KR200371990Y1 - Poultice with type of the monolithic construction - Google Patents

Abstract

The present invention relates to an integrated poultice agent, which generally comprises a gel-like solid layer containing a drug and a contact cloth for adhesion of the skin, and a solid gel layer containing a drug when adhered to the skin is attached to the contact cloth. After providing a method for attaching to the skin, this is to provide convenience because there is a hassle when attaching the skin. In addition, the poultice has adhesive surfaces on the top, bottom, left and right, so it is not easily detachable when attached to the skin, and it is breathable, so it is a new integrated poultice manufacturing method with little irritation of the skin, which reduces the manufacturing cost and shortens the manufacturing process. In the product, it is possible to prevent desorption of the end part, to maintain elasticity and stable adhesion state corresponding to joint movement, and to easily desorb without damaging the skin during desorption, and to absorb the drug by full adhesion of the drug layer by the slope adhesion method. It is possible to produce a product that can deliver the maximum effect on the affected area, such as increase and prevent external loss of the drug.

Description

Poultice with type of the monolithic construction

The present invention relates to an integral poultice agent, and more particularly, to an integrated poultice agent in which a solidified gel phase containing a drug is present in the middle of the poultice agent, and an adhesive is present at the edge portion, thereby providing convenience and ease of manufacture. do. In general, a poultice agent (paste, Fig. 1) is composed of a film for fixing and protecting the drug-containing solidified gel layer 20 to the support 21 as a layer containing the drug (Fig. 1b) (22 ), And also called an adhesive cloth (FIG. 1, a) is produced by casting the pressure-sensitive adhesive (11) on the release paper (12, 13) and then transferred to the nonwoven fabric (10). In addition, since the drug-containing solid adhesive has a weak adhesive force, the adhesive cloth for the adhesion of the skin is contained separately, and a general use method is to remove the release film for protecting the drug layer on the support on which the drug-containing solidified gel layer is treated. , Bottom, left, and right at regular intervals to adhere to the adhesive cloth and then adhere it to the skin by attaching it to the skin. However, if the drug-containing solidified gel layer is adhered to the adhesive cloth incorrectly, the adhesion of the skin may not be good, and this poultice may be wasted. Also, the adhesive may not detach from the skin due to the lack of adhesive force when attached to the skin. have. In order to solve this problem and increase the patient's compliance with the poultice agent, Korean Patent Publication No. 2000-0060794 generally consists of only non-woven fabric having a different elasticity and a very low stretch ratio, and instead of thin film having a perforation line. Therefore, when a user wants to apply a poultice agent, the adhesive agent without a cloth is improved by pulling to both sides to peel only the film from the nonwoven fabric and attaching it to the skin. However, it has a shape that is detached from the skin by the restoring force of the nonwoven fabric when the elastic nonwoven fabric is attached to the skin, and also because the poultice agent must be attached to the skin, it must be attached for a long time because it has a certain adhesive force. It has nothing to do with it. Korean Patent Laid-Open Publication No. 2003-0040615 discloses a first method of manufacturing a poultice agent that can be easily detached without pain or skin damage even when it is maintained in a stable adhesion state, and a method of preparing the poultice agent except for a predetermined width at both ends of the substrate. A first adhesive coating step of applying the pressure-sensitive adhesive to a predetermined thickness; It provides a method for producing a foaming agent comprising the first pressure-sensitive adhesive comprising a second adhesive coating step of applying a second pressure-sensitive adhesive to both ends of the uncoated base material to a predetermined thickness. However, the present invention does not provide a poultice with a pressure-sensitive adhesive is treated only on the left and right, and the adhesive is treated on the edges of the upper, lower, left, and right sides so that the skin is more easily attached and maintains adhesion even when attached for a long time. In addition, also in the manufacturing method is different from the invention of the present application, Korean Patent Laid-Open Publication No. 2003-0040615 is a method of transferring a solid gel-like layer containing a drug to a nonwoven fabric and then transferring the adhesive to the adhesive-treated adhesive cloth, which is different from the conventional poultice agent. However, in the present application, since a method of manufacturing a single body directly without processing a solidified gel phase containing a drug on an adhesive fabric using a newly manufactured gear roller, the production is easy and productivity is low and manufacturing cost is low.

The conventional poultices using a solidified gel layer containing the drug and the drug is a formulation that is excellent in the therapeutic effect and the poulticeous effect of the drug, as well as the action of separating the paper material from the adhesive, the adhesive is attached to the adhesive There are processes that make it difficult to use again without attention, such as movement, or difficult to achieve the therapeutic effect of the poultice. In addition, there is a limitation in the use space because the treatment operation must be performed on a pedestal during use.

