KR20020040685A - Cosmetic compositions containing pantothenic acid - Google Patents

Abstract

In the present invention there is provided a cosmetic composition comprising:

(a) one or more quaternary ammonium preparations; And

(b) more than 0.5% pantothenic acid or pantothenic acid derivatives and mixtures thereof.

The compositions of the present invention provide benefits associated with pantothenic acid or pantothenic acid derivatives such as wound healing and skin protection while reducing associated negative aspects such as irritation, adhesion and / or stickiness.

Description

Cosmetic composition containing pantothenic acid {COSMETIC COMPOSITIONS CONTAINING PANTOTHENIC ACID}

The skin consists of several layers of cells that coat and protect keratin and collagen fibrous proteins that form the framework of its structure. The outermost layer, called the stratum corneum, is known to consist of a 25 nm protein bundle surrounded by an 8 nm thick layer. Anionic surfactants and organic solvents usually penetrate the stratum corneum and disrupt its integrity by degreasing (ie, removing lipids from the stratum corneum). This disruption of skin surface topography can cause a rough feel and, consequently, irritation, allowing the surfactant or solvent to interact with keratin. Many people expose their skin to this type of injury every day. In addition, the skin may be damaged by other factors such as exposure to the sun, exposure to cold air, mechanical friction, water infiltration, and the like. Thus, there is a need for a method of mitigating or ameliorating such damage.

In the past, compositions have been formulated that claim to help maintain the stratum corneum with optimal performance despite the harmful interactions the skin may face during washing, working and recreation. Preferred properties for these compositions are that they have good skin feel, water retention, moisturizing, adsorptive and / or rubbing properties. Prior art compositions are intended to impart this property by the use of one or more 'skin benefit agents'. For example, panthenol, an alcoholic form of pantothenic acid, is known for use in skin care products such as shampoos and skin lotions. Panthenol, for example in combination with zinc oxide, has been reported to provide accelerated surface wound healing (H. Weise et al., "Acceleration of Superficial Wound Healing by Panthenol Zinc Oxide," Cosmetics and Toiletries, vol. 103, pp. 79- 84, October 1988].

There seems to be a direct relationship between the amount of skin active agent and the effectiveness of the composition to benefit the skin. However, it is also the case that the higher the level of skin active agent, the higher the risk of associated negative aspects. Thus, to date, it has been necessary to balance the benefits of compositions comprising high levels of skin active agent against the negative aspects associated with these high levels. Thus, it contains a high level of skin active agent and thus provides a high level of associated benefits such as skin feel, skin softness and skin smoothness, but low levels of associated negative aspects such as irritant, slippery, sticky or tacky There is a need for compositions that exhibit.

Quaternary ammonium preparations are also known for use in cosmetic compositions. See, eg, WO-A-99 / 27904, WO-A-96 / 32089 and EP-A-789,076. See also US Pat. No. 5,804,205, which discloses the claimed skin care composition to provide a high level of moisturization without leaving "sticky" or "sticky". The composition contains a quaternary ammonium compound having two alkyl groups having 16 to 22 carbon atoms, a humectant, and a nonirritating hydrophobic microsphere having an average particle size of less than 50 μm. It is claimed that hydrophobic polymerizable microspheres significantly reduce the "tackiness" associated with high humectant levels. The compositions of US-A-5,804,205 may contain low levels of softeners such as mineral or mineral oils.

Compositions comprising one or more quaternary ammonium preparations and greater than 0.5% pantothenic acid or pantothenic acid derivatives and mixtures thereof provide good skin benefits and are currently unexpectedly found to protect skin. The composition has improved user acceptance and promotes better user compliance with the accompanying overall improved skin care benefits.

Without wishing to be bound by theory, it is believed that the quaternary ammonium preparations of the present invention induce degradation of pantothenic acid or pantothenic acid derivatives on the skin. This ensures that the maximum skin benefit is derived from the active agent while minimizing negative aspects such as irritation, stickiness and / or stickiness. Quaternary ammonium preparations also help to reduce the loss or friction of active agents from the skin due to environmental factors such as water. In addition, the quaternary ammonium formulations themselves are believed to confer skin care benefits such as good moisturizing, good skin feel, good skin softness.

[Overview of invention]

In the present invention there is provided a cosmetic composition comprising:

(a) one or more quaternary ammonium preparations; And

(b) more than 0.5% pantothenic acid or pantothenic acid derivatives and mixtures thereof.

The compositions of the present invention provide benefits associated with pantothenic acid or pantothenic acid derivatives such as wound healing and skin protection while reducing associated negative aspects such as irritation, adhesion and / or stickiness.

The present invention relates to a cosmetic composition. In particular, the present invention relates to cosmetic compositions for the treatment of skin.

The composition of the present invention contains at least one quaternary ammonium preparation and more than 0.5% pantothenic acid or pantothenic acid derivatives and mixtures thereof. These components will be described in more detail below.

The composition of the present invention can be used for any suitable purpose. In particular, the compositions of the present invention are suitable for topical application to the skin. In particular, the skin care composition may be in the form of a cream, lotion, gel or the like. In the present invention preferably the cosmetic composition is an aqueous continuous, wherein each oil phase contains a single oil component or a mixture of oil components in a miscible or homogeneous form, wherein the different oil phases comprise different substances or combinations of different substances. At least one oil phase of the phase is in the form of an oil-in-water emulsion.

The composition of the present invention preferably contains an endoplasmic reticulum. Preferably the endoplasmic reticulum contains quaternary ammonium preparations and pantothenic acid or pantothenic acid derivatives. The term "vesicle" as used herein means one or more bilayers arranged in a closed, typically spherical geometry, containing the quaternary ammonium preparation, which is described below.

Preferably the composition of the present invention contains less than 10% by weight, preferably less than 5% by weight, more preferably less than 3% by weight, even more preferably 0% by weight of anionic surfactant.

Preferably, the composition of the present invention is at least about 1,000 mPa · s, preferably from about 1,000 to about 300,000 mPa · s, more preferably from about 2,500 to about 250,000 mPa · s, in particular from about 5,000 to about 200,000 mPa · s. Formulated to have product viscosity (26.8 ° C., neat, Brookfield DV-II + Spindle CP52 / CP41).

