000 0.006 0.000 0.000 0.003 0.001 0.000 0.000

psi3 0.001 0.007 -2.746 -0.744 0.012 0.000 0.000 0.000 0.000

psi4 0.004 0.036 -2.349 -3.853 0.000 0.000 0.000 0.001 0.000

psi5 0.007 0.287 0.346 0.066 0.000 0.000 0.003 0.001 0.000

psi6 0.002 0.040 0.033 0.003 0.000 0.005 0.004 0.000 0.000

psi7 -0.261 -0.016 0.018 0.000 0.000 0.000 0.000 0.000 0.000

psi8 0.002 -0.009 0.175 0.017 0.000 0.000 0.000 0.013 0.000

psi9 0.006 0.006 -0.348 0.003 0.000 0.000 0.002 0.001 0.000

TrpHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.014 0.006 0.023 0.000 0.000 0.000 0.018 0.005 0.000

psi2 0.000 0.000 0.001 0.000 0.000 0.005 0.009 0.000 0.000

psi3 0.000 0.001 0.173 -0.306 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.137 -1.045 -0.597 0.011 0.000 0.000 0.000 0.001

psi5 0.001 -0.246 -2.452 0.195 0.000 0.001 0.028 0.002 0.000

psi6 0.001 -0.178 0.061 0.000 0.000 0.030 0.007 0.000 0.000

psi7 0.361 0.025 -0.181 0.004 0.000 0.008 0.000 0.000 0.000

psi8 0.007 0.032 0.280 0.038 0.000 0.000 0.000 0.000 0.000

psi9 0.031 0.083 0.242 0.012 0.000 0.000 0.029 0.002 0.000

TrpHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.008 0.000 0.000 0.000 0.001 0.000 0.000

psi2 0.000 0.004 0.000 0.000 0.018 0.005 0.001 0.000 0.000

psi3 0.007 0.000 0.091 0.104 0.008 0.000 0.000 0.000 0.000

psi4 0.034 0.407 7.128 1.677 -0.799 0.000 0.001 0.000 0.000

psi5 0.000 0.528 0.722 0.058 0.000 0.000 0.032 0.001 0.001

psi6 0.003 0.036 0.033 0.000 0.000 0.127 0.011 0.000 0.000

psi7 0.001 0.003 0.002 0.000 0.000 0.004 0.000 0.000 0.000

psi8 0.000 0.002 0.023 0.004 0.000 0.001 0.000 0.000 0.000

psi9 0.001 0.003 0.041 0.020 0.000 0.000 0.001 0.000 0.000

TrpSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.096 0.045 0.030 0.000 0.000 0.000 0.001 0.018 0.034

psi2 0.002 0.008 0.000 -0.269 0.000 0.000 0.001 0.001 0.002

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.027 0.026 -0.022 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.045 0.004 0.019 0.000 0.000 0.020 0.000 0.000

psi6 0.019 0.003 0.013 0.000 0.000 0.005 0.000 0.000 0.000

psi7 0.003 -0.168 0.079 0.000 0.000 0.001 0.000 0.000 0.000

psi8 -0.488 -0.367 -0.196 0.028 0.000 0.000 0.000 0.000 0.000

psi9 -1.534 -1.653 -0.301 0.029 0.000 0.000 0.000 0.006 0.016

TrpSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.141 -0.693 0.074 0.000 0.000 0.000 0.012 0.020 0.083

psi2 0.030 0.000 0.000 0.000 0.000 0.000 0.003 0.000 0.000

psi3 0.000 0.000 0.005 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.149 0.631 0.014 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.058 0.015 0.000 0.000 0.000 0.001 0.000 0.000

psi6 0.000 0.025 0.020 0.000 0.000 0.015 0.002 0.000 0.000

psi7 0.066 0.104 0.103 0.000 0.000 0.000 0.000 0.000 0.055

psi8 0.373 -1.253 -3.180 0.056 0.001 0.000 0.000 0.000 0.064

psi9 -1.722 -4.684 0.573 0.042 0.000 0.000 0.032 0.010 0.028

TrpSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.037 0.025 0.004 0.000 0.000 0.000 0.002 0.000 0.000

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.005 0.090 0.002 0.000 0.000 0.001 0.000 0.000

psi5 0.018 0.007 -0.003 0.000 0.000 0.000 0.004 0.000 0.000

psi6 0.001 0.010 0.000 0.000 0.000 0.009 0.009 0.000 0.000

psi7 0.019 0.016 -0.057 0.000 0.000 0.000 0.000 0.000 0.018

psi8 0.173 0.697 0.297 0.037 0.000 0.000 0.000 0.000 0.018

psi9 -0.021 1.020 0.183 0.098 0.000 0.000 0.000 0.000 0.000

TrpLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.026 0.097 0.360 0.005 0.000 0.010 0.029 0.015 0.008

psi2 0.003 0.026 0.002 0.001 0.018 0.014 0.009 0.001 0.001

psi3 0.001 0.042 0.036 0.006 0.000 0.000 0.001 0.019 0.000

psi4 0.001 0.064 0.092 0.212 0.000 0.000 0.020 0.013 0.001

psi5 0.017 -0.419 0.118 0.021 0.000 0.001 0.461 0.031 0.001

psi6 0.022 0.075 0.106 0.008 0.000 0.093 -0.867 0.002 0.000

psi7 -0.012 -0.390 -0.319 0.016 0.000 0.009 0.048 0.001 0.000

psi8 0.283 0.026 0.490 -0.858 0.000 0.003 0.005 0.002 0.019

psi9 -1.740 -0.161 0.849 0.210 0.000 0.000 0.030 0.014 0.055

TrpLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.109 0.096 0.180 0.008 0.000 0.011 0.061 0.044 0.051

psi2 0.003 0.023 0.053 0.007 0.000 0.032 0.015 0.002 0.007

psi3 0.025 0.020 0.044 -0.213 0.022 0.002 0.016 0.000 0.018

psi4 0.015 -0.055 0.540 -0.950 0.008 0.000 0.037 0.048 0.008

psi5 0.025 -0.481 0.290 0.275 0.000 0.014 -0.055 0.062 0.008

psi6 -0.395 0.245 0.187 0.000 0.000 0.553 0.065 0.002 0.000

psi7 0.012 0.188 0.754 0.026 0.009 0.009 0.019 0.015 0.013

psi8 -0.581 -0.088 -0.009 0.390 0.009 0.000 0.033 0.006 0.041

psi9 0.741 0.409 1.647 0.251 0.008 0.008 0.066 0.026 0.040

TrpLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.023 0.060 0.064 0.000 0.011 0.344 0.024 0.002 0.017

psi2 0.022 0.023 0.012 0.008 0.001 0.065 0.040 0.005 0.019

psi3 0.025 0.050 0.220 0.468 0.007 0.009 0.280 0.019 0.001

psi4 0.045 0.121 0.932 0.763 0.008 0.019 0.103 0.114 0.012

psi5 0.036 -0.335 0.328 0.072 0.001 0.055 0.633 0.113 0.004

psi6 0.105 0.297 0.187 0.045 0.003 -0.331 0.370 0.002 0.010

psi7 0.040 -0.581 0.283 0.060 0.019 0.048 0.057 0.002 0.000

psi8 0.066 0.309 0.603 0.499 0.008 0.004 0.026 0.000 0.036

psi9 -0.148 0.340 0.534 0.182 0.000 0.000 0.006 0.003 0.019

ValHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.009 0.005 0.005 0.000 0.000 0.004 0.023 0.001 0.000

psi2 0.002 0.001 0.030 0.000 0.000 0.010 0.006 0.000 0.000

psi3 0.004 -0.434 0.395 -0.672 0.025 0.000 0.000 0.000 0.000

psi4 0.027 0.018 -5.935 -0.581 0.000 0.000 0.000 0.003 0.000

psi5 0.029 -0.657 2.262 -0.859 0.000 0.000 0.011 0.139 0.000

psi6 0.082 0.121 0.136 0.018 0.000 0.015 0.013 0.000 0.000

psi7 0.012 -0.013 -0.114 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.028 -1.216 0.004 0.071 0.000 0.000 0.002 0.007 0.001

psi9 1.020 0.058 0.771 -0.042 0.000 0.000 0.007 0.005 0.002

ValHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.467 0.023 0.519 0.000 0.000 0.002 0.018 0.019 0.000

psi2 0.000 0.001 0.003 0.000 0.000 0.512 0.003 0.000 0.000

psi3 0.003 0.516 -2.939 0.973 0.001 0.000 0.000 0.000 0.000

psi4 0.000 0.526 -4.751 3.108 0.059 0.000 0.002 0.001 0.017

psi5 0.002 0.002 -2.275 -3.681 0.000 0.092 0.087 0.006 0.000

psi6 0.003 -0.023 0.618 0.000 0.000 0.128 0.025 0.000 0.000

psi7 0.064 -0.628 -0.066 0.026 0.000 0.026 0.001 0.000 0.000

psi8 0.273 -0.834 -0.484 0.412 0.000 0.000 0.001 0.001 0.000

psi9 0.307 0.986 1.074 0.053 0.000 0.000 0.456 0.020 0.262

ValHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.002 0.012 0.000 0.000 0.001 0.003 0.000 0.000

psi2 0.000 0.020 0.000 0.000 0.078 0.024 0.006 0.000 0.000

psi3 0.024 0.008 1.804 -0.226 0.550 0.001 0.001 0.000 0.002

psi4 0.126 1.275 3.704 3.500 0.079 0.000 0.003 0.000 0.000

psi5 0.002 -1.713 5.943 0.708 0.000 0.002 0.114 0.002 0.002

psi6 0.019 1.065 0.109 0.000 0.000 0.080 0.474 0.001 0.000

psi7 0.009 0.016 0.477 0.000 0.000 0.019 0.000 0.000 0.000

psi8 0.000 0.294 0.172 0.015 0.000 0.002 0.031 0.000 0.000

psi9 0.101 0.102 0.410 0.067 0.000 0.000 0.002 0.000 0.000

ValSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.446 0.155 0.115 0.000 0.000 0.000 0.005 0.023 0.210

psi2 0.004 0.023 0.000 0.022 0.000 0.001 0.002 0.003 0.010

psi3 0.000 0.001 0.002 0.001 0.000 0.000 0.001 0.000 0.000

psi4 0.000 -0.428 0.018 0.005 0.000 0.000 0.000 0.000 0.000

psi5 0.001 -2.020 0.014 -0.739 0.000 0.000 0.089 0.000 0.000

psi6 0.079 0.009 0.013 0.002 0.000 0.015 0.001 0.000 0.000

psi7 0.263 0.579 -0.333 0.000 0.000 0.003 0.000 0.000 0.000

psi8 -1.714 -12.119 -2.778 0.272 0.000 0.000 0.000 0.000 0.003

psi9 -1.646 -6.106 1.296 -0.217 0.000 0.000 0.001 0.017 0.065

ValSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.722 -1.338 0.054 0.000 0.000 0.000 0.024 0.035 0.281

psi2 0.128 0.000 0.000 0.000 0.000 0.000 0.021 0.000 0.000

psi3 0.000 0.001 0.030 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.322 0.000 0.040 0.000 0.000 0.000 0.000 0.000

psi5 0.000 -1.801 -0.031 0.001 0.000 0.000 0.004 0.099 0.000

psi6 0.001 0.092 0.095 0.000 0.000 0.013 0.017 0.000 0.000

psi7 -0.742 -0.912 -0.167 0.000 0.000 0.001 0.000 0.000 0.234

psi8 -3.127 -7.685 -6.135 -0.285 0.002 0.000 0.000 0.000 -0.544

psi9 1.346 -5.597 1.135 0.179 0.000 0.000 0.087 0.044 0.125

ValSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.157 0.125 0.011 0.000 0.000 0.000 0.005 0.000 0.001

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.080 0.113 0.008 0.000 0.000 0.003 0.000 0.000

psi5 0.078 -0.116 0.043 0.000 0.000 0.000 0.011 0.000 0.000

psi6 0.003 0.013 0.000 0.000 0.000 0.549 0.012 0.000 0.000

psi7 0.081 0.087 0.119 0.000 0.000 0.000 0.000 0.000 0.078

psi8 0.712 -2.905 0.769 0.150 0.000 0.000 0.000 0.000 -0.739

psi9 -1.114 -0.037 0.220 0.382 0.000 0.000 0.000 0.000 0.001

ValLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.105 0.211 0.334 0.023 0.000 0.034 0.086 0.046 0.030

psi2 0.010 0.106 0.008 0.004 0.078 0.155 0.819 0.003 0.002

psi3 0.003 -0.306 -0.153 0.034 0.000 0.000 0.003 0.079 0.001

psi4 0.010 -0.483 -4.133 0.185 0.000 0.002 0.061 0.144 0.004

psi5 0.011 0.809 0.464 -0.140 0.000 0.004 0.359 0.126 0.001

psi6 0.089 0.436 0.235 0.023 0.000 0.248 0.132 0.006 0.000

psi7 0.129 0.917 -0.768 0.047 0.002 0.035 0.034 0.002 0.000

psi8 -0.062 -5.201 -5.587 0.413 0.000 0.028 -0.211 0.008 0.083

psi9 1.332 -1.153 2.683 0.040 0.000 0.000 -0.094 0.055 0.203

ValLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.381 -0.034 0.723 0.025 0.000 0.032 0.209 0.167 0.178

psi2 0.027 0.091 0.192 0.236 0.003 0.124 0.061 0.009 0.023

psi3 -0.032 0.083 0.009 0.239 0.106 0.033 0.101 0.000 0.078

psi4 0.067 -1.012 -0.225 -0.221 0.023 0.000 0.359 0.134 0.034

psi5 0.293 1.195 1.854 0.242 0.001 0.039 1.824 0.280 0.024

psi6 0.166 0.880 0.297 0.001 0.002 -2.195 1.436 0.022 0.001

psi7 0.731 0.555 0.825 0.088 0.025 0.234 0.123 0.046 0.053

psi8 -0.866 -1.018 -0.026 0.755 0.027 0.000 0.021 0.063 0.241

psi9 0.247 -2.333 7.222 1.742 0.026 0.023 0.176 0.079 0.360

ValLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.116 1.739 0.221 0.001 0.023 0.193 0.383 0.005 -0.223

psi2 0.059 -0.033 0.040 0.024 0.008 0.402 0.494 0.038 0.079

psi3 0.114 -0.402 0.177 0.436 0.024 0.028 0.207 -0.010 0.003

psi4 -0.107 0.525 -0.191 4.000 0.029 0.080 0.667 0.146 0.037

psi5 0.189 0.401 4.501 0.335 0.006 0.216 2.588 0.491 0.038

psi6 0.474 -0.285 0.992 0.155 0.008 2.659 1.091 0.006 0.051

psi7 0.172 -1.015 1.179 0.176 0.063 0.236 0.233 0.019 0.001

psi8 0.006 -1.905 0.259 -1.775 0.052 0.027 0.012 0.003 0.141

psi9 0.390 0.851 1.692 0.362 0.000 0.000 0.024 0.094 0.082

IleHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.017 0.004 0.005 0.000 0.000 0.004 0.143 0.001 0.000

psi2 0.002 0.001 0.024 0.000 0.000 0.009 0.004 0.000 0.000

psi3 0.002 -0.162 -0.671 0.001 0.069 0.000 0.000 0.000 0.000

psi4 0.019 -2.687 -4.545 -7.534 0.000 0.000 0.000 0.078 0.000

psi5 0.029 -0.379 -0.788 -0.984 0.000 0.000 0.010 0.005 0.000

psi6 0.184 -0.014 0.102 0.014 0.000 0.013 0.012 0.000 0.000

psi7 -0.003 0.006 -0.196 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.014 -0.368 -0.389 -0.169 0.000 0.000 0.001 0.016 0.000

psi9 0.020 0.197 0.161 0.008 0.000 0.000 0.006 0.004 0.002

IleHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.018 -0.008 0.032 0.000 0.000 0.001 0.034 0.018 0.000

psi2 0.000 0.001 0.003 0.000 0.000 0.115 0.002 0.000 0.000

psi3 0.002 0.004 -0.673 1.518 0.001 0.000 0.000 0.000 0.000

psi4 0.000 -0.147 -0.572 -0.763 -0.413 0.000 0.001 0.001 0.014

psi5 0.002 1.115 1.289 -3.041 0.000 0.003 0.065 0.260 0.000

psi6 0.002 0.582 0.653 0.000 0.000 0.091 0.442 0.000 0.000

psi7 0.305 0.070 0.237 0.019 0.000 0.026 0.000 0.000 0.000

psi8 0.224 -0.331 -0.250 0.147 0.000 0.000 0.001 0.001 0.000

psi9 0.202 0.416 1.142 0.040 0.000 0.000 0.056 0.007 0.001

IleHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.009 0.000 0.000 0.001 0.003 0.000 0.000

psi2 0.000 0.014 0.000 0.000 0.046 0.009 0.006 0.000 0.000

psi3 0.026 0.018 1.021 -1.109 0.129 0.001 0.001 0.000 0.001

psi4 0.078 0.548 1.862 -0.846 0.046 0.000 0.002 0.000 0.000

psi5 0.001 1.926 -1.277 0.647 0.000 0.002 0.097 0.002 0.002

psi6 0.010 0.068 0.074 0.000 0.000 0.089 0.041 0.001 0.000

psi7 0.003 0.023 0.008 0.000 0.000 0.016 0.000 0.000 0.000

psi8 0.085 0.008 0.098 0.012 0.000 0.002 0.000 0.000 0.000

psi9 0.003 0.007 0.357 0.044 0.000 0.000 0.002 0.000 0.000

IleSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.413 -0.183 0.069 0.000 0.000 0.000 0.004 0.029 0.112

psi2 0.005 0.013 0.000 0.012 0.000 0.001 0.002 0.003 0.005

psi3 0.000 0.001 0.002 0.001 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.053 -0.023 0.004 0.000 0.000 0.000 0.000 0.000

psi5 0.001 -0.438 -0.014 0.046 0.000 0.000 0.054 0.000 0.000

psi6 0.047 0.004 0.006 0.001 0.000 0.009 0.001 0.000 0.000

psi7 0.010 -0.718 -0.267 0.000 0.000 0.002 0.000 0.000 0.000

psi8 -1.211 -6.707 -7.445 -0.186 0.000 0.000 0.000 0.000 0.002

psi9 -2.301 -0.447 0.827 0.046 0.000 0.000 0.001 0.009 0.043

IleSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.407 -0.323 0.146 0.000 0.000 0.000 0.013 0.033 0.407

psi2 0.080 0.000 0.000 0.000 0.000 0.000 0.010 0.000 0.000

psi3 0.000 0.001 0.023 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.046 0.125 0.037 0.000 0.000 0.000 0.000 0.000

psi5 0.000 -0.200 0.191 0.001 0.000 0.000 0.003 0.000 0.000

psi6 0.000 -0.763 0.345 0.000 0.000 0.020 0.008 0.000 0.000

psi7 0.176 0.614 -1.375 0.000 0.000 0.000 0.000 0.000 0.138

psi8 1.309 -5.730 -2.521 -0.052 -0.088 0.000 0.000 0.000 0.165

psi9 3.337 -0.325 1.172 0.117 0.000 0.000 0.063 0.031 0.076

IleSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.093 0.079 0.006 0.000 0.000 0.000 0.005 0.000 0.011

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.366 0.055 0.005 0.000 0.000 0.002 0.000 0.000

psi5 0.046 0.015 0.037 0.000 0.000 0.000 0.011 0.000 0.000

psi6 0.003 0.007 0.000 0.000 0.000 0.024 0.011 0.000 0.000

psi7 0.049 -0.014 -0.070 0.000 0.000 0.000 0.000 0.000 0.046

psi8 0.425 -0.814 -2.279 0.060 0.000 0.000 0.000 0.000 0.046

psi9 0.993 0.555 0.431 0.241 0.000 0.000 0.000 0.000 0.001

IleLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.168 0.183 0.010 0.021 0.614 0.022 0.063 0.027 0.023

psi2 -0.081 0.069 0.006 0.003 0.046 0.030 -0.038 0.002 0.002

psi3 0.003 0.099 -0.083 0.029 0.000 0.000 0.003 0.047 0.000

psi4 0.004 -3.167 0.117 0.206 0.000 0.001 -0.145 0.045 0.004

psi5 0.092 0.952 -0.584 -0.242 0.000 0.003 0.261 0.114 0.001

psi6 0.054 0.290 0.072 0.013 0.000 0.197 0.262 0.006 0.000

psi7 0.097 -2.423 -0.115 0.026 0.001 0.030 0.006 0.002 0.000

psi8 0.330 -6.404 -4.294 0.483 0.000 0.021 -0.059 0.007 0.050

psi9 0.297 -3.842 1.989 0.232 0.000 0.000 0.067 0.032 0.121

IleLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.243 0.535 1.112 0.008 0.000 0.021 0.735 0.117 0.255

psi2 0.015 -0.024 0.429 0.007 0.002 0.077 0.043 0.004 0.006

psi3 -0.757 -0.123 0.021 0.157 0.060 -0.229 0.079 0.000 0.046

psi4 -0.046 -0.307 1.654 0.711 0.013 0.000 0.561 0.075 0.033

psi5 -0.002 -1.359 1.667 -1.785 0.001 0.022 2.463 0.550 0.014

psi6 0.094 0.594 0.579 0.001 0.001 0.521 0.347 0.018 0.001

psi7 0.275 1.530 0.922 -0.124 0.014 0.191 0.104 0.018 0.034

psi8 0.625 -3.548 -1.651 0.241 0.016 0.000 0.182 0.018 0.082

psi9 2.108 -2.421 7.556 1.351 0.009 0.012 0.680 0.230 -0.765

IleLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.029 0.222 0.189 0.001 0.067 0.120 0.055 0.005 0.029

psi2 0.104 0.097 0.032 0.013 0.007 0.341 0.125 0.029 0.047

psi3 0.088 0.089 -0.363 0.267 0.007 0.016 -0.145 0.021 0.003

psi4 0.149 -0.650 3.581 0.130 0.022 0.047 0.331 0.166 0.025

psi5 0.138 -0.820 2.900 0.188 0.002 0.146 3.634 0.210 0.023

psi6 0.450 1.962 0.729 0.103 0.011 1.926 1.554 0.005 -0.037

psi7 0.149 0.594 2.162 0.205 0.087 0.189 0.142 0.016 0.001

psi8 0.336 -1.222 -1.001 1.973 0.042 0.027 -0.763 0.002 0.108

psi9 1.034 -0.074 1.493 0.628 0.000 0.000 0.025 0.015 0.049

MetHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.006 0.001 0.001 0.178 0.000 0.001 0.007 0.000 0.000

psi2 0.001 0.000 0.012 0.000 0.000 0.003 0.002 0.000 0.000

psi3 0.001 0.015 0.438 0.041 0.012 0.000 0.000 0.000 0.000

psi4 0.010 -0.105 -2.112 0.439 0.000 0.000 0.000 0.001 0.000

psi5 0.010 -0.732 -0.593 0.066 0.000 0.000 0.003 0.002 0.000

psi6 0.036 -0.189 0.032 0.006 0.000 0.005 0.004 0.000 0.000

psi7 0.007 0.026 0.026 0.000 0.000 0.000 0.000 0.000 0.000

psi8 0.008 -0.125 -0.012 0.371 0.000 0.000 0.001 0.005 0.000

psi9 0.007 0.378 0.064 0.002 0.000 0.000 0.003 0.002 0.001

Methm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.006 0.010 0.010 0.000 0.000 0.000 0.007 0.009 0.000

psi2 0.000 0.000 0.001 0.000 0.000 0.006 0.005 0.000 0.000

psi3 0.348 0.001 0.771 0.980 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.251 -7.994 0.636 0.006 0.000 0.000 0.000 0.006

psi5 0.000 0.462 -1.389 -0.401 0.000 0.002 0.020 0.002 0.000

psi6 0.001 0.027 0.231 0.000 0.000 0.028 0.006 0.000 0.000

psi7 0.057 0.498 0.031 0.007 0.000 0.010 0.000 0.000 0.000

psi8 0.111 0.154 -0.196 -1.863 0.000 0.000 0.000 0.000 0.000

psi9 0.118 -0.151 0.254 0.017 0.000 0.000 0.014 0.004 0.000

Methe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.000 0.002 0.000 0.000 0.000 0.001 0.000 0.000

psi2 0.000 0.006 0.000 0.000 0.012 0.007 0.002 0.000 0.000

psi3 -0.184 0.010 0.335 1.018 0.040 0.001 0.000 0.000 0.000

psi4 0.012 0.791 4.474 -4.188 0.012 0.000 0.001 0.000 0.000

psi5 0.000 0.309 2.864 0.166 0.000 0.001 0.035 0.001 0.001

psi6 0.001 0.139 0.052 0.000 0.000 0.021 0.013 0.000 0.000

psi7 0.001 0.002 0.004 0.000 0.000 0.009 0.000 0.000 0.000

psi8 0.000 0.004 0.032 -0.506 0.000 0.001 0.000 0.000 0.000

psi9 0.001 0.002 0.241 0.017 0.000 0.000 0.000 0.000 0.000

Metsb

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.076 0.032 0.020 0.000 0.000 0.000 0.001 0.009 0.048

psi2 0.002 0.005 0.000 0.005 0.000 0.000 0.001 0.001 0.002

psi3 0.000 0.000 0.001 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.133 -0.360 0.001 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.029 -0.014 0.012 0.000 0.000 0.012 0.000 0.000

psi6 0.012 -0.021 0.003 0.001 0.000 0.005 0.000 0.000 0.000

psi7 0.003 -0.072 0.093 0.000 0.000 0.001 0.000 0.000 0.000

psi8 -0.796 1.622 -2.022 -0.130 0.000 0.000 0.000 0.000 0.001

psi9 -0.246 0.711 -0.084 0.015 0.000 0.000 0.000 0.001 0.381

MetSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.460 -0.008 0.048 0.000 0.000 0.000 0.006 0.013 0.096

psi2 0.028 0.000 0.000 0.000 0.000 0.000 0.003 0.000 0.000

psi3 0.000 0.000 0.009 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.002 -0.307 0.002 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.058 0.008 0.000 0.000 0.000 0.001 0.000 0.000

psi6 0.000 0.013 0.014 0.000 0.000 0.007 0.002 0.000 0.000

psi7 0.048 0.280 0.041 0.000 0.000 0.000 0.000 0.000 0.034

psi8 0.300 -2.635 -2.808 0.035 0.001 0.000 0.000 0.000 0.045

psi9 1.074 0.933 -0.581 0.032 0.000 0.000 0.017 0.012 -0.018

MetSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.023 0.018 0.004 0.000 0.000 0.000 0.001 0.000 0.000

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.004 0.020 0.002 0.000 0.000 0.001 0.000 0.000

psi5 0.011 0.000 0.013 0.000 0.000 0.000 0.012 0.000 0.000

psi6 0.001 0.003 0.000 0.000 0.000 0.006 0.001 0.000 0.000

psi7 0.012 0.012 0.046 0.000 0.000 0.000 0.000 0.000 0.011

psi8 0.136 0.612 0.774 0.032 0.000 0.000 0.000 0.000 0.012

psi9 0.049 0.541 0.099 0.072 0.000 0.000 0.000 0.000 0.000

MetLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.162 -0.191 0.160 0.010 0.000 0.009 0.021 0.011 0.008

psi2 0.003 0.023 0.002 0.001 0.012 0.011 0.009 0.001 0.001

psi3 0.001 0.042 0.044 0.012 0.000 0.000 0.001 0.012 0.000

psi4 0.002 0.368 -0.258 -0.525 0.000 0.001 0.015 0.018 0.001

psi5 0.021 0.149 -0.174 0.014 0.000 0.001 0.220 0.050 0.000

psi6 0.012 -1.624 -0.547 0.005 0.000 0.046 0.012 0.002 0.000

psi7 0.521 0.263 -0.027 0.011 0.001 0.012 0.002 0.001 0.000

psi8 -0.429 -0.283 1.130 -0.732 0.000 0.008 0.021 0.002 0.013

psi9 -0.014 0.036 -3.451 0.112 0.000 0.000 0.024 0.010 0.043

Metlm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.079 0.079 0.239 0.004 0.000 0.008 0.093 0.045 0.061

psi2 0.015 0.028 0.038 0.003 0.001 0.022 0.021 0.002 0.003

psi3 0.019 -0.058 0.057 0.081 0.025 0.011 0.061 0.000 0.012

psi4 -0.072 0.020 0.616 -0.731 0.005 0.000 0.062 0.372 0.013

psi5 0.070 0.794 1.646 0.104 0.000 0.008 0.695 0.068 0.006

psi6 -0.159 0.192 -0.983 0.000 0.001 -0.044 -0.552 0.007 0.000

psi7 -0.070 -0.838 0.455 0.023 0.006 0.046 0.040 0.008 0.015

psi8 -0.479 -0.071 -0.195 1.261 0.007 0.000 0.072 0.007 0.031

psi9 1.677 0.434 1.996 -0.092 0.003 0.005 0.082 0.062 0.027

Metle

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.014 0.077 0.059 0.000 -2.895 0.428 0.123 0.002 0.012

psi2 -1.103 0.012 0.014 -0.271 0.002 0.080 0.047 0.010 0.012

psi3 0.029 0.086 0.100 -0.076 0.003 0.007 0.145 0.007 0.001

psi4 0.036 0.063 1.513 0.429 0.011 0.012 0.084 0.124 0.011

psi5 0.074 1.150 -0.890 -0.425 0.001 0.069 0.798 0.070 0.018

psi6 0.160 0.235 -0.025 0.042 0.001 0.546 0.930 0.002 0.010

psi7 0.038 0.162 -0.261 0.061 0.019 0.231 0.040 0.006 0.000

psi8 0.091 0.501 2.522 -0.895 0.015 0.008 0.040 0.001 0.031

psi9 0.391 -5.029 0.330 0.280 0.000 0.000 0.007 0.003 0.013

HisHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.012 0.002 0.002 0.000 0.000 0.001 0.017 0.000 0.000

psi2 0.001 0.000 0.010 0.000 0.000 0.004 0.001 0.000 0.000

psi3 0.001 0.012 0.150 0.453 0.023 0.000 0.000 0.000 0.000

psi4 0.006 0.084 7.027 4.715 0.000 0.000 0.000 0.001 0.000

psi5 0.006 0.238 0.160 -0.279 0.000 0.000 0.004 0.004 0.000

psi6 0.214 0.055 0.120 0.002 0.000 0.005 0.005 0.000 0.000

psi7 0.013 0.026 0.023 0.000 0.000 0.000 0.000 0.000 0.000

psi8 0.010 0.151 0.027 0.306 0.000 0.000 0.001 0.012 0.000

psi9 0.010 0.009 -0.443 0.002 0.000 0.000 0.002 0.002 0.000

HisHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.300 0.006 0.019 0.000 0.000 0.001 0.017 0.003 0.000

psi2 0.000 0.000 0.001 0.000 0.000 0.010 0.017 0.000 0.000

psi3 0.001 0.002 0.334 1.659 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.200 -2.289 1.546 0.037 0.000 0.001 0.000 0.007

psi5 -0.018 -3.983 -0.121 0.592 0.000 0.003 0.026 0.002 0.000

psi6 0.001 -0.986 -0.045 0.000 0.000 -0.121 0.009 0.000 0.000

psi7 0.020 -0.789 0.029 0.008 0.000 0.006 0.000 0.000 0.000

psi8 -0.646 0.036 -1.172 -0.013 0.000 0.000 0.001 0.000 0.000

psi9 -0.977 0.713 -0.993 0.403 0.000 0.000 0.030 0.007 0.000

HisHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.002 0.000 0.000 0.000 0.001 0.000 0.000

psi2 0.000 0.004 0.000 0.000 0.018 -0.104 0.002 0.000 0.000

psi3 0.004 0.007 -2.176 0.526 0.040 0.001 0.000 0.000 0.000

psi4 0.081 -1.690 1.424 -5.795 0.019 0.000 0.001 0.000 0.000

psi5 0.000 -2.458 -3.989 0.327 0.000 0.001 0.037 0.001 0.001

psi6 0.001 -1.396 0.238 0.000 0.000 0.032 0.014 0.000 0.000

psi7 0.003 -0.629 0.005 0.000 0.000 0.003 0.000 0.000 0.000

psi8 0.000 0.007 0.029 0.006 0.000 0.001 0.000 0.000 0.000

psi9 -0.339 0.132 -3.045 0.016 0.000 0.000 0.001 0.000 0.000

HisSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.124 0.053 0.030 0.000 0.000 0.000 0.002 0.016 0.301

psi2 0.002 0.008 0.000 0.008 0.000 0.000 0.001 0.001 0.003

psi3 0.000 0.001 0.001 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.467 0.087 0.002 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.049 0.005 0.019 0.000 0.000 0.022 0.000 0.000

psi6 0.019 0.003 0.005 0.000 0.000 0.005 0.000 0.000 0.000

psi7 0.004 0.361 -0.729 0.000 0.000 0.000 0.000 0.000 0.000

psi8 1.209 3.957 0.534 0.027 0.000 0.000 0.000 0.000 0.001

psi9 0.010 1.488 1.612 0.036 0.000 0.000 0.000 0.013 0.017

HisSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.328 0.124 0.044 0.000 0.000 0.000 0.008 0.021 0.033

psi2 0.019 0.000 0.000 0.000 0.000 0.000 0.002 0.000 0.000

psi3 0.000 0.001 0.008 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.460 -0.244 0.007 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.090 0.009 0.000 0.000 0.000 0.001 0.000 0.000

psi6 0.000 0.022 0.021 0.000 0.000 -0.076 0.002 0.000 0.000

psi7 -0.751 0.096 0.238 0.000 0.000 0.000 0.000 0.000 0.055

psi8 -1.569 -2.518 1.256 0.046 0.000 0.000 0.000 0.000 0.070

psi9 -2.107 -0.046 -0.777 0.047 0.000 0.000 0.030 0.016 -0.643

HisSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.037 0.033 0.004 0.000 0.000 0.000 0.001 0.000 0.000

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.003 0.072 0.001 0.000 0.000 0.001 0.000 0.000

psi5 0.018 -0.004 0.014 0.000 0.000 0.000 0.001 0.000 0.000

psi6 0.001 0.003 0.000 0.000 0.000 0.008 0.006 0.000 0.000

psi7 0.020 0.015 0.032 0.000 0.000 0.000 0.000 0.000 0.018

psi8 0.353 0.381 0.385 0.049 0.000 0.000 0.000 0.000 0.018

psi9 0.116 -0.307 0.132 0.091 0.000 0.000 0.000 0.000 0.000

HisLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.022 0.009 0.138 0.004 0.000 0.011 0.162 0.014 0.017

psi2 0.002 -0.244 0.006 0.001 0.018 0.014 0.010 0.001 0.001

psi3 0.001 0.019 0.040 0.011 0.000 0.000 0.001 0.019 0.000

psi4 0.004 0.041 1.831 0.718 0.000 0.000 -0.004 0.013 0.002

psi5 0.015 0.257 -0.216 0.020 0.000 0.001 0.420 0.081 0.001

psi6 -0.068 0.139 -0.328 0.008 0.000 -0.178 0.063 0.002 0.000

psi7 0.036 0.066 1.053 0.016 0.000 0.011 0.002 0.001 0.000

psi8 0.518 0.525 1.640 0.500 0.000 0.005 0.011 0.003 0.020

psi9 0.014 0.221 0.430 0.084 0.000 0.000 0.221 0.022 -0.214

HisLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.405 -0.191 0.600 0.007 0.000 0.011 0.217 0.060 0.055

psi2 0.003 0.052 0.053 0.006 0.001 0.033 0.017 0.004 0.006

psi3 0.027 0.032 0.052 0.095 0.021 0.013 0.025 0.000 0.019

psi4 0.024 0.224 0.499 0.865 0.008 0.000 -0.078 0.018 0.014

psi5 0.002 -0.291 -0.330 0.096 0.000 0.013 1.081 0.679 0.009

psi6 0.105 -2.913 0.032 0.000 0.000 0.443 0.050 0.008 0.000

psi7 -0.140 -0.171 -0.274 0.024 0.009 0.071 -0.055 0.014 0.013

psi8 -0.119 -0.105 0.779 -0.051 0.009 0.000 0.249 0.007 -1.268

psi9 -0.973 -1.446 1.159 1.267 0.007 0.008 0.541 0.060 0.103

Hisle

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.111 -3.081 0.080 0.000 0.022 0.011 0.030 0.002 0.058

psi2 0.030 0.021 0.009 0.008 -0.091 0.358 0.032 0.006 0.019

psi3 0.129 0.087 0.079 0.151 0.007 0.009 0.045 0.015 0.001

psi4 0.054 0.155 -0.932 0.911 0.010 0.019 0.152 0.051 0.013

psi5 0.046 0.712 2.577 0.403 0.003 0.037 1.428 0.068 0.007

psi6 0.220 -1.988 0.319 0.022 0.001 -1.593 -1.428 0.002 0.011

psi7 -1.357 -2.056 -0.261 0.097 0.035 0.062 0.057 0.007 0.000

psi8 0.199 -0.714 -1.280 0.726 0.011 0.008 0.009 0.001 0.034

psi9 -0.076 -0.921 2.861 0.338 0.000 0.000 0.007 0.003 0.020

TyrHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.025 0.003 0.003 0.000 0.000 0.002 0.030 0.000 0.000

psi2 0.002 0.000 0.009 0.000 0.000 0.005 0.002 0.000 0.000

psi3 0.002 -0.085 -0.060 0.213 0.012 0.000 0.000 0.000 0.000

psi4 0.006 -1.483 0.488 0.239 0.000 0.000 0.000 0.001 0.000

psi5 0.014 -0.337 0.010 0.109 0.000 0.000 0.006 0.005 0.000

psi6 0.074 0.045 0.048 0.004 0.000 0.008 0.006 0.000 0.000

psi7 0.027 -0.271 0.035 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.016 0.054 0.460 0.027 0.000 0.000 0.001 0.024 0.000

psi9 0.014 0.011 0.193 0.094 0.000 0.000 0.004 0.003 0.001

TyrHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.026 0.086 0.044 0.000 0.000 0.001 0.030 0.008 0.000

psi2 0.000 0.000 0.002 0.000 0.000 0.011 0.018 0.000 0.000

psi3 0.001 0.088 1.153 -1.351 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.327 -2.214 -2.690 0.033 0.000 0.001 0.000 0.010

psi5 0.001 -1.900 -1.099 0.220 0.000 0.002 0.012 0.003 0.000

psi6 0.002 0.055 0.459 0.000 0.000 0.049 -0.023 0.000 0.000

psi7 0.032 -0.663 0.046 0.007 0.000 0.009 0.000 0.000 0.000

psi8 -0.081 0.056 -0.582 -0.971 0.000 0.000 0.001 0.001 0.000

psi9 0.184 0.253 0.492 0.022 0.000 0.000 0.057 0.009 0.001

Tyrhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.013 0.000 0.000 0.000 0.002 0.000 0.000

psi2 0.000 0.006 0.000 0.000 0.023 0.010 0.004 0.000 0.000

psi3 0.011 0.007 0.158 1.365 0.317 0.002 0.000 0.000 0.001

psi4 0.039 -0.036 2.155 6.829 0.023 0.000 0.001 0.000 0.000

psi5 0.001 1.065 0.961 0.220 0.000 0.001 0.084 0.001 0.001

psi6 0.003 -0.464 -0.195 0.000 0.000 0.056 0.132 0.001 0.000

psi7 0.004 0.008 0.007 0.000 0.000 0.007 0.000 0.000 0.000

psi8 0.000 0.008 0.047 0.259 0.000 0.001 0.000 0.000 0.000

psi9 0.002 0.004 0.198 0.023 0.000 0.000 0.001 0.000 0.000

TyrSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.264 0.088 0.047 0.000 0.000 0.000 0.002 0.033 0.067

psi2 0.002 0.017 0.000 0.016 0.000 0.000 0.001 0.001 0.003

psi3 0.000 0.001 0.001 0.000 0.000 0.000 0.102 0.000 0.000

psi4 0.000 0.088 0.068 0.002 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.097 0.007 0.023 0.000 0.000 0.027 0.000 0.000

psi6 0.024 0.257 0.006 0.001 0.000 -0.181 0.001 0.000 0.000

psi7 0.006 0.271 0.185 0.000 0.000 0.003 0.000 0.000 0.000

psi8 0.207 0.185 -1.674 0.044 0.000 0.000 0.000 0.000 0.001

psi9 -0.708 -3.241 1.391 -0.057 0.000 0.000 0.000 0.006 0.233

TyrSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.268 0.072 0.079 0.000 0.000 0.000 0.007 0.042 0.403

psi2 0.110 0.000 0.000 0.000 0.000 0.000 0.007 0.000 0.000

psi3 0.000 0.001 0.011 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.067 0.049 0.017 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.279 0.014 0.000 0.000 0.000 0.002 0.000 0.000

psi6 0.000 0.028 0.027 0.000 0.000 0.029 0.004 0.000 0.000

psi7 0.088 0.050 0.184 0.000 0.000 0.000 0.000 0.000 0.069

psi8 -1.143 -2.691 -1.735 0.298 0.001 0.000 0.000 0.000 0.095

psi9 -4.927 -5.679 -3.432 0.065 0.000 0.000 0.048 0.029 0.047

TyrSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.047 0.035 0.007 0.000 0.000 0.000 0.002 0.000 0.000

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi3 0.000 0.000 -0.832 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.011 0.023 0.003 0.000 0.000 0.003 0.000 0.000

psi5 0.023 0.009 0.014 0.000 0.000 0.000 0.007 0.000 0.000

psi6 0.001 0.004 0.000 0.000 0.000 0.012 0.005 0.000 0.000

psi7 0.025 0.035 0.120 0.000 0.000 0.000 0.000 0.000 0.023

psi8 -1.915 0.066 -0.628 0.053 0.000 0.000 0.000 0.000 0.023

psi9 0.831 -1.237 -0.818 0.117 0.000 0.000 0.000 0.000 0.000

TyrLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.043 -0.084 0.125 0.009 0.000 0.021 0.046 0.030 0.019

psi2 0.008 0.033 0.003 0.002 0.023 0.027 0.015 0.001 0.001

psi3 0.002 0.081 -0.005 -0.096 0.000 0.000 0.002 0.023 0.000

psi4 0.005 -0.540 -0.073 -0.021 0.000 0.001 0.092 0.028 0.002

psi5 -0.009 0.340 2.467 0.034 0.000 0.002 0.189 0.096 0.001

psi6 0.046 -0.276 0.089 0.017 0.000 -0.462 -0.581 0.003 0.000

psi7 0.073 -1.489 0.360 0.034 0.001 -0.068 0.004 0.001 0.000

psi8 0.507 0.010 0.303 0.947 0.000 0.007 0.022 0.004 0.025

psi9 -0.602 -0.413 1.553 0.232 0.000 0.000 0.062 0.027 -0.145

TyrLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.258 0.421 1.023 0.008 0.000 0.022 0.089 0.104 0.221

psi2 0.011 0.047 0.085 0.008 0.001 0.053 0.136 0.003 0.007

psi3 0.035 0.357 0.075 0.140 0.033 0.020 0.061 0.000 0.023

psi4 0.041 -0.152 0.264 -1.467 0.017 0.000 -0.613 0.061 0.019

psi5 0.053 -1.657 1.096 0.122 0.000 0.015 2.440 0.181 0.017

psi6 -0.132 -0.769 0.610 0.000 0.001 -1.303 0.629 0.012 0.000

psi7 0.476 -0.999 -1.391 0.056 0.018 0.196 0.059 0.023 0.027

psi8 -0.753 -0.408 -3.476 1.091 0.019 0.000 -0.228 0.010 0.051

psi9 0.104 -3.909 3.839 0.726 0.008 0.017 0.417 0.059 0.072

TyrLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.031 -2.155 0.120 0.000 0.011 0.199 0.357 0.003 0.036

psi2 0.043 0.041 0.017 0.017 0.005 0.156 0.138 0.008 0.023

psi3 0.068 0.124 -0.004 0.171 0.007 0.019 0.157 0.230 0.002

psi4 0.060 0.787 2.418 1.133 0.011 0.024 0.202 0.071 0.023

psi5 -0.728 1.642 2.807 0.495 0.001 -0.106 2.025 -0.427 0.018

psi6 0.242 0.571 0.374 0.056 0.003 1.239 0.533 0.004 0.013

psi7 0.077 0.360 1.458 -1.245 0.027 0.133 0.101 0.011 0.001

psi8 0.218 0.726 -1.612 1.167 0.016 0.014 -0.143 0.001 0.057

psi9 -1.015 0.409 1.623 -0.349 0.000 0.000 0.016 0.006 -0.793

AlaHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.013 0.008 0.008 0.000 0.000 0.007 0.025 0.001 0.001

psi2 0.004 0.001 0.028 0.000 0.001 0.128 0.006 0.001 0.000

psi3 0.006 0.139 -1.286 0.618 -3.071 0.000 0.000 0.000 0.000

psi4 -0.161 -0.989 -5.917 -9.038 0.000 0.000 0.000 0.004 0.000

psi5 0.038 0.487 -1.709 -2.503 0.000 0.000 0.018 0.017 0.000

psi6 0.653 0.163 -0.414 0.017 0.000 0.273 -0.080 0.000 0.000

psi7 -0.461 -1.097 0.033 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.522 0.128 0.198 0.077 0.000 0.000 0.002 0.010 0.001

psi9 0.053 -0.055 -0.632 0.232 0.000 0.000 0.011 0.006 0.002

AlaHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.015 0.088 0.047 0.000 0.000 0.002 0.815 0.023 0.000

psi2 0.000 0.001 0.006 0.000 0.000 0.042 0.036 0.000 0.000

psi3 -0.187 0.007 0.511 2.425 0.001 0.000 0.000 0.000 0.000

psi4 0.001 -1.148 -2.367 -4.585 0.108 0.000 0.002 0.001 0.019

psi5 0.003 1.362 0.346 -1.974 0.000 0.011 0.085 0.185 0.001

psi6 0.342 -0.035 0.009 0.000 0.000 0.101 0.038 0.000 0.000

psi7 -0.022 1.646 -3.795 0.023 0.000 -0.062 0.001 0.001 0.000

psi8 0.470 0.160 2.309 0.461 0.000 0.000 0.002 0.002 0.000

psi9 -0.096 -0.239 0.585 0.044 0.000 0.000 0.048 0.030 0.002

Alahe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.003 0.015 0.001 0.000 0.001 0.005 0.000 0.000

psi2 0.000 0.018 0.000 0.000 -0.760 0.087 0.008 0.000 0.000

psi3 0.030 0.012 0.570 0.749 0.743 0.002 0.001 0.000 -0.062

psi4 -2.576 2.444 -5.268 -1.666 0.058 0.000 0.004 0.001 0.000

psi5 0.083 2.052 -3.376 2.192 0.000 0.003 0.241 0.004 0.003

psi6 0.008 0.521 -0.171 0.000 0.000 -0.898 0.067 0.002 0.000

psi7 0.005 0.014 0.023 0.000 0.000 0.021 0.000 0.000 0.000

psi8 0.001 0.026 0.060 0.019 0.000 0.003 0.000 0.000 0.000

psi9 0.005 0.275 0.282 0.264 0.000 0.000 0.003 0.000 0.000

AlaSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.669 0.263 0.094 0.000 0.000 0.000 0.008 0.034 0.506

psi2 0.008 0.016 0.000 0.014 0.000 0.001 0.003 0.005 0.014

psi3 0.000 -0.508 0.003 0.001 0.000 0.000 0.002 0.000 0.000

psi4 0.000 0.207 0.481 0.008 0.000 0.000 0.000 0.000 0.000

psi5 0.001 0.126 0.020 0.058 0.000 0.000 0.065 0.000 0.000

psi6 0.060 0.013 0.012 0.002 0.000 0.018 0.002 0.000 0.000

psi7 0.017 0.226 1.003 0.001 0.000 0.005 0.000 0.000 0.000

psi8 -0.399 0.668 0.300 0.119 0.000 0.000 0.000 0.000 0.003

psi9 -3.747 -0.874 2.968 0.050 0.000 0.000 0.001 0.014 -0.181

AlaSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -1.074 0.054 0.800 0.000 0.000 0.000 0.094 0.045 0.262

psi2 0.108 0.001 0.000 0.000 0.000 0.000 0.026 0.000 0.000

psi3 0.000 0.002 0.028 0.001 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.617 -0.663 0.050 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.213 -1.006 0.001 0.000 0.000 0.006 0.000 0.000

psi6 0.001 0.070 0.078 0.000 0.000 0.021 0.022 0.000 0.000

psi7 0.221 0.008 0.394 0.000 0.000 0.001 0.001 0.000 0.173

psi8 -1.211 5.205 4.022 0.241 0.003 0.000 0.000 0.001 0.207

psi9 -1.626 3.230 2.667 0.155 0.000 0.000 0.070 0.042 0.110

AlaSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.117 0.090 0.012 0.000 0.000 0.000 -1.326 0.000 0.001

psi2 0.001 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.029 0.155 -0.190 0.000 0.000 0.005 0.000 0.000

psi5 0.057 0.018 0.039 0.000 0.000 0.000 0.010 0.000 0.000

psi6 0.004 0.045 0.001 0.000 0.000 0.285 0.011 0.000 0.000

psi7 0.063 0.187 0.109 0.000 0.000 0.001 0.000 0.000 0.058

psi8 0.777 1.856 0.691 0.113 0.000 0.000 0.000 0.000 0.058

psi9 -0.147 0.304 0.267 0.295 0.000 0.000 0.000 0.204 0.001

AlaLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.949 0.028 0.513 0.026 0.000 -0.059 0.160 0.313 0.117

psi2 0.016 -0.155 0.010 0.004 0.058 -0.064 0.036 0.004 0.003

psi3 0.006 0.129 -0.017 0.046 0.000 0.000 0.005 0.059 0.001

psi4 0.015 0.341 1.692 -0.214 0.000 0.003 0.059 0.069 0.007

psi5 0.091 0.719 0.337 0.029 0.000 0.006 0.714 0.382 0.003

psi6 -0.187 0.498 0.537 0.016 0.000 0.207 0.031 0.009 0.000

psi7 0.077 0.572 -0.067 -0.244 0.003 0.019 0.012 0.004 0.001

psi8 -0.954 1.971 3.868 0.397 0.000 0.030 0.037 0.012 0.065

psi9 -3.279 1.826 0.413 0.663 0.000 0.001 0.099 0.054 -0.380

AlaLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.193 -0.092 1.305 0.086 0.000 0.030 0.212 0.147 0.385

psi2 0.015 0.041 0.162 0.030 0.004 0.108 0.240 0.053 0.028

psi3 0.080 0.097 -1.000 -0.141 0.072 0.037 -0.985 0.000 0.058

psi4 -0.036 0.238 -2.875 0.686 0.016 0.000 0.151 0.129 0.050

psi5 0.465 1.540 -1.560 0.756 0.001 0.054 0.703 0.624 0.018

psi6 0.147 -0.859 -0.488 0.001 0.002 0.957 1.346 0.026 0.001

psi7 0.227 1.039 3.806 0.077 0.018 0.214 -0.052 0.247 0.042

psi8 0.150 1.974 -0.190 -3.241 0.021 0.001 -2.484 0.033 0.347

psi9 1.499 5.327 -4.733 -3.880 0.030 0.015 0.322 0.092 -1.702

AlaLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.237 0.016 0.162 0.001 0.023 1.248 0.362 0.008 0.039

psi2 -0.489 0.555 0.045 0.017 0.004 0.860 0.971 0.035 0.058

psi3 0.145 0.354 -0.511 0.308 -0.250 0.023 0.370 0.030 0.005

psi4 0.075 -1.608 -4.957 -2.652 0.032 0.060 0.484 0.277 0.036

psi5 0.267 -4.532 1.614 0.060 0.004 0.006 0.678 0.483 0.022

psi6 0.391 -1.936 -1.371 -0.891 0.009 0.831 2.040 0.010 0.056

psi7 -0.859 -3.208 -0.770 0.163 0.068 -1.241 -0.133 -0.235 0.032

psi8 -0.297 2.107 -3.587 -0.760 0.058 0.030 0.094 0.003 -0.070

psi9 0.341 2.055 2.450 0.313 0.000 0.000 0.028 0.055 0.064

GlyHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.031 0.005 -0.336 0.000 0.000 0.003 -0.420 0.000 0.000

psi2 0.002 0.001 -0.263 0.000 0.000 -0.077 -0.047 0.000 0.000

psi3 0.004 0.033 0.386 -0.988 0.036 0.000 0.000 0.000 0.000

psi4 0.018 0.881 4.086 6.951 0.000 0.000 0.000 0.002 0.000

psi5 -0.168 1.305 1.519 -0.356 0.000 0.000 -0.332 0.036 -0.086

psi6 0.046 -1.461 -0.610 0.013 0.000 0.015 -0.041 0.000 0.000

psi7 0.034 0.268 0.067 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.020 0.091 0.083 0.161 0.000 0.000 0.002 -0.245 -0.055

psi9 -0.121 0.651 0.825 0.012 0.000 0.000 -0.138 -0.175 -0.380

GlyHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.032 0.024 -0.570 0.000 0.000 -0.005 -0.477 -0.174 0.000

psi2 0.000 -0.203 0.003 0.000 0.000 -0.627 -1.545 0.000 0.000

psi3 0.002 0.004 -1.847 3.336 0.001 0.000 0.000 0.000 0.000

psi4 0.000 0.692 5.457 5.560 0.033 0.000 0.001 0.001 0.017

psi5 0.002 1.398 5.563 0.716 0.000 0.005 -1.975 0.006 0.000

psi6 0.003 0.546 0.737 0.000 0.000 0.015 -1.820 -0.009 0.000

psi7 0.314 0.347 0.289 0.018 0.000 0.021 -0.003 0.000 0.000

psi8 0.075 0.127 1.269 0.162 0.000 0.000 0.001 0.001 0.000

psi9 0.835 1.009 1.394 0.043 0.000 0.000 -2.732 -0.198 -0.109

Glyhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 -0.392 0.000 0.000 0.001 -0.213 0.000 0.000

psi2 0.000 0.014 0.000 0.000 0.085 -0.720 -0.044 0.000 0.000

psi3 0.021 0.028 2.277 1.129 0.113 -0.040 0.001 0.000 0.001

psi4 0.101 1.011 8.582 5.553 0.085 0.000 0.002 0.000 0.000

psi5 0.001 1.653 3.904 0.467 0.000 0.003 -2.610 0.002 -0.087

psi6 0.004 0.226 0.094 0.000 0.000 0.023 -1.683 -0.089 0.000

psi7 0.003 0.015 0.009 0.000 0.000 -0.177 0.000 0.000 0.000

psi8 0.001 0.011 0.079 0.253 0.000 0.002 0.000 0.000 0.000

psi9 0.359 0.008 0.205 0.073 0.000 0.000 0.002 0.000 0.000

GlySB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -2.880 -0.983 -0.126 0.000 0.000 0.000 0.031 -0.316 -4.403

psi2 -0.095 -0.258 0.000 0.018 0.000 0.001 -0.054 0.003 -0.082

psi3 0.000 0.001 0.002 0.001 0.000 0.000 -0.032 0.000 0.000

psi4 0.000 0.131 0.095 0.182 0.000 0.000 0.000 0.000 0.000

psi5 0.033 0.159 0.013 0.085 0.000 0.000 -0.915 0.000 0.000

psi6 0.086 0.065 -0.273 0.002 0.000 0.014 0.001 0.000 0.000

psi7 0.011 0.278 0.692 0.000 0.000 0.005 0.000 0.000 0.000

psi8 2.017 5.805 2.772 0.103 0.000 0.000 0.000 -0.061 0.002

psi9 1.196 3.562 0.147 0.083 0.000 0.000 0.001 -0.298 -1.061

GlySM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -2.865 0.357 0.367 0.000 0.000 0.000 -1.348 -0.506 -8.036

psi2 -0.904 0.000 0.000 0.000 0.000 0.000 -0.183 0.000 -0.503

psi3 0.000 0.002 0.029 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.976 0.202 0.037 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.284 0.255 0.001 0.000 0.000 -0.020 0.000 0.000

psi6 0.000 0.108 0.111 0.000 0.000 0.038 -0.134 0.000 0.000

psi7 0.327 0.440 0.978 0.000 0.000 0.001 0.000 0.000 -1.380

psi8 2.744 10.078 4.664 0.302 0.002 0.000 0.000 -0.856 -0.528

psi9 2.612 5.775 2.556 0.201 0.000 0.000 -0.977 -0.521 -0.671

Glyse

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.925 -0.166 0.009 0.000 0.000 0.000 -0.041 0.000 -0.008

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.861 0.629 0.006 0.000 0.000 -0.041 0.000 0.000

psi5 0.085 0.031 0.048 0.000 0.000 0.000 -0.139 0.000 0.000

psi6 0.004 0.019 0.000 0.000 0.000 0.033 -0.266 0.000 0.000

psi7 0.508 0.089 0.133 0.000 0.000 0.000 0.000 0.000 0.085

psi8 1.451 2.966 2.023 0.223 0.000 0.000 0.000 0.000 0.085

psi9 0.624 1.761 1.064 0.421 0.000 0.000 0.000 0.000 0.001

GlyLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.279 -0.724 -1.727 -0.210 0.000 -1.001 -1.351 -0.567 -0.313

psi2 0.012 0.082 -0.184 0.005 -0.733 -0.613 -0.475 0.002 0.002

psi3 0.003 0.128 -0.210 -0.101 0.000 0.000 0.004 -0.732 0.001

psi4 0.005 0.282 3.317 0.417 0.000 0.002 -0.090 -0.053 0.004

psi5 0.070 1.370 0.895 0.058 0.000 0.004 -4.855 -1.579 0.001

psi6 0.140 0.006 0.027 0.019 0.000 -0.554 -3.289 -0.062 -0.055

psi7 0.520 0.420 1.091 0.038 0.002 0.035 -0.184 0.002 0.000

psi8 1.005 2.914 5.381 1.240 0.000 0.018 -0.151 -0.704 0.089

psi9 2.158 2.063 2.387 0.859 0.000 0.000 -0.733 -0.143 -1.330

Glylm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -1.065 -0.226 -2.488 0.016 0.000 0.028 -7.822 -3.696 -2.359

psi2 -0.561 -0.355 -0.322 -0.469 0.002 -0.490 -1.762 -0.001 -0.260

psi3 0.106 0.081 0.375 0.231 0.105 0.033 -0.239 0.000 -0.732

psi4 0.061 0.738 3.340 1.474 0.018 0.000 0.000 -5.044 -0.160

psi5 0.191 -0.014 2.999 0.504 0.001 0.035 -11.876 -11.116 0.020

psi6 0.525 1.383 0.842 0.001 -1.180 0.012 -4.468 -0.428 0.001

psi7 0.335 1.351 1.927 0.073 0.020 -0.349 0.092 -0.243 0.042

psi8 1.701 3.731 6.777 2.418 0.012 0.024 -0.376 -2.052 -0.318

psi9 1.646 4.025 2.230 2.773 -0.021 0.018 -9.977 -3.236 -1.129

GlyLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.059 -0.303 -1.609 0.001 0.034 -1.753 -3.623 -0.353 -0.317

psi2 0.096 -0.476 -0.016 0.019 0.008 -4.474 -5.920 -0.254 -0.732

psi3 -0.862 0.222 -1.060 0.105 0.019 -0.406 -1.092 -0.239 0.003

psi4 0.161 0.618 5.485 1.917 0.026 -1.646 -11.089 -5.017 -0.068

psi5 -0.319 -2.485 2.049 -0.338 0.004 -0.369 -18.840 -11.639 0.029

psi6 -3.746 0.956 0.968 0.129 0.004 1.550 -11.153 0.002 -0.244

psi7 0.866 2.364 0.697 0.042 0.068 0.031 0.216 0.018 0.001

psi8 0.256 2.644 5.010 2.292 -0.004 -0.235 -1.554 -0.107 0.075

psi9 0.997 4.073 3.309 2.447 0.000 0.000 -2.638 -0.115 0.107

ProHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.009 0.003 0.003 0.000 0.000 0.002 0.016 0.000 0.000

psi2 0.001 0.000 0.015 0.000 0.000 0.006 0.002 0.000 0.000

psi3 0.004 0.026 0.200 0.294 0.013 0.000 0.000 0.000 0.000

psi4 0.012 0.151 11.072 4.319 0.000 0.000 0.000 0.002 0.000

psi5 0.016 1.843 1.844 0.168 0.000 0.000 0.007 0.007 0.000

psi6 0.041 0.076 0.082 0.009 0.000 0.009 0.006 0.000 0.000

psi7 0.011 0.119 0.050 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.007 0.081 0.190 -0.403 0.000 0.000 0.001 0.008 0.000

psi9 0.016 0.014 0.084 0.004 0.000 0.000 0.004 0.002 0.001

ProHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.010 0.283 0.020 0.000 0.000 0.001 0.014 0.015 0.000

psi2 0.000 0.000 0.002 0.000 0.000 0.014 0.002 0.000 0.000

psi3 0.001 0.002 0.759 1.441 0.001 0.000 0.000 0.000 0.000

psi4 0.000 0.294 13.163 0.101 0.044 0.000 0.001 0.000 0.013

psi5 0.001 0.761 1.855 -0.144 0.000 0.003 0.040 0.004 0.000

psi6 0.002 0.397 -0.910 0.000 0.000 0.044 0.013 0.000 0.000

psi7 0.042 0.059 -0.021 -0.182 0.000 0.015 0.000 0.000 0.000

psi8 0.015 0.096 -1.994 0.164 0.000 0.000 0.001 0.569 0.000

psi9 0.426 0.110 0.735 -1.816 0.000 0.000 0.026 0.012 0.001

ProHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.004 0.000 0.000 0.000 0.002 0.000 0.000

psi2 0.000 0.010 0.000 0.000 0.044 0.025 0.003 0.000 0.000

psi3 0.015 0.017 0.183 -1.874 0.017 0.001 0.000 0.000 0.001

psi4 0.075 0.720 5.163 -4.739 0.044 0.000 0.002 0.000 0.000

psi5 0.001 0.467 -0.096 -1.500 0.000 0.001 0.079 0.001 0.001

psi6 0.006 0.083 0.059 0.000 0.000 0.074 0.024 0.001 0.000

psi7 0.005 0.143 0.009 0.000 0.000 0.013 0.000 0.000 0.000

psi8 0.000 0.009 0.068 0.006 0.000 0.001 0.000 0.000 0.000

psi9 0.245 0.343 -0.377 -3.671 0.000 0.000 0.001 0.000 0.000

ProSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.196 0.103 -0.211 0.000 0.000 0.000 0.003 0.018 0.090

psi2 0.001 0.017 0.000 0.016 0.000 0.000 0.001 0.002 0.005

psi3 0.000 0.001 0.001 0.000 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.046 0.054 0.003 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.077 0.008 0.044 0.000 0.000 0.049 0.000 0.000

psi6 0.045 0.005 -0.014 0.001 0.000 0.006 0.001 0.000 0.000

psi7 0.006 0.502 0.163 0.000 0.000 0.002 0.000 0.000 0.000

psi8 0.909 6.192 1.919 -0.546 0.000 0.000 0.000 0.000 0.001

psi9 4.164 3.932 -0.896 -0.264 0.000 0.000 0.000 0.016 0.040

ProSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.581 0.334 -0.690 0.000 0.000 0.000 0.024 0.028 0.146

psi2 0.066 0.000 0.000 0.000 0.000 0.000 0.004 0.000 0.000

psi3 0.000 0.001 0.016 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.071 0.109 -0.867 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.168 0.467 0.000 0.000 0.000 0.002 0.000 0.000

psi6 0.000 0.051 -0.113 0.000 0.000 0.012 0.004 0.000 0.000

psi7 0.156 0.415 0.276 0.000 0.000 0.000 0.000 0.000 0.131

psi8 1.588 3.933 -1.862 -0.074 0.002 0.000 0.000 0.000 0.160

psi9 3.127 5.447 -1.021 -0.157 0.000 0.000 0.052 0.582 0.080

ProSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.088 0.109 0.004 0.000 0.000 0.000 0.003 0.000 0.000

