KR20020018554A - Coating composition containing chromium picolinate, manufactoring method of same, and using of same - Google Patents

Abstract

PURPOSE: A coating agent containing chromium picolinate, its preparation method and the use are provided. It is used in the food for prevention of various diseases and making a diet or a diabetic food. The above coating agent is claimed to increase the sensitivity of insulin and act as glucose tolerance factor to the type 2 diabetic patient. The coating agent dries fast saving time and gives smooth surfaced of the coated food. The foods being coated are mainly candy tablet and chewing gum. CONSTITUTION: The steps of making above coating agent comprise: mixing 80-90wt.% of isomalt, 5-15wt.% of chromium picolinate and 1-10wt.% of maltitol solution, making a paste phase, granules and powders to prepare a preparatory composition; mixing the above composition with sorbitol and maltitol solution to make granules being 20-60 mesh and tableting to make the core composition; making a gum composition by sub-coating to the above core with the mixture 30-35wt.% of isomalt, 1-7wt.% of arabic gum and 40-45wt.% of water; repeated coating and drying by the mixture of 55-65wt.% of isomalt, 1-7wt.% of arabic gum, 0.05-1wt.% of titanium dioxide and 40-45wt.% of water; coating by the mixture of 55-65wt.% of isomalt, 1-7wt.% of arabic gum, 1-5wt.% of maltitol solution and 30-40wt.% of water; and coating a layer by hydroxypropyl methylcullulose.

Description

Coating agent containing chromium picolinate, manufacturing method and use thereof {COATING COMPOSITION CONTAINING CHROMIUM PICOLINATE, MANUFACTORING METHOD OF SAME, AND USING OF SAME}

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a coating agent containing chromium picolinate, a method for producing the same, and a use thereof, wherein picoline, which is useful for preventing and treating various diseases, and as a diabetic or diabetic plant by effectively adding trivalent picolinate to candy and the like. A coating composition containing acid chromium, a method for preparing the same, and a use thereof.

Hard coating forms a very hard coating layer in which the crystalline material of the concentrate is made up of fine particles. Sugar coating forms a hard coating layer of crystalline material having a particle size of 5 μm or less, and sorbitol coating is a particle size of the particle. It is large enough to form a very rough coating layer.

Korean Patent Publication No. 95-4568 describes a carbon dioxide gas-containing candy and a method of preparing the same, wherein the candy is coated with chocolate on the surface of the candy in which carbon dioxide gas is released to the outside even when a slight temperature is applied.

Korean Patent Publication No. 82-915 describes a method for preparing barley choco sneck, which is coated with chocolate solution at 40 ° C. on puffed barley, and then put chocolate flakes and second coating by applying hot air at 60-70 ° C. ,

Republic of Korea Patent Publication No. 99-22713 describes a non-dry coating method for the coated foods by spraying the sweetener solution to the heated food coating,

Republic of Korea Patent Publication No. 1992-9379 describes a coating device consisting of a vacuum tube and a reaction tank,

Korean Patent Publication No. 1986-1118 describes a maltodextrin coating.

In the conventional technique, the surface of the coating layer dries rapidly during drying, but the coating layer near the core dries slowly, so that moisture in the core leaves the exterior with the water-soluble pigment while leaving the exterior while storing the product. If the coating layer is dried too quickly, the concentration of the syrup increases and the surface dries quickly, but drying of the internal moisture prevents the formation of a skin of rubbery fluid that inhibits the rate of crystallization. There has been a problem that prevents drying.

The present invention to solve the above problems, the present invention in the preparation of coated foods containing chromic picolinate (tablet candy and chewing gum), chromium in the form of a trivalent salt of picolinate is mixed with food, It is an object of the present invention to provide a coating containing chromic picolinate, which is coated so that its components are stable in the product.

It is also an object of the present invention to provide a method for producing a coated food containing chromium picolinate.

It is another object of the present invention to provide a coated food composition having a smooth surface and a hard coating layer.

In order to achieve the above object, the present invention is characterized in that the present invention comprises 80 to 90% by weight of isomalt powder, 5 to 15% by weight chromium picolinate and 1 to 10% by weight maltitol solution It provides a coating composition comprising chromium.

In addition, the present invention is a method for producing a coating agent containing chromium picolate, 80 to 90% by weight of isomalt powder, 5 to 15% by weight of chromium picolate and 1 to 10% by weight of the maltitol solution by mixing on a blender It is prepared in a paste (paste), and the granules of the paste and then pulverized to provide a coating production method characterized in that the particle size of the powder is prepared to be less than 180 mesh.

In another aspect, the present invention (a) a picolinate chromium composition preparation step of mixing, granulating and powdering isomalt, chromium picolinate and maltitol solution;

(b) (i) mixing the picolinate chromium composition and sorbitol;

(ii) granulating by mixing maltitol solution in the mixture;

(iii) drying the granulate to size 20 to 60 mesh; And

(iv) tableting the granules;

Preparing a core;

(c) a saponification step of sub-coating the core with a mixture comprising 30 to 35 wt% isomalt, 23 to 27 wt% arabic gum and 40 to 45 wt% water;

(d) spraying and drying the core with a mixture comprising 55-65 wt% isomalt, 1-7 wt% arabic gum, 0.05-1 wt% titanium dioxide, and 30-40 wt% water Coating step to repeat;

(c) a finish coating step of coating with a mixture comprising 55 to 65 wt% isomalt, 1 to 7 wt% gum arabic, 1 to 5 wt% maltitol solution and 30 to 40 wt% water, and

(d) photocoating with hydroxypropylmethylcellulose

It provides a coating method comprising a coating.

In addition, the present invention

(a) preparing a picolinate chromium composition for mixing, granulating and powdering isomalt, chromium picolinate and maltitol solution;

(b) (i) mixing the picolinate chromium composition and sorbitol;

(ii) granulating by mixing maltitol solution in the mixture;

(iii) drying the granulate to size 20 to 60 mesh; And

(iv) tableting the granules; Preparing a core;

(c) a saponification step of sub-coating the core with a mixture comprising 30 to 35 wt% isomalt, 23 to 27 wt% arabic gum and 40 to 45 wt% water; And

(d) providing a coating method comprising a film coating step of repeatedly spraying and drying a mixture comprising 75 to 89% by weight of water and 15 to 25% by weight of hydroxypropyl methylcellulose in a core. do.