Quaternary Ammonium Formulations

The composition of the present invention should contain at least one quaternary ammonium preparation. Any quaternary ammonium formulation suitable for use in cosmetic compositions can be used in the present invention. As used herein, the term "quaternary ammonium preparation" means a compound or mixture of compounds having a quaternary nitrogen atom substituted with one or more, preferably two, parts of 6 or more carbon atoms. Preferably the quaternary ammonium preparations for use in the present invention are selected from those having quaternary nitrogen substituted in two parts each having at least 10 additional carbon atoms, preferably at least 12 carbon atoms. Quaternary ammonium preparations highly preferred for use in the present invention are selected from those capable of forming vesicles in polar solvents detected by microscopic analysis (polarized optical microscope at x60 magnification using a Nikon Eclipse E800 microscope).

Preferably, the composition of the present invention contains at least 0.01% by weight, more preferably at least 0.1% by weight, even more preferably at least 1.5% by weight, even more preferably at least 3% by weight of quaternary ammonium preparation.

Preferably the quaternary ammonium preparation used in the present invention is selected from:

(a) quaternary ammonium compounds of formula I:

[Wherein, R ₁ and R ₂ are each a C ₁ -C ₄ alkyl or C ₁ -C ₄ hydroxyalkyl group or hydrogen, and R ₃ and R ₄ are each an alkyl or alkenyl group having from about 8 to about 22 carbon atoms. X ⁻ is a salt forming anion and is compatible with quaternary ammonium compounds and other additional ingredients.

Preferred quaternary ammonium compounds of this kind are those in which R ₁ and R ₂ are methyl or hydroxyethyl and R ₃ and R ₄ are linear or branched alkyl or alkenyl chains having at least 11 carbon atoms, preferably at least 15 carbon atoms. Quaternized amine with

(b) quaternary ammonium compounds of formula II or III:

[Wherein each R ₅ unit is hydrogen, branched or linear chain C ₁ -C ₆ alkyl, branched or linear chain C ₁ -C ₆ hydroxyalkyl and mixtures thereof, preferably methyl and hydroxyethyl Independently selected from; Each R ₆ unit is independently linear or branched C ₁₁ -C ₂₂ alkyl, linear or branched C ₁₁ -C ₂₂ alkenyl, and mixtures thereof; X ⁻ is an anion that is compatible with the skin care active agent and additional ingredients; m is 1 to 4, preferably 2; n is 1 to 4, preferably 2 and Q is a carbonyl unit selected from:

(Wherein R ₇ is hydrogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ hydroxyalkyl, and mixtures thereof).

In the example of the quaternary ammonium compound, unit -QR ₆ comprises a fatty acyl unit which is typically derived from a triglyceride source. The triglyceride source is preferably tallow, partially hydrogenated tallow, lard, partially hydrogenated lard, vegetable oil and / or partially hydrogenated vegetable oil such as canola oil, safflower oil, peanut oil, rapeseed oil, sunflower oil , Corn oil, soybean oil, tall oil, rice bran oil, and the like, and mixtures of these oils.

The counterion in the compound, X ^−, may be any compatible anion, preferably a strong acid, such as chloride, bromide, methylsulfate, ethylsulfate, sulfates, nitrates, etc., more preferably chlorite or It is an anion of methyl sulfate. In addition, the anion may carry a double charge, less preferably when X ⁻ represents a half group.

Preferred quaternary ammonium compounds of the present invention are diester and / or diamide quaternary ammonium (DEQA) compounds wherein the diester and diamide are of formula II wherein the carbonyl group Q is selected from:

Tallow, canola and palm oil are the sources of convenient and inexpensive fatty acyl units suitable for use as R ₆ units in the present invention.

The counterion X ⁻ may be chloride, bromide, methylsulfate, formate, sulfate, nitrate and mixtures thereof. In fact, the anion X only exists as the counterion of the positively charged quaternary ammonium compound. It is not intended that the scope of the invention be limited to any particular anion.

As used herein, when diesters are specified, they will include monoesters and triesters which are usually present as a result of the manufacturing process.

(c) quaternary ammonium compounds of formula IV or V:

[Wherein R ₉ is a bicyclic aliphatic C ₁₅ -C ₂₁ hydrocarbon group and R ₁₀ is a C ₁ -C ₆ alkyl or alkylene group].

Such ammonium compounds having pKa values of about 4 or less can induce cationic charges when dispersed in aqueous solutions, resulting in a pH of about 6 or less in the final composition.

(d) quaternary ammonium compounds of formula VI or VII:

Wherein R ₉ and R ₁₀ are as specified above and R ₁₁ is selected from C ₁ -C ₄ alkyl and hydroxyalkyl groups.

The counterion, X ⁻ can be chloride, bromide, methylsulfate, formate, sulfate, nitrate, and mixtures thereof. In fact, the anion X only exists as the counterion of the positively charged quaternary ammonium compound. It is not intended that the scope of the invention be limited to any particular anion.

(e) quaternary ammonium compounds of formula VIII or IX:

[Wherein n is 1 to 6, R ₉ is selected from bicyclic aliphatic C ₁₅ -C ₂₁ hydrocarbon groups, and R ₁₂ is selected from C ₁ -C ₄ alkyl and hydroxyalkyl groups].

Such ammonium compound (VIII) having a pKa value of about 4 or less, when dispersed in an aqueous solution, can generate a cationic charge inherently, resulting in a pH of about 6 or less in the final composition.

Counterion X ^- (IX) may be chloride, bromide, methyl sulfate, formate, sulfate, nitrate, and mixtures thereof. In fact, the anion X only exists as the counterion of the positively charged quaternary ammonium compound. It is not intended that the scope of the invention be limited to any particular anion.

(f) diquaternary ammonium compounds of formula X, XI, XII or XIII:

[Wherein R ₅ , R ₆ , Q, n and X ⁻ are as defined above in connection with formulas II and III, R ₁₃ is a C ₁ -C ₆ alkylene group, preferably an ethylene group, z is 0 to 4].

(g) a mixture of said quaternary ammonium compounds.

Preferred quaternary ammonium preparations for use in the present invention are those described in section (b) above. Especially preferred are diesters of formula (II) and / or diamide quaternary ammonium (DEQA) compounds. Preferred diesters for use in the present invention are those of formula II wherein R ₅ , R ₆ , and X ⁻ are as defined above and Q is

Preferred diamides for use in the present invention are those of formula II wherein R ₅ , R ₆ , and X ⁻ are as defined above and Q is

Preferred examples of quaternary ammonium compounds suitable for use in the compositions of the present invention are N, N-di (canolyl-oxy-ethyl) -N, N-dimethyl ammonium chloride, N, N-di (canolyl-oxy- Ethyl) -N-methyl, N- (2-hydroxyethyl) ammonium methyl sulfate, N, N-di (canolyl-oxy-ethyl) -N-methyl, N- (2-hydroxyethyl) ammonium chloride And mixtures thereof. Particularly preferred for use in the present invention is N, N-di (canolyl-oxy-ethyl) -N-methyl, N- (2-hydroxyethyl) ammonium methyl sulfate.