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.010 0.130 0.004 0.000 0.000 0.002 0.000 0.000

psi5 0.044 0.020 -0.005 0.000 0.000 0.000 0.019 0.000 0.000

psi6 0.002 0.019 0.000 0.000 0.000 0.022 0.008 0.000 0.000

psi7 0.046 0.492 -1.003 0.000 0.000 0.000 0.000 0.000 0.044

psi8 0.356 1.823 -1.522 -1.094 0.000 0.000 0.000 0.000 0.044

psi9 0.921 0.481 -0.114 -0.914 0.000 0.000 0.000 0.000 0.000

ProLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.055 0.183 -0.013 0.017 0.000 0.022 0.068 0.029 0.030

psi2 0.006 0.063 0.004 0.002 0.044 0.030 0.017 0.002 0.001

psi3 0.002 0.075 0.047 0.301 0.000 0.000 0.002 0.044 0.000

psi4 0.006 0.127 0.420 -1.253 0.000 0.001 0.031 0.040 0.003

psi5 0.041 0.370 -0.267 -0.086 0.000 0.002 0.211 0.117 0.001

psi6 0.035 0.282 -0.415 -0.260 0.000 0.185 0.235 0.004 0.000

psi7 0.082 0.520 0.073 0.033 0.001 0.278 0.351 0.001 0.000

psi8 0.649 2.541 1.192 -1.402 0.000 0.010 0.033 0.005 0.046

psi9 2.334 2.757 -7.097 -2.152 0.000 0.000 0.064 0.154 0.149

ProLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.245 0.013 -1.777 -0.348 0.000 0.022 0.843 0.125 0.125

psi2 0.020 0.069 -1.267 -0.349 0.001 0.184 0.034 0.004 0.019

psi3 0.059 0.130 0.089 -0.654 0.063 0.025 0.067 0.000 0.044

psi4 0.044 0.847 1.645 -3.261 -0.260 0.000 0.485 0.066 0.019

psi5 0.070 2.284 -4.354 -1.406 0.000 0.027 1.314 0.132 0.017

psi6 0.096 0.518 -0.351 0.001 0.001 0.809 0.354 0.015 0.000

psi7 0.173 -0.873 -1.972 -0.033 0.018 0.211 0.085 0.035 0.030

psi8 0.563 3.287 -1.666 -6.022 -0.449 0.000 0.116 0.014 0.104

psi9 1.908 3.955 -9.807 -5.698 0.020 0.016 0.334 0.068 0.169

ProLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.064 0.134 -1.065 0.000 0.011 0.007 0.093 0.003 0.037

psi2 0.037 0.035 0.022 0.017 0.005 0.281 0.142 0.013 0.044

psi3 0.077 -0.147 -0.904 -0.109 0.019 0.019 0.914 0.026 0.002

psi4 0.087 0.718 -5.535 -7.795 0.018 0.028 0.446 0.124 0.023

psi5 0.144 2.901 -4.547 -1.070 0.002 0.117 2.201 0.097 0.028

psi6 0.264 0.112 -2.129 -2.224 0.006 1.444 0.904 0.003 0.029

psi7 0.224 0.616 -5.333 -0.308 0.043 0.136 0.155 0.014 0.001

psi8 0.210 2.180 -4.288 -8.521 0.024 0.029 0.057 0.001 0.062

psi9 0.602 0.546 -13.207 -6.377 0.000 0.000 0.016 0.005 0.057

AsnHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.026 0.058 -0.106 0.000 0.000 0.003 0.034 0.000 0.000

psi2 0.002 0.001 0.011 0.000 0.000 0.008 0.002 0.000 0.000

psi3 -0.035 -0.064 0.348 0.355 0.046 0.000 0.000 0.000 0.000

psi4 0.016 0.213 12.194 6.231 0.000 0.000 0.000 0.002 0.000

psi5 0.013 0.118 2.230 0.177 0.000 0.000 0.008 0.006 0.000

psi6 0.077 0.483 0.077 0.007 0.000 0.012 0.054 0.000 0.000

psi7 0.028 -0.146 0.111 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.020 -0.114 -0.493 0.014 0.000 0.000 0.002 0.024 0.000

psi9 0.091 0.017 0.161 0.008 0.000 0.000 0.005 0.003 0.003

AsnHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.217 -0.007 -0.265 0.000 0.000 0.001 0.031 0.011 0.000

psi2 0.000 0.001 0.002 0.000 0.000 -0.274 0.026 0.000 0.000

psi3 0.001 -0.030 -0.229 -0.313 0.001 0.000 0.000 0.000 0.000

psi4 0.000 0.269 1.145 3.176 0.052 0.000 0.001 0.000 0.009

psi5 0.002 -1.262 1.672 0.684 0.000 0.003 0.060 0.624 0.000

psi6 0.002 -1.191 -2.237 0.000 0.000 0.146 0.015 0.000 0.000

psi7 -0.622 -0.292 -0.749 0.010 0.000 -0.177 0.000 0.000 0.000

psi8 -2.766 -0.131 -0.607 -0.656 0.000 0.000 0.001 0.001 0.000

psi9 -0.154 -2.695 -0.105 0.034 0.000 0.000 0.073 0.010 0.001

Asnhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 -0.229 0.010 0.000 0.000 0.001 0.003 0.000 0.000

psi2 0.000 0.008 0.000 0.000 0.044 0.013 0.193 0.000 0.000

psi3 0.010 0.014 1.178 -0.716 0.421 0.003 0.001 0.000 0.002

psi4 0.091 0.620 0.772 -2.412 0.044 0.000 0.002 0.000 0.000

psi5 0.001 -0.580 -3.346 -0.709 0.000 0.002 -0.353 0.002 0.002

psi6 0.007 0.260 -0.098 0.000 0.000 -0.411 -1.004 0.001 0.000

psi7 -0.202 0.062 -1.197 0.000 0.000 -0.024 0.000 0.000 0.000

psi8 0.000 -0.046 -0.895 0.269 0.000 0.002 0.000 0.000 0.000

psi9 0.002 1.543 -1.391 0.054 0.000 0.000 0.001 0.000 0.000

AsnSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.174 -0.017 0.066 0.000 0.000 0.000 0.003 0.038 0.102

psi2 0.004 0.013 0.000 0.012 0.000 0.001 0.001 0.002 0.005

psi3 0.000 0.001 0.001 0.001 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.073 0.069 0.003 0.000 0.000 0.000 0.000 0.000

psi5 0.001 0.006 0.009 0.044 0.000 0.000 0.050 0.000 0.000

psi6 0.045 0.008 0.018 0.001 0.000 -0.152 0.001 0.000 0.000

psi7 0.008 0.543 1.458 0.000 0.000 0.004 0.000 0.000 0.000

psi8 0.889 8.122 3.658 0.085 0.000 0.000 0.000 0.000 0.001

psi9 2.628 5.751 1.770 0.077 0.000 0.000 0.000 0.013 -0.002

AsnSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.425 0.027 0.155 0.000 0.000 0.000 0.028 0.060 0.263

psi2 0.093 0.000 0.000 0.000 0.000 0.000 0.014 0.000 0.000

psi3 0.000 0.001 0.011 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.292 0.157 0.033 0.000 0.000 0.000 0.000 0.000

psi5 0.000 -0.647 0.568 0.001 0.000 0.000 0.002 0.000 0.000

psi6 0.000 -0.103 0.055 0.000 0.000 0.008 0.012 0.000 0.000

psi7 0.101 0.176 -1.196 0.000 0.000 0.000 0.000 0.000 0.131

psi8 1.411 6.780 -3.296 0.217 0.002 0.000 0.000 0.000 0.152

psi9 1.593 3.918 -0.783 0.108 0.000 0.000 0.069 0.025 0.085

AsnSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.730 0.077 0.007 0.000 0.000 0.000 0.005 0.000 0.001

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.014 0.177 0.006 0.000 0.000 0.004 0.000 0.000

psi5 0.044 -0.150 -0.672 0.000 0.000 0.000 0.010 0.000 0.000

psi6 -0.039 -1.006 0.000 0.000 0.000 -0.959 -0.027 0.000 0.000

psi7 0.055 -0.223 0.173 0.000 0.000 0.000 0.000 0.000 -0.774

psi8 -2.487 0.560 0.732 0.102 0.000 0.000 0.000 0.000 0.044

psi9 -0.303 0.733 -0.874 -0.592 0.000 0.000 0.000 0.000 0.001

AsnLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.003 0.139 0.797 0.016 0.000 0.019 0.407 0.031 0.116

psi2 0.008 0.063 0.004 0.004 0.044 0.028 0.020 0.002 0.002

psi3 0.002 0.091 0.122 0.022 0.000 0.000 0.002 0.044 0.000

psi4 0.005 0.374 1.087 0.016 0.000 0.001 0.039 0.463 0.003

psi5 -0.100 0.100 1.381 0.033 0.000 -0.188 0.542 0.107 0.001

psi6 -0.228 -0.263 -1.070 0.008 0.000 -0.522 -0.240 0.006 0.000

psi7 -0.526 -0.123 -1.679 0.027 0.001 0.028 0.005 0.002 0.000

psi8 -0.165 1.866 1.130 1.525 0.000 0.015 0.287 0.005 0.047

psi9 1.149 2.043 2.616 0.794 0.000 0.000 0.067 0.043 0.114

AsnLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.901 0.481 -0.367 0.006 0.000 0.020 0.130 0.467 0.170

psi2 0.023 0.068 -0.078 0.005 0.001 0.034 0.415 0.007 0.004

psi3 0.061 -0.068 -0.707 0.179 0.002 0.017 0.112 0.000 0.044

psi4 0.042 0.501 1.753 0.339 0.013 0.000 -0.022 0.094 0.024

psi5 -0.008 -2.538 0.881 0.224 0.000 -0.111 -1.151 0.191 0.014

psi6 -0.961 -1.187 -0.116 0.001 0.001 -3.263 -0.081 0.011 0.000

psi7 -1.479 -0.819 -3.246 -0.224 0.014 -0.304 0.003 0.016 0.024

psi8 -0.408 -0.891 -0.194 -0.639 0.015 0.000 0.145 0.017 -0.747

psi9 1.319 -3.114 4.165 0.232 0.007 0.079 0.688 0.074 0.139

AsnLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.031 0.168 0.137 0.001 0.045 -0.024 0.256 0.004 0.031

psi2 0.101 0.044 0.028 0.013 0.007 -0.109 0.457 0.021 0.044

psi3 -0.168 0.312 0.072 -0.544 0.004 0.016 0.240 0.028 0.002

psi4 -3.787 -1.063 -2.378 1.347 0.017 0.045 -0.354 0.105 -0.066

psi5 0.007 -6.872 -4.833 0.301 -0.050 -1.209 0.253 0.316 -0.187

psi6 -0.110 -4.862 0.629 0.098 0.007 -3.944 -3.518 0.004 0.018

psi7 -0.153 -4.806 -2.153 -0.217 0.057 0.890 -0.542 0.010 0.001

psi8 -1.212 0.731 -4.673 -1.403 -0.206 -1.780 0.094 0.001 0.079

psi9 0.478 0.851 0.519 -0.675 0.000 0.000 0.027 0.031 0.046

ThrHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.016 0.005 0.005 0.000 0.000 0.004 0.027 0.001 0.000

psi2 -0.087 0.001 0.021 0.000 0.000 0.009 0.003 0.000 0.000

psi3 0.004 0.034 0.367 0.432 0.013 0.000 0.000 0.000 0.000

psi4 0.198 -0.146 4.954 0.954 0.000 0.000 0.000 0.002 0.000

psi5 0.023 0.643 0.644 -1.076 0.000 0.000 0.010 0.009 0.000

psi6 0.078 0.074 0.071 0.012 0.000 0.014 0.015 0.000 0.000

psi7 0.019 0.347 0.067 0.000 0.000 0.001 0.000 0.000 0.000

psi8 -0.018 0.030 0.079 0.055 0.000 0.000 0.001 0.015 0.000

psi9 0.033 -0.028 0.107 0.010 0.000 0.000 0.006 0.004 0.002

ThrHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.017 0.369 0.040 0.000 0.000 0.001 0.209 0.017 0.000

psi2 0.000 0.001 0.003 0.000 0.000 0.250 0.015 0.000 0.000

psi3 0.002 0.004 1.790 -2.926 0.001 0.000 0.000 0.000 0.000

psi4 0.000 -0.210 4.722 4.316 0.040 0.000 0.001 0.001 0.014

psi5 0.002 0.367 -1.824 0.784 0.000 0.114 0.068 0.006 0.000

psi6 0.002 0.080 0.945 0.000 0.000 0.186 0.020 0.000 0.000

psi7 0.054 0.423 0.187 0.016 0.000 0.023 0.001 0.000 0.000

psi8 0.187 0.214 0.022 0.073 0.000 0.000 0.001 0.001 0.000

psi9 -0.343 -5.679 -1.538 0.042 0.000 0.000 0.044 0.028 0.094

Thrhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.014 0.000 0.000 0.001 0.003 0.000 0.000

psi2 0.000 0.014 0.000 0.000 0.023 0.016 0.005 0.000 0.000

psi3 0.020 0.018 1.550 1.693 0.129 0.002 0.001 0.000 0.002

psi4 0.055 -1.462 6.919 -3.656 0.024 0.000 0.002 0.000 0.000

psi5 0.001 0.014 -4.547 0.587 0.000 0.002 0.157 0.002 0.002

psi6 0.015 -1.691 0.092 0.000 0.000 0.095 0.045 0.002 0.000

psi7 0.015 0.011 0.025 0.000 0.000 0.017 0.000 0.000 0.000

psi8 0.000 0.026 0.088 0.048 0.000 0.002 0.000 -1.797 0.000

psi9 0.003 -0.985 -4.091 -0.318 0.000 0.000 0.002 0.000 0.000

ThrSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.413 -0.266 0.052 0.000 0.000 0.000 0.004 0.030 0.452

psi2 0.007 0.018 0.000 0.016 0.000 0.001 0.002 0.003 0.006

psi3 0.000 0.001 0.002 0.001 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.099 0.091 0.004 0.000 0.000 0.000 0.000 0.000

psi5 0.001 0.116 0.014 0.023 0.000 0.000 0.030 0.000 0.000

psi6 0.024 0.009 0.011 0.001 0.000 0.012 0.001 0.000 0.000

psi7 0.010 0.299 0.273 0.000 0.000 0.004 0.000 0.000 0.000

psi8 0.207 4.565 4.619 0.082 0.000 0.000 0.000 0.000 0.002

psi9 1.062 0.232 0.885 0.059 0.000 0.000 0.001 0.015 0.048

ThrSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.234 0.202 0.086 0.000 0.000 0.000 0.083 0.039 0.288

psi2 0.089 0.000 0.000 0.000 0.000 0.000 0.019 0.000 0.000

psi3 0.000 0.001 0.023 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.897 0.564 0.027 0.000 0.000 0.000 0.000 0.000

psi5 0.000 -0.275 0.031 0.001 0.000 0.000 0.003 0.000 0.000

psi6 0.000 0.036 0.039 0.000 0.000 0.022 0.016 0.000 0.000

psi7 -0.707 0.111 0.235 0.000 0.000 0.001 0.000 0.000 0.069

psi8 1.926 -3.414 -0.970 -1.528 0.002 0.000 0.000 0.000 -0.176

psi9 2.371 -4.673 2.072 -1.770 0.000 0.000 0.039 0.036 0.169

ThrSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.132 0.052 0.008 0.000 0.000 0.000 0.005 0.000 0.001

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.041 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.077 0.056 0.006 0.000 0.000 0.004 0.000 0.000

psi5 0.023 -0.073 0.036 0.000 0.000 0.000 0.011 0.000 0.000

psi6 0.004 0.013 0.000 0.000 0.000 0.030 0.010 0.000 0.000

psi7 0.026 0.281 0.142 0.000 0.000 0.000 0.000 0.000 0.023

psi8 0.648 -2.177 -2.359 0.107 0.000 0.000 0.000 0.000 0.023

psi9 0.270 -5.539 -1.730 0.150 0.000 0.000 0.000 0.000 0.001

ThrLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.067 -0.049 -0.173 0.023 0.000 0.280 0.071 0.038 0.074

psi2 0.010 0.041 0.006 0.004 0.023 0.117 0.025 0.002 0.002

psi3 0.003 0.105 0.190 -0.229 0.000 0.000 0.003 0.024 0.001

psi4 0.008 -0.607 2.787 0.376 0.000 -0.189 0.049 0.111 0.067

psi5 0.055 0.535 -0.741 0.219 0.000 0.003 0.534 0.122 0.001

psi6 0.047 0.441 -0.188 0.017 0.000 0.204 0.556 0.007 0.000

psi7 0.476 -0.219 0.214 0.035 0.001 0.033 0.006 0.002 0.000

psi8 0.091 0.737 2.443 0.059 0.000 -0.172 0.033 0.007 0.027

psi9 -1.965 0.291 3.570 -0.253 0.000 0.000 0.082 0.047 0.150

ThrLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.593 -0.980 -0.090 0.016 0.000 0.053 0.368 0.150 0.154

psi2 0.017 -0.183 -0.163 0.015 0.002 0.060 0.050 0.006 0.014

psi3 -0.149 0.083 0.148 -1.222 0.040 0.028 0.195 0.000 0.023

psi4 -0.293 -1.740 -1.727 0.144 0.017 0.000 0.482 0.076 0.040

psi5 0.197 -3.715 -0.534 0.352 0.001 -0.067 0.723 0.216 0.018

psi6 -0.067 0.859 0.575 0.001 0.001 1.216 0.900 0.018 0.001

psi7 0.360 0.322 1.205 0.076 0.019 0.631 0.175 0.031 0.036

psi8 2.073 -0.570 2.815 2.156 -0.069 0.000 0.383 0.019 0.080

psi9 -0.508 -5.402 0.589 3.938 0.017 0.017 0.204 0.120 0.120

ThrLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.067 0.125 0.229 0.001 0.012 0.122 0.146 0.005 0.040

psi2 0.063 0.049 0.189 0.018 0.009 0.176 0.175 0.046 0.024

psi3 -0.007 0.174 -1.053 0.502 0.015 0.021 0.599 0.034 0.002

psi4 -0.737 -2.089 -2.663 -1.836 0.025 0.025 0.644 0.283 -0.159

psi5 -0.810 -4.104 -2.978 0.169 0.004 0.127 2.103 0.326 0.027

psi6 0.317 -0.176 0.026 0.051 0.015 0.493 -1.390 0.005 0.033

psi7 -0.143 -0.503 1.141 0.112 -0.024 0.165 0.106 0.016 0.001

psi8 0.322 -2.527 -2.734 1.444 0.039 0.030 0.102 0.002 -0.085

psi9 -1.706 -5.774 -0.915 1.093 0.000 0.000 0.028 0.014 0.022

SerHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.015 0.005 0.006 0.000 0.000 0.004 0.030 0.001 0.001

psi2 0.002 0.001 0.020 0.000 0.348 0.011 -0.021 0.000 0.000

psi3 0.005 0.029 0.743 0.641 0.200 0.000 0.000 0.000 0.000

psi4 0.020 0.408 4.875 5.239 0.000 0.000 0.000 0.003 0.000

psi5 0.026 -0.572 0.440 0.382 0.000 0.000 0.012 0.008 0.000

psi6 0.215 0.652 0.114 0.012 0.000 -0.040 0.017 0.000 0.000

psi7 0.019 0.074 0.000 0.000 0.000 0.001 0.000 0.000 0.000

psi8 -0.077 -0.016 -1.132 -0.329 0.000 0.000 -0.088 0.013 0.001

psi9 -0.066 0.177 -0.254 -0.329 0.000 0.000 0.007 0.004 0.002

SerHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.017 -1.338 0.047 0.000 0.000 0.002 0.022 0.014 0.000

psi2 0.000 0.001 0.003 0.000 0.000 0.024 0.020 0.000 0.000

psi3 0.003 0.005 1.716 -2.342 -0.001 0.000 0.000 0.000 0.000

psi4 0.000 0.113 1.392 3.188 0.069 0.000 0.002 0.001 0.014

psi5 0.002 -0.715 2.100 2.518 0.000 0.053 0.021 0.138 0.001

psi6 0.003 0.212 0.059 0.000 0.000 0.279 0.024 0.000 0.000

psi7 0.155 1.089 0.111 0.016 0.000 0.019 0.001 0.000 0.000

psi8 0.370 -3.130 -0.171 -0.724 0.000 0.000 0.001 0.001 0.000

psi9 -4.996 0.961 -3.695 -0.198 0.000 0.000 0.042 0.014 0.001

Serhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.002 -0.291 0.001 0.000 0.001 0.004 0.000 0.000

psi2 0.000 0.014 0.000 0.000 0.064 -0.099 0.257 0.000 0.000

psi3 0.023 0.018 -0.478 2.127 0.200 0.002 0.001 0.000 0.002

psi4 0.144 1.062 -2.320 6.040 0.065 0.000 0.003 0.000 0.000

psi5 -0.215 0.312 -1.135 0.623 0.000 0.002 0.113 0.002 0.002

psi6 0.010 0.301 0.102 0.000 0.000 0.990 0.631 0.001 0.000

psi7 0.006 0.016 0.013 0.000 0.000 -0.488 0.000 0.000 0.000

psi8 0.001 0.014 0.057 0.014 0.000 0.002 0.000 0.000 0.000

psi9 0.004 -0.484 -2.917 0.055 0.000 0.000 -0.088 0.000 0.000

SerSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.362 0.302 0.097 0.000 0.000 0.000 0.005 0.191 0.141

psi2 0.008 0.019 0.000 0.017 0.000 0.001 0.002 0.003 0.007

psi3 0.000 0.002 0.002 0.001 0.000 0.000 0.001 0.000 0.000

psi4 0.000 -0.040 0.040 -0.028 0.000 0.000 0.000 0.000 0.000

psi5 0.001 0.205 -0.175 0.065 0.000 0.000 0.076 0.000 0.000

psi6 -0.752 0.011 0.020 0.002 0.000 0.014 0.001 0.000 0.000

psi7 0.065 -0.016 0.431 0.000 0.000 0.005 0.000 0.000 0.000

psi8 0.537 7.511 3.209 0.122 0.000 0.000 0.000 0.000 0.002

psi9 -0.142 0.615 -1.513 -0.215 0.000 0.000 0.001 0.009 0.097

SerSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.560 0.473 -2.071 0.000 0.000 0.000 0.018 0.040 0.729

psi2 -0.682 0.000 0.000 0.000 0.000 0.000 0.022 0.000 0.000

psi3 0.000 0.002 0.018 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.414 0.512 0.048 0.000 0.000 0.000 0.000 0.000

psi5 0.000 -0.248 0.066 0.001 0.000 0.000 0.004 0.000 0.000

psi6 0.001 0.082 0.083 0.000 0.000 0.200 0.019 0.000 0.000

psi7 0.229 -0.289 0.389 0.000 0.000 0.001 0.000 0.000 0.193

psi8 -0.316 1.611 3.423 1.054 0.002 0.000 0.000 0.000 -0.033

psi9 -3.644 0.171 -2.460 -0.659 0.000 0.000 0.079 0.038 0.081

SerSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.130 -0.061 0.009 0.000 0.000 0.000 0.006 0.000 0.001

psi2 0.001 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.018 -0.706 0.008 0.000 0.000 0.005 0.000 0.000

psi5 0.064 0.019 0.004 0.000 0.000 0.000 0.009 0.000 0.000

psi6 0.004 0.007 0.001 0.000 0.000 0.033 0.532 0.000 0.000

psi7 0.237 0.188 0.392 0.000 0.000 0.000 0.000 0.000 0.064

psi8 0.703 0.974 0.005 0.328 0.000 0.000 0.000 0.000 0.064

psi9 -3.666 0.082 0.514 0.308 0.000 0.000 0.000 0.000 0.001

SerLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.456 0.328 0.054 -0.022 0.000 0.029 -0.252 0.043 0.035

psi2 0.092 -0.111 0.007 0.005 0.064 -0.445 0.025 0.003 0.002

psi3 0.004 0.085 0.144 0.034 0.000 0.000 0.003 0.065 0.001

psi4 0.007 0.283 -1.445 0.394 0.000 0.002 -0.223 0.051 0.005

psi5 0.014 0.494 0.920 -0.127 0.000 0.004 0.351 0.177 0.002

psi6 -0.111 0.550 0.328 0.018 0.000 1.382 0.241 0.008 0.000

psi7 0.406 1.012 1.289 -0.239 -0.189 -0.094 -0.010 0.003 0.000

psi8 -0.261 1.522 3.981 0.696 0.000 0.019 0.048 0.008 0.069

psi9 0.584 1.481 2.123 0.758 0.000 0.000 0.351 0.048 -0.106

SerLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.410 -1.507 0.073 0.024 0.000 0.028 0.628 0.175 0.039

psi2 0.033 -0.005 0.163 0.023 -0.188 -0.077 0.056 0.008 0.022

psi3 0.082 -0.133 0.163 0.141 0.097 0.028 0.125 0.000 0.065

psi4 -0.219 -0.389 1.662 -1.705 -1.034 0.000 0.470 0.367 0.041

psi5 0.256 -2.145 -0.520 0.302 0.001 0.044 1.872 0.285 0.020

psi6 0.150 -0.184 -0.105 0.001 0.002 0.644 -0.384 0.019 0.001

psi7 0.247 0.839 -1.941 -0.133 0.020 0.082 -0.097 -0.237 0.581

psi8 0.475 2.755 0.604 -3.459 0.022 0.000 0.320 0.023 0.128

psi9 -2.383 -3.880 -3.079 1.825 0.026 0.018 0.267 0.110 -0.030

SerLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.061 -1.341 -0.368 0.001 0.101 0.172 0.123 0.006 0.079

psi2 -2.749 -0.331 0.142 0.019 0.006 0.489 0.241 0.028 0.065

psi3 0.091 2.734 0.461 -3.306 0.023 0.023 -3.739 0.040 0.003

psi4 0.038 -3.127 -3.877 0.989 -0.109 0.066 -0.614 0.127 -0.193

psi5 -0.473 -0.856 -5.778 -5.478 0.006 0.221 1.862 0.402 0.042

psi6 0.960 0.476 -1.755 0.150 0.010 0.924 0.437 0.006 0.041

psi7 0.397 0.116 0.028 -2.456 0.137 0.219 0.095 0.017 0.001

psi8 0.301 -0.910 -1.730 -5.003 0.042 -0.834 0.118 0.002 -0.280

psi9 -2.628 -0.156 -4.513 0.948 0.000 0.000 0.029 0.016 0.069

ArgHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.017 0.004 0.004 0.000 0.000 0.003 0.023 0.001 0.000

psi2 0.002 0.001 0.017 0.000 0.000 0.009 0.004 0.000 0.000

psi3 0.002 0.026 0.413 0.680 0.080 0.000 0.000 0.000 0.000

psi4 0.017 0.383 11.160 10.707 0.000 0.000 0.000 0.002 0.000

psi5 0.018 0.574 2.175 0.943 0.000 0.000 0.010 0.008 0.000

psi6 0.319 0.051 0.249 0.009 0.000 0.182 0.013 0.000 0.000

psi7 0.020 0.057 0.052 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.027 0.062 0.483 0.043 0.000 0.000 0.001 0.016 0.000

psi9 0.026 0.019 0.162 0.007 0.000 0.000 0.006 0.003 0.001

ArgHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.257 0.103 0.036 0.000 0.000 0.206 0.025 0.013 0.000

psi2 0.000 0.001 0.003 0.000 0.000 0.017 0.018 0.000 0.000

psi3 0.002 0.004 -1.233 -1.318 0.001 0.000 0.000 0.000 0.000

psi4 0.000 2.226 -2.377 -1.004 0.066 0.000 0.001 0.001 0.018

psi5 0.002 0.346 1.873 0.938 0.000 0.003 0.053 0.187 0.000

psi6 0.002 -0.492 -0.296 0.000 0.000 -0.287 0.114 0.000 0.000

psi7 0.860 0.086 0.325 0.013 0.000 0.020 0.001 0.000 0.000

psi8 0.175 0.094 -0.244 0.142 0.000 0.000 0.001 0.001 0.000

psi9 0.196 2.102 0.851 0.039 0.000 0.000 0.045 0.013 0.220

ArgHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.435 0.000 0.000 0.001 0.003 0.000 0.000

psi2 0.000 0.012 0.000 0.000 0.051 0.011 0.016 0.000 0.000

psi3 0.014 0.034 -4.248 -8.084 -1.406 0.002 0.001 0.000 0.002

psi4 0.145 -1.379 -5.698 -6.576 0.051 0.000 0.002 0.000 0.000

psi5 0.001 0.817 -0.413 -3.070 0.000 0.002 0.084 0.002 0.002

psi6 0.004 0.513 -0.204 0.000 0.000 -0.587 -0.188 0.001 0.000

psi7 0.006 0.006 0.011 0.000 0.000 0.013 0.000 0.000 0.000

psi8 0.000 0.264 -0.509 -0.294 0.000 0.002 0.000 0.000 0.000

psi9 0.003 0.026 1.374 0.042 0.000 0.000 0.001 0.000 0.000

ArgSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.251 0.293 0.076 0.000 0.000 0.000 0.004 0.027 0.107

psi2 0.006 0.017 0.000 0.016 0.000 0.001 0.002 0.003 0.004

psi3 0.000 0.001 0.002 0.001 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.077 0.079 0.004 0.000 0.000 0.000 0.000 0.000

psi5 0.001 -0.072 0.012 0.051 0.000 0.000 0.054 0.000 0.000

psi6 0.052 0.007 0.012 0.001 0.000 0.014 0.001 0.000 0.000

psi7 0.009 0.274 0.325 0.000 0.000 0.002 0.000 0.000 0.000

psi8 0.900 6.742 3.500 0.073 0.000 0.000 0.000 0.000 -0.189

psi9 1.851 3.376 0.948 0.047 0.000 0.000 0.001 0.010 0.052

ArgSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.446 0.310 1.727 0.000 0.000 0.000 0.013 0.129 0.218

psi2 0.084 0.000 0.000 0.000 0.000 0.000 0.011 0.000 0.000

psi3 0.000 0.001 0.015 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -1.143 -0.178 0.031 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.188 0.378 0.001 0.000 0.000 0.003 0.000 0.000

psi6 0.000 0.064 0.061 0.000 0.000 0.021 0.011 0.000 0.000

psi7 0.177 0.086 -0.176 0.000 0.000 0.000 0.000 0.000 0.152

psi8 -0.012 -3.033 -2.252 -0.013 0.002 0.000 0.000 0.000 0.185

psi9 -1.001 -4.178 0.328 0.129 0.000 0.000 0.067 0.038 0.092

ArgSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.102 -0.419 0.011 0.000 0.000 0.000 0.004 0.000 0.001

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.010 -1.562 0.004 0.000 0.000 0.002 0.000 0.000

psi5 -0.767 0.012 0.406 0.000 0.000 0.000 0.008 0.000 0.000

psi6 0.002 -0.722 0.000 0.000 0.000 0.018 0.014 0.000 0.000

psi7 0.053 -0.392 0.294 0.000 0.000 0.000 0.000 0.000 0.051

psi8 -1.491 -4.789 -2.949 -2.005 0.000 0.000 0.000 0.000 0.051

psi9 -1.375 -2.213 -1.209 -0.267 0.000 0.000 0.000 0.000 0.001

ArgLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.183 0.004 0.255 0.015 0.000 0.024 0.058 0.030 0.026

psi2 0.008 0.073 0.006 0.002 0.051 0.032 0.019 0.002 0.002

psi3 0.003 -0.040 0.103 0.031 0.000 0.000 0.059 0.051 0.001

psi4 0.007 0.204 0.177 0.303 0.000 0.001 0.043 0.136 0.004

psi5 0.045 0.934 1.912 0.054 0.000 0.003 0.911 0.127 0.001

psi6 0.047 0.826 0.283 0.016 0.000 0.214 0.333 0.005 0.000

psi7 0.089 0.334 1.840 0.033 0.001 0.029 0.118 0.002 0.000

psi8 0.481 1.749 2.263 1.571 0.000 0.015 0.029 0.007 -0.136

psi9 0.376 2.950 3.153 0.339 0.000 0.000 0.067 0.035 0.149

ArgLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.318 0.343 1.517 0.023 0.000 0.024 0.196 0.136 0.606

psi2 0.010 -1.100 -0.063 0.023 0.002 0.084 0.066 0.004 0.022

psi3 0.063 0.057 -0.686 0.094 0.061 0.035 0.080 0.000 0.051

psi4 -0.093 0.500 -3.384 0.084 0.016 0.000 0.351 0.351 0.039

psi5 0.190 0.229 0.707 0.480 0.000 0.039 1.430 0.214 0.017

psi6 -0.283 -1.176 -0.778 0.001 0.001 0.324 0.129 0.021 0.001

psi7 0.359 0.085 0.888 0.058 0.018 -0.025 0.086 0.037 0.033

psi8 -0.452 -0.315 -0.398 0.667 0.019 0.000 0.413 0.110 0.108

psi9 0.269 -0.539 -1.656 0.721 0.023 0.016 0.262 0.070 0.169

ArgLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.077 0.301 -1.031 0.001 0.078 0.112 0.065 0.005 0.038

psi2 0.115 0.017 -0.164 0.017 0.002 0.829 -1.110 0.018 0.046

psi3 0.110 0.199 0.574 0.435 0.023 0.020 0.650 0.077 0.002

psi4 0.109 -2.320 -2.759 0.599 0.020 0.052 0.496 0.397 0.029

psi5 -0.142 0.362 -2.881 -2.372 0.002 -2.316 3.226 1.013 0.015

psi6 0.332 0.116 -3.425 0.122 0.004 -3.129 0.787 0.005 0.036

psi7 0.207 -2.230 0.165 -2.836 0.118 -0.028 0.157 0.019 0.001

psi8 0.506 -1.373 -2.230 -0.384 0.028 0.023 0.064 0.002 -0.176

psi9 -2.669 -3.105 -0.445 -0.888 0.000 0.000 0.015 0.007 0.054

GlnHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.008 0.004 0.004 0.000 0.000 0.003 0.014 0.000 0.000

psi2 0.002 0.001 0.012 0.000 0.000 0.008 0.003 0.000 0.000

psi3 0.003 0.021 0.348 1.248 0.057 0.000 0.000 0.000 0.000

psi4 0.009 0.136 4.610 3.903 0.000 0.000 0.000 0.002 0.000

psi5 0.011 1.013 1.506 0.143 0.000 0.000 0.008 0.007 0.000

psi6 0.215 0.070 0.047 0.007 0.000 0.012 0.009 0.000 0.000

psi7 0.011 0.262 0.050 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.018 0.067 -0.894 0.131 0.000 0.000 0.001 0.007 0.000

psi9 0.022 0.254 0.031 0.007 0.000 0.000 0.005 0.003 0.001

GlnHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.009 0.369 -0.063 0.000 0.000 0.001 0.014 0.010 0.000

psi2 0.000 0.001 0.002 0.000 0.000 0.015 0.006 0.000 0.000

psi3 0.001 -0.020 2.686 0.503 0.001 0.000 0.000 0.000 0.000

psi4 0.000 0.503 -4.040 1.850 0.065 0.000 0.001 0.000 0.010

psi5 0.001 0.026 0.871 1.428 0.000 0.003 -0.072 0.005 0.000

psi6 0.002 0.282 0.777 0.000 0.000 0.045 0.016 0.000 0.000

psi7 1.013 -1.815 0.053 0.012 0.000 0.010 0.000 0.000 0.000

psi8 0.194 -0.356 0.075 0.159 0.000 0.000 0.001 0.001 0.000

psi9 0.431 0.457 1.678 0.025 0.000 0.000 0.025 0.011 0.001

Glnhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.351 0.010 0.000 0.000 0.001 0.002 0.000 0.000

psi2 0.000 0.007 0.000 0.000 0.021 0.011 0.004 0.000 0.000

psi3 0.008 0.004 -2.827 -3.967 0.823 0.272 0.001 0.000 0.001

psi4 0.100 -0.475 -5.500 -5.975 0.021 0.000 0.002 0.000 0.000

psi5 0.001 -0.810 -4.604 -0.032 0.000 0.002 0.073 0.001 0.002

psi6 0.342 0.248 -1.053 0.000 0.000 -0.156 0.455 0.001 0.000

psi7 -0.402 0.007 0.009 0.000 0.000 0.007 0.000 0.000 0.000

psi8 0.000 -1.101 1.511 0.102 0.000 0.002 0.000 0.000 0.000

psi9 0.002 0.006 0.625 -0.159 0.000 0.000 0.001 0.000 0.000

GlnSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.163 0.089 0.044 0.000 0.000 0.000 0.004 0.019 0.078

psi2 0.003 0.015 0.000 0.014 0.000 0.001 0.001 0.002 0.004

psi3 0.000 0.001 0.001 0.001 0.000 0.000 0.001 0.000 0.000

psi4 0.000 -0.145 0.061 0.004 0.000 0.000 0.000 0.000 0.000

psi5 0.001 0.078 0.009 0.021 0.000 0.000 0.025 0.000 0.000

psi6 0.022 0.007 0.015 -0.190 0.000 0.009 0.001 0.000 0.000

psi7 0.008 0.296 -0.065 0.000 0.000 -0.043 0.000 0.000 0.000

psi8 0.694 3.899 2.778 0.075 0.000 0.000 0.000 0.000 0.001

psi9 2.801 3.718 1.604 0.038 0.000 0.000 0.001 0.011 0.037

GlnSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.259 -0.226 0.016 0.000 0.000 0.000 0.022 0.028 0.164

psi2 0.059 0.000 0.000 0.000 0.000 0.000 0.010 0.000 0.000

psi3 0.000 0.001 0.006 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.093 -0.307 0.033 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.118 -0.081 0.001 0.000 0.000 0.003 0.207 0.000

psi6 0.000 0.208 0.029 0.000 0.000 0.012 0.009 0.000 0.000

psi7 0.083 -0.164 -0.498 0.000 0.000 0.000 0.000 0.000 0.062

psi8 -0.532 -2.907 -0.638 0.077 0.001 0.000 0.000 0.000 0.087

psi9 -2.754 -2.400 1.082 0.061 0.000 0.000 0.029 0.383 0.046

GlnSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.042 0.059 0.007 0.000 0.000 0.000 0.004 0.000 0.001

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.015 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.010 0.052 0.004 0.000 0.000 0.003 0.000 0.000

psi5 0.021 0.014 0.016 0.000 0.000 0.000 0.005 0.000 0.000

psi6 0.003 0.016 0.000 0.000 0.000 -0.284 0.007 0.000 0.000

psi7 0.033 0.086 0.050 0.000 0.000 0.000 0.000 0.000 0.021

psi8 -0.105 -1.988 0.088 0.077 0.000 0.000 0.000 0.000 0.021

psi9 -0.089 -0.744 0.839 -0.706 0.000 0.000 0.000 0.000 0.000

GlnLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.086 0.346 0.185 0.011 0.000 0.022 0.055 0.493 0.027

psi2 0.008 0.065 0.005 -0.040 0.021 0.030 0.015 0.005 0.002

psi3 0.003 0.223 0.074 0.023 0.000 0.000 -0.087 0.021 0.000

psi4 0.006 0.153 1.286 0.869 0.000 0.001 0.036 0.036 0.003

psi5 0.032 0.150 1.947 0.038 0.000 0.003 1.166 0.088 0.001

psi6 0.073 -0.162 0.218 0.015 0.000 -0.500 0.482 0.006 0.000

psi7 0.077 0.521 1.445 0.030 0.001 -0.164 0.005 0.002 0.000

psi8 0.409 1.601 0.075 -0.139 0.000 0.010 0.040 0.005 0.023

psi9 1.341 1.458 2.556 0.512 0.000 0.000 0.062 0.037 0.126

Glnlm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.195 0.813 0.438 0.008 0.000 0.021 0.519 0.104 0.107

psi2 0.028 0.060 0.084 0.008 0.001 0.051 -0.089 0.004 0.007

psi3 0.030 0.041 0.175 0.176 0.049 0.019 0.120 0.000 0.021

psi4 0.040 -0.397 -2.188 0.557 0.015 0.000 0.114 0.054 -0.325

psi5 -1.827 -0.422 -0.283 0.057 0.001 0.019 1.757 0.025 0.016

psi6 0.061 0.748 -0.129 0.001 0.001 -0.698 1.457 0.021 0.000

psi7 0.137 0.828 -0.186 0.047 0.016 0.030 0.059 0.021 0.025

psi8 -0.274 2.600 0.793 1.570 0.017 0.000 0.283 0.193 0.046

psi9 -0.395 -0.546 3.652 0.288 0.010 0.015 0.432 0.054 0.108

Glnle

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.119 0.258 0.142 0.001 0.056 0.176 0.197 0.003 0.033

psi2 0.121 0.101 0.017 0.015 0.003 -0.409 -0.149 0.012 -1.160

psi3 -0.386 0.165 -0.185 -2.651 0.008 -0.259 0.267 0.026 0.002

psi4 0.103 -1.486 -4.621 -6.436 0.011 0.022 0.266 1.058 0.005

psi5 0.031 -1.831 -1.295 0.250 0.003 0.084 1.096 0.552 -0.542

psi6 0.125 -4.360 0.279 0.042 0.005 -1.195 1.016 0.005 0.083

psi7 0.010 -0.666 -3.645 0.157 0.072 0.269 0.103 0.011 0.001

psi8 -1.843 -2.654 -4.802 1.458 0.021 0.016 0.078 0.001 -2.897

psi9 -0.568 -1.645 -0.672 0.651 0.000 0.000 0.039 0.008 0.024

AspHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.360 0.004 -0.028 0.000 0.000 0.004 0.222 0.001 0.000

psi2 0.002 0.001 0.021 0.000 0.000 0.009 0.005 0.000 0.000

psi3 0.003 0.034 0.314 0.457 0.047 0.000 0.000 0.000 0.000

psi4 0.021 0.085 8.882 7.858 0.000 0.000 0.000 0.002 0.000

psi5 0.023 0.537 0.847 0.187 0.000 0.000 0.010 0.010 0.000

psi6 0.392 -0.175 0.092 0.010 0.000 0.587 0.015 0.000 0.000

psi7 0.028 0.069 0.425 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.016 0.077 -0.841 0.052 0.000 0.000 0.001 0.023 0.001

psi9 -0.196 0.020 0.651 -0.220 0.000 0.000 0.006 0.005 0.001

AspHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.675 0.003 -0.170 0.000 0.000 0.001 0.034 0.017 0.000

psi2 0.000 0.001 -0.087 0.000 0.000 -0.034 0.019 0.000 0.000

psi3 0.002 0.047 0.072 0.696 0.047 0.000 0.000 0.000 0.000

psi4 0.000 0.390 0.574 2.365 0.020 0.000 0.001 0.001 0.017

psi5 0.002 -0.249 3.111 -0.777 0.000 0.006 0.314 0.365 0.000

psi6 -0.220 -0.990 -0.379 0.000 0.000 -0.020 0.021 0.000 0.000

psi7 -1.782 -0.477 -2.454 0.019 0.000 0.021 0.000 0.000 0.000

psi8 0.102 -2.052 -2.583 -0.914 0.000 0.000 0.001 0.001 0.000

psi9 -0.146 1.232 -0.544 0.039 0.000 0.000 0.062 0.017 0.001

Asphe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.009 0.001 0.014 0.000 0.000 0.001 0.003 0.000 0.000

psi2 0.000 0.012 0.000 0.000 0.046 0.061 0.005 0.000 0.000

psi3 0.019 0.018 -2.656 1.768 0.081 0.002 0.001 0.000 0.001

psi4 0.047 -0.451 1.198 3.542 0.046 0.000 0.026 0.000 0.000

psi5 0.001 0.878 -4.984 -0.801 0.000 0.002 -0.002 0.002 0.002

psi6 0.007 -0.664 0.086 0.000 0.000 -4.688 0.033 0.001 0.000

psi7 0.091 -0.191 -0.818 0.000 0.000 0.015 0.000 0.000 0.000

psi8 0.000 -0.121 -1.101 0.012 0.000 0.002 0.000 0.000 0.000

psi9 0.535 -0.438 0.359 -0.153 0.000 0.000 0.002 0.000 0.000

AspSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.578 0.929 -0.907 0.000 0.000 0.000 0.004 0.037 0.586

psi2 0.008 0.015 0.000 0.014 0.000 0.001 0.002 0.003 0.071

psi3 0.000 -0.029 0.002 0.001 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.072 0.072 0.004 0.000 0.000 0.000 0.000 0.000

psi5 0.001 0.070 0.012 0.046 0.000 0.000 0.052 0.000 0.000

psi6 0.047 -0.035 0.016 0.001 0.000 0.019 0.001 0.000 0.000

psi7 0.010 0.321 0.611 0.000 0.000 0.003 0.000 0.000 0.000

psi8 0.806 6.563 5.021 0.087 0.000 0.000 0.000 0.000 0.002

psi9 2.793 4.845 2.377 0.055 0.000 0.000 0.001 0.007 0.324

AspSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.980 0.293 0.550 0.000 0.000 0.000 0.021 0.063 0.574

psi2 0.091 0.000 0.000 0.000 0.000 0.000 0.007 0.000 0.000

psi3 0.000 0.001 -0.169 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.193 0.335 0.083 0.000 0.000 0.000 0.000 0.000

psi5 0.000 -0.271 0.008 0.001 0.000 0.000 0.003 0.000 0.000

psi6 0.000 0.058 -1.230 0.000 0.000 -0.284 0.003 0.000 0.000

psi7 0.174 -0.466 -1.996 0.000 0.000 0.001 0.000 0.000 0.138

psi8 0.104 0.725 0.938 0.488 0.002 0.000 0.000 0.000 -0.648

psi9 2.753 3.583 1.470 0.121 0.000 0.000 0.070 0.321 0.079

AspSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.093 0.057 -0.145 0.000 0.000 0.000 0.005 0.000 0.001

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.013 0.264 0.049 0.000 0.000 0.003 0.000 0.000

psi5 0.046 -0.006 0.044 0.000 0.000 0.000 0.008 0.000 0.000

psi6 0.003 0.010 0.000 0.000 0.000 0.017 -0.489 0.000 0.000

psi7 0.049 0.035 0.075 0.000 0.000 0.000 0.000 0.000 0.046

psi8 0.891 0.627 0.520 0.082 0.000 0.000 0.000 0.000 0.046

psi9 -0.353 1.363 0.627 -0.580 0.000 0.000 0.000 0.000 0.001

AspLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.173 0.303 0.442 0.019 0.000 0.024 0.261 0.031 0.029

psi2 0.009 0.079 0.006 0.003 0.046 0.032 0.022 0.002 0.002

psi3 0.003 -0.163 0.113 0.060 0.000 0.000 0.003 0.047 0.001

psi4 0.214 -0.043 1.447 0.375 0.000 0.001 0.054 0.049 0.004

psi5 0.054 0.463 1.084 0.042 0.000 0.003 0.997 0.105 0.001

psi6 0.057 0.551 0.215 0.015 0.000 0.652 0.229 0.006 0.000

psi7 -0.364 -0.590 -2.033 0.030 0.001 0.114 0.006 0.003 0.000

psi8 0.629 2.467 1.634 1.866 0.000 0.021 0.040 0.007 0.050

psi9 1.974 2.497 1.759 0.746 0.000 0.000 0.247 0.036 0.129

AspLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.105 0.252 -1.679 0.012 0.000 0.570 0.275 0.120 0.380

psi2 0.021 0.303 0.133 -0.007 0.002 0.255 0.363 -0.050 0.010

psi3 -0.032 0.074 -0.001 0.184 0.066 -0.224 0.000 0.000 0.046

psi4 0.060 0.263 0.140 0.859 0.014 0.000 0.124 0.129 0.044

psi5 -0.308 0.491 -3.088 0.357 0.001 0.032 -0.736 0.239 0.016

psi6 -0.319 -0.436 0.594 0.001 0.001 -0.346 -2.146 0.021 0.001

psi7 -1.317 -3.174 -0.790 -0.768 -0.266 -0.117 -0.242 0.023 0.037

psi8 -0.930 -1.063 -3.535 0.605 0.018 0.000 0.468 0.394 -0.964

psi9 1.651 -0.378 -3.063 -0.975 0.012 -0.500 0.576 0.087 0.223

Asple

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.716 -0.262 -2.845 0.001 0.045 0.431 0.056 0.005 -0.091

psi2 0.085 0.051 0.027 0.015 0.007 0.818 0.212 0.101 0.047

psi3 -0.177 -0.993 -0.973 -0.120 0.010 0.018 0.144 0.032 0.003

psi4 0.031 -1.591 -2.702 -0.062 -0.169 -0.455 -2.450 0.168 0.031

psi5 -0.473 -1.853 -8.544 0.525 0.049 0.196 1.836 0.339 0.029

psi6 -0.459 -5.172 -1.872 0.141 -0.853 -3.924 -0.296 -0.209 0.030

psi7 -0.171 -0.181 -3.335 -2.701 -0.208 -0.428 -0.310 0.074 0.001

psi8 0.679 -4.056 2.723 -1.598 0.038 0.026 0.086 0.002 0.099

psi9 -0.742 0.921 -2.749 -4.836 0.000 0.000 0.003 0.010 0.050

LysHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.016 0.004 0.067 0.000 0.000 0.003 0.161 0.000 0.000

psi2 0.002 0.001 0.020 0.000 0.000 0.008 0.004 0.000 0.000

psi3 0.002 0.041 1.195 0.331 0.068 0.000 0.000 0.000 0.000

psi4 0.323 1.357 17.686 10.227 0.000 0.000 0.000 0.002 0.000

psi5 0.027 0.435 4.386 0.233 0.000 0.000 0.009 0.014 0.000

psi6 0.256 0.185 -0.101 0.011 0.000 0.012 0.009 0.000 0.000

psi7 0.018 0.072 0.082 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.033 0.101 0.078 0.052 0.000 0.000 0.001 0.014 0.000

psi9 0.023 0.080 0.184 0.006 0.000 0.000 0.006 0.004 0.002

LysHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.017 0.025 0.051 0.000 0.000 0.001 0.176 0.017 0.000

psi2 0.000 0.001 0.002 0.000 0.000 0.023 0.011 0.000 0.000

psi3 0.001 0.212 1.404 3.524 0.001 0.000 0.000 0.000 0.000

psi4 0.000 0.205 1.188 1.004 -2.737 0.000 0.001 0.001 0.020

psi5 0.002 2.330 1.294 1.007 0.000 0.007 -0.436 0.343 0.000

psi6 0.002 -0.645 -1.906 0.000 0.000 0.069 0.199 0.112 0.000

psi7 -0.038 -0.424 0.285 0.016 0.000 0.022 0.001 0.000 0.000

psi8 0.211 0.644 1.898 0.263 0.000 0.000 0.001 0.001 0.000

psi9 0.890 1.507 0.793 -0.336 0.000 0.000 0.108 0.025 0.012

Lyshe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.020 0.000 0.000 0.001 0.046 0.000 0.000

psi2 0.000 0.012 0.000 0.000 0.044 0.146 0.005 0.000 0.000

psi3 0.022 0.024 0.848 -1.340 -2.734 0.043 0.001 0.000 0.001

psi4 0.107 0.809 -6.506 -5.749 0.044 0.000 0.002 0.000 0.000

psi5 0.054 0.845 -8.347 -4.727 0.000 0.002 -0.329 0.002 0.002

psi6 0.010 -0.580 -0.015 0.000 0.000 0.359 0.035 0.001 0.000

psi7 0.012 0.016 0.017 0.000 0.000 0.015 0.000 0.000 0.000

psi8 -0.019 -1.245 -0.296 0.012 0.000 0.002 0.000 0.000 0.000

psi9 0.622 -0.600 -1.951 0.337 0.000 0.000 0.002 0.000 0.000

LysSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.276 0.279 0.064 0.000 0.000 0.000 0.004 0.024 0.371

psi2 0.003 0.013 0.000 0.012 0.000 0.001 0.001 0.002 0.009

psi3 0.000 0.314 0.001 0.001 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.060 0.215 0.004 0.000 0.000 0.000 0.000 0.000

psi5 0.001 0.621 0.012 0.044 0.000 0.000 0.054 0.000 0.000

psi6 0.045 0.006 0.007 0.001 0.000 0.012 0.001 0.000 0.000

psi7 0.009 0.493 0.373 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.579 8.659 4.745 -0.336 0.000 0.000 0.000 0.000 0.001

psi9 5.756 5.583 1.308 0.044 0.000 0.000 0.001 0.007 0.220

LysSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.390 0.307 0.163 0.000 0.000 0.000 0.022 0.041 0.599

psi2 0.078 0.000 0.000 0.000 0.000 0.000 0.273 0.000 0.000

psi3 0.000 0.001 0.017 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -2.583 -0.692 0.042 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.210 0.029 0.169 0.000 0.000 0.083 0.000 0.000

psi6 0.000 0.053 0.046 0.000 0.000 0.018 0.003 0.000 0.000

psi7 0.169 0.530 0.042 0.000 0.000 0.000 0.000 0.000 0.131

psi8 -1.935 0.414 -0.489 0.134 0.002 0.000 0.000 0.000 0.163

psi9 -0.356 -0.174 -1.381 -0.700 0.000 0.000 0.059 0.036 0.093

Lysse

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.088 -0.737 0.009 0.000 0.000 0.000 0.003 0.000 0.001

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.103 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.208 -0.634 0.005 0.000 0.000 0.001 0.000 0.000

psi5 0.044 0.016 -0.019 -0.018 0.000 0.000 0.028 0.000 0.000

psi6 0.002 0.016 0.000 0.000 0.000 -0.049 0.019 0.000 0.000

psi7 -0.771 0.077 -0.147 0.000 0.000 0.000 0.000 0.000 0.044

psi8 -1.224 -2.385 -4.329 -1.096 0.000 0.000 0.000 0.000 0.044

psi9 -3.752 -3.759 -2.245 0.128 0.000 0.000 0.000 0.000 0.000

Lyslb

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.071 -0.095 0.332 0.018 0.000 0.022 0.532 0.026 0.025

psi2 0.007 0.063 0.005 0.002 0.044 0.027 0.021 0.002 0.002

psi3 0.042 0.101 0.225 0.033 0.000 0.000 0.003 0.044 0.000

psi4 0.013 0.551 2.363 0.371 0.000 0.001 0.038 0.050 0.004

psi5 0.054 0.854 2.150 0.031 0.000 0.003 0.871 0.127 0.001

psi6 0.094 0.648 0.714 0.013 0.000 0.277 0.131 0.004 0.000

psi7 0.377 0.751 2.297 0.026 0.001 0.029 0.009 0.138 0.000

psi8 0.615 2.349 2.774 2.359 0.000 0.019 0.056 0.006 0.047

psi9 2.914 2.846 3.901 1.108 0.000 0.000 0.264 0.037 0.135

Lyslm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.267 -0.206 1.802 0.007 0.000 0.189 0.201 0.149 0.503

psi2 0.036 0.007 0.115 0.006 0.001 0.078 0.042 0.004 0.005

psi3 0.064 -0.005 -2.741 0.048 -0.497 0.039 -0.454 0.000 0.044

psi4 0.057 0.012 2.307 -0.889 0.013 0.000 -0.275 -0.386 0.031

psi5 0.268 1.308 2.380 -2.139 0.001 0.072 3.919 0.372 0.014

psi6 0.110 2.544 -0.133 0.001 0.001 -1.762 -0.381 0.021 0.000

psi7 0.070 -0.365 0.098 0.065 0.014 -0.328 -0.144 0.017 0.034

psi8 -0.012 -0.066 1.307 0.535 0.015 0.000 0.437 0.180 0.086

psi9 -0.530 0.737 3.747 1.118 0.006 0.012 0.364 0.081 0.111

Lysle

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.041 -0.245 -2.829 0.001 0.067 0.047 0.053 0.004 -0.040

psi2 0.104 -0.689 -0.063 0.013 0.007 -2.679 0.932 0.025 0.044

psi3 0.089 -0.153 -2.084 -0.724 -1.797 0.015 0.263 0.023 0.003

psi4 -0.840 -3.127 -7.893 -4.344 0.024 0.045 0.455 0.131 -0.067

psi5 -0.001 -2.368 -2.324 0.296 0.002 -0.218 0.516 0.146 -0.044

psi6 -0.558 -4.277 -7.530 0.123 0.011 -4.114 -3.374 0.005 0.023

psi7 -0.168 -2.800 -1.705 0.183 -2.816 0.190 -0.795 0.021 0.001

psi8 0.068 -2.579 -1.332 -4.583 0.034 -0.159 0.096 -0.189 0.118

psi9 -2.097 -2.963 -3.522 -4.702 0.000 0.000 0.025 0.009 0.045

GluHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.017 0.006 0.006 0.000 0.000 0.005 0.029 0.001 0.001

psi2 0.003 0.001 0.026 0.000 0.001 0.011 0.003 0.001 0.000

psi3 0.002 0.062 0.586 -0.255 0.058 0.000 0.000 0.000 0.000

psi4 0.027 0.906 8.652 8.950 0.000 0.000 0.000 0.003 0.000

psi5 0.032 -0.155 2.052 -0.576 0.000 0.000 0.013 0.015 0.000

psi6 -0.007 0.128 0.467 0.015 0.000 0.017 0.012 0.000 0.000

psi7 0.020 -0.085 0.091 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.025 0.096 0.187 0.069 0.000 0.000 0.002 0.015 0.001

psi9 0.164 0.399 0.181 0.009 0.000 0.000 0.022 0.005 0.002

GluHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.187 0.045 0.046 0.000 0.000 0.002 0.026 0.023 0.000

psi2 0.000 0.001 0.004 0.000 0.000 0.028 0.011 0.000 0.000

psi3 0.002 0.005 -5.559 1.682 0.001 0.000 0.000 0.000 0.000

psi4 0.000 0.641 -3.288 0.165 -0.126 0.000 0.002 0.001 -0.234

psi5 0.002 -1.039 -1.697 2.841 0.000 0.005 0.571 1.544 0.000

psi6 0.003 -0.237 0.259 0.000 0.000 0.079 0.067 0.000 0.000

psi7 -0.230 -0.035 -0.254 0.024 0.000 0.024 0.051 0.000 0.000

psi8 0.197 0.124 0.424 -0.076 0.000 0.000 0.001 0.001 0.000

psi9 0.432 0.482 -2.512 0.060 0.000 0.000 0.052 0.028 0.001

Gluhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.002 0.012 0.000 0.000 0.001 0.004 0.000 0.000

psi2 0.000 0.019 0.000 0.000 0.046 0.022 0.006 0.000 0.000

psi3 0.024 -0.312 -8.099 0.348 0.303 0.004 0.001 0.000 0.001

psi4 -2.682 -3.048 -7.895 -7.023 0.047 0.000 0.003 0.000 0.000

psi5 0.001 -1.653 -4.203 -1.817 0.000 0.002 -0.083 0.003 0.003

psi6 0.009 -0.536 0.088 0.000 0.000 0.083 0.103 0.002 0.000

psi7 0.013 0.015 0.019 0.000 0.000 0.020 0.000 0.000 0.000

psi8 0.000 -0.139 0.236 -0.713 0.000 0.003 0.000 0.000 0.000

psi9 0.004 0.010 0.419 -0.134 0.000 0.000 0.002 0.000 0.000

GluSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.304 0.134 0.075 0.000 0.000 0.000 0.005 0.029 0.230

psi2 0.003 0.017 0.000 0.016 0.000 0.001 0.002 0.003 0.008

psi3 0.000 0.002 0.033 0.001 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.147 0.093 0.820 0.000 0.000 0.000 0.000 0.000

psi5 0.001 0.110 0.014 0.047 0.000 0.000 0.055 0.000 0.000

psi6 0.048 0.009 0.013 0.001 0.000 -0.004 0.001 0.000 0.000

psi7 0.011 0.336 0.287 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.647 6.829 2.620 0.300 0.000 0.000 0.000 0.000 0.002

psi9 3.594 3.337 1.920 0.165 0.000 0.000 0.001 0.009 0.063

GluSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.746 -0.507 0.136 0.000 0.000 0.000 0.021 0.038 0.230

psi2 0.080 0.000 0.000 0.000 0.000 0.000 0.006 0.000 0.000

psi3 0.000 0.002 0.028 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.131 0.032 0.042 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.208 -0.159 0.001 0.000 0.000 0.004 0.000 0.000

psi6 0.001 0.056 0.047 0.000 0.000 0.020 0.005 0.000 0.000

psi7 0.125 -0.404 0.368 0.000 0.000 0.001 0.000 0.000 0.138

psi8 -1.022 -1.101 -0.515 -0.015 0.002 0.000 0.000 0.000 0.178

psi9 -1.678 1.262 0.210 0.129 0.000 0.000 0.062 0.046 0.384

Gluse

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.093 0.094 0.007 0.000 0.000 0.000 0.004 0.000 0.001

