KR19980079242A - Skin whitening composition containing sunscreen - Google Patents

Abstract

From about 0.1 to about 30% by weight of an organic sunscreen with chromogenic groups active in the ultraviolet range 290 to 400 nm, an inorganic sunscreen selected from the group consisting of titanium dioxide, zinc oxide and barium sulfate and mixtures thereof Weight percent (organic sunscreen to inorganic sunscreen ratio of 1: 1 to 3: 1), about 0.05 to about 1 weight percent of a co-functional sunscreen selected from the group consisting of ethylene / vinyl acetate copolymers, hydrophobic Acrylate or methacrylate copolymer modified from about 0.1% to about 0.5% by weight, about 0.05% to 0.5% by weight of xanthan gum, about 0.5% to 5% by weight of placental extract, and about 1% to 99.9% by weight of a cosmetically acceptable carrier. Provided is a composition for enhancing skin whitening effect comprising a.

Description

Skin whitening composition containing sunscreen

The present invention relates to cosmetic compositions which are particularly useful for whitening and protecting skin exposed to sunburn, cancer and even photoaging.

Various whitening agents are formulated into cosmetic compositions for removing dark spots and enhancing overall skin whitening. More recently, placental extract has been suggested as a whitening agent. See US Pat. No. 4,696,813, owned by Sansho Seiyiku Company Limited, Japan. The whitening effect of most of these cosmetics is not satisfactory.

An ideal whitening cosmetic composition should combine the whitening enhancement of the whitening agent and the blocking action of the sunscreen active.

Sunscreen compositions are also commonly used to protect skin exposed to burns, cancer and even photoaging. The active agent in the composition acts to block its passage to prevent skin penetration of erythema induced light.

Sunscreen agents can be classified into a group of high color developing monomeric organic compounds, inorganic compounds and extremely color developing polymeric organic solvents in order of decreasing effectiveness. U.S. Pat. No. 5,219,558 (Wooden, Jr.) and U.S. Pat. No. 4,919,934 (Deafner) include octyl methoxycinnamate (Parsol MCX®), benzophenone-3 (oxybenzone), a common sunscreen available commercially. And chromogenic monomeric organic compounds such as octyl dimethyl PABA are disclosed.

A problem associated with such organic compounds is skin irritation. Allergic reactions can occur in people who are sensitive to chromogenic groups of organic molecules. Moreover, due to the activation mechanism, it has been observed that increasing the concentration of organic sunscreen does not necessarily increase the SPF (sun protection factor) and it has also been found that this can actually reduce the protection factor. This side reaction is due in part to the interference of the colloidal particles with sunscreen excess concentrations. Therefore, it is desired to minimize the concentration of such organic compounds. However, since high SPF compositions also require certain types of aesthetics, it is required to replace all of the chromophoric compounds, while in practice it is not feasible.

Inorganic particulate compounds such as titanium dioxide and polyethylene are used as sunscreens. The problem with the use of inorganic compounds is that high SPF values can be obtained only at high concentrations of these materials. Unfortunately, at such high concentrations the aesthetics are impaired and the clear formulation becomes opaque. Excessive application of inorganic particulates can also form noticeable white bubbles on the skin that are perceived negatively by consumers.

Polymeric organic particulates are the last class of these sunscreen materials. US Patent 5008100 (Zecchino) supports oil and water emulsions containing polyethylene particles of overactive sunscreens in addition to traditional chromogenic organic compounds. Similar to inorganic materials, polymer particles are limited in their sunscreen effectiveness. Large amounts of such materials will have an adverse effect on the aesthetics of the formulation.

It is therefore an object of the present invention to provide a whitening composition that acts as a sunscreen agent while minimizing the concentration of chromogenic monomeric organic compounds and also maximizing sun protection factors.

Another object of the present invention is to provide a whitening composition in the form of an oil or water emulsion which exhibits an enhanced aesthetic when applied to the skin.

It is another object of the present invention to provide a whitening composition which enhances the whitening effect on the skin while providing sun protection with a much lower irritation rate for humans than a composition of the same SPF.

These and other objects according to the present invention will be more readily understood from the following description and examples.