While it is preferred that the quaternary ammonium compound is derived from a "canolyl" fatty acyl group, another suitable example of a quaternary ammonium compound is derived from a fatty acyl group, in which the term "canolyl" is derived from a fatty acyl unit. Replaced with the term “taloyl, cocoyl, palmyl, lauryl, oleyl, ricinoleyl, stearyl, palmityl”, corresponding to triglycerides. Such alternative fatty acyl sources may contain fully saturated, or preferably at least partially unsaturated chains.

Pantothenic Acid Derivatives

The composition of the present invention also comprises more than 0.5% by weight pantothenic acid and / or pantothenic acid precursors or derivatives and mixtures thereof. Pantothenic acid, also known as N- (2,4-dihydroxy-3,3-dimethylbutyryl) -B-alanine, is a source of B complex vitamins and is often known as vitamin B ₅ . Pantothenic acid is an essential dietary ingredient for most mammals. The substance can exist in D (+) form, L (−) form, and racemate. The Merck Index, 10th Amendment, Listing 6877, p. 1007 (1983).

Various pantothenic acid precursors or derivatives are known and / or can be synthesized. Non-limiting examples include alcohols, aldehydes, alcohol esters, acid esters, and the like. A suitable example is U.S. Patent number 3,230,228; No. 4,514,338; No. 4,602,036; No. 5,136,093; And 5,750,122. Alcohol derivatives of pantothenic acid are particularly preferred for use in the compositions of the present invention. Panthenol, pantothenol, pantothenyl alcohol and these alcohols, also known as 2,4-dihydroxy-N- (3-hydroxypropyl) -3,3-dimethylbutanamide, are stable sources of pantothenic acid activity. Like the parent acid, panthenol can exist as D (+) type, L (−) type, and racemate. The Merck Index, revised 10, list 2910, p. 426 (1983).

Pantothenic acid precursors or derivatives are effective for reducing the irritation caused by vitamin B ₃ compounds as a result of personal factors (eg hypersensitivity) and / or environmental conditions. With regard to environmental conditions, the irritant reducing composition of the present invention preferably has an environmental temperature of 20 ° C.-55 ° C., preferably 25 ° C.-50 ° C., most preferably 30 ° C.-45 ° C., and / or 50% to 100 %, Preferably 65% to 100%, most preferably 80% to 100% relative humidity.

Pantothenic acid and / or pantothenic acid precursors or derivatives of the compositions useful in the present invention are preferably present in amounts of 0.6% to 10%, more preferably 0.75% to 5%, even more preferably 0.85% to 3.5% by weight. do.

The composition of the present invention preferably contains 0.6% to 10% by weight, more preferably 0.75% to 5% by weight, even more preferably 0.85% to 3.5% by weight of panthenol. D-panthenol, also known as dexpanthenol, is particularly preferred for use herein.

Random ingredient

The compositions herein may contain various optional ingredients suitable to make the compositions more cosmetically or aesthetically acceptable or to provide additional use advantages thereto. Such conventional optional ingredients are known to those skilled in the art. This includes any cosmetically acceptable ingredients such as those listed in the CTFA International Cosmetic Ingredient Dictionary and Handbook, Rev. 7, Wenninger and McEwen, (The Cosmetic, Toiletry and Fragrance Association, Inc., Washington, DC, 1997). do. Some non-limiting examples of such optional components are given below.

Skin actives

It is highly desirable that the compositions of the present invention include a skin active agent. As used herein, the term "skin active agent" refers to any compound or mixture of compounds that provides, for example, moisture benefits, protection, skin feel, skin softness and / or skin smoothness benefits to the skin. Preferred skin benefit agents for use herein are wetting agents, emollients and mixtures thereof. Preferably the composition of the present invention comprises a humectant and an emollient.

Preferably the composition of the present invention comprises at least 1% by weight skin active agent. More preferably the composition comprises 2% to 70% by weight, preferably 5% to 60% by weight, even more preferably 10% to 55% by weight of the skin active agent.

Humectant

Very preferred optional ingredients for the compositions of the present invention are wetting agents. As used herein, the term "wetting agent" means a substance that provides a water-retaining benefit to the skin. Preferably, the composition of the present invention comprises at least 1% by weight, more preferably at least 5% by weight, even more preferably at least 10% by weight, even more preferably at least 20% by weight of wetting agent.

Any humectant suitable for use in the cosmetic composition can be used herein. Non-limiting examples of wetting agents suitable for use in the present invention are described in WO98 / 22085, WO98 / 18444 and WO97 / 01326. Preferably the humectant for use herein is selected from, but is not limited to: amino acids and derivatives thereof such as proline and arginine aspartate, 1,3-butylene glycol, propylene glycol and water and cordium tomentosaum (codium tomentosum) extracts, collagen amino acids or peptides, creatinine, diglycerol, biosaccharide gum-1, glucamine salts, glucuronates, glutamate salts, polyethylene glycol ethers of glycerin (e.g. glycereth 20), glycerin , Glycerol monopropoxylate, glycogen, hexylene glycol, honey, and extracts or derivatives thereof, hydrogenated starch hydrate, hydrolyzed mucopolysaccharides, inositol, keratin amino acids, urea, LAREX A-200 (commercially available from Larex), glycos Aminoglycans, methoxy PEG 10, methyl gluece-10 and -20 (both commercially available from Amerchol, Edison, NJ) , Methyl glucose, 3-methyl-1,3-butanediol, N-acetyl glucosamine salt, polyethylene glycol and derivatives thereof (e.g. PEG 15 butanediol, PEG 4, PEG 5 pentaerythritol, PEG 6, PEG 8, PEG 9), pentaerythritol, 1,2 pentanediol, PPG-1 glyceryl ether, PPG-9, 2-pyrrolidone-5-carboxylic acid and its salts such as glyceryl pca, saccharide isomerate (isomerate), SEACARE (available from Secma), sericin, silk amino acids, sodium acetylhyaluronate, sodium hyaluronate, sodium poly-aspartate, sodium polyglutamate, sorbeth 20, sorbeth 6, sugar and Sugar alcohols and derivatives thereof such as glucose, mannose and polyglycerol sorbitol, trehalose, triglycerol, trimetholpropane, tris (hydroxymethyl) amino methane salts, and yeast extracts, and mixtures thereof.

