KR20010026619A - Patch preparation for curing a part bitten by insect - Google Patents

Patch preparation for curing a part bitten by insect Download PDF

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Publication number
KR20010026619A
KR20010026619A KR1019990038010A KR19990038010A KR20010026619A KR 20010026619 A KR20010026619 A KR 20010026619A KR 1019990038010 A KR1019990038010 A KR 1019990038010A KR 19990038010 A KR19990038010 A KR 19990038010A KR 20010026619 A KR20010026619 A KR 20010026619A
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KR
South Korea
Prior art keywords
insect
bitten
treatment
patch preparation
supporting body
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KR1019990038010A
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Korean (ko)
Inventor
김동회
Original Assignee
김동회
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Priority to KR1019990038010A priority Critical patent/KR20010026619A/en
Publication of KR20010026619A publication Critical patent/KR20010026619A/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Abstract

PURPOSE: A patch preparation for treatment of insect-bitten part is provided, which prevents getting worse of the affected part by blocking insect-bitten part from the exterior, and makes medicines can be work for a long time. CONSTITUTION: The patch preparation for treatment of insect-bitten site is comprised of: a supporting body(1); a layer containing medicines for insect-bitten part(2) showing smaller surface than the supporting body(1)(e.g., non-woven fabric, cotton fabric, woven fabric, mono-layered film, multi-layered laminate film, etc); an adhesive layer(3)(e.g., acrylic resin containing aliphatic alcohol and alkyl metacrylate ester) beside the layer containing medicines for insect-bitten part(2) on the supporting body(1); a separating sheet(4) on the layer containing medicines for insect-bitten part(2) and the adhesive layer(3). The adhesive layer(3) can contain resins, plasticizer, filler and anti-oxidant optionally, and which can also contain organic high molecular particles and/or inorganic substances to improve adhesive property.

Description

벌레물린 부위 처치용 패취제제{Patch preparation for curing a part bitten by insect}Patch preparation for curing a part bitten by insect}

본 발명은 벌레물린 부위를 치료하기 위한 패취 제제에 관한 것이다.The present invention relates to a patch formulation for treating an insect bite site.

여기서 용어 '벌레물린 부위'는 벌에 쏘이거나 모기에 물린 신체 부위를 지칭하는 것이다.The term 'worm bite site' is used herein to refer to parts of the body that are stung by bees or mosquito bites.

일반적으로 벌레물린 부위를 치료하는 데에는 액상이나 크림상의 제제를 환부에 도포하는 방법이 이용되고 있다. 그러나 이러한 제제는 이를 도포한 벌레물린 부위가 가렵기 때문에 의식적 또는 무의식적으로 긁게 되고, 그 결과 환부가 악화되어 쉽게 낳지 않고 심한 경우에는 병원에 입원하게 되는 경우도 종종 발생하는 문제점이 있고, 또한 벌레물린 부위에 도포한 액상이나 크림상의 제제가 증발되거나 지워져 자주 도포하여야 하는 번거로움이 있는 것이다.In general, a method of applying a liquid or creamy agent to the affected area is used to treat the bite site. However, these preparations are scratched consciously or unconsciously because of the itching of the bite applied to it, as a result of the deterioration of the affected area is not easily produced, and in severe cases, often hospitalized, there is also a problem that the bite site Liquid or creamy formulations applied to the product are often evaporated or erased and have to be applied frequently.

따라서 본 발명은 상기한 문제점이 없이 벌레물린 부위를 효과적으로 치료할 수 있는 새로운 제제를 제공하는 것을 과제로 한다.Accordingly, an object of the present invention is to provide a new formulation capable of effectively treating an insect bite site without the above problem.

도 1은 본 발명에 따르는 벌레물린 부위 처치용 패취제제의 구조를 개략적으로 나타낸 도면이다.1 is a view schematically showing the structure of a patch preparation for insect bite treatment according to the present invention.