According to the invention,

a) about 0.1 to about 30 weight percent of an organic sunscreen agent having a color developing active in the ultraviolet region of 290 to 400 nm;

b) about 0.1 to about 10 weight percent of an inorganic sunscreen agent selected from the group consisting of titanium dioxide, zinc oxide and barium sulfate (the ratio of organic sunscreen agents to inorganic sunscreen agents is 1: 1 to 3: 1);

c) about 0.05 to about 1 weight percent of a co-functional sunscreen selected from the group consisting of ethylene vinyl acetate copolymers;

d) hydrophobically modified acrylates formed from about 50 to about 99 weight percent of monoolefinically unsaturated carboxylic acid or anhydride monomers having 3 to 6 carbon atoms and from about 1 to about 50 weight percent of long chain acrylate or methacrylate ester monomers, or Methacrylate copolymer about 0.1 to about 0.5 weight percent;

e) about 0.05 to 0.5 weight percent of xanthan rubber;

f) about 0.1 to 5 weight percent of placental extract;

g) A composition for enhancing whitening effect is provided, comprising about 1 to 99.9% by weight of an acceptable carrier in a cosmetic.

The present inventors have found that the rheologically ideal blend of hydrophobically modified acrylate or methacrylate polymers and xanthan gum, and combinations of ethylene copolymer compounds with sunscreen protection of certain chromogenic organic sunscreen compounds in combination with certain inorganic sunscreen compounds It was unexpectedly found to increase factor (SPF). Due to the increase in SPF from the copolymer mixture, the concentration of chromogenic organic compounds can be minimized to avoid skin irritation, and the concentration of inorganic compounds can be reduced to enhance the aesthetics of the product.

In a preferred embodiment the composition appears to have an SPF of at least 15, preferably 15 to 25, with substantially no irritation to the user.

Thus the most important element of the composition is the component of the hydrophobically modified acrylate or methacrylate polymer. Preferably the polymer is formed from about 50 to 99% by weight of a mono olefinically unsaturated carboxylic acid or anhydride monomer having 3 to 6 carbon atoms and about 1 to 50% by weight of a long chain C ₁₀ -C ₃₀ acrylate or methacrylate ester monomer. Copolymer. In some cases, a crosslinkable monomer may be included in the monomer mixture. In a preferred embodiment the amount of acrylate monomer is 20 to 1% by weight, in particular 10 to 2% by weight, based on the weight of the two monomers, while the amount of carboxylic acid monomer is 80 to 99% by weight, in particular 90 to 98% by weight. The amount of carboxylic acid monomer and acrylate ester monomer is based on the combined weight of the two components. It should be understood that one or more carboxylic acid monomers and one or more acrylate esters may be used to form the copolymer.

Preferred acrylic ester monomers having long chain aliphatic groups are derivatives of acrylic acid represented by the formula below.

Wherein R ¹ is selected from hydrogen, methyl and ethyl groups and R ² is an alkyl group having 10 to 30 carbon atoms, and a group selected from oxyalkylene and carbonyloxyalkylene groups, preferably an alkyl group having 10 to 22 carbon atoms. Oxyalkylene and carbonyloxyalkylene groups are in particular oxyethylene and carbonyloxyethylene groups. Representative higher alkyl acrylate esters are decyl acrylate, lauryl acrylate, stearyl acrylate, behenyl acrylate and myristyl acrylate, and corresponding methacrylates.

The structure and synthesis of hydrophobically modified acrylate or methacrylate polymers are described in US Pat. No. 3,915,921 (Schlatzer, jr.), US Pat. No. 4,062,817 (Westerman), US Pat. No. 4,509,949, incorporated herein by reference. Huang et al.).

For the purposes of the present invention, hydrophobically modified copolymers can be neutralized with a base to convert free carboxylic acid groups suspended from the copolymer into their relatively neutralized salts. Suitable neutralizing agents are alkali metal bases such as sodium hydroxide, potassium hydroxide and lithium hydroxide. Organic amine type bases may also be used, most preferably triethanolamine.

Hydrophobically modified copolymers such as those described above are available from Carbopol 1328®. F. BF Goodrich Company is commercially available. The INCI name is an acrylate / C ₁₀ -C ₃₀ alkyl acrylate cross polymer.

The amount of hydrophobically modified acrylate or methacrylate polymer is in the range of about 0.005 to about 1 weight percent, preferably about 0.01 to about 0.5 weight percent, more preferably about 0.1 to about 0.2 weight percent.

The second critical element of the composition is the presence of xanthan gum in an amount comparable to the amount of acrylate / methacrylate polymer. The amount of xanthan rubber is limited by the 'rubbery' unpleasant feel that enters the emulsion while rubbing. Xanthan rubber is incorporated in the range of about 0.005 to about 1% by weight, preferably about 0.01 to about 0.5% by weight, more preferably about 0.1 to about 2% by weight.