In another aspect, the present invention provides a tableting candy or chewing gum containing chromium picolinate prepared by the above method.

Hereinafter, the present invention will be described in detail.

Chromium was identified by Schwarz K. and Mertz W. Arch in 1957 as a Glucose Tolerance Factor (GTF) needed to restore normal glucose tolerance in rats and was found to be an essential trace element that enhances insulin action. lost. Glucose resistance factors play an important role in insulin binding to insulin receptors in cell membranes to enhance insulin functionality and activate energy metabolism.

In addition, picolinate chromium complexed with picolinic acid was found to not only maximize insulin action in the body but also increase muscle synthesis. Insulin resistance is also a phenomenon of chromium deficiency, in which insulin can be efficiently used as an energy source by increasing insulin action by administering an appropriate amount of physiologically active form of chromium. Insulin resistance has been known as an aging process that progresses with age, but obesity constitution often indicates insulin resistance and also develops adult diabetes.

Compared with chromium (Cr ³⁺ ), chromium picolinate is known to have high bioavailability, act on carbohydrates and lipid metabolism, improve blood fat status, and help blood sugar, body fat, appetite and osteoporosis. In addition, the amount of chromium in the body decreases with aging, and it is known that the amount of chromium that can be consumed as a food is very small and its solubility is so low that it is absorbed in the body. The recommended chromium intake for adults is 50-200 ugs per day (The National Food Research Council, National Academy of Science, 1980), and in the US FDA in December 1995, the 120 ug Daily Intake for all people age 7 and older. ).

The present invention relates to a coating agent containing chromium picolinate having high bioavailability and excellent effect.

The coating agent of the present invention comprises 80 to 90% by weight of isomalt powder, 5 to 15% by weight of chromium picolinate and 1 to 10% by weight of maltitol (80%) solution.

In the method for preparing a coating agent of the present invention, 80 to 90% by weight of isomalt powder, 5 to 15% by weight of chromium picolinate, and 1 to 10% by weight of maltitol solution (80% DS) are mixed on a blender to form a paste phase. It is characterized in that the paste is granulated into a powder and then pulverized to prepare a particle size of the powder to 180 mesh or less.

The isomalt (trade name paratinite) is a sugar alcohol reduced by palatinose, an isosaccharide of sucrose, and does not induce fermentation by oral microorganisms (S. Mutans) when ingested. I never do that. The calorie content of isomalt is less than 2 kcal / g (FDA regulation) compared to the calorie content of sugar 4 kcal / g, which is suitable as a raw material for diet or diabetic foods. The sweetness of isomalt is similar to sugar but the sweetness is 0.45 of sugar. It is about 0.60 times. In addition, isomalt does not increase blood sugar in the body, thereby stimulating insulin secretion, and does not cause insulin deficiency in diabetics. In addition, isomalt has low hygroscopicity, which is stable in product quality, and absorbs up to about 8% of moisture to maintain the crispness or crunchiness of the product.

The present invention also provides a coating method for coating.

The coating method is to prepare a core and then coated with a coating composition. The core composition comprises 1 to 40% by weight of chromic picolinate composition, 20 to 80% by weight of sorbitol, 10 to 40% by weight of maltitol solution, and 50 to 200 parts by weight of isomalt, relative to the core composition. From 200 to 200 parts by weight gum base, 40 to 120 parts by weight of L-carnitine L-tartrate, 25 to 100 parts by weight of xylitol, 0.5 to 5 parts by weight of magnesium stearate and 1 to 6 parts by weight of vitamin C It further includes one or more selected.

The coating composition comprises 55 to 65% by weight of isomalt, 2 to 5% by weight of gum gum 0.5 to 1% by weight of maltitol solution, 0.1 to 5% by weight of titanium dioxide and 30 to 40% by weight of water.

Another coating composition of the present invention is 20 to 30% by weight of isomalt, 70 to 80% by weight of water, 15 to 22% by weight of hydroxypropyl methylcellulose (hereinafter referred to as 'HPMC') and 0.05 to 1 weight percent pigment.

The coated food manufacturing method of the present invention includes a method of preparing the core and then coating. The coated food is preferably to vary the production method according to the type of food, shown below a tableting candy manufacturing method and a chewing gum manufacturing method.

[Manufacturing Method I]

1.Preparation of picolinate chromium composition: Mix and powder sorbitol, chromium picolinate and maltitol solution.

2. Coase preparation step: Mixing (Picolate acid chromium composition, sorbitol, isomalt)-> Granules (with maltitol solution)-> Drying-> Mixing (with magnesium stearate)-> Tableting

3. Coating step: safflower-> coating-> finishing

4. Polishing step: Polishing process is performed with a polishing agent.

The picolinate chromium composition preparation step is a mixture of 80 to 90% by weight of isomalt powder, 5 to 20% by weight of chromium picolate and 1 to 10% by weight of maltitol (80%) solution, granulation process, powder Process.

The coazo step comprises the steps of (a) mixing 1 to 40% by weight of chromium picolinate composition and 20 to 80% by weight of sorbitol, and (b) mixing 10 to 40% by weight of maltitol solution to the mixture to obtain granules. (C) drying the granules, sizing them to 20 to 60 mesh, and (d) tableting the granules. In addition, 50 to 200 parts by weight of isomalt, 50 to 200 parts by weight of gum base, 40 to 120 parts by weight of L-carnitine L-tartrate, 25 to 100 parts by weight of xylitol, 0.5 to 5 parts by weight of the core composition. It further comprises one or more selected from the group consisting of magnesium stearate and 1 to 6 parts by weight of vitamin C.

The coating step is to coat the prepared core with a composition comprising isomalt, gum arabic, it characterized in that it comprises three steps (gumhwa-> coating-> finishing).

