KR20020049165A - Composition having bactericidal action, and cosmetic material and uv blocking material comprising the composition - Google Patents

Abstract

PURPOSE: Provided are a composition having a sterilization activity, and cosmetics and UV blocking agents containing the same. The composition having a sterilization activity shows excellent therapeutic effects on dermatological diseases, such as a pimple, atopic dermatitis and the like. CONSTITUTION: The composition having a sterilization activity is characterized by comprising an extract of silk gland and/or liquid silk, as an active ingredient. In particular, the extract is obtained from the mixture of silk gland, a silkworm, raw silk and a silkworm pupa with an organic solvent, and optionally concentrated.

Description

A composition having a bactericidal action, a cosmetic and a sunscreen material composed of the composition {COMPOSITION HAVING BACTERICIDAL ACTION, AND COSMETIC MATERIAL AND UV BLOCKING MATERIAL COMPRISING THE COMPOSITION}

The present invention particularly relates to a composition having a bactericidal action giving excellent effects on beauty and health of the skin and the like, and a cosmetic and a sunscreen material comprising the composition.

It is well known to add vitamins, self-administration, hyaluronic acid and various other additives to skin cosmetics in order to maintain healthy physiological function of the skin and to maintain healthy and beautiful skin.

In addition, when applied directly to the skin as an external preparation, medicinal cosmetics have been proposed that activate the function of the skin and help regeneration of the skin without harming the skin.

However, the cosmetics or medicines which completely heal atopic dermatitis, acne, etc. in a short time are not known at all.

On the other hand, silk has been conventionally used as a raw material for high-quality clothing, and it is known that a certain amount of efficacy can be obtained by wearing underwear made of silk.

However, it is not known at all about what medicinal component is contained in a silk wine, and also about isolating the component which has the medicinal effect.

In addition, there are many known substances having a bactericidal action, but most of them are extremely toxic to the human body. As a bactericide which is not toxic to humans, "garlic" is known, but "garlic" has a problem of producing a great bad smell.

On the other hand, conventionally known nutritional or medicinal creams for skin containing pupa oil and cocoon extract from cocoon have been known. However, these conventional pupa oils and medicinal creams do not have a bactericidal action.

An object of the present invention is to provide a composition having a bactericidal action which is not toxic to the human body.

Moreover, an object of this invention is to provide the composition which has a bactericidal effect which has the outstanding therapeutic effect especially in skin diseases, such as atopic dermatitis and acne.

Another object of the present invention is to provide a cosmetic having a bactericidal effect of activating the metabolism of the surface of the skin and the like to prevent skin deterioration, smoothing the skin, and making the spots and pigmentation of the skin unnoticeable. It is done.

Furthermore, an object of the present invention is to provide a sunscreen which is not toxic to the human body, which has an excellent effect on skin diseases and the like and which has a bactericidal action.

In order to achieve the above object, the present inventors have made a thorough study, and as a result, water or organic solvent extracts from silk gland and / or liquid dog show excellent bactericidal action and have atopic dermatitis. It has an absolute effect on improving the treatment of acne and skin roughness, and actively metabolizes the surface of the skin without harming the skin, thereby preventing skin breakdown, smoothing the skin, and excellent UV protection. It was found to have and the present invention was reached.

That is, the present invention is characterized in that it has a bactericidal action using an extract from silk glands and / or liquid dogs as an active ingredient.

The above and other objects and advantages of the present invention will become apparent from the following description.

(Detailed Description of the Preferred Embodiments)

Next, an embodiment of the present invention will be described.

The raw material used in the present invention is silk gland and / or liquid silk, preferably silk gland in a state in which a liquid dog is accommodated. However, in order to reduce the raw material cost, the raw silk is again subjected to silk gland. silk filament), silkworm cocoon, silk thread produced from silkworm cocoon, silk or silkworm pupa may be used in combination. It is preferable to use finely cut or powdered raw materials such as silkworm cocoons in order to increase the extraction effect.