The third critical element of the composition is a co-functional sunscreen such as an ethylene vinyl copolymer compound. The amount of this material is in the range of about 0.10 to about 5.00 weight percent, preferably about 0.5 to about 3.00 weight percent, optimally about 1 to about 2.00 weight percent. Preferred compounds are supplied by Allied Signal as AC-400 copolymers.

Preferably the sunscreen co-functional and hydrophobically modified acrylate or methacrylate polymers are present in a ratio of 1: 1 to about 1: 6.

The organic sunscreen agent of the present invention has at least one color generator which absorbs in the ultraviolet range of approximately 290-400 nm. Chromic organic sunscreen agents can be divided into the following areas (specific examples), including:

p-aminobenzoic acid, salts thereof and derivatives thereof (ethyl, isobutyl, glyceryl esters; p-dimethylaminobenzoic acid); Anthranilate (o-aminobenzoate; methyl, menthyl, phenyl, benzyl, phenylethyl, linalyl, terpinyl, and cyclohexenyl ester); Salicylates (octyl, amyl, phenyl, benzyl, menthyl, glyceryl, and dipropylene glycol esters); Cinnamic acid derivatives (methyl and benzyl esters, α-phenyl cinnamonitrile; butyl cinnamoyl pyruvate); Dihydroxycinnamic acid derivatives (umbelliferone, methylumbelliferone, methylaceto-umbelliferone); Trihydroxycinnamic acid derivatives (esculletin, methylesculletin, daphnetine, and glucosides, esculin and daphnin); Hydrocarbons (diphenylbutadiene, stilbene); Dibenzalacetone and benzalacetophenone; Naphtholsulfonate (sodium salt of 2-naphthol-3,6-disulfonic acid and 2-naphthol-6,8-disulfonic acid); Dihydroxy-naphthoic acid and salts thereof; o- and p-hydroxybiphenyldisulfonate; Coumarin derivatives (7-hydroxy, 7-methyl, 3-phenyl); Diazoles (2-acetyl-3-bromoindazole, phenyl benzoxazole, methyl naphthazole, various aryl benzothiazoles); Quinine salts (bissulphates, sulfates, chlorides, oleates, and tannates); Quinoline derivatives (8-hydroxyquinoline salt, 2-phenylquinoline); Hydroxy- or methoxy-substituted benzophenones; Urinary acid or bilauric acid; Tannic acid or derivatives thereof (eg, hexaethyl ether); (Butyl carbityl) (6-propyl pyreronyl) ether; Hydroquinone; Benzophenone (oxybenzone, sulfisobenzone, dioxybenzone, benzoresorcinol, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dime Oxybenzophenone, octabenzone; 4-isopropyldibenzoylmethane; butylmethoxydibenzoylmethane; etocrylene; and 4-isopropyl-dibenzoylmethane).

Particularly useful are 2-ethylhexyl p-methoxycinnamate, 4,4'-t-butyl methoxydibenzoylmethane, 2-hydroxy-4-methoxybenzophenone, octyldimethyl p-aminobenzoic acid, digaloyl tree Oleate, 2,2-dihydroxy-4-methoxybenzophenone, ethyl 4- [bis (hydroxypropyl)] aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylic Latex, 2-ethylhexyl salicylate, glyceryl p-aminobenzoate, 3,3,5-trimethylcyclohexyl salicylate, methyl anthranilate, p-dimethylaminobenzoic acid or aminobenzoate, 2-ethylhexyl p-dimethylaminobenzoate, 2-phenylbenzimidazole-5-sulfonic acid, 2- (p-dimethylaminophenyl) -5-sulfoniobenzoxazophosphate or mixtures thereof.

Suitable commercially available organic sunscreens are those defined in the table below.

TABLE 1

CTFA Name product name producer Benzophenone-3 UVINUL M-40 BASF Chemical Co. Benzophenone-4 UVINUL MS-40 BASF Chemical Co. Benzophenone-8 SPECTRA-SORB UV-24 American cyanamid DEA-methoxycinnamate BERNEL HYDRO Bernel Chemical Ethyl dihydroxypropyl-PABA AMERSCREEN P Amerchol Corp. Glyceryl PABA NIPA G.M.P.A. Nipa Labs. Homosalate KEMESTER HMS Humko chemical Menthyl anthranilate SUNAROME UVA Felton worldwide Octocrylene UVINUL N-539 BASF Chemical Co. Octyl dimethyl PABA AMERSCOL Amerchol Corp. Octyl methoxycinnamate PARSOL MCX Bernel Chemical Octyl salicylate SUNAROME WMO Felton worldwide PABA PABA National starch 2-phenylbenzimidazole-5-sulfonic acid EUSOLEX 232 EM Industries TEA Salicylate SUNAROME W Felton worldwide 2- (4-methylbenzylidene) -camphor EUSOLEX 6300 EM Industries Benzophenone-1 UVINUL 400 BASF Chemical Co. Benzophenone-2 UVINUL D-50 BASF Chemical Co. Benzophenone-6 UVINUL D-49 BASF Chemical Co. Benzophenone-12 UVINUL 408 BASF Chemical Co. 4-isopropyl dibenzoyl methane EUSOLEX 8020 EM Industries Butyl Methoxy Dibenzoyl Methane PARSOL 1789 Givaudan roure Etocrylene UVINUL N-35 BASF Chemical Co.