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.011 -0.742 0.005 0.000 0.000 0.002 0.000 0.000

psi5 0.046 0.444 0.088 0.000 0.000 0.000 -0.107 0.000 0.000

psi6 0.002 0.013 0.001 0.000 0.000 0.019 0.013 0.000 0.000

psi7 0.050 0.180 0.097 0.000 0.000 0.000 0.000 0.000 0.046

psi8 -1.707 -3.575 -1.575 0.425 0.000 0.000 0.000 0.000 0.046

psi9 -1.047 0.151 -0.424 0.312 0.000 0.000 0.000 0.000 0.001

GluLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.299 0.245 0.302 0.022 0.000 0.026 0.071 0.035 0.190

psi2 0.009 0.195 0.007 0.003 0.046 0.036 0.027 0.078 0.026

psi3 0.004 0.119 0.483 0.039 0.000 0.000 0.004 0.047 0.001

psi4 0.014 0.150 1.800 0.569 0.000 0.002 0.047 0.052 0.005

psi5 0.145 0.459 2.376 -0.216 0.000 0.004 0.753 0.160 0.002

psi6 0.126 0.204 0.519 0.017 0.000 0.236 0.158 0.006 0.000

psi7 0.092 0.639 0.911 0.035 0.002 -0.087 0.008 0.003 0.001

psi8 -0.121 -0.289 3.337 1.405 0.000 0.023 0.129 0.008 0.051

psi9 2.297 2.490 3.647 1.069 0.000 0.000 0.134 0.045 0.719

Glulm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.267 0.195 0.743 0.026 0.000 0.027 0.188 0.131 0.654

psi2 -0.061 0.092 0.138 0.026 0.002 0.411 0.065 0.006 0.024

psi3 0.070 0.096 0.000 -0.300 0.073 0.047 -0.145 0.000 0.046

psi4 0.068 1.601 1.000 0.884 0.017 0.000 -0.381 0.091 0.037

psi5 0.191 0.310 -0.027 -0.075 0.001 0.037 1.911 0.247 -0.258

psi6 0.130 0.905 -0.287 0.001 -0.189 0.690 -0.359 0.028 0.001

psi7 0.176 0.063 0.488 0.334 0.019 -0.579 -0.057 0.041 -0.155

psi8 0.582 0.184 3.001 1.238 0.021 0.000 1.897 0.020 0.195

psi9 -0.828 1.444 0.391 0.483 -0.253 0.017 0.562 0.158 0.496

Glule

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.209 -0.273 -1.208 0.001 0.056 0.169 -0.264 0.006 0.039

psi2 -0.087 -0.032 -0.463 0.018 0.006 -0.095 0.124 0.029 0.047

psi3 -1.359 0.016 -0.038 -0.627 0.026 0.022 0.243 0.030 0.003

psi 4 0.356 -0.472 -5.366 -4.346 0.035 0.048 0.295 0.148 0.029

psi5 -0.149 -1.573 -4.964 -0.049 0.003 0.333 1.414 0.602 0.040

psi6 0.063 -0.141 -0.840 0.100 0.009 0.479 -2.247 0.007 -0.146

psi7 0.057 -1.351 0.418 -0.264 0.103 -0.100 0.156 0.026 0.001

psi8 -2.857 -1.039 -5.057 -0.879 -0.193 0.035 -1.283 0.002 0.118

psi9 -4.223 -5.461 -0.763 -1.508 0.000 0.000 0.023 0.011 0.051

<Table 4>

Rama Onebody + Two-Body Score Parameter

CysHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.006 0.001 0.001 0.000 0.000 0.001 0.010 0.000 0.000

psi2 0.000 0.000 0.003 0.000 0.000 0.002 0.002 0.000 0.000

psi3 0.002 0.011 0.327 0.076 0.000 0.000 0.000 0.000 0.000

psi4 0.007 0.039 -5.518 -1.310 0.000 0.000 0.000 0.001 0.000

psi5 0.004 -0.382 -1.629 0.060 0.000 0.000 0.005 0.008 0.000

psi6 -0.511 -0.046 0.017 0.003 0.000 -0.019 0.002 0.000 0.000

psi7 -0.087 -0.062 -0.069 0.000 0.000 0.000 0.000 0.000 0.000

psi8 -0.561 -0.717 -0.290 -0.288 0.000 0.000 0.000 0.006 0.000

psi9 0.012 0.008 -0.659 0.034 0.000 0.000 0.001 0.001 0.000

CysHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.008 0.009 0.021 0.000 0.000 0.002 0.015 0.003 0.000

psi2 0.000 0.000 0.001 0.000 0.000 0.016 0.037 0.000 0.000

psi3 0.000 -0.470 0.349 -0.561 0.002 0.000 0.000 0.000 0.000

psi4 0.000 -1.382 -0.165 4.544 0.013 0.000 0.000 0.000 0.001

psi5 0.001 0.816 -1.316 -0.073 0.000 0.000 0.019 0.002 0.000

psi6 0.004 0.054 -0.826 0.000 0.000 0.021 0.004 0.000 0.000

psi7 0.038 0.213 0.356 0.007 0.000 0.003 0.000 0.000 0.000

psi8 -0.045 0.173 0.280 0.114 0.000 0.000 0.000 0.000 0.000

psi9 0.181 -0.379 0.302 0.021 0.000 0.000 0.042 0.012 0.000

Cyshe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.006 0.000 0.000 0.001 0.032 0.000 0.000

psi2 0.000 0.005 0.000 0.000 0.002 0.007 0.001 0.000 0.000

psi3 0.003 0.041 0.498 0.330 0.006 0.001 0.000 0.000 0.001

psi4 0.013 -0.286 6.933 2.001 0.003 0.000 0.046 0.000 0.000

psi5 0.001 0.388 0.302 0.067 0.000 0.000 0.289 0.003 0.000

psi6 0.005 0.033 0.013 0.000 0.000 0.106 0.028 0.000 0.000

psi7 0.008 0.003 0.012 0.000 0.000 0.007 0.000 0.000 0.000

psi8 0.001 0.078 0.200 0.016 0.000 0.000 0.000 0.000 0.000

psi9 0.003 0.021 0.175 0.031 0.000 0.000 0.000 0.000 0.000

CysSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.092 0.050 0.006 0.000 0.000 0.000 0.004 0.010 0.047

psi2 0.000 0.002 0.000 0.001 0.000 0.000 0.000 0.001 0.002

psi3 0.000 0.008 0.001 0.112 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.049 0.073 0.063 0.000 0.000 0.001 0.000 0.000

psi5 0.000 -0.254 -0.090 0.011 0.000 0.000 0.003 0.000 0.000

psi6 0.003 0.004 0.020 0.000 0.000 0.004 0.000 0.000 0.000

psi7 0.011 -0.380 0.394 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.561 -0.396 -1.370 0.037 0.000 0.000 0.000 0.000 0.000

psi9 -0.727 -4.594 -2.047 0.026 0.000 0.000 0.000 0.016 0.015

CysSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.528 0.110 0.063 0.000 0.000 0.000 0.028 0.214 0.075

psi2 0.003 0.008 0.000 0.000 0.000 0.000 0.002 0.000 0.004

psi3 0.000 0.001 0.006 0.002 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.029 0.069 0.100 0.000 0.000 0.000 0.000 0.000

psi5 0.000 0.017 0.034 0.001 0.000 0.000 0.003 0.031 0.000

psi6 0.001 0.007 0.003 0.000 0.000 0.008 0.075 0.000 0.000

psi7 0.099 0.034 -0.385 0.000 0.000 0.000 0.008 0.000 0.007

psi8 0.305 3.591 -0.905 -0.083 0.000 0.000 0.000 0.001 -0.014

psi9 -1.037 0.790 -0.352 0.015 0.000 0.000 0.009 0.015 0.050

Cysse

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.005 0.043 0.002 0.000 0.000 0.000 0.001 0.000 0.007

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.000 0.001 0.003 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.016 0.087 0.014 0.001 0.000 0.009 0.000 0.000

psi5 0.002 0.042 0.195 0.002 0.000 0.001 0.026 0.001 0.000

psi6 0.001 0.020 0.001 0.001 0.000 0.013 0.008 0.000 0.000

psi7 0.005 0.013 0.018 0.000 0.000 0.000 0.000 0.000 0.002

psi8 0.100 0.695 0.426 0.060 0.000 0.000 0.001 0.000 0.014

psi9 0.410 0.261 0.684 0.159 0.000 0.000 0.001 0.000 0.000

Cyslb

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.012 0.079 -0.060 0.002 0.000 0.005 0.035 0.007 0.020

psi2 0.003 0.017 0.001 0.000 0.002 0.008 0.011 0.001 0.001

psi3 0.003 0.033 0.031 0.006 0.000 0.008 0.001 0.064 0.000

psi4 -0.083 -1.052 -0.428 -0.058 0.000 0.000 0.016 0.024 0.002

psi5 -0.019 -1.397 -3.438 -0.034 0.000 0.001 0.061 0.472 0.000

psi6 0.259 0.205 0.125 0.002 0.000 -0.664 -0.255 0.001 0.000

psi7 -0.993 -0.544 0.400 0.003 0.008 -0.502 0.003 0.001 0.000

psi8 0.020 -2.744 -5.754 -1.667 0.000 0.010 0.003 0.024 0.003

psi9 -1.120 -2.381 -1.078 0.578 0.000 0.000 0.025 0.048 0.026

Cyslm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.238 0.315 0.171 0.012 0.000 0.004 0.108 0.112 0.044

psi2 0.001 -0.583 0.104 0.004 0.000 0.096 0.021 0.008 0.004

psi3 0.013 0.157 -0.036 0.053 0.003 0.003 0.006 0.000 0.003

psi4 -0.126 -0.132 0.358 0.172 0.002 0.000 0.042 0.034 0.003

psi5 0.059 -1.892 -1.388 0.199 0.000 0.008 -0.364 0.191 0.002

psi6 0.134 -0.215 0.280 0.000 0.017 0.171 0.477 0.006 0.001

psi7 -0.135 1.339 -0.493 0.030 0.018 0.042 0.037 0.005 0.020

psi8 0.201 -0.547 -4.206 -0.885 0.002 0.008 0.024 0.010 0.043

psi9 -0.282 -0.741 0.641 1.059 0.004 0.009 0.187 0.177 0.048

Cysle

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.038 0.097 -0.731 0.000 0.000 0.003 0.057 0.006 0.006

psi2 0.006 0.055 0.027 0.002 0.002 0.049 0.101 0.003 0.082

psi3 0.032 -0.110 0.179 0.074 0.012 0.003 0.034 0.019 0.001

psi4 0.043 1.321 3.761 1.518 0.013 0.009 0.118 0.050 0.004

psi5 0.076 0.963 3.659 0.155 0.007 0.023 2.211 0.177 0.002

psi6 0.039 -0.494 0.363 0.007 0.006 1.871 1.032 0.006 0.014

psi7 -0.384 0.604 0.408 0.020 -0.062 -0.539 0.044 0.002 0.003

psi8 0.108 1.018 2.526 1.375 0.006 0.007 0.037 0.001 0.014

psi9 0.302 1.603 3.102 0.591 0.000 0.000 0.048 0.001 -0.035

PheHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.116 0.003 0.003 0.000 0.000 0.004 0.035 0.000 0.000

psi2 0.003 0.001 0.010 0.000 0.000 0.008 0.003 0.000 0.000

psi3 -0.013 -0.159 -0.729 -0.809 0.001 0.000 0.000 0.000 0.000

psi4 0.011 -0.774 -4.056 -6.661 0.000 0.000 0.000 0.002 0.000

psi5 0.013 -1.763 -3.109 0.108 0.000 0.000 0.010 0.010 0.000

psi6 0.008 -0.268 -0.057 -0.080 0.000 0.035 -0.063 0.000 0.000

psi7 -0.150 -0.195 0.028 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.017 0.226 0.134 0.068 0.000 0.000 0.002 0.011 0.000

psi9 -0.078 -0.027 0.062 -0.119 0.000 0.000 0.005 0.005 0.000

PheHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.014 0.134 0.037 0.000 0.000 0.003 0.055 0.006 0.000

psi2 0.000 0.002 0.004 0.000 0.000 0.031 0.022 0.000 0.000

psi3 0.001 0.026 0.410 0.434 0.003 0.000 0.001 0.000 0.000

psi4 0.000 -1.483 -0.200 -1.652 0.030 0.000 0.001 0.000 0.045

psi5 0.003 -0.981 0.169 0.797 0.000 0.011 0.103 0.004 0.000

psi6 0.007 -1.060 0.600 0.000 0.000 0.034 0.013 0.000 0.000

psi7 0.334 0.275 0.332 0.006 0.000 0.016 0.002 0.000 0.000

psi8 0.052 0.134 0.438 0.276 0.000 0.000 0.001 0.000 0.000

psi9 0.103 -0.166 0.596 0.043 0.000 0.000 0.061 0.015 0.001

PheHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.002 0.007 0.000 0.000 0.002 0.003 0.000 0.000

psi2 0.000 0.004 0.000 0.000 0.022 0.046 0.007 0.000 0.000

psi3 0.010 0.009 0.248 0.452 0.004 0.002 0.000 0.000 0.002

psi4 -0.352 0.582 8.013 1.847 0.083 0.000 0.002 0.000 0.000

psi5 0.023 -0.551 1.981 0.182 0.000 0.002 0.040 0.006 0.003

psi6 0.022 -0.532 0.043 0.000 0.000 0.085 0.083 0.002 0.000

psi7 0.022 0.032 0.013 0.000 0.000 0.015 0.000 0.000 0.000

psi8 0.002 0.014 0.088 0.062 0.000 0.003 0.000 0.000 0.000

psi9 0.006 0.090 0.224 0.220 0.000 0.000 0.002 0.000 0.000

PheSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.229 0.140 0.046 0.000 0.000 0.000 0.030 0.029 0.555

psi2 0.000 0.010 0.000 0.009 0.000 0.001 0.001 0.002 0.003

psi3 0.000 0.009 0.087 0.065 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.157 0.073 -0.106 0.000 0.000 0.007 0.000 0.000

psi5 0.000 -0.232 0.091 0.022 0.000 0.000 0.022 0.001 0.000

psi6 0.022 0.013 0.019 0.000 0.000 0.006 0.001 0.000 0.000

psi7 0.028 -0.400 -0.719 0.000 0.000 0.004 0.000 0.000 0.000

psi8 0.199 0.288 -1.344 0.229 0.000 0.000 0.000 0.000 0.000

psi9 -6.082 -2.476 -0.184 -0.019 0.000 0.000 0.000 0.017 0.256

PheSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.042 0.572 -0.324 0.000 0.000 0.000 0.193 0.084 0.205

psi2 0.063 0.030 0.000 0.000 0.000 0.000 0.021 0.000 0.010

psi3 0.000 0.011 0.022 0.030 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.045 1.108 0.692 0.000 0.000 0.000 0.007 0.000

psi5 0.000 0.238 0.167 0.009 0.000 0.000 0.034 0.047 0.000

psi6 0.008 0.029 0.022 0.000 0.000 0.018 0.114 0.000 0.000

psi7 0.117 -0.587 0.082 0.000 0.000 0.000 0.087 0.000 -0.235

psi8 2.226 -3.790 -0.476 0.098 0.003 0.000 0.000 0.008 0.086

psi9 -5.268 -1.330 0.731 0.341 0.000 0.000 0.035 0.045 -0.261

PheSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.057 0.040 0.005 0.000 0.000 0.000 0.002 0.000 0.008

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.008 0.000 0.000

psi3 0.000 0.003 0.008 0.112 0.000 0.000 0.000 0.007 0.000

psi4 0.000 0.031 0.045 0.196 0.008 0.000 0.012 0.000 0.000

psi5 0.022 0.046 0.230 -0.091 0.000 0.002 -0.556 0.014 0.000

psi6 0.002 0.026 0.007 0.007 0.000 0.034 0.064 0.000 0.000

psi7 0.048 -0.137 0.138 0.000 0.000 0.000 0.000 0.000 0.029

psi8 0.258 1.702 0.996 0.196 0.000 0.000 0.008 0.000 0.022

psi9 -0.306 0.777 -0.112 0.171 0.000 0.000 0.008 0.000 0.000

PheLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.440 -0.071 0.223 0.006 0.000 0.097 0.074 0.071 0.018

psi2 0.009 0.045 0.008 0.001 0.094 0.028 0.017 0.001 0.003

psi3 0.032 0.212 -0.001 -0.095 0.000 0.008 0.003 0.022 0.000

psi4 -0.004 -1.715 -1.387 -0.677 0.000 0.000 0.042 0.038 0.007

psi5 0.038 -0.072 -2.393 0.029 0.000 -0.003 0.021 0.136 0.001

psi6 -0.100 -0.028 -0.078 0.010 0.000 0.365 0.179 0.300 0.000

psi7 0.132 -1.529 0.459 0.020 0.008 -0.123 0.007 0.001 0.000

psi8 -0.053 -1.099 0.510 -1.574 0.000 0.019 0.018 0.015 0.024

psi9 -2.672 -2.377 -1.031 0.050 0.000 0.000 0.154 0.286 0.356

PheLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.490 0.511 1.078 0.018 0.000 0.016 0.235 0.211 0.102

psi2 0.006 0.053 0.084 0.059 0.001 0.103 0.317 0.018 0.007

psi3 0.037 0.102 -0.079 -0.760 -0.125 0.263 0.040 0.000 0.092

psi4 0.006 0.285 1.014 0.717 0.011 0.000 0.092 0.081 0.018

psi5 -0.110 -1.745 -0.435 0.317 0.000 -0.061 1.425 0.273 0.010

psi6 0.087 -0.487 -0.950 0.000 0.004 0.641 0.739 0.020 0.004

psi7 -0.020 -0.077 -1.640 0.059 0.019 0.465 0.070 0.017 0.027

psi8 -0.211 -2.451 1.478 1.352 0.013 0.008 0.156 0.210 0.066

psi9 0.501 -1.956 2.672 0.462 0.008 0.017 0.307 0.220 0.171

PheLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.260 0.126 0.216 0.001 0.000 0.049 0.205 0.018 0.156

psi2 0.023 0.062 -0.349 0.011 0.005 0.153 0.149 0.014 0.028

psi3 0.081 0.151 0.295 0.223 0.008 0.013 0.021 0.036 0.002

psi4 0.212 0.410 3.998 2.745 0.008 0.042 0.289 0.092 0.020

psi5 0.136 -0.077 2.973 0.216 0.017 0.197 1.817 0.195 0.007

psi6 0.174 0.082 0.573 0.096 0.006 1.670 0.557 0.020 0.026

psi7 0.152 0.367 0.072 0.097 -0.123 0.175 0.115 0.012 0.004

psi8 0.210 1.346 2.346 0.711 -0.064 0.016 0.058 0.001 0.082

psi9 0.377 -1.522 1.988 0.463 0.000 0.000 0.034 0.004 0.098

LeuHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.018 0.007 0.007 0.000 0.000 0.008 0.033 0.001 0.001

psi2 0.006 0.002 0.030 0.000 0.001 0.019 0.006 0.001 0.000

psi3 0.010 0.054 -0.727 -2.588 0.026 0.000 0.000 0.000 0.000

psi4 0.092 -1.065 -9.161 -7.576 0.000 0.000 0.000 0.004 0.000

psi5 0.027 0.315 -6.225 0.383 0.000 0.000 0.053 0.046 0.000

psi6 0.006 -0.367 -0.445 0.009 0.000 0.125 0.226 0.000 0.000

psi7 0.278 0.171 0.123 0.000 0.000 0.002 0.000 0.000 0.000

psi8 0.153 0.159 0.125 -0.236 0.000 0.000 0.005 0.016 0.001

psi9 0.163 -0.620 -1.145 0.025 0.000 0.000 0.118 0.011 0.013

LeuHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.088 0.037 0.201 0.000 0.000 0.011 0.080 0.016 0.000

psi2 0.000 0.003 0.008 0.000 0.000 0.044 0.044 0.000 0.000

psi3 0.002 0.033 0.137 -0.424 0.006 0.000 0.001 0.000 0.000

psi4 0.001 -0.775 -6.535 -3.136 0.080 0.000 0.002 0.001 0.021

psi5 0.005 0.212 -1.865 1.048 0.000 0.002 0.159 0.689 0.001

psi6 0.014 1.556 0.603 0.000 0.000 -0.070 0.037 0.000 0.000

psi7 0.539 1.689 0.387 0.024 0.000 0.029 0.003 0.105 0.000

psi8 0.116 0.186 0.110 0.305 0.000 0.000 0.002 0.121 0.000

psi9 0.348 0.984 1.140 0.323 0.000 0.000 0.140 0.026 0.112

LeuHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.004 0.014 0.001 0.000 0.005 0.257 0.000 0.000

psi2 0.000 -0.066 0.000 0.000 0.035 0.030 0.017 0.000 0.000

psi3 0.035 0.020 -0.077 1.335 0.396 0.006 0.001 0.000 -0.039

psi4 0.165 -1.555 -0.408 4.876 0.027 0.000 0.004 0.001 0.000

psi5 0.118 0.445 0.612 0.506 0.000 0.038 0.187 0.048 0.006

psi6 -0.750 -1.750 -0.128 0.000 0.000 0.320 0.306 0.004 0.000

psi7 0.029 0.409 0.268 0.000 0.000 0.149 0.000 0.000 0.000

psi8 0.004 0.038 0.063 -0.213 0.000 -0.090 0.000 0.000 0.000

psi9 0.158 0.313 0.698 0.148 0.000 0.000 0.005 0.000 0.000

LeuSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.390 0.109 -0.262 0.000 0.000 0.000 0.019 0.063 1.008

psi2 0.031 0.022 0.000 0.020 0.000 -0.003 0.002 0.006 0.011

psi3 0.000 0.025 0.029 -0.045 0.000 0.000 0.002 0.000 0.000

psi4 0.000 -0.231 -1.921 -0.756 0.000 0.000 0.023 0.000 0.000

psi5 0.001 0.203 -0.089 0.049 0.000 0.000 0.028 0.102 0.000

psi6 0.029 -0.176 0.020 0.001 0.000 0.008 0.001 0.000 0.000

psi7 0.000 0.225 -1.216 0.000 0.000 0.007 0.000 0.000 0.000

psi8 -1.387 -3.246 -3.116 -0.474 0.000 0.000 0.000 0.000 0.110

psi9 5.448 -1.261 -1.677 0.082 0.000 0.000 0.001 0.075 0.112

LeuSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.372 0.212 0.159 0.000 0.000 0.000 0.166 0.095 0.305

psi2 0.045 0.082 0.000 0.000 0.000 0.000 0.036 0.000 0.016

psi3 0.000 0.028 0.106 0.090 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.329 -1.630 -0.192 0.000 0.000 0.000 0.022 0.000

psi5 0.000 -0.522 -0.237 0.025 0.000 0.000 -0.003 0.055 0.000

psi6 0.023 0.043 0.028 0.000 0.000 -0.089 0.126 0.000 0.000

psi7 0.219 0.227 -1.055 0.000 0.000 0.001 0.018 0.000 0.080

psi8 -0.664 1.501 -3.278 0.114 0.011 0.000 0.000 0.127 0.145

psi9 4.847 -0.981 -1.364 -0.284 0.000 0.000 0.093 0.142 0.154

LeuSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.159 0.143 0.004 0.000 0.000 0.000 0.005 0.000 0.024

psi2 0.001 0.000 0.000 0.000 0.000 0.000 0.023 0.000 0.000

psi3 0.000 -0.493 0.023 0.111 0.000 0.000 0.000 0.022 0.000

psi4 0.000 -0.010 0.020 0.655 0.055 0.000 0.025 0.000 0.000

psi5 0.027 0.135 0.347 0.106 0.000 0.005 0.091 0.060 0.000

psi6 0.006 0.070 0.022 0.023 0.000 0.057 0.052 0.000 0.000

psi7 0.097 0.153 0.156 0.000 0.000 0.003 0.000 0.000 0.097

psi8 -0.470 2.445 -0.849 0.310 0.000 0.000 0.023 0.000 0.073

psi9 0.341 1.149 0.249 0.532 0.000 0.000 0.022 0.000 0.001

LeuLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.232 0.315 0.761 0.049 0.000 0.038 0.111 0.145 0.094

psi2 0.042 0.340 0.107 0.002 0.027 0.228 0.234 0.004 0.005

psi3 0.009 0.155 0.105 0.048 0.000 0.019 0.008 0.119 0.001

psi4 0.021 -0.329 -1.700 -1.460 0.000 0.001 -0.264 0.141 0.054

psi5 0.093 -1.601 -1.016 0.070 0.000 -0.106 0.674 0.291 0.002

psi6 0.091 -1.080 -2.699 0.127 0.000 0.227 0.033 0.006 0.000

psi7 -0.142 -0.259 0.149 0.044 0.018 -0.072 0.014 0.003 0.001

psi8 -0.438 -0.250 -3.906 -1.755 0.000 0.040 0.038 0.034 -0.366

psi9 2.431 0.530 -3.432 -1.117 0.000 0.001 0.299 0.097 0.426

LeuLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.257 0.601 1.158 0.050 0.000 -0.151 1.187 0.233 0.217

psi2 0.010 0.001 -0.364 0.023 0.048 0.217 0.264 0.013 0.052

psi3 0.063 0.023 -0.731 0.068 -0.396 0.041 0.101 0.000 0.036

psi4 0.098 -0.408 -0.752 -0.248 0.026 0.000 0.048 0.231 0.053

psi5 -0.037 0.458 -5.209 -0.122 0.001 -0.163 2.128 0.831 0.023

psi6 0.200 1.552 0.496 0.001 0.010 1.111 1.267 0.046 0.008

psi7 0.233 -0.438 0.055 -0.646 0.038 -0.043 0.184 0.099 0.059

psi8 -0.930 -2.842 -0.846 -0.393 0.069 0.018 0.340 0.075 0.130

psi9 1.757 -1.844 2.269 1.278 0.019 0.038 0.450 0.188 0.237

Leule

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.251 0.243 0.378 0.019 0.024 0.037 0.290 0.009 0.054

psi2 0.079 0.096 0.061 0.024 0.008 0.300 0.514 0.031 -0.029

psi3 0.155 -0.328 0.277 0.512 0.021 0.062 0.415 -0.159 0.007

psi4 0.529 -0.525 2.708 0.853 0.027 0.079 0.790 0.364 0.151

psi5 0.388 1.491 2.188 0.392 0.010 -0.064 3.172 0.410 0.046

psi6 0.613 0.640 0.976 0.230 0.026 3.636 2.182 -0.046 0.055

psi7 -0.420 1.443 1.378 -0.212 0.066 0.563 0.256 0.024 0.005

psi8 -0.638 0.184 -0.412 2.422 0.034 0.066 0.083 0.003 0.157

psi9 2.102 0.608 0.579 1.739 0.000 0.000 0.046 0.007 0.063

TrpHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.012 0.001 0.001 0.000 0.000 0.001 0.067 0.000 0.000

psi2 0.001 0.001 0.004 0.000 0.000 0.004 0.001 0.000 0.000

psi3 0.002 0.008 -2.058 -0.359 0.008 0.000 0.000 0.000 0.000

psi4 0.003 0.351 -3.358 -1.818 0.000 0.000 0.000 0.001 0.000

psi5 0.006 0.133 0.347 0.055 0.000 0.000 0.004 0.003 0.000

psi6 0.001 -0.377 0.026 0.001 0.000 -0.019 0.010 0.000 0.000

psi7 -0.359 0.020 0.015 0.000 0.000 0.000 0.063 0.000 0.000

psi8 0.002 0.029 0.065 0.022 0.000 0.000 0.000 0.012 0.000

psi9 -0.161 -0.070 -1.009 0.006 0.000 0.000 0.055 0.002 0.000

TrpHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.013 0.007 0.020 0.000 0.000 0.001 0.034 0.003 0.000

psi2 0.000 0.001 0.002 0.000 0.000 0.009 0.011 0.000 0.000

psi3 0.000 0.009 -0.017 -0.131 0.001 0.000 0.001 0.000 0.000

psi4 0.000 -0.227 -0.607 0.216 0.009 0.000 0.000 0.000 0.001

psi5 0.001 -0.229 -2.023 0.075 0.000 0.000 0.027 0.002 0.000

psi6 0.005 -0.091 0.056 0.000 0.000 0.037 0.016 0.000 0.000

psi7 0.020 -0.071 0.043 0.003 0.000 0.008 0.001 0.000 0.000

psi8 0.007 0.089 0.072 0.067 0.000 0.000 0.000 0.000 0.000

psi9 0.059 0.067 0.241 0.016 0.000 0.000 0.038 0.002 0.000

TrpHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.004 0.000 0.000 0.001 0.001 0.000 0.000

psi2 0.000 0.002 0.000 0.000 0.031 0.006 0.002 0.000 0.000

psi3 0.013 0.003 0.133 0.159 0.006 0.000 0.000 0.000 0.001

psi4 0.021 0.073 4.029 0.914 -0.419 0.000 0.001 0.000 0.000

psi5 0.011 -0.482 0.746 0.177 0.000 0.000 0.040 0.004 0.001

psi6 0.037 0.054 0.028 0.000 0.000 0.238 0.070 0.001 0.000

psi7 0.001 -0.241 0.005 0.000 0.000 0.006 0.000 0.000 0.000

psi8 0.001 0.002 0.040 0.010 0.000 0.001 0.000 0.000 0.000

psi9 0.003 0.004 0.279 0.022 0.000 0.000 0.054 0.000 0.000

TrpSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.094 0.042 0.020 0.000 0.000 0.000 0.004 0.062 0.034

psi2 0.000 0.006 0.000 -0.198 0.000 0.000 0.000 0.002 0.002

psi3 0.000 0.004 0.002 0.004 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.001 0.073 0.068 0.000 0.000 0.001 0.000 0.000

psi5 0.000 0.041 0.015 0.056 0.000 0.000 0.056 0.000 0.000

psi6 0.010 0.004 0.028 0.000 0.000 0.247 0.000 0.000 0.000

psi7 0.007 -0.161 0.016 0.000 0.000 0.004 0.000 0.000 0.000

psi8 -0.213 1.587 -0.528 0.040 0.000 0.000 0.000 0.000 0.000

psi9 -2.104 -2.983 -2.701 0.029 0.000 0.000 0.000 0.011 0.019

TrpSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.060 -0.310 0.065 0.000 0.000 0.000 0.022 0.134 0.088

psi2 0.017 0.005 0.000 0.000 0.000 0.000 0.005 0.000 0.003

psi3 0.000 0.001 0.032 0.005 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.027 0.197 0.028 0.000 0.000 0.000 0.001 0.000

psi5 0.000 0.072 0.191 0.002 0.000 0.000 0.006 0.001 0.000

psi6 0.001 0.013 0.010 0.000 0.000 0.016 0.005 0.000 0.000

psi7 0.045 0.017 0.124 0.000 0.000 0.000 0.004 0.000 0.029

psi8 0.603 -0.692 -3.392 0.410 0.001 0.000 0.000 0.001 0.082

psi9 -2.980 -3.852 -0.106 0.168 0.000 0.000 0.022 0.016 0.051

TrpSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.048 0.013 0.002 0.000 0.000 0.000 0.001 0.000 0.094

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.001 0.000 0.000

psi3 0.000 0.001 0.001 0.048 0.000 0.000 0.000 0.001 0.000

psi4 0.000 0.015 -0.046 0.067 0.001 0.000 0.047 0.000 0.000

psi5 0.010 0.017 -0.122 0.090 0.000 0.001 0.008 0.002 0.000

psi6 0.001 0.016 0.001 0.001 0.000 0.017 0.013 0.000 0.000

psi7 0.015 0.025 -0.033 0.000 0.000 0.000 0.000 0.000 0.010

psi8 -0.305 1.063 0.413 0.048 0.000 0.000 0.001 0.000 0.010

psi9 -0.426 0.858 0.157 0.101 0.000 0.000 0.001 0.000 0.000

TrpLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.047 0.168 0.123 0.002 0.000 0.008 0.029 0.016 0.009

psi2 0.005 0.015 0.001 0.000 0.034 -0.064 0.013 0.001 0.001

psi3 0.003 0.041 0.075 -0.010 0.000 0.004 0.001 0.010 0.000

psi4 -0.041 0.066 0.117 -0.090 0.000 0.000 0.082 0.019 0.006

psi5 0.020 -0.627 0.032 -0.028 0.000 0.001 0.117 0.040 0.000

psi6 0.278 0.036 0.088 0.006 0.000 -0.157 -0.844 0.001 0.000

psi7 0.202 -0.323 -0.431 0.012 0.004 0.011 0.003 0.001 0.000

psi8 0.340 -0.591 -0.247 -0.530 0.000 0.005 0.003 0.005 0.011

psi9 -1.384 -0.722 0.753 0.343 0.000 0.000 0.052 0.022 0.089

TrpLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.336 0.258 0.203 0.009 0.000 0.008 0.165 0.107 0.229

psi2 0.007 0.020 0.048 0.005 0.000 0.027 0.032 0.005 0.005

psi3 0.018 0.028 0.044 -0.160 0.011 0.001 0.009 0.000 0.010

psi4 0.014 0.095 0.821 -0.476 0.006 0.000 0.045 0.056 0.003

psi5 0.028 -0.269 0.249 0.109 0.000 0.010 -0.039 0.062 0.006

psi6 -0.385 0.326 0.123 0.000 0.000 1.211 -0.103 0.002 0.001

psi7 -0.009 -0.458 0.529 0.028 0.010 -0.061 0.017 0.011 0.012

psi8 -0.227 0.927 -0.509 0.394 0.012 0.004 0.026 0.039 0.127

psi9 0.566 0.463 0.016 0.199 0.005 0.010 0.146 0.032 0.166

TrpLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.015 0.124 0.051 0.000 0.008 0.006 0.025 0.003 0.014

psi2 0.017 0.031 0.024 0.006 0.001 0.064 0.065 0.003 0.010

psi3 0.024 0.054 0.418 0.228 0.005 0.007 0.021 0.026 0.001

psi4 0.039 -0.036 1.456 0.882 0.009 0.014 0.131 0.048 0.009

psi5 -0.068 0.446 1.299 0.148 0.005 0.059 1.549 0.101 0.022

psi6 0.097 0.199 0.261 0.046 0.003 0.196 0.723 0.005 0.010

psi7 0.046 -0.303 0.284 0.044 0.013 0.172 0.049 0.010 0.001

psi8 0.182 0.638 1.205 -0.054 0.007 0.003 0.027 0.001 0.031

psi9 0.145 0.666 1.610 0.107 0.000 0.000 0.009 0.001 0.013

ValHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.008 0.019 0.118 0.000 0.000 0.005 0.019 0.001 0.000

psi2 0.004 0.002 0.026 0.000 0.000 0.021 0.006 0.000 0.000

psi3 0.007 -0.110 -0.110 -0.952 0.017 0.000 0.000 0.000 0.000

psi4 0.126 0.015 -6.824 -0.673 0.000 0.000 0.000 0.003 0.000

psi5 0.023 -0.265 1.641 -0.501 0.000 0.000 0.013 0.014 0.000

psi6 0.010 0.231 0.176 0.010 0.000 0.045 0.378 0.000 0.000

psi7 0.018 -0.011 0.020 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.041 -0.721 -0.012 0.104 0.000 0.000 0.004 0.006 0.000

psi9 0.410 -0.109 0.254 -0.231 0.000 0.000 0.007 0.008 0.000

ValHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.012 0.021 0.051 0.000 0.000 0.003 0.049 0.010 0.000

psi2 0.000 0.067 0.011 0.000 0.000 0.048 0.012 0.000 0.000

psi3 0.002 0.127 -1.008 0.259 0.004 0.000 0.001 0.000 0.000

psi4 0.000 -0.324 -4.525 2.931 0.052 0.000 0.001 0.000 0.109

psi5 0.003 1.506 1.206 -2.094 0.000 0.211 0.155 0.069 0.050

psi6 0.020 -0.190 0.304 0.000 0.000 0.220 0.020 0.000 0.000

psi7 0.216 -0.104 0.242 0.019 0.000 0.027 0.002 0.000 0.000

psi8 0.525 -0.808 -0.634 0.094 0.000 0.000 0.001 0.001 0.000

psi9 0.156 0.122 1.344 0.124 0.000 0.000 0.072 0.017 0.001

ValHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.099 0.003 0.008 0.000 0.000 0.004 0.005 0.000 0.000

psi2 0.000 0.012 0.000 0.000 0.111 0.030 0.010 0.000 0.000

psi3 0.018 0.012 1.420 0.675 0.216 0.001 0.001 0.000 0.003

psi4 0.074 0.291 5.958 1.058 0.146 0.000 0.002 0.000 0.000

psi5 0.036 0.742 4.641 0.539 0.000 0.003 0.268 0.010 0.004

psi6 0.027 0.197 0.062 0.000 0.000 0.125 0.262 0.003 0.000

psi7 0.021 0.038 0.017 0.000 0.000 0.022 0.000 0.000 0.000

psi8 0.004 0.057 -0.023 0.039 0.000 0.004 0.000 0.000 0.000

psi9 -0.096 -0.037 0.410 0.138 0.000 0.000 0.004 0.000 0.000

ValSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.368 0.227 0.115 0.000 0.000 0.000 0.086 0.036 0.480

psi2 0.000 0.017 0.000 0.017 0.000 0.001 0.001 0.004 0.010

psi3 0.000 0.019 0.130 0.039 0.000 0.000 0.001 0.000 0.000

psi4 0.000 -0.676 -0.219 0.254 0.000 0.000 0.013 0.000 0.000

psi5 0.001 -1.380 -0.187 -0.388 0.000 0.000 0.050 0.001 0.000

psi6 0.042 0.022 0.025 0.001 0.000 0.008 0.001 0.000 0.000

psi7 0.078 -0.302 0.081 0.000 0.000 0.007 0.000 0.000 0.000

psi8 -0.877 -10.491 -2.625 0.304 0.000 0.000 0.000 0.000 0.001

psi9 0.492 -6.399 1.481 -0.270 0.000 0.000 0.001 0.255 0.076

ValSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.535 -1.159 0.407 0.000 0.000 0.000 0.069 0.062 0.574

psi2 0.143 0.031 0.000 0.000 0.000 0.000 0.033 0.000 0.012

psi3 0.000 -0.072 0.038 0.089 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.489 0.137 0.116 0.000 0.000 0.000 0.012 0.000

psi5 0.000 -2.826 -0.126 0.014 0.000 0.000 0.056 0.084 0.000

psi6 0.013 0.053 0.042 0.000 0.000 0.018 0.120 0.000 0.000

psi7 -0.362 -0.670 -0.009 0.000 0.000 0.000 0.018 0.000 0.184

psi8 -1.469 -12.033 -5.357 -0.016 0.004 0.000 0.000 0.055 -0.170

psi9 3.934 -6.111 1.278 0.292 0.000 0.000 0.112 0.249 0.150

ValSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.199 0.074 0.005 0.000 0.000 0.000 0.003 0.000 0.013

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.013 0.000 0.000

psi3 0.000 0.008 0.055 0.062 0.000 0.000 0.000 0.012 0.000

psi4 0.000 -0.419 0.721 0.347 -0.100 0.000 0.027 0.000 0.000

psi5 0.041 0.175 0.205 0.080 0.000 0.003 0.056 0.025 0.000

psi6 0.004 0.045 0.013 0.013 0.000 0.114 0.056 0.000 0.000

psi7 0.104 0.238 0.084 0.000 0.000 0.100 0.000 0.000 0.065

psi8 -0.963 -3.575 -0.654 0.236 0.000 0.000 0.013 0.000 -0.364

psi9 -0.479 0.176 -0.379 0.353 0.000 0.000 0.013 0.000 0.001

ValLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.264 0.024 0.362 0.010 0.000 0.093 0.117 0.058 0.029

psi2 0.062 0.080 0.005 0.001 0.065 0.043 0.031 0.002 0.004

psi3 0.006 -0.238 -0.108 0.038 0.000 -0.222 0.004 0.042 0.000

psi4 0.014 -1.054 -1.129 0.777 0.000 0.001 0.054 0.412 0.014

psi5 -0.053 -0.354 1.199 -0.286 0.000 0.003 0.395 0.342 0.025

psi6 0.061 0.520 0.356 0.017 0.000 0.367 0.219 0.004 0.000

psi7 0.251 0.112 -0.736 0.035 -0.221 0.037 0.009 0.002 0.000

psi8 -1.543 -7.596 -4.847 -1.187 0.000 0.038 -0.166 0.221 0.056

psi9 1.025 -1.662 2.412 -0.490 0.000 0.000 0.084 0.180 0.193

ValLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.872 1.700 0.862 0.036 0.000 0.027 0.297 0.216 0.423

psi2 0.007 0.123 0.150 0.018 0.002 0.108 0.103 0.030 0.044

psi3 -0.042 0.286 -0.027 0.221 0.027 0.024 0.187 0.000 0.048

psi4 0.075 -0.303 -0.314 -0.779 0.020 0.000 0.186 0.163 0.023

psi5 0.178 1.555 3.176 -0.210 0.038 0.034 1.939 0.416 0.020

psi6 0.289 0.652 0.490 0.001 0.006 -0.494 0.988 0.046 0.005

psi7 0.450 0.583 1.579 0.106 0.026 0.303 0.106 0.047 0.048

psi8 -0.780 -3.464 -3.516 0.878 0.022 0.018 0.001 0.041 0.116

psi9 0.054 -1.257 5.826 1.674 0.015 0.035 0.037 0.206 -0.019

ValLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.185 0.762 0.268 0.001 0.016 0.264 0.343 0.007 -0.154

psi2 0.304 0.442 0.111 0.019 0.006 0.458 0.388 0.029 0.048

psi3 0.115 -0.315 0.132 0.255 0.036 0.023 0.120 -0.330 0.004

psi4 0.038 -0.323 0.878 3.336 0.024 0.059 0.511 0.207 -0.070

psi5 0.212 0.993 4.003 0.291 0.028 0.323 3.508 0.462 0.009

psi6 0.277 0.919 0.895 0.158 0.011 2.801 2.199 0.157 0.051

psi7 0.306 -0.774 1.675 0.242 0.032 0.312 0.198 0.029 0.004

psi8 0.292 -1.860 -3.518 -0.740 0.039 0.020 -0.001 0.003 0.134

psi9 0.186 0.871 3.850 0.779 0.000 0.000 0.080 0.148 0.186

IleHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.015 0.004 0.004 0.000 0.000 0.005 0.024 0.000 0.000

psi2 0.003 0.002 0.018 0.000 0.000 0.010 0.005 0.000 0.000

psi3 0.004 -0.059 -0.491 0.062 0.048 0.000 0.000 0.000 0.000

psi4 0.012 -0.931 -5.057 -5.625 0.000 0.000 0.000 0.003 0.000

psi5 0.023 -0.805 -0.198 -0.453 0.000 0.000 0.129 0.007 0.000

psi6 0.005 -0.481 0.136 0.006 0.000 0.017 0.024 0.000 0.000

psi7 -0.066 -0.070 -0.161 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.012 -0.275 -0.777 -0.124 0.000 0.000 0.002 0.014 0.000

psi9 0.030 0.084 0.420 0.018 0.000 0.000 0.132 0.006 0.000

IleHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.018 0.125 0.034 0.000 0.000 0.004 0.305 0.010 0.000

psi2 0.000 0.001 0.050 0.000 0.000 0.021 0.006 0.000 0.000

psi3 0.001 0.031 0.140 0.857 0.006 0.000 0.001 0.000 0.000

psi4 0.000 -0.833 -3.462 -0.550 -0.555 0.000 0.001 0.000 0.011

psi5 0.002 1.008 2.350 -2.466 0.000 0.001 0.082 0.021 0.000

psi6 0.059 0.156 0.235 0.000 0.000 0.118 0.047 0.000 0.000

psi7 0.242 0.157 0.228 0.011 0.000 0.023 0.002 0.000 0.000

psi8 0.059 -0.242 0.172 0.110 0.000 0.000 0.001 0.001 0.000

psi9 0.216 0.487 0.352 0.059 0.000 0.000 0.073 0.006 0.001

IleHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.002 0.036 0.000 0.000 0.002 0.005 0.000 0.000

psi2 0.000 0.007 0.000 0.000 0.070 0.037 0.013 0.000 0.000

psi3 0.019 0.017 0.360 -1.373 0.337 0.001 0.001 0.000 0.003

psi4 0.046 -0.132 3.632 3.216 0.024 0.000 0.002 0.000 0.000

psi5 0.025 1.013 -0.497 0.695 0.000 0.002 0.143 0.008 0.003

psi6 0.025 0.025 0.061 0.000 0.000 0.233 0.138 0.002 0.000

psi7 0.015 0.061 0.013 0.000 0.000 0.013 0.000 0.000 0.000

psi8 0.002 0.370 0.055 0.029 0.000 0.003 0.000 0.000 0.000

psi9 0.006 0.072 0.319 0.177 0.000 0.000 0.003 0.000 0.000

IleSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.456 0.025 0.049 0.000 0.000 0.000 0.010 0.234 0.582

psi2 0.000 0.010 0.000 0.009 0.000 0.001 0.001 0.129 0.004

psi3 0.000 -0.220 -0.039 0.084 0.000 0.000 0.001 0.000 0.000

psi4 0.000 -0.268 -0.096 0.124 0.000 0.000 0.004 0.000 0.000

psi5 0.001 -0.553 -0.193 0.024 0.000 0.000 0.025 0.004 0.000

psi6 0.025 0.012 0.007 0.001 0.000 0.005 0.001 0.000 0.000

psi7 0.122 -0.699 -0.026 0.000 0.000 0.004 0.000 0.000 0.000

psi8 -0.643 -11.510 -5.699 0.023 0.000 0.000 0.000 0.000 0.001

psi9 1.293 -2.382 1.357 -0.055 0.000 0.000 0.000 0.135 0.074

IleSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.818 -0.065 0.128 0.000 0.000 0.000 0.060 0.072 0.313

psi2 0.048 0.022 0.000 0.000 0.000 0.000 0.015 0.000 0.008

psi3 0.000 -0.049 -0.161 0.070 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.279 0.018 0.391 0.000 0.000 0.000 0.004 0.000

psi5 0.000 -0.689 0.240 0.005 0.000 0.000 0.022 0.005 0.000

psi6 0.004 -0.393 0.025 0.000 0.000 0.023 0.059 0.000 0.000

psi7 0.172 0.362 -0.143 0.000 0.000 0.000 0.019 0.000 0.115

psi8 2.043 -11.896 -3.207 -0.160 -0.093 0.000 0.000 0.004 0.178

psi9 2.993 -0.971 1.987 0.266 0.000 0.000 0.058 0.052 0.145

IleSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.073 0.052 0.002 0.000 0.000 0.000 0.003 0.009 0.043

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.004 0.000 0.000

psi3 0.000 0.003 0.004 0.019 0.000 0.000 0.000 0.003 0.000

psi4 0.000 0.490 0.141 0.194 0.043 0.000 0.023 0.000 0.000

psi5 0.024 -0.055 0.170 0.011 0.000 0.003 0.026 0.008 0.000

psi6 0.004 0.058 0.004 0.004 0.000 0.217 0.033 0.000 0.000

psi7 0.079 -0.398 -0.022 0.000 0.000 0.000 0.000 0.000 0.024

psi8 0.416 -1.012 -2.191 0.079 0.000 0.000 0.004 0.000 0.049

psi9 0.560 1.251 0.249 0.183 0.000 0.000 0.004 0.000 0.001

IleLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.405 0.165 0.408 0.009 0.071 0.021 0.201 0.108 0.049

psi2 -0.084 0.050 0.004 0.001 0.033 0.064 -0.100 0.002 0.002

psi3 0.081 -0.069 0.068 0.128 0.000 0.019 0.004 0.049 0.000

psi4 0.008 -2.413 0.494 0.315 0.000 0.001 -0.236 0.157 0.010

psi5 0.252 -0.680 0.430 -0.175 0.000 0.003 0.697 0.276 0.001

psi6 0.065 0.869 0.215 0.009 0.000 0.334 0.332 0.004 0.000

psi7 -0.057 -2.412 -1.431 0.020 0.050 0.029 0.141 0.002 0.000

psi8 0.497 -8.923 -5.889 0.096 0.000 0.032 -0.076 0.025 0.057

psi9 1.432 -1.980 1.811 0.629 0.000 0.000 0.073 0.047 0.174

IleLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.232 0.244 1.317 0.026 0.000 0.061 0.324 0.243 0.285

psi2 0.007 -0.018 0.150 0.007 0.001 0.065 0.071 0.009 0.004

psi3 -0.385 -0.359 0.155 0.261 0.027 -0.168 0.053 0.000 0.048

psi4 -0.003 -1.366 1.621 -0.184 0.129 0.000 0.122 0.114 0.018

psi5 0.088 0.924 2.571 -0.245 0.000 0.019 1.772 0.223 0.010

psi6 0.153 1.167 0.623 0.001 0.006 1.273 1.158 0.114 0.005

psi7 0.433 1.238 0.352 0.010 0.017 0.151 0.102 0.013 0.031

psi8 0.842 -6.011 -5.795 2.126 0.013 0.021 -0.137 0.038 0.070

psi9 2.750 -2.578 7.075 1.023 0.005 0.028 0.276 0.249 -0.694

IleLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.132 -0.152 0.309 0.001 0.138 0.050 0.112 0.008 0.027

psi2 0.082 0.136 0.076 0.012 0.096 0.220 0.125 0.020 0.032

psi3 0.089 -0.169 0.382 0.368 0.006 0.015 -0.175 0.023 0.004

psi4 0.178 0.527 2.767 0.936 0.016 0.094 0.257 0.247 0.117

psi5 0.312 0.789 3.611 0.412 0.007 0.184 2.547 0.344 0.008

psi6 0.239 1.325 0.599 0.116 0.114 3.284 1.787 0.018 -0.218

psi7 0.176 1.374 1.741 0.047 0.063 0.288 0.017 0.012 0.052

psi8 -0.431 -1.668 0.182 1.526 0.027 0.020 -0.143 0.002 0.092

psi9 0.564 0.274 2.837 1.130 0.000 0.000 0.105 0.010 0.043

MetHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.005 0.001 0.001 0.000 0.000 0.002 0.009 0.000 0.000

psi2 0.002 0.000 0.015 0.000 0.000 0.004 0.003 0.000 0.000

psi3 0.002 0.015 0.174 0.181 0.016 0.000 0.000 0.000 0.000

psi4 0.007 0.022 -3.583 -0.382 0.000 0.000 0.000 0.001 0.000

psi5 0.008 -0.433 -0.771 0.064 0.000 0.000 0.004 0.003 0.000

psi6 0.001 -0.273 0.026 0.003 0.000 0.006 0.015 0.000 0.000

psi7 -0.141 0.024 0.021 0.000 0.000 0.000 0.000 0.000 0.000

psi8 0.007 -0.054 -0.005 0.032 0.000 0.000 0.001 0.005 0.000

psi9 0.008 0.064 0.097 0.006 0.000 0.000 0.004 0.003 0.000

Methm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.006 0.010 0.017 0.000 0.000 0.002 0.023 0.007 0.000

psi2 0.000 0.043 0.003 0.000 0.000 0.013 0.008 0.000 0.000

psi3 0.001 -0.367 0.625 1.070 0.002 0.000 0.000 0.000 0.000

psi4 0.000 0.250 -6.265 1.087 0.011 0.000 0.000 0.000 0.004

psi5 0.001 0.339 -1.902 0.093 0.000 0.000 0.021 0.002 0.000

psi6 0.114 0.125 0.129 0.000 0.000 0.039 0.006 0.000 0.000

psi7 0.095 0.039 0.051 0.004 0.000 0.048 0.001 0.000 0.000

psi8 0.065 0.084 0.174 0.064 0.000 0.000 0.000 0.000 0.000

psi9 0.064 0.095 0.723 -0.047 0.000 0.000 0.043 0.003 0.000

Methe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.001 0.000 0.000 0.003 0.002 0.000 0.000

psi2 0.000 0.003 0.000 0.000 0.031 0.010 0.005 0.000 0.000

psi3 -0.078 0.009 0.151 0.423 0.012 0.001 0.000 0.000 0.001

psi4 0.017 0.108 3.907 2.777 0.006 0.000 0.001 0.000 0.000

psi5 0.016 0.103 1.286 0.112 0.000 0.001 0.097 0.005 0.002

psi6 0.014 0.099 0.030 0.000 0.000 0.045 0.050 0.001 0.000

psi7 0.024 0.020 0.019 0.000 0.000 0.011 0.000 0.000 0.000

psi8 0.003 0.005 0.032 -0.082 0.000 0.002 0.000 0.000 0.000

psi9 0.002 0.002 0.178 0.022 0.000 0.000 0.001 0.000 0.000

Metsb

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.072 0.102 -0.024 0.000 0.000 0.000 0.003 0.065 0.208

psi2 0.000 0.004 0.000 0.004 0.000 0.000 0.000 0.001 0.003

psi3 0.000 0.003 0.119 0.006 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.080 -0.279 0.107 0.000 0.000 0.002 0.000 0.000

psi5 0.000 0.034 0.011 0.006 0.000 0.000 0.006 0.001 0.000

psi6 0.006 0.002 0.006 0.000 0.000 0.003 0.000 0.000 0.000

psi7 -0.025 -0.085 0.036 0.000 0.000 0.002 0.000 0.000 0.000

psi8 -0.861 2.868 -0.616 0.080 0.000 0.000 0.000 0.000 0.000

psi9 -1.330 -1.545 0.053 0.031 0.000 0.000 0.000 0.003 0.025

MetSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.140 0.018 0.059 0.000 0.000 0.000 0.076 0.015 0.132

psi2 0.017 0.004 0.000 0.000 0.000 0.000 0.004 0.000 0.002

psi3 0.000 0.003 0.010 0.008 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.045 -0.117 0.230 0.000 0.000 0.000 0.002 0.000

psi5 0.000 0.066 0.148 0.002 0.000 0.000 0.008 0.002 0.000

psi6 0.002 0.009 0.006 0.000 0.000 0.008 0.009 0.000 0.000

psi7 0.031 -0.092 0.080 0.000 0.000 0.000 0.002 0.000 0.089

psi8 0.405 -1.432 -1.559 0.199 0.002 0.000 0.000 0.002 0.026

psi9 -0.629 -1.289 0.410 0.037 0.000 0.000 0.012 0.040 0.017

MetSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.021 0.046 0.002 0.000 0.000 0.000 0.001 0.000 0.002

