KR200180302Y1 - Microarrays of sampling tissue - Google Patents
Microarrays of sampling tissue Download PDFInfo
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- KR200180302Y1 KR200180302Y1 KR2019990025914U KR19990025914U KR200180302Y1 KR 200180302 Y1 KR200180302 Y1 KR 200180302Y1 KR 2019990025914 U KR2019990025914 U KR 2019990025914U KR 19990025914 U KR19990025914 U KR 19990025914U KR 200180302 Y1 KR200180302 Y1 KR 200180302Y1
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- G01N1/36—Embedding or analogous mounting of samples
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Abstract
본 고안은 검사를 요하는 조직의 샘플링 장치에 있어서, 복수개의 조직을 하나의 슬라이드면에 배열하여 일시에 검사할수 있도록 되어 이에따른 각 조직의 검사시간을 최소화 할수 있도록 한 샘플링 조직의 미세 배열장치에 관한 것으로서 그 기술적인 구성은, 하나의 슬라이드면에 펀칭기에 의해 채취되는 다수의 조직을 미세 배열토록 하는 것을 요지로 한다.The present invention is a sampling device for tissue that requires inspection, it is possible to test a plurality of tissues arranged on one slide surface at a time to minimize the inspection time of each tissue according to the micro array device of the sampling tissue The technical configuration of the present invention is to make a fine arrangement of a plurality of tissues collected by a punching machine on one slide surface.
Description
본 고안은 검사를 요하는 조직의 샘플링 장치에 있어서, 하나의 슬라이드에 다수의 조직을 미세 배열토록 하는 미세 배열장치에 의해 하나의 슬라이드를 검사하는 공정에 의해 다수의 조직을 동시에 검사할수 있도록 한 샘플링 조직의 미세 배열장치에 관한 것이다.The present invention is a sampling device for a tissue that requires inspection, in which a plurality of tissues can be simultaneously examined by a process of inspecting one slide by a microarray device for finely arranging a plurality of tissues on one slide. It relates to a microarray apparatus of tissue.
일반적으로 알려져 있는 세포조직의 검사에 있어서는, 검사를 요하는 검사체(일반적으로 식물 이나 동물)의 조직을 얇게 자른 상태로 샘플링 하여 투명의 슬라이드에 부착한후 현미경등으로 관찰하고, 이때 상기 검사체 조직의 상태나 이상유무를 비교 검토하는 것이다.In the examination of generally known cellular tissues, the tissues of the specimens (typically plants or animals) requiring examination are sampled in a thinly cut state, attached to a transparent slide, and observed under a microscope or the like. This is to compare and examine the state or abnormality of the organization.
이와같은 기술과 관련된 종래의 조직 샘플링은 도1에 도시한 바와같이, 검사를 요하는 조직(10)을 액상의 파라핀(20)이 충진되는 저장카세트(30)에 삽입한후 파라핀(20)의 고형시 조직(10)이 그 내측에 삽입되는 상태로 일체화 하고, 상기 저장카세트(30)의 내측에서 고형화 되는 조직(10)을 파라핀(20)을 절단도구(40)에 의해 절단하는 작업에 의해 얇게 절단하며, 상기 조직(10)이 포함된 파라핀 편(50)을 슬라이드(60)의 상측에 적치하여 일정 온도로 가열함으로써 조직(10)이 슬라이드(60)면에 일체로 부착되어 현미경(70)등을 통한 조직의 관찰이 가능토록 되는 구성으로 이루어 진다.Conventional tissue sampling related to this technique is shown in Figure 1, after inserting the tissue 10 to be examined in the storage cassette 30 filled with the liquid paraffin 20, the paraffin 20 of the By solidifying the tissue 10 is inserted into its interior when solidified, and cutting the paraffin 20 by the cutting tool 40 to the tissue 10 to be solidified inside the storage cassette 30. By cutting thinly, the paraffin piece 50 including the tissue 10 is placed on the upper side of the slide 60 and heated to a predetermined temperature so that the tissue 10 is integrally attached to the surface of the slide 60 and the microscope 70 It is composed of a configuration that allows observation of the tissue through).
그러나, 상기와 같은 조직 샘플링은, 검사를 요하는 각각의 조직(10)을 샘플링하여 각각의 슬라이드(60)에 부착시켜 조직을 검사하여야 함으로써 다수의 슬라이드를 필요로 하여 검사작업이 번거롭게 됨은 물론 다수의 슬라이드를 필요로 하고, 다수의 슬라이드(60)에 각각 부착되는 조직(10)을 검사하여야 하여 검사 시간이 증가하고, 각각의 조직(10)에 각각의 색인을 부여하여야 하여 작업 부하가 증가하는 등의 문제점들이 있었던 것이다.However, the tissue sampling as described above requires a plurality of slides by sampling each tissue 10 requiring inspection and attaching it to each slide 60 to examine the tissues, and of course, the inspection work becomes cumbersome. It is necessary to examine the tissue 10 attached to each of the plurality of slides 60, the inspection time is increased, and the respective index 10 to each of the tissue 10 to give each index to increase the workload There were problems such as.
