KR19980011008U - Multiple blood bags to remove white blood cell layer - Google Patents
Multiple blood bags to remove white blood cell layer Download PDFInfo
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- KR19980011008U KR19980011008U KR2019960024491U KR19960024491U KR19980011008U KR 19980011008 U KR19980011008 U KR 19980011008U KR 2019960024491 U KR2019960024491 U KR 2019960024491U KR 19960024491 U KR19960024491 U KR 19960024491U KR 19980011008 U KR19980011008 U KR 19980011008U
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- soft layer
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- 239000008280 blood Substances 0.000 title claims abstract description 48
- 210000004369 blood Anatomy 0.000 title claims abstract description 43
- 210000000265 leukocyte Anatomy 0.000 title claims abstract description 29
- 238000010241 blood sampling Methods 0.000 claims 1
- 210000001772 blood platelet Anatomy 0.000 abstract description 14
- 239000000306 component Substances 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 9
- 239000012503 blood component Substances 0.000 abstract description 6
- 239000012141 concentrate Substances 0.000 abstract description 5
- 239000003634 thrombocyte concentrate Substances 0.000 abstract description 4
- 238000005119 centrifugation Methods 0.000 abstract description 3
- 230000002950 deficient Effects 0.000 abstract description 3
- 210000002381 plasma Anatomy 0.000 description 9
- 210000003743 erythrocyte Anatomy 0.000 description 8
- 238000010586 diagram Methods 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 3
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 208000003441 Transfusion reaction Diseases 0.000 description 2
- 230000000735 allogeneic effect Effects 0.000 description 2
- 210000000601 blood cell Anatomy 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/14—Devices for taking samples of blood ; Measuring characteristics of blood in vivo, e.g. gas concentration within the blood, pH-value of blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/04—Constructional details of apparatus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0439—White blood cells; Leucocytes
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
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Abstract
혈액을 채혈한 후 원심분리를 통하여 혈액성분을 제제할 때, 다층의 혈액성분중 수혈 부작용 요소의 하나인 백혈구 연층(Buffy Coat ; 연막)을 정확히 제거할 수 있게한 백혈구 연층을 제거하기 위한 다중 혈액백에 관한 것으로,When blood components are prepared by centrifugation after collecting blood, multiple blood to remove leukocyte soft layer that can accurately remove white blood cell (Buffy Coat), one of the side effects of transfusion among multiple blood components On the bag,
본 고안은, 채혈백에 채혈된 혈액을 원심분리시켜 혈소판이 포함된 혈장성분을 제1자백으로 수용되게 함과 아울러 백혈구 연층을 제3자백에 수용되게 하여 상기 채혈백에는 백혈구 연층이 제거된 적혈구 농축액이 잔류되고, 이어서 제1자백에 수용된 혈소판을 포함한 혈장성분을 원심분리시켜 제2자백에 혈소판이 결핍된 혈장을 수용되게 하되 상기 제1자백에는 혈소판 농축액만이 잔류되게 함에 따라, 발열성 수혈 부작용의 주요 원인인 백혈구 연층을 제거하게 된 것이다.The present invention, by centrifuging the blood collected in the blood collection bag to receive the plasma component containing platelets as the first confession, and the leukocyte soft layer to be accommodated in the third confession, the leukocyte soft layer was removed in the blood collection bag The concentrate remains, followed by centrifugation of plasma components including platelets contained in the first confetti to accommodate the platelet deficient plasma in the second confession, but only the platelet concentrate remains in the first confession, thereby exothermic transfusion The main cause of the side effect is to remove the white blood cell layer.
Description
본 고안은 백혈구 연층을 제거하기 위한 다중 혈액백, 더욱 상세하게는 혈액을 채혈한 후 원심분리를 통하여 혈액성분을 제제할 때 다층의 혈액성분중 수혈 부작용 요소의 하나인 백혈구 연층(Buffy Coat ; 연막)을 정확히 제거할 수 있게한 백혈구 연층을 제거하기 위한 다중 혈액백에 관한 것이다.The present invention is a multi-blood bag for removing leukocyte soft layer, more specifically, leukocyte soft layer (Buffy Coat), which is one of the side effects of transfusion among multiple blood components when blood components are prepared by centrifugation after collecting blood. The present invention relates to a multiple blood bag for removing leukocyte soft layer that can be removed accurately).