Saponification is sub-coating the core with a mixture comprising 30 to 35% by weight isomalt, 23 to 27% by weight gum arabic and 40 to 45% by weight water. The saponification step is preferably carried out in a conventional coating pan.

The coating comprises spraying and drying the core with a mixture comprising 55-65 wt% isomalt, 1-7 wt% arabic gum, 0.05-1 wt% titanium dioxide, and 30-40 wt% water. It is preferable to repeat.

Finishing is carried out to remove irregular coating and roughness of the core surface, 55-65 wt% isomalt, 1-7 wt% arabic gum, 1-5 wt% maltitol solution (maltitol: water = 80- 83: 17-20) and 30 to 40% by weight of water is preferred.

In the photocoating step, it is preferable to carry out the photocoating process by coating the film while spraying HPMC on the coated coating agent.

[Manufacturing Method II]

1.Preparation of picolinate chromium composition: Mix and powder sorbitol, chromium picolinate and maltitol solution.

2. Coase preparation step: mixing (chromic picolinate composition, sorbitol, xylitol, L-carnitine)-> granules (with maltitol solution)-> drying-> mixing (with magnesium stearate)-> tableting

3. Coating step: safflower-> membrane coating

The preparation method II is the same as the preparation method I, but in the film coating, the composition and the process is different. The membrane coating in Preparation Method II comprises 75 to 89% by weight of water, 15 to 25% by weight of HPMC and 0.05 to 0.5% by weight of pigment.

The coating composition is sprayed on the core in a rotating pan. Therefore, the coating composition should be added in an amount sufficient to sufficiently cover the surface of the core, have a constant viscosity, and should be able to dry form a smooth film. The coating composition applied to the core surface is concentrated by the dried air and recrystallized to form a coating layer. In general, the coating composition is dried and recrystallized at the same time. The quality of is determined. The coating composition is concentrated upon contact with cores, resulting in recrystallization, resulting in supersaturation, crystal nuclei, and nuclei growing to determine crystal size. That is, the coating composition controls the ratio of nucleation and nucleus growth to give the food the characteristics of the coating layer is hard and crunch (crunch).

In addition, for drying the coating composition of the core surface, the coating pan preferably has a higher water vapor pressure than the surrounding air, and it is preferable to maintain the relative humidity of the ambient below a certain level. At this time, the drying mechanism may be represented as a process of transferring moisture inside the coating layer and transfer of the transfer material into the air outside the coating layer.

The drying rate during the panning process of the fan is controlled by various factors.The temperature, syrup sugar, etc. affect the internal diffusion, and the relative humidity of the dry air, the temperature of the air, and the air flow rate are influenced by the external diffusion. Affect Molecular motion decreases with increasing concentration and increases with increasing temperature, so the fastest drying method during panning is the maintenance of low and high temperatures. Nucleation of the coating layer is produced by heterogeneous nucleation mechanisms by an external seeding agent. Since nucleation is increased by friction during the rotation of the core, when the syrup is added when the crystal powder is produced, the injected syrup causes recrystallization. At this time, if dried quickly, the concentration of syrup proceeds quickly, and a rubbery fluid film is formed. A rubbery fluid membrane suppresses the water transition of the syrup, thereby suppressing the rate of crystallization.

The quality of a coated product is affected by many factors that affect the coating. Application cycle time, temperature of both dry and fan, syrupconcentration, relative humidity and velocity of the air, and syrup The quality of the coated product is determined by its purity, impurity or additive to the syrup, and the coverage of sugar dust seeds in the pan.

If the temperature inside the fan or the temperature in the drying air rises, the driving force increases, which greatly affects the drying and crystallization of the syrup. As the temperature rises, the relative humidity in the air is lowered and the molecular movement is increased to promote the rate of water movement inside the core and the evaporation of water on the surface of the coating layer. Therefore, high temperature supply during the coating process is the most effective way to promote drying and crystallization.

On the other hand, if a small amount of water is present in the high concentration coating syrup and the viscosity is high, it takes a long time to remove the water in the syrup by limiting the movement of water molecules on the core surface. In addition, since a high concentration of the coating syrup creates a high concentration of supersaturation and has a high viscosity, the crystallization of the coating syrup is practically time-consuming. In the results of the present invention, the recrystallization growth rate was decreased in the solid content of the coating syrup ranged from 70 to 76% (w / w).

Theoretically, the increase in the relative humidity of dry air increases the vapor pressure in the air, as shown in Equation 1, which reduces the driving force of the coating syrup. However, in the experiments of the present invention, it was found that the relative humidity of the air around the fan induces crystallization of the syrup, which is slowly dried and recrystallized in the initial coating process, but does not directly affect the coating process. This means that the change in relative humidity of air has no significant effect on drying or growth rate of crystal grains. On the other hand, the flow rate of the blow dry air removes moisture on the surface of the core, but the present invention did not directly affect the recrystallization process.

[Calculation 1]

m = kd (Pws-Pwa)

m: mass transfer rate at which moisture is transferred into the air

kd: mass convective transfer coefficient

Pws: Water vapor pressure on the dry surface

Pwa: Water vapor pressure in the air

In addition, the effects on the coating process are: pan tumbling speed, pan geometry, side verse top venting of air, purity of the coating syrup, and additives of the coating syrup. Types and quantities. These factors have a great influence on the proportion of the recrystallized particles, especially in the present invention, when a certain amount of the scar pigment (lake) pigment is delayed by about 50% growth rate of the crystal grains of the syrup, even when the starch syrup or reducing sugar is added It was confirmed that the growth rate is delayed.

In the present invention, the wider the bottom of the pan is, the better the ventilation on the left and right sides of the top of the pan (the greater the Velosity), the higher the coating syrup concentration is, the better the coating is, and the less the kind of additives of the coating syrup and the greater the recrystallization ability of the additives The coating went well.