More preferably, the humectant for use herein is selected from glycerin, urea, butylene glycol, polyethylene glycol and derivatives thereof, or mixtures thereof. Even more preferably, the humectant for use herein is selected from glycerin, urea and mixtures thereof, in particular glycerine.

Softener

Another very preferred optional ingredient of the composition of the present invention is a softener. Softeners tend to lubricate the skin, increase the smoothness and softness of the skin, prevent or mitigate dryness of the skin and / or protect the skin. A wide variety of suitable softeners are known and can be used herein. Sagarin, Cosmetics, Science and Technology, 2nd Revision, Vol 1, pp. 32-43 (1972) include examples of numerous materials suitable for use as softeners. Preferably the composition of the invention comprises more than 1% by weight, more preferably at least 5% by weight, even more preferably at least 10% by weight of emollient.

Preferably the emollient for use herein is selected from:

i) C, straight and branched chain hydrocarbons having about 7 to about 40 carbon atoms, such as dodecane, squalane, mineral oil, cholesterol and derivatives thereof, hydrogenated polyisobutylene, isohexadecane and C ₇ -C ₄₀ branched hydrocarbons ₇ -C ₄₀ isoparaffin.

ii) C ₁ -C ₃₀ alcohol esters of C ₁ -C ₃₀ carboxylic acids and C ₂ -C ₃₀ dicarboxylic acids such as isononyl isononanoate, isopropyl myristate, myristyl propionate, isopropyl Stearate, behenyl behenate, dioctyl maleate, diisopropyl adipate, and diisopropyl dilinoleate.

iii) mono-, di- and tri-glycerides of C ₁ -C ₃₀ carboxylic acids and ethoxylated derivatives thereof. Suitable polyethylene glycol derivatives of glycerides include PEG-20 almond glycerides, PEG-60 almond glycerides, PEG-11 avocado glycerides, PEG-6 capric acid / caprylic acid glycerides, PEG-8 capric acid / caprylic acid glycerides, PEG-20 corn glycerides, PEG-60 corn glycerides, PEG-60 evening primrose glycerides, PEG-7 glyceryl cocoate, PEG-30 glyceryl cocoate, PEG-40 glyceryl cocoate, PEG-78 glyceryl cocoate, PEG-80 glyceryl cocoate, PEG-12 glyceryl dioleate, PEG-15 glyceryl isostearate, PEG-20 glyceryl isostearate, PEG-30 glyceryl isostearate, PEG-75 cocoa butter glycerides , PEG-20 hydrogenated palm oil glycerides, PEG-70 mango glycerides, PEG-13 mink glycerides, PEG-75 shorea butter glycerides, PEG-10 olive glycerides, PEG-12 palm fruit el) glycerides, PEG-45 palm fruit glycerides, PEG-8 glyceryl laurate and PEG-30 glyceryl laurate. Mixtures of polyethylene glycol derivatives of glycerides can also be used herein.

iv) alkylene glycol esters of C ₁ -C ₃₀ carboxylic acids, such as ethylene glycol mono- and di-esters, and propylene glycol mono- and di-esters of C ₁ -C _3O carboxylic acids, such as ethylene glycol distea Rate.

v) organopolysiloxane oils. The organopolysiloxane oil may be volatile, nonvolatile, or a mixture of volatile and nonvolatile silicones. As used herein, the term "nonvolatile" refers to silicone that is liquid under ambient conditions and has a flash point of about 100 ° C. or higher (under 1 atmosphere). As used herein, the term "volatile" refers to all other silicone oils. Suitable organopolysiloxanes can be selected from a variety of silicones, ranging from a wide range of volatility and viscosity. Nonvolatile polysiloxanes are preferred. Suitable silicone is U.S. Patent 5,069,897, issued December 3, 1991. Organopolysiloxanes selected from polyalkylsiloxanes, alkyl substituted dimethicones, dimethiconols, polyalkylaryl siloxanes, and mixtures thereof are preferred for use herein. Polyalkylsiloxanes and cyclomethicones are more preferred for use herein. Preference is given to dimethicone in polyalkylsiloxanes.

vi) vegetable oil and hydrogenated vegetable oil. Examples of vegetable oils and hydrogenated vegetable oils include safflower oil, castor oil, palm oil, cottonseed oil, menhaden oil, palm fruit oil, palm oil, peanut oil, soybean oil, rapeseed oil, linseed oil, rice bran oil, pine oil, sesame oil, Sunflower seed oils, partial and total hydrogenated oils from these sources, and mixtures thereof.

vii) animal fats and oils such as cod liver oil, lanolin and derivatives thereof such as acetylated lanolin and isopropyl lanoleate. Lanolin oil is preferred.

viii) C ₄ -C ₂₀ alkyl ethers of polypropylene glycol, C ₁ -C ₂₀ carboxylic acid esters of polypropylene glycol, and di-C ₈ -C ₃₀ alkyl ethers such as PPG-14 butyl ether, PPG-15 ste Aryl ethers, dioctyl ethers, dodecyl octyl ethers, and mixtures thereof are also useful.

ix) polyol carboxylic acid esters.

x) mixtures of the above.

Preferred emollients for use in the compositions herein include dodecane, squalane, cholesterol and derivatives thereof, isohexadecane, isononyl isononanoate, mineral oil, lanolin and derivatives thereof, safflower oil, castor oil, palm oil, cottonseed oil, palm Fruit oil, palm oil, peanut oil, soybean oil, polyol carboxylic acid esters and mixtures thereof. More preferred emollients for use herein are selected from polyol carboxylic acid esters, mineral oils and mixtures thereof.