Figure 1a is a perspective view showing the structure of the contact cloth used in the conventional slope adhesion method,

Figure 1b is a perspective view showing the structure of the solidified gel-like layer containing the drug used in the conventional slope adhesion method,

Figure 1c is a plan view showing a method of using a solidified gel-like layer containing a conventional adhesive cloth and drug of the slope adhesion method,

2a and 2b is a plan view and a cross-sectional view showing the structure of the integral poultice agent according to the present invention,

3 is a process chart in which the contact cloth and the poultice agent of the method for producing a poultice agent according to the present invention.

※ Explanation of code about main part of drawing ※

1: nonwoven fabric, 2: adhesive layer

1 + 2: adhesive cloth 3: open tape

4: drug containing layer 5: release film

10: nonwoven fabric 11: adhesive

12: Release paper I 13: Release paper II

20: nonwoven fabric 21: solidified gel phase containing drug

22: release film 30: specially produced gear roller

31: nonwoven fabric to be conveyed 32: release film

33: drug-containing gel 34: knife caster

35: adhesive 36: die cutting machine

In order to provide the convenience of use of the present invention and to prevent the defoamer from detaching from the skin as much as possible, and to solve the problems of the above-mentioned defoamer provided in general, a solidified gel containing a drug is provided. It is a form in which the adhesive-treated adhesive cloth is present on all the edges of the upper layer, the upper, lower, left and right sides together, and provides a method of removing only the release liner to protect the drug when attached to the skin.

To describe the present invention in more detail requires the description of the roller having a concave groove of a certain size at a certain interval of the gear type. In other words, the first roller with a certain size of recessed grooves is a heatable roller that heats the release film and vacuums the inside of the groove to form the release film into a groove shape, and the release film of the second roller is formed into the groove of the second roller. Put the medicine on the knife coater on top. The depth of the groove of the roller can be freely adjusted accordingly to adjust the thickness of the drug layer to adjust the content of the drug, the width of the drug layer can be adjusted according to the size of the tooth. In addition, the adhesive on the other side is the roller with the central part coming out embossed and the grooves on the top, bottom, left and right as opposed to the roller applying the drug layer. It is possible to use a nozzle type hot melt applicator in a release liner without a transfer method or with a roller. The nozzle type is the thickness of the adhesive applied according to the discharge amount of the adhesive in such a way that a certain area is continuously coated with the adhesive by the on and off of the nozzle, and a certain area is applied with the adhesive at a predetermined interval by the nozzle on or off. Can be adjusted. More specifically, it is shown in FIG.

The components used in the poultice are polyacrylic acid salts, acrylate aqueous solution, polyacrylic acid copolymer (trade name-carbomer), methoxy ethylene maleic anhydride copolymer (PVM and VM Copolymer), gelatin, polyvinyl alcohol Inorganic fillers such as kaolin, titanium oxide, zinc oxide, iron oxide, talc, and adsorption and coloring agents may be added to a single or mixture of polyvinylpyrrolidone, natural or synthetic latex, and inorganic salts of modified cellulose. , Glycerin, D-sorbitol and purified water can be added as a solvent and used in the form of gel or liquid.

According to the purpose of use, the integrated poultice agent of the present invention can be applied by adding one or more drugs selected from anti-inflammatory analgesics, warming agents, cooling agents, vasodilators, blood circulation agents, muscle relaxants, steroids and antibacterial agents, local anesthetics, and herbal medicines. Can be.

Next, the present invention will be described in more detail as examples.

Example

Hereinafter, the manufacturing method and the poultice agent according to the present invention will be described in detail as shown in FIGS. 2A, 2B, and 3.

The poultice agent according to the present invention is composed of an adhesive cloth (1 + 2), an adhesive layer (2), a drug layer (4), a protective film (5) and an open tape (3) as shown in Figure 2a, 2b.

The adhesive cloth (1 + 2) has a slight supporting force so that the adhesive layer (2), the drug layer (4) is applied well, and the drug does not leak to the rear side, as long as it is used in a general poultice agent and a poultice agent is In order to maintain a stable adhesion state, a relatively thin layer is preferable.

The adhesive layer (2) is applied to the remaining portion except the rectangular shape of the middle and the adhesive force is not excessive and is applied to a constant thickness separately from the coating process of the drug layer (4) and then combined with the drug layer (4) Slope adhesive type poultice is formed. The pressure-sensitive adhesive layer is a rubber-based adhesive, preferably a diene-based polymer, in particular, a styrene-isomerene-styrene block copolymer mixed with a tackifier, a softener, an antioxidant, and other additives. Spraying) method.

The drug layer 4 is the basis of the poultice agent, and includes a drug having a pharmacological action, and is applied to a middle rectangular portion in which the adhesive layer 2 is not applied, separately from the application of the adhesive layer 2. It is then combined with the adhesive layer. Unlike the drug layer of the existing poultice, even if the adhesive strength and adhesion strength is weak or little, the drug layer can be completely adhered to the affected area.