The chromium salt contained in food is prepared by the method of synthesizing chromium trivalent salt, and chromium picolinate or trivalent chromium salt may be used, and the content of the chromium salt is 0.001 to 0.8 wt% in the final product. This is preferable. Since the amount of chromium picolinate to be contained in the food is very small, the preparation and use of the mixed phycocholine chromium composition of chromium picolinate and sorbitol, as in the present invention, not only saves manufacturing time at the time of manufacture, It can also be accurate in the weighing of trace materials such as chromium picolate.

The present invention also provides a coated food. The coated food is prepared by coating the coating of the present invention is preferably a tableting candy or chewing gum. Chewing gum can be prepared by mixing the gum base during the preparation of the coa preparation, and performing the same method as the coating method described above after the extrusion process. The manufacturing process diagram of the present invention can be summarized as follows.

[Production process of coated candy]

Mixing → Granules → Granules → Mixing → Tableting → Coating (Gumming → Coating → Polishing) → Packing

[Manufacturing process of coated chewing gum]

Mixing of raw materials → 1st extrusion → 1st cooling → 2nd extrusion → Rolling → Forming → Cooling → Aging → Coating (Gumming → Coating → Polishing) → Packing

The coated food of the present invention includes chromium picolinate, which increases the insulin sensitivity and glucose tolerance in type 2 diabetes (acts as a glucose tolerance factor) and saturated fatty acids. In addition to reducing the content of the obesity suppression function as well as reducing the blood lipid was confirmed to act. Therefore, the coated food of the present invention can be used as a functional food.

Hereinafter, preferred examples are provided to aid in understanding the present invention. However, the following examples are provided only to more easily understand the present invention, and the present invention is not limited to the following examples.

Example 1

Laboratory animals

Normal Sprague-Dawley rats (control)

Type 2 diabetic rats (genetic insulin independent)

Composition of Experiment Group and Experiment Method

In each animal group (normal control group, type 2 diabetes group), the control group (physiological saline administration group), the low-dose group (LCrP 100 mg / kg oral administration for 4 weeks) and the high-dose group (CrP 200 mg / kg four weeks oral administration) ), Glucose tolerance test and insulin sensitivity test were performed. Chromium picolinate (CrP) was suspended in physiological saline and forced to oral administration once a day.

Type 2 diabetic rats were Goto-Kakizaki rats, whose fasting blood glucose level was above 140 mg / dl.

Chromium picolinate (CrP) was orally administered once a day for 4 weeks, and the number of subgroups was 5. Water and food were freely ingested and body weight was measured once a week.

(1) Effect of CrP on Weight Change

Group 0 1 week 2 weeks 3 weeks 4 Weeks Gain (mg) Normal rat Control 242.4 ± 2.5 276 ± 5.5 312 ± 7.6 337.6 ± 4.3 339.5 ± 12.5 101.1 ± 17.5 Low-CrP 240 ± 0.0 273.6 ± 9.9 325 ± 11.7 365.6 ± 15.1 371.8 ± 19.6 131.8 ± 19.6 High-CrP 241.3 ± 2.3 280 ± 6.1 317.5 ± 11.0 337.6 ± 10.9 354.8 ± 16.4 117.2 ± 21.2 Type 2 Diabetic Rats Control 266.4 ± 22.2 286 ± 22.8 307.2 ± 28.3 314.6 ± 25.6 322 ± 23.1 55.6 ± 6.9 Low-CrP 272 ± 13.9 297.2 ± 14.6 323.4 ± 18.3 345.2 ± 18.9 365.6 ± 19.1 93.6 ± 11.3 High-CrP 268.2 ± 11.7 291.4 ± 12.6 314.4 ± 13.4 335.8 ± 17.1 357.4 ± 21.1 89.2 ± 16.9

The weight gain of the normal control group was 101.1 ± 17.5 mg and that of the Low-CrP group and the High-CrP group was increased to 131.8 ± 19.6 mg and 117.2 ± 21.2 mg, respectively. Table 1).

In type 2 diabetic rats, the weight gain in both Low-CrP and High-CrP-administered groups was higher than that of the control group.

(2) Intravenous Glucose Tolerance Test

Hahn et al. (Hahn HJ, Laube F, Kloting I, Kohnert KD, Warzock R: Toxic effects of cyclosporine on the endocrine pancreas of wistar rats.Transplantation 41: 44-47, 1981) and Kang et al. (Kang JS, Kim DS, Lee) CH, Shin IC, Chun YC, Choi HS, Ha JH, Kim JH: Effect of cyclosporine on glucose tolerance in streptozotocin-induced diabetic rats: cyclosporine may deteriorate insulin sensitivity.Transplant Proc 31: 2150-2153, 1999). After taking 50% glucose solution (2 g / kg glucose powder, saline solution) intraperitoneally, blood glucose was measured 10 minutes, 30 minutes, 60 minutes, 90 minutes, 120 minutes, and then the blood glucose-time curve was established and the concentration- The area under time-concentration curve (AUC) was calculated (calculation: AUC _{0-> 120 minutes} = ∫ ₁₂₀ C x dt equation). Since AUC means blood glucose concentration in relation to exogenous glucose load, it was possible to compare responsiveness of endogenous insulin to blood glucose in each group by AUC comparison.

Group 0 10 minutes 30 minutes 60 minutes 90 minutes 120 minutes AUC Type 2 diabetic rat Control 423.6 ± 66.4 527.6 ± 34.7 560.8 ± 32.2 549.6 ± 56.9 583.8 ± 17.8 578.6 ± 39.5 15910 Low-CrP 491.6 ± 24.9 500.2 ± 75.9 535.0 ± 26.3 545.4 ± 21.7 505.4 ± 71.9 556.0 ± 55.4 4199 High-CrP 473.0 ± 62.7 543.0 ± 40.4 528.4 ± 11.4 555.4 ± 34.5 542.4 ± 34.5 542.4 ± 64.3 8030

In normal rats, the variation between subjects was very severe and could not be compared. The change in AUC (mg / d-min) of type 2 diabetic rats was 15910 in the control group, but the low-CrP group was reduced to 4199, which is 26.4% of the control group. . On the other hand, the high-CrP-administered group increased compared to the low-CrP-administered group, but was much lower than the control group.