본 고안은 상기와 같은 종래의 여러 문제점들을 개선시키기 위한 것으로서 그 목적은, 다수의 조직을 하나의 슬라이드에 의해 검사를 수행할수 있어 이에따른 각 조직의 검사시간을 최소화 할수 있으며, 일정위치로 배열되는 조직에 의해 각각의 조직에 색인을 부여하기 위한 노력이 불필요하고, 파라핀블록에 형성되는 다수의 삽입공에 조직블록을 삽입하는 간단한 구성으로 작업이 손쉽게 이루어짐으로써 각 조직의 샘플링 시간을 최소화 하여 작업성을 향상시키는 샘플링 조직의 미세 배열장치를 제공하는데 있다.The present invention is to improve the various problems as described above, the purpose of which is to test a plurality of tissues by one slide, thereby minimizing the inspection time of each tissue accordingly, arranged in a certain position Effort to index each tissue by the organization is unnecessary, and the work is easily done by inserting the tissue block into a plurality of insertion holes formed in the paraffin block, thereby minimizing the sampling time of each tissue. It is to provide a micro array of sampling tissue to improve the.
도1은 종래의 검사용 조직의 샘플링 작업상태를 도시한 개략도1 is a schematic diagram showing a sampling operation state of a conventional inspection tissue
도2는 본 고안에 따른 샘플링 조직의 미세 배열장치를 도시한 개략도Figure 2 is a schematic diagram showing a microarray arrangement of sampling tissue according to the present invention
도3은 본 고안에 따른 조직의 샘플링 작업상태를 도시한 개략도Figure 3 is a schematic diagram showing a sampling working state of the tissue according to the present invention
도4는 본 고안에 따른 조직의 샘플링용 펀칭기를 도시한 분해도Figure 4 is an exploded view showing a punching machine for sampling tissue according to the present invention
*도면의 주요 부분에 대한 부호의 설명** Description of the symbols for the main parts of the drawings *
100...조직저장부 103...저장카세트100 ... organization storage 103 ... storage cassette
200...펀칭기 231...조직블록200 ... punching machine 231 ... organization block
205...블록채취기 211...블록배출기205 ... Block Taker 211 ... Block Discharger
300...블록저장부 310...조직삽입공300 ... block storage 310 ... tissue insertion hole
331...슬라이드331 ... Slide
상기 목적들을 달성하기 위한 기술적인 구성으로서 본 고안은, 검사를 요하는 복수의 조직이 내측에 각각 삽입될때 그 외측면에 파라핀이 충진되는 복수의 조직저장부와,As a technical configuration for achieving the above object, the present invention, a plurality of tissue storage unit is filled with paraffin on the outer surface when a plurality of tissues to be examined are each inserted into the inside,
상기 저장카세트에 삽입되어 파라핀과 일체로 고형화되는 조직을 일정직경의 조직블록이 되도록 샘플링 하는 펀칭기 및,A punching machine for sampling the tissue inserted into the storage cassette and solidified integrally with the paraffin to be a tissue block having a predetermined diameter;
상기 펀칭기에 의해 샘플링되는 복수의 조직블록이 삽입토록 다수의 조직삽입공이 일체로 형성되는 블록저장부를 포함하는 구성으로 이루어진 샘플링 조직의 미세 배열장치를 마련함에 의한다.By providing a micro-arrangement device of the sampling structure made of a configuration comprising a block storage unit is formed integrally a plurality of tissue insertion holes to insert a plurality of tissue blocks sampled by the punching machine.
이하, 첨부된 도면에 의거하여 본 고안의 실시예를 상세하게 설명하면 다음과 같다.Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.
도2는 본 고안에 따른 샘플링 조직의 미세 배열장치를 도시한 개략도이고, 도3은 본 고안에 따른 조직의 샘플링 작업상태를 도시한 개략도이며, 도4는 본 고안에 따른 조직의 샘플링용 펀칭기를 도시한 분해도로서 본 고안은 조직저장부(100)와 펀칭기(200) 및 블록저장부(300)로서 이루어 진다.Figure 2 is a schematic view showing a microstructure arrangement of sampling tissue according to the present invention, Figure 3 is a schematic diagram showing a sampling operation state of the tissue according to the present invention, Figure 4 is a punching machine for sampling of tissue according to the present invention As shown in the exploded view of the present invention is made of a tissue storage unit 100 and the punching machine 200 and the block storage unit 300.