The amount of sunscreen mentioned above is generally in the range of about 0.1 to about 30% by weight, preferably about 2 to about 20% by weight, optimally about 3 to about 8% by weight.

Inorganic sunscreen compounds useful in the present invention are titanium dioxide, zinc oxide, barium sulfate and mixtures thereof. The amount of material should be present in the range of about 0.50 to about 5 weight percent, preferably about 1 to about 4 weight percent, optimally 2 to about 3.5 weight percent.

The weight ratio of the chromogenic monomeric organic compound to the relative to the inorganic particulate compound is in the range of about 4: 1 to 1: 1, optimally about 3: 1 to 1: 1.

Whitening agents useful for enhancing the skin whitening effect can be obtained from placental extracts. Placenta extract can be processed by any method conventionally used in the art, such as the method described in US Pat. No. 4,696,813. Placental extracts are also marketed as Placendol (registered trademark) supplied by Pentapharm / Centerchem and Bio-Bpl supplied by Ikeda Corp. Placental extract should be present in the composition in an amount of about 0.5 to about 10 weight percent, preferably 1 to about 5 weight percent, optimally about 2 to about 5 weight percent.

The composition of the present invention may comprise an aqueous phase or may be entirely aqueous. Advantageous pHs of such aqueous systems range from about 8.0 to 4.5.

The composition of the present invention may also include a water soluble vitamin that can act as an electrolyte. The term water soluble is defined as a material having a solubility in water of at least 0.1% by weight, preferably at least 0.5% by weight and optimally at least 5% by weight. Examples of water soluble vitamins are niakin, vitamin B ₂ , vitamin B ₆ , vitamin C and biotin. One source of vitamin C is a commercial product of Vitamin C (registered trademark), available from Brooks Company. Niacin, vitamin B and biotin can be purchased from Roche Pharmaceuticals. The total amount of vitamin in the composition according to the invention may range from about 0.001 to about 1% by weight, preferably from about 0.01 to about 0.6% by weight, optimally from about 0.1 to about 0.5% by weight.

Two classes of epithelial solubilizers can also be effectively used in the compositions of the present invention. The first class is represented by C ₇ -C ₃₀ β-hydroxy carboxylic acids and salts and esters thereof. Examples of this class are salicylic acid and alkali metals and ammonium salts thereof. Suitable amounts of salicylic acid or salt may range from about 0.001 to about 10 weight percent, preferably from about 0.8 to about 2.5 weight percent, optimally from about 1 to 1.5 weight percent.

The second class of epithelial solubilizers is C ₂ -C ₂₅ α-hydroxy alkanoic acid. Examples of substances in this group are glycolic acid, lactic acid, α-hydroxyoctanoic acid and salts and esters thereof. The salt may be selected from alkali metals, ammonium and C ₁ -C ₂₀ alkyl or alkanolammonium ammonium. The concentration of α-hydroxyalkanoic acid may range from about 0.001 to about 10 weight percent, preferably about 0.2 to 1 weight percent, optimally about 0.4 to 0.5 weight percent.

The composition of the present invention may be aqueous or anhydrous. Preferably the composition is an aqueous, in particular water and oil emulsion, in the form of W / O or O / W. For water, the amount may range from about 5 to about 90 weight percent, preferably from about 35 to about 65 weight percent, optimally from about 40 to 55 weight percent.

In addition to water, relatively volatile solvents may also be incorporated into the compositions of the present invention. Most preferred are monovalent C ₁ -C ₃ alkanols. This includes ethyl alcohol, methyl alcohol isopropyl alcohol. The amount of monovalent alkanol may range from about 5 to about 50 weight percent, preferably from about 15 to about 40 weight percent, optimally from about 25 to about 35 weight percent.

Softening materials in the form of silicone oils and synthetic esters may be incorporated into the compositions of the present invention. The amount of softener can be in any range between about 0.1 to about 30 weight percent, preferably about 1 to 20 weight percent.