* 도면의 주요부분에 대한 부호의 설명 *Explanation of symbols on the main parts of the drawings

1 : 지지체1: support

2 : 벌레물린 부위 치료제-함유층2: insect bite site treatment agent-containing layer

3 : 점착층3: adhesion layer

4 : 이형지4: release paper

상기한 과제를 해결하기 위한 본 발명에 의하면 벌레물린 부위 치료제가 함유된 것을 특징으로 하는 벌레물린 부위 처치용 패취제제가 제공된다.According to the present invention for solving the above problems there is provided a patch for insect bite site treatment characterized in that the insect bite site treatment is contained.

이하 본 발명을 첨부도면을 참조하여 보다 상세하게 설명하기로 한다.Hereinafter, the present invention will be described in more detail with reference to the accompanying drawings.

도 1에는 본 발명의 일 구현에 따르는 벌레물린 부위 처치용 패취제제가 도시된다. 도시되는 패취제제는 지지체(1), 지지체 상의 내측에 위치하여 적층되며 지지체(1) 보다 작은 면적을 갖는 벌레물린 부위 치료제-함유층(2), 상기 치료제-함유층(2) 외부에서 지지체(1)상에 적층되는 점착층(3) 및 이형지(4)가 적층된다.1 shows a patch for insect bite treatment according to an embodiment of the present invention. The patch agent shown is a support (1), a bite-site therapeutic agent-containing layer (2) having a smaller area than the support (1), stacked on the inside of the support, and the support (1) outside the therapeutic agent-containing layer (2) The adhesive layer 3 and the release paper 4 laminated | stacked on are laminated | stacked.

지지체(1)로서는 종래의 패취제제에 이용되고 있는 지지체가 사용될 수 있다. 예를 들어, 부직포, 면포, 직포 등의 공기나 수분의 투과성이 좋은 재질이나 폴리에틸렌테레프탈레이트, 폴리우레탄, 폴리에틸렌, 폴리프로필렌, 알루미늄처리된 폴리에틸렌 등이 단층 필름 또는 다층의 라미네이트 필름 등을 이용할 수 있고, 필요에 따라서는 부직포나 면포를 수분투과능력이 없는 플라스틱 필름과 적층하여 사용할 수 있다.As the support 1, the support used for the conventional patch agent can be used. For example, a single layer film or a multilayer laminate film may be used for materials having good permeability to air or moisture such as nonwoven fabric, cotton cloth, and woven fabric, polyethylene terephthalate, polyurethane, polyethylene, polypropylene, and aluminum treated polyethylene. If necessary, the nonwoven fabric or cotton cloth may be laminated with a plastic film having no moisture permeability.

특별히 제한하기 위한 것은 아니지만, 벌레물린 부위 치료제-함유층(2)은 별도의 지지체에 벌레물린 부위 치료제를 적재하여 구성시키거나, 또는 상기 지지체(1)에 벌레물린 부위 치료제를 직접 적재하여 구성시킬 수도 있다. 벌레물린 부위 치료제는 당분야에 잘 알려진 통상의 것을 사용할 수 있으며, 그 양은 원하는 결과를 얻기에 충분한 양으로 하면 된다.Although not particularly limited, the insect bite site treatment-containing layer 2 may be configured by loading the bite site treatment on a separate support or by directly loading the bite site treatment on the support 1. have. The insect bite site treatment may be a conventional one well known in the art, the amount may be sufficient to achieve the desired result.