검사를 요하는 복수의 조직(105)을 저장하는 조직저장부(100)는, 저장카세트(103)의 내측에 각각의 조직(105)이 삽입될때 그 외측면에 파라핀(110)이 일체로 충진토록 된다.Tissue storage unit 100 for storing a plurality of tissues 105 to be examined, the paraffin 110 is integrally filled on the outer surface when each tissue 105 is inserted into the storage cassette 103. It will be.
상기 파라핀(110)과 일체로 고형화 되는 조직(105)을 일정 형상의 조직블록(231)으로 샘플링 하는 펀칭기(200)는, 고정판(203)의 내측에 직경이 상이한 각각의 원통형의 블록채취기(205) 상단이 나사결합되고, 상기 블록채취기(205)에 삽입토록 형성되며 둘레에 다수의 고정요홈(207A)이 형성되는 지지판(209)에 블록배출기(211)가 결합되며, 상기 블록채취기(205)와 블록배출기(211)는 탄성튜브(215)에 의해 연결되고, 상기 지지판(211)이 고정요홈(207B)이 형성되는 고정노브(219)에 나사결합되고, 상기 고정노브(219)의 상측에 돌기(221)가 형성되는 고정캡(223)이 장착된다.The punching machine 200 for sampling the tissue 105 solidified integrally with the paraffin 110 into a tissue block 231 of a predetermined shape is each cylindrical block collector 205 having a different diameter inside the fixing plate 203. The block ejector 211 is coupled to the support plate 209, the upper end of which is screwed, is formed to be inserted into the block collector 205 and a plurality of fixing grooves 207A are formed around the block collector 205, the block collector 205 And the block ejector 211 is connected by an elastic tube 215, the support plate 211 is screwed to the fixing knob 219, the fixing groove 207B is formed, the upper side of the fixing knob 219 Fixing cap 223 is formed is a projection 221 is mounted.
상기 펀칭기(200)에 의해 샘플링되는 복수의 조직블록(231)이 삽입되는 블록 저장부(300)는, 저장케이스(103)의 내측에 파라핀(110)이 충진되어 그 상측면에 다수의 조직 삽입공(310)이 일체로 형성된다.In the block storage unit 300 into which the plurality of tissue blocks 231 sampled by the puncher 200 are inserted, paraffin 110 is filled in the storage case 103 to insert a plurality of tissues on the upper side thereof. The ball 310 is formed integrally.
또한, 상기 블록저장부(300)에 삽입되는 조직블록(231)을 파라핀(110)과 일체로 절단하여 슬라이드(331)의 상측에 부착하는 구성으로 이루어 진다.In addition, the tissue block 231 inserted into the block storage unit 300 is made of a configuration that is integrally cut with the paraffin 110 and attached to the upper side of the slide 331.
이와같은 구성으로 이루어진 본 고안의 작용을 설명하면 다음과 같다.Referring to the operation of the present invention made of such a configuration as follows.
도2 내지 도4에 도시한 바와같이, 검사를 요하는 복수의 조직(105)을 복수의 저장카세트(103)에 각각 침적시켜 그 외측면에 접촉되어 일체로 고형화토록 파라핀(110)을 충진시키고, 상기 파라핀(110)의 고형화가 완료되면 조직(105)과 파라핀(110)이 일체로 되어 하나의 파라핀 블록이 형성된다.As shown in Figures 2 to 4, a plurality of tissues 105 to be examined are deposited on the plurality of storage cassettes 103, respectively, and contacted to the outer surface thereof to completely fill the paraffins 110 so as to solidify. When the solidification of the paraffin 110 is completed, the tissue 105 and the paraffin 110 are integrated to form one paraffin block.
또한, 별도의 저장카세트(103)에 파라핀(110)만을 충진시켜 파라핀 블록을 형성하고, 상기 파라핀 블록에 다수의 조직삽입공(310)을 펀칭기(200)기에 의해 형성하고, 더욱 정밀한 조직삽입공(310)의 형성을 위해서는 별도의 드릴에 의해 가공토록 한다.In addition, by filling only the paraffin 110 in a separate storage cassette 103 to form a paraffin block, a plurality of tissue insertion holes 310 are formed in the paraffin block by a punching machine 200, more precise tissue insertion hole For the formation of the 310 is to be processed by a separate drill.