Silicone oils can be divided into volatile and nonvolatile types. The term 'volatile' as used herein refers to a substance having a vapor pressure that can be measured at ambient temperature. Preferred volatile silicone oils are selected from cyclic or linear polydimethylsiloxanes containing about 3 to about 9, preferably about 4 to about 5 silicon atoms.

Linear volatile silicone materials generally have a viscosity of less than about 5 centistokes at 25 ° C., while cyclic materials typically have a viscosity of less than about 10 centistokes.

Nonvolatile silicone oils useful as softening materials include polyalkyl siloxanes, polyalkylaryl siloxanes, and polyether siloxane copolymers. For example, basically nonvolatile polyalkyl siloxanes useful in the present invention include polydimethyl siloxanes having a viscosity of about 5 to about 100,000 centistokes at 25 ° C. Among the preferred nonvolatile softeners useful in the present compositions are polydimethyl siloxanes having a viscosity of about 10 to about 400 centistokes at 25 ° C.

Among the ester softeners include the following.

(1) Alkenyl or alkyl esters of branched or straight chain fatty acids having 9 to 22 carbon atoms. Examples of them are isononyl isonanonoate, oleyl myristate, oleyl stearate, and especially oleyl oleate among them.

(2) ether-esters, such as fatty acid esters of ethoxylated fatty alcohols.

(3) polyhydric alcohol esters. Ethylene glycol mono- and di-fatty acid esters, diethylene glycol mono- and di-fatty acid esters, polyethylene glycol (200-6000) mono- and di-fatty acid esters, propylene glycol mono- and di-fatty acid esters, polypropylene glycol 2000 Monooleate, polypropylene glycol 2000 monostearate, ethoxylated propylene glycol monostearate, glyceryl mono- and di-fatty acid esters, polyglycerol polyfatty esters, ethoxylated glyceryl monostearate, 1,3-butylene Glycol monostearate, 1,3-butylene glycol distearate, polyoxyethylene polyol fatty acid esters, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters and pentaerythritol fatty acid esters are satisfactory polyhydric alcohol esters.

(4) wax esters such as biswax, spermaceti, myristyl myristate, stearyl stearate.

(5) sterol esters, examples of which are cholesterol fatty acid esters.

Most preferred esters are octyldodecyl neopentanoate (Elefac I-205: commercially available) and isononyl isononanoate.

Fatty acids having 10 to 30 carbon atoms may also be included in the compositions of the present invention. Examples of this class include pelagonate, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, hydroxystearic acid, oleic acid, linoleic acid, ricinoleic acid, arachidic acid, behenic acid and erucine It is a mountain.

Wetting agents of the polyhydric alcohol type may also be included in the compositions of the present invention. Wetting agents help increase the efficiency of emollients, reduce scale formation, promote removal of the formed scale, and improve skin feel. Typical polyhydric alcohols include alkylene polyols and derivatives thereof, including glycerol, polyalkylene glycols and more preferably propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, hexylene Glycols, 1,3-butylene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, glycerol homopolymers, propoxylated glycerol and mixtures thereof. For best results, wetting agent is preferably 1,3 butylene glycol. The amount of wetting agent may range from 0.5 to 30% by weight, preferably 1 to 15% by weight of the composition.

Collectively, water, solvents, silicones, esters, fatty acids, humectants and / or thickeners are considered as acceptable carriers for cosmetics for the compositions of the present invention. The total amount of carrier is in the range of about 1 to 99.9% by weight, preferably 80 to 99% by weight.

The cosmetic composition of the present invention may be in any form. These forms include lotions, creams, rolled formulations, mousse, aerosol sprays and pad formulations.

Surface active agents may also be present in the cosmetic compositions of the present invention. The total concentration of the surface active agent is in the range of about 0.1 to about 40 weight percent, preferably about 1 to about 20 weight percent, optimally about 1 to about 5 weight percent of the total composition. The surface active agent can be selected from the group consisting of anionic, nonionic, cationic and amphoteric actives. Particularly preferred nonionic surface active agents include C ₁₀ -C ₂₀ fatty alcohols or acid hydrophobic materials condensed with from about 2 to about 100 moles of ethylene oxide or propylene oxide per mole of hydrophobic material; C ₂ -C ₁₀ alkyl phenols condensed with 2 to 20 moles of alkylene oxide; Mono- or di-fatty acid esters of ethylene glycol; Fatty acid monoglycerides; Sorbitan, mono- and di-C ₈ -C ₂₀ fatty acids; And polyoxyethylene sorbitan and combinations thereof. Alkyl polyglycosides and saccharide fatty amides (eg methyl gluconamide) are also suitable nonionic surface active agents.