일반적으로, 전혈 또는 적혈구 농축액 속에는 백혈구, 혈소판 그리고 혈장 단백질이 포함되어 있다.Generally, whole blood or erythrocyte concentrates contain white blood cells, platelets, and plasma proteins.
수혈을 자주 받는 환자나 경산부는 백혈구 항원 및 혈장단백질에 의한 동종 면역의 발생 가능성이 높은 것으로 알려져 있으며, 상기 동종면역은 알레르기성, 발열성 수혈 반응 또는 혈소판 수혈의 불능화를 초래 하는 문제점이 있었다.Patients who frequently receive blood transfusions or women with a high blood transfusion are known to have high potential for allogeneic immunity due to leukocyte antigens and plasma proteins, and allogeneic immunity has been associated with allergic, febrile transfusion reactions or disabling platelet transfusion.
위와 같은 발열성 수혈의 부작용은 백혈구 응집소가 주요 원인인 것으로 알려져 있으며, 이러한 이유로 인하여 중증, 재발성, 발열성 및 비용혈성 수혈반응을 일으켰던 환자에게는 반드시 백혈구 연층을 제거한 적혈구 제제를 수혈해야 되었다.The side effects of fever transfusion are known to be the main cause of leukocyte agglutination. For this reason, patients with severe, recurrent, fever and non-hemostatic transfusion reactions should be transfused with red blood cell depleted leukocytes.
우리나라에는 아직까지 백혈구 연층을 제거한 적혈구의 성상에 관한 기준이 없었으나, 미국에서는 혈액은행 협회(America Association of Blood Banks) 등의 기구를 통하여 원래 적혈구의 80% 이상을 회수하되 백혈구수를 5×108개 이하가 되도록 정하고 있다.In Korea, there are no standards on the appearance of erythrocytes from which the white blood cell layer has been removed.However, in the United States, more than 80% of the original red blood cells are recovered through a mechanism such as the American Association of Blood Banks. It is decided to be eight or less.
한편, 도 1 은 채혈된 혈액을 원심분리하여 그 성분을 층별로 나타낸 것으로서, 하단의 1번 층은 혈구성분이고, 2번 층은 백혈구 연층이며, 3번 층은 혈소판 포함 혈장성분으로 분리된다.On the other hand, Figure 1 shows the components of each layer by centrifuging the blood collected, the lower layer of the first layer is the blood cell component, the second layer is the leukocyte soft layer, and the third layer is separated into platelet-containing plasma components.
도 2 는 상기 작용에 의해 분리된 혈액을 분리 수용하게된 종래의 혈액백의 일예를 나타낸 것이다.Figure 2 shows an example of a conventional blood bag to separate and receive the blood separated by the above action.
즉, 채혈침기(4)로 부터 튜브(5)를 통하여 채혈백(6)이 연결되고, 이 채혈백(6)에는 보조튜브(5')를 통하여 제1자백(7)과 제2자백(8)이 순차적으로 연결되어 있다.That is, the blood collection bag 6 is connected to the blood collection bag 4 through the tube 5, and the blood collection bag 6 is connected to the first confession 7 and the second confession through the auxiliary tube 5 '. 8) are sequentially connected.
상기 채혈백(6)에는 백혈구 연층이 포함된 적혈구 농축액이 수용되고, 제1자백(7)에는 혈소판 농축액이, 그리고 제2자백(8)에는 혈소판 결핍 혈장이 수용되어 있으므로, 백혈구 연층을 전혀 제거 할 수 없는 문제점이 있었다.The red blood cell concentrate containing the white blood cell layer is accommodated in the blood collection bag 6, the platelet concentrate is contained in the first sack 7, and the platelet deficient plasma is contained in the second sack 8, thereby eliminating the leukocyte soft layer at all. There was a problem that could not be done.