이어서, 상기 조직(105)과 파라핀(110)이 일체로 고형화되는 저장카세트(103)의 파라핀(110)을 펀칭기(200)에 의해 펀칭하여 원기둥 형상의 조직블록(231)으로 채취하고, 상기 펀칭기(200)에 의해 채취된 각각 상이한 부위의 조직블록(231)을 별도의 저장카세트(103)에 형성되는 파라핀 블록의 조직삽입공(310)에 각각 삽입한다.Subsequently, the paraffin 110 of the storage cassette 103 in which the tissue 105 and the paraffin 110 are solidified integrally is punched out by the punching machine 200, and collected into a cylindrical tissue block 231, and the punching machine Tissue blocks 231 of different sites collected by 200 are inserted into tissue insertion holes 310 of paraffin blocks formed in separate storage cassettes 103, respectively.
상기 조직블록(231)을 조직삽입공(310)에 삽입한후 칼날(400)등의 절단도구에 의해 박막(薄膜)의 형태로 얇게 절단(일정각도를 유지하여 절단하면 용이하게 절단됨)하면 파라핀(110)과 일체로 형성되는 각각의 상이한 조직(105)이 일정 상태로 배열토록 되는 파라핀 편(420)이 형성된다.After inserting the tissue block 231 into the tissue insertion hole 310 and cut thinly in the form of a thin film (薄膜) by a cutting tool such as a blade 400 (to be cut easily while maintaining a constant angle) A paraffin piece 420 is formed such that each different tissue 105 formed integrally with the paraffin 110 is arranged in a predetermined state.
상기 조직(105)과 파라핀(110)이 일체로 절단되는 다중조직 샘플인 파라핀 편(420)을 슬라이드(331)의 상측에 놓은 상태에서 가열한후 고착처리를 수행하면 복수의 조직(105)이 슬라이드(331)의 상측에 일체로 고착된다.When the paraffin piece 420, which is a multi-tissue sample in which the tissue 105 and the paraffin 110 are integrally cut, is heated in a state of being placed on the upper side of the slide 331, a plurality of tissues 105 are fixed. It is fixed to the upper side of the slide 331 integrally.
이에따른 상기 장치에 의해 슬라이드(331)의 상측에 일정형상(일반적으로는 좌측에서 우측방향으로 일렬번호순)으로 배열되어 고착되는 복수의 조직(105)을 현미경(410)등에 의해 검사를 수행할때 한번의 검사에 의해 다수의 조직을 일시에 간단하게 검사할수 있게된다.Accordingly, when the examination is performed by the microscope 410 or the like, a plurality of tissues 105 arranged and fixed in a predetermined shape (typically in a left-to-right direction) on the upper side of the slide 331 by the apparatus. A single test makes it easy to examine multiple tissues at one time.
상기 조직블록(231)을 채취및 방출시키는 펀칭기(200)는, 나사산이 형성되는 고정판(203)의 내측에 직경이 상이한 각각의 원통형의 블록채취기(205)가 나사결합토록 형성되어 다양한 직경의 조직블록(231) 형성이 가능토록 된다.Punching machine 200 for collecting and discharging the tissue block 231, the cylindrical block collector 205 of different diameters are formed in the inner side of the fixed plate 203, the thread is formed so that the screw coupling is formed of various diameters Block 231 can be formed.
또한, 상기 블록채취기(205)에 삽입토록 다양한 직경으로 형성되는 원주형의 블록배출기(211)는, 둘레에 다수의 고정요홈(207A)이 형성되는 지지판(209)에 일체로 고정되어 고정요홈(207B)이 형성되는 고정노브(219)와 나사결합된다.In addition, the cylindrical block ejector 211 is formed in a variety of diameters so as to be inserted into the block collector 205, is fixed integrally fixed to the support plate 209 is formed with a plurality of fixing grooves 207A around the fixed groove ( 207B is screwed into the fixed knob 219 is formed.
상기 고정노브(219)에 지지판(209)이 나사결합 될때 상기 고정요홈(207A)(207B)에 고정캡(223)의 돌기(221)를 삽입하면 지지판(209)이 일정회전상태(회전시 일체로 연결되는 블록배출기(211)의 높이가 조정됨)에서 고정됨으로써 상이한 높이를 갖는 블록채취기(205)가 적용될때 블록채취기(205)의 내측에 삽입되는 블록배출기(211)의 높이 조절이 가능토록 되어 일정규격의 조직블록(231) 채취가 가능토록 된다.When the support plate 209 is screwed to the fixing knob 219 and the projection 221 of the fixing cap 223 is inserted into the fixing recess 207A and 207B, the support plate 209 is rotated at a constant state (when rotating. The height of the block ejector 211 inserted into the block extractor 205 when the block extractor 205 having a different height is applied is fixed so that the height of the block ejector 211 connected to the control unit is adjusted. It becomes possible to collect the tissue block 231 of a certain standard.