The ester is derived from sugar or polyol moieties and one or more carboxylic acid moieties. Depending on the constituent acids and sugars, the esters may be in liquid or solid form at room temperature. Examples of liquid esters include: glucose tetraoleate, glucose tetraester of soybean oil fatty acid (unsaturated), mannose tetraester of mixed soybean oil fatty acid, galactose tetraester of oleic acid, arabinose tetraester of linoleic acid, xylose tetra Linoleate, galactose pentaoleate, sorbitol tetraoleate, sorbitol hexaester of unsaturated soybean oil fatty acid, xylitol pentaoleate, sucrose tetraoleate, sucrose pentaoleate, sucrose hexaoleate, sucrose heptaoleate Eights, sucrose octaoleate, and mixtures thereof. Examples of solid esters include: sorbitol hexaester, which is a palmitate and arachidate carboxylic acid ester addition in a 1: 2 molar ratio; Octaester of raffinose, which is a phenolic ester addition 1: linoleate and behenate in a 1: 3 molar ratio; Heptaester of maltose which is an esterified carboxylic acid addition 3: 4 molar ratio of sunflower seed oil fatty acid and lignocerate; Octaester of sucrose, which is an esterified carboxylic acid addition of 2: 6 molar ratio of oleate and behenate; And octaesters of sucrose which are esterified carboxylic acid additions in a 1: 3: 4 molar ratio of laurate, linoleate and behenate. Preferred solid materials are sucrose polyesters having a degree of esterification of 7-8 and C18 mono- and / or di-unsaturated and behenic with a molar ratio of fatty acid addition unsaturateds: behenic 1: 7 to 3: 5. Particularly preferred solid sugar polyesters are octaesters of sucrose, having about 7 behenic fatty acid moieties and about 1 oleic acid moiety in the molecule. Other substances include cottonseed oil or soybean oil fatty acid esters of sucrose. Ester materials are also described in U.S. Patent 2,831,854, U.S. Patent 4,005,196 (Jandacek, issued January 25, 1977); U.S. Patent 4,005,195 (Jandacek, issued January 25, 1977), U.S. Patent 5,306,516 to Letton et al., Issued April 26, 1994; U.S. Patent 5,306, 515 to Letton et al., Issued April 26, 1994; U.S. Patent 5,305,514 to Letton et al., Issued April 26, 1994; U.S. Patent 4,797,300 (Jandacek et al., Issued January 10, 1989); U.S. Patent 3,963,699 (Rizzi et al., Issued June 15, 1976); U.S. Patent 4,518,772 (Volpenhein, issued May 21, 1985); And U.S. Patent 4,517,360 (Volpenhein, issued May 21, 1985).

Polyol fatty acid polyesters suitable for use herein can be prepared by a variety of methods known to those skilled in the art. Such methods include: transesterification of polyols with methyl, ethyl or glycerol fatty acid esters using various catalysts; Acylation of polyols with fatty acid chlorides; Acylation of polyols with fatty acid anhydrides; And acylation of polyols using fatty acids themselves. For example, U.S. Patent number 2,831,854; U.S. See patent 4,005,196 (Jandacek, issued January 25, 1977).

Particularly preferred materials are known under the INCI name sucrose polycottonseedate.

Other skin effective agents

Other skin benefit agents may be useful in the compositions of the present invention. Examples of other skin active agents that can be used in the compositions include the following:

(a) vitamin compounds

In addition to those discussed above, the compositions may comprise vitamin compounds, precursors, and derivatives thereof. Such vitamin compounds may be in natural or synthetic form. Suitable vitamin compounds include vitamin A (e.g. beta carotene, retinoic acid, retinol, retinoid, retinyl palmitate, retinyl propionate, etc.), vitamin B (e.g. niacin, niacinamide, riboflavin, pantothenic acid, etc.), vitamin C (e.g. ascorbic acid, etc.), vitamin D (e.g. ergosterol, ergocalciferol, cholecalciferol, etc.), and vitamin K (e.g. phytonadione, menadione, pthiocol, etc.) have.

Preferred vitamin compounds for use in the compositions of the present invention are vitamin B ₃ compounds. Vitamin B ₃ compounds are particularly useful for regulating skin conditions as described in WO-A-97 / 39733. When present, the composition of the present invention is preferably from about 0.01% to about 50% by weight, more preferably from about 0.1% to about 10% by weight, even more preferably from about 0.5% to about 5% by weight. Contains vitamin B ₃ compounds.

As used herein, "vitamin B ₃ compound" means a compound having the formula:

[Wherein R is -CONH ₂ (ie niacinamide), -COOH (ie nicotinic acid) or -CH ₂ OH (ie nicotinyl alcohol); Derivatives thereof; And salts of any of the above.

Typical derivatives of the vitamin B ₃ compounds include nicotinic acid esters including non-vascular expanding esters of nicotinic acid, nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N-oxides and niacinamide N-oxides.

Examples of suitable vitamin B ₃ compounds are well known in the art and include Sigma Chemical Company (St. Louis, MO); ICN Biomedicals, Inc. (Urban, California) and Aldrich Chemical Company (Milwaukee, Wisconsin).

Vitamin compounds can be included as substantially pure substances, or as extracts obtained by appropriate physical and / or chemical isolation from natural (eg, plant) sources.

Other preferred vitamin compounds useful herein include tocopherol based antioxidants / radical scavengers. Preferred tocopherol based antioxidant / radical scavengers are selected from tocopherol (vitamin E), tocopherol acetate, tocopherol sorbate, other esters of tocopherol, and mixtures thereof. Preferably tocopherol acetate. For example, the use of tocopherol esters applicable to the present invention comprising tocopherol acetate in topical compositions is described in U.S. Pat. Patent 5,786,384.

Preferably the composition of the invention comprises from 0.1% to 10% by weight, more preferably from 0.1% to 5% by weight of a composition of antioxidant / radical scavengers based on tocopherols.

(b) anti-wrinkle and anti-skin atrophy actives

Examples of anti-wrinkle and anti-skin atrophy actives that can be used in the compositions of the present invention include lactic acid and its derivatives, retinoic acid and its derivatives (eg cis and trans); Retinol; Retinyl esters; Niacinamide, salicylic acid and derivatives thereof; Sulfur-containing D and L amino acids and derivatives and salts thereof, particularly N-acetyl derivatives, including but not limited to, preferred examples thereof include N-acetyl-L-cysteine; Thiols such as ethane thiol; Hydroxy acid, phytic acid, lipoic acid; Lysophosphatidic acid, and skin release agents (e.g., phenol and the like).

