KR20010069870A - Polyacrylamide hydrogel used for antiwrinkling, reform, enlargement of body tissues including breast and pennis, and substitute of eye ball's vitreous - Google Patents
Polyacrylamide hydrogel used for antiwrinkling, reform, enlargement of body tissues including breast and pennis, and substitute of eye ball's vitreous Download PDFInfo
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- KR20010069870A KR20010069870A KR1020010026611A KR20010026611A KR20010069870A KR 20010069870 A KR20010069870 A KR 20010069870A KR 1020010026611 A KR1020010026611 A KR 1020010026611A KR 20010026611 A KR20010026611 A KR 20010026611A KR 20010069870 A KR20010069870 A KR 20010069870A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/04—Materials or treatment for tissue regeneration for mammary reconstruction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
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Abstract
Description
본 발명은 미용성형 분야의 안면주름제거, 윤곽교정, 유방과 성기확대를 포함한 인체조직확대와 안구 유리체 대체물질에 사용되는 폴리아크릴아마이드 하이드로겔에 관한 것이다.The present invention relates to a polyacrylamide hydrogel used in facial tissue removal, contour correction, enlargement of human tissues including breast and genital enlargement and ocular vitreous substitute in the field of cosmetic surgery.
최근 미용에 관한 관심과 의학기술의 발달로 주름살 제거, 윤곽교정, 유방과 성기확대를 포함한 인체조직확대 수술이 널리 시술되고 있다. 특히 선천적으로 또는 질병이나 악성종양으로 인해 유방이 빈약한 여성들은 유방확대 수술에 큰 관심을 보이고 있다. 종래에는 고체 실리콘 주머니에 액체 실리콘을 채워 유방확대수술에 사용하였는데 이는 촉감은 좋으나, 외부충격에 의해 터졌을 때 액체 실리콘이 인체에 스며들어 자가면역질환 등의 부작용을 유발하여 1995년 미국 식품의약국(FDA)에서는 액체 실리콘의 사용을 금지시켰다. 그 이후 고농도의 포도당겔을 넣은 주머니를 유방확대에 사용하였으나, 이 역시 균열시 엄청난 부종과 염증이 생기는 사례가 많아 근래에는 생리식염수를 넣은 주머니를 주로 사용하고 있다. 그러나 생리 식염수를 넣은 주머니의 경우 안전성에는 문제가 없으나 질감과 촉감이 유방과 너무 다른 단점을 가지고 있어 새로운 유방보형물의 발명이 지대하게 필요한 실정이다.Recently, with interest in beauty and the development of medical technology, human tissue augmentation surgery including wrinkle removal, contour correction, breast and genital enlargement has been widely performed. In particular, women with poor breasts due to innate or diseased or malignant tumors are showing great interest in breast augmentation surgery. Conventionally, liquid silicone was used for breast augmentation by filling liquid silicone bag, but it was good to touch, but liquid silicone penetrated into human body when it burst by external shock, causing side effects such as autoimmune diseases. FDA has banned the use of liquid silicone. Since then, a bag containing high concentration of glucose gel has been used for breast augmentation, but there are also cases of enormous swelling and inflammation when cracking. Recently, saline bag is used mainly. However, saline sachets have no problems with safety, but texture and touch have a drawback that is too different from that of breasts, and the invention of new breast implants is a great need.