본 고안은 위와 같은 종래의 채혈백의 문제점을 감안하여 안출한 것으로서, 그 목적은 수혈시 발생되는 부작용들중 적어도 백혈구 응집소로 인한 부작용을 방지할 수 있는 백혈구 연층을 제거하기 위한 혈액백을 제공하는 것이다.The present invention has been made in view of the problems of the conventional blood collection bag as described above, the object is to provide a blood bag for removing the leukocyte soft layer that can prevent the side effects caused by at least leukocyte aggregates among the side effects that occur during blood transfusion .
이러한 목적을 달성하기 위한 본 고안은, 채혈백에 채혈된 혈액을 원심분리시켜 혈소판이 포함된 혈장성분을 제1자백으로 수용되게 함과 아울러 백혈구 연층을 제3자백에 수용되게 하여 상기 채혈백에는 백혈구 연층이 제거된 적혈구 농축액이 잔류되고, 이어서 제1자백에 수용된 혈소판을 포함한 혈장성분을 원심분리시켜 제2자백에 혈소판이 결핍된 혈장을 수용되게 하되 상기 제1자백에는 혈소판 농축액만이 잔류되게 함에 따라, 발열성 수혈 부작용의 주요 원인인 백혈구 연층을 제거함을 특징으로 한다.The present invention for achieving the above object, by centrifuging the blood collected in the blood collection bag to receive the plasma components containing platelets as the first confession and the leukocyte soft layer is accommodated in the third confession The red blood cell concentrate from which the leukocyte soft layer was removed remains, and then the plasma components including the platelets contained in the first confetti are centrifuged to accommodate the platelet-deficient plasma in the second confetti, but only the platelet concentrate remains in the first confetti. As a result, it is characterized in that the removal of the leukocyte soft layer, which is the main cause of the side effects of fever transfusion.
도 1 은 일반적인 혈액성분을 층별로 나타낸 구성도,1 is a block diagram showing the general blood components by layer,
도 2 는 종래의 3중 혈액백을 나타낸 구성도,2 is a block diagram showing a conventional triple blood bag,
도 3 은 본 고안의 실시예의 다중 혈액백을 나타낸 구성도,3 is a block diagram showing a multi-blood bag of an embodiment of the present invention,
도 4 (a),(b)는 본 고안의 다중 혈액백의 사용상태 예시도이다.Figure 4 (a), (b) is an illustration of the state of use of multiple blood bags of the present invention.
*도면의 주요부분에 대한 부호의 설명** Description of the symbols for the main parts of the drawings *
1 : 혈구성분2 : 백혈구 연층1: blood cell component 2: white blood cell soft layer
3 : 혈소판 포함 혈장성분10 : 혈액백3: platelet-containing plasma component 10: blood bag
11 : 튜브12 : 채혈침기11: tube 12: blood collection
13 : 보조튜브14, 15 : 제1·제2분기튜브13: auxiliary tube 14, 15: first and second branch tube
20, 30, 40 : 제1·제2·제3자백20, 30, 40: 1st, 2nd, 3rd confession
이하, 본 고안의 백혈구 연층을 제거하기 위한 다중 혈액백을 첨부도면을 참조하여 설명하면 다음과 같다.Hereinafter, with reference to the accompanying drawings, a multi-blood bag for removing the leukocyte soft layer of the present invention is as follows.
도 3 은 본 고안의 실시예의 다중 혈액백을 나타낸 구성도로서, 혈액백(10)의 일측에 혈액을 채혈하기 위한 채혈침기(12)와 튜브(11)가 연결되어 있고, 상기 혈액백(10)의 타측에 보조튜브(13)가 연결되어 이에 제1분기튜브(14)와 제2분기튜브(15)가 연결되어 있다.3 is a block diagram showing a multi-blood bag according to an embodiment of the present invention, the blood collection device 12 for collecting blood on one side of the blood bag 10 and the tube 11 is connected, the blood bag 10 Auxiliary tube 13 is connected to the other side of the) is connected to the first branch tube 14 and the second branch tube (15).