(c) antimicrobial and antifungal actives

Examples of antimicrobial and antifungal actives that may be used in the compositions of the invention include β-lactam drugs, quinolone drugs, ciprofloxacin, norfloxacin, tetracycline, erythromycin, amikacin, 2,4,4'-trichloro -2'-hydroxy diphenyl ether, 3,4,4'-trichlorocarvanide, phenoxyethanol, phenoxy propanol, phenoxyisopropanol, doxycycline, capreomycin, chlorhexidine, chlortetracycline, Oxytetracycline, clindamycin, ethambutol, hexamidine isethionate, metronidazole, pentamidine, gentamicin, kanamycin, linenemycin, metacycline, metheneamine, minocycline, neomycin, netylmycin, paromomycin, Streptomycin, tobramycin, myconazole, tetracycline hydrochloride, erythromycin, zinc erythromycin, erythromycin estholate, erythromycin Tearate, amikacin sulfate, doxycycline hydrochloride, capreomycin sulfate, chlorhexidine gluconate, chlorhexidine hydrochloride, chlortetracycline hydrochloride, oxytetracycline hydrochloride, clindamycin hydrochloride, ethambutol hydrochloride , Metronidazole hydrochloride, pentamidine hydrochloride, gentamicin sulfate, kanamycin sulfate, linenemycin hydrochloride, methacycline hydrochloride, metheneamine hypofurlate, metheneamine mandelate, minocycline hydrochloride, neomycin sulphate Pate, Netylmycin Sulfate, Paromomycin Sulfate, Streptomycin Sulfate, Tobramycin Sulfate, Myconazole Hydrochloride, Amanpadin Hydrochloride, Amanpadin Sulfate, Octopy Scotland, para-chloro-meta-xylenol, you statins, toll-naphthyl lactate, zinc pyrithione and clotrimazole but are included, and the like.

(d) sunscreen actives

The compositions herein may also contain sunscreen actives. A wide variety of sunscreen agents are useful herein. Such sunscreen agents include both organic compounds and salts thereof, as well as inorganic particulate materials. Without wishing to be bound by theory, it is believed that sunscreen agents provide protection from ultraviolet radiation by one or more mechanisms including absorption, dispersion and reflection of ultraviolet radiation. Non-limiting examples of such sunscreen agents are described in US Pat. No. 5,087,445 to Haffey et al., Feb. 11, 1992; U.S. Patent 5,073,372 (Turner et al., Issued Dec. 17, 1991); U.S. Patent 5,073,371 (Turner et al., Issued Dec. 17, 1991); US Patent No. 5,160,731 (Sabatelli et al., Issued Nov. 3, 1992); US Patent No. 5,138,089 to Sabatelli, issued August 11, 1992; U.S. Patent 5,041,282 (Sabatelli, issued August 20, 1991); U.S. Patent No. 4,999,186, issued to Sabatelli et al., March 12, 1991; US Patent No. 4,937,370 (Sabatelli, issued June 26, 1990); And in Segarin et al., Chapter VII, p. 189, Cosmetics Science and Technology . Preferred among the sunscreen agents are 2-ethylhexyl p-methoxycinnamate, octyl salicylate, octocrylene, oxybenzone, 2-ethylhexyl N, N-dimethylaminobenzoate, p-aminobenzoic acid, 2-phenyl -Benzimidazole-5-sulfonic acid, homomentyl salicylate, DEA p-methoxycinnamate, 4,4'-methoxy- t -butyldibenzoylmethane, 4-isopropyldibenzoylmethane, 3- (4 -Methylbenzylidene) camphor, 3-benzylidene camphor, 4-N, N-dimethylaminobenzoic acid ester with 2,4-dihydroxybenzophenone, 2-hydroxy-4- (2-hydroxye 4-N, N-dimethylaminobenzoic acid ester with oxy) benzophenone, 4-N, N-dimethylaminobenzoic acid ester with 4-hydroxydibenzoyl-methane, 4- (2-hydroxyethoxy) dibenzoyl 4-N, N-dimethylaminobenzoic acid ester with methane, 4-N, N-di (2-ethylhexyl) aminobenzoic acid ester with 2,4-dihydroxybenzophenone, 2-hydroxy-4- ( 2-hydroxyethoxy) benzo 4-N, N-di (2-ethylhexyl) aminobenzoic acid ester with phenone, 4-N, N-di (2-ethylhexyl) aminobenzoic acid ester with 4-hydroxydibenzoylmethane, 4- (2 4-N, N-di (2-ethylhexyl) aminobenzoic acid ester with -hydroxyethoxy) dibenzoylmethane, 4-N, N- (2-ethylhexyl with 2,4-dihydroxybenzophenone ) Methylaminobenzoic acid ester, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester with 2-hydroxy-4- (2-hydroxyethoxy) benzophenone, and 4-hydroxydibenzoylmethane 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester, 4-N, N- (2-ethylhexyl) methylaminobenzoic acid ester with 4- (2-hydroxyethoxy) dimenzoylmethane , Titanium dioxide, zinc oxide, iron oxide, and mixtures thereof.

More preferred for use in the compositions described herein are 2-ethylhexyl N, N-dimethyl-p-aminobenzoate, 2-ethylhexyl p-methoxycinnamate, octocrylene, octyl salicylate, homomentyl salicylate Silates, p-aminobenzoic acid, oxybenzone, 2-phenylbenzimidazole-5-sulfonic acid, DEA p-methoxycinnamate, 4,4'-methoxy- t -butyldibenzoylmethane, 4-isopropyl di 4-N, N- (2-ethylhexyl) methyl with benzoyl methane, 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor, 4- (2-hydroxyethoxy) dibenzoylmethane Sunscreen agents selected from the group consisting of aminobenzoic acid esters, titanium dioxide, zinc oxide, iron oxide, and mixtures thereof.

The exact amount of sunscreen that can be used will depend on the sunscreen chosen and the desired Sun Protection Factor (SPF) to be achieved. SPF is a commonly used measure of photoprotection of sunscreens against erythema. Federal Register , Vol. 43, No. 166, pp. 38206-38269, August 25, 1978].

Polar solvent

The composition of the present invention should also contain a polar solvent. Any polar solvent suitable for use in the cosmetic composition can be used herein. However, the polar solvent must be polar enough to cause the formation of vesicles in the present invention. Preferably, the polar solvent used in the composition of the present invention is water.

Preferably, the composition will contain 10% to 90% by weight, more preferably 20% to 80% by weight, even more preferably 30% to 60% by weight of a polar solvent.

Thickener

The composition of the present invention preferably contains a thickener. Any thickener suitable for use in the cosmetic composition can be used herein. Preferred thickeners are selected from nonionic water soluble polymers, fatty alcohols and mixtures thereof. Suitable nonionic polymers include cellulose ethers (e.g., hydroxybutyl methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, ethyl hydroxy ethyl cellulose, hydrophobically modified hydroxyethyl cellulose and hydroxyethyl cellulose). Such water-soluble polymers, poly (ethylene oxide), polyvinyl alcohol, polyvinylpyrrolidone, hydroxypropyl guar gum, amylose, hydroxyethyl amylose, starch and starch derivatives. Suitable fatty alcohols are high molecular weight, nonvolatile, primary alcohols having the formula:

RCH ₂ OH

_Wherein R is C _8-20 alkyl.