The protective film (5) is molded and processed to serve as a support for the coated paper of the drug and to protect the drug-containing layer, there is a slight adhesive force with the adhesive layer (2), drug layer (4) and easy to remove if necessary. As long as it is easy to separate, it can be any paper and plastic films, such as CPP and PET, or a suitable release agent treatment to this.

The open tape (3) is used to easily remove the protective film (5) when attached to the affected part, if the adhesive layer (2) can be easily detached from the paper, plastic film, or if the appropriate release agent treatment Either way is possible. Although shown in only one direction in FIG. 2, the protective film 5 may be manufactured to be positioned at both edges or four corners for easier removal of the protective film 5.

In order to produce such an integral poultice, the inventors have to devise a special mechanical device. The following description is an apparatus (FIG. 3) for producing an integral poultice agent. In applying the adhesive 35 to the nonwoven fabric 31, there is a gear-shaped roller 30, and a method of transferring the adhesive only to the edge except the middle where the drug-containing layer enters is devised. In addition, the opposite side of the roller 30 of the gear wheel is first the mold release film is molded according to the mold shape of the tooth film is brought to a certain temperature in accordance with the thickness of the drug, and the drug is put into the molded film mold with a knife coater. A special roller was prepared in which the drug-containing layer was designed to be coated on a part of a certain size cast on a release film and an intermediate part on which an adhesive was not transferred to a nonwoven fabric. The integrated poultice agent thus produced shows a form in which the drug layer is applied in the middle and the adhesive layer is applied to the edges of the slopes.

In addition, the new manufacturing method of the integrated poultice agent in the present invention does not include all the parts of the present invention to explain the overall process step by step. The first step: adhesive layer coating step, drug layer coating step, the second step: adhesive layer and drug layer lamination step (open tape insertion step), the third step: cutting, the fourth step: packaging step will be described in detail.

(First step)

First, in the adhesive layer applying step, the adhesive transferred from the adhesive storage tank first passes through a roller having a mold or is sprayed through a nozzle at a predetermined interval and shape by a hot melt manufacturing method (high temperature melting spray method), and has a square frame shape or a square shape. Apply in the shape of the shape. At this time, the adhesive cloth or the protective film wound on the roller passes through the pressure-sensitive adhesive applying roller so that the pressure-sensitive adhesive layer can be applied through the transfer device. The adhesive layer applied in this way is combined with the applied drug layer, the open tape is formed as shown in FIG. .

The drug layer application step is applied at the same time because it must be combined with the adhesive layer. In order to meet these conditions, the process should be designed to be as short and interlocked as possible. The drug layer is applied directly to the inside of the adhesive layer forming a rectangular frame shape or a square shape at a constant thickness. The drug layer is similar to the method of applying the adhesive layer. The drug is filled into the mold by passing through the layer applying roller, which is then scraped with a knife to form the drug into the mold and transferred to the adhesive cloth transferred through the roller on which the adhesive cloth is wound.

The adhesive layer and the drug layer may be selectively determined to be applied to the adhesion cloth or the protective film, respectively, according to physical properties. However, since the drug layer has a higher viscosity than the adhesive layer, it is preferable to apply the drug layer to the adhesion cloth as much as possible. The drug layer and the adhesive layer applied in this way are transferred to the adhesive layer and the drug layer lamination step (open tape insertion step).

(Second step)

In the adhesive layer and the drug layer lamination step (open tape insertion step), the adhesive layer and the drug layer are laminated to each other, and an open tape is inserted to form an integral poultice agent. The open tape wound on the roller is conveyed through the conveying device to be bonded to the middle of the surface where the adhesive layer and the drug layer are applied. The semifinished product applied in this way is passed through the cutting step to the packaging step.

(Third step)

In the cutting step, the adhesive layer and the drug layer are laminated and cut by the die cutter in the form of FIG. 2A. This is cut to a certain standard by the existing cutting method and transferred to the packaging stage by a conveyor or a suitable transfer device.

(Fourth step)

The packaging step is a process in which the cut semi-finished product is packaged in airtight silver foil packaging. The conventional adhesive method for foaming the conventional slope adhesive has a complicated process of packaging the adhesive cloth separately from the packaging process, while the packaging method of the present invention omits the adhesive cloth packaging process. As a result, cost, space, and manufacturing time can be shortened.

Specific examples in the present invention are prepared by the composition of the examples. But this is not all of the invention.