상기 제1분기튜브(14)의 단부에는 제1자백(20)과 제3자백(40)이 분할되게 연결되고, 상기 제2분기튜브(15)에는 제2자백(30)이 연결되어 있다.An end of the first branch tube 14 is divided into a first sack 20 and a third sack 40, and a second sack 30 is connected to the second branch tube 15.
도 4 는 본 고안의 다중 혈액백의 사용상태를 나타낸 것으로, 먼저 혈액이 채혈된 혈액백(10)을 원심분리 시키면, 제1도에서와 같이 혈액성분이 3층으로 분리된다.Figure 4 shows the state of use of the multi-blood bag of the present invention, when the blood bag 10, the blood is collected first, centrifuged, blood components are separated into three layers as shown in FIG.
이때, 혈소판이 포함된 혈장성분을 제1자백(20)으로 옮기되, 백혈구 연층을 제3자백(40)으로 옮기면 상기 채혈백(10)에는 백혈구 연층이 제거된 적혈구 농축액이 잔류된다(도 4(a)참조).At this time, the plasma components containing platelets are transferred to the first confession 20, and the leukocyte soft layer is transferred to the third confession 40, and the red blood cell concentrate from which the leukocyte soft layer is removed remains in the blood collection bag 10 (FIG. 4). (a) See).
이어서, 상기 제1자백(20)에 수용된 혈소판이 포함된 혈장성분을 원심분리 시키면, 상기 제1자백(20)에는 혈소판 농축액의 남게되는 반면 제2자백(30)으로 부터는 혈소판이 결핍된 혈장을 얻을 수 있게 된다(도 4(b)참조).Subsequently, when the plasma component containing platelets contained in the first confession 20 is centrifuged, the platelet concentrate remains in the first confession 20 while the platelets lack plasma from the second confession 30. It can obtain (refer FIG. 4 (b)).
한편, 혈액백(10)으로 부터 제1∼제3자백(20)(30)(40)으로 혈액을 옮길때 튜브(11)와 보조튜브(13) 및 제1·제2분기튜브(14)(15)를 선택적으로 개폐시켜 층별로 분리하게 된다.On the other hand, when the blood is transferred from the blood bag 10 to the first to third porcelains 20, 30 and 40, the tube 11, the auxiliary tube 13 and the first and second branch tubes 14 15 is selectively opened and closed to separate the layers.
따라서 상기와 같은 본 고안은 수혈시 발생되는 각종 부작용들 중 그 주요 원인으로 지적되는 백혈구 연층을 간단한 방법으로 제거하여 적혈구 제제를 공급하게 된다.Therefore, the present invention as described above provides a red blood cell preparation by removing the leukocyte soft layer, which is pointed out as the main cause of various side effects generated during blood transfusion, by a simple method.
이와 같은 본 고안은 백혈구 연층을 효율적으로 제거하여 수혈로 인한 위험성과 부작용을 방지하고, 의료사고의 발생빈도를 현저히 줄이게 됨과 아울러 제작이 간편한 유용한 고안이다.The present invention is to effectively remove the leukocyte soft layer to prevent risks and side effects due to blood transfusions, significantly reduce the frequency of medical accidents and is a useful design is easy to manufacture.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR2019960024491U KR19980011008U (en) | 1996-08-16 | 1996-08-16 | Multiple blood bags to remove white blood cell layer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR2019960024491U KR19980011008U (en) | 1996-08-16 | 1996-08-16 | Multiple blood bags to remove white blood cell layer |
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| KR19980011008U true KR19980011008U (en) | 1998-05-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| KR2019960024491U KR19980011008U (en) | 1996-08-16 | 1996-08-16 | Multiple blood bags to remove white blood cell layer |
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| KR (1) | KR19980011008U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030085257A (en) * | 2002-04-29 | 2003-11-05 | 주식회사 셀론텍 | A blood bag and method for separating cell using of it |
-
1996
- 1996-08-16 KR KR2019960024491U patent/KR19980011008U/en not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030085257A (en) * | 2002-04-29 | 2003-11-05 | 주식회사 셀론텍 | A blood bag and method for separating cell using of it |
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