They can be prepared from natural fats or oils by reduction of fatty acid COOH-groups to hydroxyl functionality. Alternatively, fatty alcohols of the same or similar structure may be prepared according to conventional synthesis methods known in the art. Suitable fatty alcohols include behenyl alcohol, C ₉ -C ₁₁ alcohol, C ₁₂ -C ₁₃ alcohol, C ₁₂ -C ₁₅ alcohol, C ₁₂ -C ₁₆ alcohol, C ₁₄ -C ₁₅ alcohol, caprylic alcohol, cetea Contains ryl alcohol, coconut alcohol, decyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, oleyl alcohol, palm fruit alcohol, stearyl alcohol, cetyl alcohol, tallow alcohol, tridecyl alcohol or myristyl alcohol However, it is not limited to this.

Other optional ingredients

The composition of the present invention may contain a wide variety of other optional ingredients. The additional ingredient should be pharmaceutically acceptable. Non-limiting examples of functional groups suitable for use in the compositions of the present invention include: abrasives, absorbents, anti-acne actives, anti-cake forming agents, antidandruff agents, antiperspirants, antioxidants, anti-viral active agents, Artificial tanning actives and accelerators, biological additives, bleaching agents, bleaching agents, brighteners, builders, buffers, chelating agents, chemical additives, colorants, cosmetics, cleansers, cosmetic astringents, cosmetic biocides, denaturants, Deodorants, epidermal deactivators, depilators, drug astringents, dyes, dye transfer agents, enzymes, external anesthetics, foam generators, flavoring agents, membrane formers, fragrance components, insect repellents, flavoring agents, nonsteroidal anti-inflammatory agents, opacifying agents, Oxidizing dyes, oxidizing agents, pest control ingredients, pH adjusting agents such as citric acid, pH buffers, pharmaceutical actives, plasticizers, preservatives, radical scavengers, skin, hair Fish or toenail bleach, skin, hair or toenail conditioner, skin, hair or toenail penetration enhancer, stabilizer, surfactant, surface conditioner, reducing agent, temperature lowering agent, viscosity modifier, and warmer, eg Exothermic zeolite. Also useful herein are aesthetic components such as colorants, essential oils, and skin healing agents. Other optional materials herein include pigments. Pigments suitable for use in the compositions of the present invention may be organic and / or inorganic. The term also includes pigments having low coloration or gloss, such as matte finishes, and also light scattering agents. Examples of suitable pigments are iron oxide, acylglutamate iron oxide, titanium dioxide, ultramarine blue, D & C dyes, carmine, and mixtures thereof.

Formulation Method

Preferably the composition of the present invention is prepared in such a way that the quaternary ammonium compound forms an endoplasmic reticulum. The endoplasmic reticulum also preferably contains a humectant. Preferably the endoplasmic reticulum also contains a softener. Even more preferably the endoplasmic reticulum comprises pantothenic acid or pantothenic acid derivatives. In order to ensure the optimum performance properties, it is preferred that the composition of the present invention is prepared as follows:

(Iii) mix all or part of the quaternary ammonium preparation with a wetting agent, pantothenic acid or pantothenic acid derivative, a water soluble skin care active agent (if included), and preferably at a temperature above the melting point of the polar solvent and the quaternary ammonium preparation;

(Ii) optionally, stirring the mixture vigorously;

(Iii) preparing an emulsion in a separation vessel as follows;

(iv) Oil phase containing emollients, where thickeners are useful, suitable thickeners, and any remaining quaternary ammonium formulations are mixed together at a temperature above the melting point of the quaternary ammonium compound. The aqueous phase is prepared separately. If water, the thickener is water soluble, the appropriate thickener and any remaining water soluble components are heated to the same temperature as the oil phase.

(v) Subsequently, the temperature of the aqueous phase of the oil and the emulsion is made approximately equal, and the aqueous phase is combined with the oil phase under stirring.

(vi) In the preparation of the emulsion, the mixture formed in step (iii) is added to the abovementioned emulsion with stirring.

How to use

The cosmetic composition of the present invention can be used in a conventional manner for skin treatments. An effective amount of the composition, typically from about 0.1 g to about 50 g, preferably from about 1 g to about 20 g, is applied to wet or dry, preferably wet skin. Application of the composition typically includes application of the composition to the skin, typically the hands and fingers. The composition is then left on the skin, or preferably the skin is rinsed.

Thus, a preferred treatment method for the skin comprises the following steps:

(a) applying an effective amount of the cosmetic composition to the skin,

(b) Rinse the skin.

Preferred embodiments of the present invention include the above method of applying the composition to dry skin prior to application to wet skin. Thus, preferred methods include the following:

(Iii) applying an effective amount of the cosmetic composition to the dry skin;

(Ii) rinse the skin under the shower;

(Iii) further applying the composition;

(Iii) Rinse again.

Most of the damage to human skin is due to repeated exposure to the surfactant containing the composition during the washing procedure. It has been found that such damage can be alleviated using the present compositions. Thus, another preferred method includes the following:

(Iii) washing the skin with a composition containing a surfactant;

(Ii) rinse the skin;

(Iii) applying the composition according to the invention to wet skin;

(Iii) Rinse the skin.

It has also been found that the compositions are particularly useful when included as part of a regular route. Thus, another preferred method includes the following:

(Iii) applying to the skin a composition comprising:

(a) at least one quaternary ammonium compound;

(b) wetting agents;

(Ii) rinse the skin;

(Iii) repeat steps (iii) and (ii) within 48 hours.

The compositions also include damage due to skin exposure to ultraviolet radiation, damage due to skin exposure to water during swimming or similar water based exercises, damage due to shaving or exfoliation or skin exposure to water during bathing. It can be useful to mitigate damage.

The following examples further illustrate preferred embodiments within the scope of the present invention. The examples are provided for illustrative purposes only and many modifications of the invention are possible without departing from the spirit or scope thereof and should not be construed as limiting the invention. Unless otherwise indicated, all ingredients are in percent by weight of active ingredient.

1: Croda commercially available

2: Floratech, Arizona, USA

3: Hoffman La Roche, New Jersey, USA

4: Amerchol, NJ, USA

5: Rhodia, New Jersey, USA

In Examples 1, 4, 7, 9, 17, 20, 22, 24, 28, 36, 38, 47, 49, 53 and 56, the quaternary ammonium compounds used were supplied by Goldschmidt under the trade name Varisoft TA100. Distearyl dimethyl ammonium chloride.