점착층을 구성하는 점착기재도 종래의 패취제제에 이용되고 있는 점착기제가 사용될 수 있다. 예를 들어 아크릴계 수지를 이용할 수 있다. 아크릴계 수지로서 탄소수 4-18의 지방족 알코올과 (메타)아크릴산알킬 에스테르와의 (공)중합체 또는 탄소수 4-18의 알킬기를 갖는 (메타)아크릴산알킬에스테르와의 (공)중합체 또는 상이한 관능성의 모노머와의 중합체인 점착성 수지가 사용될 수 있다. 상기 (메타)아크릴산 공중합체로서는 부틸아크릴레이트, 이소부틸아크릴레이트, 헥실아크릴레이트, 옥틸아크릴레이트, 2-에틸헥실아크릴레이트, 이소옥틸아크릴레이트, 데실아크릴레이트, 이소데실아크릴레이트, 라우릴아크릴레이트, 스테아릴아크릴레이트, 메틸메타크릴레이트, 에틸메타크릴레이트, 부틸메타크릴레이트, 이소부틸메타크릴레이트, 2-에틸헥실메타크릴레이트, 이소옥틸메타크릴레이트, 데실메타크릴레이트 등이 있다. 또 상기 관능성 모노머로서는 히드록시기를 가지고 있는 모노머, 카르복실기를 갖는 모노머, 아미드기를 갖는 모노머, 등이 사용될 수 있다. 히드록시기를 가지고 있는 모노머로서는 2-히드록시에틸(메타)아크릴레이트, 히드록시프로필(메타)아크릴레이트 등이 있다. 카르복실기를 가지는 모노머로서는 아크릴산, 메타크릴산 등의 α-β 불포화 카르복실산; 말레인산 부틸 등의 말레인산 모노알킬에스테르; 말레인산, 푸마르산, 크로돈산 등이 있으며, 무수말레인산도 말레인산과 같은 형태의 (공)중합체를 얻을 수 있다. 아미드기를 갖는 모노머로서는 아크릴아미드, 디메틸아크릴아미드, 디에틸아크릴아미드 등의 알킬(메타)아크릴아미드; 부톡시메틸아크릴아미드, 에톡시메틸아크릴아미드 등의 알킬에틸메틸올(메타)아크릴아미드; 디아세톤아크릴아미드; 비닐피롤리돈; 디메틸아미노아크릴레이트 등이 있다. 상기 이외의 공중합체 모노머로서 초산비닐, 스티렌, α-메틸스티렌, 아크릴로니트릴, 에틸렌, 프로필렌, 부타디엔 등이 있다.The adhesive base material which comprises an adhesive layer can also use the adhesive agent used for the conventional patch agent. For example, acrylic resin can be used. (Co) polymer of a C4-18 aliphatic alcohol and a (meth) acrylic acid alkyl ester or a (co) polymer of (meth) acrylic acid alkylester having an alkyl group of 4-18 carbon atoms or a monomer having different functionalities An adhesive resin which is a polymer of may be used. Examples of the (meth) acrylic acid copolymer include butyl acrylate, isobutyl acrylate, hexyl acrylate, octyl acrylate, 2-ethylhexyl acrylate, isooctyl acrylate, decyl acrylate, isodecyl acrylate and lauryl acrylate. , Stearyl acrylate, methyl methacrylate, ethyl methacrylate, butyl methacrylate, isobutyl methacrylate, 2-ethylhexyl methacrylate, isooctyl methacrylate, decyl methacrylate and the like. Moreover, as said functional monomer, the monomer which has a hydroxyl group, the monomer which has a carboxyl group, the monomer which has an amide group, etc. can be used. As a monomer which has a hydroxy group, 2-hydroxyethyl (meth) acrylate, hydroxypropyl (meth) acrylate, etc. are mentioned. As a monomer which has a carboxyl group, (alpha)-(beta) unsaturated carboxylic acids, such as acrylic acid and methacrylic acid; Maleic acid monoalkyl esters such as butyl maleate; There are maleic acid, fumaric acid, crodonic acid and the like, and maleic anhydride can also obtain a (co) polymer in the same form as maleic acid. As a monomer which has an amide group, Alkyl (meth) acrylamide, such as acrylamide, dimethyl acrylamide, and diethyl acrylamide; Alkyl ethyl methylol (meth) acrylamides such as butoxymethyl acrylamide and ethoxymethyl acrylamide; Diacetone acrylamide; Vinylpyrrolidone; Dimethylaminoacrylate and the like. Copolymer monomers other than the above include vinyl acetate, styrene, α-methylstyrene, acrylonitrile, ethylene, propylene, butadiene and the like.