The content of the silk gland and / or the liquid dog in the raw material of the present invention is 5% or more, preferably 10% to 50%. If too small, the sterilization action will be insufficient, and if too large, the raw material cost will be high, and there is no advantage.

There are many kinds of silkworms for producing the above-mentioned raw materials, but any kind of silkworm can be used as the raw material of the present invention. However, it is preferable to use silkworms for 3 to 5 years 4 and 5 days, especially just before spitting the silk gland (5 to 5 years old 4 and 5 days). It is because the liquid dog in a silk gland becomes a gel form, and is especially effective as a raw material of this invention.

If the silk gland containing the liquid dog is taken out from the silkworm immediately before spitting the silk gland, and it is not immediately used as a raw material, it is better to rapidly freeze and store it. This is because the active ingredient does not deteriorate.

By extracting from these raw materials with water or an organic solvent, the active ingredient of this invention can be isolated. As the organic solvent, alcohols and those having no toxicity are preferable, in particular, ethyl alcohol is preferably used.

The extraction temperature is good at room temperature, but in order to increase the extraction effect in a short time, it is better to extract by heating.

The active ingredient of the present invention is obtained by adding the silk gland and / or the liquid dog as it is, with water or an organic solvent, preferably extracted for several hours under boiling, filtration and concentrated to dryness of the filtrate.

The active ingredient of the present invention thus obtained has a bactericidal action and exerts excellent efficacy against the following symptoms.

(Atopic dermatitis, sensitive skin)

Since the active ingredient of the present invention has an antiallergic effect, it shows an excellent effect on allergic dermatitis (sensitization) such as atopic dermatitis, hand washing, eczema and contact dermatitis by synthetic detergents.

(Pollutosis, cataract)

The hay fever of rhinitis and itching of the eye is completely healed by rubbing it directly on the affected part. Even for cataracts, there are roadways in a short time by rubbing directly on the affected part.

(Spot, pigmentation of the skin)

Since the active ingredient of the present invention promotes metabolism of the skin, it is noticeably disappeared in a short time by rubbing the skin spots, pigmentation, etc.

(Dry skin)

The active ingredient of the present invention exhibits a quick effect of stopping the itching and skin improvement by metabolism against the itching caused by the dry skin of winter.

(Numbness, splitting, cuts, burns, scratches, statues, bedsores)

The active ingredient of the present invention may be rubbed directly on the affected part, but it is more effective if it is applied to a gauze or the like and used against the affected part.

(Skin diseases such as stinging, acne, eczema, athlete's foot, perfection, warts, insect bites, etc.)

By the function of the active ingredient of the present invention, the metabolism of the affected area becomes active, and when rubbed on the affected area, itching is stopped immediately and there is a driveway.

Hemorrhoids and prostate hypertrophy

The closer the affected part, such as periarthritis to the outside, the more effective it is rubbed on the affected area, there is an immediate drive. With respect to the enlarged prostate, there is an immediate driveway by rubbing the affected area in the same manner.

Stomatitis

Although the active ingredient of the present invention has a bactericidal action, it is not toxic to the human body, so it is safe and completely cured in a short time even against diseases in the mouth.

(Odor)

By rubbing the active ingredient of the present invention on the affected part, the metabolism of the skin is active and the constitution is improved, so there is a difference immediately.

(Wrinkles, fine lines)

By rubbing the active ingredient of the present invention on the wrinkled part, the wrinkles become inconspicuous and the skin becomes smooth.

The cosmetic of this invention is obtained by adding the active ingredient of the said invention to a cosmetics base. As a cosmetic base, a well-known thing may be used and it is not specifically limited.

The formulation of the cosmetics used in the present invention is not particularly limited, and examples thereof include creams, lotions, packs, foundations, shampoos, rinses, hair tonics, baths, soaps and the like.

Although the addition amount of the active ingredient of this invention to a cosmetic base can be changed widely, For example, it is preferable to add about 0.1-25 weight% as a concentrate remove | excluding the solvent.

Also in the cosmetics obtained in this way, it is confirmed by experiment that the same effect as the said active ingredient is obtained.

