KR20030079231A - Topical cosmetic products which have anti-acne efficacy for the patients with acne and their manufacturing methods. - Google Patents

Abstract

PURPOSE: Provided are a topical cosmetic composition having anti-acne efficacy and manufacturing method thereof. The composition prevents skin pores from being clogged and inhibits the growth of bacteria causing acne. CONSTITUTION: A topical cosmetic composition having anti acne efficacy is characterized by comprising 10-50 wt.% of ethanol, 0.01-0.5 wt.% of sphingolipid, 0.01-5 wt.% of fermentation metabolite of Candida bombicola, 0.01-1.0 wt.% of salicylic acid, 0.01-5 wt.% of lactic acid and 1-10 wt.% of isopropyl alcohol.

Description

Topical cosmetic products which have anti-acne efficacy for the patients with acne and their manufacturing methods.

The present invention relates to a cosmetic composition having a healing effect on skin acne caused by sebum and microorganisms in skin lesions, and a method of manufacturing the same, wherein the anti-acne effect of the composition is primarily a growth inhibition mechanism of acne-causing strains without skin side effects. Secondly, by exfoliating the skin and removing sebaceous glands, it prevents inflammation in the pores and ultimately gives an acne skin improvement effect.

In general, acne develops not only on the face but also on the skin (back, chest) of various parts. The causes of the occurrence include body hormones, excessive secretion of sebum, clogging of hair follicles by the stratum corneum, and the reproduction of harmful microorganisms. Various treatments are being performed on acne caused by a combination of these various factors. Typical treatments include applying antibiotics such as erythromycin and clindamycin to the skin, applying benzoyl peroxide and vitamin A derivatives to the skin, taking oral antibiotics, and using lasers. Are done. However, these therapies may cause problems such as skin side effects with long-term use as drugs and physical methods of treatment. In particular, treatment with antibiotics can cause problems with resistance to antibiotics. Acne treatment is not possible at a moment, but requires a steady and continuous management, but the above methods can be said to put a lot of pressure on acne patients. On the other hand, the cosmetic composition is a two-step system that combines an acne-producing strain and a substance that is effective in removing pore blockage by skin exfoliation, and uses it in an excipient to reduce the burden on the skin and to treat anti-acne. It can be said that there is a big advantage to prevent acne recurrence by continually managing acne.

Therefore, the present invention combines the components reported to have an antimicrobial effect against acne strains and the components effective to remove the skin exfoliation in order to solve the problems of use, skin side effects and at the same time to maximize the anti-acne effect. As a result of applying it to acne skin, it was found that it is very effective compared to other known therapies, thus completing the present invention. Therefore, the present invention is a cosmetic composition that is not a pharmaceutical composition can be used universally for a long time without limitation of age and to provide a cosmetic composition that prevents the treatment and recurrence of acne by continuously managing the skin of people suffering from acne There is this.

1 is a photograph comparing the antimicrobial activity of the cosmetic composition prepared according to the present invention with respect to other compositions for Propionibacterium acnes . E is erythromycin, C is clindamycin, B is a cosmetic composition according to the present invention, I is a mixture of isopropyl alcohol and ethanol.

The present invention relates to a cosmetic composition containing an effective ingredient for acne skin, metabolites by glucose / methyl rapeseedate fermentation of sphingolipid, salicylic acid and Candida bombicola strains in excipients of ethanol and isopyrophyll alcohol, and lactic acid as an AHA component. It is characterized by a cosmetic composition for improving acne that is dissolved and dispersed.

This composition comprises 10-50% by weight of ethanol, 0.01-0.5 % by weight of sphingolipid, 0.01-1.0 % by weight of salicylic acid, 0.01-5% by weight of Candida bombicola metabolite, 0.1-10% by weight of lactic acid, 20-% of isopropyl alcohol. 60 weight percent and 13 5-29.87 weight percent purified water. Moreover, as a preferable manufacturing method of this invention,

1) dissolving sphingolipid in ethanol,

2) dissolving salicylic acid in isopropyl alcohol in a separate dissolution tank,

3) Candida bombicola fermentation metabolite, lactic acid, and purified water were added and dispersed in 1) and 2) prepared above, followed by filtration. In this manufacturing method, the steps of 1) and 2) may further include mixing by adding one or more selected from fragrances, preservatives and another active ingredient.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited by Examples.