(3) Effect of CrP on insulin tolerance test (ITT)

5 unit / kg of insulin (Regluar Insulin, human insulin) was administered to the experimental animals once subcutaneously and 30 minutes later, GTT was performed in the same manner as in (2). The blood glucose level was measured by inserting a catheter into the left femoral artery of the rat, collecting 0.5 ml of blood at a predetermined time, and measuring the blood glucose level with GT-4310 (Jeil Chem., Japan) to prepare a time-blood glucose concentration curve. In this case, since the blood glucose level measured means the blood glucose level regulated by the action of exogenous insulin, it may be said to mean insulin sensitivity of peripheral tissues to exogenous insulin.

Group 0 10 minutes 30 minutes 60 minutes 90 minutes 120 minutes AUC Normal rat Control 61.2 ± 15.2 82.8 ± 36.1 45.0 ± 8.5 16.4 ± 6.8 10.4 ± 0.9 10.6 ± 1.3 3636 Low-CrP 70.2 ± 10.9 73.4 ± 14.9 51.2 ± 9.8 20.4 ± 6.8 11.4 ± 2.2 10.2 ± 0.4 3839 High-CrP 65.4 ± 9.5 67.4 ± 7.6 68.6 ± 13.9 36.2 ± 17.6 18.0 ± 7.6 12.2 ± 2.5 4862 Type 2 diabetic rats Control 125.2 ± 6.9 282.6 ± 65.9 252.0 ± 57.7 110.4 ± 43.3 60.4 ± 19.2 47.0 ± 19.8 16994 Low-CrP 135.8 ± 13.6 257.6 ± 77.4 96.0 ± 23.4 67.6 ± 18.6 54.2 ± 11.4 40.0 ± 7.6 11197 High-CrP 154.8 ± 24.1 238.4 ± 62.3 236.8 ± 53.7 139.4 ± 27.2 80.0 ± 24.3 71.0 ± 18.7 17917

In normal rats, there was no significant change in AUC. In type 2 diabetic rats, AUC of control group and high-CrP-treated group was similar, but AUC of low-CrP-treated group decreased significantly (p <0.05). It is believed that blood glucose control by insulin is the best.

(4) Effect of CrP on Insulin Secretion Capacity after Glucose Loading

Rat Insulin RIA Kit (Linco Co. USA) measures insulin concentration in 100 μl of plasma obtained by centrifugation of blood collected 10, 30, 60, 90 and 120 minutes after glucose loading. Was measured by immunofluorescence (RIA; radioimmunoassay), and an insulin concentration-time graph was prepared to calculate an area under time-concentration curve (AUC) (AUC _{0 → 120 min} = ∫ _120). C x dt). At this time, by measuring the measured insulin concentration it is possible to predict the secretion ability of endogenous insulin to the loaded glucose.

Group 0 10 minutes 30 minutes 60 minutes 90 minutes 120 minutes AUC Type 2 diabetic rat Control 0.95 ± 0.16 0.66 ± 0.26 0.60 ± 0.15 0.54 ± 0.29 0.48 ± 0.29 0.39 ± 0.09 66.10 Low-CrP 0.88 ± 0.24 0.68 ± 0.29 0.54 ± 0.11 0.64 ± 0.17 0.59 ± 0.06 0.91 ± 0.15 78.65 High-CrP 0.57 ± 0.25 0.64 ± 0.24 0.52 ± 0.17 0.58 ± 0.22 0.46 ± 0.11 0.50 ± 0.11 64.15

As shown in Table 4, the type 2 diabetic rats were not able to recognize the difference between the AUC and the insulin concentration between the control group and the CrP-administered group. These results suggest that the effects of CrP on the changes in blood glucose and insulin concentrations significantly improve insulin sensitivity, which is closely related to glucose utilization in peripheral tissues regardless of insulin secretion in the Low-CrP group. Was considered to be.

Example 2

In order to confirm the effect of chromium picolinate on obesity, chromium picolinate was administered to ob / ob Zuker rats. The ob / ob rats are obese rats (central experimental zoo).

First, it was divided into a control group, a low dose chromic picolinate administered group (100 mg / kg), a high dose picolinate administered group (200 mg / kg), and chromium picolinate was dissolved in saline and administered orally for 4 weeks. After 4 weeks, fatty tissue, liver, and spleen blood were collected to measure fatty acid composition, and the fatty acid composition is shown in Table 5 below.

Picolinate chromium Control Low dose group High dose group Saturated fatty acid 68.08 54.96 53.00 Monounsaturated fatty acids 21.19 32.41 33.43 Polyunsaturated Fatty Acids 10.73 12.63 13.46 Total ω3PUFA 0.88 0.88 0.9 Total ω6PUFA 10.52 11.1 11.63

As shown in Table 5, the intake of chromium picolinate was found to reduce the content of saturated fatty acids in hereditary obese rats. Thus, it was found that chromic picolinate reduces harmful saturated fatty acids and increases beneficial unsaturated fatty acids (ω-3PUFA, ω-6PUFA).

Example 3

8,700 g of isomalt powder, 1000 g of chromium picolinate and 300 g of maltitol solution (80% DS) were mixed for 15 minutes, and when the mixture became a paste, it was granulated by passing through a 100 mesh sieve. After pulverizing in a ball mixer (ball mixer) to refine the powder to a particle size of less than 180 mesh to prepare a chromium picolinate composition.

Example 4 Preparation of Tableting Candy

The composition of the tableting candy is shown in Table 6 below.

30.4 g of sorbitol (powder), 4 g of picolinate chromium composition prepared in Example 1, 0.7 g of vitamin C, 25 g of isomalt (powder) were mixed, and then the mixture was transferred to a granulator to a maltitol solution (80% DS). After granulation with 5 g, the granules were dried for 24 hours in a drying chamber at 58 ° C., 45-50% RH. The dry sieve was sieve to separate 20-60 mesh particles. The isolate was mixed with 0.5 g of magnesium stearate and tableted with a tableting machine. The tableted product was stored at room temperature for 20 hours at 20-25 ° C. for stability of hardness, and then subjected to a coating process.