또한, 상기 블록채취기(205)의 고정판(203)과 블록배출기(211)의 지지판(209)에는 요부(미도시)가 각각 형성되어 탄성튜브(215)의 양단이 밀착되어 블록채취기(205)와 블록 배출기(211)가 상호 분리되는 것을 미연에 방지한다.In addition, recesses (not shown) are respectively formed on the fixing plate 203 of the block collector 205 and the support plate 209 of the block ejector 211 so that both ends of the elastic tube 215 are in close contact with each other. The block ejectors 211 are prevented from being separated from each other.
상기 블록채취기(205)를 파라핀 블록의 상측에서 놓은상태에서 고정판(203)을 압입하면 파라핀 블록이 블록채취기(205) 내측의 블록배출기(211)를 밀면서 조직블록(231)형상으로 블록채취기(205) 내측에 샘플링된다.In the state in which the block collector 205 is placed on the upper side of the paraffin block, the fixed plate 203 is press-fitted, and the paraffin block pushes the block ejector 211 inside the block collector 205 while the block collector 205 is in the shape of the tissue block 231. ) Is sampled inside.
이어서, 상기 블록채취기(205) 내측의 조직블록(231)을 조직삽입공(310)에 삽입할때 상기 블록채취기(205)를 조직삽입공(310)의 상측에 놓은 상태에서 고정노브(219)를 압입하면 블록배출기(211)가 하향하면서 조직블록(231)을 배출토록 하고, 상기 각각의 조직블록(231)을 채취하는 펀칭기(200)와 다수의 조직삽입공(310)이 형성되는 블록저장부(300)에 의해 다수의 조직을 동시에 검사가능토록 하는 것이다.Subsequently, when the tissue block 231 inside the block extractor 205 is inserted into the tissue insertion hole 310, the fixed knob 219 is placed in a state where the block extractor 205 is placed above the tissue insertion hole 310. Injecting the block discharger 211 is downward to discharge the tissue block 231, the punching machine 200 and each of the tissue block 231 to collect the block storage block formed with a plurality of tissue insertion hole 310 is formed The unit 300 allows multiple tissues to be examined simultaneously.
이와같이 본 고안에 따른 샘플링 조직의 미세 배열장치에 의하면, 다수의 조직을 하나의 슬라이드에 의해 검사할수 있어 이에따른 각 조직의 검사시간을 최소화 할수 있으며, 일정위치로 배열되는 조직에 의해 각각의 조직에 색인을 부여하기 위한 노력이 불필요하고, 저장블록에 형성되는 삽입공에 블록을 삽입하는 간단한 구성으로 작업이 손쉽게 이루어짐으로써 각 조직의 샘플링 시간을 최소화 하여 작업성을 향상시키는 등의 우수한 효과가 있다.Thus, according to the microarray arrangement of sampling tissues according to the present invention, it is possible to inspect a plurality of tissues by one slide, thereby minimizing the inspection time of each tissue, and to each tissue by the tissues arranged at a predetermined position. Effort to give an index is unnecessary, and the work is easily performed by inserting the block into the insertion hole formed in the storage block, thereby improving the workability by minimizing the sampling time of each tissue.
Claims (2)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR2019990025914U KR200180302Y1 (en) | 1999-11-24 | 1999-11-24 | Microarrays of sampling tissue |
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| KR2019990025914U KR200180302Y1 (en) | 1999-11-24 | 1999-11-24 | Microarrays of sampling tissue |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7070950B2 (en) | 2003-06-17 | 2006-07-04 | Young-Min Song | Recipient block and method for preparation thereof |
| WO2008069502A1 (en) * | 2006-12-06 | 2008-06-12 | Seung Min Song | Mold of recipient block and usage thereof |
| KR101022008B1 (en) | 2008-01-09 | 2011-03-16 | 송승민 | Tissue Sample Array Apparatus |
-
1999
- 1999-11-24 KR KR2019990025914U patent/KR200180302Y1/en not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7070950B2 (en) | 2003-06-17 | 2006-07-04 | Young-Min Song | Recipient block and method for preparation thereof |
| WO2008069502A1 (en) * | 2006-12-06 | 2008-06-12 | Seung Min Song | Mold of recipient block and usage thereof |
| KR101022008B1 (en) | 2008-01-09 | 2011-03-16 | 송승민 | Tissue Sample Array Apparatus |
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