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.002 0.000 0.000

psi3 0.000 0.002 0.002 0.082 0.000 0.000 0.000 0.002 0.000

psi4 0.000 0.015 0.052 0.109 0.002 0.000 0.004 0.000 0.000

psi5 0.006 0.026 0.037 0.005 0.000 0.001 0.017 0.003 0.000

psi6 0.001 0.010 0.002 0.002 0.000 0.018 0.012 0.000 0.000

psi7 0.013 0.024 0.022 0.000 0.000 0.000 0.000 0.000 0.006

psi8 0.201 0.005 0.678 0.094 0.000 0.000 0.002 0.000 0.006

psi9 0.308 0.456 0.750 0.135 0.000 0.000 0.002 0.000 0.000

MetLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.006 -0.244 0.099 0.007 0.000 0.009 0.084 0.012 0.009

psi2 0.005 0.019 0.001 0.000 0.006 0.155 0.013 0.001 0.001

psi3 0.003 0.025 0.041 0.014 0.000 0.002 0.002 0.006 0.000

psi4 0.003 0.121 0.276 -0.223 0.000 0.000 0.015 0.019 0.004

psi5 0.021 -0.338 0.203 0.025 0.000 0.083 0.377 0.171 0.000

psi6 0.051 -1.072 -0.846 0.004 0.000 -0.011 0.191 0.002 0.000

psi7 0.322 -0.186 -0.170 0.008 0.003 -0.139 0.003 0.001 0.000

psi8 -0.479 0.430 0.667 -0.548 0.000 0.008 0.008 0.045 0.016

psi9 -0.317 0.043 -1.659 0.177 0.000 0.000 0.141 0.020 0.038

Metlm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.099 0.206 0.222 0.007 0.000 0.007 0.093 0.055 0.046

psi2 0.003 0.035 0.045 0.003 0.000 0.021 0.393 0.008 0.017

psi3 0.016 -0.051 -0.040 0.057 0.007 0.008 0.025 0.000 0.052

psi4 -0.081 0.096 0.369 0.070 0.005 0.000 0.051 0.054 0.010

psi5 0.035 0.847 0.541 -0.017 0.000 0.007 0.859 0.080 0.004

psi6 0.008 0.087 -0.162 0.000 0.002 -0.470 -0.613 0.007 0.002

psi7 -0.133 -0.729 0.597 0.022 0.009 0.066 0.034 0.006 0.017

psi8 0.382 -0.853 -1.293 0.026 0.006 0.002 0.034 0.033 0.041

psi9 0.410 1.554 1.104 -0.116 0.002 0.006 0.131 0.247 0.058

Metle

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.160 0.104 0.070 0.000 -2.068 0.011 0.048 0.003 0.011

psi2 -0.384 0.018 0.022 -0.200 0.001 0.206 0.060 0.007 0.009

psi3 0.033 0.078 0.090 0.094 0.002 0.006 0.117 0.014 0.002

psi4 0.039 -0.323 2.718 0.815 0.010 0.009 0.261 0.065 0.010

psi5 0.054 0.667 1.244 -0.362 0.007 0.073 1.402 0.096 0.002

psi6 0.080 0.937 -0.520 0.046 0.002 1.254 0.918 0.008 0.009

psi7 -0.002 -0.150 0.233 0.070 0.022 0.176 -0.038 0.005 0.001

psi8 -0.200 0.094 1.862 0.428 0.010 0.006 0.026 0.092 0.027

psi9 0.380 -2.662 1.817 0.649 0.000 0.000 0.012 0.002 0.024

HisHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.011 0.001 0.001 0.000 0.000 0.001 0.016 0.000 0.000

psi2 0.001 0.000 0.010 0.000 0.000 0.004 0.001 0.000 0.000

psi3 0.001 0.012 0.178 0.102 0.016 0.000 0.000 0.000 0.000

psi4 0.006 -0.128 6.603 4.269 0.000 0.000 0.000 0.001 0.000

psi5 0.005 -1.335 0.608 -0.203 0.000 0.000 0.004 0.005 0.000

psi6 0.003 0.328 0.035 0.001 0.000 0.006 0.006 0.000 0.000

psi7 0.016 0.025 0.438 0.000 0.000 0.000 0.000 0.000 0.000

psi8 0.008 -0.015 0.044 0.127 0.000 0.000 0.002 0.010 0.000

psi9 0.009 0.012 -0.438 0.025 0.000 0.000 0.002 0.003 0.000

HisHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.013 0.132 0.154 0.000 0.000 0.003 0.025 0.002 0.000

psi2 0.000 0.001 0.002 0.000 0.000 0.019 0.019 0.000 0.000

psi3 0.000 0.013 -0.272 0.559 0.002 0.000 0.000 0.000 0.000

psi4 -0.068 0.085 -1.134 -0.073 0.027 0.000 0.000 0.000 0.005

psi5 -0.168 -3.988 -0.247 0.542 0.000 0.046 0.027 0.002 0.000

psi6 0.007 -0.182 0.200 0.000 0.000 -0.181 0.006 0.000 0.000

psi7 0.026 -0.887 0.198 0.007 0.000 0.009 0.001 0.000 0.000

psi8 -0.107 0.047 -1.557 -0.070 0.000 0.000 0.000 0.011 0.000

psi9 -0.718 0.117 0.405 -0.089 0.000 0.000 0.056 0.006 0.000

HisHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.001 0.001 0.000 0.000 0.002 0.002 0.000 0.000

psi2 0.000 0.002 0.000 0.000 0.010 -0.064 0.004 0.000 0.000

psi3 0.004 0.008 -1.584 0.608 0.023 0.001 0.000 0.000 0.001

psi4 0.053 -0.176 1.834 -1.576 0.010 0.000 0.001 0.000 0.000

psi5 0.016 -1.328 -0.748 0.136 0.000 0.002 0.042 0.005 0.006

psi6 0.004 -1.214 0.140 0.000 0.000 -0.021 -0.059 0.001 0.000

psi7 0.003 -0.553 0.009 0.000 0.000 0.010 0.000 0.000 0.000

psi8 0.002 -0.009 0.033 0.016 0.000 0.001 0.000 0.000 0.000

psi9 0.043 -0.075 -1.138 0.040 0.000 0.000 0.001 0.000 0.000

HisSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.123 0.083 0.018 0.000 0.000 0.000 0.004 0.083 0.104

psi2 0.000 0.006 0.000 0.006 0.000 0.000 0.000 0.001 0.002

psi3 0.000 0.009 0.004 0.043 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.198 0.110 0.193 0.000 0.000 0.004 0.000 0.000

psi5 0.000 0.204 0.031 0.010 0.000 0.000 0.010 0.000 0.000

psi6 0.010 0.028 0.012 0.000 0.000 0.003 0.000 0.000 0.000

psi7 0.011 0.114 -0.059 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.406 4.244 1.984 -0.068 0.000 0.000 0.000 0.000 0.000

psi9 -0.898 2.179 0.944 0.040 0.000 0.000 0.000 0.024 0.024

HisSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.620 0.268 0.074 0.000 0.000 0.000 0.111 0.111 0.127

psi2 0.011 -0.131 0.000 0.000 0.000 0.000 0.005 0.000 0.009

psi3 0.000 -0.025 0.013 0.014 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.138 -0.213 -0.072 0.000 0.000 0.000 0.003 0.000

psi5 0.000 0.102 0.035 0.004 0.000 0.000 0.017 0.004 0.000

psi6 0.018 0.013 0.010 0.000 0.000 0.123 0.015 0.000 0.000

psi7 -0.320 -0.046 -0.078 0.000 0.000 0.000 0.007 0.000 0.029

psi8 -1.034 -1.957 -0.288 0.187 0.001 0.000 0.000 0.004 0.040

psi9 -2.416 -0.920 0.133 0.050 0.000 0.000 0.021 0.040 -0.395

HisSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.021 0.021 0.002 0.000 0.000 0.000 0.001 0.000 0.004

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.004 0.000 0.000

psi3 0.000 0.003 0.004 0.032 0.000 0.000 0.000 0.003 0.000

psi4 0.000 0.014 0.246 0.093 0.004 0.000 0.008 0.000 0.000

psi5 0.010 -0.024 0.072 0.010 0.000 0.001 0.013 0.007 0.000

psi6 0.001 0.028 0.003 0.003 0.000 0.014 -0.111 0.000 0.000

psi7 0.055 -0.284 0.127 0.000 0.000 0.000 0.000 0.000 0.018

psi8 -0.419 0.257 -0.023 0.056 0.000 0.000 0.003 0.000 0.010

psi9 0.026 -0.533 -0.152 0.078 0.000 0.000 0.003 0.000 0.000

HisLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.202 0.000 0.143 0.002 0.000 0.009 0.040 0.013 0.012

psi2 0.003 -0.053 0.032 0.000 0.010 0.013 0.131 0.001 0.001

psi3 0.001 0.028 0.312 0.011 0.000 0.007 0.001 0.010 0.000

psi4 -0.019 -0.038 0.893 -0.085 0.000 0.000 0.017 0.014 0.006

psi5 0.052 0.387 0.013 0.047 0.000 0.001 0.364 0.070 0.000

psi6 -0.178 0.221 -0.365 0.006 0.000 -0.041 0.100 0.001 0.000

psi7 0.069 -0.026 0.307 0.012 0.007 0.029 -0.002 0.001 0.000

psi8 0.140 0.495 1.668 0.285 0.000 0.012 0.008 0.027 0.011

psi9 -0.126 0.227 2.616 0.217 0.000 0.000 0.164 0.152 -0.151

HisLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.192 -0.050 0.373 0.012 0.000 -0.123 0.297 0.096 0.101

psi2 0.002 0.175 0.049 0.005 0.000 0.034 0.032 0.013 0.004

psi3 0.021 0.059 -0.078 0.084 0.011 0.010 0.018 0.000 0.010

psi4 0.027 0.543 0.503 0.271 0.007 0.000 -0.142 0.049 0.058

psi5 0.045 -0.637 0.274 0.155 0.000 0.011 0.503 0.397 0.006

psi6 0.202 -1.611 0.302 0.000 0.004 -1.085 0.511 0.011 0.001

psi7 -0.147 -0.684 -0.521 0.034 0.123 -0.090 -0.018 0.010 0.021

psi8 -0.171 -0.990 1.222 -0.687 0.007 0.007 0.201 0.008 -0.624

psi9 -1.387 -4.116 1.792 0.463 0.004 0.013 0.067 0.301 -0.008

Hisle

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.386 -2.185 0.296 0.000 0.016 0.185 0.068 0.002 -0.021

psi2 0.031 0.053 0.031 0.007 -0.056 -0.092 0.295 0.005 0.015

psi3 0.038 0.099 0.098 0.116 0.004 0.008 0.036 0.312 0.001

psi4 0.020 0.094 0.023 0.298 0.012 0.020 0.208 0.233 0.016

psi5 0.007 0.000 0.359 0.382 0.012 0.049 1.226 0.106 -0.151

psi6 -0.082 -1.041 -0.325 0.090 0.002 -1.484 -1.274 0.007 0.015

psi7 -0.863 -2.661 -0.164 0.059 0.025 0.303 0.113 0.005 0.002

psi8 0.121 -1.329 -2.189 0.116 0.009 0.006 -0.216 0.001 0.027

psi9 -0.273 1.084 2.793 0.699 0.000 0.000 0.014 0.002 0.043

TyrHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.023 0.003 0.002 0.000 0.000 0.003 0.031 0.000 0.000

psi2 0.002 0.002 0.009 0.000 0.000 0.007 0.002 0.000 0.000

psi3 0.004 -0.022 0.006 0.268 0.009 0.000 0.000 0.000 0.000

psi4 -0.009 -0.361 -0.445 1.354 0.000 0.000 0.000 0.002 0.000

psi5 0.014 -1.097 -1.126 0.095 0.000 0.000 0.008 0.007 0.000

psi6 0.004 0.211 0.041 0.002 0.000 0.011 0.019 0.000 0.000

psi7 0.166 -0.410 0.033 0.000 0.000 0.000 0.000 0.000 0.000

psi8 0.014 -0.068 -0.080 0.119 0.000 0.000 0.002 0.022 0.000

psi9 0.022 0.023 0.125 -0.080 0.000 0.000 0.004 0.021 0.000

TyrHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.025 0.015 0.038 0.000 0.000 0.003 0.080 0.006 0.000

psi2 0.000 0.001 -0.018 0.000 0.000 0.066 0.024 0.000 0.000

psi3 0.001 0.188 0.149 -1.265 0.067 0.000 0.001 0.000 0.000

psi4 0.000 -0.227 -0.796 0.066 0.032 0.000 0.001 0.000 0.007

psi5 0.002 -2.861 -1.782 0.820 0.000 0.000 0.388 0.003 0.000

psi6 0.045 -0.377 0.311 0.000 0.000 0.027 0.029 0.000 0.000

psi7 0.069 -0.778 0.074 0.005 0.000 0.009 0.001 0.000 0.000

psi8 -0.044 -0.405 -0.330 -0.987 0.000 0.000 0.001 0.000 0.000

psi9 0.092 0.190 0.857 0.031 0.000 0.000 0.077 0.008 0.001

Tyrhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.003 0.006 0.000 0.000 0.002 0.003 0.000 0.000

psi2 0.000 0.003 0.000 0.000 0.073 0.022 0.007 0.000 0.000

psi3 0.009 0.009 0.186 0.316 0.006 0.002 0.000 0.000 0.001

psi4 0.030 -0.234 3.541 3.199 0.012 0.000 0.002 0.000 0.000

psi5 0.020 0.358 1.109 0.270 0.000 0.002 0.131 0.007 0.002

psi6 0.017 0.106 -0.314 0.000 0.000 0.203 0.193 0.001 0.000

psi7 -0.259 0.031 0.013 0.000 0.000 0.008 0.000 0.000 0.000

psi8 0.002 0.010 0.054 0.068 0.000 0.002 0.000 0.000 0.000

psi9 0.005 0.037 0.434 -0.199 0.000 0.000 0.001 0.000 0.000

TyrSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.115 0.205 0.041 0.000 0.000 0.000 0.082 0.041 0.252

psi2 0.000 0.013 0.000 0.012 0.000 0.000 0.001 0.003 0.223

psi3 0.000 0.014 0.006 0.012 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.359 0.095 -0.053 0.000 0.000 0.004 0.000 0.000

psi5 0.000 0.092 0.097 0.072 0.000 0.000 0.013 0.001 0.000

psi6 0.013 0.008 0.012 0.000 0.000 -0.132 0.000 0.000 0.000

psi7 0.020 0.087 0.313 0.000 0.000 0.008 0.000 0.000 0.000

psi8 -0.130 0.980 1.956 0.057 0.000 0.000 0.000 0.000 0.000

psi9 -1.816 -4.454 0.071 0.087 0.000 0.000 0.000 0.013 0.166

TyrSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.291 0.235 0.173 0.000 0.000 0.000 0.019 0.449 0.745

psi2 0.093 0.017 0.000 0.000 0.000 0.000 0.019 0.000 0.010

psi3 0.000 0.009 0.016 -0.007 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.226 0.019 -0.063 0.000 0.000 0.000 0.004 0.000

psi5 0.000 0.591 0.188 0.005 0.000 0.000 0.020 0.005 0.000

psi6 0.148 0.017 0.034 0.000 0.000 0.033 0.058 0.000 0.000

psi7 0.057 -0.614 0.441 0.000 0.000 0.000 0.014 0.000 0.069

psi8 -1.153 -3.176 -1.318 0.022 0.002 0.000 0.000 0.004 0.056

psi9 -5.049 -3.491 -1.940 0.233 0.000 0.000 0.035 0.122 0.093

TyrSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.032 0.019 0.003 0.000 0.000 0.000 0.002 0.000 0.004

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.004 0.000 0.000

psi3 0.000 0.000 -0.213 0.131 0.000 0.000 0.000 0.003 0.000

psi4 0.000 0.033 0.062 -0.224 0.004 0.000 0.022 0.000 0.000

psi5 0.012 0.032 -0.334 0.011 0.000 0.001 0.021 0.007 0.000

psi6 0.001 0.013 0.003 0.004 0.000 0.024 0.014 0.000 0.000

psi7 0.038 0.111 0.050 0.000 0.000 0.000 0.000 0.000 0.012

psi8 -1.192 -0.851 -0.955 -0.078 0.000 0.000 0.004 0.000 0.012

psi9 0.482 -0.888 -1.290 0.074 0.000 0.000 0.036 0.000 0.000

TyrLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.059 0.014 0.237 0.005 0.000 0.019 0.229 0.040 0.022

psi2 0.015 0.045 0.002 0.001 0.033 0.030 0.024 0.001 0.002

psi3 0.004 0.204 -0.012 -0.150 0.000 0.013 0.003 0.020 0.000

psi4 0.009 -0.169 -0.584 0.303 0.000 0.000 -0.244 0.068 0.006

psi5 -0.049 -0.316 0.891 0.031 0.000 0.002 0.672 0.118 0.001

psi6 0.031 0.129 -0.025 0.012 0.000 -0.030 -0.173 0.002 0.000

psi7 0.087 -1.083 0.343 0.026 0.013 -0.012 0.006 0.001 0.000

psi8 0.501 -0.570 -0.663 0.701 0.000 0.019 0.013 0.011 0.022

psi9 -0.900 -0.391 0.813 0.842 0.000 0.000 0.190 0.083 -0.092

TyrLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.242 0.242 1.255 0.020 0.000 0.019 0.214 0.148 0.113

psi2 0.004 0.052 0.074 0.007 0.001 0.133 0.043 0.006 0.005

psi3 0.027 -0.007 0.091 0.169 0.014 0.015 0.069 0.000 0.012

psi4 0.046 0.163 0.664 0.025 0.013 0.000 -0.693 0.098 0.013

psi5 0.061 -1.268 2.139 0.262 0.000 0.014 1.328 0.430 0.013

psi6 0.018 -0.519 -0.495 0.000 0.007 -1.311 0.403 0.012 0.002

psi7 0.097 -1.297 -1.069 0.072 0.026 0.493 0.109 0.017 0.034

psi8 -1.649 -1.940 -0.500 1.138 0.016 0.013 -0.235 0.020 0.077

psi9 -2.535 -4.830 1.552 -0.234 0.005 0.026 0.241 0.094 0.097

TyrLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.295 -1.457 0.155 0.001 0.008 0.234 0.105 0.006 0.049

psi2 0.035 -0.472 0.053 0.013 0.004 0.146 0.270 0.007 0.021

psi3 0.103 0.133 -0.018 0.148 0.006 0.015 0.236 0.027 0.003

psi4 0.516 0.586 1.867 1.638 0.012 0.017 0.210 0.091 0.021

psi5 -0.109 0.478 4.628 0.279 0.005 0.018 1.670 0.169 0.005

psi6 0.175 0.514 0.480 0.060 0.004 0.742 1.575 0.014 0.022

psi7 0.108 0.597 0.999 -1.000 0.020 0.163 0.104 0.008 0.003

psi8 0.283 0.779 1.579 0.697 0.020 0.011 0.012 0.001 0.054

psi9 -1.542 0.529 2.126 0.036 0.000 0.000 0.026 0.004 -0.407

AlaHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.011 0.006 0.006 0.000 0.000 -0.024 0.029 0.001 0.001

psi2 0.006 -0.018 0.023 0.000 0.001 0.016 0.007 0.001 0.000

psi3 0.011 0.046 -0.286 0.467 -2.236 0.000 0.000 0.000 0.000

psi4 -0.060 0.780 -0.834 -4.788 0.000 0.000 0.000 0.004 0.000

psi5 0.013 1.372 1.134 -1.821 0.000 0.000 0.069 0.020 0.000

psi6 0.007 0.255 -0.033 0.008 0.000 0.171 0.038 0.000 0.000

psi7 -0.260 0.058 -0.105 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.026 0.232 0.155 0.223 0.000 0.000 0.005 0.009 0.000

psi9 0.172 0.140 -0.133 0.124 0.000 0.000 0.010 0.009 0.000

AlaHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.016 -0.059 0.083 0.000 0.000 0.012 -0.040 0.012 0.000

psi2 0.000 0.003 0.009 0.000 0.000 0.046 0.081 0.000 0.000

psi3 -0.135 0.164 -0.394 1.367 -0.216 0.000 0.002 0.000 0.000

psi4 0.000 0.431 -2.617 -6.548 0.080 0.000 0.002 0.001 0.014

psi5 0.004 0.682 1.400 -1.896 0.000 0.005 0.117 0.009 0.001

psi6 0.019 0.199 -0.564 0.000 0.000 0.014 0.170 0.000 0.000

psi7 0.039 0.105 -1.318 0.014 0.000 -0.068 0.002 0.000 0.000

psi8 0.478 0.283 0.827 -0.239 0.000 0.000 0.001 0.001 0.000

psi9 0.053 0.059 -0.186 0.023 0.000 0.000 0.212 0.045 0.017

Alahe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.004 0.012 0.000 0.000 -0.042 0.007 0.000 0.000

psi2 0.000 0.009 0.000 0.000 -0.399 0.160 0.038 0.000 0.000

psi3 0.026 0.003 0.872 1.010 0.144 0.002 0.001 0.000 -0.251

psi4 -1.833 0.864 -7.664 -3.936 0.055 0.000 0.066 0.000 0.000

psi5 0.042 0.649 -4.089 0.533 0.000 0.005 0.142 0.016 0.006

psi6 0.034 0.162 -0.109 0.000 0.000 -0.611 0.146 0.004 0.000

psi7 -0.126 0.179 0.031 0.000 0.000 0.025 0.000 0.000 0.000

psi8 0.003 0.028 0.011 0.202 0.000 0.005 0.000 0.000 0.000

psi9 0.028 0.056 -0.384 0.127 0.000 0.000 0.004 0.000 0.000

AlaSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.114 -0.177 0.075 0.000 0.000 0.000 0.144 0.092 0.355

psi2 0.000 0.012 0.000 0.011 0.000 0.001 0.002 0.006 0.008

psi3 0.000 -0.101 0.021 -0.132 0.000 0.000 0.002 0.000 0.000

psi4 0.000 0.341 0.520 -0.485 0.000 0.000 0.017 0.000 0.000

psi5 0.001 -0.187 -0.044 0.055 0.000 0.000 0.076 0.001 0.000

psi6 0.032 -0.051 0.020 0.001 0.000 0.040 0.101 0.000 0.000

psi7 0.172 0.865 0.310 0.000 0.000 0.219 0.000 0.000 0.000

psi8 -0.451 6.260 1.052 0.060 0.000 0.000 0.000 0.000 0.002

psi9 -5.454 -1.463 1.823 0.198 0.000 0.000 0.001 0.072 -0.013

AlaSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.017 0.097 0.363 0.000 0.000 0.000 0.112 0.117 0.299

psi2 0.092 0.029 0.000 0.000 0.000 0.000 0.131 0.000 0.012

psi3 0.000 0.020 0.050 0.068 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.113 -0.700 0.140 0.000 0.000 0.000 0.016 0.000

psi5 0.000 -0.083 -0.626 0.058 0.000 0.000 0.072 0.017 0.000

psi6 0.018 -0.012 0.031 0.000 0.000 0.027 0.071 0.000 0.000

psi7 0.151 0.435 0.325 0.000 0.000 0.001 0.012 0.000 0.091

psi8 0.343 8.464 2.344 0.240 0.005 0.000 0.000 0.017 0.237

psi9 -2.984 2.459 0.636 0.167 0.000 0.000 0.110 0.095 0.160

AlaSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.087 0.047 0.005 0.000 0.000 0.000 -1.062 0.000 0.089

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.018 0.000 0.000

psi3 0.000 0.006 0.017 -0.059 0.000 0.000 0.000 0.016 0.000

psi4 0.000 -0.165 0.005 -0.374 0.017 0.000 0.025 0.000 0.000

psi5 0.030 0.127 0.201 0.098 0.000 0.003 0.066 0.033 0.000

psi6 0.004 0.158 -0.022 0.017 0.000 0.068 0.052 0.000 0.000

psi7 0.146 -0.067 0.163 0.000 0.000 0.000 0.000 0.000 0.030

psi8 0.421 2.031 0.864 0.207 0.000 0.000 0.017 0.000 0.030

psi9 -0.473 0.242 0.253 0.340 0.000 0.000 0.017 0.000 0.001

AlaLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.114 -0.340 0.457 0.011 0.000 -0.069 0.174 0.190 0.166

psi2 0.026 -0.053 0.006 -0.015 0.030 -0.198 0.033 0.003 0.005

psi3 0.008 0.173 0.506 0.056 0.000 0.012 0.007 0.056 0.001

psi4 0.020 0.318 0.164 0.281 0.000 0.001 0.074 0.074 0.018

psi5 0.177 0.489 0.484 0.041 0.000 0.004 0.904 0.362 0.002

psi6 -0.129 -0.160 -0.097 0.011 0.000 -0.292 0.277 0.029 0.000

psi7 -0.297 0.256 -0.757 -0.180 0.013 0.262 0.013 0.003 0.001

psi8 -0.510 3.087 2.725 -0.225 0.000 -0.206 0.028 0.084 0.036

psi9 -3.944 0.931 -1.902 0.860 0.000 0.000 0.421 0.194 -0.240

AlaLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.194 0.228 1.538 0.034 0.000 0.037 1.141 0.323 0.400

psi2 0.010 0.040 0.209 0.023 0.002 -0.029 0.432 0.020 0.018

psi3 0.069 0.203 -0.319 -0.485 0.035 0.141 -0.338 0.000 0.031

psi4 0.215 0.157 -1.416 0.134 0.015 0.000 0.286 0.136 -0.066

psi5 0.180 2.111 -0.043 0.206 0.001 0.043 0.964 0.310 0.013

psi6 0.126 0.408 0.180 0.001 0.040 0.941 0.987 0.041 -0.038

psi7 0.412 1.647 2.078 0.148 0.020 -0.017 0.188 0.028 0.038

psi8 0.244 2.629 0.152 -2.955 0.018 0.012 0.223 0.188 0.150

psi9 0.258 4.781 -4.574 -1.972 0.018 0.023 0.476 0.318 -1.605

AlaLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.131 0.229 0.238 -0.003 0.016 0.087 0.316 0.255 0.036

psi2 -0.004 0.103 0.086 0.014 0.004 0.329 0.661 0.039 0.044

psi3 0.286 0.189 -0.329 0.329 -0.187 0.133 0.463 0.044 0.006

psi4 -0.392 -0.389 -5.812 -2.392 0.028 0.048 0.416 0.289 0.031

psi5 0.250 -0.886 1.893 0.380 0.017 0.088 1.644 0.784 0.008

psi6 0.205 -1.170 -0.929 -0.380 0.011 1.313 1.317 0.080 0.049

psi7 -0.124 -0.412 -1.381 0.148 0.145 -0.144 -0.275 -0.173 0.004

psi8 -0.098 2.638 -1.666 -1.088 0.046 0.022 -0.162 0.034 0.029

psi9 -2.063 2.647 0.992 -0.843 0.000 0.000 0.048 0.008 0.056

GlyHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.025 0.004 -0.169 0.000 0.000 0.006 -0.762 -0.068 -0.076

psi2 0.005 0.002 -0.164 0.000 0.000 -0.304 -0.126 0.000 0.000

psi3 0.008 0.033 0.160 -0.484 0.025 0.000 0.000 0.000 0.000

psi4 0.013 0.472 9.112 7.081 0.000 0.000 0.000 -0.011 0.000

psi5 -0.061 0.852 0.937 -0.107 0.000 0.000 -0.269 -0.253 -0.170

psi6 0.009 -0.461 -0.288 0.006 0.000 0.021 -0.676 0.000 0.000

psi7 0.042 0.154 0.091 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.017 0.250 0.840 0.127 0.000 0.000 0.004 -0.347 -0.122

psi9 0.023 -0.068 0.276 -0.076 0.000 0.000 -0.244 -0.198 -0.025

GlyHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.032 -0.008 -0.519 0.000 0.000 -0.096 -1.452 -0.073 0.000

psi2 0.000 -0.253 0.083 0.000 0.000 -0.106 -0.599 0.000 0.000

psi3 0.001 0.050 0.470 1.035 0.004 0.000 -0.044 0.000 0.000

psi4 0.000 1.001 9.836 6.622 0.031 0.000 -0.087 0.000 0.012

psi5 -0.015 1.381 3.195 0.365 0.000 0.001 -1.977 -0.310 0.000

psi6 0.013 0.164 0.281 0.000 0.000 -0.249 -0.724 -0.143 0.000

psi7 0.073 0.297 0.298 0.011 0.000 0.021 -0.124 0.000 0.000

psi8 0.045 0.163 0.580 0.220 0.000 0.000 0.001 -0.161 0.000

psi9 -0.267 0.273 0.178 0.062 0.000 0.000 -3.382 -0.225 -0.263

Glyhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.003 -0.062 0.000 0.000 -0.074 -0.335 -0.167 0.000

psi2 0.000 0.007 0.000 0.000 0.045 -0.898 -0.125 0.000 0.000

psi3 0.017 0.027 1.260 0.478 0.037 -0.038 0.000 0.000 0.004

psi4 0.077 0.742 10.456 8.167 0.066 0.000 0.027 0.000 0.000

psi5 0.031 1.237 1.582 0.113 0.000 0.004 -3.997 -0.290 -0.091

psi6 0.020 0.325 0.077 0.000 0.000 0.278 -1.217 -0.093 0.000

psi7 0.027 0.039 0.037 0.000 0.000 -0.032 0.000 0.000 0.000

psi8 0.004 0.015 0.191 0.050 0.000 0.005 0.000 0.000 0.000

psi9 0.026 0.030 0.214 0.081 0.000 0.000 0.004 0.000 0.000

GlySB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -4.850 -0.817 -0.263 0.000 0.000 0.000 -0.096 -0.614 -3.783

psi2 0.000 -0.190 -0.071 0.014 0.000 0.001 -0.121 -0.056 -0.379

psi3 0.050 -0.125 0.018 0.139 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.208 0.620 0.719 0.000 0.000 -0.171 0.000 0.000

psi5 0.001 0.132 0.231 0.045 0.000 0.000 -1.092 -0.092 0.000

psi6 0.046 0.047 -0.760 0.031 0.000 0.008 -0.030 -0.103 0.000

psi7 0.024 0.846 0.405 0.000 0.000 0.012 0.000 0.000 0.000

psi8 1.550 11.925 5.680 0.379 0.000 0.000 0.000 -0.168 -0.016

psi9 0.643 3.324 1.515 0.088 0.000 0.000 0.000 -0.882 -1.587

GlySM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -2.543 -0.469 0.562 0.000 0.000 0.000 -0.919 -1.933 -8.273

psi2 -0.780 0.024 0.000 0.000 0.000 0.000 -0.700 0.000 -1.228

psi3 0.000 0.017 0.028 0.064 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.357 0.932 0.758 0.000 0.000 0.000 -0.171 0.000

psi5 0.000 0.624 0.516 0.016 0.000 0.000 -1.031 -0.305 0.000

psi6 0.086 -0.034 0.046 0.000 0.000 0.043 -0.722 0.000 0.000

psi7 0.237 0.979 0.872 0.000 0.000 0.000 -0.005 0.000 -0.700

psi8 2.745 11.163 4.086 0.531 0.004 0.000 0.000 -0.559 -0.145

psi9 1.817 6.549 2.513 0.329 0.000 0.000 -0.783 -0.650 -2.185

Glyse

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -1.432 -0.107 0.059 0.000 0.000 0.000 -0.447 0.000 -0.296

psi2 0.000 0.000 0.000 0.000 0.000 0.000 -0.170 0.046 0.000

psi3 0.000 0.004 0.028 -0.046 0.000 0.000 0.000 -0.171 0.000

psi4 0.000 0.222 0.304 0.391 0.013 0.000 -0.440 0.000 0.000

psi5 0.068 0.034 -0.064 0.040 0.000 0.004 -0.939 -0.342 0.000

psi6 0.005 0.060 0.014 0.013 0.000 -0.101 -1.003 0.000 0.000

psi7 0.171 0.271 0.024 0.000 0.000 0.000 0.000 0.000 0.045

psi8 0.777 4.426 2.275 0.404 0.000 0.000 -0.156 0.000 0.045

psi9 -0.116 1.857 1.000 0.414 0.000 0.000 -0.171 0.000 0.001

GlyLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.093 -1.332 -2.357 -0.082 0.000 -0.582 -2.464 -1.170 -0.234

psi2 0.094 -0.185 -0.056 0.001 -0.314 -0.873 -0.685 0.012 -0.121

psi3 0.001 0.084 0.007 -0.175 0.000 0.010 -0.070 -0.384 0.000

psi4 0.013 0.525 1.843 0.889 0.000 0.001 -0.384 -0.240 -0.131

psi5 -0.017 1.433 1.251 0.100 0.000 0.003 -8.201 -3.161 0.001

psi6 0.082 0.833 0.283 0.014 0.000 -0.121 -2.993 0.021 -0.122

psi7 0.305 1.051 1.112 0.029 0.011 0.227 -0.172 0.017 0.000

psi8 0.927 4.955 5.453 1.694 0.000 0.021 -0.176 -1.150 0.011

psi9 0.307 1.334 3.897 0.362 0.000 0.000 -1.576 -1.624 -1.594

Glylm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -2.665 -2.178 -4.348 0.079 0.000 0.320 -6.773 -5.427 -3.774

psi2 0.091 -0.335 -0.640 -0.382 0.001 -0.882 -1.508 0.152 -0.082

psi3 0.226 0.465 0.317 0.429 0.048 0.206 -0.018 0.000 -0.384

psi4 0.098 1.054 3.701 1.889 0.023 -0.017 -0.779 -3.517 -0.057

psi5 0.108 0.492 5.098 0.327 0.000 0.246 -17.712 -8.307 0.015

psi6 0.071 1.746 0.161 0.001 -0.460 1.260 -5.838 -0.443 -0.024

psi7 0.577 1.195 1.493 0.084 0.033 0.272 -0.161 -0.211 0.175

psi8 1.396 5.893 8.366 3.655 0.019 0.010 -0.717 -1.848 -0.513

psi9 2.991 6.294 4.299 2.748 0.003 0.024 -7.230 -4.335 -2.253

GlyLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.180 -1.389 -2.311 0.001 0.023 -0.363 -3.598 -0.748 -1.052

psi2 0.061 -0.395 -0.106 0.017 -0.158 -4.250 -6.312 -0.369 -0.535

psi3 -0.390 0.244 0.051 0.123 0.013 -0.224 -1.215 -0.508 -0.127

psi4 0.043 1.408 5.942 3.306 0.158 -0.799 -9.133 -4.528 0.147

psi5 0.052 0.691 4.722 0.078 0.017 -0.809 -28.190 -9.361 0.075

psi6 -1.234 1.156 -0.526 0.177 0.009 3.142 -10.486 -1.413 -0.413

psi7 0.296 1.463 -0.115 0.142 -0.064 -0.394 0.628 0.014 -0.040

psi8 1.059 3.360 6.141 3.538 -0.086 -0.006 -1.058 -0.023 0.013

psi9 0.756 2.389 4.999 1.957 0.000 0.000 -2.362 -0.067 -0.005

ProHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.008 0.003 0.003 0.000 0.000 0.004 0.039 0.000 0.000

psi2 0.003 0.001 0.014 0.000 0.000 0.008 0.002 0.000 0.000

psi3 0.043 0.026 0.190 0.230 0.009 0.000 0.000 0.000 0.000

psi4 0.010 0.230 14.967 2.325 0.000 0.000 0.000 0.002 0.000

psi5 0.015 0.430 1.660 0.075 0.000 0.000 0.010 0.011 0.000

psi6 0.007 0.097 -0.010 0.004 0.000 0.047 0.021 0.000 0.000

psi7 0.016 0.051 -0.119 0.000 0.000 0.000 0.000 0.000 0.000

psi8 0.009 0.134 -0.080 -0.390 0.000 0.000 0.004 0.007 0.000

psi9 0.018 0.140 0.164 -0.028 0.000 0.000 0.006 0.005 0.000

ProHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.011 0.137 0.037 0.000 0.000 0.004 0.037 0.010 0.000

psi2 0.000 0.344 0.004 0.000 0.000 0.042 0.007 0.000 0.000

psi3 0.001 0.025 0.418 0.921 0.003 0.000 0.001 0.000 0.000

psi4 0.000 0.623 16.509 -2.329 0.041 0.000 0.001 0.000 0.010

psi5 0.003 1.241 3.353 0.055 0.000 0.240 0.077 0.005 0.000

psi6 0.008 0.156 -0.274 0.000 0.000 0.067 0.032 0.000 0.000

psi7 0.110 0.227 0.289 -0.077 0.000 0.017 0.002 0.000 0.000

psi8 0.018 0.190 -1.847 -0.706 0.000 0.000 0.001 0.001 0.000

psi9 0.267 0.191 -2.277 -1.352 0.000 0.000 0.056 0.010 0.001

ProHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.036 0.004 0.000 0.000 0.003 0.004 0.000 0.000

psi2 0.000 0.005 0.000 0.000 0.023 0.012 0.006 0.000 0.000

psi3 0.012 0.017 0.469 -1.630 0.064 0.001 0.000 0.000 0.002

psi4 0.045 0.464 8.206 -9.439 0.069 0.000 0.002 0.000 0.000

psi5 0.024 0.981 1.446 -1.098 0.000 0.003 0.753 0.008 0.003

psi6 0.020 0.166 0.046 0.000 0.000 0.158 0.269 0.002 0.000

psi7 0.012 0.030 0.114 0.000 0.000 0.015 0.000 0.000 0.000

psi8 0.003 0.010 0.122 -0.224 0.000 0.003 0.000 0.000 0.000

psi9 0.189 0.564 -1.376 -1.855 0.000 0.000 0.002 0.000 0.000

ProSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.302 0.189 -0.078 0.000 0.000 0.000 0.011 0.034 0.251

psi2 0.000 0.012 0.000 0.012 0.000 0.001 0.001 0.003 0.005

psi3 0.000 0.015 0.042 0.090 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.074 0.438 0.351 0.000 0.000 0.014 0.000 0.000

psi5 0.000 0.330 0.113 0.023 0.000 0.000 0.023 0.001 0.000

psi6 0.024 0.094 0.014 0.000 0.000 0.004 0.001 0.000 0.000

psi7 0.023 0.350 0.427 0.000 0.000 0.005 0.000 0.000 0.000

psi8 1.084 10.382 2.505 0.038 0.000 0.000 0.000 0.000 0.001

psi9 4.312 5.661 -3.525 -0.431 0.000 0.000 0.000 0.040 0.199

ProSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.423 0.250 -0.324 0.000 0.000 0.000 0.058 0.064 0.312

psi2 0.039 0.028 0.000 0.000 0.000 0.000 0.018 0.000 0.006

psi3 0.000 0.015 0.054 0.098 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.093 0.899 -0.222 0.000 0.000 0.000 0.014 0.000

psi5 0.000 0.338 0.394 -0.169 0.000 0.000 0.058 0.056 0.000

psi6 0.046 0.030 0.021 0.000 0.000 0.015 0.057 0.000 0.000

psi7 0.135 0.461 0.837 0.000 0.000 0.000 0.014 0.000 0.148

psi8 1.996 8.153 -2.181 -1.565 0.004 0.000 0.000 0.014 0.091

psi9 4.061 6.159 -2.605 -0.619 0.000 0.000 0.056 0.262 0.153

ProSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.064 0.324 0.002 0.000 0.000 0.000 0.002 0.000 0.014

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.014 0.000 0.000

psi3 0.000 0.004 0.053 -0.116 0.000 0.000 0.000 0.013 0.000

psi4 0.000 0.049 0.497 -0.214 0.014 0.000 0.020 0.000 0.000

psi5 0.023 0.090 -0.103 -0.328 0.000 0.002 0.063 0.027 0.000

psi6 0.002 0.089 0.014 -0.171 0.000 0.134 0.038 0.000 0.000

psi7 0.127 0.234 -0.327 0.000 0.000 0.000 0.000 0.000 0.023

psi8 0.603 2.315 -1.452 -2.468 0.000 0.000 0.014 0.000 0.023

psi9 0.892 1.197 -2.000 -0.700 0.000 0.000 0.014 0.000 0.000

ProLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.297 0.105 -0.227 0.009 0.000 0.019 0.436 0.070 0.052

psi2 0.013 0.063 0.003 0.001 0.023 0.034 0.027 0.171 0.002

psi3 0.003 0.083 0.156 0.026 0.000 0.014 0.004 0.023 0.000

psi4 0.011 0.374 0.619 -0.881 0.000 0.000 0.036 0.043 0.010

psi5 0.048 1.207 1.869 -0.074 0.000 0.002 0.658 0.146 0.001

psi6 0.256 0.787 -0.938 -0.192 0.000 0.395 0.222 0.003 0.000

psi7 0.107 0.738 -0.091 0.025 0.014 0.207 0.047 0.001 0.000

psi8 0.764 3.288 1.706 -1.911 0.000 0.120 0.021 0.198 0.025

psi9 1.945 2.696 -7.238 -1.972 0.000 0.000 0.078 0.074 0.133

ProLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.578 0.455 -0.748 -0.272 0.000 0.020 0.965 0.228 0.318

psi2 0.014 0.142 -0.707 -0.287 0.033 0.055 0.154 0.011 0.013

psi3 0.076 0.111 0.119 -0.291 0.020 0.019 0.036 0.000 0.109

psi4 0.053 0.682 -0.615 -6.385 -0.190 0.000 0.149 0.083 0.016

psi5 0.099 3.023 -4.633 -1.571 0.000 0.030 2.116 0.395 0.020

psi6 0.110 1.433 -0.881 0.001 0.004 1.743 0.710 0.018 0.004

psi7 0.322 0.174 -0.586 -0.025 0.021 0.403 0.222 0.025 0.031

psi8 1.527 4.547 -2.045 -9.394 -0.279 0.014 0.177 0.030 0.100

psi9 3.542 5.430 -17.112 -8.114 0.013 0.045 0.376 0.116 0.469

ProLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.050 0.233 -0.716 0.001 0.008 0.142 0.404 0.009 0.141

psi2 0.044 0.096 -0.096 0.014 0.004 0.286 0.450 0.010 0.028

psi3 0.096 0.015 -0.200 -0.766 0.014 0.016 0.062 0.126 0.003

psi4 0.094 0.969 -5.452 -14.152 0.017 -0.094 0.556 0.232 0.024

psi5 0.146 2.882 -6.399 -2.025 0.009 0.268 3.211 0.443 0.006

psi6 0.156 0.932 -1.042 -1.635 0.007 1.926 1.982 0.033 0.033

psi7 0.147 0.630 -3.850 -0.378 0.031 0.209 0.196 0.012 0.004

psi8 0.502 3.282 -7.927 -9.148 0.018 0.015 0.054 0.032 0.061

psi9 1.371 1.857 -18.645 -9.118 0.000 0.000 0.030 0.086 0.037

AsnHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.023 0.003 -0.172 0.000 0.000 0.004 0.129 0.000 0.000

psi2 0.019 0.002 0.008 0.000 0.000 0.011 0.002 0.000 0.000

psi3 -0.159 -0.074 0.216 0.247 0.032 0.000 0.000 0.000 0.000

psi4 0.014 0.126 13.045 4.327 0.000 0.000 0.000 0.003 0.000

psi5 0.010 0.807 1.254 0.139 0.000 0.000 0.014 0.028 0.000

psi6 0.004 -0.164 -0.059 0.003 0.000 0.018 0.026 0.000 0.000

psi7 0.034 -0.190 0.043 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.015 0.079 -0.452 -0.170 0.000 0.000 0.002 0.022 0.000

psi9 -0.006 0.148 0.250 0.027 0.000 0.000 0.006 0.005 0.000

AsnHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.279 -0.351 -0.349 0.000 0.000 0.003 0.056 0.007 0.000

psi2 0.000 0.001 0.006 0.000 0.000 0.061 0.037 0.000 0.000

psi3 0.001 -0.014 0.720 0.797 0.003 -0.016 0.001 0.000 0.000

psi4 0.000 -0.362 2.594 4.601 0.046 0.000 0.001 0.000 0.006

psi5 -0.002 -1.525 -0.662 0.393 0.000 0.223 0.037 0.004 0.000

psi6 -0.103 -0.657 -0.449 0.000 0.000 -0.910 0.120 0.000 0.000

psi7 -0.633 -0.854 0.040 0.006 0.000 -0.069 0.002 0.000 0.000

psi8 -1.078 -0.292 -0.008 -0.737 0.000 0.000 0.001 0.001 -0.066

psi9 -0.011 -0.958 -1.362 -0.095 0.000 0.000 0.217 0.008 0.001

Asnhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 -0.261 -0.080 0.000 0.000 0.002 0.035 0.000 0.000

psi2 0.000 0.004 0.000 0.000 0.034 0.154 0.003 0.000 0.000

psi3 0.007 0.023 -0.148 0.201 0.025 0.003 0.000 0.000 0.002

psi4 0.055 0.349 -0.194 0.876 0.048 0.000 0.002 0.000 0.000

psi5 0.024 -1.188 -5.358 -1.009 0.000 0.002 -0.144 0.043 0.002

psi6 0.034 0.098 -0.057 0.000 0.000 -1.237 -1.442 0.002 0.000

psi7 -0.326 0.188 -0.758 0.000 0.000 -0.036 0.000 0.000 0.000

psi8 -0.076 -0.111 -1.265 -0.023 0.000 0.002 0.000 0.000 0.000

psi9 0.005 0.835 -0.486 0.037 0.000 0.000 0.002 0.000 0.000

AsnSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.331 -0.044 0.048 0.000 0.000 0.000 0.018 0.044 0.097

psi2 0.000 0.060 0.000 0.015 0.000 0.001 0.001 0.004 0.004

psi3 0.000 0.017 0.028 0.008 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.246 0.464 0.174 0.000 0.000 0.002 0.000 0.000

psi5 0.000 0.098 0.020 0.023 0.000 0.000 0.023 0.001 0.000

psi6 0.024 0.040 0.034 0.000 0.000 -0.149 0.139 0.000 0.000

psi7 -0.003 0.633 -0.189 0.000 0.000 0.010 0.000 0.000 0.000

psi8 1.128 8.405 3.157 0.086 0.000 0.000 0.000 0.000 0.001

psi9 2.757 5.488 0.889 0.061 0.000 0.000 0.000 0.038 0.062

AsnSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.536 -0.614 0.160 0.000 0.000 0.000 0.107 0.159 0.482

psi2 0.117 0.151 0.000 0.000 0.000 0.000 0.014 0.000 0.009

psi3 0.000 0.029 -0.033 0.010 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.211 -0.253 0.211 0.000 0.000 0.000 0.002 0.000

psi5 0.000 -0.251 -0.358 -0.010 0.000 0.000 0.017 0.017 0.000

psi6 0.002 -0.050 0.024 0.000 0.000 0.032 -0.082 0.000 0.000

psi7 -0.451 1.225 -0.481 0.000 0.000 0.000 0.017 0.000 0.069

psi8 0.974 5.174 0.127 0.292 0.003 0.000 0.000 0.003 0.085

psi9 0.783 3.088 1.051 0.087 0.000 0.000 0.046 0.042 0.266

AsnSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.167 0.044 0.003 0.000 0.000 0.000 0.004 0.000 0.116

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.003 0.000 0.000

psi3 0.000 0.002 0.002 0.115 0.000 0.000 0.000 0.002 0.000

psi4 0.000 0.046 0.329 0.216 0.002 0.000 0.083 0.000 0.000

psi5 0.023 -0.439 -0.162 0.049 0.000 0.002 0.021 0.004 0.000

psi6 -0.007 -0.865 0.095 0.002 0.000 -1.441 -0.237 0.000 0.000

psi7 0.284 -0.058 0.099 0.000 0.000 0.022 0.000 0.000 -0.406

psi8 -1.983 -2.307 0.639 0.103 0.000 0.000 0.003 0.000 0.023

psi9 0.210 0.438 0.137 -0.568 0.000 0.000 0.017 0.000 0.000

AsnLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.654 0.131 0.520 0.007 0.000 0.016 0.098 0.039 0.082

psi2 0.015 0.069 0.003 0.001 0.023 -0.064 0.030 0.001 0.001

psi3 0.005 0.058 0.145 0.027 0.000 0.016 0.003 0.023 0.000

psi4 0.010 0.041 0.269 0.014 0.000 0.000 0.045 0.041 0.007

psi5 -0.146 0.657 -0.609 0.030 0.000 -0.104 0.649 0.136 0.001

psi6 -0.280 -0.476 -0.728 0.010 0.000 -0.694 -0.049 0.003 0.000

psi7 -0.065 0.152 -1.461 0.020 0.017 0.116 0.023 0.002 0.000

psi8 0.064 3.201 0.653 1.912 0.000 0.046 0.185 0.257 0.026

psi9 1.740 1.226 3.830 0.955 0.000 0.000 0.099 0.149 0.098

AsnLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -1.466 -0.507 -0.558 0.310 0.000 0.017 0.433 0.223 0.016

psi2 0.051 0.061 -0.048 0.004 0.001 -0.236 0.216 0.027 0.003

psi3 0.088 -0.126 -0.393 0.189 -0.152 0.012 0.338 0.000 0.023

psi4 0.064 0.755 2.196 1.161 0.011 0.000 -0.151 0.153 0.007

psi5 0.212 -2.398 0.559 0.194 0.000 -0.288 0.290 0.467 0.010

psi6 -1.077 -2.108 -1.337 0.000 0.006 -3.343 -1.461 0.011 0.004

psi7 -0.497 -1.979 -4.336 -0.411 0.018 -0.709 -0.122 0.012 0.025

psi8 -0.471 -0.716 -1.478 0.497 0.012 0.016 0.225 0.029 -0.324

psi9 0.598 -0.766 3.731 1.933 0.003 0.026 0.477 0.215 0.063

AsnLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.020 0.284 0.147 0.001 0.031 0.030 0.293 0.006 0.029

psi2 0.069 0.165 -0.010 -0.002 0.005 -0.329 0.338 0.017 0.030

psi3 0.052 0.022 0.438 -0.056 -0.011 0.013 0.176 0.046 0.021

psi4 -2.677 0.689 0.951 2.434 0.035 0.030 0.447 0.034 -0.076

psi5 -0.562 -6.274 -5.163 0.242 -0.367 -1.147 0.032 0.139 -0.121

psi6 -0.260 -5.692 -0.794 0.144 0.008 -8.131 -2.529 0.017 0.029

psi7 -0.609 -0.391 -1.749 -0.146 0.041 -1.174 -0.827 0.008 0.004

psi8 -0.736 0.269 -3.762 1.022 -0.068 -0.808 0.075 0.002 0.198

psi9 0.127 1.681 0.618 -0.294 0.000 0.000 0.037 0.007 -0.023

ThrHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.015 0.004 0.004 0.000 0.000 0.005 0.033 0.000 0.000

psi2 -0.092 0.002 0.017 0.000 0.060 0.016 0.003 0.000 0.000

psi3 0.032 0.083 0.221 0.214 0.009 0.000 0.000 0.000 0.000

psi4 0.015 -0.202 6.650 2.569 0.000 0.000 0.000 0.003 0.000

psi5 0.019 -0.203 0.095 -0.603 0.000 0.000 0.015 0.011 0.000

psi6 0.008 0.163 0.093 0.006 0.000 0.046 0.028 0.000 0.000

psi7 0.028 0.165 0.118 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.014 -0.063 0.103 0.189 0.000 0.000 0.003 0.156 0.000

psi9 0.027 -0.455 -0.036 0.025 0.000 0.000 0.007 0.007 0.000

ThrHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.018 -0.042 0.161 0.000 0.000 0.022 0.156 0.010 0.000

psi2 0.000 -0.053 0.006 0.000 0.000 0.233 0.021 0.000 0.000

psi3 0.001 -0.112 1.610 1.396 0.004 0.000 0.002 0.000 0.000

psi4 0.000 -0.577 3.362 4.601 0.044 0.000 0.001 0.000 0.010

psi5 0.054 0.021 -0.456 0.891 0.000 -0.313 0.190 0.006 0.000

psi6 0.011 0.091 0.325 0.000 0.000 0.125 0.019 0.000 0.000

psi7 0.071 0.186 0.253 0.009 0.000 0.022 0.002 0.000 0.000

psi8 0.169 0.162 -0.226 0.066 0.000 0.000 0.001 0.001 0.000

psi9 -0.684 -1.825 -2.371 0.156 0.000 0.000 0.097 0.013 0.027

Thrhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 -0.044 0.010 0.000 0.000 0.003 0.004 0.000 0.000

psi2 0.000 0.007 0.000 0.000 0.013 0.340 0.246 0.000 0.000

psi3 0.015 -0.092 0.587 0.902 0.204 0.001 0.001 0.000 0.003

psi4 0.046 -1.761 4.588 -2.136 0.014 0.000 0.003 0.000 0.000

psi5 0.028 -1.137 -2.367 0.433 0.000 0.003 0.396 0.010 0.004

psi6 0.032 -0.244 0.063 0.000 0.000 0.169 0.108 0.003 0.000

psi7 -0.067 0.035 0.017 0.000 0.000 0.017 0.000 0.000 0.000

psi8 0.003 0.014 0.443 0.034 0.000 0.009 0.000 -0.913 0.000

psi9 -0.255 -0.473 -2.876 0.088 0.000 0.000 0.004 0.000 0.000

ThrSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.114 -0.332 0.047 0.000 0.000 0.000 0.011 0.038 0.276

psi2 0.000 0.013 0.000 0.012 0.000 0.001 0.001 0.004 0.006

psi3 0.000 0.014 0.010 0.015 0.000 0.000 0.001 0.000 0.000

psi4 0.000 -0.137 0.561 0.314 0.000 0.000 0.005 0.000 0.000

psi5 0.001 0.075 0.125 0.014 0.000 0.000 0.014 0.001 0.000

psi6 0.014 0.017 0.018 0.001 0.000 0.007 0.001 0.000 0.000

psi7 0.137 0.377 0.516 0.000 0.000 0.009 0.000 0.000 0.000

psi8 1.555 3.603 5.182 0.261 0.000 0.000 0.000 0.000 0.001

psi9 2.397 -1.763 0.427 0.138 0.000 0.000 0.001 0.029 0.061

ThrSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.491 0.131 0.213 0.000 0.000 0.000 0.049 0.161 0.402

psi2 0.128 0.017 0.000 0.000 0.000 0.000 0.024 0.000 0.010

psi3 0.000 0.009 0.103 0.080 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.011 0.459 0.693 0.000 0.000 0.000 0.005 0.000

psi5 0.000 -0.370 -0.179 0.007 0.000 0.000 0.049 0.006 0.000

psi6 0.047 0.024 0.014 0.000 0.000 0.027 0.145 0.000 0.000

psi7 -0.673 0.812 0.069 0.000 0.000 0.000 0.013 0.000 0.065

psi8 0.388 -4.614 1.141 -0.843 0.004 0.000 0.000 0.005 -0.012

psi9 2.574 -4.444 0.930 -0.770 0.000 0.000 0.029 0.052 0.514

ThrSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.794 0.052 0.004 0.000 0.000 0.000 0.002 0.000 0.006

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.006 0.000 0.000

psi3 0.000 0.003 0.005 0.153 0.000 0.000 0.000 0.004 0.000

psi4 0.000 -0.578 0.330 0.111 0.005 0.000 0.022 0.000 0.000

psi5 0.013 -0.430 0.206 0.015 0.000 0.003 0.031 0.010 0.000

psi6 0.003 0.010 0.005 0.005 0.000 0.118 0.040 0.000 0.000

psi7 0.267 0.241 0.201 0.000 0.000 0.000 0.000 0.000 0.013

psi8 0.731 -5.182 -1.679 0.135 0.000 0.000 0.005 0.000 0.013

psi9 -0.412 -4.301 -1.284 0.202 0.000 0.000 0.005 0.000 0.001

ThrLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.368 0.319 -0.374 0.011 0.000 0.214 0.550 0.067 0.032

psi2 0.017 0.219 0.004 0.001 0.013 0.045 0.037 0.002 0.003

psi3 0.005 0.134 0.111 -0.160 0.000 0.012 0.004 0.014 0.000

psi4 -0.034 -0.197 1.095 0.874 0.000 -0.136 0.059 0.081 0.010

psi5 0.069 0.057 0.237 0.042 0.000 0.003 1.013 0.247 0.001

psi6 0.165 0.239 -0.009 0.013 0.000 0.296 0.260 0.004 0.000

psi7 0.190 0.264 1.058 0.026 0.013 0.021 0.009 0.002 0.000

psi8 0.231 0.873 2.516 0.336 0.000 -0.057 0.138 0.031 0.017

psi9 -0.347 -1.656 1.856 0.331 0.000 0.000 -0.028 0.073 0.365

ThrLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.097 -1.490 0.469 0.025 0.000 0.085 0.230 0.214 0.441

psi2 0.008 -0.118 -0.117 0.012 0.001 0.187 0.152 0.019 0.009

psi3 -0.093 -1.100 -0.067 -0.444 -0.080 0.020 0.069 0.000 0.014

psi4 -0.243 -1.055 -1.592 0.656 0.015 0.000 0.236 0.079 0.019

psi5 0.257 -3.598 -1.510 0.108 0.000 0.106 1.848 0.346 0.014

psi6 0.321 -0.533 0.449 0.001 0.002 1.240 1.099 0.115 0.005

psi7 0.162 0.019 1.068 0.200 0.032 0.353 0.114 0.022 -0.249

psi8 0.165 -1.201 2.200 2.182 -0.080 0.013 -0.101 0.041 0.079

psi9 -0.286 -8.332 -0.773 2.556 0.010 0.025 0.243 0.406 0.143

ThrLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.077 -0.682 0.219 0.001 0.008 0.057 0.365 0.011 0.038

psi2 0.045 0.095 0.070 0.015 0.006 0.508 0.524 0.037 0.017

psi3 0.002 -0.035 -1.102 0.279 0.010 0.078 0.131 0.076 0.003

psi4 -0.168 -2.190 -2.074 0.670 0.024 0.024 0.493 0.243 -0.111

psi5 -0.757 -5.884 -3.291 0.567 0.017 0.217 3.306 0.367 0.010

psi6 0.184 -0.463 0.430 0.050 0.016 2.743 1.055 0.027 0.033

psi7 -0.153 -0.559 0.736 0.083 -0.225 0.423 0.161 0.144 0.005

psi8 0.306 -4.160 -2.697 1.215 0.031 0.023 0.114 0.003 0.018

psi9 -2.053 -5.463 -2.003 1.289 0.000 0.000 0.051 0.009 0.076

SerHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.006 0.004 0.005 0.000 0.000 0.007 0.026 0.001 0.000

psi2 0.004 0.002 0.016 0.000 0.000 0.017 -0.051 0.000 0.000

psi3 0.010 0.025 0.735 0.489 0.102 0.000 0.000 0.000 0.000

psi4 0.016 0.163 9.489 3.246 0.000 0.000 0.000 0.003 0.000

psi5 0.022 -0.888 -0.760 0.480 0.000 0.000 0.092 0.012 0.000

psi6 -0.113 0.348 0.193 0.006 0.000 -0.039 0.029 0.000 0.000

psi7 0.029 0.102 0.000 0.000 0.000 0.001 0.000 0.000 0.000

psi8 -0.068 -0.025 -0.567 0.070 0.000 0.000 -0.093 0.012 0.000

psi9 -0.284 0.030 -1.503 0.066 0.000 0.000 0.008 0.006 0.000

SerHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.018 -0.275 -0.353 0.000 0.000 0.006 0.047 0.008 0.000

psi2 0.000 0.002 0.005 0.000 0.000 0.027 0.017 0.000 0.000

psi3 0.032 0.142 0.851 -0.632 -0.098 0.000 0.002 0.000 0.000

psi4 0.000 0.265 5.182 4.586 0.058 0.000 0.089 0.001 0.011

psi5 0.004 0.453 0.387 1.168 0.000 0.014 0.054 0.531 0.000

psi6 -0.161 0.096 -0.514 0.000 0.000 0.518 -0.111 0.000 0.000

psi7 0.161 0.521 0.038 0.010 0.000 0.019 0.002 0.000 0.000

psi8 -0.095 -1.518 -1.851 -0.427 0.000 0.000 0.001 0.001 0.000

psi9 -3.026 -0.883 -4.203 -0.188 0.000 0.000 0.077 0.012 0.001

Serhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.004 -0.009 0.000 0.000 0.004 0.005 0.000 0.000

psi2 0.000 0.008 0.000 0.000 0.041 -0.234 0.013 0.000 0.000

psi3 0.017 0.018 -0.084 1.648 0.057 0.020 0.001 0.000 0.050

psi4 0.149 0.020 0.021 2.830 -0.139 0.000 0.003 0.000 0.000

psi5 -0.384 0.663 -4.757 0.032 0.000 0.003 0.665 0.010 0.004

psi6 0.028 -0.054 -0.106 0.000 0.000 0.401 0.244 0.002 0.000

psi7 0.042 0.021 0.019 0.000 0.000 -0.494 0.000 0.000 0.000

psi8 0.003 0.017 0.361 0.110 0.000 0.004 0.000 0.000 0.000

psi9 0.083 0.004 -0.526 -0.210 0.000 0.000 -0.094 0.000 0.000

SerSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.944 0.193 0.146 0.000 0.000 0.000 0.013 0.055 0.328

psi2 0.000 0.014 0.000 0.013 0.000 0.001 0.004 0.004 0.006

psi3 0.000 0.030 0.011 0.098 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.075 0.346 -0.099 0.000 0.000 0.005 0.000 0.000

psi5 0.001 0.116 -0.233 0.034 0.000 0.000 0.035 0.002 0.000

psi6 -0.335 0.037 0.034 0.001 0.000 0.008 0.001 0.000 0.000

psi7 0.135 0.142 0.655 0.000 0.000 0.012 0.000 0.000 0.000

psi8 0.186 10.853 3.934 0.179 0.000 0.000 0.000 0.000 0.115

psi9 -0.998 1.176 -2.266 -0.513 0.000 0.000 0.001 0.063 0.239

SerSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.985 0.342 -1.316 0.000 0.000 0.000 0.310 0.208 0.394

psi2 -0.349 0.020 0.000 0.000 0.000 0.000 0.024 0.000 0.012

psi3 0.000 -0.159 0.024 0.136 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.620 0.528 0.401 0.000 0.000 0.000 0.005 0.000

psi5 0.000 -0.637 0.252 0.008 0.000 0.000 0.029 0.006 0.000

psi6 0.006 0.047 0.162 0.000 0.000 0.029 0.039 0.000 0.000

psi7 -0.156 0.275 0.477 0.000 0.000 0.000 -0.224 0.000 0.148

psi8 0.676 6.089 2.781 0.358 0.004 0.000 0.000 0.006 -0.064

psi9 -5.271 1.228 -2.095 -0.075 0.000 0.000 0.049 0.308 0.191

SerSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.511 0.105 0.004 0.000 0.000 0.000 0.003 0.000 0.043