A gum was prepared by dissolving 0.66 g of isomalt (powder) in 0.34 g of water and mixing gum gum (sub-coating) with a gum gum solution in which 0.5 g of gum arabic was dissolved in 0.5 g of water. It was. Arabian gum solution (Arabic gum 1.48g, water 1.48g) was mixed with an isomalt solution (24.14 g of isomalt (powder) and 12.44 g of water), and a titanium dioxide solution (0.18 g of titanium dioxide and 0.18 g of water) was mixed. The coatings were repeatedly applied to the cores at 80 ° C. and 80 times.

To resolve the irregular coating and stickiness, the core was mixed with an isomalt solution (isomalt powder 7.4 g, water 3.81 g), gum arabic solution (0.16 g arabic gum, 0.16 g water) and 0.4 g maltitol solution. After coating, the photocating process was performed while spraying 0.075 g of HPMC. Thus, 0.4 g of candy per piece contains 1.6 mg (0.4%) of chromium picolinate.

Raw material name Gross weight (g) ratio(%) Compounding amount Chromium composition Tableting Safflower coating Wrap-up Mania Sorbitol 33.88 33.68 30.4 Picolinate Chromium Composition 4.0 Picolinate 0.4 0.4 0.4 Magnesium stearate 0.5 0.5 0.5 Vitamin c 0.7 0.7 0.7 Isomalt 57.2 56.85 3.48 25.0 0.66 24.14 7.4 Maltitol solution (82% DS) 5.52 5.49 0.12 5.0 0.4 water 18.91 0.84 14.1 3.97 Arabian sword 2.14 2.13 0.5 1.48 0.16 Titanium dioxide 0.18 0.18 0.18 HPMC 0.075 0.07 0.075 Sum 100.595 100%

Example 5

25 g of gum base, 9 g of sorbitol (powder), 1 g of picolinate chromium composition of Example 1, 0.7 g of vitamin C, 25 g of isomalt (powder) and 5 g of maltitol solution were added to a sigma mixer (Σ-mixer). After mixing, the mixture was mixed at 45 ° C. for 20 minutes, the mixture was transferred to a chewing gum maker, and then gum gums were prepared through a process of primary extrusion, primary cooling, secondary extrusion, rolling, molding, and cooling, and then 18 ° C. and 50 °. Aged 1-2 days at -55% RH.

The isomalt solution (0.66 g of isomalt, 0.34 g of water) and the gum arabic solution (0.5 g of arabic gum, 0.5 g of water) were mixed with gum cores and subjected to a gumming process. Core is a mixture of isomalt solution (Isomalt 24.14 g, water 12.44 g) and gum arabic solution (Arabic gum 1.48 g, water 1.48 g) mixed with titanium dioxide solution (0.18 g titanium dioxide, 0.18 g water) at 80 ° C. The process of spraying and drying the coating was repeated 80 times.

To eliminate the irregular coating and swelling, finish the core with a mixture of isomalt solution (isomal 7.4 g, water 3.81 g), gum arabic solution (0.16 g arabic gum, 0.16 g water) and 0.4 g maltitol solution After coating, a photocoating process was carried out while spraying 0.075 g of HPMC. Coated chewing gum was prepared containing 1.6 mg (0.1%) of chromium picolinate per chewing gum (1.6 g). Table 7 below is a composition of chewing gum.

Raw material name Gross weight (g) ratio(%) Compounding amount Chromium composition Tableting Safflower coating Wrap-up Mania Sorbitol 9.87 9.75 9.0 Picolinate Chromium Composition 1.0 Picolinate 0.1 0.10 0.1 Gum base 25.0 24.71 25.0 Vitamin c 0.7 0.69 0.7 Isomalt 57.2 56.53 0.87 25.0 0.66 24.14 7.4 Maltitol solution (82% DS) 5.93 5.86 0.03 5.0 0.4 water 18.91 0.84 14.1 3.97 Arabian sword 2.14 2.11 0.5 1.48 0.16 Titanium dioxide 0.18 0.18 0.18 HPMC 0.075 0.07 0.075 Sum 101.195 100

Example 6

The composition of the candy is shown in Table 8 below.

30.4 g of sorbitol (powder), 15.69 g of xylitol, 4 g of the picolinate chromium composition prepared in Example 1, 0.7 g of vitamin C, 37.5 g of L-carnitine L-tartrate were mixed, and then the mixture was granulated. After granulation with 5 g of maltitol solution (80% DS), the granules were dried for 24 hours in a drying chamber at 58 ° C., 45-50% RH. The dry sieve was sieve to separate 20-60 mesh particles. The isolate was mixed with 0.5 g of magnesium stearate and tableted with a tableting machine. The tableted product was stored at room temperature for 20 hours at 20-25 ° C. for stability of hardness, and then subjected to a coating process.

A gum was prepared by dissolving 0.66 g of isomalt (powder) in 0.34 g of water and mixing gum gum (sub-coating) with a gum gum solution in which 0.5 g of gum arabic was dissolved in 0.5 g of water. It was.

As a coating, 5.0 g of HPMC (hydroxypropyl methylcellulose) and 0.05 g of pigment (Allura Red) were mixed in 0.5 g of water, sprayed and dried to prepare a candy. Candy (0.4 g / piece) contains 1.6 mg (0.4%) of chromium picolinate and 150 mg of carnitine tartarate.

Raw material name Gross weight (g) ratio(%) Compounding amount by process (g) Chrome composition Tableting Safflower Membrane coating Sorbitol 30.4 30.4 Xylitol 15.69 15.69 Picolinate chromium composition 4.0 Picolinate chromium 0.4 0.4 Tartaric Carnitine 37.5 37.5 Magnesium stearate 0.5 0.5 Vitamin c 0.7 0.7 Isomalt 4.14 3.48 0 0.66 Maltitol solution (82% DS) 5.12 0.12 5.0 water 18.91 0.84 18.07 Arabian sword 0.5 0.5 HPMC 5.0 5.0 Pigment 0.05 0.05 Sum 100%

Example 7

The composition of the candy is shown in Table 9 below.