The active ingredient of the present invention has a sunscreen action. Therefore, when the active ingredient of the present invention is added to the cosmetic base by about 0.1 to 25% by weight as the concentrate, it is possible to obtain a sunscreen action such as a cream that prevents sunburn, especially without adding an ultraviolet absorbent. In addition, the active ingredient of the present invention has a function of dissolving melanin pigment. Therefore, when the cream of the present invention is applied to sunburned skin, the effect of preventing sunburn and whitening of the skin is also exhibited.

The active ingredient of the extract from one or more raw materials of silk dog, silkworm cocoon, raw silk, silkworm and silkworm pupa, which do not contain silk gland and / or liquid dog, also has a sunscreen action. However, compared with the active ingredient of the present invention, the effect is inferior.

Examples of the present invention are shown next, but the present invention is not limited to these examples. "Part" which shows a quantity in an example is a weight part.

(Example 1)

20 parts of silk glands (with liquid dogs) and 200 parts of silkworm cocoons were added and 200 parts of water were boiled for 3 hours. Then, it filtered and the filtrate was concentrated under reduced pressure. 50 parts of active ingredients of this invention were obtained as a concentrated pale yellow liquid.

Example 2: Cream

13 parts of active ingredient obtained in Example 1

5 parts ethanol

Beeswax part 6

Squalane Part 20

Fatty acid glycerin ester part 4

Emulsifiers Part 4

1,3-butylene glycol3parts

Alpha-bisabolol (Eco 101) 0.3

44.7 parts of purified water

The said component is mixed homogeneously in said ratio, and the cream of this invention is obtained.

Example 3: Hair Tonic

10 parts active ingredient obtained in Example 1

Ethanol55.3Part

Menthol 4.4

Alpha bisabolol (Eico 101) 0.3 part

34.3 parts

The said component is mixed homogeneously in said ratio, and the hair tonic of this invention is obtained.

Example 4: Shampoo

10.0 parts of active ingredient obtained in Example 1

N-palm fatty acid acyl-L glutamic acid mono

Triethanol amine26.0 parts

Alpha-bisabolol (Eico-101) 0.5part

Sodium Lauryl Ether

Propylene glycol2.0 parts

37.5 parts of purified water

The said component is mixed homogeneously in said ratio, and the shampoo of this invention is obtained.

Example 5 Efficacy on Atopic Dermatitis

Three women who suffer from atopic dermatitis whose skin condition is apparent in appearance are taken as a test subject, and the cream obtained in Example 1 is rubbed with a small amount of lightly diluted on the face once a day in a normal amount, and visually observed. It was. The results are shown in Table 1 below.

Subject No. age job Elapsed days 1 week 1 month 3 months One 15 student + ○ 2 18 student ± ○ 3 35 OL ± + ○

However, ± … Symptoms improved compared to before use.

+… … The symptoms were not noticeable.

○… … It was completely cured.

As is clear from the above results, the application of the cosmetic of the present invention improves the condition for atopic dermatitis in one week and is cured at least three months later.

Example 6 Efficacy on Acne

Five women who suffered from acne with apparently apparent skin conditions were examined, and the cream obtained in Example 1 was rubbed with a small amount of lightly diluted on the face once a day in the usual amount of use and visually observed. The results are shown in Table 2 below.

Subject No. age job Elapsed days 1 week 1 month 3 months One 13 student ± ○ 2 15 student ± ○ 3 18 student ± + ○ 4 21 OL ± ○ 5 22 OL ± + ○

However, ± … Less acne compared to before use.

+… … The symptoms were not noticeable.

○… … It was completely cured.

As apparent from the above results, when the cosmetic of the present invention is applied, the condition is improved for acne for one week and cured at least three months later.

Example 7 Efficacy of Various Symptoms

The cream of the present invention obtained in Example 1 was rubbed with a small amount of lightly diluted in the affected area at a daily usage amount to the subject who was troubled with the symptoms described in the following Table 3, and the progress was visually observed. The results are shown in Table 3 below.