Preferred anionic surface active agents include soaps, alkyl ether sulfates and sulfonates, alkyl sulfates and sulfonates, alkylbenzene sulfonates, alkyl and dialkyl sulfosuccinates, C ₈ -C ₂₀ acyl isethionates, C _8- C ₂₀ alkyl ether phosphates and combinations thereof.

Preservatives may preferably be incorporated into the cosmetic compositions of the present invention to defend against the growth of potentially harmful microorganisms. Traditional preservatives suitable for the compositions of the present invention are alkyl esters of para-hydroxybenzoic acid. Other preservatives that have been used more recently are hydantoin derivatives, propionate salts, and various quaternary ammonium compounds. Cosmetic chemists are well aware of appropriate preservatives and routinely select those that satisfy anti-preservation tests and give stability to the product. Particularly preferred preservatives are phenoxyethanol, methyl paraben, propyl paraben, imidazolidinyl urea, sodium dehydroacetate and benzyl alcohol. Preservatives should be selected with consideration of the use of the composition and possible incompatibilities between the preservatives and other components in the emulsion. Preservatives are preferably used in amounts ranging from about 0.01% to about 2% by weight of the composition.

In addition, minor accessory ingredients may be present in the cosmetic composition. Among them are water insoluble vitamins such as vitamin A palmitate, vitamin E acetate and DL-panthenol.

Other accessory ingredients may include enzymes. Especially preferred are superoxide dismutases, available as Biocell SODs from the Brooks Company, USA.

Natural vegetable materials from renewable resources are often required in cosmetic compositions. For example, the cosmetic composition of the present invention may comprise o-derived β-glucan, available as Microat SF® from Nurture Inc., Misora, Montana, USA. .

Colorants, fragrances, opaques, and abrasives may also be included in the compositions of the present invention. These materials may each range from about 0.05 to about 5 weight percent, preferably 0.1 to 3 weight percent.

The following examples will more fully illustrate aspects of the present invention. All parts, percentages, and ratios cited in this specification and the appended claims are by weight unless otherwise indicated.

Example 1

Whitening lotions, typically fully formulated according to the present invention, have been prepared as conventionally known and described below.

ingredient % W / W Deionized water 51.8 glycerin 3.0 Butylene Glycol 0.9 Disodium EDTA 0.1 Methylparaben 0.3 Xanthan rubber 0.1 Carbopol 1382: registered trademark (2%) 7.5 Tioveil AQ (N): registered trademark 2.4 Polymethyl methacrylate 1.0 Isononyl isononanoate 2.3 Pentaerythritol tetraoctanoate 1.0 Isostearic acid 1.2 Elefac I-205: registered trademark 3.8 Steares-21 1.2 Steares-2 0.3 Cetyl alcohol 1.0 Arlacel 165 VS (GMS / PEG): registered trademark 1.7 Trilaures-4 Phosphate 0.20 Propylparaben 0.2 Ethylene / Vinyl Acetate Copolymer 0.2 Xalifin 15: registered trademark 0.2 Parsol MCX: registered trademark 5.0 Dow Corning 344: registered trademark 5.5 Gransil PM 56: registered trademark 1.0 Vitamin E Acetate 0.1 Triethanolamine 0.5 Phenoxyethanol 0.7 Placenta extract 3.0 Sodium hyaluronate 0.95 Seamollient: registered trademark 0.25 DL-panthenol 0.3

The foregoing description and examples illustrate selected aspects of the invention. In their case, various modifications may be made to those skilled in the art within the spirit and scope of the present invention.

Example 2

Samples of the compositions according to Example 1 were prepared incorporating Carbopol 1328 (Carbopol 1382®) (2%) at 0.05% and 0.15% by weight to give an SPF of 16.

Each sample was stored in an oven at 43 ° C. at 25 ° C., 43 ° C. and alternating temperature 4 ° C. The stability of the sample determined by Brookfield Viscosity Spindle # 3 at 25 ° C. and 20 rpm was visually observed. These measurements were performed for at least six weeks.

The sample phase containing only 0.05% by weight of Carbopol 1328® (2%) phase was separated before 2 weeks and titanium dioxide precipitated out of the system.

Samples of the present invention were free of diluent, phase separation and agglomeration of titanium dioxide for at least 6 weeks in SPF 16.