Example 1 Composition of Poultice Agents Containing Anti-inflammatory Analgesics

Furtherance Parts by weight Ketoprofen Part 3.0 Polyacrylate Part 6.0 gelatin Part 4.5 Methoxyethylene Maleic Anhydride Copolymer Part 3.0 Polyvinylpyrrolidone 1.0 part Inorganic salts of denatured cellulose Part 2.5 kaoline Part 3.0 Titanium oxide 1.0 part glycerin Part 16.0 D-sorbitol Part 10.0 Sorbitan sesquioleate Part 2.0 Purified water Part 48.0

Example 2 Composition of Poultice Agent Containing Cooling Agent

Furtherance Parts by weight Hwangbaekyeonyeonx Part 1.2 Natural nature 0.4 part L-menthol Part 1.3 DL-Kampa 0.7 part Salicylic acid glycol 1.5 Tocopherol Acetate 0.5 part Polyacrylate Part 6.0 Polyacrylic Acid Copolymer Part 8.4 gelatin Part 2.5 Polyvinyl alcohol Part 2.0 Inorganic salts of denatured cellulose Part 2.5 kaoline Part 4.0 glycerin Part 16.0 Purified water Part 52.0

Example 3 Composition of Poultice Agent Containing Warmer

Furtherance Parts by weight Nonyl acid vanylamide 0.005parts L-menthol Part 2.0 Salicylic acid glycol 1.5 Tocopherol Acetate 0.5 part Polyacrylate Part 6.0 Polyacrylic Acid Copolymer Part 10.0 gelatin Part 2.5 Polyvinyl alcohol Part 2.0 Inorganic salts of denatured cellulose Part 2.5 kaoline Part 4.0 glycerin Part 16.0 Purified water Part 52.0

Example 4 Composition of Poultice Containing Anesthetic

Furtherance Parts by weight Lidocaine Part 5.0 Polyacrylate Part 4.0 Acrylate solution Part 2.0 gelatin Part 4.5 Propylene glycol Part 3.0 Inorganic salts of denatured cellulose Part 2.5 kaoline Part 4.0 glycerin Part 26.0 Purified water Part 49.0

Example 5 Composition of anti-inflammatory analgesic poultice containing herbal ingredient

Furtherance Parts by weight Yellow White Extract Part 5.0 Gardenia Extract Part 5.0 Polyacrylate Part 4.0 Acrylate solution Part 2.0 gelatin Part 4.5 Propylene glycol Part 3.0 Inorganic salts of denatured cellulose Part 2.5 kaoline Part 4.0 glycerin Part 26.0 Purified water Part 43.0

The new integrated poultice agent of the present invention is easier to manufacture and more productive than the existing manufacturing method, and can contribute to a reduction in manufacturing cost. It is to provide a stable and convenient poultice agent that can maintain a stable adhesion state, prevent drug loss, easy adhesion during use, and minimize the pain or skin damage caused during removal.

Claims (6)

An integral type characterized in that the drug-containing layer (4) is applied and adhered to the center of the contact cloth (1 + 2), the adhesive layer (2) is transferred only to the edge of the drug-containing layer, and the protective film layer (5) thereon. Poultice. (delete) According to claim 1, wherein the drug-containing layer (4) and the pressure-sensitive adhesive layer (2) on the adhesive cloth (1 + 2) of about 5 to 30 mm at the upper, lower, left, right end portions of the adhesive cloth (1 + 2) Integral poultice, characterized in that it comprises a pressure-sensitive adhesive easy to adhere to the skin and the drug-containing layer (4) in the central portion. The method of claim 1, wherein the pressure-sensitive adhesive layer (2) is a hot pack type adhesive, characterized in that the adhesive selected from the adhesive pressure-sensitive adhesive, acrylic adhesive, natural rubber adhesive, synthetic rubber-based adhesive. The component of the drug-containing layer (4) according to claim 1, wherein the components of the drug-containing layer (4) are made of polyacrylate, an aqueous solution of an acrylate, a polyacrylic acid copolymer (trade name-carbomer), a methoxy ethylene maleic anhydride copolymer (PVM and VM Copolymer), gelatin, Inorganic fillers such as kaolin, titanium oxide, zinc oxide, iron oxide, talc, adsorption and the like on one or more mixtures selected from polyvinyl alcohol, polyvinylpyrrolidone, natural or synthetic latex, and inorganic salts of modified cellulose. An integrated poultice agent characterized in that the gel or liquid form by adding at least one component selected from colorants, and at least one solvent selected from glycerin, D-sorbitol and purified water. The drug contained in the drug-containing layer (4) is a ketoprofen, felbinac, indomethacin, pyroxicam, diclofenac, a thermosensitive agent selected from nonyl acid vanylamide, capsaicin, and capsicum tink. Anti-inflammatory pain on paper; At least one cold sensitizer selected from elmenthol, menthol derivatives and diecampa; Vasodilators; Blood circulation agents; Muscle relaxant; Steroids; Antibacterial agents; Local anesthetics include lidocaine; And a herbal medicine comprising a drug selected from one or more herbal medicines selected from yellowish white, gardenia, sancho and arnica.