상기 점착기제 중에는 필요에 따라 각종 배합제, 예를 들면 로진계 수지, 폴리테르펜계수지, 쿠마로인덴계수지, 석유계 수지, 테르펜페놀계 수지 등의 점착부여제; 액상 폴리부텐, 광유, 라놀린, 액상 폴리이소프렌, 액상폴리아크릴레이트 등의 가소제, 충전제, 산화방지제 등을 첨가할 수 있다. 또한 점착특성 개선을 목적으로 셀룰로오스, 폴리에틸렌, 폴리아미드, 폴리프로필렌, 폴리에틸렌테레프탈레이트, 알긴산, 히알루론산, 키틴 및 그의 유도체 등의 유기 고분자 미립자 및/또는 산화아연, 산화칼슘, 실리카, 카오린, 탈크, 티타늄옥사이드 등의 무기물을 배합할 수도 있다.In the said adhesive agent, if necessary, various compounding agents, For example, tackifiers, such as rosin type resin, polyterpene resin, coumarodene resin, petroleum resin, terpene phenol resin; Plasticizers, fillers, antioxidants, etc., such as liquid polybutene, mineral oil, lanolin, liquid polyisoprene, and liquid polyacrylate, can be added. In addition, organic polymer fine particles such as cellulose, polyethylene, polyamide, polypropylene, polyethylene terephthalate, alginic acid, hyaluronic acid, chitin and derivatives thereof and / or zinc oxide, calcium oxide, silica, kaolin, talc, You may mix | blend inorganic substances, such as titanium oxide.

본 발명 제제는 상기한 치료제-함유층(2)을 배제하고 벌레물린 부위 치료제가 함유된 점착제를 지지체에 도포하여 구성시킬 수도 있다.The formulation of the present invention may be constituted by applying the pressure-sensitive adhesive containing the insect bite site treatment to the support by excluding the therapeutic agent-containing layer 2 described above.

이상 설명한 바와 같은 본 발명의 벌레물린 부위 처치용 패취제제는 벌레물린 부위를 외부와 차단하여 긁는 것 등에 의한 환부의 악화를 방지할 수 있고 치료제를 장기간 지속적으로 작용시킬 수 있게 되는 등의 장점이 있는 신규 유용의 발명인 것이다.Patch preparation for insect bite site treatment of the present invention as described above can prevent the deterioration of the affected area by scratching by blocking the insect bite site from the outside, and has the advantage of being able to continuously operate the therapeutic agent for a long time It is a novel useful invention.

Claims (2)

벌레물린 부위 치료제가 함유된 것을 특징으로 하는 벌레물린 부위 처치용 패취제제.Patches for the treatment of insect bites, characterized in that the insect bite site treatment. 제 1 항에 있어서, 지지체(1), 지지체 상의 내측에 위치하여 적층되며 지지체(1) 보다 작은 면적을 갖는 벌레물린 부위 치료제-함유층(2), 상기 치료제-함유층(2) 외부에서 지지체(1)상에 적층되는 점착층(3) 및 이형지(4)가 적층 구성된 것을 특징으로 하는 벌레물린 부위 처치용 패취제제.2. The support (1) according to claim 1, wherein the insect bite site treatment-containing layer (2) having a smaller area than the support (1), stacked on the inside of the support (1), and the support (1) outside the treatment-containing layer (2). Patch agent for insect bite site treatment, characterized in that the adhesive layer (3) and the release paper (4) to be laminated on the laminated structure.
KR1019990038010A 1999-09-08 1999-09-08 Patch preparation for curing a part bitten by insect KR20010026619A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03188149A (en) * 1989-12-15 1991-08-16 Otsuka Pharmaceut Factory Inc High-water content polymer gel
JPH0847507A (en) * 1994-08-08 1996-02-20 Yoshinori Sato Appliance for treating skin bitten by insect
JPH0971539A (en) * 1995-09-08 1997-03-18 Mochida Pharmaceut Co Ltd Antipruritic agent for external use
KR19990026792A (en) * 1997-09-26 1999-04-15 김윤 Matrix Patches Containing Diclofenac Diethylammonium Salt

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03188149A (en) * 1989-12-15 1991-08-16 Otsuka Pharmaceut Factory Inc High-water content polymer gel
JPH0847507A (en) * 1994-08-08 1996-02-20 Yoshinori Sato Appliance for treating skin bitten by insect
JPH0971539A (en) * 1995-09-08 1997-03-18 Mochida Pharmaceut Co Ltd Antipruritic agent for external use
KR19990026792A (en) * 1997-09-26 1999-04-15 김윤 Matrix Patches Containing Diclofenac Diethylammonium Salt

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