Sample 2A Sample 2B ingredient % W / W % W / W Deionized water 51.8 56.8 glycerin 3.0 3.0 Butylene Glycol 0.9 0.9 Disodium EDTA 0.1 0.1 Methylparaben 0.3 0.3 Xanthan rubber 0.1 0.1 Carbopol 1382: registered trademark (2%) 7.5 2.5 Tioveil AQ (N): registered trademark 2.4 2.4 Polymethyl methacrylate 1.0 1.0 Isononyl isononanoate 2.3 2.3 Pentaerythritol tetraoctanoate 1.0 1.0 Isostearic acid 1.2 1.2 Elefac I-205: registered trademark 3.8 3.8 Steares-21 1.2 1.2 Steares-2 0.3 0.3 Cetyl alcohol 1.0 1.0 Arlacel 165 VS (GMS / PEG): registered trademark 1.7 1.7 Trilaures-4 Phosphate 0.2 0.2 Propylparaben 0.2 0.2 Ethylene / Vinyl Acetate Copolymer 0.2 0.2 Xalifin 15: registered trademark 0.2 0.2 Parsol MCX: registered trademark 5.0 5.0 Dow Corning 344: registered trademark 5.5 5.5 Gransil PM 56: registered trademark 1.0 1.0 Vitamin E Acetate 0.1 0.1 Triethanolamine 0.5 0.5 Phenoxyethanol 0.7 0.7 Placenta extract 3.0 3.0 Sodium hyaluronate 0.95 0.95 Seamollient: registered trademark 0.25 0.25 DL-panthenol 0.3 0.3

Measurement of SPF was performed using an SPF 290 analyzer from Optoometrics Corporation, Ayer, Massachusetts.

The SPF 290 analyzer enables in vitro SPF measurements of sunscreen products. The data generated was found to provide a ranking method that would aid in the development and optimization of sunscreen formulations.

The optical scanning system of the SPF 290 consists of a xenon light source, an integrated collection port, a color correction filter, a diffusion grating, a monochromator, and a detector coupled to a computer.

During the test, the light emitted by the xenon bulb is collected in the integrated sphere via the product and the substrate. The light now passes through a monochromatic system optimized for efficiency in the ultraviolet region. Light rays exiting the monochromatic system collide with the photosensitive surface and produce a signal that is proportional to the density of the light hitting the surface. Blank pieces of substrate are used as reference. The SPF 290 analyzer records 23 data points as the monochromator moves from 290 nm to 400 nm at intervals of 5 nm. As a result of the measurements made on the substrate as well as the substrate with the sample product, Monochromatic Protection Factor (MPF) is developed. MPF is therefore defined as the ratio of the signal of the sample-free original reference substrate to the sample plus the substrate for a particular wavelength.

Samples 3A to 3G include active sunscreen ingredients (Parsol MCX®, Tioveil AQ-N®), rheology modifiers (Xanthan Rubber and Carbopol 1328®) and structure formers ethylene / vinyl acetate copolymers (AC 400: trademark copolymer).

3A 3B 3C 3D 3E 3F 3G ingredient % W / W Deionized water Quantity Quantity Quantity Quantity Quantity Quantity Quantity glycerin 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Butylene Glycol 0.9 0.9 0.9 0.9 0.9 0.9 0.9 Disodium EDTA 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Methylparaben 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Xanthan rubber 0.09 0.09 0.09 0.09 - - - Carbopol 1382: registered trademark (2%) 6.2 6.2 6.2 6.2 6.2 - - Tioveil AQ (N): registered trademark 2.4 2.4 - 2.4 2.4 2.4 2.4 Polymethyl methacrylate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Isononyl isononanoate 2.25 2.25 2.25 2.25 2.25 2.25 2.25 Pentaerythritol tetraoctanoate 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Isostearic acid 1.2 1.2 1.2 1.2 1.2 1.2 1.2 Elefac I-205: registered trademark 3.8 3.8 3.8 3.8 3.8 3.8 3.8 Steares-21 1.2 1.2 1.2 1.2 1.2 1.2 1.2 Steares-2 0.3 0.3 0.3 0.3 0.3 0.3 0.3 Cetyl alcohol 0.6 0.6 0.6 0.6 0.6 0.6 0.6 Behenyl alcohol 0.4 0.4 0.4 0.4 0.4 0.4 0.4 Arlacel 165 VS (GMS / PEG): registered trademark 1.7 1.7 1.7 1.7 1.7 1.7 1.7 Trilaures-4 Phosphate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Propylparaben 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Ethylene / Vinyl Acetate Copolymer 0.2 0.2 0.2 - 0.2 - 0.2 Xalifin 15: registered trademark 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Parsol MCX: registered trademark 5.0 - 5.0 5.0 5.0 5.0 5.0 Dow Corning 344: registered trademark 5.5 5.5 5.5 5.5 5.5 5.5 5.5 Gransil PM 56: registered trademark 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Vitamin E Acetate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Triethanolamine 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Phenoxyethanol 0.7 0.7 0.7 0.7 0.7 0.7 0.7 Placenta extract 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Sodium hyaluronate 0.9 0.9 0.9 0.9 0.9 0.9 0.9 Seamollient: registered trademark 0.25 0.25 0.25 0.25 0.25 0.25 0.25 DL-panthenol 0.3 0.3 0.3 0.3 0.3 0.3 0.3 air freshener 0.06 0.06 0.06 0.06 0.06 0.06 0.06