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.006 0.000 0.000

psi3 0.000 0.004 0.006 0.201 0.000 0.000 0.000 0.005 0.000

psi4 0.000 0.052 0.057 0.098 0.048 0.000 0.027 0.000 0.000

psi5 0.034 0.051 0.103 0.016 0.000 0.004 0.027 0.010 0.000

psi6 0.004 0.027 0.026 0.005 0.000 0.528 0.030 0.000 0.000

psi7 -0.079 0.792 0.219 0.000 0.000 0.000 0.000 0.000 0.034

psi8 0.480 0.688 0.498 0.473 0.000 0.000 0.006 0.000 0.034

psi9 -2.960 -1.264 0.872 0.168 0.000 0.000 0.005 0.000 0.001

SerLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.240 -0.143 0.061 -0.001 0.000 0.056 -0.229 0.138 0.036

psi2 -0.098 -0.056 0.005 0.002 0.034 -0.245 0.056 0.002 0.004

psi3 -0.556 0.086 0.243 -0.023 0.000 0.015 0.045 0.035 0.000

psi4 0.013 0.326 -0.292 0.193 0.000 0.032 -0.037 0.058 0.015

psi5 -0.027 0.432 0.225 -0.086 0.000 0.003 1.291 0.238 0.001

psi6 0.487 0.643 0.513 0.014 0.000 1.028 0.322 0.004 0.000

psi7 -0.091 1.132 1.156 -0.183 -0.121 -0.053 -0.084 0.002 0.000

psi8 0.040 1.554 2.096 1.264 0.000 0.033 0.052 0.027 0.038

psi9 1.227 1.301 -0.196 0.577 0.000 0.000 0.116 0.096 -0.296

SerLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -1.247 -0.163 -0.887 -0.207 0.000 0.167 0.709 0.498 -0.025

psi2 -0.037 0.067 0.133 0.016 -0.135 0.302 0.122 0.028 0.014

psi3 -0.095 -0.484 -0.006 0.104 -0.031 0.021 0.054 0.000 0.034

psi4 -0.140 0.085 0.798 0.809 -0.400 0.000 0.226 0.213 0.020

psi5 -0.019 -0.879 -1.817 0.102 0.001 0.032 1.989 0.459 -0.099

psi6 0.176 0.449 0.164 0.001 0.004 0.696 0.672 0.020 0.119

psi7 -0.428 1.385 -1.292 -0.309 0.031 0.401 -0.106 -0.177 -0.155

psi8 0.164 2.756 2.590 0.695 0.017 0.015 0.177 0.084 0.112

psi9 -3.774 -3.491 -3.858 -0.192 0.015 -0.209 0.450 0.449 0.008

SerLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.036 0.052 -0.508 0.001 0.070 -0.001 0.198 0.127 0.040

psi2 -2.441 -0.090 0.098 0.015 0.005 0.350 0.430 0.022 0.040

psi3 0.012 1.125 0.286 -2.422 0.016 -0.016 -1.221 0.099 0.004

psi4 -0.283 -1.659 -3.759 -0.182 -0.182 0.049 -0.048 0.151 0.064

psi5 -0.695 -3.665 -10.166 -4.031 0.026 0.227 3.128 0.543 0.008

psi6 0.227 -0.241 -1.425 0.249 0.000 0.477 0.652 0.022 0.042

psi7 -0.197 0.433 -0.349 -1.694 0.096 -0.021 -0.168 0.013 0.044

psi8 -0.482 0.122 -1.416 -2.274 0.041 -0.772 0.290 -0.085 -0.727

psi9 -2.606 -0.722 -3.807 -0.244 0.000 0.000 0.048 0.023 0.058

ArgHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.015 0.003 0.003 0.000 0.000 0.003 0.022 0.000 0.000

psi2 0.004 0.001 0.016 0.000 0.000 0.027 0.004 0.000 0.000

psi3 0.003 -0.127 0.266 0.340 0.063 0.000 0.000 0.000 0.000

psi4 0.013 0.269 10.954 6.850 0.000 0.000 0.000 0.002 0.000

psi5 0.016 0.820 2.181 0.239 0.000 0.000 0.010 0.011 0.000

psi6 0.010 -0.054 -0.009 0.004 0.000 0.015 0.019 0.000 0.000

psi7 0.247 0.181 0.120 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.397 0.061 0.143 0.059 0.000 0.000 0.003 0.014 0.000

psi9 0.077 0.074 0.535 0.013 0.000 0.000 0.006 0.006 0.000

ArgHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.356 0.233 0.036 0.000 0.000 0.004 0.045 0.025 0.000

psi2 0.000 0.002 0.005 0.000 0.000 0.074 0.022 0.000 0.000

psi3 0.001 0.018 -0.255 0.192 0.016 0.000 0.000 0.000 0.000

psi4 0.000 1.814 0.589 -3.976 0.052 0.000 0.001 0.000 0.013

psi5 0.003 -0.379 0.889 0.318 0.000 0.001 0.054 0.032 0.000

psi6 0.007 -0.026 -0.116 0.000 0.000 -0.545 0.242 0.000 0.000

psi7 0.080 0.154 0.174 0.008 0.000 0.022 0.002 0.000 0.000

psi8 0.083 0.237 -0.081 -0.016 0.000 0.000 0.001 0.045 0.000

psi9 0.150 0.831 0.047 0.049 0.000 0.000 0.094 0.011 0.001

ArgHE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.002 0.006 0.000 0.000 0.003 0.004 0.000 0.000

psi2 0.000 0.007 0.000 0.000 0.027 0.014 0.009 0.000 0.000

psi3 0.011 0.024 -4.398 -3.058 -0.298 0.002 0.000 0.000 0.002

psi4 0.162 -0.970 -7.408 -3.471 0.027 0.000 0.002 0.000 0.000

psi5 0.023 0.567 0.494 -1.394 0.000 0.003 0.108 0.007 0.004

psi6 -0.364 -0.067 -0.138 0.000 0.000 -0.500 -1.524 0.002 0.000

psi7 0.020 -0.065 0.028 0.000 0.000 0.151 0.000 0.000 0.000

psi8 0.003 0.047 -0.050 -0.444 0.000 0.004 0.000 0.000 0.000

psi9 0.008 0.006 0.235 0.038 0.000 0.000 0.002 0.002 0.000

ArgSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.401 0.422 0.123 0.000 0.000 0.000 0.009 0.092 0.210

psi2 0.000 0.012 0.000 0.011 0.000 0.001 0.001 0.003 0.004

psi3 0.000 0.043 -0.166 0.044 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.087 0.790 0.439 0.000 0.000 0.015 0.000 0.000

psi5 0.000 0.143 0.119 0.088 0.000 0.000 0.027 0.000 0.000

psi6 0.027 0.013 0.023 0.001 0.000 0.007 0.001 0.000 0.000

psi7 -0.221 0.495 0.269 0.000 0.000 0.004 0.000 0.000 0.000

psi8 0.884 6.216 3.758 -0.057 0.000 0.000 0.000 0.000 -0.136

psi9 1.869 4.745 1.256 0.047 0.000 0.000 0.000 0.090 0.064

ArgSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.279 0.885 0.158 0.000 0.000 0.000 0.038 0.141 0.345

psi2 0.050 -0.160 0.000 0.000 0.000 0.000 0.022 0.000 0.008

psi3 0.000 0.017 0.137 0.130 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.182 -0.121 -0.321 0.000 0.000 0.000 0.014 0.000

psi5 0.000 0.191 0.443 0.016 0.000 0.000 0.059 0.015 0.000

psi6 0.054 -0.011 0.027 0.000 0.000 0.022 0.114 0.000 0.000

psi7 0.121 0.784 -0.005 0.000 0.000 0.100 0.010 0.000 0.091

psi8 -0.222 0.860 0.019 0.267 0.004 0.000 0.000 0.015 0.104

psi9 -2.267 -3.820 -0.637 0.297 0.000 0.000 0.067 0.085 0.324

ArgSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.136 -1.055 0.005 0.000 0.000 0.000 0.003 0.000 0.015

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.015 0.000 0.000

psi3 0.000 0.003 -0.170 -0.080 0.000 0.000 0.000 0.014 0.000

psi4 0.000 -0.122 -0.218 -0.575 0.015 0.000 0.014 0.000 0.000

psi5 -0.402 0.082 -0.424 0.043 0.000 -0.043 0.053 0.029 0.000

psi6 0.002 -0.279 -0.141 0.014 0.000 0.079 0.054 0.000 0.000

psi7 0.067 -0.541 0.160 0.000 0.000 0.000 0.000 0.000 0.051

psi8 -1.587 -5.486 -3.145 -1.076 0.000 0.000 0.053 0.000 0.042

psi9 -2.045 -2.227 -1.229 0.413 0.000 0.000 0.015 0.000 0.000

ArgLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.626 0.016 0.286 0.007 0.000 0.021 0.169 0.032 0.045

psi2 0.094 0.051 0.003 0.015 0.073 0.027 0.025 0.002 0.003

psi3 0.004 -0.079 0.161 0.031 0.000 0.009 0.004 0.027 0.000

psi4 0.009 0.407 0.933 0.582 0.000 0.001 0.046 0.089 0.011

psi5 0.047 0.744 1.925 0.042 0.000 0.002 0.825 0.498 0.001

psi6 0.052 0.623 0.309 0.012 0.000 0.023 0.255 0.003 0.000

psi7 0.150 0.405 1.207 0.061 0.010 0.031 0.006 0.002 0.000

psi8 0.560 3.113 3.361 0.816 0.000 0.020 0.021 0.015 -0.048

psi9 0.688 1.264 4.018 0.543 0.000 0.000 0.081 0.049 0.163

ArgLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.232 -0.283 0.680 0.026 0.000 0.020 0.459 0.273 0.164

psi2 0.005 -0.445 0.021 0.017 0.001 0.065 0.060 0.009 0.014

psi3 -0.028 0.188 -0.609 -0.017 0.029 0.026 0.001 0.000 0.027

psi4 0.172 0.696 -2.946 0.077 0.013 0.000 0.647 0.173 0.021

psi5 0.105 0.284 -0.590 0.056 0.000 0.026 2.079 0.466 0.013

psi6 -0.228 -1.815 0.165 0.000 0.011 0.236 0.069 0.019 0.003

psi7 0.412 -0.828 0.235 0.066 0.022 0.056 0.074 0.025 0.035

psi8 -0.960 0.038 1.540 -0.289 0.047 -0.230 0.055 0.034 0.225

psi9 -2.069 -0.005 -0.685 0.933 0.014 0.021 -0.003 0.107 0.125

ArgLE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.130 0.483 -0.645 0.001 0.062 0.043 0.057 0.232 0.035

psi2 0.106 -0.234 -0.165 0.013 0.001 0.008 -0.918 0.014 0.040

psi3 0.159 -0.140 0.036 0.533 0.015 0.016 0.585 0.032 0.287

psi4 0.133 -2.370 -2.121 -0.235 0.019 0.047 0.597 0.163 -0.036

psi5 0.120 -0.213 -3.549 -0.998 0.007 -1.400 1.900 0.478 0.116

psi6 -0.057 -1.237 -2.190 0.146 0.006 -2.797 0.348 0.029 0.033

psi7 -0.060 -1.157 0.327 -2.051 0.089 0.163 0.211 0.014 0.005

psi8 -0.779 -0.699 -1.647 0.211 0.146 0.018 0.072 0.001 0.014

psi9 -2.933 -1.191 -3.600 1.104 0.000 0.000 0.144 0.116 0.061

GlnHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.007 0.003 0.003 0.000 0.000 0.004 0.015 0.000 0.000

psi2 0.003 0.001 0.011 0.000 0.000 0.007 0.004 0.000 0.000

psi3 0.006 0.021 0.350 0.222 0.040 0.000 0.000 0.000 0.000

psi4 0.008 0.124 7.518 5.373 0.000 0.000 0.000 0.002 0.000

psi5 0.011 0.227 -0.131 0.117 0.000 0.000 0.010 0.009 0.000

psi6 0.005 0.107 0.042 0.004 0.000 -0.225 0.025 0.000 0.000

psi7 0.016 0.045 0.031 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.015 0.072 -0.454 0.065 0.000 0.000 0.002 0.006 0.000

psi9 0.098 -0.102 -0.108 0.014 0.000 0.000 0.005 0.004 0.000

GlnHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.009 0.016 -0.066 0.000 0.000 0.004 0.039 0.007 0.000

psi2 0.000 0.001 0.120 0.000 0.000 0.023 0.010 0.000 0.000

psi3 0.060 0.069 0.639 -0.207 0.003 0.000 0.001 0.000 0.000

psi4 0.000 0.533 -6.203 1.295 0.054 0.000 0.001 0.000 0.007

psi5 0.002 -0.561 1.444 0.827 0.000 0.001 0.039 0.004 0.000

psi6 0.008 0.179 0.396 0.000 0.000 0.504 0.012 0.000 0.000

psi7 0.405 -0.307 0.283 0.009 0.000 0.010 0.001 0.000 0.000

psi8 0.059 -0.457 -0.807 0.217 0.000 0.000 0.001 0.001 0.000

psi9 0.415 0.193 1.013 0.087 0.000 0.000 0.068 0.009 0.113

Glnhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.027 0.039 0.000 0.000 0.002 0.003 0.000 0.000

psi2 0.000 0.005 0.000 0.000 0.012 0.013 0.005 0.000 0.000

psi3 0.006 0.008 -1.807 -1.422 0.176 0.003 0.028 0.000 0.002

psi4 0.066 -0.063 -6.735 -8.168 0.012 0.000 -0.262 0.000 0.000

psi5 0.030 -0.817 -3.077 0.426 0.000 0.002 0.095 0.007 0.003

psi6 0.024 0.319 -0.365 0.000 0.000 -0.047 0.054 0.001 0.000

psi7 -0.567 -0.191 0.043 0.000 0.000 -0.003 0.000 0.000 0.000

psi8 0.002 -0.421 -0.013 0.040 0.000 0.003 0.047 0.000 0.000

psi9 0.051 0.161 0.571 0.043 0.000 0.000 0.002 0.000 0.000

GlnSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.235 0.370 0.034 0.000 0.000 0.000 0.012 0.022 0.110

psi2 0.000 0.011 0.000 0.010 0.000 0.001 0.001 0.002 0.004

psi3 0.000 0.009 0.006 -0.174 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.119 0.266 -0.347 0.000 0.000 0.004 0.000 0.000

psi5 0.000 0.074 0.058 0.037 0.000 0.000 0.074 0.002 0.000

psi6 0.013 0.030 0.026 -0.137 0.000 0.005 0.001 0.000 0.000

psi7 0.041 0.010 0.000 0.000 0.000 -0.114 0.000 0.000 0.000

psi8 0.970 3.764 1.902 0.072 0.000 0.000 0.000 0.000 0.001

psi9 2.000 3.682 1.399 0.038 0.000 0.000 0.033 0.020 0.059

GlnSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.486 -0.070 -0.041 0.000 0.000 0.000 0.112 0.032 0.158

psi2 0.037 0.050 0.000 0.000 0.000 0.000 0.015 0.000 0.008

psi3 0.000 0.030 -0.048 0.013 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.157 0.008 0.322 0.000 0.000 0.000 0.003 0.000

psi5 0.000 0.308 0.189 0.004 0.000 0.000 0.019 0.004 0.000

psi6 0.004 0.020 0.037 0.000 0.000 0.030 0.017 0.000 0.000

psi7 0.090 0.012 -0.060 0.000 0.000 0.000 0.008 0.000 0.036

psi8 -0.854 -1.162 1.062 0.193 0.002 0.000 0.000 0.004 0.054

psi9 -1.473 -1.207 0.670 -0.085 0.000 0.000 0.041 0.042 0.059

GlnSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.038 0.035 0.003 0.000 0.000 0.000 0.002 0.000 0.046

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.004 0.000 0.000

psi3 0.000 0.000 0.003 0.031 0.000 0.000 0.000 0.003 0.000

psi4 0.000 0.033 0.109 0.183 0.003 0.000 0.023 0.000 0.000

psi5 0.012 -0.062 0.136 0.107 0.000 0.003 0.020 0.007 0.000

psi6 0.003 0.177 0.025 0.003 0.000 -0.421 0.024 0.000 0.000

psi7 -0.382 0.035 0.054 0.000 0.000 0.000 0.000 0.000 0.012

psi8 -0.351 -2.361 -0.622 0.369 0.000 0.000 0.003 0.000 0.073

psi9 -0.784 -0.917 -0.048 -0.379 0.000 0.000 0.004 0.000 0.000

GlnLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.207 0.267 0.395 0.004 0.000 0.035 0.093 0.032 0.155

psi2 0.017 0.050 0.039 -0.009 0.012 0.029 0.019 0.001 0.002

psi3 0.004 0.286 0.289 0.025 0.000 0.008 -0.093 0.013 0.000

psi4 0.010 0.360 0.774 0.170 0.000 0.000 0.055 0.037 0.012

psi5 0.039 0.188 1.212 0.091 0.000 0.002 0.784 0.181 0.001

psi6 0.193 0.057 0.185 0.011 0.000 -0.345 0.028 0.003 0.000

psi7 0.254 0.709 0.200 0.022 0.008 -0.059 0.121 0.001 0.000

psi8 0.175 1.114 1.042 0.910 0.000 0.016 0.055 0.014 0.015

psi9 0.951 1.198 3.390 0.390 0.000 0.000 0.097 0.423 0.210

Glnlm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.133 0.506 -0.209 0.014 0.000 0.017 0.254 0.159 0.123

psi2 0.004 0.092 0.182 0.012 0.001 0.095 -0.169 0.013 0.005

psi3 0.026 0.155 0.302 -0.046 0.020 0.026 0.065 0.000 0.012

psi4 0.040 0.056 -1.376 0.617 0.013 0.000 0.244 0.058 -0.271

psi5 -0.419 -0.332 1.157 0.229 0.000 -0.013 1.439 0.179 0.011

psi6 0.093 0.645 0.046 0.001 0.004 -0.626 0.525 0.013 0.004

psi7 0.566 0.452 0.694 0.057 0.013 0.142 0.209 0.015 0.021

psi8 -0.535 2.577 0.330 1.929 0.014 0.008 0.066 0.042 0.044

psi9 -1.901 -2.509 2.920 0.166 0.005 0.019 0.356 0.289 0.292

Glnle

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.069 0.219 0.132 0.001 0.039 0.041 0.057 0.003 0.028

psi2 0.213 0.042 0.041 0.012 0.002 -0.350 -0.016 0.010 -0.454

psi3 -0.519 0.139 -0.123 -1.865 0.005 -0.372 0.119 0.033 0.002

psi4 0.067 -0.365 -2.270 -0.387 0.011 0.134 0.591 0.194 -0.152

psi5 0.038 -1.522 -1.567 0.287 0.012 0.048 1.214 0.434 0.004

psi6 0.029 -3.760 0.281 0.066 0.007 -1.388 0.209 0.020 0.019

psi7 -0.437 -0.106 -3.317 -0.064 0.052 0.200 0.346 0.008 0.003

psi8 -1.009 -2.895 -3.050 1.192 0.018 0.012 0.054 -0.152 -1.589

psi9 0.476 -2.705 -3.067 0.903 0.000 0.000 0.032 0.186 0.026

AspHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.526 -0.020 0.089 0.000 0.000 0.005 0.036 0.000 0.000

psi2 0.003 0.002 0.019 0.000 0.000 0.010 0.006 0.000 0.000

psi3 0.005 0.034 0.169 0.697 0.032 0.000 0.000 0.000 0.000

psi4 0.017 0.250 11.567 7.687 0.000 0.000 0.000 0.003 0.000

psi5 0.020 -0.552 -0.128 0.117 0.000 0.000 0.016 0.011 0.000

psi6 0.005 0.048 0.072 0.004 0.000 0.416 0.029 0.000 0.000

psi7 0.035 0.188 -0.157 0.000 0.000 0.001 0.000 0.000 0.000

psi8 -0.038 0.189 -0.102 0.084 0.000 0.000 0.003 0.022 0.000

psi9 -0.105 0.104 0.169 0.052 0.000 0.000 0.012 0.008 0.000

AspHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.314 -0.067 -0.293 0.000 0.000 0.113 0.069 0.074 0.000

psi2 0.000 0.002 -0.091 0.000 0.000 -0.361 0.026 0.000 0.000

psi3 0.001 0.034 0.174 -0.342 0.004 0.000 0.001 0.000 0.000

psi4 0.000 0.257 4.203 2.683 0.023 0.000 0.001 0.000 0.013

psi5 0.019 -0.310 -1.764 0.856 0.000 0.001 0.341 0.256 0.000

psi6 -0.080 -0.131 0.233 0.000 0.000 -0.062 0.019 0.000 0.000

psi7 -0.560 -0.438 -1.200 0.014 0.000 0.021 0.002 0.000 0.000

psi8 -0.034 -2.039 -3.163 -0.799 0.000 0.000 0.001 0.001 0.000

psi9 -0.572 -0.124 -0.103 0.197 0.000 0.000 0.118 0.015 0.001

Asphe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.148 -0.011 0.010 0.000 0.000 0.004 0.036 0.000 0.000

psi2 0.000 0.007 0.000 0.000 0.024 0.015 -0.001 0.000 0.000

psi3 0.015 0.019 -1.500 0.431 -0.025 0.002 0.000 0.000 0.002

psi4 0.025 -0.230 -0.289 -0.655 0.052 0.000 0.003 0.000 0.000

psi5 0.034 0.603 -4.345 -0.375 0.000 0.002 0.052 0.012 0.003

psi6 0.028 -0.485 0.426 0.000 0.000 -2.671 -0.002 0.002 0.000

psi7 0.019 -0.284 -0.785 0.000 0.000 0.015 0.000 0.000 0.000

psi8 0.004 -0.172 0.143 0.029 0.000 0.003 0.000 0.000 0.000

psi9 0.056 -0.390 0.426 -0.109 0.000 0.000 0.003 0.000 0.000

AspSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.532 0.280 -0.519 0.000 0.000 0.000 0.010 0.142 0.188

psi2 0.000 0.011 0.000 0.010 0.000 0.001 0.001 0.004 0.007

psi3 0.000 0.013 -0.036 0.034 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.131 0.253 0.183 0.000 0.000 0.006 0.000 0.000

psi5 0.001 0.128 -0.315 0.024 0.000 0.000 0.070 0.002 0.000

psi6 -0.021 0.014 0.032 0.001 0.000 0.010 0.013 0.000 0.000

psi7 0.022 0.516 0.013 0.000 0.000 0.007 0.000 0.000 0.000

psi8 0.306 6.579 2.778 0.132 0.000 0.000 0.000 0.000 0.001

psi9 3.183 5.845 1.548 0.052 0.000 0.000 0.001 0.016 0.065

AspSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.568 0.258 -0.077 0.000 0.000 0.000 0.250 0.240 0.468

psi2 0.054 0.018 0.000 0.000 0.000 0.000 0.028 0.000 0.006

psi3 0.000 0.011 0.096 0.024 0.000 0.000 0.000 0.000 0.000

psi4 0.000 0.217 0.524 0.610 0.000 0.000 0.000 0.006 0.000

psi5 0.000 -0.437 -0.292 0.008 0.000 0.000 0.028 0.006 0.000

psi6 0.006 -0.004 -0.431 0.000 0.000 -0.493 0.026 0.000 0.000

psi7 0.070 -0.521 -0.842 0.000 0.000 0.000 0.012 0.000 0.167

psi8 0.405 3.908 1.976 0.613 0.004 0.000 0.000 0.021 -0.333

psi9 1.055 4.541 0.885 0.120 0.000 0.000 0.178 0.161 0.165

AspSE

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.273 0.418 -0.144 0.000 0.000 0.000 0.002 0.000 0.045

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.006 0.000 0.000

psi3 0.000 0.003 -0.138 0.062 0.000 0.000 0.000 0.005 0.000

psi4 0.000 0.064 -0.248 0.150 0.006 0.000 0.018 0.000 0.000

psi5 0.024 -0.156 -0.126 0.056 0.000 0.002 0.030 0.011 0.000

psi6 0.003 -0.078 0.006 0.006 0.000 0.041 -0.347 0.000 0.000

psi7 0.036 0.231 0.075 0.000 -0.018 0.000 0.000 0.000 0.045

psi8 0.645 0.627 -0.140 0.208 0.000 0.000 0.006 0.000 0.024

psi9 0.228 0.289 0.776 -0.317 0.000 0.000 0.045 0.000 0.001

AspLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.373 0.474 -0.307 0.009 0.000 0.022 0.146 0.035 0.028

psi2 0.015 -0.002 0.004 0.001 0.024 0.167 0.033 0.002 0.004

psi3 0.008 -0.210 0.143 0.037 0.000 0.012 0.004 0.025 0.000

psi4 0.014 0.355 1.026 0.268 0.000 0.001 0.069 0.051 0.015

psi5 0.056 0.734 1.075 0.050 0.000 0.002 0.834 0.150 0.001

psi6 0.069 0.044 0.110 0.011 0.000 0.306 0.552 0.004 0.009

psi7 -0.215 0.508 -2.282 0.022 0.012 0.020 0.067 0.002 0.000

psi8 0.733 2.757 2.256 0.455 0.000 0.028 0.021 0.034 0.028

psi9 1.293 2.848 3.446 0.654 0.000 0.000 0.441 0.056 0.279

AspLM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.997 0.003 -2.002 -0.013 0.000 0.165 0.598 0.319 0.462

psi2 0.012 0.100 -0.013 0.002 0.001 -0.005 0.175 -0.377 0.007

psi3 -0.008 0.094 0.059 0.059 0.052 -0.164 0.031 0.000 0.024

psi4 0.055 0.947 -0.532 1.289 0.013 0.050 0.435 0.195 0.027

psi5 -0.430 -2.970 -2.127 0.228 0.000 0.023 0.752 0.246 0.011

psi6 0.013 -0.891 0.787 0.001 0.004 -0.788 -1.003 0.060 0.005

psi7 -1.730 -2.223 -1.309 -0.138 -0.175 -0.131 -0.123 0.036 0.148

psi8 -1.445 -1.864 -5.106 0.290 0.015 0.012 0.227 0.183 -0.347

psi9 1.783 1.392 2.164 -0.608 0.007 -0.483 0.335 0.308 -0.045

Asple

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.332 -0.419 -1.375 0.001 0.031 0.179 0.074 0.102 -0.104

psi2 0.056 0.091 0.177 0.012 0.005 -0.080 0.141 -0.184 0.051

psi3 -0.244 -0.119 -0.723 -0.015 0.008 0.016 0.115 0.078 0.024

psi4 0.023 -0.467 -3.680 0.159 -0.061 -0.477 -0.817 0.262 0.103

psi5 -0.380 -3.380 -8.205 0.130 0.014 0.340 -0.020 0.841 0.008

psi6 -0.361 -3.725 -1.604 0.178 -0.740 -4.643 0.004 -0.029 0.048

psi7 0.270 -1.619 -3.781 -1.926 -0.154 -1.006 -0.466 0.014 0.003

psi8 0.162 -1.084 -0.885 -2.312 0.031 0.020 0.098 0.002 0.082

psi9 -0.263 2.353 -2.638 -0.208 0.000 0.000 0.038 0.039 0.000

LysHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.014 0.003 0.003 0.000 0.000 0.004 0.029 0.000 0.000

psi2 0.003 0.002 0.017 0.000 0.000 0.010 0.005 0.000 0.000

psi3 0.004 0.037 0.242 0.208 0.047 0.000 0.000 0.000 0.000

psi4 0.016 0.333 17.454 9.079 0.000 0.000 0.000 0.002 0.000

psi5 0.023 0.474 3.585 0.200 0.000 0.000 0.010 0.014 0.000

psi6 0.006 0.295 -0.052 0.006 0.000 0.080 0.023 0.000 0.000

psi7 0.028 0.062 0.098 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.027 0.109 0.271 0.082 0.000 0.000 0.003 0.013 0.000

psi9 0.128 0.118 0.299 0.017 0.000 0.000 0.006 0.007 0.000

LysHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.044 0.028 0.156 0.000 0.000 0.003 0.043 0.012 0.000

psi2 0.000 0.125 0.004 0.000 0.000 0.119 0.024 0.000 0.000

psi3 0.001 0.401 0.796 2.159 0.005 0.000 0.001 0.000 0.000

psi4 0.000 0.253 -0.608 3.189 -1.919 0.000 0.001 0.000 0.014

psi5 0.030 1.866 3.436 1.103 0.000 0.001 -0.334 0.361 0.000

psi6 0.022 0.141 -0.746 0.000 0.000 0.250 -0.112 0.000 0.000

psi7 0.098 0.169 0.268 0.010 0.000 -0.041 0.004 0.000 0.000

psi8 0.229 0.442 0.542 0.151 0.000 0.000 0.001 0.001 0.000

psi9 0.823 0.917 0.440 0.130 0.000 0.000 0.129 0.022 0.001

Lyshe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.002 0.010 0.000 0.000 0.002 0.004 0.000 0.000

psi2 0.000 0.006 0.000 0.000 0.047 0.065 0.011 0.000 0.000

psi3 0.018 0.027 -0.561 -0.631 -1.486 0.034 0.000 0.000 0.003

psi4 0.066 0.557 -10.399 -7.700 0.094 0.000 0.002 0.000 0.000

psi5 -0.041 -0.294 -9.239 -3.049 0.000 0.003 -0.291 0.197 0.003

psi6 0.025 -0.416 0.105 0.000 0.000 0.275 0.181 0.003 0.000

psi7 0.026 -0.014 0.077 0.009 0.000 -0.002 0.000 0.000 0.000

psi8 -0.154 -0.278 -0.422 -0.016 0.000 0.003 0.000 0.000 0.000

psi9 0.007 -0.045 -0.313 0.068 0.000 0.000 0.003 0.000 0.000

LysSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.229 0.089 0.041 0.000 0.000 0.000 0.010 0.028 0.332

psi2 0.000 0.010 0.000 0.009 0.000 0.001 0.001 0.003 0.010

psi3 0.000 0.019 0.005 0.028 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.073 0.317 0.186 0.000 0.000 0.004 0.000 0.000

psi5 0.000 0.195 0.044 0.023 0.000 0.000 0.024 0.002 0.000

psi6 0.024 0.012 0.013 0.000 0.000 0.073 0.001 0.000 0.000

psi7 0.029 0.452 0.326 0.000 0.000 0.002 0.000 0.000 0.000

psi8 1.097 8.759 4.502 -0.125 0.000 0.000 0.000 0.000 0.001

psi9 3.932 6.170 2.344 0.224 0.000 0.000 0.000 0.014 0.055

LysSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.987 0.415 0.182 0.000 0.000 0.000 0.066 0.155 0.414

psi2 0.047 0.055 0.000 0.000 0.000 0.000 0.027 0.000 0.006

psi3 0.000 0.010 0.001 -0.297 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -1.296 -0.160 0.352 0.000 0.000 0.000 0.004 0.000

psi5 0.000 -0.244 -0.173 0.005 0.000 0.000 0.162 0.005 0.000

psi6 -0.180 0.041 0.023 0.000 0.000 0.210 0.208 0.000 0.000

psi7 0.083 0.041 0.215 0.000 0.000 0.023 0.167 0.000 0.161

psi8 -2.228 0.065 -0.139 0.360 0.004 0.000 0.000 0.044 0.171

psi9 0.491 -1.360 0.014 -0.155 0.000 0.000 0.037 0.229 0.105

Lysse

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.125 -0.352 0.004 0.000 0.000 0.000 0.003 0.000 0.005

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.005 0.000 0.000

psi3 0.000 0.001 0.064 -0.125 0.000 0.000 0.000 0.004 0.000

psi4 0.000 0.482 -0.468 0.032 0.004 0.000 0.021 0.000 0.000

psi5 0.044 0.044 -0.066 0.004 0.000 0.003 0.043 0.008 0.000

psi6 0.003 0.034 0.044 0.004 0.000 -0.118 0.045 0.000 0.000

psi7 -0.411 -0.613 -0.535 0.000 0.000 0.000 0.000 0.000 0.069

psi8 -1.182 -5.170 -3.870 -0.471 0.000 0.000 0.005 0.000 0.023

psi9 -1.883 -3.611 -2.161 -0.205 0.000 0.000 0.004 0.000 0.000

Lyslb

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.367 0.199 0.298 0.010 0.000 0.020 0.333 0.024 0.108

psi2 0.010 0.046 0.053 0.001 0.030 0.100 0.028 0.002 0.002

psi3 0.004 0.097 0.212 0.032 0.000 0.019 0.004 0.081 0.000

psi4 0.013 0.514 2.330 0.588 0.000 0.000 0.037 0.097 0.009

psi5 0.059 1.265 2.151 0.085 0.000 0.002 0.718 0.245 0.001

psi6 0.188 0.583 0.588 0.009 0.000 0.291 0.263 0.003 0.000

psi7 0.141 0.763 1.272 0.019 0.019 0.115 0.037 0.007 0.000

psi8 0.787 2.087 4.883 1.049 0.000 0.033 0.023 0.087 0.026

psi9 1.547 1.702 5.824 0.645 0.000 0.000 0.114 0.125 0.204

Lyslm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 1.032 0.351 -0.027 0.025 0.000 0.018 0.432 0.191 0.206

psi2 0.007 -0.008 0.105 0.006 0.001 0.016 0.437 0.009 0.003

psi3 0.162 0.303 -1.889 0.009 0.075 0.126 0.052 0.000 0.056

psi4 0.066 1.332 1.955 -0.749 -0.033 0.000 -0.302 -0.256 0.022

psi5 0.494 1.759 2.852 -2.226 0.000 0.158 2.931 0.375 0.010

psi6 0.376 1.599 -0.009 0.001 0.013 -0.875 0.646 -0.015 0.004

psi7 0.588 0.619 -0.323 0.159 0.030 -0.400 -0.235 0.013 0.046

psi8 -0.013 1.465 2.326 0.317 0.013 0.020 0.118 0.041 0.084

psi9 -1.176 0.939 6.416 0.476 0.003 0.028 0.459 0.417 0.191

Lysle

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.102 0.029 -1.407 0.001 0.047 0.243 0.451 0.008 0.037

psi2 0.078 -0.905 -0.028 0.011 0.006 0.019 1.523 0.097 -0.100

psi3 0.337 -0.199 -0.616 -0.350 -1.226 0.014 0.106 0.033 0.004

psi4 -0.834 -2.040 -8.625 -4.670 0.095 0.073 0.294 0.128 -0.073

psi5 -0.305 -2.720 -4.669 -0.049 0.007 -0.060 2.896 0.298 -0.088

psi6 -0.494 -2.335 -4.710 0.144 -0.032 -3.779 -3.945 0.302 0.035

psi7 -0.790 -1.552 -1.841 0.027 -2.051 -0.336 -0.419 0.016 0.006

psi8 -0.730 -2.252 -4.902 -3.614 0.018 -0.113 0.090 -0.136 0.104

psi9 -2.955 -5.941 -5.961 -2.661 0.000 0.000 0.050 0.212 -0.183

GluHB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.015 0.004 0.004 0.000 0.000 0.004 0.026 0.000 0.000

psi2 0.010 0.001 0.021 0.000 0.000 0.010 0.003 0.000 0.000

psi3 0.002 0.045 0.377 -0.689 0.040 0.000 0.000 0.000 0.000

psi4 0.019 0.277 8.101 7.925 0.000 0.000 0.000 0.002 0.000

psi5 0.027 0.140 2.729 -0.544 0.000 0.000 0.011 0.017 0.000

psi6 -0.089 0.242 0.128 0.007 0.000 0.017 0.021 0.000 0.000

psi7 0.108 0.035 0.012 0.000 0.000 0.001 0.000 0.000 0.000

psi8 0.127 0.126 0.381 0.076 0.000 0.000 0.004 0.013 0.000

psi9 0.003 0.030 0.424 0.019 0.000 0.000 0.008 0.009 0.000

GluHM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.017 0.030 0.160 0.000 0.000 0.004 0.085 0.048 0.000

psi2 0.000 0.001 0.175 0.000 0.000 0.025 0.017 0.000 0.000

psi3 0.001 0.029 -4.444 1.277 0.005 0.000 0.001 0.000 0.000

psi4 0.000 0.787 -6.019 -2.927 -0.084 0.000 0.001 0.000 -0.171

psi5 0.004 -0.164 -2.850 1.284 0.000 0.186 0.189 0.636 0.118

psi6 0.016 0.488 -0.228 0.000 0.000 0.132 0.135 0.000 0.000

psi7 -0.350 0.265 0.141 0.016 0.000 0.024 0.320 0.000 0.000

psi8 -0.051 0.167 0.011 -0.212 0.000 0.000 0.001 0.001 0.000

psi9 0.221 -0.855 -1.164 0.133 0.000 0.000 0.079 0.023 0.162

Gluhe

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.000 0.033 0.007 0.000 0.000 0.002 0.005 0.000 0.000

psi2 0.050 0.011 0.000 0.000 0.024 0.034 0.011 0.000 0.000

psi3 0.019 -0.224 -2.947 -0.096 0.239 0.004 0.001 0.000 0.004

psi4 -1.879 -1.330 -11.395 -6.921 0.032 0.000 0.002 0.000 0.000

psi5 0.014 0.610 -2.771 -1.133 0.000 0.003 0.081 0.011 0.005

psi6 0.072 -0.605 0.015 0.000 0.000 -0.006 0.422 0.004 0.000

psi7 0.023 0.172 0.124 0.000 0.000 0.020 0.000 0.000 0.000

psi8 0.002 -0.384 0.353 -0.276 0.000 0.005 0.000 0.000 0.000

psi9 0.009 -0.003 -0.049 -0.285 0.000 0.000 0.004 0.000 0.000

GluSB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.393 0.252 0.209 0.000 0.000 0.000 0.012 0.056 0.395

psi2 0.000 0.013 0.000 0.012 0.000 0.001 0.025 0.003 0.008

psi3 0.000 0.020 0.059 0.051 0.000 0.000 0.001 0.000 0.000

psi4 0.000 0.113 0.276 0.720 0.000 0.000 0.017 0.000 0.000

psi5 0.001 0.149 0.137 0.025 0.000 0.000 0.025 0.001 0.000

psi6 0.087 0.015 0.026 0.001 0.000 -0.011 0.001 0.000 0.000

psi7 0.030 0.318 0.589 0.000 0.000 0.003 0.000 0.000 0.000

psi8 0.357 7.712 2.568 0.165 0.000 0.000 0.000 0.000 0.001

psi9 2.818 3.583 1.777 0.057 0.000 0.000 0.001 0.030 0.167

GluSM

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.488 -0.404 0.156 0.000 0.000 0.000 0.054 0.141 0.431

psi2 0.049 0.109 0.000 0.000 0.000 0.000 0.027 0.000 0.011

psi3 0.000 0.020 0.043 -0.117 0.000 0.000 0.000 0.000 0.000

psi4 0.000 -0.289 -0.463 -0.650 0.000 0.000 0.000 0.017 0.000

psi5 0.000 0.392 0.031 0.083 0.000 0.000 0.073 0.017 0.000

psi6 0.017 0.135 0.025 0.000 0.000 0.039 0.084 0.000 0.000

psi7 0.105 0.481 0.333 0.000 0.000 0.000 0.019 0.000 0.096

psi8 -0.640 -2.653 -0.432 0.055 0.004 0.000 0.000 0.017 0.185

psi9 -0.302 -1.003 0.635 0.050 0.000 0.000 0.048 0.078 0.234

Gluse

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.070 0.113 0.004 0.000 0.000 0.000 0.003 0.000 0.194

psi2 0.000 0.000 0.000 0.000 0.000 0.000 0.018 0.000 0.000

psi3 0.000 0.005 0.017 0.123 0.000 0.000 0.000 0.017 0.000

psi4 0.000 -0.237 -1.070 -0.042 0.032 0.000 0.022 0.000 0.000

psi5 0.024 -0.246 -0.041 0.082 0.000 0.004 0.058 0.033 0.000

psi6 -0.040 -0.059 0.071 0.017 0.000 -0.323 0.064 0.000 0.000

psi7 0.091 0.341 0.088 0.000 0.000 0.000 0.000 0.000 0.086

psi8 -0.199 -3.401 -1.870 0.000 0.000 0.000 0.017 0.000 0.045

psi9 -1.017 -0.763 -1.821 -0.031 0.000 0.000 0.017 0.000 0.001

GluLB

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 0.378 0.271 0.496 0.011 0.000 0.047 0.165 0.032 0.023

psi2 0.013 0.149 0.155 0.001 0.024 0.032 0.034 0.019 0.003

psi3 0.005 0.116 0.159 0.036 0.000 0.019 0.005 0.025 0.000

psi4 0.013 0.258 1.395 0.715 0.000 0.001 0.195 0.051 0.027

psi5 0.151 1.709 2.063 -0.159 0.000 0.003 0.478 0.195 0.001

psi6 0.176 0.405 0.278 0.013 0.000 0.391 0.813 0.004 0.000

psi7 0.306 0.782 1.077 0.026 0.021 0.042 0.007 0.002 0.000

psi8 -0.200 0.219 3.846 0.784 0.000 0.035 0.127 0.101 0.027

psi9 2.348 2.434 3.475 1.084 0.000 0.000 0.233 0.225 0.452

Glulm

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 1.005 0.556 0.996 0.077 0.000 0.069 0.511 0.171 0.534