Example 1

It was prepared according to the composition shown in Table 1, the production method is as follows.

The components of phase A were completely dissolved and the components of phase B were completely dissolved in a separate dissolution bath, followed by addition of phase A to phase B to homogenize mixing. The components of the C and D phases were added sequentially, homogenized and filtered to prepare the composition.

Example 2

Prepared in the same manner as in Example 1, the composition is shown in Table 1 below.

Comparative Example 1

In order to compare with the case of the examples, an excipient and a composition containing antibiotics were prepared, respectively, and the composition ratios are shown in Table 2. In the manufacturing method, the components of phase A were completely dissolved, and then components of phases B and C were sequentially added to each other, homogenized, mixed, and filtered to prepare a composition.

Comparative Examples 2 and 3

It was prepared in the same manner as in Comparative Example 1, the composition is shown in Table 2 below.

Test Example

1) Antibacterial test

Each cosmetic composition prepared in the compositions of Examples 1, 2 and Comparative Examples 1 to 3 were tested for antibacterial activity against Propionibacterium acnes , a strain of acne-causing strains, and the results are shown in Table 3 below. Disc plate method was used as an irradiation method. This method is characterized by spreading the P. acnes strain on agar plate medium and incubating with a paper disc treated with the Examples and Comparative Examples composition, and then examining the size of the generated inhibition zone (inhibition zone). The susceptibility to was investigated.

2) Clinical trial: efficacy and side effects

Example 4 and Comparative Example 2 were applied to a blind spot where acne occurred in 30 acne patients, and the comparison results are shown in Table 4 below.

As can be seen from Table 4, in Example 2 and Comparative Example 2, it can be seen that the effect on the acne. However, in the case of the use of Comparative Example 2 compared to Example 2, the stimulation is relatively severe (about 10% of the clinical investigator), it is burdensome to use in the long term, while in Example 2, while the stimulation is relatively good ( About 4% of the clinical investigators were also very mild, allowing for continued use. Thus, in case of Example 2, acne recurrence rate was almost never (within 1%) due to continuous use, whereas in Comparative Example 2, acne recurrence phenomenon appeared due to discontinuation (about 20%). Therefore, when comparing comprehensively with various factors such as irritation and severity, the possibility of recurrence, healing effect, it can be seen that the case of Example 2 is more suitable for patients with acne skin.

As described above, the cosmetic composition having an effect on the acne skin according to the present invention enables the long-term use without irritating the skin by simultaneously preventing the clogging of the skin and inhibiting the growth of the acne-causing strains. And care has the effect of providing a very safe cosmetic composition that minimizes the likelihood of recurrence as well as the treatment of acne.

Claims (4)

A cosmetic composition having an acne healing effect on acne skin, wherein the cosmetic composition has a uniform structure by dissolving and dispersing sphingolipid, Candida bombicola fermentation metabolite, salicylic acid, and lactic acid in an excipient of ethanol and isopropyl alcohol. The composition of claim 1, wherein the composition comprises 10-50 wt% ethanol, 0.01-0.5 wt% sphingolipid, 0.01-1.0 wt% salicylic acid, 0.01-5 wt% Candida bombicola fermentation metabolite, 0.1-10 wt% lactic acid, Cosmetic composition, characterized in that it contains 20 to 60% by weight of isopropyl alcohol, 13.5 to 29.87% by weight of purified water. In the method for producing a cosmetic composition having a therapeutic effect on acne skin, 1) dissolving sphingolipid in ethanol, 2) dissolving salicylic acid in isopropyl alcohol in a separate dissolution tank, 3) The method for preparing a cosmetic composition comprising the step of dispersing by adding the prepared 1), 2) Candida bombicola fermentation metabolite, lactic acid, purified water and then filtration. According to claim 3, wherein each of the steps 1), 2) Cosmetics, characterized in that it further comprises the step of adding and mixing at least one selected from fragrance, preservatives and another active ingredient having an acne treatment effect Method of Preparation of the Composition.