Symptom Progress Spots on the skin The spots on the skin became small in one week and were inconspicuous at three months. bedsore Soon the pain subsided and healed in one month. Hay fever Itching soon stopped and healed in one month. Athlete's foot Itching soon healed and healed in one month. hemorrhoids Soon the pain subsided and healed in one month. Stomatitis Soon the pain subsided and healed in one month. Cataract The effect appeared in two to three days and was cured in one month. Fine lines It becomes inconspicuous in about a week and becomes smooth.

As apparent from the above results, when the cosmetic composition of the present invention is applied, pain and itching are soon resolved, and even if it is a symptom that it is difficult to cure conventionally such as spots on the skin, it is cured at least three months later.

Example 8 The efficacy of the cream containing only raw silk was compared with the cream containing silk thread as a raw material.

(A) Cream using only raw sand: Comparative cream was prepared in the same manner as in Example 1 except that 20 parts of silk thread and 300 parts of silk thread were used instead of 200 parts of silkworm cocoons.

(B) Cream containing a silk gland as a raw material: The cream of this invention was produced like Example 1.

The smell and feeling of use of the cream of the present invention and the comparative cream were compared.

(1) Odor: In the case of raw silk only, if the fragrance is not used, the characteristic smell of raw silk remains.However, if the silk silk is the main ingredient, if you rub it lightly on the skin without adding the fragrance, it will penetrate into the skin. none.

(2) Hand touch: In the case of raw silk only, there is a crunchy feeling. However, the silk-based silk is moist and smooth.

(3) When applied to the affected area: In the case of raw silk alone, it has a feeling of roughness and sticky sensitivity, but the silk-based main ingredient is smooth, and it is smooth and there is no sticky feeling, so it is absorbed moist. Can be.

The cream and the comparative cream of the present invention compared the drug effect against various diseases.

(1) Atopic dermatitis: It was applied to the affected part at a normal usage once a day. Comparative cream took 7-14 days to soothe itching and was ineffective at improving symptoms. The cream of the present invention soon calmed the itch, improved the symptoms in one week, and cured at least three months. In addition, when the cream of the present invention was applied to the patient whose face was washed away by the use of an adrenal cortical hormone, it was completely cured in half a year.

(2) Flesh breaks of the hands and feet: The affected areas were applied once a day at normal usage. Comparative cream took 15 to 30 days to soothe itching and 1 to 3 months to improve symptoms. The cream of the present invention immediately sed the itching and pain and the symptoms improved for one week.

(3) Athlete's foot: It was applied to the affected part at a normal usage amount once a day. Comparative cream took 2-5 days to soothe itching, and no improvement of symptoms was seen. The cream of the present invention immediately relieved itching and improved its symptoms for one week even if the affected skin was not skinned.

(4) Shoulder stiffness: It was apply | coated to the affected part by normal usage. Although the comparative cream is recognized for about 30 minutes after application to the affected part, the cream of the present invention immediately reminds the affected part and warms up, and the stiffness and pain are quenched immediately.

(5) Bruises: It was apply | coated to a wound part by normal usage. Comparative cream, after application to the affected area, the effect was recognized about 30 minutes, but swelling or congestion left skin spots. The cream of the present invention applied to the affected area as soon as the pain of the affected area was soothed and swollen, no congestion, and no spots occurred.

(6) Hemostatic action: When a finger or the like is cut on a sharp object, even if applied to the affected area, the comparative cream does not recognize the effect, but if the present invention cream is applied to the affected area and tied up, the wound may not be closed in one day. The blood stops and the wound is filled.

(7) Pain and hemorrhage of hemorrhoids: Even if applied to the affected area, the comparative cream was not recognized as effective, but the cream of the present invention had pain in 5 minutes in the case of anal laceration, and the bleeding also stopped immediately. In the case of anti-hanging, the number of times the cream of the present invention is applied after bathing gradually decreases. In the case of pulp, when the cream-coated gauze of the present invention was placed on the affected area, symptoms improved in one month.

(8) Burns: When the normal amount is applied to a hot and inflamed affected area, the comparative cream is not effective, but the cream of the present invention catches pain and inflammation within a few minutes. It doesn't work.