psi2 -0.089 0.102 0.207 0.019 0.001 0.143 0.106 0.014 0.064

psi3 0.101 -0.026 -0.037 -0.425 0.029 0.035 -0.031 0.000 0.024

psi4 0.045 1.203 0.506 1.330 0.016 0.000 0.114 0.112 0.027

psi5 -0.008 1.506 0.440 -0.009 0.000 -0.001 1.793 0.288 -0.191

psi6 -0.083 -0.266 0.537 0.078 -0.128 0.319 0.165 0.031 0.004

psi7 0.345 -0.073 1.726 0.276 -0.272 -0.109 -0.201 0.028 -0.049

psi8 0.328 1.547 2.077 0.378 0.017 0.019 0.793 0.036 0.147

psi9 1.653 -1.371 1.845 0.361 -0.131 0.031 0.331 0.701 -0.135

Glule

phi1 phi2 phi3 phi4 phi5 phi6 phi7 phi8 phi9

psi1 -0.029 -0.287 -0.618 0.001 0.039 0.224 -0.094 0.006 0.035

psi2 0.004 0.036 -0.665 0.015 0.005 -0.125 0.666 0.021 0.038

psi3 -0.752 -0.529 -0.191 -0.316 0.016 0.019 0.128 -0.022 0.005

psi4 0.071 -0.253 -6.457 -3.005 0.033 0.086 0.146 0.439 0.030

psi5 -0.189 -0.973 -3.949 0.139 0.154 0.275 1.576 0.238 0.009

psi6 -0.660 -1.168 -0.709 -0.055 0.011 -0.303 -0.629 0.034 0.016

psi7 -0.153 -0.632 0.615 -0.207 0.074 0.602 0.278 0.020 -0.043

psi8 -0.012 -1.948 -5.899 -1.041 -0.273 0.064 -0.532 0.001 0.097

psi9 -1.697 -4.367 -2.902 -0.764 0.000 0.000 0.035 0.053 0.049

16,290 pairwise-contact energy parameters

Cys-cys

HB HM HE SB SM SE LB LM LE

HB -3.934 -1.711 0.072 -4.660 -0.711 0.000 -6.958 -4.803 -0.394

HM -4.095 -1.393 0.046 -0.657 0.003 -1.081 -3.652 -0.146

HE 0.131 0.008 0.018 0.000 0.021 0.084 0.051

SB -4.482 -4.498 0.253 -4.919 -3.919 0.335

SM 0.324 0.185 -2.817 -2.301 -0.301

SE 0.011 0.008 0.026 0.021

LB -5.587 -5.914 -0.497

LM -7.041 -0.841

LE 0.097

Cys-phe

HB HM HE SB SM SE LB LM LE

HB -6.161 -1.828 -0.548 -1.856 0.018 0.000 -0.201 -0.328 0.040

HM 1.647 -1.485 0.053 0.035 -0.120 0.003 -0.057 0.170 0.114

HE 0.097 0.567 -0.765 0.005 0.010 0.000 0.013 0.049 0.036

SB 0.186 0.095 0.005 -1.481 -2.167 0.196 -1.534 -0.847 0.061

SM 0.018 0.034 0.010 0.404 -1.668 0.177 0.081 -0.206 0.224

SE 0.000 0.004 0.000 0.135 0.100 0.076 0.006 0.017 0.010

LB -0.803 0.186 0.013 -1.080 -0.073 0.008 -1.359 -1.429 0.204

LM -1.850 0.190 0.048 0.369 0.089 0.017 0.553 -0.863 0.561

LE 0.039 0.129 0.034 0.137 0.330 0.010 -0.399 0.542 0.273

Cys-leu

HB HM HE SB SM SE LB LM LE

HB -4.352 -2.512 0.326 -0.298 0.031 0.001 -0.868 -1.841 -0.576

HM 0.025 1.391 -1.533 0.007 -0.318 0.004 0.607 0.312 0.097

HE 0.201 1.804 -0.006 0.077 0.068 0.001 0.034 0.114 0.187

SB -0.447 0.007 0.010 -3.951 -1.014 0.398 -1.625 -0.653 0.144

SM 0.135 0.055 0.018 1.240 -2.018 0.108 0.227 0.432 0.137

SE 0.001 0.004 0.001 0.111 -0.127 0.032 0.008 0.029 0.018

LB -2.004 -1.004 -0.040 -0.874 -1.595 -0.055 -1.434 -0.922 -0.540

LM 0.662 2.070 0.726 -0.659 -0.050 0.029 0.315 0.116 0.599

LE 0.468 0.210 -0.481 0.159 0.223 0.018 0.177 0.203 0.188

Cys-trp

HB HM HE SB SM SE LB LM LE

HB 0.446 -1.741 0.023 -0.348 0.003 0.000 -1.716 -0.358 0.015

HM -0.106 0.461 0.204 0.017 -0.157 0.001 -0.657 0.074 -0.218

HE 0.392 0.547 0.185 0.001 0.172 0.000 0.005 0.015 0.009

SB 0.026 0.017 0.001 -2.401 -2.358 0.051 0.096 -0.594 0.033

SM 0.008 0.015 0.003 -0.445 0.193 0.047 0.038 0.075 0.031

SE 0.000 0.001 0.000 0.034 0.047 0.008 0.002 0.011 0.005

LB -0.731 0.038 -0.007 -0.252 0.207 0.002 -0.677 -0.559 0.070

LM 0.391 0.075 0.015 -0.368 0.253 0.010 0.189 -0.387 0.089

LE 0.016 0.032 0.008 -0.219 0.031 0.005 0.031 0.326 0.042

Cys-val

HB HM HE SB SM SE LB LM LE

HB 1.629 -1.991 -0.432 -0.062 -0.357 0.001 -0.805 -0.134 0.056

HM -1.567 0.998 0.462 -0.065 -1.238 0.004 0.210 0.465 0.260

HE 0.078 0.430 0.823 0.178 0.080 0.003 0.018 0.071 0.049

SB -0.155 -0.195 0.009 -1.293 -1.174 0.066 -0.564 -0.034 0.138

SM -0.004 -0.328 0.013 -0.545 0.196 0.241 0.487 0.229 0.165

SE 0.001 0.004 0.000 -0.059 0.331 0.066 0.009 0.028 0.015

LB -0.655 0.127 0.018 0.008 0.123 0.009 -1.643 0.234 -0.179

LM -0.080 -0.056 0.071 0.859 -0.651 -0.067 -0.236 0.201 0.595

LE 0.371 0.322 0.047 0.104 0.150 0.015 0.145 0.673 0.158

Cys-ile

HB HM HE SB SM SE LB LM LE

HB -3.138 -2.046 0.110 0.298 -0.021 0.001 -0.763 0.121 0.216

HM 2.267 -0.279 -1.399 0.032 0.041 0.003 0.055 0.001 -1.238

HE 0.232 1.438 -0.617 0.006 0.010 0.000 0.013 0.067 0.051

SB -0.539 0.035 0.006 -1.301 -1.057 0.010 -0.895 0.487 0.093

SM 0.016 0.046 0.010 0.389 -1.780 -0.033 0.130 -0.248 0.063

SE 0.001 0.003 0.000 0.108 0.381 0.024 0.005 0.046 0.011

LB -2.091 -0.075 0.014 0.214 0.240 0.005 -3.049 0.151 -0.268

LM -0.147 0.183 -0.104 -0.191 -0.016 0.019 0.434 1.014 -0.127

LE 0.303 0.174 0.108 0.062 0.096 0.011 0.124 0.253 0.136

Cys-met

HB HM HE SB SM SE LB LM LE

HB -0.939 0.595 -0.661 -0.194 -2.025 0.000 -1.665 -0.446 -0.507

HM 0.710 0.643 0.285 0.118 0.035 0.001 0.053 0.086 0.191

HE 0.140 0.658 0.096 0.002 0.005 0.000 0.005 0.027 0.016

SB 0.026 -0.389 0.002 -0.439 -2.077 -0.314 -0.367 0.003 -0.100

SM 0.009 0.013 0.005 0.224 0.287 0.120 0.034 0.092 0.035

SE 0.000 0.001 0.000 0.031 0.050 0.006 0.002 0.008 0.005

LB -0.113 0.204 0.005 0.029 0.034 0.002 0.279 -0.185 -0.516

LM -1.058 -0.861 0.027 0.139 0.095 0.007 -0.287 -1.726 0.207

LE -0.066 0.162 0.015 0.026 0.035 0.005 0.043 0.304 0.049

Cys-his

HB HM HE SB SM SE LB LM LE

HB -1.370 -1.404 -0.357 -0.326 0.013 0.000 0.023 -0.176 0.178

HM -0.293 -2.626 -0.332 0.030 0.034 0.003 -0.525 -1.104 -0.146

HE -0.089 0.223 0.579 0.005 0.012 0.000 0.012 -1.875 0.041

SB 0.044 -0.091 0.005 -0.339 -0.380 -0.818 -0.020 -0.635 0.121

SM 0.013 0.160 0.012 0.737 0.066 0.094 0.068 0.441 0.206

SE 0.000 0.003 0.000 0.083 0.096 0.017 0.004 0.012 0.008

LB -0.658 -0.172 -0.514 0.276 -0.304 0.004 -0.453 -1.362 0.162

LM 0.442 0.112 0.057 0.025 0.058 0.012 0.472 -0.575 0.114

LE 0.033 0.139 -0.507 0.047 0.182 0.008 0.093 0.145 0.107

Cys-tyr

HB HM HE SB SM SE LB LM LE

HB -1.123 -0.425 -0.433 -3.066 -0.417 0.000 -1.101 -0.183 0.035

HM 0.740 -0.533 1.304 0.033 0.050 0.002 0.791 0.291 0.140

HE 0.060 1.024 0.268 0.004 0.008 0.000 0.011 0.041 0.025

SB 0.150 -0.113 0.004 -0.299 -4.407 -0.391 -0.054 -0.311 -0.001

SM 0.014 0.034 0.007 0.537 -1.417 0.047 0.219 -0.660 0.078

SE 0.000 0.097 0.000 0.099 0.228 0.017 0.035 0.017 0.010

LB 0.204 -0.630 -0.208 0.408 -1.345 0.005 -1.215 -1.021 -1.079

LM 0.006 0.135 -0.345 -0.068 -1.398 0.026 0.533 -0.141 0.178

LE 0.079 0.410 -0.417 0.066 -0.382 0.010 0.097 0.406 0.172

Cys-ala

HB HM HE SB SM SE LB LM LE

HB -3.561 0.366 -0.235 -0.216 -0.407 0.001 -1.227 -0.828 -0.063

HM -0.130 0.772 0.924 0.242 0.060 0.047 0.765 -0.317 0.164

HE 0.117 0.524 0.892 0.006 0.013 0.000 0.018 0.088 -0.001

SB -0.661 -0.355 0.004 0.151 0.099 0.000 -0.190 -1.106 -0.214

SM 0.033 -0.544 0.013 -2.123 0.880 0.163 -0.542 0.996 -0.165

SE -0.170 -0.025 0.000 0.303 0.183 0.033 0.006 0.050 0.015

LB -0.142 -1.485 0.259 -0.238 0.274 0.006 -2.074 0.049 -0.538

LM 0.387 -0.240 0.218 -0.083 0.417 0.020 -0.083 -1.396 0.716

LE 0.193 -0.042 0.062 0.339 0.235 0.010 0.213 0.472 -0.236

Cys-gly

HB HM HE SB SM SE LB LM LE

HB -1.569 0.126 0.230 -0.385 0.027 0.001 -0.314 -0.854 -0.135

HM -0.061 -0.282 0.469 0.017 0.058 0.005 -0.367 -0.027 -0.543

HE 0.102 0.707 0.810 0.006 0.011 0.000 0.022 0.090 0.052

SB 0.016 -0.107 0.006 1.007 -0.537 -0.003 -0.203 -1.934 0.265

SM 0.079 0.058 0.011 0.815 0.635 0.288 -0.125 -0.327 -0.015

SE 0.001 0.005 0.000 0.141 0.225 0.038 0.009 0.027 -0.453

LB -0.008 0.158 -0.146 0.109 0.025 0.008 -1.706 -1.721 -0.012

LM 0.561 0.517 0.089 0.119 0.500 0.127 -0.459 -1.183 -0.308

LE 0.076 0.459 0.060 -0.199 0.170 0.019 0.100 0.606 -0.036

Cys-pro

HB HM HE SB SM SE LB LM LE

HB -1.048 -0.024 0.507 -0.608 0.238 0.001 -0.033 -0.695 -0.420

HM -0.083 1.093 -1.598 -0.336 0.037 0.003 -0.047 -0.587 0.129

HE 0.175 1.020 0.204 0.006 0.011 0.000 0.015 0.075 0.073

SB 0.381 0.037 -0.134 0.033 1.143 -0.405 -0.217 -0.201 0.075

SM 0.019 0.034 0.012 0.285 0.439 0.246 0.673 -0.260 -0.036

SE 0.000 0.003 0.000 0.184 0.158 0.039 0.006 0.023 0.015

LB 0.411 -0.676 0.015 0.141 0.004 0.006 -0.642 -1.450 0.127

LM 0.567 -0.094 0.067 0.386 0.717 0.024 0.267 0.501 -0.032

LE 0.048 0.132 0.045 0.079 0.177 0.015 0.227 0.918 -0.154

Cys-asn

HB HM HE SB SM SE LB LM LE

HB 1.834 0.626 -0.439 0.079 -0.493 0.001 -0.439 -2.866 0.164

HM 1.295 0.454 0.261 0.049 0.049 0.004 0.166 0.539 0.235

HE 0.074 0.638 0.547 0.007 0.014 0.000 0.020 0.063 0.041

SB 0.081 0.100 0.007 0.069 -1.302 -1.082 -1.736 -0.528 -1.511

SM 0.091 0.049 0.014 1.011 0.179 0.239 0.119 -0.477 -0.185

SE 0.001 0.004 0.000 0.189 0.182 0.127 0.008 0.024 0.018

LB 0.405 0.005 -0.520 0.439 0.064 0.008 -0.620 -4.240 -0.160

LM -0.443 0.303 0.062 0.458 -0.083 0.024 0.269 -0.218 0.303

LE 0.295 0.238 0.288 0.088 -0.214 0.018 0.192 0.710 -0.626

Cys-thr

HB HM HE SB SM SE LB LM LE

HB 0.774 -0.473 0.402 -0.451 -0.275 0.001 0.562 -0.568 -0.359

HM 0.610 1.815 -0.319 0.067 0.048 0.004 -0.026 0.190 0.052

HE 0.087 1.237 -0.462 0.006 0.013 0.001 0.018 0.093 0.076

SB -0.487 0.041 0.006 -0.907 -3.571 0.060 0.140 -1.771 -1.044

SM 0.024 0.045 0.013 0.899 -0.185 0.371 0.154 -0.869 0.123

SE 0.001 0.099 0.001 -0.284 0.185 0.284 0.007 0.023 0.014

LB -0.550 -0.547 0.018 -0.329 -0.228 0.125 -1.116 -0.364 -0.305

LM 0.079 0.661 0.093 0.345 -0.381 0.024 -0.578 0.099 -0.127

LE 0.087 -0.489 0.061 0.096 0.198 0.015 -0.146 -0.103 0.393

Cys-ser

HB HM HE SB SM SE LB LM LE

HB 0.505 -0.399 0.241 0.155 -0.064 0.001 0.151 -0.415 -0.875

HM -0.400 0.614 1.012 0.065 0.081 0.003 -0.429 -0.911 -0.151

HE 0.519 0.724 0.981 0.011 0.023 0.000 0.025 0.090 0.183

SB -0.148 0.065 0.011 -0.943 0.057 0.113 -0.186 -0.507 -0.049

SM 0.032 0.064 -0.153 1.431 0.346 0.191 0.418 -1.744 0.034

SE 0.001 0.003 0.000 0.524 0.445 0.188 -0.161 0.082 0.019

LB -0.374 -0.266 -0.082 -0.592 -0.478 0.011 -0.775 -1.590 -1.763

LM -0.303 -0.254 -0.246 -1.359 0.257 0.028 -0.637 -1.713 -0.815

LE 0.421 0.287 0.069 -0.211 0.171 0.019 0.248 0.629 -0.017

Cys-arg

HB HM HE SB SM SE LB LM LE

HB -0.691 -1.898 0.529 0.066 -0.309 0.001 0.464 -0.129 -1.677

HM 0.823 -0.957 -1.334 0.041 0.038 0.005 0.125 0.777 -0.120

HE 0.109 1.805 0.972 0.004 0.010 0.002 0.015 0.065 0.049

SB 0.284 0.155 -0.457 1.191 -1.165 0.189 0.084 -0.302 -0.247

SM 0.020 0.084 0.010 1.255 -0.477 -0.030 0.102 0.066 0.104

SE 0.001 0.003 0.000 0.086 0.118 0.024 0.008 0.022 0.016

LB -0.784 -1.997 0.015 -0.040 -0.371 -0.056 0.611 -1.213 -3.603

LM -0.740 1.489 0.066 0.427 -0.314 0.037 0.692 0.608 -0.171

LE 0.054 0.393 0.298 0.080 0.458 0.016 0.213 0.563 0.182

Cys-gln

HB HM HE SB SM SE LB LM LE

HB 0.813 -1.351 -0.252 0.098 -0.730 0.218 0.134 -0.051 0.036

HM 0.283 1.478 0.699 0.030 0.023 0.002 0.309 -0.058 0.121

HE 0.134 1.330 0.766 0.174 0.009 0.000 0.013 0.044 0.032

SB -0.025 -0.216 0.005 -0.619 -1.855 -0.391 -0.251 -0.161 0.046

SM 0.017 0.010 0.009 0.505 0.455 -0.165 -0.004 0.128 0.222

SE 0.001 0.002 0.000 0.064 0.226 0.019 0.006 0.017 0.011

LB 0.253 0.003 0.372 -0.050 0.266 0.006 -0.605 -0.436 -0.613

LM 0.247 0.055 0.044 0.131 -0.161 -0.037 0.159 0.125 -0.228

LE 0.042 0.577 0.036 0.215 0.075 0.011 0.351 0.447 0.098

Cys-asp

HB HM HE SB SM SE LB LM LE

HB -0.148 -1.686 -0.371 0.041 0.020 0.001 0.204 -0.735 0.015

HM -0.092 2.558 0.035 0.041 0.162 0.003 0.116 0.406 -0.007

HE 0.086 0.800 0.065 0.005 0.011 0.000 0.024 0.106 0.049

SB 0.072 0.043 0.005 0.329 -0.585 -0.182 0.176 -0.323 -1.904

SM 0.021 0.044 0.011 0.430 1.011 0.104 0.358 0.538 0.275

SE 0.001 0.003 0.000 0.082 0.148 0.023 0.259 0.020 0.012

LB -0.726 -0.103 -0.122 -0.516 -0.202 -0.097 -0.075 -3.544 -0.972

LM 0.465 0.166 0.078 0.629 0.287 0.022 0.435 -0.048 0.503

LE 0.058 0.438 0.050 0.092 0.095 0.012 0.134 0.732 0.149

Cys-lys

HB HM HE SB SM SE LB LM LE

HB 1.604 0.018 -1.664 0.199 0.136 -0.066 0.386 -0.867 -0.928

HM 1.596 1.906 1.217 0.048 0.070 0.006 0.186 -0.438 -1.873

HE 0.095 0.214 1.946 0.058 0.025 0.000 0.018 0.102 0.099

SB 0.072 -0.029 0.008 0.668 -2.607 -1.436 0.371 -1.625 0.012

SM 0.021 0.060 0.014 0.590 0.513 0.045 0.151 0.023 0.024

SE 0.001 0.006 0.000 0.094 0.265 0.029 0.008 0.027 0.017

LB 0.373 -0.156 -0.180 0.412 -0.902 -0.195 0.773 0.030 -3.312

LM -0.654 -0.038 0.087 0.417 0.625 0.028 0.842 2.238 -0.644

LE 0.068 0.855 0.399 0.143 0.401 0.017 0.187 0.761 0.444

Cys-glu

HB HM HE SB SM SE LB LM LE

HB 0.451 -0.522 0.150 0.216 0.018 0.001 0.532 -0.194 -0.567

HM -0.054 0.360 0.082 0.042 0.042 0.004 0.115 0.232 -3.317

HE 0.094 1.385 0.953 0.008 0.014 0.001 0.018 0.170 0.434

SB 0.109 0.014 0.008 1.052 -1.506 -1.348 0.191 -0.480 0.010

SM 0.019 -0.128 0.259 1.186 0.483 0.021 0.146 -1.104 0.438

SE 0.001 0.004 0.001 0.101 0.155 0.026 0.008 0.023 0.012

LB 0.382 -1.248 -0.387 -0.725 -0.488 0.171 0.499 -0.519 -1.750

LM 0.230 0.240 0.195 0.268 0.334 -0.362 0.595 0.947 0.316

LE 0.125 0.229 0.308 0.079 0.256 0.012 0.157 0.537 0.162

Phe-Phe

HB HM HE SB SM SE LB LM LE

HB -0.403 -2.603 -0.159 0.127 0.032 0.002 -1.559 -0.189 0.290

HM 0.491 0.133 0.025 0.037 0.006 -0.111 -0.447 0.407

HE 0.296 0.005 0.010 0.000 0.022 0.072 0.049

SB -1.870 -2.960 0.313 0.005 0.363 -0.369

SM 0.151 0.300 -0.018 0.197 0.126

SE 0.031 0.011 0.035 0.016

LB -1.763 1.646 0.002

LM -0.690 0.650

LE 0.086

Phe-Leu

HB HM HE SB SM SE LB LM LE

HB -6.364 -2.958 -1.591 -0.501 0.119 0.005 -3.368 -0.059 0.036

HM -2.391 -4.499 2.651 0.139 0.037 0.011 0.004 -0.596 -0.022

HE -0.043 2.666 1.778 0.011 0.018 0.002 -0.014 0.066 0.123

SB -0.254 0.404 -0.143 -6.586 -1.777 0.821 -1.730 0.004 0.039

SM 0.423 0.154 -0.072 -1.116 -2.494 0.409 0.305 0.005 0.200

SE 0.004 0.010 0.002 -0.201 0.590 0.122 0.155 -0.379 0.026

LB -2.692 0.018 0.129 -0.086 -0.048 0.035 0.083 -0.028 0.284

LM -1.162 -2.035 0.212 0.449 -0.038 0.060 -0.213 1.137 0.766

LE 0.294 0.816 -0.200 -0.197 0.291 0.026 0.365 0.904 -0.474

Phe-Trp

HB HM HE SB SM SE LB LM LE

HB -1.420 0.247 -0.311 0.047 0.009 0.001 0.093 0.130 0.118

HM -0.472 -0.221 -0.827 0.022 0.020 0.002 0.068 0.029 -0.131

HE 0.040 0.184 0.278 0.002 0.005 0.000 0.007 0.028 0.016

SB 0.169 0.022 0.002 -3.496 -1.720 -0.076 -0.606 0.148 0.135

SM 0.013 0.021 0.005 -1.959 -2.581 0.343 0.059 -0.409 -1.078

SE 0.000 0.002 0.000 0.076 0.304 0.027 0.004 0.020 0.008

LB -0.504 -0.244 0.007 0.092 0.035 0.004 -1.089 -0.111 -0.110

LM 0.024 0.231 0.028 -0.124 -0.272 0.020 0.399 0.687 0.776

LE 0.031 0.095 0.016 0.127 0.055 0.008 0.059 -0.244 -0.194

Phe-Val

HB HM HE SB SM SE LB LM LE

HB -4.879 -0.141 0.233 -1.428 -0.979 0.003 -0.769 0.851 0.083

HM -1.075 -2.824 2.171 -0.747 0.282 0.011 0.204 0.201 -0.311

HE 0.193 0.783 0.401 0.012 0.018 0.001 0.030 0.132 0.099

SB -0.153 -0.715 0.013 -6.987 -0.711 0.586 -1.516 -1.932 -0.050

SM 0.436 -0.022 0.020 -0.857 -4.724 -0.779 -0.245 0.092 0.432

SE -0.079 0.011 0.001 0.591 -0.505 0.171 0.020 0.062 0.029

LB -1.275 0.239 0.030 -1.622 0.271 0.020 -1.930 -0.413 0.196

LM 0.487 -0.937 0.019 0.085 -0.127 0.063 0.201 0.369 0.520

LE 0.704 -0.020 0.114 0.191 0.244 0.029 0.250 0.668 0.038

Phe-Ile

HB HM HE SB SM SE LB LM LE

HB -0.374 0.190 0.459 0.073 -0.177 0.003 0.021 -0.532 -0.234

HM -2.646 -2.910 -0.428 -0.648 -0.223 0.008 0.204 -0.391 0.321

HE 0.457 0.316 -0.332 0.010 0.012 0.001 0.020 0.087 -0.332

SB -0.601 -0.308 0.006 -6.366 -3.129 -0.332 -0.839 -0.216 0.313

SM -0.173 0.047 0.014 -1.662 -0.347 -1.145 -0.328 0.624 -0.153

SE 0.003 0.007 0.001 -0.054 0.159 0.100 0.010 0.042 -0.566

LB -1.628 -0.003 0.021 -1.000 0.426 0.010 -2.810 0.331 0.013

LM -0.144 0.296 0.090 1.345 0.731 0.084 -0.328 1.167 0.859

LE 0.078 0.141 0.176 0.325 0.168 0.020 0.371 0.756 0.223

Phe-Met

HB HM HE SB SM SE LB LM LE

HB -1.338 -0.043 0.067 -0.472 -0.094 0.001 0.074 -0.103 0.174

HM -0.187 -2.647 1.010 0.021 0.065 0.004 -0.976 0.617 -1.392

HE 0.068 -2.933 0.481 0.003 0.006 0.000 0.009 0.044 0.030

SB -0.445 0.051 0.003 -3.295 -0.955 0.136 0.352 -1.257 0.038

SM 0.008 0.039 0.006 0.724 -0.551 0.005 -0.140 0.324 0.173

SE 0.001 0.002 0.000 0.383 -0.021 0.029 0.005 0.019 0.009

LB -0.237 0.017 0.008 -0.578 -0.464 0.005 0.409 -0.404 -0.068

LM 0.322 -0.091 0.048 -0.220 -0.081 0.017 0.543 0.610 -1.517

LE 0.032 0.129 0.031 0.151 0.050 0.009 0.225 0.220 0.090

Phe-His

HB HM HE SB SM SE LB LM LE

HB -0.872 -2.668 -1.086 0.054 -0.719 0.001 -0.117 -0.963 0.046

HM 0.420 0.711 0.457 0.024 0.027 0.004 0.186 0.048 0.045

HE 0.179 1.166 0.290 0.004 0.008 0.000 0.012 0.087 0.042

SB -0.668 0.255 -0.109 0.683 -2.350 -0.255 0.060 -0.019 -0.026

SM 0.175 0.028 0.008 -0.022 -0.047 0.110 -0.026 -0.354 -0.049

SE 0.001 0.004 0.000 0.161 0.024 0.027 0.006 0.016 0.007

LB 0.269 -0.637 0.012 -0.128 -0.470 0.006 0.131 -0.288 0.114

LM -0.230 -0.658 0.052 0.250 0.404 0.017 0.492 0.401 0.354

LE 0.047 0.319 0.040 0.058 0.031 0.081 0.157 -0.046 0.135

Phe-Tyr

HB HM HE SB SM SE LB LM LE

HB -3.896 -1.097 -0.061 -0.064 -0.503 0.002 -0.290 -2.117 0.338

HM 0.531 -0.006 -1.857 -0.328 0.074 0.003 -0.276 0.282 0.165

HE 0.314 0.913 -1.762 0.005 0.008 0.000 0.017 -0.158 0.329

SB -0.105 -0.647 0.004 -2.546 -3.457 0.018 -0.758 0.040 0.090

SM 0.024 -0.387 0.008 -0.680 -3.227 0.316 0.236 0.092 0.121

SE 0.003 0.003 0.000 0.134 0.169 0.078 0.009 0.037 0.023

LB -1.475 -0.349 0.082 -0.442 -0.342 0.009 -1.127 -0.033 0.465

LM 0.300 0.367 0.068 -0.060 -0.027 0.038 0.463 -0.667 0.334

LE 0.208 -0.197 -0.370 0.100 -0.370 0.023 0.143 0.767 0.183

Phe-Ala

HB HM HE SB SM SE LB LM LE

HB -5.967 -1.107 0.541 -0.600 0.057 0.003 -0.021 0.261 -0.066

HM -2.375 -0.012 0.551 -0.777 0.081 0.008 -0.247 0.671 -0.216

HE 0.376 0.024 0.815 -0.571 0.039 0.001 0.032 0.226 -0.594

SB -0.728 -0.073 0.009 -1.879 0.392 -0.871 -0.986 -0.066 0.350

SM -0.123 -0.332 0.018 -2.222 1.228 0.099 0.170 0.448 0.171

SE 0.003 0.008 0.001 0.172 0.416 0.141 0.035 0.053 0.030

LB -2.040 0.025 -0.343 -1.701 0.712 0.018 0.356 0.040 0.011

LM -0.095 -1.045 -0.086 -0.214 0.515 0.053 -0.048 0.283 0.988

LE 0.472 0.469 0.137 0.175 0.315 0.030 0.226 1.014 0.483

Phe-Gly

HB HM HE SB SM SE LB LM LE

HB -0.012 1.125 0.020 -0.010 0.145 0.007 -0.101 0.146 -2.142

HM -1.222 0.589 0.658 0.162 0.064 0.010 0.124 -3.445 -0.729

HE -0.894 0.723 0.391 0.007 0.014 0.001 0.128 0.277 0.171

SB -0.037 0.073 0.009 -3.101 0.043 0.448 -2.106 0.160 -0.788

SM 0.088 0.077 0.014 -2.825 1.200 1.020 -0.201 -0.352 0.328

SE 0.002 0.010 0.001 -0.617 -0.202 0.171 0.017 0.062 0.035

LB -0.816 -0.969 0.031 0.076 0.393 0.110 -2.539 -1.430 0.428

LM -0.069 -0.407 0.229 0.327 0.718 0.063 0.088 0.480 -0.268

LE 0.154 0.529 0.439 -0.048 0.135 0.035 -0.234 1.149 0.294

Phe-Pro

HB HM HE SB SM SE LB LM LE

HB 1.201 -1.359 -0.323 0.287 0.033 0.003 -0.090 -0.134 0.190

HM 1.532 1.309 1.018 0.052 -0.268 0.007 -0.483 -0.033 -0.540

HE 0.136 0.768 0.479 0.007 0.013 0.000 0.023 0.402 0.059

SB 0.068 0.078 0.007 2.630 0.350 0.520 -0.884 -0.972 -0.728

SM 0.350 0.046 0.014 1.570 1.084 -0.311 0.388 -1.140 -0.284

SE 0.002 -0.077 0.000 0.220 0.325 0.128 0.013 -0.421 -0.114

LB 0.200 -0.188 0.069 -0.042 0.158 -0.135 0.434 -2.862 -0.533

LM 0.503 0.406 0.117 -0.378 0.687 0.129 0.762 -0.446 0.697

LE 0.074 -0.128 0.060 0.111 0.270 0.018 0.362 0.912 -0.057

Phe-Asn

HB HM HE SB SM SE LB LM LE

HB 2.387 0.024 -0.262 0.023 0.270 0.002 -0.279 -0.609 -0.043

HM -0.528 0.255 1.063 0.241 0.055 0.007 0.085 -1.004 -0.666

HE 0.127 1.402 -0.732 0.008 0.016 0.001 0.119 -0.032 0.024

SB 0.138 -0.204 0.010 1.067 -0.838 -0.206 -0.036 0.252 -0.876

SM 0.041 -0.321 -0.081 0.862 0.357 -0.293 0.047 0.267 0.236

SE 0.002 0.144 0.001 0.324 -0.318 0.358 0.013 0.291 0.054

LB -0.489 -0.979 0.035 -0.033 0.094 0.013 -1.672 -0.308 0.267

LM 0.468 0.125 0.866 0.409 0.172 0.054 1.051 1.515 -0.064

LE 0.121 -0.065 0.080 -0.576 0.161 0.025 -0.283 0.335 -0.562

Phe-Thr

HB HM HE SB SM SE LB LM LE

HB -0.059 -1.313 -0.218 0.044 -0.929 0.002 0.389 -0.654 0.118

HM -0.577 -0.360 1.625 0.048 0.216 0.006 0.039 -0.710 0.178

HE -0.072 1.492 0.437 0.007 0.029 0.001 0.025 0.202 0.075

SB 0.070 0.053 0.008 0.217 0.452 -0.717 0.182 -0.978 -0.251

SM 0.040 -0.153 0.013 -1.176 -1.165 -2.640 0.485 -0.292 -0.066

SE 0.003 0.009 0.001 0.423 0.082 -0.378 0.014 -0.133 0.041

LB 0.399 -0.264 0.025 -0.368 0.087 0.125 0.506 -1.024 0.775

LM -0.150 0.054 -0.599 0.254 -0.784 0.044 0.309 0.118 -0.161

LE 0.237 0.299 0.158 -0.532 -0.628 0.025 0.337 0.545 0.610

Phe-ser

HB HM HE SB SM SE LB LM LE

HB -1.300 -0.033 -1.104 0.980 -0.940 0.003 -1.144 -0.899 -0.008

HM 0.752 -0.408 3.429 0.152 0.080 0.016 -0.200 -0.517 -0.975

HE 0.220 -1.155 3.005 0.012 0.024 0.001 0.033 0.135 0.490

SB -1.295 -0.039 0.011 -0.193 -0.767 -1.062 0.308 -0.681 -0.685

SM -0.066 0.072 0.022 0.197 0.473 0.180 -0.675 -1.075 -0.135

SE 0.004 0.008 0.001 -0.613 0.444 0.101 0.018 0.062 0.033

LB -1.225 0.507 0.320 0.602 0.014 0.019 0.295 0.317 0.573

LM 0.272 -0.752 -0.278 0.588 -0.226 0.063 1.411 -0.470 0.847

LE -0.655 0.946 -0.062 0.058 -0.965 0.032 0.164 1.289 0.512

Phe-Arg

HB HM HE SB SM SE LB LM LE

HB 2.164 -3.043 -0.609 0.324 0.162 0.002 0.454 -0.762 -0.394

HM 0.636 -0.340 1.031 0.056 -0.116 -0.365 0.364 0.398 0.327

HE 0.350 1.312 1.370 0.005 0.013 -0.923 0.023 0.093 0.175

SB 0.151 0.370 -0.016 1.408 -2.326 -0.194 1.036 -1.544 -0.655

SM 0.036 0.048 0.013 0.919 0.608 -0.604 0.447 0.180 -0.206

SE 0.002 0.007 0.001 0.285 0.508 -0.527 0.015 0.153 0.023

LB -0.332 -0.741 -0.081 0.301 -0.959 0.010 0.468 -0.631 -0.022

LM 1.000 -1.569 -0.573 0.471 -0.264 0.048 0.840 -1.045 -0.452

LE 0.055 -0.282 0.234 0.150 -0.115 0.023 0.190 0.361 0.253

Phe-Gln

HB HM HE SB SM SE LB LM LE

HB 0.782 -2.898 -0.867 0.080 0.027 0.002 0.519 0.401 -0.027

HM 0.097 -1.905 0.866 0.030 0.032 0.038 0.378 0.021 0.357

HE 0.322 -0.212 1.516 0.007 0.010 0.001 0.019 0.030 0.037

SB 0.266 -0.114 0.007 0.685 -1.239 -0.043 0.153 -0.292 -0.436

SM 0.072 0.028 0.009 0.405 -2.102 -1.067 0.391 0.303 -0.649

SE 0.002 0.005 0.001 0.529 0.201 0.057 0.009 0.029 0.018

LB -0.237 -0.649 0.019 0.165 0.109 0.011 0.880 -0.355 -0.308

LM 0.343 0.152 0.883 0.138 -0.021 0.045 0.384 0.778 -1.839

LE -0.334 0.303 0.352 0.082 0.131 0.018 0.326 0.261 0.564

Phe-Asp

HB HM HE SB SM SE LB LM LE

HB 1.767 0.097 -0.479 0.156 -0.005 0.003 -0.788 -1.016 0.088

HM 0.635 1.312 0.531 0.064 0.013 0.006 0.216 0.281 -0.655

HE 0.090 0.130 1.401 0.009 0.015 0.000 0.025 0.130 0.111

SB 0.398 -0.906 0.007 1.625 1.423 0.207 0.987 -0.335 -0.563

SM 0.072 0.067 0.016 0.041 0.537 -0.173 0.449 0.436 -0.007

SE 0.003 0.009 0.000 0.347 0.489 -0.003 0.013 0.002 0.025

LB 0.381 0.065 0.585 0.155 0.159 0.055 0.198 -1.168 0.193

LM 0.342 -1.656 -0.482 0.490 0.423 0.057 1.439 -0.634 0.509

LE 0.144 -0.116 0.082 0.192 0.176 0.025 0.198 -0.035 0.186

Phe-Lys

HB HM HE SB SM SE LB LM LE

HB 3.992 -4.840 -1.883 0.243 -0.083 0.006 0.620 -0.539 -0.830

HM 1.679 -1.728 -0.112 0.062 -0.239 0.007 0.409 1.301 -0.835

HE 0.164 1.565 2.156 0.007 0.015 0.001 0.024 0.116 0.087

SB 0.525 -0.416 0.008 3.483 -1.070 -0.359 1.561 -0.020 -1.353

SM 0.045 0.338 -0.168 0.530 -0.295 -0.610 0.390 0.400 -0.385

SE 0.003 0.008 0.001 0.243 0.084 0.078 0.012 0.253 0.082

LB 0.080 -0.248 -0.401 0.568 -0.048 0.009 1.158 -3.831 0.003

LM 0.777 -1.169 0.010 0.398 0.010 0.050 1.105 1.383 -2.191

LE 0.100 0.561 0.194 0.122 0.351 0.023 0.214 0.338 0.237

Phe-Glu

HB HM HE SB SM SE LB LM LE

HB 1.919 -1.357 0.604 0.254 0.117 0.003 0.633 0.126 -0.157

HM -0.931 -1.624 0.721 0.064 0.061 0.010 0.598 0.008 -0.086

HE 0.213 0.962 1.574 -0.571 0.016 0.001 0.027 0.143 0.090

SB -0.421 -0.111 -0.180 0.496 -3.948 -0.405 0.934 -0.418 0.482

SM 0.044 0.056 0.015 1.792 0.057 -0.525 0.314 0.369 -0.231

SE 0.003 0.034 0.001 0.409 0.543 0.251 0.018 0.047 0.022

LB -0.363 -1.593 -0.109 -0.833 0.093 0.017 2.055 0.328 0.572

LM 0.213 -0.979 -1.186 0.402 0.079 -0.165 1.142 0.517 0.378

LE 0.108 0.690 0.333 -0.253 0.343 0.022 0.261 0.572 0.278

Leu-leu

HB HM HE SB SM SE LB LM LE

HB -6.031 -1.034 -0.244 -3.161 0.226 0.009 -4.736 -2.353 2.504

HM 1.177 -2.663 -0.851 0.211 0.020 0.362 -1.891 -0.555

HE -3.012 -0.083 0.033 0.007 0.116 0.444 0.113

SB -5.670 -1.684 1.313 0.060 0.326 0.290

SM 0.562 0.468 0.283 -0.419 0.038

SE 0.224 0.088 0.105 0.043

LB -0.704 0.927 0.960

LM 1.728 1.404

LE 0.425

Leu-Trp

HB HM HE SB SM SE LB LM LE

HB -2.223 -1.334 0.836 0.297 -0.084 0.001 -0.561 0.018 -0.005

HM -0.639 -1.247 0.328 0.080 0.083 0.004 0.064 0.033 -0.156

HE 0.367 -0.325 0.844 0.004 0.008 0.001 0.015 0.062 0.118

SB 0.050 -0.164 0.004 -1.045 -1.394 0.346 -0.517 0.168 0.100

SM 0.025 0.035 0.008 -0.080 -0.544 -0.008 -0.063 -0.230 0.082

SE 0.001 0.003 0.001 0.117 0.242 0.084 0.007 0.031 0.012

LB -1.481 -0.460 0.016 0.063 -0.355 0.007 -1.035 0.637 -0.041

LM 0.178 0.435 0.419 -0.793 -2.652 -0.198 0.177 0.847 0.559

LE 0.142 0.310 -0.363 -0.022 0.339 0.124 0.099 0.263 0.146

Leu-val

HB HM HE SB SM SE LB LM LE

HB -7.056 1.095 0.830 -2.204 0.298 0.007 -0.547 0.572 0.273

HM -0.368 0.895 1.435 -1.182 0.393 0.017 -0.150 0.279 -0.087

HE 0.641 -3.252 -0.668 -0.075 0.166 0.003 -0.013 -0.592 0.028

SB 0.749 -0.805 0.024 -8.608 -1.613 -0.354 -1.067 -1.418 -0.659

SM -0.019 0.180 0.029 -1.877 -2.380 0.053 -0.314 0.120 0.693

SE 0.006 -0.239 0.003 0.329 -0.615 0.135 0.033 0.201 0.042

LB -0.869 0.503 0.060 -1.893 -0.489 0.069 -2.385 -0.347 0.426

LM -2.781 -0.057 0.248 -1.425 -0.702 -0.353 -0.260 -0.398 0.682

LE -0.041 -1.544 0.241 0.134 0.039 0.043 -0.157 -0.170 -0.187

Leu-ile

HB HM HE SB SM SE LB LM LE

HB -5.982 0.845 0.986 0.489 0.318 0.005 -3.973 -0.317 0.449

HM -5.399 1.552 -1.788 -1.341 0.024 0.013 -3.787 -1.062 0.325

HE 0.381 -2.353 -3.066 0.021 0.021 0.004 0.206 -0.375 0.287

SB 0.004 -0.202 0.035 -8.068 -3.976 -0.616 -0.539 -0.258 -0.235

SM -0.057 0.094 0.023 -1.874 -1.275 0.598 -0.134 1.109 0.217

SE 0.007 0.013 0.004 0.650 0.320 0.060 0.049 0.075 0.028

LB -1.209 -1.558 0.045 -0.771 0.334 -0.067 -1.369 0.903 0.152

LM -3.414 -0.069 0.377 1.230 0.537 0.072 -0.596 3.625 0.861

LE 0.328 0.543 0.276 0.094 0.342 0.028 0.374 1.016 0.603

Leu-Met

HB HM HE SB SM SE LB LM LE

HB -4.654 -2.397 0.425 0.563 0.028 0.002 -0.953 0.499 -0.207

HM -1.118 -2.167 -0.990 0.156 -0.438 0.004 -0.078 0.696 0.350

HE 0.274 -1.531 0.805 0.006 0.009 0.001 0.017 0.180 0.519

SB -0.180 -0.026 0.007 -1.747 -2.010 -0.329 0.243 -0.198 0.153

SM 0.026 0.046 0.010 -0.594 -0.895 0.231 0.533 0.081 0.218

SE 0.002 0.005 0.001 -0.052 -0.080 0.047 0.008 0.072 -0.054

LB -1.707 0.437 0.112 -0.093 -0.472 0.009 -0.138 -0.743 0.220

LM -0.706 0.976 0.085 0.410 0.119 0.033 1.160 0.264 0.323

LE 0.312 -0.266 0.008 0.235 0.025 0.012 0.107 0.276 0.193

Leu-his

HB HM HE SB SM SE LB LM LE

HB 2.162 -2.226 0.315 0.251 0.032 0.002 0.900 0.044 -1.108

HM 0.150 -0.707 -0.983 0.092 0.111 0.008 -2.493 0.665 -1.740

HE 0.223 2.045 -0.820 0.007 0.013 0.001 0.024 0.241 0.136

SB -0.275 -0.021 0.007 -0.658 -3.809 -0.289 0.263 -0.875 0.127

SM 0.048 0.048 -0.047 0.650 -1.412 0.040 -0.130 0.338 0.051

SE 0.002 0.006 0.001 0.459 0.027 0.059 0.010 0.029 -0.049

LB -0.500 0.044 0.025 0.846 0.253 0.010 0.874 -0.063 -0.224

LM -0.444 0.289 0.356 0.216 -0.878 0.030 0.380 -0.350 0.097

LE 0.431 -1.250 0.066 0.548 -1.049 0.014 0.345 0.461 0.282

Leu-tyr

HB HM HE SB SM SE LB LM LE

HB -5.502 -3.942 0.008 -0.491 -1.167 0.003 -1.146 -0.722 -0.349

HM -0.787 -5.703 0.472 0.083 0.051 0.006 -0.078 0.082 0.350

HE 1.047 1.313 0.017 0.010 -0.035 0.001 0.055 -0.141 -0.337

SB -1.298 -0.035 0.011 -2.451 -4.943 0.471 -0.535 0.502 0.175

SM 0.258 -0.310 0.014 -0.110 -1.285 -1.751 0.030 -0.240 0.008

SE 0.003 0.007 0.001 -2.059 -0.265 0.102 0.015 0.059 0.026

LB 0.340 -1.517 0.063 -0.391 -0.601 0.086 0.810 -1.434 -0.010

LM -1.943 -0.806 0.197 0.018 -1.858 0.057 0.314 1.152 0.111

LE -0.203 0.169 -0.197 0.191 0.359 0.026 0.278 0.155 0.323

Leu-ala

HB HM HE SB SM SE LB LM LE

HB -7.009 1.621 -0.209 0.186 0.524 0.006 -0.687 -1.543 0.466

HM -5.463 -2.007 -2.021 -0.099 0.039 0.015 0.543 -1.209 0.168

HE -1.809 -1.637 1.847 0.019 0.029 0.002 0.006 -0.484 0.166

SB -0.219 -0.493 -0.077 -3.015 0.207 -0.875 0.107 0.545 0.109

SM -0.860 0.378 -0.066 -1.903 -0.112 0.219 -0.006 0.247 -0.024

SE 0.008 0.015 0.002 -0.942 0.199 0.164 0.035 -0.007 0.044

LB -2.520 -2.987 0.052 0.025 -0.266 -0.149 -0.349 -1.146 0.350

LM -1.669 0.680 1.092 0.466 -0.513 0.089 1.125 1.994 0.625

LE -1.658 0.177 0.323 -0.035 0.013 0.044 0.064 -0.267 0.268

Leu-gly

HB HM HE SB SM SE LB LM LE

HB -0.804 2.105 0.552 -1.124 0.084 0.007 -1.196 -1.704 -0.319

HM -0.655 3.806 4.233 0.228 0.019 0.018 0.098 -1.884 -1.666

HE -0.083 1.337 2.237 -0.033 0.023 0.003 0.305 -0.348 -1.638

SB 0.236 -0.021 0.071 -0.636 2.910 1.025 -0.510 -0.559 0.032

SM 0.139 0.044 0.073 -0.760 2.412 0.977 -0.793 -0.363 0.511

SE 0.005 0.019 0.003 -0.468 1.029 0.050 0.031 -0.048 0.037

LB 1.047 -0.258 0.062 -3.939 0.760 0.031 -0.168 0.122 0.594

LM -2.213 -0.365 0.116 0.428 0.936 0.131 -0.069 1.760 -0.651

LE 0.130 0.526 0.205 0.507 0.300 0.045 0.757 0.296 -0.596

Leu-pro

HB HM HE SB SM SE LB LM LE

HB 5.306 1.896 -0.550 -0.082 -0.274 0.004 -0.622 -0.008 0.053

HM 1.915 3.295 1.054 0.102 0.041 0.011 -0.319 0.814 1.224

HE 0.222 2.274 0.400 0.013 -0.063 0.002 0.046 0.736 0.136

SB 0.498 -0.413 0.208 3.449 2.747 -0.572 0.551 -0.760 -0.467

SM -0.156 0.076 0.022 2.455 2.757 0.052 -0.078 -0.704 -0.824

SE 0.003 0.011 0.002 0.422 0.144 0.178 0.026 0.073 0.031

LB -0.625 -0.574 0.046 0.326 0.029 0.102 0.569 0.588 0.554

LM 0.556 0.452 0.792 0.858 -0.056 -0.356 1.995 1.393 -0.224

LE 0.181 0.367 -0.646 0.415 0.283 0.031 0.131 0.350 0.000

Leu-asn

HB HM HE SB SM SE LB LM LE

HB 3.120 2.108 1.551 0.778 0.158 0.004 0.297 -3.633 0.244

HM 1.431 -0.411 -0.051 0.106 -0.368 0.011 -0.912 0.745 -1.113

HE 0.386 1.981 -4.403 0.015 0.024 0.002 0.068 -1.284 -4.548

SB 0.350 -0.437 0.014 1.921 -0.067 -0.858 0.811 0.078 -0.709

SM 0.066 -0.834 0.024 2.632 3.014 -0.849 -0.920 -0.590 -2.081

SE 0.004 0.010 -0.312 0.398 -0.157 -0.122 0.018 -0.589 0.034

LB -0.226 -0.300 0.216 1.007 -0.219 -0.084 1.630 -0.277 -0.318

LM 0.522 -2.192 -0.409 0.542 -0.394 0.267 0.759 -1.587 0.893

LE -0.060 -0.847 0.145 0.337 0.548 0.034 -0.095 0.899 0.751

Leu-Thr

HB HM HE SB SM SE LB LM LE

HB -2.721 -0.698 -0.657 0.935 -0.380 0.006 1.082 -2.130 -0.114

HM -2.639 2.464 0.485 -0.052 -0.350 0.014 0.607 0.128 0.141

HE -0.447 3.637 3.997 0.014 0.149 0.005 0.053 0.309 0.183

SB 0.315 0.419 0.017 1.058 -3.404 -0.998 -0.824 -1.827 -0.080

SM 0.141 0.232 0.052 1.255 -0.438 -1.365 -0.328 -0.741 0.488

SE 0.005 0.060 0.005 0.046 0.661 0.252 0.023 -0.092 0.034

LB -0.888 -0.618 0.117 -0.270 -0.185 0.023 0.351 -1.344 0.806

LM -0.670 0.914 0.407 -0.361 -0.786 -0.163 0.043 1.700 0.373

LE 0.311 0.649 0.067 -0.249 -0.723 0.145 0.410 1.115 0.009

Leu-ser

HB HM HE SB SM SE LB LM LE

HB -0.046 -0.487 0.696 0.570 -1.840 0.006 1.404 -0.787 0.348

HM 0.274 -0.205 4.665 0.134 0.141 -0.089 0.406 -1.975 2.149

HE 0.697 0.588 -3.794 0.139 -0.066 0.245 -0.161 -0.154 -1.038

SB -0.357 0.169 -0.373 1.585 -1.248 -0.770 0.533 0.757 -0.015

SM -0.027 0.305 0.038 0.316 -0.738 0.330 -0.580 0.129 0.077

SE 0.006 0.015 0.002 0.475 0.704 0.204 0.246 0.173 0.039

LB -1.546 0.473 0.214 0.896 -0.298 0.039 -1.209 0.637 0.818

LM 0.761 0.299 0.488 -0.924 0.966 0.278 1.419 -0.957 0.648

LE -0.433 -1.598 0.298 -0.104 0.122 0.046 0.001 0.959 -0.292

Leu-arg

HB HM HE SB SM SE LB LM LE

HB 4.253 -4.270 -2.001 0.766 0.344 0.004 0.948 -0.894 -1.642

HM 2.603 -2.774 -3.597 -0.022 0.063 -0.015 0.889 1.427 0.196

HE 0.383 4.469 -2.080 0.015 0.023 0.003 0.045 -0.077 0.295

SB 0.237 0.427 -0.084 3.933 -4.982 -2.908 1.103 0.083 -0.302

SM 0.067 -0.060 -0.045 3.414 0.174 -0.509 0.348 -0.829 -0.512

SE 0.004 0.059 0.003 0.501 0.410 0.261 0.277 0.228 -0.171

LB -0.129 -1.700 -0.362 0.547 -0.894 -0.712 2.087 -0.297 -0.021

LM 0.222 -0.937 0.051 0.329 -1.744 0.081 2.336 0.243 0.245

LE 0.096 0.619 0.678 0.189 -0.033 0.138 0.450 0.119 -1.896

Leu-Gln

HB HM HE SB SM SE LB LM LE

HB 2.268 -1.808 -0.934 0.944 -0.536 -0.135 1.123 -0.761 -0.807

HM -0.262 -2.449 -1.702 0.117 -0.369 0.154 0.988 0.623 0.040

HE 0.177 0.225 -0.423 0.010 -0.089 0.003 0.131 0.446 -0.443

SB -0.093 -0.158 0.010 2.554 -0.864 -1.279 0.549 -0.120 0.188

SM -0.015 0.172 0.015 -0.486 -0.895 -1.074 0.360 -0.665 -0.735

SE 0.004 0.009 -0.311 0.464 0.900 0.136 0.045 0.048 0.024

LB 0.469 -1.638 -0.276 0.133 -0.633 0.085 2.431 0.033 0.062

LM 0.480 -0.555 0.150 0.347 0.501 -0.004 1.697 0.112 -0.077

LE 0.242 0.718 0.338 0.103 0.697 -0.021 0.130 0.966 0.029

Leu-Asp

HB HM HE SB SM SE LB LM LE

HB 1.924 1.262 0.513 0.731 -0.027 0.005 0.742 0.437 1.365

HM 2.044 2.420 -2.463 0.552 -1.298 0.091 0.976 -0.116 0.035

HE 0.706 -0.234 2.070 0.141 0.026 0.001 0.221 0.490 0.274

SB 0.199 -0.322 -0.050 2.145 2.345 0.237 0.641 -0.668 -0.574

SM 0.074 -0.201 0.103 1.754 3.787 0.218 0.467 0.412 -1.715

SE 0.005 0.010 0.001 0.448 0.172 -0.031 -0.143 0.138 0.020

LB -1.105 -0.884 0.190 0.418 0.311 0.347 -0.036 0.291 0.502

LM 0.894 0.680 -0.377 1.033 0.515 0.148 1.120 -1.955 -0.213

LE -0.082 0.122 -0.111 0.203 0.392 0.035 0.421 1.018 0.665

Leu-Lys

HB HM HE SB SM SE LB LM LE

HB 6.443 -6.091 -0.492 0.568 -0.363 0.005 2.273 -1.165 -3.493

HM 3.380 2.638 0.027 0.210 -0.770 0.012 1.012 1.188 -2.843

HE 0.430 4.371 0.193 0.015 0.084 0.004 0.050 -0.065 0.382

SB 0.266 0.717 0.016 4.068 -2.389 -1.382 1.234 0.073 -1.159

SM 0.072 -0.185 -0.016 2.219 -0.425 -2.792 0.461 0.547 0.554

SE 0.006 0.012 0.004 0.348 0.487 -0.135 0.019 0.152 0.189

LB 1.255 -1.435 -0.086 0.904 -1.164 -0.286 1.996 -2.339 -1.383

LM 0.852 0.175 -2.680 1.132 -0.140 -0.706 1.846 1.090 -2.445

LE 0.232 -0.553 -0.469 0.276 0.445 -0.057 0.622 -1.360 0.409

Leu-glu

HB HM HE SB SM SE LB LM LE

HB 3.879 0.772 0.332 0.534 0.106 0.103 2.401 -0.508 0.785

HM 1.285 3.007 4.205 0.483 0.066 -0.008 0.842 1.816 0.608

HE 0.245 -1.200 -3.567 0.020 0.031 0.005 0.058 0.816 0.658

SB 0.376 -0.347 0.020 3.552 -3.461 -1.362 1.652 -0.376 -1.231

SM 0.071 0.003 0.163 2.067 1.190 0.090 0.487 0.420 1.003

SE 0.006 0.017 0.005 0.490 1.005 0.213 0.036 -0.351 0.034

LB -1.037 -0.596 0.294 0.313 0.302 0.033 1.960 0.523 -0.295

LM 0.922 -3.985 -0.377 1.073 0.893 0.246 2.156 1.250 0.461

LE -1.360 -0.706 -0.417 0.344 0.571 0.034 0.437 1.402 0.698

Trp-Trp

HB HM HE SB SM SE LB LM LE

HB 0.040 -0.691 -0.388 -0.765 0.008 0.000 -0.030 -0.259 0.016

HM 0.493 0.531 -0.033 0.010 0.001 0.144 -0.591 0.026

HE 0.051 0.001 0.003 0.000 0.004 0.017 0.008

SB -0.832 0.421 0.036 -0.395 -0.781 0.065

SM -0.040 0.126 -0.083 -0.246 0.026

SE 0.005 0.001 0.010 0.004

LB 0.159 0.097 0.030

LM 0.143 0.109

LE 0.021

Trp-Val

HB HM HE SB SM SE LB LM LE

HB -3.725 0.554 0.110 0.280 0.018 0.001 -0.406 0.039 0.042

HM -0.903 -0.363 0.465 -0.054 -0.166 0.004 -0.342 0.168 0.082

HE 0.315 -0.341 -0.191 0.005 -0.339 0.000 0.012 0.044 0.027

SB -0.252 0.030 0.004 -1.434 -0.257 0.119 -0.851 -0.177 -0.866

SM 0.018 -0.176 0.009 -2.271 -4.243 -0.166 -0.157 -0.566 -0.199

SE 0.001 0.003 0.000 -0.096 0.646 0.049 0.006 0.034 0.014

LB 0.045 -0.432 0.131 -0.431 0.085 0.006 -0.086 0.197 -0.221

LM -0.593 -0.419 0.042 -0.059 0.395 0.106 0.215 0.900 0.273

LE 0.047 0.084 0.029 0.529 0.083 0.014 0.151 0.103 0.266

Trp-Ile

HB HM HE SB SM SE LB LM LE

HB -0.488 0.034 0.048 -0.084 0.017 0.001 -1.141 -0.679 0.034

HM 0.311 -3.181 0.526 0.071 0.022 0.002 0.112 0.170 -0.009

HE 0.055 0.336 0.270 0.003 0.007 0.000 0.008 -0.088 0.024

SB 0.201 0.021 0.003 -2.527 -0.821 -0.103 -0.375 -0.060 0.049

SM 0.045 0.020 0.007 -2.813 -0.087 0.027 0.006 -0.245 0.431

SE 0.001 0.003 0.000 0.176 -0.008 0.031 0.003 0.022 0.009

LB 0.125 0.083 0.008 -0.240 -0.065 0.003 0.147 -0.353 0.059

LM 0.209 0.183 0.038 -0.534 -0.239 0.022 0.543 0.922 0.159

LE 0.043 0.111 0.026 0.180 0.056 0.009 0.306 0.181 0.117

Trp-Met

HB HM HE SB SM SE LB LM LE

HB -0.636 -0.928 0.023 0.019 0.005 0.000 -0.212 0.118 0.016

HM -1.051 -0.130 0.191 -0.079 0.008 0.001 0.052 0.167 0.112

HE 0.022 0.449 0.101 0.001 0.003 0.000 0.003 0.017 0.010

SB 0.045 0.011 0.001 -1.256 -1.220 -0.177 -0.322 0.017 0.006

SM 0.020 0.009 0.003 -0.870 0.089 0.045 -0.048 0.041 0.021

SE 0.000 0.001 0.000 0.035 -0.182 0.011 0.003 0.010 0.004

LB -0.045 0.031 0.003 0.106 -0.055 0.002 0.034 0.185 0.028

LM -0.077 -0.706 0.016 -0.037 0.120 0.010 0.197 0.377 0.078

LE 0.203 0.029 0.011 0.018 0.045 0.004 0.024 0.069 0.044

Trp-His

HB HM HE SB SM SE LB LM LE

HB 0.378 -0.361 0.275 0.028 0.008 0.001 0.183 -0.275 -0.089

HM 0.389 -0.160 -0.221 0.015 0.076 0.002 0.031 -0.027 0.041

HE 0.026 0.078 -0.230 0.001 0.002 0.000 0.005 -0.184 0.000

SB 0.025 0.007 0.001 -1.662 -0.169 0.041 -0.167 -0.516 0.027

SM -0.257 0.011 0.002 -0.017 -0.555 0.049 0.034 0.062 0.136

SE 0.000 0.001 0.000 0.042 0.164 0.012 0.002 0.008 0.004

LB -0.321 -0.879 0.005 0.335 0.287 0.002 0.276 -0.174 0.029

LM 0.033 0.131 0.019 -0.315 0.033 -0.102 0.143 0.305 0.127

LE 0.020 -0.036 0.012 0.027 0.024 0.004 0.072 0.123 0.054

Trp-Tyr

HB HM HE SB SM SE LB LM LE

HB -0.047 -0.982 0.394 0.284 -0.255 0.000 0.178 -0.518 0.034

HM 0.279 -4.350 0.466 0.021 0.020 0.001 -0.232 -0.366 -0.136

HE 0.081 0.386 0.139 0.002 0.004 0.000 0.029 -0.423 0.017

SB 0.044 -0.418 0.002 -1.787 0.021 -0.170 -0.044 -0.883 0.048

SM 0.010 -0.148 0.004 -0.676 -0.371 -0.683 0.086 0.382 0.051

SE 0.000 0.001 0.000 -0.140 0.195 0.029 0.003 0.023 0.009

LB 0.145 0.361 0.010 -0.388 -0.787 0.003 -0.929 0.123 -0.012

LM 0.287 0.038 0.029 -1.454 -0.231 0.020 -0.860 0.214 -0.169

LE 0.094 0.055 0.015 0.026 0.052 0.009 -0.018 0.153 0.077

Trp-Ala

HB HM HE SB SM SE LB LM LE

HB -2.611 -1.007 -0.622 -0.102 0.027 0.001 0.007 0.104 0.150

HM -2.285 0.369 0.394 0.081 0.030 0.003 -0.253 0.245 -0.124

HE 0.051 0.626 0.855 0.004 0.009 0.000 0.012 0.051 0.034

SB -0.960 0.033 0.005 -2.591 0.330 0.179 -0.181 0.203 0.069

SM -0.537 0.031 0.009 -0.456 -0.822 0.355 -0.273 -0.399 0.075

SE 0.001 0.004 0.000 0.262 0.274 -0.010 0.006 0.028 0.013

LB -2.022 -0.163 0.024 -0.142 0.087 0.006 -0.578 0.212 0.094

LM -0.135 0.123 0.238 -0.672 0.189 0.028 -0.445 -0.261 0.306

LE 0.061 0.112 0.036 0.204 0.116 0.013 0.234 0.797 -0.146

Trp-Gly

HB HM HE SB SM SE LB LM LE

HB -0.289 0.485 -0.042 -0.287 0.264 0.001 -0.355 -0.898 0.312

HM -0.055 0.508 0.625 -0.265 -0.015 0.006 -0.097 -0.740 -0.757

HE 0.091 -0.129 0.439 0.003 0.007 0.000 -0.470 -0.283 0.062

SB -0.670 -0.675 0.003 0.263 0.136 0.234 -0.330 0.047 -0.681

SM -0.314 0.059 0.008 -0.241 -0.914 0.234 -0.099 -2.042 0.246

SE 0.001 0.004 0.000 0.264 0.282 0.053 0.006 0.031 0.014

LB 0.011 -0.166 0.014 0.246 0.310 0.006 -1.912 -0.254 -0.344

LM -0.140 0.283 0.061 0.667 0.371 0.031 -0.422 0.354 0.379

LE 0.008 0.166 0.030 0.076 0.062 0.140 0.128 -0.133 0.258

Trp-Pro

HB HM HE SB SM SE LB LM LE

HB 0.744 -1.747 0.433 -0.138 0.014 0.000 0.222 0.105 0.033

HM 0.086 1.371 1.179 0.131 -0.183 0.002 -0.322 0.176 0.193

HE 0.042 0.238 0.292 0.004 0.006 0.000 0.047 0.053 -0.183

SB 0.047 0.023 0.003 0.833 -0.161 -0.479 -0.367 0.047 -1.815

SM 0.013 -0.219 0.006 0.222 -3.644 0.122 -0.026 -0.104 0.059

SE 0.001 0.002 0.000 -0.417 0.205 0.132 0.004 0.023 0.009

LB 0.288 -0.020 0.010 0.095 0.062 0.004 0.076 -0.155 -0.028

LM 0.465 -0.252 -0.167 0.200 0.133 0.023 0.886 -1.020 -0.230

LE 0.037 0.069 0.065 0.061 0.070 0.009 0.127 0.206 -0.706

Trp-Asn

HB HM HE SB SM SE LB LM LE

HB 0.286 0.044 0.245 0.064 -0.376 0.001 0.188 0.206 0.016

HM 0.886 -0.803 0.437 -0.286 0.026 0.002 -0.287 0.449 0.797

HE 0.278 0.501 0.919 0.003 0.010 0.000 0.010 0.081 0.024

SB 0.064 0.029 0.003 0.869 0.502 -0.275 -0.594 -0.477 0.076

SM 0.021 -3.425 0.010 0.808 -1.133 -0.626 0.076 -0.660 0.070

SE 0.001 0.002 0.000 0.092 0.449 0.051 0.005 -0.026 0.011

LB 0.145 -0.405 0.010 -0.455 0.166 0.005 0.522 -1.206 0.374

LM 0.210 -0.150 -0.828 -0.091 -0.575 -0.292 0.512 0.641 0.005

LE -0.263 -0.259 0.054 0.061 0.071 0.011 -0.573 0.138 0.030

Trp-Thr

HB HM HE SB SM SE LB LM LE

HB 0.009 -0.549 -0.130 -0.200 0.020 0.001 -0.521 -0.403 0.048

HM -0.631 0.305 -1.027 0.028 0.022 0.002 -0.001 -0.482 -0.019

HE 0.044 0.612 0.264 0.003 0.006 0.000 0.011 -1.121 0.029

SB -0.494 0.028 0.003 -0.510 -0.655 0.168 -0.132 -0.446 -0.268

SM -0.358 0.024 0.213 -0.106 -1.365 0.118 0.131 -0.072 -0.172

SE 0.001 0.002 0.000 0.213 -0.222 0.033 0.005 0.165 0.010

LB 0.031 0.056 0.136 0.247 0.134 0.005 -0.055 -0.052 0.224

LM 0.222 0.463 0.042 0.084 0.021 0.022 0.723 -0.092 0.224

LE 0.046 0.186 0.029 0.060 -0.041 0.011 -0.026 0.809 0.153

Trp-Ser

HB HM HE SB SM SE LB LM LE

HB -2.566 -0.068 -0.305 0.323 0.024 0.001 -0.738 -0.238 0.137

HM 0.318 -0.110 0.331 0.035 0.036 0.003 -0.049 0.109 -0.061

HE 0.152 0.809 0.955 0.004 0.011 0.000 0.012 0.042 0.034

SB -0.343 0.036 0.004 -0.569 -1.036 -0.133 -1.157 -0.310 -0.313

SM -0.040 -0.022 0.011 -0.738 -1.384 -0.292 -0.680 -0.046 0.111

SE 0.001 0.003 0.000 0.331 0.053 -0.499 0.007 0.036 0.015

LB 0.219 0.124 0.012 -0.087 0.097 0.137 -0.285 1.009 -0.289

LM 0.033 -0.028 0.081 -0.030 0.077 -0.035 0.242 0.637 -0.009

LE 0.209 -0.065 0.157 0.082 0.073 0.015 0.179 0.348 0.293

Trp-Arg

HB HM HE SB SM SE LB LM LE

HB 0.697 -0.288 -0.287 0.048 0.015 0.000 0.394 0.376 -0.172

HM 0.852 -1.007 -0.217 0.026 0.067 0.002 0.181 -0.510 0.095

HE 0.050 1.503 -0.189 0.002 0.007 0.000 0.009 0.156 0.026

SB 0.058 0.024 0.002 0.297 -1.029 -0.212 -0.179 -0.938 -0.374

SM 0.017 0.025 0.007 0.581 -0.314 -0.404 0.063 0.022 -0.013

SE 0.000 0.003 0.000 0.497 -0.189 0.059 0.004 0.028 0.011

LB 0.051 -0.400 -0.121 0.131 -0.041 0.004 0.337 -0.659 0.061

LM -0.119 -0.051 0.047 -0.275 -0.685 0.029 0.478 -0.245 -0.205

LE 0.035 0.069 -0.059 0.053 0.062 0.011 0.100 0.176 0.116

Trp-Gln

HB HM HE SB SM SE LB LM LE

HB 0.197 -0.910 -0.732 0.046 0.013 0.000 0.838 -0.697 -2.986

HM 0.715 0.984 -1.148 0.020 0.015 -0.202 0.068 0.255 0.292

HE -0.232 0.506 1.075 0.002 0.005 0.000 0.008 0.164 0.024

SB -0.078 0.092 0.002 0.388 0.222 -0.562 -0.311 0.126 0.212

SM 0.014 -0.253 0.046 -0.106 -1.935 0.286 0.347 -0.114 0.064

SE 0.000 0.002 0.000 0.062 0.178 0.023 0.003 0.015 0.007

LB 0.014 -0.010 -0.103 -0.245 0.059 0.003 -0.597 0.003 0.053

LM -0.375 -0.363 0.027 0.165 -0.101 0.015 0.382 0.230 0.019

LE 0.032 0.058 -0.232 0.041 0.582 0.007 -0.019 0.275 0.118

Trp-Asp

HB HM HE SB SM SE LB LM LE

HB 0.229 -0.189 0.059 0.074 0.020 0.001 0.578 -0.294 -0.480

HM -1.013 0.006 0.855 -0.016 0.029 0.003 0.117 -0.212 -0.057

HE 0.337 0.785 -0.031 0.003 0.009 0.000 0.010 0.130 0.026

SB -0.055 0.188 0.003 0.471 0.597 -0.371 0.066 0.545 0.063

SM 0.019 0.015 0.018 0.437 1.343 0.011 -0.237 -0.014 -0.733

SE 0.001 0.020 0.000 -0.078 0.514 0.079 0.005 0.253 0.013

LB -0.548 0.023 0.011 0.296 0.070 -0.066 -0.134 0.220 -0.010

LM 0.158 -0.005 0.043 0.014 0.153 0.046 -0.100 0.634 -0.038

LE -0.196 0.230 0.026 0.197 0.087 0.013 0.207 0.210 0.246

Trp-Lys

HB HM HE SB SM SE LB LM LE

HB 0.967 -0.130 0.266 0.052 -0.094 0.001 0.398 -0.003 0.148

HM 0.184 -0.581 1.361 0.026 -0.059 0.002 0.172 0.092 -0.147

HE 0.058 0.369 0.246 0.004 0.007 0.000 0.008 0.027 0.029

SB 0.141 0.026 0.066 0.488 -2.274 -0.710 0.532 -0.341 -0.427

SM 0.078 0.030 -0.122 0.496 -0.523 -0.609 0.028 0.029 0.016

SE 0.001 0.002 0.000 0.332 0.189 -0.295 0.004 0.284 0.011

LB 0.343 0.111 0.032 0.209 0.197 0.004 0.534 0.459 -0.128

LM 0.184 -0.261 0.042 0.195 -1.001 0.058 0.787 0.330 -0.003

LE 0.041 0.091 0.101 0.056 0.081 0.011 0.067 0.197 0.156

Trp-Glu

HB HM HE SB SM SE LB LM LE

HB 0.933 -0.277 -0.514 -0.177 0.016 0.002 0.394 -0.672 0.007

HM 0.824 1.195 -0.344 0.029 0.024 0.003 -0.053 -0.151 -0.830

HE 0.072 -0.452 -0.173 0.004 0.107 0.000 0.011 -0.106 0.039

SB 0.063 0.103 0.003 -0.585 -1.399 -0.281 -0.023 0.241 0.052

SM -0.119 0.021 0.007 1.318 -0.415 -0.982 0.109 0.550 -0.161