Example 2, 3, 5, 6, 8, 10, 15, 16, 18, 19, 21, 23, 26, 27, 31, 33, 34, 35, 37, 41, 45, 46, 48, 50 , 51, 52, 54, 55, the quaternary ammonium compounds used are N, N-di (canolyl-oxy-ethyl) -N methyl, N- (2-hydride, supplied under the trade name Rewoquat V3620 by Goldschmidt. Oxyethyl) ammonium methyl sulfate.

In Example 11, the quaternary ammonium compound used is N, N-di (canolyl-oxy-ethyl) -N methyl, N- (2-hydroxyethyl) ammonium supplied by Goldschmidt under the trade name Rewoquat WE18. Methyl sulfate.

In Example 12, the quaternary ammonium compound used was N, N-di (canolyl-oxy-ethyl) -N methyl, N- (2-hydroxyethyl), supplied to the developing material (WE25) by Goldschmidt. Ammonium chloride.

In Example 13, the quaternary ammonium compound used is methylbis (hydrogenated tallowamidoethyl) (2-hydroxyethyl) ammonium methyl sulfate, supplied under the trade name Varisoft 110 by Goldschmidt.

In Example 14, the quaternary ammonium compound used is methylbis (tallowamidoethyl) (2-hydroxyethyl) ammonium methyl sulfate, supplied under the trade name Varisoft 222 by Goldschmidt.

In Example 25, the quaternary ammonium compound used is methyl-1-tallowoilethyl-2-tallowimidazoline, which is a developing material supplied by Goldschmidt.

In Example 29, the quaternary ammonium compound used is methyl-1-tallowamidoethyl-2-tallowimidazoline, which is a developing material supplied by Goldschmidt.

In Example 30, the quaternary ammonium compound used is methyl-1-tallowoilethyl-2-tallowimidazolinium methyl sulphate supplied by Goldschmidt.

In Example 32, the quaternary ammonium compound used is methyl-1-tallowamidoethyl-2-tallowimidazolinium methyl sulfate supplied by Goldschmidt under the trade names Varisoft 475, Varisoft 445.

In Example 39, the quaternary ammonium compound used is N, N-dimethyl-N- (canolyl-oxy-ethyl) -N- (canolamidoethyl) amine supplied by Kao.

In Example 40, the quaternary ammonium compound used is N, N-dimethyl-N- (canolyl-oxy-ethyl) -N- (canolamidoethyl) ammonium methyl sulfate supplied by Kao.

In Example 42, the quaternary ammonium compound to be used is N, N'-bis (2-taloyloxyethyl) -N, N, N, disclosed in Ciba-Geigy Corporation Patent US 4728337, US 4721512, US 4906413. ', N'-tetramethylene diammonium dichloride.

In Example 43, the quaternary ammonium compounds used are N, N'-bis (2-canolyloxyethyl) -N, N-dimethyl-N, N, disclosed in Goldschmidt-Witco patents EP 0503155A1 and EP 0803498. '-(2-hydroxyethyl) -1,6-hexane diammonium methyl sulfate.

In Example 44, the quaternary ammonium compounds used are quaternized following the reaction of fatty acids, these functional (or multifunctional) acids and triethanolamines, as described in WO98 / 49132 by Kao and US 5880289 by Henkel. Di and oligo ester quaternaries prepared.

fair

In an embodiment comprising component C:

1. Premix 1: Mix the components of group A together at a temperature higher than the transition temperature of the selected quaternary ammonium compound, leaving a predetermined portion of the quaternary ammonium compound and water. The premix is stirred vigorously.

2. Premix 2: Combine the components of groups B and C with some of the remaining quaternary ammonium compound and water not previously used in premix 1. Heat above the melting point of the quaternary and oil.

3. Combine premixes 1 and 2, cool to 40 ° C. and stir in perfume.

In an embodiment comprising component D:

1. Premix 1: Combine the components of group A together at a temperature higher than the transition temperature of the selected quaternary ammonium compound and leave a predetermined portion of water. The premix is stirred vigorously.

2. Premix 2: Combine the components of group D with water which was not used previously in premix 1 with stirring.

3. Combine the premixes 1 and 2 and the components of groups B and E. Stir vigorously.

The compositions of this embodiment have good skin care benefits, such as good moisturization, good hydration, good skin feel, good skin softness and / or good skin smoothness, low levels of negative aspects such as slippery, sticky or tacky. Provided by.

Claims (10)

Cosmetic compositions comprising: (a) one or more quaternary ammonium preparations; And (b) more than 0.5% pantothenic acid or pantothenic acid derivatives and mixtures thereof. The composition of claim 1 wherein the pantothenic acid or pantothenic acid derivative is selected from panthenol and mixtures thereof. The composition of claim 1 or 2, further comprising an antioxidant / radical scavenger based on tocopherol. The composition of claim 1, further comprising a vitamin B ₃ compound. The composition of any one of claims 1 to 4, further comprising a skin benefit agent. The composition according to any one of claims 1 to 5, further comprising a skin active agent selected from wetting agents, emollients and mixtures thereof. The composition according to any one of claims 1 to 6, wherein the quaternary ammonium preparation is selected from those according to formula II or III: [Formula II] [Formula III] [Wherein each R ₅ unit is hydrogen, branched or linear chain C ₁ -C ₆ alkyl, branched or linear chain C ₁ -C ₆ hydroxyalkyl and mixtures thereof, preferably methyl and hydroxyethyl Independently selected from; Each R ₆ unit is independently linear or branched C ₁₁ -C ₂₂ alkyl, linear or branched C ₁₁ -C ₂₂ alkenyl, and mixtures thereof; X ⁻ is an anion that is compatible with the skin care active agent and additional ingredients; m is 1 to 4, preferably 2; n is 1 to 4, preferably 2 and Q is a carbonyl unit selected from: (Wherein R ₇ is hydrogen, C ₁ -C ₄ alkyl, C ₁ -C ₄ hydroxyalkyl, and mixtures thereof). The composition of claim 1, wherein the composition comprises an endoplasmic reticulum, wherein the vesicle comprises a quaternary ammonium preparation and a pantothenic acid or pantothenic acid derivative. 9. A composition according to any one of the preceding claims comprising less than 5% by weight, preferably less than 3% by weight, preferably 0% by weight of anionic surfactant. Use of a composition according to any of claims 1 to 9 for the treatment of skin.