30.4 g of sorbitol (powder), 34.44 g of xylitol, 4 g of the picolinate chromium composition prepared in Example 1, 0.7 g of vitamin C, 18.75 g of L-carnitine L-tartrate were mixed, and then the mixture was granulated. After granulation with 5 g of maltitol solution (80% DS), the granules were dried for 24 hours in a drying chamber at 58 ° C., 45-50% RH. The dry sieve was sieve to separate 20-60 mesh particles. The isolate was mixed with 0.5 g of magnesium stearate and tableted with a tableting machine. The tableted product was stored at room temperature for 20 hours at 20-25 ° C. for stability of hardness, and then subjected to a coating process.

A gum was prepared by dissolving 0.66 g of isomalt (powder) in 0.34 g of water and mixing gum gum (sub-coating) with a gum gum solution in which 0.5 g of gum arabic was dissolved in 0.5 g of water. It was.

As a coating, 5.0 g of HPMC (hydroxypropyl methylcellulose) and 0.05 g of pigment (Allura Red) were mixed in 0.5 g of water, sprayed and dried to prepare a candy. Candy (0.4 g / piece) contains 1.6 mg (0.4%) of chromium picolinate and 150 mg of carnitine tartarate.

Raw material name Gross weight (g) ratio(%) Compounding amount by process (g) Chromium composition Tableting Safflower coating Sorbitol 30.4 30.4 Xylitol 34.44 34.44 Picolinate chromium composition 4.0 Picolinate chromium 0.4 0.4 Tartaric Carnitine 18.75 18.75 Magnesium stearate 0.5 0.5 Vitamin c 0.7 0.7 Isomalt 4.14 3.48 0 0.66 Maltitol solution (82% DS) 5.12 0.12 5.0 water 18.91 0.84 18.07 Arabian sword 0.5 0.5 HPMC 5.0 5.0 Pigment 0.05 0.05 Sum 100

Experimental Example 1

Chromium is known to be involved as a coenzyme in normal fat and protein metabolism. Chromium deficiency is caused by the low bioavailability of chromium, but picolinic acid forms stable complex salts with chromium, improving chromium bioavailability.

To test the bioavailability of chromium, 28 volunteers were administered chromium picolate 3.8 umol chromium (200 μg) or placebo for 42 days for 14 days between treatments according to the double blind cross-over study. The administration of the protein changes in cholesterol, low density lipoprotein (LDL), apolipoprotein B, and LDL were shown in Table 10 below. Chromium picolate group significantly decreased cholesterol, low density lipoprotein (LDL), apolipoprotein B, and LDL protein. Cholesterol values decreased slightly during chromium intake, but no significant difference. Among the measurements, only apolipoprotein B was significantly changed during placebo intake. In view of these results in the present invention, chromium picolate was effective in reducing lipids in the blood in the human body.

administration Chromium picolate Placebo start closing Difference start closing Difference cholesterol Total amount mmol / l 7.1 ± 1.0 6.6 ± 1 -0.5 6.8 ± 0.9 6.8 ± 1.0 0.1 mg / l 276 ± 40 256 ± 41 -19 262 ± 34 265 ± 38 +3 LDL mmol / l 5.7 ± 1.1 5.0 ± 1 -0.6 5.2 ± 0.9 5.3 ± 0.8 +0.1 mg / l 200 ± 39 178 ± 35 -21 184 ± 31 188 ± 30 +4 HDL mmol / l 1.3 ± 0.4 1.4 ± 0.4 -0.1 1.4 ± 0.3 1.4 ± 0.4 0 mg / l 52 ± 16 55 ± 17 -3 53 ± 13 53 ± 17 +0.7 Apolipoprotein Apo A mg / dl 147 ± 28 163 ± 31 +16 153 ± 26 164 ± 40 +11 Apo B mg / dl 155 ± 50 130 ± 45 -25 115 ± 32 129 ± 36 +14 Triglycerides mmol / l 1.9 ± 0.7 1.9 ± 0.9 0 1.9 ± 0.7 2.0 ± 1 +0.1 mg / l 168 ± 65 167 ± 76 -One 165 ± 65 175 ± 88 +10

Experimental Example 2

In the process of spraying the coating composition on the core, a strong adhesion between the cores occurs. In order to offset the cohesion of the cores and prevent moisture migration inside the product, the effectiveness was tested by performing a gumming process by sub-coating before coating the cores. The gumming process is performed before coating the cores to prevent the cores from sticking together.

As a result of performing the saponification process with the composition ratio of the following Table 11, Experimental Example 2-4 significantly reduced the adhesion between the core and the pan in the pan, and also facilitated the drying process of the coated core. In particular, Experimental Example 2-4 can save a drying time of 30% can shorten the process.

2-1 2-2 2-3 2-4 2-5 2-6 Solbitul Powder 60% 65% 50% - - - Sorbitol solution (70% DS) 40% - - - - - Maltitol solution (82% DS) - 35% - - - 35% Isomalt solution (66% DS) - - 50% 50% 100% - Arabian gum solution (50% DS) - - - 50% - 65%

Experimental Example 3

To coat the core, spray the coating solution around the core in a rotating pan, dry it, and then repeat the process of spraying and drying the solution 60 to 120 times depending on the weight of the finished product. The main component of the candy core of Example 4 is isomalt, which is almost impossible to coat because the isomalt is highly adhesive. Therefore, a coating solution suitable for coating was tested with the composition of Table 12 below.

3-1 3-2 3-3 3-4 3-5 3-6 Isomalt solution (66% DS) 92.8% - - 92.8% 92.8% 92.8% Sorbitol solution (70% DS) - 92.8% - - - - Maltitol solution (82% DS) - - 92.8% - - - Arabian gum solution (50% DS) 6.6% 6.6% 6.6% - - 7.2% Geratin Solution (50% DS) - - - 6.6% 7.2% -

As a result, the composition of Experimental Example 3-1 can be used as a coating solution in terms of adhesion between cores, adhesion with pans, drying speed of coated cores, ease of handling of coating solutions during processing, and quality of coated products. Best suited for.