SE 0.001 0.004 0.000 -0.073 0.171 0.035 0.037 0.027 0.010

LB 0.178 0.111 0.030 0.194 -0.142 -0.126 0.707 0.188 0.041

LM 0.212 0.248 0.006 0.000 0.134 0.025 0.337 0.210 0.142

LE 0.053 -0.689 0.115 0.060 0.276 0.010 -0.269 0.254 0.293

Val-Val

HB HM HE SB SM SE LB LM LE

HB -2.252 -1.801 0.306 -1.405 -0.379 0.007 -0.251 0.148 0.265

HM -0.994 0.967 -1.077 -0.138 0.018 0.098 0.278 0.376

HE 0.943 0.062 0.033 0.002 0.048 0.361 0.168

SB -6.100 -3.026 0.140 -1.387 -2.185 -0.760

SM -2.056 -0.141 -1.174 1.029 -0.451

SE -1.304 0.032 0.105 0.048

LB -2.790 1.192 -0.036

LM -0.354 0.887

LE 0.257

Val-Ile

HB HM HE SB SM SE LB LM LE

HB -6.044 -1.535 0.518 0.887 0.192 0.005 0.581 0.358 0.331

HM 1.532 -0.699 -1.163 0.031 -0.276 0.012 -0.360 -1.482 0.049

HE -0.315 -0.583 -2.344 0.056 0.026 0.002 0.043 0.295 0.117

SB -0.087 -0.503 0.015 -7.743 -6.846 -1.011 -2.919 -1.116 -0.144

SM -0.026 0.138 0.135 -3.513 -2.784 -1.740 -0.512 -0.272 0.237

SE 0.006 0.013 0.002 -0.028 0.086 -0.032 0.114 -0.385 0.034

LB -0.684 0.026 0.132 -2.189 -0.113 0.015 -1.132 -0.743 -0.347

LM -0.378 1.027 0.167 -0.279 0.523 0.150 -0.550 1.490 0.713

LE 0.188 0.534 0.347 0.152 0.049 0.085 0.414 0.490 0.537

Val-Met

HB HM HE SB SM SE LB LM LE

HB -1.284 -1.443 0.092 0.236 0.021 0.002 -2.388 0.014 0.108

HM 0.245 -2.460 -0.420 0.031 0.031 0.004 0.002 0.220 0.481

HE -0.227 0.316 0.602 0.006 0.010 0.000 0.110 -0.061 0.049

SB -0.550 -0.602 0.006 -3.075 -1.812 0.457 -0.664 -1.284 0.138

SM 0.051 0.031 0.010 0.353 -1.292 0.233 0.247 0.194 -0.902

SE 0.002 0.004 0.000 0.272 0.226 0.133 0.009 0.033 0.015

LB -0.484 0.186 0.037 -1.127 0.232 -0.294 -1.142 -1.200 0.092

LM 0.216 0.527 0.058 -0.119 -0.956 0.032 -0.038 0.160 0.000

LE 0.257 0.153 0.046 -0.309 -0.046 0.015 0.092 0.235 0.153

Val-His

HB HM HE SB SM SE LB LM LE

HB 0.102 -0.551 -0.632 0.407 0.032 0.003 0.224 -1.136 -0.063

HM 1.785 -0.938 1.139 -0.164 0.042 0.007 0.241 -1.344 -1.679

HE 0.233 1.022 -0.420 0.006 0.012 0.001 0.017 0.079 0.067

SB -0.349 0.141 0.007 1.824 -2.924 -1.319 0.873 0.326 0.126

SM 0.025 -0.723 0.016 1.394 -3.968 -0.083 0.186 -0.620 0.047

SE 0.003 -0.468 0.001 0.258 0.414 0.127 0.033 0.027 0.129

LB -0.275 0.159 -0.183 -0.260 -0.005 0.010 0.349 -0.788 -0.176

LM -0.036 -0.553 0.172 0.473 0.135 0.027 0.455 -2.181 0.359

LE 0.089 0.020 0.202 0.088 -0.043 0.011 0.015 0.192 0.195

Val-Tyr

HB HM HE SB SM SE LB LM LE

HB -1.519 -3.615 0.112 0.486 -0.012 0.002 0.237 -1.170 0.224

HM 0.092 1.183 1.118 -0.041 0.050 0.006 -0.098 0.774 -0.682

HE 0.249 1.096 0.814 0.010 0.014 0.001 0.024 0.096 0.064

SB -1.358 0.107 -0.210 -1.899 -4.357 -1.920 -1.181 -1.068 -0.079

SM 0.051 -0.257 0.013 -1.703 -3.571 -3.081 -0.546 -0.954 0.250

SE 0.003 0.005 0.001 -0.125 -1.019 0.115 0.014 -0.009 0.033

LB 0.170 0.371 0.022 0.173 -0.202 0.015 -1.484 -1.865 0.202

LM 0.145 -0.351 0.140 -0.123 -0.413 0.062 0.464 0.870 -0.306

LE 0.089 0.158 0.117 0.141 0.319 0.033 0.200 0.533 0.276

Val-Ala

HB HM HE SB SM SE LB LM LE

HB -6.282 -1.445 1.251 -0.640 -0.113 0.007 -0.100 0.827 -0.011

HM -5.328 -0.061 0.645 0.080 0.110 0.016 -1.623 -0.768 -0.061

HE -0.001 0.121 2.640 0.020 0.030 0.001 0.009 0.231 0.220

SB -3.415 -0.542 0.019 -6.912 -1.628 -0.099 -2.568 -0.521 -0.361

SM -0.992 -1.177 0.161 -3.563 -0.382 0.424 -0.204 -0.155 -0.916

SE 0.005 0.016 0.001 -1.250 -2.308 -0.219 -0.030 0.093 0.049

LB -2.186 -0.042 -0.022 -1.692 0.233 -0.133 -1.587 0.225 -0.195

LM -1.009 -2.489 0.010 0.963 0.364 0.109 0.159 -0.550 0.397

LE 0.657 1.160 0.248 0.226 0.278 0.049 0.274 0.110 0.357

Val-Gly

HB HM HE SB SM SE LB LM LE

HB -1.028 5.130 -0.260 -0.462 0.083 0.004 0.126 -0.960 0.726

HM -1.696 -0.561 3.315 -0.254 0.208 0.018 0.507 -2.603 -0.024

HE -0.189 0.415 -0.378 0.016 -0.044 0.002 0.118 -0.034 0.269

SB -1.783 -0.350 -0.321 -1.086 0.266 1.057 -1.032 0.406 0.061

SM 0.092 0.002 0.023 -0.239 -2.142 1.133 -0.775 -1.826 0.323

SE 0.004 0.018 0.002 -0.379 -3.005 0.327 0.101 0.109 -0.811

LB -0.222 -0.385 0.048 -2.235 0.348 0.029 -4.195 0.190 -0.536

LM 0.779 1.107 0.186 -0.377 1.397 -0.040 0.058 0.650 0.370

LE 0.004 0.552 0.130 0.099 0.317 0.226 0.456 -0.041 0.520

Val-Pro

HB HM HE SB SM SE LB LM LE

HB 2.507 0.012 -0.459 0.196 -0.188 0.003 0.015 -0.108 0.240

HM 1.167 2.651 0.904 -0.266 -0.127 0.011 0.231 1.193 -0.088

HE 0.276 0.875 0.306 0.014 0.024 0.001 0.037 0.009 0.031

SB 0.140 -0.672 -0.669 3.007 3.343 -1.176 -0.563 -2.264 0.236

SM 0.049 -0.349 0.024 2.473 2.645 -0.110 -0.135 -0.989 0.451

SE 0.003 0.010 0.001 0.505 0.901 -0.700 -0.074 0.143 0.030

LB -0.495 -1.100 -0.036 0.509 0.218 0.021 1.044 -0.905 -0.047

LM 0.080 0.648 -0.229 0.928 0.569 0.070 1.090 0.556 -0.580

LE 0.557 0.156 0.235 0.194 0.570 0.034 0.153 -0.219 0.339

Val-asn

HB HM HE SB SM SE LB LM LE

HB 3.745 0.240 0.500 0.661 0.087 0.004 0.371 -0.802 -0.117

HM 2.363 0.241 -1.443 0.081 -0.039 0.010 0.781 0.928 0.162

HE 0.096 0.967 -1.884 0.019 0.025 0.001 0.036 0.149 0.157

SB -0.523 -0.148 0.019 3.013 0.599 -0.165 -0.148 -1.466 0.801

SM 0.014 -0.056 0.027 2.599 2.335 -0.113 -0.380 0.399 -0.506

SE 0.004 0.010 0.001 0.563 1.051 0.282 -0.157 0.083 -0.053

LB 0.394 -0.024 -0.285 -0.222 0.022 0.021 0.183 0.770 0.430

LM 0.544 -0.326 0.114 0.571 0.571 0.177 1.147 0.755 0.230

LE 0.176 -0.592 -0.254 0.209 -0.219 0.041 -0.096 1.038 0.021

Val-Thr

HB HM HE SB SM SE LB LM LE

HB -0.588 -0.713 0.277 0.164 0.099 0.004 0.105 -1.563 -0.839

HM 1.591 -0.676 -1.281 0.091 -0.527 0.012 0.526 -1.189 -0.535

HE 0.117 1.800 1.061 0.018 0.061 0.002 0.043 0.045 0.134

SB 0.324 -0.992 -0.019 -0.735 -3.316 -1.539 -1.169 -1.059 -0.340

SM 0.089 -0.036 0.024 0.561 -3.682 -1.893 0.660 -0.190 0.128

SE 0.005 0.014 0.002 -1.317 0.520 -0.972 0.024 -1.122 0.042

LB 0.419 0.483 0.134 -0.114 0.063 0.126 -1.031 -1.349 0.276

LM 0.368 0.581 0.189 -0.259 -0.134 -0.413 1.298 1.022 -0.986

LE -0.022 -0.811 -0.289 1.030 -0.065 0.017 0.354 0.524 0.211

Val-Ser

HB HM HE SB SM SE LB LM LE

HB -0.069 2.477 0.382 0.000 -0.133 -0.043 -0.308 1.391 -0.991

HM 1.779 -0.603 0.448 0.104 -0.368 0.015 0.432 -0.718 1.152

HE 0.106 0.365 0.135 0.023 0.036 0.001 0.047 0.203 0.253

SB -1.977 -0.083 -0.790 -0.681 -2.897 0.049 -0.158 -0.396 -0.668

SM 0.072 0.308 0.048 0.439 -2.204 0.170 0.541 -0.547 -0.035

SE 0.005 0.016 0.001 -0.354 -0.342 0.190 0.063 -1.352 0.014

LB -0.205 -0.378 -0.028 -0.053 -0.160 -0.089 -0.047 -1.162 0.290

LM 0.126 1.071 0.171 -0.775 0.223 0.215 -0.273 0.949 -0.724

LE -0.285 1.313 0.257 0.401 0.346 0.035 0.310 -0.500 0.379

Val-Arg

HB HM HE SB SM SE LB LM LE

HB 0.218 -1.094 -0.360 0.063 -0.186 0.143 0.755 -0.016 0.157

HM 0.924 -2.793 -3.551 0.083 -0.017 0.012 0.562 0.234 -0.489

HE 0.212 0.954 3.845 0.011 0.022 0.001 0.035 0.158 0.120

SB 0.038 -1.062 -0.537 2.001 -3.705 -4.674 0.899 -2.188 -1.118

SM 0.056 -1.237 -0.002 1.890 -7.193 -2.222 0.266 -0.420 -1.273

SE 0.003 0.012 0.001 -0.589 -0.445 -0.077 0.044 0.141 -0.797

LB 0.592 -2.595 -0.128 0.433 -0.134 -0.195 1.828 -1.089 -1.526

LM -0.227 0.447 0.249 0.408 0.151 -0.024 1.805 -0.764 0.644

LE 0.163 0.356 0.263 0.390 0.239 0.040 0.266 0.573 0.300

Val-Gln

HB HM HE SB SM SE LB LM LE

HB 1.053 -1.116 -0.295 -0.001 0.203 0.003 0.780 0.191 0.220

HM 1.567 -1.705 -0.871 0.066 0.053 -0.030 0.398 0.216 -2.587

HE 0.194 2.220 1.141 0.011 0.017 0.002 0.032 -0.021 -0.006

SB -0.241 -0.370 0.013 2.728 -4.942 -1.412 -0.287 -1.088 -0.819

SM 0.045 -0.201 0.159 1.498 -1.340 -1.407 0.509 -2.304 -0.746

SE 0.003 0.008 0.002 0.619 0.552 0.015 0.014 -0.530 -0.399

LB 0.134 -0.726 -0.041 -0.124 -0.950 -0.420 -0.164 -1.961 0.046

LM 0.225 0.186 0.045 0.834 0.556 0.052 0.111 0.034 0.626

LE 0.284 0.868 0.055 0.340 -0.048 0.027 0.126 0.429 0.336

Val-Asp

HB HM HE SB SM SE LB LM LE

HB 1.409 2.519 -0.184 -0.031 0.107 0.005 0.385 -0.038 0.538

HM 2.412 2.970 0.543 0.234 0.189 0.011 0.935 -0.262 0.566

HE 0.187 2.470 0.728 0.012 0.028 0.001 0.179 0.140 -1.487

SB -0.373 -0.943 -0.108 1.477 -0.340 0.292 0.141 -2.820 -0.832

SM 0.095 0.013 0.043 2.567 2.415 0.364 -0.034 -1.279 -0.406

SE 0.005 0.011 0.001 -0.355 -1.068 0.187 -0.535 -0.011 0.117

LB -0.371 -0.532 0.108 0.517 0.532 0.020 0.847 0.480 -0.311

LM 0.079 0.332 -1.251 0.934 0.466 0.099 1.716 -1.826 -1.543

LE 0.147 0.346 -0.123 0.135 0.101 0.041 0.139 0.125 0.416

Val-Lys

HB HM HE SB SM SE LB LM LE

HB 3.657 -0.918 -2.330 0.341 -0.038 -0.185 0.752 0.466 -0.448

HM 1.673 0.378 -0.863 -0.142 0.682 0.112 0.949 0.184 0.281

HE 0.266 2.219 -0.652 0.015 0.110 0.002 0.034 0.120 0.039

SB 0.024 -0.389 -0.556 3.790 -2.573 -4.266 1.429 0.078 -0.554

SM 0.116 0.176 0.035 2.007 -3.889 -3.401 0.513 0.610 -2.985

SE 0.004 0.014 0.002 0.502 0.280 -1.528 0.017 0.196 0.026

LB 1.037 -0.911 1.107 0.037 -0.492 0.005 1.804 -3.069 -0.513

LM 0.581 0.932 -0.287 1.110 -0.958 0.188 1.646 1.036 -0.601

LE 0.145 0.525 0.117 0.196 0.016 -0.059 0.453 0.366 -0.022

Val-Glu

HB HM HE SB SM SE LB LM LE

HB 1.129 2.330 -0.210 0.255 -0.162 0.005 1.420 0.684 -0.326

HM 2.478 1.108 -4.174 0.436 -0.062 -0.012 0.549 1.552 -1.475

HE 0.313 2.534 1.943 0.019 0.136 0.002 0.039 0.284 0.165

SB -0.376 -0.222 0.137 1.050 -3.740 -2.467 1.709 -1.322 -1.154

SM 0.060 -0.178 0.026 2.773 -0.911 -0.691 0.535 -0.784 -0.255

SE 0.005 -0.241 0.002 0.430 0.299 -0.240 0.124 0.108 0.036

LB 0.263 -0.040 0.013 -0.224 0.391 0.058 0.926 -1.853 -0.102

LM 0.561 0.366 0.334 0.712 -0.198 0.088 1.732 0.527 -0.763

LE 0.456 0.625 0.135 0.240 -0.273 0.036 0.201 1.310 0.706

Ile-Ile

HB HM HE SB SM SE LB LM LE

HB -1.500 0.827 -0.779 -0.177 -0.237 0.004 0.420 -0.771 0.536

HM -0.550 -3.222 -0.127 -0.087 0.010 -0.131 0.665 0.522

HE 1.075 0.011 0.017 0.002 0.064 0.177 0.129

SB -5.107 -1.851 -0.221 -0.907 0.587 0.171

SM -0.710 0.473 0.235 0.549 0.175

SE 0.043 0.010 0.049 0.021

LB -0.904 0.708 0.211

LM 0.479 0.533

LE 0.144

Ile-Met

HB HM HE SB SM SE LB LM LE

HB -0.677 -1.623 0.176 -0.036 -0.067 0.001 -0.114 0.095 -0.026

HM -1.772 -3.427 -0.280 0.021 0.023 0.003 0.295 0.513 0.080

HE -0.476 -0.543 0.533 0.003 0.008 0.000 0.009 0.052 0.148

SB -0.029 0.026 0.003 -3.836 -1.025 -0.536 -0.344 -0.486 -0.257

SM -0.152 0.205 0.007 0.447 -1.340 0.705 0.387 -0.437 -0.060

SE 0.003 0.003 0.000 0.052 0.148 0.034 0.005 0.023 0.010

LB -0.469 -0.226 0.011 -0.432 -0.024 0.546 -0.126 0.262 -0.644

LM 0.185 -0.134 0.028 0.191 0.248 0.024 -0.321 -0.991 0.308

LE 0.175 0.115 -0.034 -0.036 0.042 0.010 0.073 -0.365 0.134

Ile-His

HB HM HE SB SM SE LB LM LE

HB -0.841 -0.917 -0.424 0.072 0.003 0.001 0.386 -0.599 0.184

HM 1.380 -1.048 0.438 0.033 0.020 0.006 0.321 0.249 0.182

HE -1.018 0.847 1.174 0.005 0.009 0.001 0.013 0.175 0.021

SB -0.172 -0.143 0.005 -1.936 -2.509 -0.301 0.479 -0.516 -0.278

SM 0.039 0.148 0.009 0.416 -0.608 -0.968 0.259 0.172 0.097

SE 0.001 0.006 0.001 0.058 0.405 0.030 0.022 0.020 0.007

LB 0.093 -0.346 0.013 0.375 0.259 0.005 0.328 0.743 0.204

LM 1.127 -0.605 0.139 0.182 0.350 0.017 0.228 -0.593 0.062

LE -0.038 0.176 -0.220 0.131 0.040 0.007 -0.003 0.148 -0.159

Ile-Tyr

HB HM HE SB SM SE LB LM LE

HB -3.487 -3.743 0.272 -0.370 -0.013 0.002 -0.138 -1.593 -0.280

HM -0.043 -0.389 0.356 0.049 0.286 0.005 0.056 0.453 0.354

HE 0.312 1.750 0.640 0.006 0.120 0.001 0.020 0.083 0.196

SB 0.133 -0.863 0.006 -4.331 -7.121 -2.336 -1.324 -0.635 -0.191

SM 0.045 -0.425 0.009 -1.566 -2.217 -2.802 0.427 -0.449 0.228

SE 0.002 0.004 0.001 -0.774 0.274 0.077 0.008 0.044 0.155

LB 0.430 -0.341 0.019 -0.313 0.088 0.008 -0.727 -1.106 -0.637

LM 0.572 0.169 0.082 0.315 -0.364 0.043 0.938 1.206 -0.310

LE -0.796 0.094 0.062 -0.129 -0.017 0.023 0.110 0.672 0.201

Ile-Ala

HB HM HE SB SM SE LB LM LE

HB -8.970 0.096 1.136 0.125 -0.180 0.005 0.106 -0.630 -0.095

HM -5.938 -0.459 -0.347 0.365 0.132 0.011 0.399 0.908 -0.102

HE -1.091 1.945 2.927 0.048 0.020 0.001 -0.003 0.511 -0.330

SB -0.428 -0.127 0.013 -3.852 -0.756 0.267 -0.954 0.208 0.126

SM -1.540 -0.585 0.033 -1.626 0.117 0.107 -0.892 0.462 0.681

SE -0.140 0.013 0.001 -0.224 0.335 0.138 0.016 -0.042 0.032

LB -5.840 -1.412 -0.028 -0.401 0.460 0.016 -1.355 -0.198 0.348

LM -2.163 -2.010 0.162 -0.922 0.566 0.062 -0.275 -0.316 0.299

LE 1.127 -0.528 0.343 0.249 0.289 -0.218 0.369 0.283 0.247

Ile-gly

HB HM HE SB SM SE LB LM LE

HB 3.001 3.721 1.259 -0.197 0.008 0.006 -0.668 -1.961 0.288

HM -3.145 0.266 1.364 -0.058 0.073 0.014 -0.278 -0.560 -0.314

HE 0.195 0.232 0.774 0.009 0.017 0.002 0.032 0.193 -0.732

SB -0.916 0.190 0.010 -1.634 1.172 1.134 0.427 -1.032 -0.627

SM -0.432 -0.866 0.015 1.450 2.256 0.909 -1.451 -0.117 -0.274

SE 0.003 0.013 0.002 -0.804 -0.340 0.212 0.015 -0.198 -0.129

LB 0.139 0.170 -0.030 0.035 0.531 0.126 -0.052 0.617 -0.355

LM 0.904 0.110 -0.264 0.713 0.408 0.070 -0.304 1.395 1.313

LE 0.839 0.072 0.116 0.190 0.479 0.036 -0.453 0.113 0.532

Ile-Pro

HB HM HE SB SM SE LB LM LE

HB 2.571 0.152 -0.163 0.105 0.031 0.003 0.561 -2.908 -0.174

HM 1.472 2.096 -0.623 0.177 0.052 0.008 0.257 0.284 0.318

HE 0.180 0.323 0.858 0.011 -1.522 0.001 0.024 0.189 0.106

SB 0.105 -1.068 -0.102 2.099 1.272 -0.272 -0.274 -3.253 -0.785

SM 0.145 0.052 0.017 1.921 1.115 1.003 0.012 -0.108 -0.411

SE 0.005 0.008 0.001 0.220 0.207 -0.166 0.053 0.051 0.120

LB -0.002 0.406 -0.681 0.760 0.196 -0.023 1.259 -1.052 -0.122

LM 0.321 -0.186 0.109 0.192 0.445 0.050 0.758 0.459 0.547

LE 0.104 0.356 0.077 0.127 0.140 0.023 0.334 0.582 0.269

Ile-asn

HB HM HE SB SM SE LB LM LE

HB 1.117 0.345 -2.536 0.151 0.263 0.003 -0.555 -0.219 0.189

HM 0.368 -0.966 0.857 0.075 -0.021 0.008 0.435 1.160 -0.963

HE 0.123 1.534 1.012 0.012 0.018 0.001 0.027 0.110 -0.299

SB 0.478 -0.262 0.010 3.133 -0.536 0.393 -0.553 -2.246 -0.644

SM -0.014 -0.352 0.019 1.699 0.166 -0.707 0.380 -0.114 -0.399

SE 0.003 0.008 0.001 0.561 -0.632 0.087 0.012 0.087 0.029

LB -0.448 -0.150 -0.514 -0.181 0.056 0.011 0.186 -0.063 0.448

LM 0.730 -0.047 -0.226 0.398 -0.101 0.258 0.476 0.642 0.713

LE 0.071 0.698 0.184 0.369 0.412 0.029 0.062 0.750 0.729

Ile-Thr

HB HM HE SB SM SE LB LM LE

HB -3.981 -0.633 -0.043 0.335 0.195 0.003 0.818 -0.136 0.548

HM -2.495 -0.587 -0.506 0.211 0.066 0.009 0.365 0.411 -0.256

HE 0.396 2.704 0.255 0.099 0.050 0.002 0.029 0.254 0.627

SB -0.377 0.367 0.012 -0.560 -2.130 -1.258 -0.609 -2.640 0.086

SM 0.047 0.133 0.016 -0.237 -1.519 -0.442 -0.047 0.420 0.376

SE 0.003 0.010 0.002 0.484 0.179 -0.556 -0.057 0.078 0.028

LB 0.002 -1.399 0.053 0.047 -0.282 0.052 0.752 -1.745 -0.646

LM 0.786 0.678 0.142 0.058 0.370 -0.015 0.748 1.891 0.074

LE 0.075 0.545 0.369 -0.524 0.380 0.028 0.292 -0.488 0.205

Ile-Ser

HB HM HE SB SM SE LB LM LE

HB 0.475 1.418 0.447 -1.095 -0.391 -0.248 -0.180 -1.340 -0.236

HM -1.380 0.662 2.774 0.160 0.272 0.011 -0.216 1.618 0.605

HE 0.364 1.495 1.182 0.017 0.026 0.001 0.093 -0.448 0.378

SB -0.593 -0.118 0.024 -1.636 0.233 -0.640 -1.155 -0.774 -0.201

SM 0.060 0.187 0.025 1.137 -0.708 -0.959 0.182 -0.271 -0.383

SE -0.087 0.012 0.001 -0.354 -0.264 0.279 0.017 -0.090 0.070

LB 0.019 -4.174 0.035 0.452 -0.184 0.020 -0.234 -4.447 -1.631

LM -1.101 -0.299 0.222 -0.025 0.590 0.075 -0.479 1.986 0.797

LE 0.160 0.311 0.537 0.276 0.530 0.034 -0.195 1.532 0.553

Ile-Arg

HB HM HE SB SM SE LB LM LE

HB 3.300 -4.621 -0.126 0.243 -0.363 -0.002 0.707 0.259 0.283

HM 0.794 1.074 -3.477 0.062 -0.105 0.009 0.306 -0.426 0.410

HE 0.410 2.364 -2.719 0.008 0.035 0.001 0.133 0.162 0.151

SB 0.229 -0.737 -0.138 0.582 -1.886 -1.989 0.504 -2.107 -0.615

SM 0.177 -0.019 -0.124 1.342 0.002 -1.618 0.521 0.100 -1.281

SE 0.003 0.009 0.001 0.329 -0.048 -0.363 0.012 0.118 0.484

LB -0.542 -1.577 0.116 0.603 -0.138 -0.131 1.315 -0.979 -0.051

LM 0.533 -0.250 0.297 0.439 0.267 -0.244 1.780 1.922 0.153

LE 0.215 1.273 1.784 -0.089 0.362 0.026 0.270 0.758 0.152

Ile-Gln

HB HM HE SB SM SE LB LM LE

HB -0.254 1.691 -1.275 0.311 0.151 0.003 0.304 0.473 -0.074

HM 1.071 0.797 -0.465 0.070 0.039 0.006 0.432 0.415 0.287

HE -0.880 -0.568 -2.445 0.008 0.011 0.002 0.022 0.094 0.123

SB 0.098 -0.401 0.007 1.112 -1.806 -0.801 0.993 -0.606 -0.372

SM 0.073 0.420 0.012 -1.529 1.045 0.690 0.678 0.179 0.049

SE 0.003 0.006 0.002 0.227 -0.397 0.135 0.008 0.105 0.020

LB -1.041 -0.519 0.236 0.423 -0.767 0.054 1.506 0.526 -0.667

LM 0.466 -0.966 0.087 0.588 0.200 0.035 0.471 1.560 -1.220

LE 0.100 1.070 0.483 0.234 0.114 0.020 0.282 0.389 0.173

Ile-Asp

HB HM HE SB SM SE LB LM LE

HB 2.773 2.375 0.801 0.275 0.052 0.003 0.801 -1.230 -1.450

HM 1.087 -0.054 3.002 0.103 0.063 0.008 0.589 0.868 -1.305

HE 0.308 1.757 2.380 0.010 0.019 0.001 0.053 -0.271 0.144

SB -0.754 -0.147 0.009 2.859 -0.404 0.377 0.244 -1.403 -0.130

SM -0.345 -0.556 0.019 1.453 0.345 0.995 0.517 0.571 0.085

SE 0.003 0.009 0.001 0.813 0.705 0.105 0.014 0.318 0.012

LB -1.023 0.192 0.027 0.633 -0.663 0.013 0.727 -3.111 -0.629

LM 0.364 0.683 -0.052 1.243 -0.151 -1.011 1.168 1.170 0.616

LE 0.132 0.304 -0.091 0.214 0.248 0.027 -0.214 1.010 0.296

Ile-Lys

HB HM HE SB SM SE LB LM LE

HB 3.536 -3.016 -0.130 0.262 -0.018 -0.119 0.989 1.321 -1.713

HM 1.159 -0.754 0.364 0.080 0.331 0.011 0.499 -0.029 0.099

HE 0.773 2.512 3.089 0.010 0.020 0.002 0.028 0.563 0.158

SB 0.512 0.103 0.192 3.306 -1.796 -3.001 1.468 0.103 -3.625

SM 0.047 0.045 0.020 2.349 -1.635 -1.948 0.330 -1.023 -0.102

SE 0.005 0.010 0.002 0.356 0.118 -1.562 0.011 -0.099 -0.048

LB 0.470 -0.070 -0.319 0.398 -0.265 0.014 1.577 -4.018 -1.138

LM 0.555 0.016 -0.214 0.663 0.800 0.108 1.336 1.177 0.996

LE 0.183 0.980 0.086 0.415 0.218 0.028 0.471 0.862 0.167

Ile-Glu

HB HM HE SB SM SE LB LM LE

HB 0.659 1.552 1.218 0.041 0.005 0.023 0.770 0.349 0.260

HM -0.897 -0.832 0.532 0.179 -0.410 0.010 0.549 1.019 0.741

HE -0.046 2.218 -0.233 0.011 0.133 0.002 0.029 0.333 -0.713

SB 0.268 -1.420 -0.084 1.149 -4.530 -1.075 0.627 -0.251 -1.153

SM 0.492 -0.078 -0.204 1.760 0.196 -1.830 0.278 -0.381 -1.503

SE 0.004 -0.120 0.002 0.189 0.438 0.103 0.022 0.073 -0.121

LB -0.351 -0.060 -0.643 0.738 -0.210 -0.008 1.825 -0.998 0.553

LM -0.411 0.129 0.388 0.577 0.300 0.056 1.975 2.447 1.229

LE 0.511 1.307 0.394 0.173 0.187 0.024 0.270 0.792 0.383

Met-met

HB HM HE SB SM SE LB LM LE

HB -0.981 0.591 0.044 -0.073 0.008 0.001 0.035 -0.120 0.025

HM -1.529 -0.287 0.539 0.008 0.001 -0.457 -0.179 -0.873

HE 0.144 0.001 0.003 0.000 0.003 0.029 0.021

SB 0.119 -1.469 0.028 -0.064 -0.760 0.094

SM -0.007 -0.341 0.065 0.079 0.121

SE 0.006 0.003 0.009 0.004

LB 0.089 0.333 0.027

LM 0.060 0.164

LE 0.022

Met-his

HB HM HE SB SM SE LB LM LE

HB -0.794 -0.805 -0.001 0.034 0.043 0.001 0.235 -0.311 0.027

HM 0.499 -0.888 -0.215 0.106 0.012 0.001 0.066 0.115 0.088

HE 0.196 0.129 0.274 0.002 0.004 0.000 0.006 0.032 0.027

SB 0.114 -0.361 0.002 -0.417 0.141 -0.575 0.002 0.424 0.020

SM 0.008 0.011 0.004 0.117 -0.204 0.039 0.028 0.245 -0.083

SE 0.001 0.001 0.000 0.054 0.561 0.067 0.003 0.030 0.003

LB 0.058 -0.369 0.005 -0.195 -0.026 0.035 0.029 -0.718 -0.040

LM -0.036 -0.430 0.056 -0.165 -0.450 0.136 0.296 0.213 -0.027

LE 0.026 -0.232 0.026 0.020 -0.320 0.003 -0.019 -1.294 0.196

Met-tyr

HB HM HE SB SM SE LB LM LE

HB -0.676 -2.639 0.307 -0.161 -0.177 0.001 -0.050 -0.359 0.197

HM -0.970 -1.754 0.449 0.020 0.064 0.001 -0.126 0.373 0.096

HE 0.050 1.208 0.556 0.004 0.004 0.000 0.007 -0.301 0.025

SB -0.002 0.019 0.002 -0.208 -0.883 0.150 -0.128 0.177 0.038

SM 0.011 0.017 -0.517 0.121 -0.726 0.213 0.240 0.283 0.049

SE 0.001 0.002 0.000 0.062 0.432 0.030 0.004 -0.016 0.011

LB 0.212 -1.356 0.006 -0.271 0.017 0.004 0.626 -1.126 0.060

LM -0.032 0.210 0.036 -0.172 0.148 0.018 -0.075 0.111 -0.281

LE 0.035 0.130 0.025 0.038 -0.061 0.010 0.089 0.432 -1.892

Met-ala

HB HM HE SB SM SE LB LM LE

HB -3.199 0.345 0.480 -0.568 0.326 0.002 0.025 -0.489 0.103

HM -2.259 -2.939 2.354 0.033 0.030 0.004 -0.654 -0.356 0.172

HE 0.156 1.309 0.863 0.004 0.009 0.000 0.014 -0.311 0.066

SB -0.919 0.156 0.004 -0.946 -0.549 -0.112 0.033 0.242 0.077

SM -0.065 -0.726 0.009 0.957 1.430 -0.012 0.093 -1.774 -0.131

SE 0.039 0.004 0.000 0.205 0.297 0.039 -0.123 0.027 0.014

LB -0.240 0.150 0.014 0.388 0.100 0.008 0.596 -0.244 0.050

LM -1.680 -0.086 0.072 -0.669 0.138 0.026 0.255 -0.047 0.433

LE 0.259 0.198 -0.579 -0.011 0.120 0.045 -0.119 0.095 0.202

Met-gly

HB HM HE SB SM SE LB LM LE

HB -1.313 -0.012 0.093 -0.180 0.045 0.003 -0.099 -0.142 0.355

HM 1.140 0.706 0.022 -0.008 -0.117 0.005 -0.196 -0.082 0.411

HE -0.101 -1.173 0.090 0.004 0.007 0.000 0.112 0.279 -0.188

SB 0.133 0.031 0.003 -0.629 0.787 0.137 -0.231 -0.630 0.086

SM 0.002 -0.315 -0.071 0.378 1.141 0.145 0.095 -0.210 -0.560

SE 0.001 0.004 0.000 0.465 0.305 0.053 0.007 0.139 0.557

LB -0.130 -0.052 0.012 0.295 0.268 0.031 -1.410 0.986 -0.510

LM -0.032 0.374 0.066 0.315 0.169 0.051 -0.033 1.353 0.119

LE 0.059 0.226 0.064 0.455 -0.075 0.015 -0.156 0.305 0.132

Met-pro

HB HM HE SB SM SE LB LM LE

HB 0.949 0.518 0.223 -0.422 0.380 0.001 -0.340 -1.273 0.061

HM 1.000 0.477 0.002 0.022 0.020 0.002 0.000 -0.284 -0.326

HE 0.067 0.816 0.339 0.003 0.007 0.000 0.009 0.306 0.033

SB 0.010 0.185 0.005 1.273 -0.486 0.239 -0.011 -0.643 0.080

SM 0.015 0.021 -0.005 0.353 0.578 -0.156 0.053 -0.710 0.073

SE 0.001 0.003 0.000 0.094 0.134 0.034 0.006 0.018 0.010

LB -0.338 0.219 -0.156 0.324 0.056 0.006 0.095 0.277 -0.628

LM 0.180 0.293 0.050 0.248 -0.030 0.022 -0.010 0.572 -0.197

LE 0.044 -0.098 0.150 0.260 0.059 0.010 -0.015 0.280 0.053

Met-asn

HB HM HE SB SM SE LB LM LE

HB 0.357 -0.822 0.159 -0.118 -0.150 0.001 0.454 -0.220 -0.469

HM 0.167 0.287 0.702 0.025 0.106 0.004 0.129 -0.714 -0.249

HE 0.066 0.394 0.398 0.005 0.008 0.000 0.009 -0.063 0.031

SB 0.065 0.131 0.005 0.068 0.258 -0.218 -0.237 0.301 0.441

SM 0.019 0.157 0.008 0.408 0.241 0.399 0.061 -0.338 0.089

SE 0.002 0.002 0.000 0.516 0.291 0.037 0.006 0.037 0.011

LB -0.011 -0.174 0.061 0.530 0.099 0.006 0.708 0.425 0.054

LM -0.142 -0.256 0.047 0.171 -0.001 -0.074 -0.548 1.097 -0.756

LE 0.046 0.125 -0.500 0.049 0.380 0.013 0.074 0.658 0.105

Met-thr

HB HM HE SB SM SE LB LM LE

HB -1.147 3.307 0.132 0.303 0.019 0.001 0.105 -0.170 -0.082

HM 0.689 0.847 -3.636 0.119 0.024 -0.039 0.023 -0.022 0.128

HE 0.083 0.730 0.525 0.004 0.053 0.000 0.045 -0.001 0.047

SB 0.257 0.137 0.004 -1.662 0.881 0.574 -0.401 0.276 -0.081

SM 0.017 0.101 0.007 -0.112 -1.560 -0.692 0.096 -0.245 0.063

SE 0.001 0.003 0.000 0.188 -0.208 0.035 0.006 0.143 0.011

LB 0.264 0.318 0.009 0.112 0.382 0.006 -0.401 -0.406 0.698

LM -0.151 0.098 0.055 0.326 -0.741 -0.035 -0.574 -0.001 0.013

LE 0.091 0.162 0.048 0.140 -0.001 0.012 0.083 0.132 0.253

Met-ser

HB HM HE SB SM SE LB LM LE

HB -0.746 -0.326 -0.254 0.282 0.048 0.001 -0.383 0.284 0.143

HM 1.168 -2.378 1.880 0.031 -0.074 0.003 -0.226 -1.040 -0.098

HE 0.107 0.355 -0.417 0.006 0.011 0.000 0.013 -0.165 0.163

SB -0.037 0.172 0.005 -0.991 -0.437 -0.313 -0.088 0.261 0.063

SM 0.020 0.032 0.011 1.003 -1.259 0.491 -0.008 0.121 -0.152

SE 0.001 0.020 0.000 0.729 0.423 0.159 0.008 0.032 0.015

LB -0.983 -0.350 -0.057 0.083 0.085 0.008 0.242 -0.076 -0.188

LM -1.878 0.143 0.395 -0.755 -0.128 0.032 0.186 0.121 0.831

LE -0.225 0.571 0.065 -0.597 -0.219 0.015 -0.070 0.496 0.457

Met-arg

HB HM HE SB SM SE LB LM LE

HB 0.981 -1.532 -0.327 0.155 0.017 0.001 0.253 -0.680 -0.519

HM -0.385 -2.010 0.578 0.026 0.024 0.003 0.139 0.134 0.088

HE 0.182 0.098 0.395 0.003 0.007 0.000 0.009 0.149 0.051

SB -0.258 0.030 0.002 0.828 -0.863 0.013 -0.104 0.471 0.168

SM 0.019 0.003 0.008 0.452 -0.466 -0.237 0.101 -0.155 0.076

SE 0.001 0.003 0.000 0.141 0.437 0.040 0.005 0.026 0.046

LB 0.037 0.644 -0.195 0.294 -0.006 0.005 0.654 -0.586 -0.346

LM 0.248 0.438 0.012 -0.110 -0.147 0.050 0.410 0.205 0.403

LE 0.054 0.176 0.121 0.142 -0.777 0.012 0.338 0.114 -0.506

Met-gln

HB HM HE SB SM SE LB LM LE

HB 0.192 0.890 -0.424 -0.074 0.015 0.001 0.355 0.689 -0.281

HM 0.782 -0.238 0.114 0.251 -0.182 0.005 0.274 0.220 0.358

HE 0.166 0.437 -0.011 0.003 0.005 0.000 0.008 0.005 0.220

SB 0.046 0.186 0.003 -0.599 -0.598 -0.378 -0.189 0.461 0.031

SM 0.014 0.123 0.005 0.619 -0.764 -0.618 0.101 0.143 -0.290

SE 0.001 0.002 0.000 -0.327 -0.096 0.024 0.004 0.015 0.009

LB 0.046 0.033 -0.983 0.151 0.043 0.004 0.432 -0.595 0.159

LM 0.259 0.102 0.044 0.108 -0.038 0.048 0.104 0.312 0.262

LE -0.278 -0.277 0.044 0.032 0.110 0.009 0.117 0.028 -0.440

Met-asp

HB HM HE SB SM SE LB LM LE

HB 0.074 0.617 -0.233 0.079 0.019 0.001 1.058 -0.804 -0.193

HM 1.254 0.470 0.681 0.030 0.131 0.003 0.157 -0.389 0.396

HE 0.098 0.971 0.599 0.003 0.010 0.000 0.012 0.092 -0.020

SB 0.049 0.029 0.004 1.084 -0.587 -0.062 -0.789 -0.408 0.429

SM -0.039 0.030 0.010 0.170 0.378 0.277 0.102 -0.744 -0.128

SE 0.002 0.003 0.000 0.080 -0.133 -0.161 0.006 0.031 0.013

LB 0.005 -1.125 0.011 0.433 0.108 0.006 0.827 -0.609 0.027

LM -0.014 0.706 0.053 0.915 0.012 0.029 0.451 0.736 -0.593

LE 0.056 0.077 0.055 0.048 -0.409 0.013 0.221 -1.773 -1.464

Met-lys

HB HM HE SB SM SE LB LM LE

HB 0.448 -1.493 -0.038 0.068 0.019 0.001 0.562 -0.301 0.014

HM 1.475 -0.574 -1.684 0.028 -0.041 -0.025 0.274 0.565 -0.737

HE 0.091 0.251 0.916 0.004 0.009 0.000 0.047 0.110 0.192

SB 0.004 0.028 0.128 1.219 0.180 -0.358 0.122 -0.318 -1.046

SM 0.021 -0.046 0.175 0.763 -1.632 -0.913 0.204 0.231 -0.137

SE 0.001 0.002 0.000 0.090 0.354 -0.159 0.005 0.032 0.014

LB -0.038 -0.800 -0.838 0.567 -0.068 0.005 0.258 0.675 0.085

LM 0.252 0.859 0.074 0.208 -0.300 -0.232 0.521 0.543 -0.289

LE 0.055 -1.523 0.102 -0.005 0.124 -0.371 0.094 0.185 0.171

Met-glu

HB HM HE SB SM SE LB LM LE

HB 1.176 0.569 0.066 0.075 0.019 0.001 0.580 0.156 -0.174

HM 1.283 0.112 0.290 0.031 0.010 0.003 0.135 0.167 -1.327

HE 0.099 1.143 1.078 0.005 0.009 0.000 0.010 0.299 -0.270

SB 0.073 -0.110 0.004 -0.374 -1.199 -0.061 0.178 0.002 -0.056

SM 0.081 -0.078 0.008 0.153 0.254 -0.159 0.212 -0.318 -0.094

SE 0.001 -0.126 0.000 0.094 -0.102 0.038 0.007 0.022 0.010

LB -0.564 0.123 0.013 0.130 -0.176 0.115 0.113 0.229 0.475

LM 0.047 -0.762 0.229 0.472 -0.015 0.022 0.411 0.402 -0.106

LE 0.066 -1.113 -0.180 0.052 -0.084 0.009 0.211 -0.059 -0.166

His-His

HB HM HE SB SM SE LB LM LE

HB 1.073 0.694 0.057 0.049 -0.471 0.002 0.122 -0.355 0.122

HM -1.774 1.091 0.128 0.029 0.003 0.129 -0.911 -0.343

HE -0.001 0.003 0.008 0.000 0.075 0.126 0.061

SB 0.371 0.732 0.062 -0.042 0.293 0.170

SM -0.012 -0.335 -0.002 -0.477 -0.164

SE 0.011 0.004 0.012 0.006

LB -0.364 0.202 0.108

LM 0.099 0.084

LE 0.112

His-Tyr

HB HM HE SB SM SE LB LM LE

HB 0.437 0.180 0.087 -0.012 -0.054 0.001 0.201 0.088 0.053

HM -0.818 -0.578 -0.664 0.465 -0.028 0.002 -0.152 0.220 0.275

HE 0.150 -1.084 0.529 0.003 0.005 0.000 0.011 0.048 0.048

SB -0.150 -0.345 0.002 0.965 -0.080 0.094 0.050 -0.277 0.096

SM 0.013 0.097 0.005 -1.251 -2.098 0.227 0.064 0.443 0.057

SE 0.001 0.002 0.000 0.066 0.192 0.024 0.004 0.014 0.007

LB 0.359 0.174 0.010 0.521 -0.092 0.004 0.230 0.533 0.074

LM -0.209 0.212 0.044 0.025 -0.127 0.014 0.044 -0.855 -0.049

LE 0.181 -0.469 0.082 0.386 -0.171 0.006 0.204 0.052 0.101

His-ala

HB HM HE SB SM SE LB LM LE

HB 2.504 1.565 0.220 -0.533 0.067 0.003 0.506 -0.942 0.063

HM 1.651 -3.720 -0.001 0.022 0.075 0.106 0.021 -1.239 -0.345

HE 0.164 -3.792 0.104 0.005 0.003 0.000 -0.156 0.115 0.044

SB -0.003 -0.021 0.005 -0.274 1.168 0.241 -0.093 -0.091 -0.258

SM 0.023 0.600 0.013 -3.220 0.687 0.072 -0.861 0.156 -0.108

SE -0.144 -0.277 0.000 -0.499 0.513 0.052 0.009 -0.025 0.011

LB 0.361 0.488 0.069 0.041 -0.156 0.009 -0.054 0.701 0.162

LM -0.294 -0.548 0.117 0.290 0.546 0.022 -0.478 -0.831 0.304

LE -0.310 0.047 0.101 0.100 0.099 -0.002 -0.161 0.016 -0.345

His-Gly

HB HM HE SB SM SE LB LM LE

HB 2.516 1.127 0.106 0.488 0.025 0.001 0.065 0.161 -0.118

HM -1.874 1.415 0.587 0.050 0.064 0.007 -1.152 -0.851 0.253

HE -1.238 -1.054 0.105 -0.011 0.010 0.001 0.020 -0.103 0.127

SB -0.489 0.052 0.004 1.567 2.133 0.046 -0.021 -0.008 0.180

SM 0.027 0.074 0.011 -0.281 -0.929 -0.086 0.357 0.104 -0.210

SE 0.001 0.007 0.001 -0.033 -0.055 0.057 0.041 -0.107 0.013

LB 0.106 0.556 0.054 0.733 0.261 0.008 0.563 0.724 0.045

LM -0.365 0.251 0.091 0.112 -0.074 0.031 -1.844 -0.394 0.010

LE -0.864 0.095 0.141 0.100 -0.357 0.013 0.816 0.399 0.232

His-pro

HB HM HE SB SM SE LB LM LE

HB 1.113 0.734 0.164 -0.160 0.081 0.035 0.032 0.446 -0.082

HM 0.639 -0.264 0.064 0.036 0.023 0.004 0.103 -0.879 -0.139

HE -0.027 0.752 0.970 0.004 0.010 0.000 0.119 -0.038 -0.534

SB 0.069 0.495 0.004 0.960 1.170 -0.094 0.276 -0.125 -0.283

SM 0.020 0.073 0.010 0.719 0.598 -0.046 0.899 -0.974 -0.556

SE 0.001 0.005 0.000 0.124 0.405 0.117 0.007 0.021 0.025

LB 0.391 0.079 0.027 0.851 0.301 0.007 0.190 0.126 0.124

LM 0.345 -0.538 0.167 0.400 0.122 0.283 0.086 -0.579 -0.746

LE 0.053 0.170 0.049 0.069 -0.150 -0.159 -0.071 0.099 0.138

His-Asn

HB HM HE SB SM SE LB LM LE

HB 1.033 1.580 0.158 0.081 -0.030 0.001 -0.732 -0.112 0.051

HM -0.102 -1.605 0.701 -0.198 -0.098 0.006 0.139 -1.647 -0.129

HE 0.205 1.363 0.226 0.005 0.009 0.066 0.015 0.321 -0.378

SB 0.078 0.039 0.005 0.186 0.313 -0.149 0.054 -0.804 0.071

SM 0.021 -0.446 0.009 0.589 0.202 0.280 0.064 0.192 0.474

SE 0.001 0.005 0.000 0.218 0.128 0.163 0.007 0.020 0.010

LB 0.101 0.222 0.091 0.110 0.356 0.007 0.658 0.113 -0.129

LM 0.003 0.036 -0.576 -0.433 -0.570 -0.084 0.301 -0.960 -0.206

LE 0.051 0.048 -0.150 0.391 0.082 0.011 0.093 -0.905 0.157

His-Thr

HB HM HE SB SM SE LB LM LE

HB 1.894 1.557 0.021 -0.366 0.034 0.002 0.438 0.235 0.015

HM -2.882 -1.487 -0.518 -0.474 0.247 0.008 0.059 -0.254 0.172

HE 0.407 -0.498 0.362 -0.536 -0.101 0.001 0.014 -0.222 0.078

SB -0.037 0.036 0.004 1.481 0.834 0.144 0.184 0.857 -0.171

SM -0.114 0.127 0.011 -0.918 -1.257 -1.092 0.116 -0.140 -0.173

SE 0.002 0.005 0.001 0.290 -0.530 -0.069 0.007 0.020 0.010

LB 0.346 0.375 0.015 0.629 0.242 0.016 0.172 0.695 0.247

LM -0.071 -0.752 0.098 0.596 -0.100 0.021 -0.247 -0.737 0.245

LE -0.069 0.056 0.076 0.213 -0.591 0.332 0.082 -0.004 0.207

His-ser

HB HM HE SB SM SE LB LM LE

HB 2.370 1.778 0.355 0.101 0.027 0.001 0.757 0.343 0.348

HM -0.086 1.709 -1.719 0.258 0.047 0.006 -0.548 -0.313 0.219

HE -0.387 -0.473 -1.157 0.008 0.017 0.000 0.020 0.089 -0.471

SB 0.131 0.214 0.007 0.141 -0.207 0.280 0.312 0.175 0.111

SM 0.027 0.059 0.017 -0.390 -0.682 -0.843 -0.093 -0.244 -0.271

SE 0.002 0.005 0.000 0.217 -0.445 0.049 0.009 0.277 0.012

LB 0.061 -0.425 0.049 0.229 0.082 0.009 0.691 0.946 0.335

LM -0.124 -0.427 0.317 -0.038 -0.002 0.023 -1.826 -1.603 0.784

LE -0.706 0.134 0.222 -0.246 -0.150 0.012 -0.227 -1.925 0.196

His-Arg

HB HM HE SB SM SE LB LM LE

HB 2.052 1.773 0.078 0.055 0.020 0.001 0.525 0.105 0.009

HM 1.028 -0.203 0.235 0.038 0.031 0.007 0.271 -0.598 -2.422

HE 0.087 1.761 -2.284 0.003 -0.104 0.001 0.015 0.071 -0.582

SB 0.187 0.040 0.003 1.321 -0.489 -0.454 0.212 0.406 0.523

SM 0.021 0.025 0.085 1.166 -2.605 -0.674 0.077 0.436 0.210

SE 0.001 0.004 0.001 0.115 0.535 -0.042 0.007 0.148 -0.101

LB 0.268 -0.103 0.620 0.485 -0.097 0.008 0.483 -0.053 0.261

LM 0.221 0.078 -0.656 0.133 -0.069 0.020 0.882 0.147 -0.925

LE -0.115 0.035 -2.017 0.065 0.127 0.009 0.255 0.401 -0.350

His-Gln

HB HM HE SB SM SE LB LM LE

HB 0.693 0.668 0.367 0.056 0.015 0.001 0.237 0.015 0.050

HM 1.138 0.287 2.032 -0.003 -0.170 -0.025 0.218 0.397 0.143

HE 0.423 0.047 -0.800 0.003 0.007 0.001 0.012 0.051 -1.791

SB 0.133 0.059 0.003 0.338 0.581 0.075 0.201 0.547 0.079

SM 0.016 -0.061 0.007 1.151 0.477 -1.034 0.087 -0.118 -0.329

SE 0.001 -0.602 0.001 0.150 -0.230 0.021 0.005 0.015 0.008

LB 0.430 0.107 0.012 0.184 0.063 0.004 0.414 0.175 0.102

LM 0.329 -1.014 -0.969 0.085 -0.079 -0.089 -0.149 1.036 -0.787

LE -0.206 -0.101 -0.694 -0.012 0.031 0.008 0.086 0.061 0.280

His-Asp

HB HM HE SB SM SE LB LM LE

HB -0.016 2.493 -0.008 -0.249 0.085 0.001 -0.107 0.172 0.196

HM 0.580 -0.752 -1.131 0.040 -0.452 0.006 0.486 -1.586 -0.261

HE 0.094 2.079 0.117 0.003 0.009 0.000 0.015 0.073 0.040

SB 0.125 0.053 0.004 1.237 0.048 0.339 0.538 0.109 -0.090

SM -0.009 0.028 0.009 0.462 1.760 -0.660 -0.241 0.201 0.260

SE 0.001 0.005 0.000 0.642 0.352 -0.135 0.083 -0.220 0.008

LB 0.288 0.243 0.015 0.486 0.099 0.007 -0.504 0.289 0.120

LM -0.635 -0.071 -0.426 0.297 0.419 0.020 0.096 -1.127 0.408

LE 0.093 -0.758 0.031 0.062 -0.059 -0.004 -0.064 -0.832 0.030

His-Lys

HB HM HE SB SM SE LB LM LE

HB 1.355 2.020 -0.197 0.240 0.363 0.001 0.268 0.012 0.048

HM 1.649 -2.206 -0.410 0.206 0.198 -0.161 0.249 0.337 -2.389

HE 0.095 0.240 0.472 0.005 0.010 0.001 0.014 0.085 0.142

SB 0.510 0.139 0.005 1.411 -0.077 -0.036 0.315 0.248 -0.296

SM 0.022 -1.032 0.010 0.656 -0.674 -0.682 0.101 0.063 -1.839

SE 0.001 0.007 0.001 0.100 0.178 0.035 0.006 -0.003 -0.281

LB 0.387 0.363 -0.021 0.200 0.447 -0.002 0.833 0.588 0.372

LM 0.524 -0.182 0.245 0.215 0.319 -0.572 1.382 0.555 -1.844

LE 0.068 -1.186 -1.070 0.068 0.213 0.008 0.283 0.540 -0.443

His-Glu

HB HM HE SB SM SE LB LM LE

HB 0.936 1.420 0.089 0.088 0.022 0.001 0.455 -0.190 0.198

HM 0.709 0.996 2.557 0.040 0.102 0.008 0.470 0.542 -0.560

HE 0.177 -0.007 -0.833 0.006 -0.049 0.001 0.029 -0.075 -0.526

SB 0.071 -0.227 0.005 1.910 0.179 0.025 0.303 0.503 0.076

SM 0.062 0.038 0.011 0.608 0.287 0.112 -0.030 -0.109 -0.098

SE 0.001 0.008 0.001 -0.220 -0.089 0.056 0.063 0.024 0.010

LB 0.041 0.622 -0.018 -0.233 0.245 0.008 0.813 1.081 0.106

LM 0.089 -0.817 -0.057 0.347 -0.207 -0.350 0.886 -0.257 0.148

LE -0.120 0.039 0.078 -0.120 -0.161 0.010 0.125 0.076 0.311

Tyr-Tyr

HB HM HE SB SM SE LB LM LE

HB -1.023 0.627 -0.273 -0.109 0.023 0.001 0.145 -0.220 0.131

HM -1.266 0.098 0.047 -0.268 0.003 0.150 -0.854 0.111

HE 0.132 0.005 0.005 0.000 0.035 0.219 0.060

SB -0.965 -3.652 0.303 -0.503 -0.292 0.088

SM -2.987 -0.514 -0.454 -0.341 -0.138

SE 0.047 0.080 -0.161 -0.769

LB 0.075 -1.655 -0.067

LM -1.415 -0.672

LE -0.355

Tyr-ala

HB HM HE SB SM SE LB LM LE

HB -2.377 0.595 -0.111 -0.126 0.044 0.003 -0.241 0.601 0.034

HM -8.146 0.436 2.690 -0.184 0.053 0.005 -0.369 0.353 0.331

HE 0.437 0.199 1.847 0.007 0.021 0.000 0.024 0.106 0.090

SB -0.122 -0.247 0.007 0.357 1.613 -0.616 -0.322 -0.314 -0.048

SM -0.491 -1.293 0.026 -0.014 -1.307 0.569 -0.474 -2.208 -0.381

SE 0.004 0.005 0.000 -1.105 0.324 -0.650 -1.112 0.054 0.035

LB -2.014 0.392 0.054 0.504 0.091 0.014 -0.077 0.725 0.134

LM 0.263 -0.719 0.061 -0.565 0.936 0.054 -1.143 0.694 -1.432

LE 0.170 0.312 -0.158 0.164 0.239 0.035 0.215 0.860 -0.189

Tyr-gly

HB HM HE SB SM SE LB LM LE

HB -2.526 0.670 0.129 0.230 0.042 0.002 -0.905 -0.846 -0.304

HM -1.787 1.317 1.087 -0.058 0.065 0.067 -0.369 -0.686 0.280

HE -0.186 0.279 -0.046 0.008 0.011 0.001 0.028 0.115 0.318

SB -0.308 -0.136 0.006 1.086 -0.074 0.618 -0.754 -0.703 1.060

SM 0.040 -0.982 -0.087 -4.263 -3.379 0.521 -0.991 -1.196 -0.141

SE 0.003 0.006 0.001 -1.143 -2.136 0.161 0.036 -0.002 -0.667

LB -0.242 0.246 0.203 -0.157 -0.014 0.015 0.538 0.795 -0.357

LM -0.103 0.430 0.108 -0.097 0.809 0.067 -2.326 -0.713 0.402

LE 0.021 -0.347 0.217 -0.187 0.173 0.081 -0.297 -0.742 -0.093

Tyr-pro

HB HM HE SB SM SE LB LM LE

HB 1.160 1.801 -0.053 0.081 0.048 0.002 -0.436 -1.998 -0.668

HM 0.088 0.124 0.581 -0.535 0.036 0.003 -0.315 -0.972 0.766

HE 0.101 0.394 0.669 0.006 0.010 0.000 0.018 -0.040 0.086

SB 0.191 -0.316 0.007 1.642 0.583 -0.789 -0.026 0.239 -0.040

SM -0.164 0.058 0.009 0.483 1.889 -0.433 -0.320 -2.286 -0.097

SE 0.002 0.005 0.000 0.198 0.392 0.076 0.009 -0.213 0.020

LB 0.216 0.185 0.000 -0.044 0.136 0.009 0.486 -0.100 -0.138

LM -0.500 -0.184 0.016 -0.133 -0.016 0.040 0.818 -0.409 -0.225

LE 0.285 0.041 -0.395 0.145 0.162 0.020 -0.032 -0.712 0.371

Tyr-asn

HB HM HE SB SM SE LB LM LE

HB 0.552 -0.569 -0.134 0.453 -0.106 0.002 0.079 -0.069 -0.331

HM 0.878 -0.663 0.201 0.231 0.007 0.004 0.144 -0.035 0.012

HE 0.144 0.450 -0.080 0.009 0.012 0.000 0.065 -0.219 0.061

SB -0.022 -0.057 0.064 3.255 -0.011 -0.504 -0.568 -0.409 -0.400

SM 0.034 -0.085 0.036 0.656 0.682 0.015 -1.880 -1.314 -0.104

SE 0.002 0.004 0.000 0.257 0.002 0.125 0.034 0.120 -0.770

LB 0.228 -0.181 0.022 0.652 -0.159 0.010 0.216 -0.284 -0.061

LM -0.031 -0.157 0.088 0.590 0.169 0.097 1.085 -1.840 -0.392

LE 0.091 -0.159 0.058 0.125 0.206 0.031 0.035 0.295 -0.205

Tyr-Thr

HB HM HE SB SM SE LB LM LE

HB 0.945 0.452 -0.137 -0.097 -0.040 0.002 -0.017 0.384 -0.250

HM -2.113 1.729 0.702 -0.020 0.421 0.004 -0.266 -0.296 -0.655

HE 0.563 0.862 -0.219 0.007 -0.210 0.001 0.113 0.127 -0.503

SB -0.218 -0.203 0.007 0.811 -0.686 0.048 0.624 -0.130 -0.282

SM -0.150 0.155 0.253 -1.146 -2.819 -1.529 0.342 -0.312 -0.206

SE 0.002 0.004 0.001 -2.982 -0.215 0.101 -0.098 -0.123 -0.100

LB -0.045 0.026 -0.109 0.362 -0.173 0.011 0.740 0.220 0.178

LM 0.221 0.158 -0.805 -0.481 0.346 -0.068 -0.736 -0.298 -0.343

LE 0.097 -0.062 0.341 0.160 0.063 0.034 0.123 0.394 -0.340

Tyr-ser

HB HM HE SB SM SE LB LM LE

HB -1.006 0.737 0.310 0.322 -0.496 0.002 0.354 0.515 0.303

HM -0.915 1.306 0.587 -0.132 0.145 0.005 -0.025 0.091 -0.330

HE -0.166 -0.920 1.059 0.009 0.017 0.000 0.056 -0.118 0.262

SB -0.337 0.316 -0.102 2.400 0.558 0.485 -0.780 -0.744 0.077

SM -0.373 -1.413 0.016 -1.604 0.235 -0.171 -0.236 -0.305 -0.219

SE 0.002 0.006 0.000 -0.195 0.658 0.117 0.015 0.186 0.125

LB -0.346 -0.212 0.027 0.324 0.172 0.017 -0.295 0.641 0.212

LM -0.584 -0.866 -0.064 -0.375 0.731 0.065 0.323 0.653 0.992

LE -0.128 0.188 0.092 0.156 0.595 0.041 -0.471 0.564 0.324

Tyr-arg

HB HM HE SB SM SE LB LM LE

HB 1.325 -0.058 -0.505 0.148 0.028 0.002 0.276 -0.761 0.082

HM 1.521 -0.565 -2.383 0.048 0.046 0.004 0.429 -0.043 0.091

HE 0.272 -0.145 -0.393 0.004 0.009 0.000 0.030 0.151 0.124

SB 0.074 -0.130 0.004 2.533 -3.006 -1.303 0.454 -0.603 -0.811

SM 0.027 -0.046 -0.087 0.535 -2.038 -1.326 0.262 0.108 -0.157

SE 0.001 0.004 0.000 0.156 0.097 0.085 0.032 0.045 0.025

LB 0.458 -0.604 0.056 0.713 -0.159 0.010 1.313 0.228 0.004

LM -0.019 -0.579 -0.335 -0.094 -1.608 0.114 1.112 -1.319 -2.474

LE 0.221 0.553 -0.038 -0.009 -0.048 0.025 0.259 0.552 0.037

Tyr-gln

HB HM HE SB SM SE LB LM LE

HB 1.391 -0.311 0.546 -0.098 0.022 0.001 -0.683 -0.140 -0.331

HM -0.029 -1.045 0.734 0.036 0.027 0.003 0.513 0.472 -0.034

HE 0.094 0.089 1.040 0.007 0.007 0.000 0.017 0.189 0.174

SB 0.209 -0.364 0.018 1.408 -0.578 -1.674 0.255 -0.312 -0.555

SM 0.019 -0.360 0.007 0.624 -0.556 -0.286 -0.152 -0.277 0.382

SE 0.001 0.003 0.000 -0.033 0.374 0.064 0.007 0.031 0.022

LB 0.236 -0.874 0.018 0.143 -0.056 -0.059 0.886 0.711 -0.513

LM 0.417 -0.210 -1.149 0.442 0.444 0.032 0.663 0.464 -0.049

LE 0.060 0.081 0.065 0.084 -0.328 0.022 0.142 0.341 0.150

Tyr-asp

HB HM HE SB SM SE LB LM LE

HB 1.860 1.228 0.525 0.135 0.035 0.002 0.607 0.518 0.084

HM 0.861 -0.256 -0.062 0.062 0.030 0.004 0.256 0.367 -0.499

HE 0.296 0.721 0.882 0.005 0.012 0.000 0.118 0.174 -0.910

SB 0.039 -0.307 0.564 1.741 0.331 0.203 0.050 -1.083 0.245

SM -0.621 -0.034 0.012 0.975 0.879 0.668 0.209 -1.495 -0.231

SE 0.002 0.004 0.000 0.416 0.475 -0.065 0.186 0.066 0.029

LB -0.031 0.341 0.022 0.028 0.144 0.010 0.398 -0.145 0.558

LM -0.471 0.230 0.201 0.396 0.576 0.056 0.574 0.286 -0.053

LE 0.136 0.331 0.165 0.004 0.248 0.030 0.190 -0.547 -0.499

Tyr-lys

HB HM HE SB SM SE LB LM LE

HB 1.735 1.159 -1.096 0.150 0.031 0.002 0.575 0.410 -2.178

HM 1.036 -0.412 1.317 0.151 -0.222 0.004 0.366 0.719 -1.866

HE 0.136 0.539 1.231 0.007 0.012 0.001 0.022 0.454 0.235

SB 0.084 -0.588 0.007 2.135 -2.248 -2.481 0.482 -0.484 -0.691

SM 0.080 -0.122 -0.287 0.963 -2.922 -1.923 -0.002 -0.328 -1.109

SE 0.002 0.004 0.001 0.223 0.447 -0.354 0.011 0.052 0.111

LB 0.203 0.115 -0.246 0.697 -0.218 0.009 1.069 -1.462 -0.795

LM 0.382 -0.843 -0.157 0.430 0.166 -0.175 1.189 -2.563 -1.197

LE 0.092 0.589 0.226 0.219 0.076 0.026 0.280 0.035 -1.188

Tyr-glu

HB HM HE SB SM SE LB LM LE

HB 1.937 -0.444 -0.173 0.137 0.030 0.002 0.690 0.926 0.148

HM 0.009 0.308 1.880 0.183 0.084 0.004 0.157 0.850 0.100

HE -0.178 0.977 0.038 0.009 0.011 0.001 0.057 -0.288 0.216

SB 0.079 0.148 0.008 1.153 -1.668 -0.936 0.320 0.324 0.331

SM 0.031 -0.329 0.010 0.409 -0.840 -0.474 0.821 -1.444 0.162

SE 0.003 0.006 0.001 -0.726 -1.655 -0.811 0.012 0.195 0.024

LB -0.050 -0.763 0.021 0.276 0.124 -0.173 1.275 -0.854 0.157

LM 0.520 0.672 -0.337 -0.363 0.242 -0.052 0.312 -0.643 0.192

LE 0.097 0.322 0.050 0.165 0.182 0.024 0.254 0.294 -0.447

Ala-ala

HB HM HE SB SM SE LB LM LE

HB -6.030 -2.784 -0.555 -3.437 -0.336 0.008 -1.792 1.272 -0.989

HM -3.941 -3.715 -0.404 0.319 0.016 -0.303 1.508 -0.952

HE -1.344 0.019 0.030 0.001 0.206 0.100 -0.948

SB -2.769 0.986 0.154 -0.123 0.270 -0.333

SM 1.123 -0.110 -0.213 1.014 0.316

SE 0.126 -0.005 0.124 0.050

LB 1.065 1.399 0.215

LM 0.027 0.356

LE 0.135

Ala-gly

HB HM HE SB SM SE LB LM LE

HB -0.155 4.506 -1.504 -2.891 0.068 0.004 -3.962 -0.979 -3.250

HM 2.529 0.072 1.695 -0.056 0.137 0.020 -0.395 -4.896 -2.490

HE -0.950 -0.593 0.976 -0.079 0.024 0.001 -0.291 -0.734 -0.874

SB -0.040 -0.403 0.014 -0.653 -0.229 0.581 0.769 -0.907 -0.057

SM 0.182 0.158 0.024 1.917 1.526 1.223 0.558 1.504 0.256

SE -0.017 0.018 0.001 0.320 -0.094 -0.024 0.031 0.057 -0.484

LB 0.599 0.194 0.054 0.037 -0.055 0.030 0.387 -0.431 -0.122

LM 0.804 1.241 0.218 1.395 1.617 0.249 -1.685 -3.456 0.497

LE -0.401 0.287 0.707 -0.270 0.212 -0.331 -1.132 0.805 0.634

Ala-pro

HB HM HE SB SM SE LB LM LE

HB 3.431 2.378 -0.107 -0.449 -0.415 -0.004 -0.195 -0.416 -0.933

HM 2.497 3.157 1.005 0.086 -0.266 0.010 0.595 -1.148 -0.602

HE 0.217 -0.043 -0.501 0.013 -0.217 0.001 0.048 -0.112 -1.284

SB 0.101 0.161 0.012 2.275 1.852 0.035 -1.883 -1.210 -0.385

SM -0.050 0.077 0.022 1.084 0.853 0.332 0.362 0.323 0.078

SE 0.003 0.010 0.001 0.629 0.533 0.019 0.022 -0.461 -0.995

LB 0.611 0.188 0.038 0.604 0.391 0.269 1.050 0.408 -0.452

LM 1.344 0.383 -0.554 0.761 0.453 -0.124 -0.053 -1.029 -0.783

LE 0.045 0.038 0.123 0.104 0.205 0.030 0.115 0.069 -0.800

Ala-asn

HB HM HE SB SM SE LB LM LE

HB 2.516 -1.714 -0.879 -0.028 -0.166 0.000 -0.082 -4.119 -0.705

HM 2.030 -2.018 -0.880 0.110 0.258 0.009 0.690 -1.482 -0.479

HE 0.054 0.660 1.564 0.014 -0.073 0.001 0.085 -0.245 -2.887

SB 0.223 0.072 -0.177 3.603 -0.208 -0.535 -1.190 -0.589 0.004

SM 0.069 -0.292 0.024 2.176 1.821 0.683 0.777 0.857 -0.077

SE 0.004 0.012 0.001 0.697 0.466 -0.851 0.060 0.085 0.039

LB 0.466 -0.239 0.059 0.584 0.345 -0.033 1.409 -1.274 -0.855

LM 0.599 1.363 0.799 0.660 -1.068 0.112 0.365 0.866 -1.222

LE 0.222 -0.847 0.242 0.238 0.025 0.039 0.406 0.419 -0.007

Ala-thr

HB HM HE SB SM SE LB LM LE

HB -1.641 -3.140 -1.340 -1.270 -0.156 -0.249 -0.856 1.460 -0.515

HM 2.589 -2.226 0.759 0.660 -0.301 -0.001 0.374 0.026 0.098

HE 0.480 0.809 -2.331 0.472 0.022 0.001 -0.009 0.038 -0.380

SB -0.005 -0.161 0.015 3.758 0.189 -0.759 -0.202 -1.324 -0.446

SM 0.150 0.305 0.056 2.099 1.503 -0.034 0.365 0.223 0.440

SE 0.004 0.011 0.001 0.161 -0.008 0.259 0.022 0.092 0.041

LB -0.336 -0.162 0.177 -0.108 -0.873 -0.120 0.295 -0.818 -0.440

LM 1.122 0.648 0.371 0.583 0.517 -0.152 0.974 -0.424 -0.937

LE 0.129 -1.184 0.123 0.136 -0.994 -0.305 0.389 0.150 0.352

Ala-ser

HB HM HE SB SM SE LB LM LE

HB 0.377 -1.876 2.058 -0.981 -0.760 -0.098 -0.733 1.219 -0.480

HM 0.507 -2.889 -0.343 -0.581 0.063 0.006 0.489 -1.207 -3.155

HE 1.137 -2.240 -1.163 0.019 0.034 0.001 -0.684 0.832 -0.306

SB -0.115 -0.061 0.009 2.299 -1.191 -1.424 0.266 0.281 0.417

SM 0.092 -0.074 -0.059 1.227 2.285 0.803 0.408 0.202 0.329

SE 0.006 0.069 0.064 -0.167 0.350 0.240 0.098 -0.589 -0.490

LB 0.102 -0.066 0.400 0.338 0.335 0.028 -0.525 -0.410 -0.538