한편, 유리체는 투명한 물질로 얇은 섬유성 막으로 싸여있는 투명한 공모양의 구조물로, 겔상태이며 아주 투명하고 혈관이 없으며, 눈 전체용적의 ⅔정도를 차지하여 눈이 공모양의 형태를 유지하는데 중요한 역할을 한다. 유리체는 빛이 망막으로 안전하게 도달할 수 있도록 하는 역할을 수행하는데, 심한 안구 손상을 입은 환자의 경우에는 유리체가 새어나와서 실명하는 경우도 있다. 이런 경우 손상된 환자의 안구를 제거하고 인공안구를 이식하기 때문에 환자는 시력을 잃을 수 밖에 없는데, 안구내부에 폴리아크릴 아마이드 하이드로겔을 이용하여 투명한 구를 만들어 인공 유리체로 대체하게 되면 강도도 좋고 모양을 잘 유지한다. 이러한 인공유리체로 실리콘 계열의 물질을 주입하는 방법이 개발되기도 했으나, 거부반응이 일어나는 부작용들이 있어 문제가 있었다. 반면 폴리아크릴아마이드 하이드로겔은 생체에 안전하므로 실명위기에 놓인 안구손상 환자들의 실명을 막을 수 있다.On the other hand, the vitreous is a transparent ball-shaped structure, which is a transparent material wrapped in a thin fibrous membrane, and is gel-like, very transparent, without blood vessels, and occupies the entire volume of the eye, which is important for the eye to maintain the shape of the ball. Play a role. The vitreous is responsible for ensuring that light reaches the retina safely. In patients with severe eye damage, the vitreous may leak and become blind. In this case, the patient's eyes have to lose sight because the damaged eye is removed and the artificial eye is implanted.However, when the transparent sphere is made by using polyacrylamide hydrogel inside the eye and replaced by an artificial vitreous body, the strength and shape are improved. Keep well. Although a method of injecting a silicon-based material into the artificial glass body has been developed, there are problems due to side effects of rejection. Polyacrylamide hydrogels, on the other hand, are safe for humans and can prevent blindness in patients with eye damage.
따라서 인체조직과 유사하게 만들어 환자들의 만족감을 높일 수 있되, 무해한 폴리아크릴아마이드 하이드로겔을 이용하여 안면주름제거, 윤곽교정, 유방과 성기확대를 포함한 인체조직확대와 안구 유리체 대체물질의 소재로 사용할 수 있도록 발명하게 되었다.Therefore, it can be made similar to human tissue and can increase patient satisfaction, but it can be used as a material for human tissue enlargement and ocular vitreous substitute including facial wrinkle removal, contour correction, breast and genital enlargement using harmless polyacrylamide hydrogel. Invented so that.
본 발명은 폴리아크릴아마이드 하이드로겔을 이용하여 생체조직의 질감과 촉감이 거의 유사한 보형물을 만드는 것이다. 아크릴아마이드의 농도를 조절하여 폴리아크릴아마이드 하이드로겔의 점성을 조절할 수 있기 때문에 겔의 점도 조절로 환자마다 차이를 보이는 피부나 유방, 성기, 안구 유리체의 단단한 정도에 맞게 겔을 제조할 수 있고 유방확대와 인공 안구유리체 시술의 경우에는 주머니속에 파우더 상태의 폴리아크릴아마이드 하이드로겔을 넣어 적은 상처를 내면서 시술한 다음 액을 주입하여 겔 상태로 전환할 수 있는 기술적 장점이 있다. 폴리아크릴아마이드 하이드로겔은 인체에 거의 무해하기 때문에 주름살제거나 윤곽교정 등에도 기존 제제의 대체용으로 쓰일 수 있다.The present invention uses a polyacrylamide hydrogel to make the implant almost similar in texture and texture to biological tissues. Since the viscosity of polyacrylamide hydrogel can be adjusted by controlling the concentration of acrylamide, the gel can be manufactured according to the firmness of skin, breast, genital, and ocular vitreous, which is different from patient to patient. In the case of artificial ocular vitreous treatment, the polyacrylamide hydrogel in a powder state is put in a pocket, and a technical wound can be converted into a gel state by injecting a solution after injecting a small wound. Since polyacrylamide hydrogel is almost harmless to human body, it can be used as a substitute for existing formulations for wrinkle removal or contour correction.