The corresponding in vitro SPF values for the samples are shown in the chart below.

3A 3B 3C 3D 3E 3F 3G SPF 21.5 4.7 11.7 16.1 16.2 11.8 15.4

From the above SPF results, the active sunscreen component (Parsol MCX®, Tioveil AQ (N): trademark), rheology modifier (Xanthan Rubber, Carbopol 1328: trademark) and structure former (ethylene / vinyl acetate aerial) It can be seen that a significantly higher SPF (Sample 3A) can be obtained when the copolymer-AC 400 copolymer (registered trademark) is used in the same formulation.

In practical conditions such a combination will allow to obtain a prototype of a particular SPF value using a very significantly low concentration of potentially irritating organic sunscreen.

While the whitening composition of the present invention acts as a sunscreen agent to maximize sun protection factor, the content of chromogenic monomeric organic compounds is minimized, so that the stimulation rate of the human body is much lower than that of the same sun protection factor, and the sense of beauty is excellent.

Claims (5)

a) about 0.1 to about 30 weight percent of an organic sunscreen agent having a color developing active in the ultraviolet region of 290 to 400 nm; b) about 0.1 to about 10 weight percent of an inorganic sunscreen agent selected from the group consisting of titanium dioxide, zinc oxide, barium sulfate and mixtures thereof (the ratio of organic sunscreen agent to inorganic sunscreen agent is 1: 1 to 3: 1) ); c) about 0.05 to about 1 weight percent of a co-functional sunscreen selected from the group consisting of ethylene / vinyl acetate copolymers; d) hydrophobically modified acrylates formed from about 50 to about 99 weight percent of monoolefinically unsaturated carboxylic acid or anhydride monomers having 3 to 6 carbon atoms and from about 1 to about 50 weight percent of long chain acrylate or methacrylate ester monomers, or Methacrylate copolymer about 0.1 to about 0.5 weight percent; e) about 0.05 to 0.5 weight percent of xanthan rubber; f) about 0.5 to 5 weight percent of placental extract; g) A cosmetic composition for enhancing skin whitening effect, comprising about 1 to 99.9% by weight of an acceptable carrier for cosmetics. The composition of claim 1 wherein the SPF is at least 15. The method of claim 1 wherein the organic sunscreen agent is benzophenone-3, benzophenone-4, benzophenone-6, benzophenone-8, benzophenone-12, butyl methoxy dibenzoyl methane, PABA, octyl dimethyl PABA, octyl meth A composition selected from the group consisting of oxycinnamate and combinations thereof. The composition of claim 1, further comprising about 0.5 to about 5.0 weight percent of a water insoluble vitamin. To substantially enhance the skin whitening effect a) about 0.1 to about 30 weight percent of an organic sunscreen agent having a color developing active in the ultraviolet region of 290 to 400 nm; b) about 0.1 to about 10 weight percent of an inorganic sunscreen agent selected from the group consisting of titanium dioxide, zinc oxide, barium sulfate and mixtures thereof (the ratio of organic sunscreen agent to inorganic sunscreen agent is 1: 1 to 3: 1) ); c) about 0.05 to about 1 weight percent of a co-functional sunscreen selected from the group consisting of ethylene / vinyl acetate copolymers; d) hydrophobically modified acrylates formed from about 50 to about 99 weight percent of monoolefinically unsaturated carboxylic acid or anhydride monomers having 3 to 6 carbon atoms and from about 1 to about 50 weight percent of long chain acrylate or methacrylate ester monomers, or Methacrylate copolymer about 0.1 to about 0.5 weight percent; e) about 0.05 to 0.5 weight percent of xanthan rubber; f) about 0.5 to 5 weight percent of placental extract; g) a method of enhancing the skin whitening effect comprising applying a cosmetic composition comprising about 1 to 99.9% by weight of an acceptable carrier in a cosmetic.