LM 0.589 -1.120 -0.657 1.015 0.354 0.099 0.158 0.480 -0.584

LE 0.040 0.567 -1.136 0.261 0.405 0.052 -0.329 0.373 1.536

Ala-arg

HB HM HE SB SM SE LB LM LE

HB 3.606 -7.619 -3.687 0.095 0.031 0.003 1.586 -0.863 -0.508

HM 2.880 1.939 -5.534 0.087 -0.026 -0.093 0.741 0.845 -0.242

HE 0.500 -1.185 -3.387 0.009 -0.091 0.001 0.037 0.197 0.790

SB 0.234 -0.022 0.010 2.728 -0.190 -2.387 0.729 -0.719 0.108

SM 0.058 -0.036 0.021 1.600 0.803 0.237 0.393 -0.377 0.048

SE 0.003 0.012 0.031 0.475 0.649 0.190 0.023 0.069 0.038

LB 0.433 -0.956 -0.725 0.270 -0.729 -0.063 0.937 -0.637 -2.385

LM 0.946 0.411 -1.085 0.717 -0.906 -0.100 1.573 0.666 -1.685

LE 0.226 0.067 0.107 0.175 0.154 0.051 0.525 -0.944 0.523

Ala-gln

HB HM HE SB SM SE LB LM LE

HB -0.169 -1.287 -0.342 0.152 -0.024 0.003 0.159 0.910 -1.020

HM 3.075 -0.278 -5.841 0.069 0.040 -0.300 0.607 0.169 -0.417

HE 0.517 1.092 -1.032 -0.155 0.071 0.001 0.185 -0.005 -0.048

SB 0.129 -0.417 0.010 0.417 0.138 -1.109 0.228 -0.100 -0.480

SM 0.100 0.050 -0.180 1.149 1.309 -0.125 0.287 -0.264 -0.198

SE 0.103 0.037 0.001 0.306 0.592 0.249 0.055 0.046 0.028

LB 0.757 -0.507 0.760 0.615 0.086 0.157 0.773 0.857 -0.079

LM -0.620 0.579 -0.404 0.283 0.292 0.110 1.233 0.889 -0.107

LE 0.171 -1.481 -0.197 0.120 -0.263 0.274 0.198 -0.689 0.512

Ala-asp

HB HM HE SB SM SE LB LM LE

HB 2.160 0.980 -0.486 0.721 0.190 0.004 1.416 0.022 -1.605

HM 1.886 -0.790 -0.113 0.307 -0.591 0.062 0.626 -0.136 1.112

HE -0.636 0.720 -3.248 0.012 0.025 0.001 0.064 0.614 -0.016

SB 0.439 0.257 -0.007 2.886 0.477 0.408 0.707 -0.395 -0.562

SM 0.238 -0.721 0.009 0.893 0.146 0.481 -0.471 1.391 0.110

SE 0.004 0.043 0.001 0.472 0.337 0.146 0.021 0.132 0.001

LB -0.054 0.256 -0.090 0.545 0.642 -0.486 0.662 -0.082 -0.418

LM 0.555 -0.329 -0.673 0.263 -0.248 0.069 1.469 -0.526 -0.920

LE -0.384 0.366 -1.203 0.410 -0.550 -0.013 0.531 -0.823 -1.438

Ala-lys

HB HM HE SB SM SE LB LM LE

HB 4.473 -2.834 -3.849 0.504 0.121 0.004 1.412 -2.122 -0.777

HM 4.108 0.900 -8.378 0.091 -0.168 -0.133 0.665 1.453 -2.531

HE 0.739 1.667 0.314 0.012 0.111 0.001 0.034 0.375 -0.098

SB 0.013 -0.408 -0.290 4.118 0.430 -0.894 0.932 1.032 -1.058

SM 0.067 0.107 -0.139 2.543 0.031 -2.146 0.674 0.093 0.136

SE 0.004 0.014 0.001 0.428 1.134 -1.076 0.018 0.057 0.063

LB 0.880 -1.786 -0.260 0.837 -0.794 0.028 1.604 -0.150 -1.111

LM 0.374 -1.285 -1.388 0.404 -0.829 -0.190 2.112 -0.577 -2.185

LE 0.233 0.408 -0.497 0.334 -0.482 -0.353 0.479 0.590 0.212

Ala-glu

HB HM HE SB SM SE LB LM LE

HB 0.772 -2.055 -1.913 0.199 0.050 0.005 0.546 0.303 -0.268

HM 3.539 1.115 -7.887 0.101 0.185 -0.134 1.169 1.213 0.048

HE 0.569 -0.422 -2.640 0.013 0.060 0.021 0.355 0.248 0.019

SB -0.135 0.287 0.013 4.112 -0.475 -0.551 0.755 0.449 -0.425

SM 0.149 0.149 0.023 2.102 -0.221 0.383 0.410 0.372 0.404

SE 0.005 0.023 0.001 0.229 0.294 0.166 -0.038 -0.114 -0.094

LB -0.387 -0.928 -0.061 0.171 0.019 -0.038 1.427 1.287 -0.056

LM -0.286 -1.203 -0.535 0.730 -0.108 -0.353 0.645 -0.051 -0.516

LE 0.096 -0.327 0.024 -0.298 0.180 -0.119 0.879 -1.352 -0.438

Gly-gly

HB HM HE SB SM SE LB LM LE

HB 0.243 0.651 0.238 -0.027 0.087 0.004 -1.036 -0.043 -1.605

HM 0.388 0.192 -0.032 0.236 0.018 0.119 -0.060 -0.351

HE 1.277 0.011 0.022 0.002 -0.396 -0.029 -0.807

SB -0.360 0.002 0.790 -0.074 -0.251 0.403

SM 0.940 0.084 0.074 1.266 0.650

SE 0.147 0.137 0.276 0.002

LB -0.965 -1.230 -0.749

LM -0.391 0.537

LE 0.878

Gly-pro

HB HM HE SB SM SE LB LM LE

HB 2.939 1.750 0.284 0.620 0.078 0.002 -0.306 -0.411 0.802

HM 1.172 1.652 1.730 0.079 0.072 0.013 0.232 -1.305 -0.294

HE 0.021 1.581 1.435 0.009 0.016 0.001 0.037 0.448 -0.270

SB 0.461 0.101 0.009 4.136 1.505 0.154 0.165 -1.044 -0.061

SM 0.051 0.071 0.016 0.511 1.795 -1.116 0.116 -0.333 0.326

SE 0.003 0.013 0.001 1.145 0.327 0.286 -0.095 0.067 0.034

LB -0.287 -0.023 0.035 0.664 0.355 -0.132 -0.856 -1.849 -0.976

LM 0.309 0.528 -0.446 1.310 -0.015 -0.464 1.643 -1.635 -2.193

LE 0.126 -0.127 0.087 0.341 0.094 -0.180 0.092 -1.018 -1.129

Gly-asn

HB HM HE SB SM SE LB LM LE

HB 1.112 1.033 0.670 -0.196 0.060 0.002 0.239 -0.352 -0.062

HM 2.507 -0.726 -1.084 0.073 0.007 0.011 0.628 -0.180 0.174

HE -0.509 1.180 0.094 0.014 0.020 -0.009 0.059 0.501 0.281

SB 0.145 0.013 0.011 3.057 0.532 0.192 0.037 -1.333 -0.480

SM 0.063 0.177 0.019 1.561 1.078 0.444 0.556 -0.047 -0.297

SE 0.003 0.012 0.001 0.534 0.757 -0.637 0.019 0.077 0.046

LB -0.262 -1.135 -1.190 0.196 -0.069 0.019 -0.594 -1.470 -0.379

LM 0.401 -1.394 -0.442 -0.128 -0.779 -0.334 0.717 -1.408 -1.351

LE 0.391 -0.011 0.045 0.120 -0.816 0.140 0.622 -0.956 -1.334

Gly-thr

HB HM HE SB SM SE LB LM LE

HB -1.905 2.071 -0.246 -0.727 -0.126 -0.335 0.760 0.488 -0.652

HM 2.126 -0.240 -1.920 0.000 -0.093 0.012 0.540 -0.101 -0.546

HE 0.427 2.801 1.835 0.011 0.017 0.002 0.042 -0.198 0.131

SB 0.155 -0.303 0.158 2.458 3.012 -0.941 0.239 0.596 0.170

SM -0.098 0.034 0.018 -1.013 2.498 0.270 0.358 -0.346 0.444

SE 0.003 0.015 0.002 0.661 0.650 0.004 0.020 0.207 0.052

LB -0.446 0.486 -0.370 -0.082 -0.073 -0.056 -0.821 -2.129 -1.238

LM -0.780 0.288 0.070 -0.319 -0.856 -1.188 -0.070 -1.893 -0.684

LE 0.020 -0.254 -1.487 -0.230 -0.163 -1.042 0.161 -2.010 0.366

Gly-ser

HB HM HE SB SM SE LB LM LE

HB -1.574 0.991 0.276 0.045 0.088 0.005 -1.186 0.129 -0.152

HM 1.947 2.544 -6.070 -0.426 -0.090 0.016 0.264 0.965 -0.418

HE 0.076 2.940 3.592 0.017 -0.553 0.001 -0.285 -0.373 0.112

SB -0.226 0.472 0.015 -0.128 -0.627 0.854 0.322 1.286 0.188

SM 0.107 0.126 0.029 1.579 1.713 0.315 0.435 0.162 0.059

SE 0.004 0.015 0.001 0.647 1.121 -0.310 -0.009 0.103 0.254

LB -0.877 -0.324 0.299 -1.213 0.275 0.032 -1.569 -0.576 -0.344

LM -0.091 -1.086 0.310 -0.514 -0.848 0.090 0.217 -2.332 -5.378

LE 0.314 -1.511 -2.475 0.203 -0.251 0.055 -0.502 0.293 -0.021

Gly-arg

HB HM HE SB SM SE LB LM LE

HB 3.058 -2.488 0.235 0.155 0.062 0.003 1.045 -0.328 -0.089

HM 1.723 3.071 0.304 0.089 0.187 -0.070 0.491 1.168 0.538

HE 0.590 0.407 -0.796 0.008 0.017 -0.001 0.036 0.115 0.121

SB 0.263 -0.518 0.252 3.542 -0.261 -0.972 0.930 -0.864 -0.560

SM 0.058 -0.625 -0.044 2.140 1.656 -2.837 0.235 0.983 0.078

SE 0.003 0.012 0.001 0.674 0.540 -0.364 0.147 -0.101 0.041

LB -0.544 -1.872 -0.914 0.376 -1.627 0.108 1.049 -2.583 -1.113

LM 0.632 0.651 -0.653 0.662 -2.011 -2.674 0.862 0.198 -1.862

LE -0.183 -0.556 -0.864 0.170 0.203 -0.065 0.405 -0.426 -0.210

Gly-gln

HB HM HE SB SM SE LB LM LE

HB -0.652 0.813 -0.437 0.025 -0.296 0.003 0.407 0.459 0.139

HM 2.093 2.596 -5.669 0.028 -0.093 0.008 0.572 0.679 0.241

HE -0.145 1.982 0.659 0.009 0.013 0.002 0.030 0.315 0.145

SB 0.207 0.007 0.009 2.086 -1.851 0.689 0.497 0.055 0.223

SM 0.058 0.017 0.062 1.840 -1.784 0.073 0.381 0.833 0.204

SE 0.002 0.069 0.002 0.306 0.941 0.202 0.053 0.053 0.034

LB -2.135 -0.728 -0.154 0.570 -1.070 0.081 1.007 -0.513 -1.492

LM 0.429 -2.089 -0.312 0.850 -2.598 0.015 1.549 -0.730 -1.393

LE 0.093 0.753 0.093 0.164 -0.245 0.050 0.383 0.710 -1.797

Gly-asp

HB HM HE SB SM SE LB LM LE

HB 1.969 2.407 0.014 -0.258 0.065 0.004 0.332 -0.266 -0.749

HM 2.414 1.648 -1.729 0.180 -0.288 0.014 0.448 0.808 -0.460

HE 0.120 2.247 -0.532 0.010 -0.091 0.001 0.095 0.180 -0.265

SB -0.190 0.098 -0.156 2.041 0.378 0.182 0.451 1.227 -0.179

SM 0.179 -0.250 0.002 2.366 2.516 0.945 0.485 0.820 0.059

SE 0.004 0.015 0.001 0.994 1.298 0.199 0.020 0.183 0.045

LB 0.151 -2.037 0.013 0.829 -0.467 0.083 -1.308 -2.592 -0.671

LM 0.645 -1.948 -0.018 0.453 -0.520 -0.970 0.530 -2.299 -1.376

LE 0.159 -0.745 -0.630 0.531 0.106 0.045 -0.435 -0.660 0.085

Gly-lys

HB HM HE SB SM SE LB LM LE

HB 2.810 2.030 -1.019 -0.048 -0.044 -0.043 0.786 0.490 -0.602

HM 2.726 2.154 -5.924 -0.201 0.099 -0.058 0.418 0.891 -0.538

HE 0.342 3.258 1.674 0.010 0.018 0.002 0.209 0.196 -0.194

SB 0.199 0.499 -0.220 3.976 1.003 -1.484 0.706 0.545 -0.323

SM -0.013 0.102 0.019 1.734 -0.268 -1.275 0.247 0.838 0.045

SE 0.004 0.049 0.002 0.412 0.691 0.014 0.015 0.111 0.128

LB 0.700 -1.540 0.009 1.191 0.065 -0.361 2.083 -0.368 -1.805

LM 1.142 -1.017 -2.500 1.299 -0.396 -0.127 2.222 1.232 -0.612

LE 0.634 -1.708 -0.846 0.199 -0.191 -0.374 0.437 1.250 -0.176

Gly-glu

HB HM HE SB SM SE LB LM LE

HB 2.577 1.123 0.086 0.055 -0.010 0.006 0.937 -0.333 -0.090

HM 1.365 -0.186 -0.887 0.105 0.083 -0.022 0.433 0.914 -0.080

HE 0.352 1.975 0.718 0.011 0.019 0.002 0.037 0.096 0.232

SB 0.056 0.234 -0.033 2.507 0.893 -1.322 0.739 -0.109 -0.476

SM 0.061 0.225 0.019 1.360 2.041 -0.328 0.157 1.395 0.111

SE 0.003 0.014 0.002 0.637 1.051 0.116 0.023 0.210 0.040

LB -0.061 -0.561 0.308 -0.233 -0.632 -0.162 1.833 0.330 -0.428

LM 0.501 -0.970 -0.991 0.258 -0.586 0.039 1.580 -0.480 -1.640

LE -0.168 -2.114 0.409 0.241 -0.517 0.294 0.790 0.777 0.026

Pro-Pro

HB HM HE SB SM SE LB LM LE

HB 0.994 1.892 0.222 0.141 0.039 0.002 0.543 -0.213 0.684

HM 1.089 1.119 0.125 0.169 0.006 0.283 0.256 0.175

HE 0.718 -0.022 -0.049 -0.033 0.022 0.094 0.223

SB 1.435 1.833 0.165 0.409 1.086 0.298

SM 0.744 0.093 0.178 0.677 0.238

SE 0.041 0.017 -0.378 -0.019

LB -0.095 -0.025 0.128

LM -0.699 -0.551

LE -0.570

Pro-Asn

HB HM HE SB SM SE LB LM LE

HB 1.826 0.951 0.379 0.139 0.041 0.002 0.550 0.375 0.099

HM 0.591 0.105 0.109 0.177 0.056 0.007 0.009 0.431 -0.213

HE 0.026 0.499 0.558 0.010 0.225 0.001 0.144 0.088 -0.035

SB 0.151 0.062 0.010 2.212 1.826 0.318 0.847 0.325 0.322

SM 0.036 -0.060 0.018 1.987 1.050 0.198 0.233 0.187 0.252

SE 0.003 0.007 0.001 0.431 -0.115 0.114 0.012 0.123 0.127

LB 0.633 -0.302 0.049 0.030 -0.060 -0.051 1.053 -0.148 0.222

LM 0.171 -0.311 0.030 -0.216 -2.419 0.054 0.558 1.919 -0.276

LE 0.042 -0.322 -0.335 -0.279 0.154 -0.643 0.280 -0.724 -0.638

Pro-Thr

HB HM HE SB SM SE LB LM LE

HB 2.682 1.788 0.254 0.039 0.075 0.003 0.215 0.623 0.098

HM -0.030 3.248 0.413 -0.107 -0.145 0.008 0.043 -0.101 0.389

HE 0.939 1.712 0.184 0.009 0.017 0.001 0.284 -0.173 0.093

SB 0.121 0.005 0.010 3.030 1.592 0.572 1.098 0.595 0.145

SM 0.016 0.058 0.110 1.666 1.491 -0.234 -0.061 0.490 -0.434

SE 0.004 0.008 0.036 0.171 0.526 -0.152 0.036 -0.152 -0.049

LB -0.179 0.249 0.030 -0.072 0.021 0.030 -0.107 1.087 -0.025

LM -1.305 0.629 0.013 0.273 -0.103 -0.531 1.174 -0.693 0.216

LE 0.715 0.286 0.376 -0.080 -1.176 0.043 0.003 0.305 0.378

Pro-Ser

HB HM HE SB SM SE LB LM LE

HB 1.165 2.156 0.686 0.056 0.146 0.003 0.968 0.826 0.287

HM 2.626 2.853 1.354 -0.533 0.070 0.010 0.474 1.039 -0.449

HE 0.955 0.210 -0.227 0.001 0.026 0.001 0.035 0.215 0.302

SB -0.049 0.324 0.014 3.691 1.324 0.366 0.715 0.792 -0.044

SM 0.420 -0.137 0.025 2.019 2.249 0.262 -0.044 0.442 0.156

SE 0.004 0.010 0.001 0.311 -0.061 0.081 0.018 0.106 0.031

LB -0.516 0.353 0.018 0.548 -0.216 0.018 -0.537 1.921 -0.319

LM -0.251 -0.194 -0.191 -0.374 0.482 0.097 -0.660 -0.480 1.188

LE 0.183 -0.339 -0.036 -0.429 -0.344 0.026 -0.167 -2.641 -1.649

Pro-Arg

HB HM HE SB SM SE LB LM LE

HB 2.274 2.160 0.415 0.135 0.038 0.069 0.543 0.520 0.290

HM 0.735 0.811 0.209 0.188 0.102 0.008 0.501 0.736 -0.060

HE 0.237 0.473 0.375 0.007 0.014 0.001 0.038 0.222 0.166

SB 0.268 -0.597 0.006 2.824 1.100 -0.071 0.672 0.068 0.168

SM 0.036 0.188 0.015 1.114 1.049 0.085 0.363 0.154 -0.287

SE 0.002 0.010 0.001 0.464 0.014 -0.299 0.018 -0.217 0.027

LB -0.188 0.110 0.026 0.625 0.004 0.006 0.955 0.369 -0.293

LM 0.234 -0.212 -1.234 0.742 -1.174 0.054 0.987 -0.509 -0.951

LE 0.105 -0.650 -0.533 0.118 -0.554 0.067 0.328 -0.584 0.338

Pro-Gln

HB HM HE SB SM SE LB LM LE

HB 1.290 1.087 0.735 0.109 -0.087 0.005 0.499 0.455 0.060

HM 0.266 1.090 1.265 0.068 0.035 0.005 0.378 0.187 0.208

HE 0.231 -0.435 -0.479 0.007 0.012 0.001 0.022 0.029 -0.024

SB 0.109 0.032 0.007 2.175 1.166 0.466 0.641 -0.385 0.093

SM 0.077 0.035 -0.109 1.251 1.696 -0.065 0.132 -0.257 -2.605

SE 0.002 0.005 0.001 0.541 -0.267 0.069 0.010 0.034 0.020

LB -0.168 0.308 -0.069 0.367 0.276 0.127 1.097 -0.503 0.210

LM -0.510 -0.868 -1.533 0.698 -0.743 -0.213 1.550 0.275 -0.055

LE -0.177 -0.546 -0.124 0.307 -1.153 -0.106 0.239 -1.053 -1.425

Pro-Asp

HB HM HE SB SM SE LB LM LE

HB 1.772 1.856 0.183 0.283 0.046 0.002 0.874 0.835 0.008

HM 1.589 4.032 1.227 0.068 0.061 0.009 0.348 0.704 -0.810

HE 0.083 0.577 0.708 0.008 0.162 0.000 0.092 0.243 -0.691

SB 0.182 0.057 0.010 2.974 1.291 0.380 0.454 0.693 0.153

SM 0.041 0.061 0.018 1.389 1.913 0.367 0.380 0.811 -0.117

SE 0.003 0.007 0.000 -0.082 0.400 0.127 0.064 0.029 -0.094

LB 0.037 0.143 0.025 -0.362 0.015 0.015 0.384 0.524 -0.026

LM -1.081 -0.240 -0.165 -0.288 -0.601 -0.091 0.501 0.383 -1.124

LE 0.313 -0.844 -0.459 -0.032 0.096 0.024 0.004 -1.187 -0.148

Pro-Lys

HB HM HE SB SM SE LB LM LE

HB 2.228 0.764 0.219 0.222 -0.401 -0.120 0.757 0.381 0.155

HM 0.114 2.147 2.050 0.066 -0.189 0.007 0.286 0.391 -0.868

HE 0.135 0.217 1.641 0.010 0.018 0.001 0.025 0.131 0.131

SB 0.033 -0.217 0.009 2.454 2.066 0.162 0.420 0.543 0.574

SM 0.039 0.282 0.063 1.609 1.991 0.367 0.182 0.479 -0.466

SE 0.002 0.007 0.001 0.286 -0.002 -0.297 0.015 0.035 -0.137

LB -0.084 -0.483 -0.618 0.084 0.222 -0.129 1.637 0.640 -0.903

LM 0.468 -0.228 0.274 0.997 -0.377 -0.836 1.909 1.986 -0.561

LE 0.154 -2.332 -0.086 0.150 -0.330 -0.222 0.447 -0.745 -1.698

Pro-Glu

HB HM HE SB SM SE LB LM LE

HB 3.399 1.496 -0.197 0.164 0.109 0.003 0.248 0.804 0.070

HM 1.487 4.557 0.498 0.072 0.081 -0.021 0.424 0.787 -0.407

HE 0.306 0.099 -0.383 0.011 0.019 0.001 0.030 0.316 -0.058

SB 0.128 -0.043 -0.005 3.740 0.803 0.187 1.055 0.614 0.221

SM 0.040 0.061 0.040 0.823 1.711 0.024 0.103 -0.304 -0.003

SE 0.003 0.008 0.001 -0.190 0.322 0.148 0.020 0.005 0.022

LB 0.556 0.010 -0.114 0.120 -1.598 -0.063 1.925 0.762 0.330

LM -0.374 -0.622 -0.251 0.819 -0.143 -0.150 0.299 2.327 -0.134

LE 0.364 -1.321 -1.223 0.703 -0.050 0.042 0.150 -0.035 -1.160

Asn-asn

HB HM HE SB SM SE LB LM LE

HB 0.761 1.334 0.320 0.214 0.056 0.003 0.440 0.149 -0.080

HM -0.989 -0.837 0.493 -0.136 -0.165 -0.172 -0.690 -0.723

HE -0.454 0.015 0.083 0.001 -0.238 -0.173 -0.470

SB 1.700 1.719 0.089 0.677 0.739 0.231

SM 0.154 -0.348 -0.340 -0.107 -0.514

SE 0.055 0.260 -0.193 0.398

LB 0.469 0.024 0.033

LM -0.854 -0.861

LE -0.079

Asn-Thr

HB HM HE SB SM SE LB LM LE

HB 1.775 0.312 -0.054 -0.178 0.202 0.004 0.130 0.485 0.115

HM 1.519 -0.944 -1.629 0.080 -1.101 0.011 -0.071 0.548 -0.044

HE 0.000 0.732 -1.446 0.013 0.000 0.002 0.129 0.844 -0.211

SB 0.292 0.098 0.013 2.484 2.046 0.132 0.831 0.653 0.055

SM 0.053 0.069 0.019 1.636 -1.404 0.020 -0.184 0.765 -0.401

SE 0.004 0.008 0.002 -0.043 -2.647 0.035 0.018 0.055 0.036

LB 0.819 0.998 0.032 0.450 0.047 0.052 1.107 -0.265 0.644

LM 0.483 -0.340 -0.135 0.234 -0.532 0.354 0.492 -0.025 -1.591

LE 0.721 -0.765 -0.188 -0.055 -1.531 0.049 -0.203 -1.056 -1.206

Asn-ser

HB HM HE SB SM SE LB LM LE

HB 1.869 1.184 0.287 0.223 0.084 0.003 1.039 0.299 0.132

HM 1.698 0.409 -2.663 -0.874 -0.816 0.009 -0.164 -1.416 0.632

HE 0.428 -1.353 -4.029 0.018 -0.121 0.001 0.040 -0.164 0.164

SB -0.170 0.193 0.017 3.743 1.581 0.421 0.018 1.589 0.415

SM 0.062 -0.655 -0.534 2.475 -1.460 0.183 0.335 -1.297 -0.257

SE 0.004 0.009 0.001 0.342 -0.577 0.110 0.065 0.088 0.045

LB 0.378 0.138 0.041 -0.873 0.135 0.107 1.381 0.381 0.315

LM -0.226 -0.959 -0.328 -0.026 0.310 0.245 -1.062 0.983 -0.667

LE -0.559 -0.725 -0.057 0.016 -0.986 0.012 0.149 0.577 -0.424

Asn-arg

HB HM HE SB SM SE LB LM LE

HB 2.785 -0.053 -2.090 0.150 -0.371 0.003 0.584 0.232 -0.255

HM 2.116 0.457 -2.227 0.239 0.066 -0.421 0.658 -0.844 -1.165

HE 0.023 0.602 -1.710 0.008 0.019 0.001 0.035 -0.037 -0.061

SB 0.142 0.069 0.104 2.522 1.230 0.393 0.492 0.669 0.081

SM 0.042 -0.012 0.106 0.782 1.647 -1.333 0.213 -0.258 0.585

SE 0.003 -0.166 0.001 0.288 0.107 -1.312 0.013 0.315 0.032

LB 0.041 0.192 0.120 0.035 -0.344 0.080 1.917 -0.380 -1.126

LM 0.748 -1.554 -0.025 0.911 0.157 -0.015 1.138 -1.529 -0.808

LE -0.131 -0.303 -1.252 -0.201 -1.842 0.021 0.412 -1.558 0.401

Asn-gln

HB HM HE SB SM SE LB LM LE

HB 1.805 0.808 0.054 0.131 -0.130 0.002 0.404 0.564 -0.089

HM 1.458 0.522 -2.704 0.059 0.041 0.006 0.344 0.073 -0.810

HE -0.510 -1.600 2.008 0.011 -0.415 0.001 0.024 -0.047 0.220

SB 0.399 0.056 0.009 1.397 1.201 0.065 0.223 -0.164 0.129

SM -0.130 0.040 0.015 1.385 0.251 -0.259 0.217 -1.238 -0.702

SE 0.002 0.006 0.001 -0.766 -0.245 0.186 0.253 0.040 -0.186

LB 0.302 -0.219 0.142 0.320 0.312 0.077 0.254 0.250 0.077

LM -0.063 -2.023 -0.740 -0.663 -0.180 0.068 0.599 -0.932 -1.902

LE 0.088 -1.564 0.047 0.174 -0.291 0.026 0.063 0.596 0.188

Asn-asp

HB HM HE SB SM SE LB LM LE

HB 2.218 1.635 0.147 0.191 0.054 0.004 0.929 -0.079 -0.608

HM 0.955 1.384 -1.788 -0.135 0.119 0.009 0.191 0.214 -0.730

HE -0.217 -4.187 -0.310 0.012 0.022 0.000 0.045 0.197 -0.037

SB 0.394 0.077 0.010 2.844 1.811 0.378 0.206 1.106 -0.520

SM 0.052 0.080 0.023 1.639 2.595 -0.163 -0.175 -0.960 -0.753

SE 0.002 0.007 0.000 0.303 -0.979 -0.091 0.032 -0.005 -0.045

LB 0.682 0.665 0.050 0.849 -0.019 0.042 0.139 0.237 0.052

LM 0.154 -0.159 0.174 0.504 -2.046 0.052 -0.024 -1.479 -0.468

LE 0.101 -0.337 -0.563 -0.037 -0.589 0.045 -1.592 -0.248 -1.958

Asn-lys

HB HM HE SB SM SE LB LM LE

HB 2.406 1.442 0.732 0.159 0.048 0.003 0.628 -0.521 -0.173

HM 1.572 -0.418 -0.686 0.109 0.131 -0.057 0.418 0.145 -1.831

HE 0.179 -1.122 -1.634 0.493 0.021 0.001 0.129 0.281 -0.613

SB 0.085 0.207 0.000 2.876 1.817 1.117 0.158 -0.139 -0.402

SM 0.322 0.149 0.081 1.285 -0.090 0.148 0.228 0.500 -0.217

SE 0.003 0.009 0.001 0.278 -0.568 0.112 0.062 0.088 -0.370

LB 0.509 0.348 0.123 1.194 -0.915 -0.360 2.040 -0.083 -0.199

LM 0.778 -3.693 -1.623 0.652 0.994 -0.386 1.845 -0.030 -3.364

LE 0.213 0.272 -3.934 0.652 -0.247 0.335 0.325 0.235 -2.031

Asn-glu

HB HM HE SB SM SE LB LM LE

HB 2.502 0.031 0.131 0.085 0.045 0.003 1.150 0.924 0.144

HM 0.722 -1.429 -1.877 0.266 -0.845 0.009 0.297 0.848 0.253

HE 0.510 -0.643 -1.172 0.013 0.019 0.002 0.051 -0.083 0.117

SB 0.025 0.090 0.012 2.955 1.885 0.408 0.714 -0.234 -0.105

SM 0.109 -0.251 0.142 0.957 2.340 0.067 -0.185 -0.573 0.301

SE 0.003 0.008 0.002 0.346 0.148 0.227 0.015 0.104 -0.208

LB 0.138 -0.201 0.457 0.555 0.035 0.015 1.448 1.755 -0.624

LM -0.130 -0.975 -0.670 0.769 0.060 0.191 -0.155 -1.381 -1.350

LE 0.055 -0.792 0.424 0.267 -0.578 -0.007 0.241 0.099 -1.366

Thr-Thr

HB HM HE SB SM SE LB LM LE

HB 0.339 0.374 -1.508 0.086 -0.241 0.002 -0.172 1.095 -0.046

HM 1.457 -0.136 0.135 -0.435 0.009 0.461 -0.959 0.626

HE 0.871 -0.025 0.410 0.003 -0.171 0.250 -0.540

SB -0.023 0.660 0.045 0.459 0.425 -0.354

SM -2.268 -1.177 -0.207 -0.311 -0.521

SE -0.908 -0.105 -0.099 0.036

LB -0.784 -0.897 -0.116

LM -0.318 -0.328

LE 0.081

Thr-ser

HB HM HE SB SM SE LB LM LE

HB -0.662 0.816 -0.773 0.102 -0.106 0.004 0.284 0.824 0.283

HM 1.693 -1.470 0.667 0.091 0.120 0.009 -0.980 -2.133 0.355

HE -0.071 -0.704 0.299 0.110 0.138 0.001 0.042 0.318 0.031

SB 0.045 0.150 0.016 1.560 1.410 -0.122 0.567 0.424 -0.777

SM -0.358 -0.057 -0.084 0.381 0.090 0.453 -0.107 1.109 -0.772

SE 0.004 -0.002 0.001 0.532 -0.174 0.227 0.038 0.170 0.044

LB 0.151 -0.020 0.063 0.585 -0.034 0.054 1.844 -0.203 0.025

LM -0.272 -0.201 -0.023 -0.125 -0.798 0.334 -1.188 -1.517 -2.523

LE -0.054 0.488 0.663 -0.504 0.439 0.045 0.099 -2.082 -0.232

Thr-arg

HB HM HE SB SM SE LB LM LE

HB 3.083 -1.456 -0.148 0.311 0.138 0.002 0.690 -0.383 0.255

HM -0.451 -1.962 -1.650 0.067 0.218 -0.343 0.291 -0.467 0.395

HE 0.129 -1.279 3.060 0.009 0.018 0.002 0.028 0.237 0.399

SB 0.244 0.040 -0.239 1.425 -0.801 -0.676 0.534 -0.109 -0.505

SM 0.152 0.372 -0.122 1.694 0.204 -0.886 0.481 -0.125 0.459

SE 0.002 0.008 -0.132 0.224 -0.931 -0.443 0.015 0.148 0.029

LB 0.443 0.097 -0.141 -0.067 0.065 0.016 1.498 0.696 -0.303

LM 0.709 -0.600 -0.966 -0.949 -0.172 -0.083 0.354 -0.173 -1.502

LE 0.112 -2.530 -0.047 0.242 -0.207 0.029 0.084 0.782 0.148

Thr-gln

HB HM HE SB SM SE LB LM LE

HB 1.230 0.339 0.060 0.105 -0.482 0.002 0.297 0.159 0.357

HM 0.617 -3.231 -4.025 0.079 0.253 -0.048 -0.010 1.427 -0.136

HE 0.266 1.342 -1.503 0.009 0.000 0.002 0.029 -0.187 0.156

SB 0.137 0.013 0.008 1.756 -1.074 0.132 0.964 -0.272 -0.168

SM 0.131 -0.097 0.013 0.899 -1.149 -0.105 0.139 -0.033 -0.539

SE 0.002 0.007 0.002 0.018 -0.709 0.123 0.011 0.041 -0.203

LB 0.464 -0.251 -0.049 0.185 0.202 -0.116 1.374 1.487 -0.352

LM 0.628 -1.598 0.369 0.446 0.011 -0.242 0.653 0.778 -0.995

LE -0.094 -0.896 0.537 -0.312 0.114 0.053 0.107 -0.095 0.429

Thr-asp

HB HM HE SB SM SE LB LM LE

HB 3.617 1.658 0.686 0.132 0.176 0.004 0.175 0.123 -0.306

HM 2.471 -1.515 -0.564 -0.052 0.072 0.009 0.520 0.275 -1.277

HE 0.526 -0.598 -2.240 0.010 -0.019 0.001 0.032 -0.067 0.047

SB 0.351 0.150 0.011 2.377 0.141 0.311 0.426 0.127 0.083

SM -0.249 -0.152 -0.700 1.744 1.558 -0.324 0.435 -1.079 -0.045

SE 0.003 0.010 0.001 0.422 -0.080 0.011 0.016 -0.722 -0.284

LB 0.147 -0.624 0.032 0.538 -0.034 -0.368 0.552 -0.122 -0.265

LM -0.014 -1.167 -0.667 0.608 -0.371 0.056 -1.104 -2.998 -1.538

LE -0.076 -0.238 0.130 0.592 0.039 -0.039 -0.472 0.050 -0.523

Thr-lys

HB HM HE SB SM SE LB LM LE

HB 3.739 1.141 0.353 0.202 0.065 -0.029 0.561 0.430 -0.518

HM 1.793 1.750 -3.059 0.080 0.438 0.365 0.589 1.374 -3.159

HE -0.067 -0.857 -1.855 0.011 0.017 0.002 0.208 0.183 -0.004

SB 0.160 -0.897 -0.069 2.050 0.172 -1.378 1.205 0.650 -0.592

SM 0.076 0.168 -0.298 2.596 -0.378 -3.037 0.375 1.482 -1.451

SE 0.003 0.011 0.002 0.348 -1.585 -0.917 0.046 -0.081 -0.084

LB 0.500 -0.020 -0.174 0.693 -0.011 0.045 1.329 -1.485 -1.503

LM 1.035 -0.336 -0.945 0.891 -1.025 -0.073 1.877 1.249 -2.236

LE 0.135 -0.956 0.607 0.335 -0.098 0.079 0.296 1.425 -1.010

Thr-glu

HB HM HE SB SM SE LB LM LE

HB 2.378 -1.009 -0.653 0.160 0.052 0.004 0.748 0.723 -0.842

HM 0.650 -0.286 -3.554 0.133 -0.066 0.035 0.296 1.316 -0.083

HE 0.500 0.931 2.021 0.014 0.018 -0.107 0.032 0.496 0.319

SB -0.165 -0.184 -0.260 2.473 1.985 -0.583 0.439 0.222 0.565

SM 0.005 -0.053 0.019 0.630 -0.111 -1.128 0.994 -0.631 -1.162

SE 0.005 -0.009 0.003 0.317 0.223 -0.948 0.019 0.027 0.145

LB -0.324 -0.397 -0.015 0.121 0.260 0.069 1.677 1.066 0.086

LM 0.280 -3.865 0.055 0.832 0.110 0.181 1.296 0.668 -0.788

LE 0.010 -3.401 -0.137 0.141 0.202 -0.798 0.500 0.766 0.013

Ser-Ser

HB HM HE SB SM SE LB LM LE

HB 0.917 1.188 1.480 0.188 0.119 0.004 0.928 0.265 0.141

HM 0.507 1.165 -0.634 -0.199 0.012 1.216 0.469 -1.711

HE -1.304 0.024 -0.526 0.001 0.055 0.402 -0.489

SB 1.697 1.148 0.502 -0.060 0.450 0.126

SM 0.178 -0.284 0.358 0.235 0.493

SE -0.005 -0.020 0.112 0.057

LB 0.459 0.184 0.158

LM 0.665 -0.210

LE -0.116

Ser-arg

HB HM HE SB SM SE LB LM LE

HB 2.342 -0.795 -1.064 0.170 -0.525 -0.032 0.121 -1.469 0.147

HM 3.207 -0.426 -3.188 0.264 0.157 0.010 0.652 -0.520 0.178

HE 0.344 2.776 -3.092 0.012 0.027 0.001 0.192 -0.028 0.069

SB 0.193 -0.215 0.054 3.451 0.532 -0.546 0.786 -1.160 -0.512

SM 0.051 0.086 -0.574 0.839 1.714 -1.244 0.224 0.197 -0.582

SE 0.003 0.010 0.001 0.596 -0.243 0.049 0.019 0.225 -0.516

LB 0.513 -1.056 0.197 0.295 -0.773 -0.066 1.317 0.047 -1.136

LM 0.839 -1.346 -0.003 -0.341 -1.760 0.022 1.944 0.377 -1.351

LE 0.381 0.719 0.132 0.111 -1.075 -0.902 0.183 0.389 0.223

Ser-Gln

HB HM HE SB SM SE LB LM LE

HB 0.418 1.143 -0.042 0.132 0.043 0.003 0.605 0.840 0.121

HM 0.331 -2.160 -2.167 0.039 0.055 0.007 0.524 -0.391 0.461

HE 0.731 0.482 0.529 0.011 0.018 0.001 0.031 -0.196 0.112

SB 0.168 -0.221 0.061 1.376 -1.501 -0.033 0.477 0.262 0.582

SM 0.044 -0.084 0.018 1.746 -0.647 0.173 0.526 -0.732 0.087

SE 0.003 0.007 0.498 0.454 0.733 -0.479 0.032 0.049 -0.260

LB 0.350 0.046 0.031 0.098 -0.295 -0.265 1.162 -0.600 0.136

LM 0.467 -1.755 0.231 0.486 -0.948 0.049 0.574 -0.849 -0.017

LE 0.110 -0.478 -0.892 -0.106 -0.118 0.089 0.138 0.628 -2.462

Ser-Asp

HB HM HE SB SM SE LB LM LE

HB 3.835 1.218 -0.286 0.051 0.275 0.004 -0.105 -0.146 -0.070

HM 1.521 0.194 0.197 -0.398 0.203 0.010 0.248 -0.873 -0.537

HE 0.219 -1.564 0.199 0.014 0.033 0.001 -0.395 -0.326 0.266

SB 0.290 -0.165 0.013 2.443 0.797 -0.399 0.316 -0.752 -0.124

SM -0.038 0.104 -0.073 2.914 -0.107 0.142 0.278 0.457 -0.206

SE 0.004 0.012 0.143 0.426 0.645 0.093 0.021 0.160 0.207

LB 0.197 -0.193 0.079 0.827 0.688 0.021 0.066 -1.994 0.152

LM 0.490 -1.135 -1.082 0.844 0.492 -0.380 1.151 -4.888 0.379

LE 0.132 -0.123 -1.540 -0.188 0.323 0.188 0.139 -0.441 -0.311

Ser-lys

HB HM HE SB SM SE LB LM LE

HB 2.515 1.611 -2.486 0.311 0.147 -0.107 0.734 0.714 0.077

HM 2.955 0.576 -1.751 0.104 0.096 0.121 0.575 -1.440 -0.963

HE 0.262 2.380 0.891 0.017 0.033 0.001 0.043 0.297 -2.597

SB 0.036 0.100 0.016 2.946 1.895 -0.915 0.701 0.253 -1.347

SM 0.057 -0.308 -0.531 2.497 -0.803 -1.597 0.586 0.095 -0.897

SE 0.004 0.010 0.001 0.498 -0.900 0.175 0.020 0.280 -0.700

LB 0.890 0.538 -0.519 0.968 0.568 0.019 1.600 0.005 -1.216

LM 0.750 -1.236 -0.260 0.920 -1.128 0.220 2.083 0.006 -4.254

LE 0.112 -0.310 -1.401 -0.088 -0.234 -0.176 0.591 -1.874 0.498

Ser-Glu

HB HM HE SB SM SE LB LM LE

HB 2.498 -0.400 1.074 0.270 -0.249 0.004 0.914 1.425 0.006

HM 0.887 1.430 -4.044 0.092 0.091 -0.132 1.090 1.293 -0.268

HE 0.185 3.081 -7.655 0.019 0.030 -0.023 0.039 -0.111 -0.517

SB 0.385 0.184 0.017 2.977 2.294 -0.453 0.662 0.599 -0.624

SM 0.060 -0.231 0.050 -0.261 2.382 -0.960 0.428 0.433 -0.700

SE 0.005 0.012 0.001 0.219 0.118 0.093 0.024 0.081 0.179

LB 0.170 0.440 -0.133 0.349 -0.519 0.023 1.156 -1.818 -0.948

LM -0.202 -3.284 0.370 1.212 -0.303 0.318 1.526 -0.840 -1.894

LE -0.659 -3.334 1.607 0.222 -0.484 -0.247 0.128 0.191 -3.632

Arg-Arg

HB HM HE SB SM SE LB LM LE

HB 0.667 0.437 0.938 0.278 0.038 0.002 0.845 -0.139 0.077

HM 0.457 2.218 0.257 0.054 -0.243 0.241 0.083 0.695

HE -3.608 0.611 0.015 0.001 -0.146 0.155 -0.639

SB 1.486 1.046 0.282 0.166 0.665 0.126

SM 0.252 -1.292 0.199 -0.462 -1.639

SE -0.326 0.035 -0.178 0.031

LB 0.474 1.253 0.150

LM -0.017 -0.812

LE -0.426

Arg-Gln

HB HM HE SB SM SE LB LM LE

HB 2.161 0.625 -0.197 0.112 0.033 0.002 0.259 0.339 0.227

HM 1.613 1.547 -1.520 0.072 -0.133 0.006 0.137 0.649 -1.718

HE 0.072 0.102 -7.565 0.005 -0.011 0.001 0.058 -0.240 -1.351

SB 0.212 -0.064 0.005 2.341 1.561 0.206 0.219 0.377 -0.145

SM 0.001 -0.135 0.011 0.542 -1.175 0.688 0.112 -0.957 0.156

SE 0.002 -1.051 0.001 -0.031 0.070 0.024 0.010 0.067 -0.108

LB 0.593 0.421 0.022 0.355 0.159 0.010 0.969 0.715 -0.044

LM -0.328 1.425 0.304 0.300 0.086 0.287 0.377 -0.673 0.103

LE 0.119 0.280 0.087 0.155 -0.381 0.022 0.055 -0.304 -0.912

Arg-Asp

HB HM HE SB SM SE LB LM LE

HB 2.399 1.698 0.278 0.170 0.047 0.004 0.187 -0.010 0.011

HM 0.408 -3.451 2.602 -0.069 -0.054 0.009 0.446 -0.884 -0.838

HE -0.557 -10.334 -1.634 0.006 0.021 0.000 -0.060 -1.259 -0.410

SB 0.297 0.097 0.008 2.070 1.609 0.308 0.243 0.227 0.198

SM 0.156 0.053 0.211 1.018 -1.656 0.168 -0.113 -0.488 -0.271

SE 0.003 -0.421 0.001 -0.075 -1.925 0.155 -0.472 -0.362 -1.506

LB 0.503 0.338 0.028 0.759 0.493 0.014 0.577 1.403 0.458

LM 0.461 -0.452 0.183 -0.403 0.360 -0.349 -0.532 -2.950 -0.520

LE -0.398 -1.265 -0.505 0.079 0.209 0.033 0.032 -1.983 -1.393

Arg-Lys

HB HM HE SB SM SE LB LM LE

HB 2.714 0.424 -0.603 0.300 0.076 0.002 0.643 0.810 0.134

HM 2.738 -0.541 0.131 0.074 -0.006 -0.241 0.310 0.647 -2.351

HE 0.982 -1.632 -3.080 0.007 -0.902 0.001 0.025 -0.236 0.033

SB 0.139 0.070 0.010 2.345 1.020 0.671 0.722 0.825 0.305

SM 0.040 0.076 0.022 1.471 -1.608 -1.787 0.366 -0.126 -2.030

SE 0.002 0.008 0.001 0.499 -2.038 -0.468 0.015 0.075 -0.326

LB 0.599 0.189 0.025 0.633 -0.203 0.084 1.262 1.674 0.392

LM 0.603 0.154 -0.491 0.645 0.285 0.191 1.946 1.756 -1.976

LE 0.158 -0.585 0.461 0.499 -0.146 0.033 0.252 0.442 -1.415

Arg-Glu

HB HM HE SB SM SE LB LM LE

HB 2.736 2.521 0.139 0.183 0.047 0.003 0.441 0.603 0.175

HM -0.354 -4.978 1.109 0.155 0.204 0.010 -0.134 -0.055 -0.861

HE 0.431 -7.783 -1.374 0.008 0.018 0.002 -0.237 0.720 -0.332

SB 0.261 0.058 0.008 3.223 1.080 -0.256 0.531 0.305 -0.568

SM 0.042 0.179 0.017 0.384 -1.948 -0.496 0.357 -1.440 -0.140

SE 0.003 0.011 0.002 -0.244 -1.574 -0.628 0.182 -0.023 -0.380

LB 0.541 0.767 0.289 0.518 0.096 0.023 1.804 1.307 0.414

LM 0.731 -0.144 -0.490 0.061 -0.555 -0.070 -0.066 0.319 -0.367

LE -0.623 -0.826 0.314 -0.177 -0.263 -0.379 -1.351 -0.234 -0.367

Gln-gln

HB HM HE SB SM SE LB LM LE

HB 0.662 0.544 0.547 0.046 -0.060 0.002 -0.789 0.376 0.044

HM -0.989 -1.186 0.041 0.039 0.005 -0.022 0.229 -1.200

HE -0.878 0.006 -0.386 0.001 0.099 0.139 -2.033

SB 0.290 0.993 0.153 0.521 0.473 0.081

SM 0.078 -0.281 0.586 0.403 -0.582

SE 0.024 0.007 0.026 0.018

LB 0.063 0.482 0.614

LM 0.192 -0.051

LE 0.166

Gln-asp

HB HM HE SB SM SE LB LM LE

HB 2.084 3.212 0.782 -0.647 -0.063 0.002 0.298 0.263 0.165

HM 1.025 -1.587 -0.767 0.111 0.033 0.005 0.185 0.466 -0.891

HE 0.482 -3.087 0.293 0.008 0.013 0.001 0.024 -0.294 0.463

SB 0.140 0.056 -0.106 1.780 0.630 0.382 0.308 0.069 0.356

SM 0.038 0.043 0.013 0.199 -0.151 -0.675 -0.097 -0.052 0.218

SE 0.003 -0.198 0.001 0.191 -0.189 0.078 0.010 -0.209 -0.171

LB 0.321 0.252 0.087 0.210 0.198 0.011 0.803 1.507 0.274

LM 0.630 0.029 0.113 0.041 0.297 0.258 1.240 0.943 -0.542

LE -0.016 -0.466 -0.467 -0.338 -0.740 0.022 -0.610 -1.246 -0.341

Gln-lys

HB HM HE SB SM SE LB LM LE

HB 2.636 0.779 0.456 0.112 0.035 0.002 0.557 0.934 -0.057

HM 1.766 -0.260 -3.182 0.053 -0.312 0.006 0.360 0.215 -1.075

HE 0.466 0.602 -2.653 0.008 0.013 0.002 0.023 0.235 -1.360

SB 0.166 0.054 0.008 2.095 0.370 -0.268 0.385 0.391 0.136

SM 0.037 0.037 0.012 1.128 -4.058 -1.777 0.162 -0.623 -0.384

SE 0.002 0.006 0.002 0.386 -0.893 -1.303 0.126 0.083 0.064

LB 0.542 0.870 -0.129 0.392 0.188 0.086 1.332 0.774 0.014

LM 0.601 0.330 -0.322 0.472 0.412 -0.472 1.141 -0.926 -0.465

LE 0.105 1.125 -0.298 0.141 -0.277 0.050 0.189 0.920 -1.665

Gln-glu

HB HM HE SB SM SE LB LM LE

HB 1.247 1.133 -0.630 0.127 0.094 0.002 0.404 0.687 0.043

HM 2.370 0.841 -0.761 -0.040 -0.277 0.006 0.371 -0.681 0.582

HE 0.302 -2.782 -7.522 0.008 0.077 0.002 0.072 -0.010 0.194

SB 0.103 -0.054 0.008 1.447 0.486 0.018 0.662 0.804 0.112

SM 0.038 0.044 0.013 1.536 -2.082 0.003 0.327 -0.488 -0.346

SE 0.002 0.007 0.002 0.248 -0.075 -0.242 -0.006 0.040 -0.083

LB 0.436 0.659 0.279 0.370 -0.485 0.011 1.087 -0.145 -0.203

LM 0.440 -0.650 0.239 0.238 0.137 -0.104 0.836 1.351 -0.022

LE -0.095 -1.931 0.006 0.189 -0.295 -0.125 -0.269 -0.078 -0.036

Asp-Asp

HB HM HE SB SM SE LB LM LE

HB 1.269 1.031 0.538 0.199 0.057 0.003 0.676 0.335 0.367

HM -0.259 1.304 0.058 0.092 0.010 1.038 -0.448 0.601

HE -1.170 0.008 0.025 0.000 0.084 0.203 0.333

SB 2.015 1.944 0.282 0.035 0.085 0.022

SM -0.045 0.588 0.322 -0.029 0.176

SE 0.052 0.015 -0.228 0.036

LB 0.798 0.149 0.073

LM 1.381 0.110

LE -0.766

Asp-lys

HB HM HE SB SM SE LB LM LE

HB 3.494 2.120 -0.719 0.289 0.057 0.003 0.732 -0.344 -0.687

HM 2.399 -3.790 -4.735 0.229 -0.784 -0.352 0.666 -1.536 -0.555

HE 1.025 2.948 -2.104 0.010 0.025 0.001 0.083 0.211 -0.485

SB 0.388 0.057 0.012 2.943 2.582 0.412 0.826 0.472 0.176

SM 0.055 -0.061 0.052 1.383 1.754 0.027 0.294 -0.162 -1.035

SE 0.004 0.121 0.001 0.250 0.121 -0.479 0.029 -0.406 -0.085

LB 0.928 0.184 -0.756 0.711 -0.703 -0.030 1.707 0.795 -0.897

LM 0.274 -0.983 -1.362 0.249 -2.247 -3.100 1.922 -4.306 -8.441

LE 0.246 -0.468 -2.132 0.161 -0.539 -0.101 0.436 -0.338 -2.844

Asp-glu

HB HM HE SB SM SE LB LM LE

HB 2.390 2.193 -0.053 0.247 0.050 0.004 0.748 0.480 0.202

HM 3.351 -2.103 1.206 0.083 -0.403 0.009 0.945 1.026 -0.459

HE 0.117 1.922 -0.301 0.010 0.022 0.001 0.158 0.036 -0.262

SB 0.244 -0.058 0.010 3.764 2.382 0.260 -0.447 0.486 0.162

SM 0.083 -0.114 -0.144 2.424 1.312 0.306 0.455 1.147 0.163

SE 0.006 0.012 0.001 0.322 0.411 0.164 0.018 0.107 0.265

LB 0.025 0.074 -0.090 0.860 -0.318 0.044 1.575 0.870 0.267

LM 0.451 0.458 0.369 0.424 0.456 -0.810 2.235 2.006 -0.961

LE 0.249 -0.144 -0.920 0.116 0.406 -0.037 0.509 -0.001 -1.688

Lys-lys

HB HM HE SB SM SE LB LM LE

HB 1.925 4.534 -0.938 0.203 0.050 0.003 0.764 1.067 -0.081

HM -0.394 -1.523 0.102 0.121 0.013 0.633 0.873 -0.815

HE 1.208 0.178 -0.279 0.002 0.186 0.575 -2.561

SB 1.569 2.625 0.625 0.628 0.979 0.123

SM -0.917 -1.911 0.947 -0.173 -2.034

SE 0.032 0.042 0.275 -0.084

LB 0.797 2.086 0.526

LM 0.797 -1.012

LE -2.546

Lys-glu

HB HM HE SB SM SE LB LM LE

HB 4.439 3.037 0.392 -0.124 0.053 0.004 0.925 0.539 -0.853

HM 2.309 -3.158 -4.206 -0.041 0.053 0.000 0.325 0.225 -1.641

HE 0.297 -6.141 -1.626 0.013 0.070 -0.021 0.059 -0.321 -2.769

SB 0.193 0.235 0.013 3.394 2.560 0.568 0.726 1.085 0.032

SM -0.038 0.045 -0.091 1.796 -7.262 -1.194 0.463 0.183 -1.981

SE 0.003 -0.413 0.003 0.163 -3.182 -1.203 0.019 0.053 -0.481

LB 0.859 0.789 0.171 0.979 0.431 0.039 1.555 1.875 0.804

LM 0.817 0.673 -0.911 0.703 -0.298 -0.061 1.830 0.301 -2.850

LE -0.333 -2.227 -1.295 0.458 -2.082 0.026 0.434 -1.251 -2.852

Glu-glu

HB HM HE SB SM SE LB LM LE

HB 1.156 1.258 0.224 0.262 0.075 0.006 0.963 0.757 -1.101

HM -1.361 -4.547 0.095 -1.343 0.038 0.857 1.347 -1.563

HE 0.216 0.016 0.055 0.003 0.253 -0.029 0.066

SB 2.128 2.022 0.751 0.970 0.448 -0.743

SM 0.780 -0.250 0.695 0.064 -1.521

SE -0.370 0.026 0.065 -0.235

LB 1.145 1.382 -1.828

LM 0.613 -1.383

LE -0.782

The present invention configured as described above is useful for analyzing the structural stability of a protein to determine whether the structure of a given protein is a natural structure by introducing an environmental score function considering environmental variables and by neural network learning theory and protein threading method. It works.

Claims (15)

A plurality of training protein groups representing a natural structure extracted from protein data in which amino acid sequence structure and tertiary structure by X-ray crystallography are known; In the training protein group, A protein of length N _A and _B protein of length N _B (N _A ≤N _B ), the sequence of protein _A starting from the first amino acid of protein B without a gap and ending N _A times To produce one decoy structure of protein A, and to match the sequence of protein _A to the structure starting from the second amino acid of protein B and ending N _A + 1th, the other decoy structure of protein A. And repeat the method of generating another decoy structure of protein A by matching the sequence of protein _A to the structure starting from the third amino acid of protein B and ending with N _A + 2nd. A training decoy structural protein group formed by forming a decoy structure of the protein for each of the naturally occurring proteins involved; Using a score function that includes all kinds of amino acids and local environments and quantitatively represents the energy level when the sequence s is in the structure Γ, it is calculated to satisfy the following equation 9 which expresses the difference between the decoy structure and the natural structure. Score parameters; A new protein / new protein group not belonging to the training protein group; The new decoy structure protein group formed for the training protein group that is equal to or longer than the length of the new protein / new protein group by the same method obtained from the training decoy structure protein group using the training protein group; Ramachandran characterized by determining whether the structure of the new protein is a natural structure by determining whether the new protein / new protein group satisfies Equation 9 using the score parameter obtained above. Method of structural stability analysis of protein by thermodynamic energy function including bond between each and amino acid. Wherein n (i, m) and n (i, m) ^D are the number of amino acids in the m local environment where i-type amino acids in the natural structure and the decoy structure, respectively, are in 9 environments and the Φ-Ψ matrix, ε (i, m) is the score parameter associated with this amino acid, and n (i, j; k, l) and n (i, j; k, l) ^D are pairwise contacts in the natural and decoy structures, respectively. Is the number of amino acids in the local environment with k, l amino acids of the form i, j linked together, ε (i, j; k, l) is the score parameter associated with these amino acids, and p is the ramachandran Number of rows / columns when representing angle (Φ, Ψ) as square matrix. A plurality of training protein groups representing a natural structure extracted from protein data in which amino acid sequence structure and tertiary structure by X-ray crystallography are known; In the training protein group, A protein of length N _A and _B protein of length N _B (N _A ≤N _B ), the sequence of protein _A starting from the first amino acid of protein B without a gap and ending N _A times To produce one decoy structure of protein A, and to match the sequence of protein _A to the structure starting from the second amino acid of protein B and ending N _A + 1th, the other decoy structure of protein A. And repeat the method of generating another decoy structure of protein A by matching the sequence of protein _A to the structure starting from the third amino acid of protein B and ending with N _A + 2nd. A training decoy structural protein group formed by forming a decoy structure of the protein for each of the naturally occurring proteins involved; Using a score function that includes all kinds of amino acids and local environment and quantitatively represents the energy level when sequence s is in structure Γ, it is calculated to satisfy the following equation 10 which expresses the difference between decoy structure and natural structure. Score parameters; A new protein / new protein group not belonging to the training protein group; The new decoy structure protein group formed for the training protein group that is equal to or longer than the length of the new protein / new protein group by the same method obtained from the training decoy structure protein group using the training protein group; Ramachandran characterized by determining whether the structure of the new protein is a natural structure by determining whether the new protein / new protein group satisfies Equation 10 using the score parameter obtained above. Method of structural stability analysis of protein by thermodynamic energy function including bond between each and amino acid. Wherein n (i, m) and n (i, m) ^D are the number of amino acids in the m local environment where i-type amino acids in the natural structure and the decoy structure, respectively, are in 9 environments and the Φ-Ψ matrix, ε (i, m) is the score parameter associated with this amino acid, and p is the number of rows / columns when representing the lamachandran angle (Φ, Ψ) in a square matrix. The method of claim 1 or 2, wherein the training protein group is a protein having a homology of less than 30%. According to claim 1 or 2, wherein the novel protein / new protein group is a structural stability analysis of the protein by thermodynamic energy function including the binding between amino acids and amino acids, characterized in that the protein having a homology of less than 90% Way. The method according to claim 3, wherein the training protein group is (1) X-ray crystallography of the protein group obtained from PDB and WhatIF, (2) a protein having a structure not containing non-standard amino acids, and (3) A method of analyzing the structural stability of a protein by thermodynamic energy function including a bond between an angle and an amino acid, characterized by a protein having a structure without a broken chain and (4) a protein having no mutated structure. 3. The structural stability of a protein according to claim 1 or 2, wherein the equation is satisfied for all the training decoy structures belonging to the training decoy structural protein group. Analytical Method. 7. The method of claim 6, wherein the score parameter is a value that satisfies all of the equations for the training decoy structure. . The method of claim 1 or 2, wherein the score parameter is calculated by repeating neural network learning and protein threading methods. A solution according to claim 1 or 2, wherein the solution satisfying the above equation is: (1) the score of the natural structure of a given protein is necessarily lower than the average score of a random sequence having a constant amino acid composition ratio over its own natural structure. And (2) the score of the natural structure of a given protein is obtained by calculating a score inequality that satisfies the requirement that its own sequence always have a lower value than the average score of the decoy structure. Chandran is a method of structural stability analysis of proteins by thermodynamic energy function including the bond between angle and amino acid. The method of claim 9, wherein after obtaining a score parameter that satisfies the score inequality, a threading test is performed to verify whether the equation is satisfied for all decoy structures belonging to the training decoy structure protein group using the score parameter. Ramachand is a structural stability analysis method of the protein by thermodynamic energy function including the bond between angle and amino acid. 11. The method of claim 10, after the threading test, the decoy structure that does not satisfy the equation is updated by adding a correction value to the score parameter, and by forming a first failure decoy structure inequality using the updated score parameter as an independent variable A method for analyzing the structural stability of a protein by thermodynamic energy function including a bond between an angle and an amino acid, wherein a score parameter satisfying the inequality coincided with the score inequality is calculated. 12. The threading test of claim 11, wherein all of the decoy structures belonging to the training decoy structure protein group are satisfied using the score parameter, and a threading test is performed to determine whether the decoy structure does not satisfy the equation. For example, a second failure decoy structure inequality using an updated score parameter as an independent variable is updated by adding a correction value to the score parameter, and the score parameter that satisfies the inequality that is consistent with the score inequality and first failure inequality is calculated. A method for analyzing the structural stability of proteins by thermodynamic energy functions including the binding between amino acids and amino acids, characterized in that a score parameter is calculated to satisfy the equation for all decoy structures belonging to the training decoy structure by repeating a series of processes. . The method according to claim 1 or 2, wherein the local environment includes three secondary structures, α-helix, β-strand and loop structure for one amino acid, and according to the degree of hydrophobicity (or solvation), By dividing the values of the exposed ratio by less than 10%, 10-50%, and more than 50%, these values are classified into three classes: buried, medium, and exposed. Φ, Ψ) divided by 40 ° into 9 equal parts on the x and y axes, respectively, resulting in the formation of a total of 81 Ramachandra environmental covariates, the local environment. Method for analyzing the structural stability of the protein by. The method of claim 1, wherein 30,870 score parameters are calculated in consideration of the local environment. The method of claim 2, wherein 14,580 score parameters are calculated in consideration of the local environment.