(9) Nasal congestion: The comparative cream was not recognized for effect, but when the cream of the present invention was applied to the nose blade, the nose immediately passed.

(10) Cough: The comparative cream is not recognized for its effect, but when the cream of the present invention is applied to the nose, neck, chest, and the like, the cough stopped about 1 hour.

(11) acne; Comparative cream was not recognized, but when the cream of the present invention is rubbed with a mild thinning of the affected area at a daily daily use, the symptom is improved in one week and cured in one to three months.

(12) Bed sores: Even if the comparative cream is applied to a person who is aging or sick only because of bedding, the effect is not recognized.However, when the cream of the present invention is applied to the affected area, the pain is calmed and the wound is gradually reduced. Cured at 2 weeks.

Although the effect is not recognized by the cream of the comparative example, as the effect recognized by the cream of this invention, there exist skin spots, hay fever, stomatitis, fine wrinkles, alveolar pylori, prostatic hypertrophy, etc. in addition to the above. 10 years of experience, the main component of silk glands is bactericidal, anti-inflammatory (anti-itch, pain, inflammatory), anti-allergic, hemostatic. In addition, no side effects were recognized for 10 years.

Example 9 UV Protection Effect

In order to confirm the UV protection effect between the cream of the present invention and the comparative cream, each cream was coated on a glass plate with a film thickness of 20 μm, and an ultraviolet spectrophotometer was used to measure the UV transmittance at 300 nm, and the UV blocking rate ( UV cut rate) was obtained. The results are shown in Table 4 below. Here, UV blocking rate (%) = 100 (%)-ultraviolet ray transmission rate (%). Furthermore, except for not adding an active ingredient for comparison, the UV protection rate was measured for the control creams prepared in the same manner, and the results are shown in Table 4 below.

Cream UV transmittance Invention cream 75% Comparison cream 60% Contrast Cream 40%

According to the present invention, it has no toxicity to the human body, has a bactericidal action, and has an absolute therapeutic effect on skin diseases such as atopic dermatitis and skin spots, which have been extremely difficult to cure in the past.

In addition, the cosmetics of the present invention have an absolute effect on all skin diseases, promote the metabolism of the skin surface, prevent skin weakness, smooth the skin, make the skin spots and pigmentation stand out It can make a remarkable effect that can not be seen at all in the conventional cosmetics.

In addition, according to the sunscreen material of the present invention, in addition to the above effects in addition to the above effects when the cosmetics have an excellent effect on skin diseases and the like, the effect of preventing the skin from blacking in the sun, such as adding a non-toxic ultraviolet absorber At the same time, it achieves no action at all with this type of conventional sunscreen that whitens blackened skin.

Claims (7)

A composition having a bactericidal action, characterized in that the extract from silk glands and / or liquid dogs is an active ingredient. The composition according to claim 1, further comprising an extract from a mixture obtained by adding one or two or more of silkworm silkworm, cocoon, silk thread, silkworm and pupa to silkworm as an active ingredient. The method of claim 1, wherein the composition is atopic dermatitis, allergic dermatitis, skin spots, pigmentation, skin roughness, fine wrinkles, acne, sweat bands, skin paws, burns, insect stings, dry skin, eczema, bedsores , Hay fever, athlete's foot, completeness, prostatic hypertrophy, hemorrhoids, warts, liquid odors, stomatitis, alveolar pylori or cataracts. The composition having a bactericidal action according to claim 1, wherein the extract is water or an organic solvent extract or a concentrate obtained by concentrating the extract. A cosmetic having a bactericidal action, characterized by blending water or an organic solvent extract from silk glands and / or liquid dogs with a cosmetic base. Ultraviolet with bactericidal action, characterized in that the extract from the mixture which added one or two or more of pupa of silk glands, liquid dogs, silk glands, silkworm cocoons, raw silk, silkworms and silkworms as an active ingredient Barrier materials. 7. A sunscreen material according to claim 6, characterized in that water or organic solvent extract from silk glands and / or liquid dogs is used as an active ingredient.