Experimental Example 4

Since isomalt solution is easily recrystallized at a low temperature, if the coating solution is stuck in the nozzle for a long time in the spray nozzle during the coating operation, a recrystallization may be formed and a nozzle may be clogged. Therefore, the composition that can eliminate the nozzle clogging phenomenon was configured and tested as shown in Table 13.

4-1 4-2 4-3 4-4 4-5 4-6 Isomalt solution (55% DS) 100% - - - - - Isomalt solution (66% DS) - 100% - 100% 100% 99.5% Isomalt solution (75% DS) - - 100% - - - Titanium dioxide - - - - 0.5% Solution storage temperature / temperature (℃) 80 ℃ 80 ℃ 80 ℃ 80 ℃ 70 ℃ 80 ℃

As a result of the observation of the exposure clogging phenomenon, 4-1 did not observe recrystallization of the isomalt solution, but it took a lot of time for the preparation, and 4-3 showed the nozzle clogging phenomenon. Also, lowering the storage temperature or product temperature below 70 ℃ increased nozzle clogging. As a result of 4-2, 4-4, 4-5, 4-6, nozzle clogging prevents the concentration of the isomalt solution from 60 to 70% and the storage temperature (temperature) to be around 80 ° C. It was appropriate. In addition, as shown in 4-6, even when 0.5% titanium dioxide was used to maintain the hardness of the product, there was no nozzle clogging.

Experimental Example 5

Since the isomalt sprayed on the core in solution during the coating process produces recrystallization quickly, the solution sprayed on the core does not evenly disperse evenly, and recrystallization forms, resulting in an irregular coating resulting in a very uneven product. The conditions that can eliminate the irregular coating of the core was observed using the following Table 14.

5-1 5-2 5-3 5-4 5-5 5-6 Isomalt solution (66% DS) 100% 100% 95 5 98% 98% 93% Maltitol solution (82% DS) - - 5% - - 5% Arabian gum solution (50% DS) - - - 2 % - 2 % Use of fine powder when core forming - - - 2 % - Solution concentration (Brix adjustment) 63 DS 66 DS 66 DS 66 DS 66 DS 66 DS

When the maltitol solution was mixed with the isomalt solution (5-3) or a certain amount of gum arabic solution was added (5-4), the coating surface was smoothly coated, and the composition of a mixture of maltitol solution and arabic solution of 5-6 was mixed. It was effective in producing this smooth coating.

As mentioned above, the present invention as described above, by effectively adding trivalent picolinate chromium to foods, etc. to prevent and treat a variety of diseases and to prepare a multi- or diabetic food, easy to dry during manufacture, In addition to saving time, the surface of the product is smoothly coated to improve the quality.

Claims (8)

A coating composition comprising chromium picolinate, comprising 80 to 90% by weight of isomalt powder, 5 to 15% by weight of chromium picolinate and 1 to 10% by weight of maltitol solution. The coating composition of claim 1, wherein the coating composition increases insulin sensitivity to type 2 diabetes and acts as a glucose tolerance factor. According to claim 1, wherein the coating composition is a coating composition, characterized in that to reduce the obesity by reducing the saturated fatty acid of adipose tissue. In the method for preparing a coating agent containing chromium picolinate, 80 to 90% by weight of isomalt powder, 5 to 15% by weight of chromium picolinate and 1 to 10% by weight of maltitol solution are mixed on a compounding machine to paste. The method for preparing a coating, characterized in that the granulation of the paste into a powder and then pulverized to produce a particle size of less than 180 mesh. (a) preparing a picolinate chromium composition for mixing, granulating and powdering isomalt, chromium picolinate and maltitol solution; (b) (i) mixing the picolinate chromium composition and sorbitol; (ii) granulating by mixing maltitol solution in the mixture; (iii) drying the granulate to size 20 to 60 mesh; And (iv) tableting the granules; Preparing a core; (c) a saponification step of sub-coating the core with a mixture comprising 30 to 35 wt% isomalt, 23 to 27 wt% arabic gum and 40 to 45 wt% water; (d) spraying and drying the core with a mixture comprising 55-65 wt% isomalt, 1-7 wt% arabic gum, 0.05-1 wt% titanium dioxide, and 30-40 wt% water Coating step to repeat; (c) a finishing coating step of coating with a mixture comprising 55 to 65 wt% isomalt, 1 to 7 wt% gum arabic, 1 to 5 wt% maltitol solution and 30 to 40 wt% water; And (d) photocoating with hydroxypropyl methylcellulose (HPMC) Coating coating method comprising the step. (a) preparing a picolinate chromium composition for mixing, granulating and powdering isomalt, chromium picolinate and maltitol solution; (b) (i) mixing the picolinate chromium composition and sorbitol; (ii) granulating by mixing maltitol solution in the mixture; (iii) drying the granulate to size 20 to 60 mesh; And (iv) tableting the granules; Preparing a core; (c) a saponification step of sub-coating the core with a mixture comprising 30 to 35 wt% isomalt, 23 to 27 wt% arabic gum and 40 to 45 wt% water; And (d) coating method comprising a film coating step of repeating the spraying and drying the mixture containing 75 to 89% by weight of water, and 15 to 25% by weight of hydroxypropyl methylcellulose to the core. According to any one of claims 5 to 6, 50 to 200 parts by weight of isomalt, 50 to 200 parts by weight of the gum base, 40 to 120 parts by weight of the tartaric acid carnitine (L-carnitine L) relative to the coa composition of step (b) tartrate), 25 to 100 parts by weight of xylitol, 0.5 to 5 parts by weight of magnesium stearate, and 1 to 6 parts by weight of vitamin C. A tableting candy or chewing gum comprising chromium picolinate prepared by the method of claim 5.