폴리아크릴아마이드 하이드로겔은 아크릴아마이드 단량체를 중합반응과 교차반응을 시켜 만든 망사형태의 중합물이다. 이때 반응하지 않은 미량의 단량체는 신경독소로서 인체에 유해하다고 알려져 있기 때문에 제거하여 사용한다. 이렇게 만든 본 발명품은 놀랄만한 물분자 흡인력을 통해 피부조직의 세포들 사이에서 스폰지와 같은 구조를 형성함으로써 피부의 부피유지와 쿠션작용, 피부보습, 윤활작용, 상처치유 및 세포의 물질대사과정을 도와줄 수 있다.Polyacrylamide hydrogel is a mesh-type polymer made by cross-reacting acrylamide monomer with a polymerization reaction. At this time, the small amount of unreacted monomer is used as it is known to be harmful to human body as neurotoxin. In this way, the present invention forms a sponge-like structure between the cells of skin tissues through the amazing water molecule attraction, helping to maintain skin volume, cushion, skin moisturize, lubricate, heal wounds and metabolism of cells. Can give
유방확대, 성기확대를 포함한 인체의 조직확대, 주름살제거, 윤곽교정과 안구유리체 대체물질로 인체 조직내에 주입하는 폴리아크릴아마이드 하이드로겔은 인체조직에 따라 1 내지 20중량%를 사용할 수 있는데 특히 3내지 4%중량의 점도가 바람직하다. 폴리아크릴아마이드 하이드로겔을 유방확대, 성기확대를 포함한 인체의조직확대, 주름살제거, 윤곽교정과 안구유리체 대체물질로 사용할 때 직접 주사하는 방법을 사용하여 시술할 수 있으며, 실리콘 등의 주머니에 주입하여 시술하는 방법으로 인체 조직내에 주입할 수 있다. 주머니에 주입하는 시술을 할 경우 폴리아크릴아마이드는 파우더 상태로 유방주머니와 유리체주머니에 넣고 유방과 안구에 시술한 다음 액을 주입하여 겔상태로 변환하여 유방확대와 인공 유리체 시술에 사용할 경우 절개부위가 작아도 되는 장점을 갖게 된다.Polyacrylamide hydrogel injected into human tissue with breast enlargement, genital enlargement, tissue enlargement, wrinkle removal, contour correction and ocular vitreous substitute can be used in 1 ~ 20% by weight depending on human tissue, especially 3 to Viscosity of 4% by weight is preferred. When polyacrylamide hydrogel is used as a tissue enlargement, wrinkle removal, contour correction and ocular vitreous substitute, including breast enlargement and genital enlargement, it can be used by direct injection method. It can be injected into human tissue by the procedure. In case of injecting into pouch, polyacrylamide is powdered into breast pocket and vitreous bag, and then put into breast and eye, and then injected into liquid to gel state. It has the advantage of being small.
즉, 본 발명에서 사용하는 폴리아크릴아마이드 하이드로겔을 겔상태 그대로, 분말상태로 만들어 사용할 수 있으며, 사용하는 폴리아크릴아마이드 하이드로겔에는 신경독소로 알려진 신경독소가 없어야 하며, 직접 주입할 수도 있으며, 주머니에 넣어 사용하여도 된다.That is, the polyacrylamide hydrogel used in the present invention may be used as it is in a gel state, and in a powder state, and the polyacrylamide hydrogel used should be free of neurotoxins known as neurotoxins, and may be directly injected. It can also be used in.
본 발명을 통하여 폴리아크릴아마이드 하이드로겔은 성형분야의 안면 주름제거, 윤곽교정, 유방과 성기확대를 포함한 인체조직확대 시술과 안구 유리체 대체물질로 사용하게 되면 기존 제제들의 인체조직같지 않은 이질감과 인체에 유해한 단점들을 극복하는 효과가 있다.Polyacrylamide hydrogel through the present invention when used as a tissue replacement procedure and ocular vitreous substitutes, including facial wrinkle removal, contour correction, breast and genital enlargement in the field of molding and the heterogeneity of the conventional formulations It has the effect of overcoming harmful shortcomings.
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KR100501225B1 (en) * | 2001-12-13 | 2005-07-18 | 휴젤(주) | Monomer extracted polyacrylamide and preparation method thereof |
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KR100501225B1 (en) * | 2001-12-13 | 2005-07-18 | 휴젤(주) | Monomer extracted polyacrylamide and preparation method thereof |
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